PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32765280-0 2020 JNK and Autophagy Independently Contributed to Cytotoxicity of Arsenite combined With Tetrandrine via Modulating Cell Cycle Progression in Human Breast Cancer Cells. arsenite 63-71 mitogen-activated protein kinase 8 Homo sapiens 0-3 24184208-3 2014 However, quantitative image analysis of JNK1 localization following exposure of cells to either arsenite or hyperosmotic stress did not indicate its nuclear accumulation. arsenite 96-104 mitogen-activated protein kinase 8 Homo sapiens 40-44 30713663-15 2019 Both rapamycin treatment and mTOR knockdown enhanced ERK activity further, but reduced JNK activity and the p62 level in arsenite-treated cells. arsenite 121-129 mitogen-activated protein kinase 8 Homo sapiens 87-90 26291278-6 2015 Conversely, arsenite-induced H3S10 phosphorylation and HO-1 expression were blocked by N-acetylcysteine (NAC), the c-Jun N-terminal kinase (JNK) inhibitor SP600125, and JNK knockdown (siJNK). arsenite 12-20 mitogen-activated protein kinase 8 Homo sapiens 115-138 26291278-6 2015 Conversely, arsenite-induced H3S10 phosphorylation and HO-1 expression were blocked by N-acetylcysteine (NAC), the c-Jun N-terminal kinase (JNK) inhibitor SP600125, and JNK knockdown (siJNK). arsenite 12-20 mitogen-activated protein kinase 8 Homo sapiens 140-143 26291278-6 2015 Conversely, arsenite-induced H3S10 phosphorylation and HO-1 expression were blocked by N-acetylcysteine (NAC), the c-Jun N-terminal kinase (JNK) inhibitor SP600125, and JNK knockdown (siJNK). arsenite 12-20 mitogen-activated protein kinase 8 Homo sapiens 169-172 25237887-0 2014 Arsenite-activated JNK signaling enhances CPEB4-Vinexin interaction to facilitate stress granule assembly and cell survival. arsenite 0-8 mitogen-activated protein kinase 8 Homo sapiens 19-22 24184208-7 2014 In contrast, arsenite exposure which did not alter the initial rates of nuclear accumulation of GFP, GFP-T-antigen or GFP-JNK1, decreased the t1/2 for nuclear accumulation of both GFP and GFP-JNK1. arsenite 13-21 mitogen-activated protein kinase 8 Homo sapiens 192-196 23715767-6 2013 The expression of Egr-1, p21 and JNK was strongly increased after treatment of the cells with TPA, tumor necrosis factor-alpha (TNF-alpha) or arsenite. arsenite 142-150 mitogen-activated protein kinase 8 Homo sapiens 33-36 23968725-5 2013 Blockage of the ERK1/2, p38 and JNK down-regulated the VEGF level, while ERK1/2 and p38 inhibitors were more effective than JNK in attenuating arsenite-induced COX-2 expression. arsenite 143-151 mitogen-activated protein kinase 8 Homo sapiens 32-35 23968725-5 2013 Blockage of the ERK1/2, p38 and JNK down-regulated the VEGF level, while ERK1/2 and p38 inhibitors were more effective than JNK in attenuating arsenite-induced COX-2 expression. arsenite 143-151 mitogen-activated protein kinase 8 Homo sapiens 124-127 23376440-8 2013 Induction of Cox-2 mRNA levels by arsenite was attenuated by inhibitors of ERK, p38 and JNK. arsenite 34-42 mitogen-activated protein kinase 8 Homo sapiens 88-91 23219847-7 2013 Beside caspase-9 and caspase-3 inhibitors, suppression of JNK activity decreased levels of arsenite-induced apoptosis in NSC. arsenite 91-99 mitogen-activated protein kinase 8 Homo sapiens 58-61 23469214-9 2013 CONCLUSION: The results indicate that miR-21 is both a target and a regulator of ERK/NF-kappaB and JNK/c-Jun and the feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1, respectively, are involved in arsenite-induced malignant transformation of HELF cells. arsenite 209-217 mitogen-activated protein kinase 8 Homo sapiens 99-102 23194660-0 2013 The accumulations of HIF-1alpha and HIF-2alpha by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells. arsenite 126-134 mitogen-activated protein kinase 8 Homo sapiens 50-53 23194660-6 2013 In contrast, a high level of arsenite activates c-Jun N-terminal kinases (JNK), which provoke a response to suppress ubiquitinated HIF-1alpha degradation. arsenite 29-37 mitogen-activated protein kinase 8 Homo sapiens 48-72 23194660-6 2013 