PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33156617-2 2020 In humans and other eukaryotic organisms, the arsenite methyltransferase (AS3MT) protein methylates arsenite. arsenite 46-54 arsenite methyltransferase Homo sapiens 74-79 24361376-1 2014 Arsenic(III)methyltransferase (AS3MT) has been demonstrated to be the key enzyme in the metabolism of arsenic as it catalyses the methylation of arsenite and monomethylarsonic acid (MMA) to form methylated arsenic species, which have higher toxic and genotoxic potential than the parent compounds. arsenite 145-153 arsenite methyltransferase Homo sapiens 31-36 29217265-5 2018 The methylation of arsenite by arsenite-3-methyltransferase (As3MT) promotes the clearance of arsenic as pentavalent species, but also generates reactive trivalent intermediates. arsenite 19-27 arsenite methyltransferase Homo sapiens 31-59 29217265-5 2018 The methylation of arsenite by arsenite-3-methyltransferase (As3MT) promotes the clearance of arsenic as pentavalent species, but also generates reactive trivalent intermediates. arsenite 19-27 arsenite methyltransferase Homo sapiens 61-66 29398653-7 2018 Genotyping for the main arsenite and selenium methyltransferases, AS3MT and INMT, was performed using TaqMan probes or Sequenom. arsenite 24-32 arsenite methyltransferase Homo sapiens 66-71 25286945-3 2014 Arsenic(III) S-adenosylmethionine methyltransferases (AS3MT in animals and ArsM in microbes) are key enzymes of arsenic biotransformation, catalyzing the methylation of inorganic arsenite to give methyl, dimethyl and trimethyl products. arsenite 179-187 arsenite methyltransferase Homo sapiens 54-59 22955273-0 2012 Rapid equilibrium kinetic analysis of arsenite methylation catalyzed by recombinant human arsenic (+3 oxidation state) methyltransferase (hAS3MT). arsenite 38-46 arsenite methyltransferase Homo sapiens 90-136 22955273-0 2012 Rapid equilibrium kinetic analysis of arsenite methylation catalyzed by recombinant human arsenic (+3 oxidation state) methyltransferase (hAS3MT). arsenite 38-46 arsenite methyltransferase Homo sapiens 138-144 21537954-11 2011 These findings indicated that AS3MT expression enhanced the cytotoxic effect of arsenite in tet(+) cells because these cells accumulated more arsenic metabolites than did the tet(-) cells, and accordingly, the tet(+) cells were more susceptible to arsenic than were the tet(-) cells. arsenite 80-88 arsenite methyltransferase Homo sapiens 30-35 20621156-0 2010 New insights into the mechanism of arsenite methylation with the recombinant human arsenic (+3) methyltransferase (hAS3MT). arsenite 35-43 arsenite methyltransferase Homo sapiens 115-121 21266075-5 2011 The model simulates uptake of arsenite (iAsIII) via aquaporin isozymes 9 (AQP9s), glutathione (GSH) conjugation, methylation by arsenic methyltransferase (AS3MT), efflux through multidrug resistant proteins (MRPs) and the induced antioxidant response via thioredoxin reductase (TR) activity. arsenite 30-38 arsenite methyltransferase Homo sapiens 155-160 20571777-1 2011 Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite. arsenite 101-109 arsenite methyltransferase Homo sapiens 6-52 20571777-1 2011 Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite. arsenite 101-109 arsenite methyltransferase Homo sapiens 54-59 20621156-7 2010 Initial velocity studies illuminate an ordered sequence for the binding of SAM and arsenite to the hAS3MT; while GSH should probably be placed either as the first reactant or as a reactant combining with the enzyme only after products have been released. arsenite 83-91 arsenite methyltransferase Homo sapiens 99-105 19411561-0 2009 Expression of AS3MT alters transcriptional profiles in human urothelial cells exposed to arsenite. arsenite 89-97 arsenite methyltransferase Homo sapiens 14-19 20129672-0 2010 Transition metal ions and selenite modulate the methylation of arsenite by the recombinant human arsenic (+3 oxidation state) methyltransferase (hAS3MT). arsenite 63-71 arsenite methyltransferase Homo sapiens 97-143 20129672-0 2010 Transition metal ions and selenite modulate the methylation of arsenite by the recombinant human arsenic (+3 oxidation state) methyltransferase (hAS3MT). arsenite 63-71 arsenite methyltransferase Homo sapiens 145-151 20129672-1 2010 This report demonstrates that transition metal ions and selenite affect the arsenite methylation by the recombinant human arsenic (+3 oxidation state) methyltransferase (hAS3MT) in vitro. arsenite 76-84 arsenite methyltransferase Homo sapiens 122-168 20129672-1 2010 This report demonstrates that transition metal ions and selenite affect the arsenite methylation by the recombinant human arsenic (+3 oxidation state) methyltransferase (hAS3MT) in vitro. arsenite 76-84 arsenite methyltransferase Homo sapiens 170-176 20129672-2 2010 Co(2+), Mn(2+), and Zn(2+) inhibited the arsenite methylation by hAS3MT in a concentration-dependent manner and the kinetics indicated Co(2+) and Mn(2+) to be mixed (competitive and non-competitive) inhibitors while Zn(2+) to be a competitive inhibitor. arsenite 41-49 arsenite methyltransferase Homo sapiens 65-71 19932709-1 2010 Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite. arsenite 101-109 arsenite methyltransferase Homo sapiens 6-52 19932709-1 2010 Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite. arsenite 101-109 arsenite methyltransferase Homo sapiens 54-59 18334919-2 2008 It has recently been shown that arsenic(III)methyltransferase (AS3MT) enzyme catalyses the methylation of arsenite and monomethylarsonous acid (MMA). arsenite 106-114 arsenite methyltransferase Homo sapiens 63-68 18976679-1 2009 Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite, and intronic single-nucleotide polymorphisms (SNPs: G7395A, G12390C, T14215C, T35587C, and G35991A) in the AS3MT gene were shown to be related to inter-individual variation in the arsenic metabolism. arsenite 101-109 arsenite methyltransferase Homo sapiens 6-52 18976679-1 2009 Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite, and intronic single-nucleotide polymorphisms (SNPs: G7395A, G12390C, T14215C, T35587C, and G35991A) in the AS3MT gene were shown to be related to inter-individual variation in the arsenic metabolism. arsenite 101-109 arsenite methyltransferase Homo sapiens 54-59 16102566-6 2005 Here, we characterize the metabolism and cytotoxicity of arsenite (iAs(III)) and methylated trivalent arsenicals in parental cells and clonal cells expressing AS3MT. arsenite 57-65 arsenite methyltransferase Homo sapiens 159-164 17889916-2 2007 Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite. arsenite 101-109 arsenite methyltransferase Homo sapiens 6-52 17889916-2 2007 Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite. arsenite 101-109 arsenite methyltransferase Homo sapiens 54-59 15526190-0 2005 A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19. arsenite 27-35 arsenite methyltransferase Homo sapiens 100-123