PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22354777-0	2013	Phosphorylation of histone H3 at serine 10 has an essential role in arsenite-induced expression of FOS, EGR1 and IL8 mRNA in cultured human cell lines.	arsenite	68-76	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	99-102	
34425169-9	2021	A common element in the changing response of cells to arsenite over time appears to involve up-regulation of MDM2 by inflammatory signaling (through AP-1 and NF-kappaB), leading to inhibition of P53 function.	arsenite	54-62	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	149-153	
20006635-0	2010	Arsenite suppression of involucrin transcription through AP1 promoter sites in cultured human keratinocytes.	arsenite	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	57-60	
20006635-1	2010	While preserving keratinocyte proliferative ability, arsenite suppresses cellular differentiation markers by preventing utilization of AP1 transcriptional response elements.	arsenite	53-61	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	135-138	
20006635-2	2010	In present experiments, arsenite had a dramatic effect in electrophoretic mobility supershift analysis of proteins binding to an involucrin promoter AP1 response element.	arsenite	24-32	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	149-152	
20006635-5	2010	Immunoblotting of cell extracts showed that arsenite treatment prevented the loss of Fra1 and the increase in c-Fos proteins that occurred after confluence in untreated cultures.	arsenite	44-52	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	110-115	
11055208-14	2000	Through the JNK and p38 pathways, arsenite activates the immediate early genes c-fos, c-jun, and egr-1, usually activated by various growth factors, cytokines, differentiation signals, and DNA-damaging agents.	arsenite	34-42	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	79-84	
9920779-0	1999	c-fos induction by heat, arsenite, and cadmium is mediated by a heat shock element in its promoter.	arsenite	25-33	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5	
9920779-3	1999	In this report, we revealed that the human and rodent c-fos promoters do contain HSEs which are highly responsive to heat, arsenite, and cadmium.	arsenite	123-131	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	54-59	
8267588-3	1993	Stressors, including heat shock, arsenite and cadmium can induce c-fos transcription, but a heat shock element in the c-fos promoter has not been described.	arsenite	33-41	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-70	
8267588-4	1993	In this report we show that the induction of c-fos by heat shock, arsenite and cadmium can be mediated by the serum response element.	arsenite	66-74	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	45-50	
8267588-5	1993	Furthermore we show that casein kinase II, which has been proposed to be involved in serum induction via the serum response element, may also be involved in heat shock, arsenite and cadmium induction of c-fos.	arsenite	169-177	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	203-208	
8482719-4	1993	It is shown that the concentrations of arsenite that enhance the mitogenic effect of serum also increase the mRNA levels of c-fos, HSP68, and HSP84 and induce the specific synthesis of Heat Shock Proteins (HSPs).	arsenite	39-47	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	124-129	
12547826-0	2003	Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts.	arsenite	15-23	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	84-89	
12547826-3	2003	We have shown previously that arsenite can potently activate the mitogen-activated protein kinase cascades and induce the expression of proliferation-associated genes, including proto-oncogenes c-jun and c-fos.	arsenite	30-38	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	204-209	
12547826-4	2003	In order to elucidate further the molecular mechanisms underlying its tumor-promoting properties, we investigated the signaling events involved in arsenite-mediated induction of c-fos and c-jun.	arsenite	147-155	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	178-183	
12547826-5	2003	We found that induction of both c-fos and c-jun by arsenite can be substantially inhibited by the MEK- selective inhibitor U0126, suggesting that the ERK pathway is critically involved in their up-regulation.	arsenite	51-59	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	32-37	
12547826-6	2003	Interestingly, arsenite dramatically induced the phosphorylation and acetylation of histone H3 preceding the induction of mRNAs encoding c-fos and c-jun.	arsenite	15-23	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	137-142	
12547826-7	2003	Finally, chromatin immunoprecipitation assays revealed that arsenite treatment markedly induced the phosphorylation/acetylation of histone H3 associated with the c-fos and c-jun genes through an ERK-dependent pathway.	arsenite	60-68	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	162-167	
29350772-0	2018	Arsenite-induced histone H3 modification and its effects on EGR1 and FOS expression in HeLa cells.	arsenite	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	69-72	
3316977-1	1987	Several known inducers of the heat shock response (heat stress, arsenite, and heavy metals) were shown to cause a significant elevation of c-fos mRNA in HeLa cells.	arsenite	64-72	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	139-144	
3316977-4	1987	Treatment of HeLa cells with arsenite or heavy metals also resulted in increased levels of hsp 70, as well as c-fos mRNA.	arsenite	29-37	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	112-115