In contrast, a high level of arsenite activates c-Jun N-terminal kinases (JNK), which provoke a response to suppress ubiquitinated HIF-1alpha degradation. arsenite 29-37 mitogen-activated protein kinase 8 Homo sapiens 74-77 23194660-7 2013 Down-regulation of HIF-1alpha by inhibiting JNK, however, increases the DNA damage but decreases the apoptosis induced by a high level of arsenite. arsenite 138-146 mitogen-activated protein kinase 8 Homo sapiens 44-47 23194660-8 2013 Thus, data in the present study suggest that the accumulations of HIF-1alpha and HIF-2alpha by JNK and ERK are involved in different levels of arsenite-induced biphasic effects, with low levels of arsenite inducing cell proliferation and high levels of arsenite inducing DNA damage and apoptosis in HBE cells. arsenite 143-151 mitogen-activated protein kinase 8 Homo sapiens 95-98 23194660-8 2013 Thus, data in the present study suggest that the accumulations of HIF-1alpha and HIF-2alpha by JNK and ERK are involved in different levels of arsenite-induced biphasic effects, with low levels of arsenite inducing cell proliferation and high levels of arsenite inducing DNA damage and apoptosis in HBE cells. arsenite 197-205 mitogen-activated protein kinase 8 Homo sapiens 95-98 23194660-8 2013 Thus, data in the present study suggest that the accumulations of HIF-1alpha and HIF-2alpha by JNK and ERK are involved in different levels of arsenite-induced biphasic effects, with low levels of arsenite inducing cell proliferation and high levels of arsenite inducing DNA damage and apoptosis in HBE cells. arsenite 197-205 mitogen-activated protein kinase 8 Homo sapiens 95-98 23469214-7 2013 Down-regulation of miR-21 and up-regulations of Pdcd44 or Spry1 blocked the arsenite-induced activations of JNK/c-Jun or ERK/NF-kappaB, indicating that knockdown of miR-21 inhibits feedback of ERK activation and JNK activation via increases of Pdcd4 and Spry1 protein levels, respectively. arsenite 76-84 mitogen-activated protein kinase 8 Homo sapiens 108-111 23469214-7 2013 Down-regulation of miR-21 and up-regulations of Pdcd44 or Spry1 blocked the arsenite-induced activations of JNK/c-Jun or ERK/NF-kappaB, indicating that knockdown of miR-21 inhibits feedback of ERK activation and JNK activation via increases of Pdcd4 and Spry1 protein levels, respectively. arsenite 76-84 mitogen-activated protein kinase 8 Homo sapiens 212-215 19910486-9 2010 In addition, cell treatment with arsenite results in recruitment of WDR62 to SG and activated JNK to processing bodies (PB). arsenite 33-41 mitogen-activated protein kinase 8 Homo sapiens 94-97 22100391-0 2012 Phosphorylation of the M3/6 dual-specificity phosphatase enhances the activation of JNK by arsenite. arsenite 91-99 mitogen-activated protein kinase 8 Homo sapiens 84-87 22100391-4 2012 It has been shown that M3/6 itself is phosphorylated by JNK upon stimulation with arsenite, but the role of this phosphorylation has not been investigated. arsenite 82-90 mitogen-activated protein kinase 8 Homo sapiens 56-59 22100391-9 2012 Interestingly, expression of M3/6 phosphorylation mutants delayed the time-course of JNK phosphorylation and activation by arsenite. arsenite 123-131 mitogen-activated protein kinase 8 Homo sapiens 85-88 22366412-4 2012 Here, we find that, in human embryo lung fibroblast (HELF) cells, arsenite induces the activation of dependent protein kinase catalytic subunit (DNA-PKcs), which then phosphorylates and activates c-Jun N-terminal kinases 2 (JNK2), but not JNK1. arsenite 66-74 mitogen-activated protein kinase 8 Homo sapiens 239-243 21726611-0 2011 Up-regulation of cyclin D1 by JNK1/c-Jun is involved in tumorigenesis of human embryo lung fibroblast cells induced by a low concentration of arsenite. arsenite 142-150 mitogen-activated protein kinase 8 Homo sapiens 30-34 21726611-6 2011 Moreover, arsenite activates the JNK1/c-Jun signal pathway, but not JNK2, which up-regulates the expression of cyclin D1/CDK4 and phosphorylates the retinoblastoma (Rb) protein. arsenite 10-18 mitogen-activated protein kinase 8 Homo sapiens 33-37 21726611-7 2011 Blocking of the JNK1/c-Jun signal pathway suppresses the increases of cyclin D1 expression and Rb phosphorylation, which attenuates cell proliferation, reduces the transition from the G1 to the S phase, and thereby inhibits the neoplastic transformation of HELF cells induced by a low concentration of arsenite. arsenite 302-310 mitogen-activated protein kinase 8 Homo sapiens 16-20 21726611-8 2011 Thus, activation of the JNK1/c-Jun pathway up-regulates the expression of cyclin D1, which is involved in the tumorigenesis caused by a low concentration of arsenite. arsenite 157-165 mitogen-activated protein kinase 8 Homo sapiens 24-28 19808956-10 2009 Our results show that Tpl2 plays a key role in arsenite-induced COX-2 expression and PGE(2) production and further elucidate the role of Tpl2 in arsenite signals that activate ERK/JNK and NF-kappaB/AP-1 in JB6 P+ cells. arsenite 47-55 mitogen-activated protein kinase 8 Homo sapiens 180-183 19808956-7 2009 We also found that arsenite-induced phosphorylation of extracellular signal-regulated kinases (ERK) or c-Jun NH(2)-terminal kinases (JNK) was markedly suppressed by Tpl2 kinase inhibitor or Tpl2 short hairpin RNA. arsenite 19-27 mitogen-activated protein kinase 8 Homo sapiens 103-131 19808956-7 2009 We also found that arsenite-induced phosphorylation of extracellular signal-regulated kinases (ERK) or c-Jun NH(2)-terminal kinases (JNK) was markedly suppressed by Tpl2 kinase inhibitor or Tpl2 short hairpin RNA. arsenite 19-27 mitogen-activated protein kinase 8 Homo sapiens 133-136 19808956-8 2009 Inhibition of arsenite-induced ERK or JNK signaling using a pharmacologic inhibitor of ERK or JNK substantially blocked COX-2 expression. arsenite 14-22 mitogen-activated protein kinase 8 Homo sapiens 38-41 19808956-8 2009 Inhibition of arsenite-induced ERK or JNK signaling using a pharmacologic inhibitor of ERK or JNK substantially blocked COX-2 expression. arsenite 14-22 mitogen-activated protein kinase 8 Homo sapiens 94-97 19808956-10 2009 Our results show that Tpl2 plays a key role in arsenite-induced COX-2 expression and PGE(2) production and further elucidate the role of Tpl2 in arsenite signals that activate ERK/JNK and NF-kappaB/AP-1 in JB6 P+ cells. arsenite 145-153 mitogen-activated protein kinase 8 Homo sapiens 180-183 19519318-0 2009 PI3K/Akt/JNK/c-Jun signaling pathway is a mediator for arsenite-induced cyclin D1 expression and cell growth in human bronchial epithelial cells. arsenite 55-63 mitogen-activated protein kinase 8 Homo sapiens 9-12 19519318-7 2009 Overall, our data suggest a pathway of PI-3K/Akt/JNK/c-Jun/cylin D1 signaling in response to arsenite in human bronchial epithelial cells. arsenite 93-101 mitogen-activated protein kinase 8 Homo sapiens 49-52 17289100-0 2007 Biphasic effect of arsenite on cell proliferation and apoptosis is associated with the activation of JNK and ERK1/2 in human embryo lung fibroblast cells. arsenite 19-27 mitogen-activated protein kinase 8 Homo sapiens 101-104 18201741-2 2008 The goal of the present study was to determine the role of JNK pathway signaling for regulating B-cell apoptosis in two important but contrasting situations--global proteotoxic damage, induced by arsenite and hyperthermia, versus specific microtubule inhibition, induced by the anti-cancer drug vincristine, using the EW36 B-cell line. arsenite 196-204 mitogen-activated protein kinase 8 Homo sapiens 59-62 18201741-4 2008 Exposure of EW36 B-cells to arsenite or lethal hyperthermia resulted in activation of the JNK pathway and induction of apoptosis. arsenite 28-36 mitogen-activated protein kinase 8 Homo sapiens 90-93 17289100-3 2007 In the present study, we aimed at investigating the relationship between biphasic effect of arsenite on cell proliferation and apoptosis and activation of JNK and ERK1/2 in human embryo lung fibroblast (HELF) cells. arsenite 92-100 mitogen-activated protein kinase 8 Homo sapiens 155-158 17289100-6 2007 During stimulation phospho-JNK levels were significantly increased at 3, 6, and 12 h after 0.1 or 0.5 microM arsenite exposure. arsenite 109-117 mitogen-activated protein kinase 8 Homo sapiens 27-30 17289100-7 2007 Phospho-ERK1/2 levels were increased with different concentrations (0.1-10 microM) of arsenite at 6, 12, and 24 h. Blocking of JNK pathway with 20 microM SP600125 or ERK1/2 by 100 microM PD98059 significantly inhibited biphasic effect of arsenite in cells. arsenite 86-94 mitogen-activated protein kinase 8 Homo sapiens 127-130 17289100-7 2007 Phospho-ERK1/2 levels were increased with different concentrations (0.1-10 microM) of arsenite at 6, 12, and 24 h. Blocking of JNK pathway with 20 microM SP600125 or ERK1/2 by 100 microM PD98059 significantly inhibited biphasic effect of arsenite in cells. arsenite 238-246 mitogen-activated protein kinase 8 Homo sapiens 127-130 17289100-8 2007 Data in the present study suggest that activation of JNK and ERK1/2 may be involved in biphasic effect of arsenite when measuring cell proliferation and apoptosis in HELF cells. arsenite 106-114 mitogen-activated protein kinase 8 Homo sapiens 53-56 15734884-7 2005 Arsenite-induced activation of JNK and p38 MAPK was distinct, with only JNK as a downstream target of the EGF receptor. arsenite 0-8 mitogen-activated protein kinase 8 Homo sapiens 31-34 17116751-0 2006 IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response. arsenite 105-113 mitogen-activated protein kinase 8 Homo sapiens 49-52 17116751-3 2006 We provide a novel scenario of the proapoptotic role of IkappaB kinase beta (IKKbeta)-NF-kappaB, which can act as the activator of the JNK pathway through the induction of GADD45alpha for triggering MKK4/JNK activation, in response to the stimulation of arsenite, a cancer therapeutic reagent. arsenite 254-262 mitogen-activated protein kinase 8 Homo sapiens 135-138 17116751-3 2006 We provide a novel scenario of the proapoptotic role of IkappaB kinase beta (IKKbeta)-NF-kappaB, which can act as the activator of the JNK pathway through the induction of GADD45alpha for triggering MKK4/JNK activation, in response to the stimulation of arsenite, a cancer therapeutic reagent. arsenite 254-262 mitogen-activated protein kinase 8 Homo sapiens 204-207 15734884-0 2005 EGF receptor-dependent JNK activation is involved in arsenite-induced p21Cip1/Waf1 upregulation and endothelial apoptosis. arsenite 53-61 mitogen-activated protein kinase 8 Homo sapiens 23-26 14514659-6 2004 In contrast, a high level (40 micro M) of arsenite stimulated the c-Jun N-terminal kinase (JNK) signaling pathway and induced cell apoptosis, and this arsenite-induced JNK activity was blocked by JNK inhibitor II, SP600125. arsenite 42-50 mitogen-activated protein kinase 8 Homo sapiens 66-89 14967008-8 2004 Moreover, exposure of PAECs to NAC alleviated the arsenite-induced JNK/AP-1 activation and apoptosis, whereas exposure of PAECs to BSO enhanced the arsenite-induced JNK/AP-1 activation and apoptosis. arsenite 50-58 mitogen-activated protein kinase 8 Homo sapiens 67-70 14967008-8 2004 Moreover, exposure of PAECs to NAC alleviated the arsenite-induced JNK/AP-1 activation and apoptosis, whereas exposure of PAECs to BSO enhanced the arsenite-induced JNK/AP-1 activation and apoptosis. arsenite 148-156 mitogen-activated protein kinase 8 Homo sapiens 165-168 15028728-6 2004 On the other hand, signaling pathways including those of phosphatidylinositol 3-kinase-AKT, MEK-ERK, and JNK play a protective role against arsenite-induced oxidative stress and apoptosis in melanoma cells. arsenite 140-148 mitogen-activated protein kinase 8 Homo sapiens 105-108 14514659-6 2004 In contrast, a high level (40 micro M) of arsenite stimulated the c-Jun N-terminal kinase (JNK) signaling pathway and induced cell apoptosis, and this arsenite-induced JNK activity was blocked by JNK inhibitor II, SP600125. arsenite 42-50 mitogen-activated protein kinase 8 Homo sapiens 91-94 14514659-6 2004 In contrast, a high level (40 micro M) of arsenite stimulated the c-Jun N-terminal kinase (JNK) signaling pathway and induced cell apoptosis, and this arsenite-induced JNK activity was blocked by JNK inhibitor II, SP600125. arsenite 42-50 mitogen-activated protein kinase 8 Homo sapiens 168-171 14514659-6 2004 In contrast, a high level (40 micro M) of arsenite stimulated the c-Jun N-terminal kinase (JNK) signaling pathway and induced cell apoptosis, and this arsenite-induced JNK activity was blocked by JNK inhibitor II, SP600125. arsenite 42-50 mitogen-activated protein kinase 8 Homo sapiens 168-171 14514659-6 2004 In contrast, a high level (40 micro M) of arsenite stimulated the c-Jun N-terminal kinase (JNK) signaling pathway and induced cell apoptosis, and this arsenite-induced JNK activity was blocked by JNK inhibitor II, SP600125. arsenite 151-159 mitogen-activated protein kinase 8 Homo sapiens 66-89 14514659-6 2004 In contrast, a high level (40 micro M) of arsenite stimulated the c-Jun N-terminal kinase (JNK) signaling pathway and induced cell apoptosis, and this arsenite-induced JNK activity was blocked by JNK inhibitor II, SP600125. arsenite 151-159 mitogen-activated protein kinase 8 Homo sapiens 91-94 14514659-6 2004 In contrast, a high level (40 micro M) of arsenite stimulated the c-Jun N-terminal kinase (JNK) signaling pathway and induced cell apoptosis, and this arsenite-induced JNK activity was blocked by JNK inhibitor II, SP600125. arsenite 151-159 mitogen-activated protein kinase 8 Homo sapiens 168-171 14514659-6 2004 In contrast, a high level (40 micro M) of arsenite stimulated the c-Jun N-terminal kinase (JNK) signaling pathway and induced cell apoptosis, and this arsenite-induced JNK activity was blocked by JNK inhibitor II, SP600125. arsenite 151-159 mitogen-activated protein kinase 8 Homo sapiens 168-171 12426127-8 2002 In contrast, overexpression of dominant-negative JNK1 increased cell transformation even though it inhibited arsenite-induced JNK activation. arsenite 109-117 mitogen-activated protein kinase 8 Homo sapiens 49-53 12946653-8 2003 Blockade of NF-kappaB or JNK activity further enhanced arsenite-induced apoptosis. arsenite 55-63 mitogen-activated protein kinase 8 Homo sapiens 25-28 12426127-8 2002 In contrast, overexpression of dominant-negative JNK1 increased cell transformation even though it inhibited arsenite-induced JNK activation. arsenite 109-117 mitogen-activated protein kinase 8 Homo sapiens 49-52 11948422-4 2002 Both anisomycin and arsenite activate the JNK pathway and, in addition, inactivate the M3/6 phosphatase. arsenite 20-28 mitogen-activated protein kinase 8 Homo sapiens 42-45 12075113-10 2002 Significantly, the sensitization of resistant cells is characterized by a lowering of the threshold concentration of arsenite required to activate the JNK pathway and induce apoptosis. arsenite 117-125 mitogen-activated protein kinase 8 Homo sapiens 151-154 11983707-6 2002 The essential role of the p38 and JNK stress pathways in up-regulation of VDR expression is further confirmed by using the chemical stimulator arsenite. arsenite 143-151 mitogen-activated protein kinase 8 Homo sapiens 34-37 12075113-0 2002 Differential activation of the c-Jun N-terminal kinase pathway in arsenite-induced apoptosis and sensitization of chemically resistant compared to susceptible B-lymphoma cell lines. arsenite 66-74 mitogen-activated protein kinase 8 Homo sapiens 31-54 11429707-0 2001 Contrasting roles of NF-kappaB and JNK in arsenite-induced p53-independent expression of GADD45alpha. arsenite 42-50 mitogen-activated protein kinase 8 Homo sapiens 35-38 11429707-2 2001 We report here that arsenite induces GADD45alpha expression in a p53-independent fashion and that this GADD45alpha induction by arsenite is regulated by NF-kappaB and c-Jun-N-terminal kinase (JNK) oppositely. arsenite 128-136 mitogen-activated protein kinase 8 Homo sapiens 192-195 11429707-5 2001 Expression of a dominant-negative mutant of SEK1 that blocks JNK activation decreased arsenite-induced GADD45alpha expression. arsenite 86-94 mitogen-activated protein kinase 8 Homo sapiens 61-64 11055208-13 2000 The signal cascade triggered by arsenite-like heat stress induces the activity of the mitogen-activated protein (MAP) kinases, extracellular regulated kinase (ERK), c-jun terminal kinase (JNK), and p38. arsenite 32-40 mitogen-activated protein kinase 8 Homo sapiens 165-186 11055208-13 2000 The signal cascade triggered by arsenite-like heat stress induces the activity of the mitogen-activated protein (MAP) kinases, extracellular regulated kinase (ERK), c-jun terminal kinase (JNK), and p38. arsenite 32-40 mitogen-activated protein kinase 8 Homo sapiens 188-191 11055208-14 2000 Through the JNK and p38 pathways, arsenite activates the immediate early genes c-fos, c-jun, and egr-1, usually activated by various growth factors, cytokines, differentiation signals, and DNA-damaging agents. arsenite 34-42 mitogen-activated protein kinase 8 Homo sapiens 12-15 10618720-4 1999 Both arsenate and arsenite activation of JNK requires Rac and Rho. arsenite 18-26 mitogen-activated protein kinase 8 Homo sapiens 41-44 10964950-9 2000 Expression of dominant-interfering mutants of the JNK or p38 pathways inhibited apoptosis induced by arsenite, whereas expression of constitutive active mutants for either pathway induced apoptosis. arsenite 101-109 mitogen-activated protein kinase 8 Homo sapiens 50-53 10964950-11 2000 These data indicate that both JNK and p38 contribute to arsenite-induced apoptosis in primary CNS neurons, and this apoptosis requires the bcl-2-caspase pathway. arsenite 56-64 mitogen-activated protein kinase 8 Homo sapiens 30-33 10618720-1 1999 Arsenate and arsenite activate c-Jun N-terminal kinase (JNK), however, the mechanism by which this occurs is not known. arsenite 13-21 mitogen-activated protein kinase 8 Homo sapiens 31-54 10618720-1 1999 Arsenate and arsenite activate c-Jun N-terminal kinase (JNK), however, the mechanism by which this occurs is not known. arsenite 13-21 mitogen-activated protein kinase 8 Homo sapiens 56-59 10618720-2 1999 By expressing inhibitory mutant small GTP-binding proteins, p21-activated kinase (PAK) and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinases (MEKKs), we have identified specific proteins that are involved in arsenate- and arsenite-mediated activation of JNK. arsenite 258-266 mitogen-activated protein kinase 8 Homo sapiens 290-293 10618720-6 1999 Arsenite stimulation of JNK requires PAK, whereas arsenate-mediated activation of JNK was unaffected by inhibitory mutant PAK. arsenite 0-8 mitogen-activated protein kinase 8 Homo sapiens 24-27 10618720-8 1999 In contrast, arsenite-mediated JNK activation requires MEKK2, MEKK3 and MEKK4. arsenite 13-21 mitogen-activated protein kinase 8 Homo sapiens 31-34 10618720-9 1999 These results better define the mechanisms by which arsenate and arsenite activate JNK and demonstrate differences in the regulation of signal transduction pathways by these inorganic arsenic species. arsenite 65-73 mitogen-activated protein kinase 8 Homo sapiens 83-86 10329651-4 1999 Interestingly, arsenite induces Erk phosphorylation and increased Erk activity at doses ranging from 0.8 to 200 microM, while higher doses (more than 50 microM) are required for activation of JNK. arsenite 15-23 mitogen-activated protein kinase 8 Homo sapiens 192-195 10329651-7 1999 In contrast, overexpression of dominant negative JNK1 was shown to increase cell transformation even though it inhibits arsenite-induced JNK activation. arsenite 120-128 mitogen-activated protein kinase 8 Homo sapiens 49-53 10329651-7 1999 In contrast, overexpression of dominant negative JNK1 was shown to increase cell transformation even though it inhibits arsenite-induced JNK activation. arsenite 120-128 mitogen-activated protein kinase 8 Homo sapiens 49-52 34861471-0 2022 Arsenite-induced cytotoxicity is regulated by p38-SQSTM1/p62 and JNK-BNIP3L/Nix signaling in lung cancer cells. arsenite 0-8 mitogen-activated protein kinase 8 Homo sapiens 65-68 10082520-5 1999 Conversely, exposure of cells to heat shock and other protein-damaging conditions, including ethanol, arsenite, and oxidative stress, strongly reduced the rate of JNK dephosphorylation. arsenite 102-110 mitogen-activated protein kinase 8 Homo sapiens 163-166