PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28984870-4	2018	Arsenite (Ars)-induced oxidative stress increased cellular GADD34 levels and enhanced Sirtuin 1 (SIRT1) recruitment to assemble a cytoplasmic complex containing GADD34, PP1alpha, eIF2alpha and SIRT1.	arsenite	0-8	eukaryotic translation initiation factor 2A	Homo sapiens	179-188	
15788408-11	2005	In addition, the ability of a thiol antioxidant, N-acetylcysteine, to inhibit the effect of arsenite on VEGF expression coincided with its ability to inhibit phosphorylation of eIF2alpha and ATF4 protein expression.	arsenite	92-100	eukaryotic translation initiation factor 2A	Homo sapiens	177-186	
12767237-7	2003	In addition, autophosphorylation of Thr485 was necessary for arsenite-induced activation of the eIF2alpha kinase activity of HRI, while autophosphorylation at Thr483 was not required for activation by arsenite.	arsenite	61-69	eukaryotic translation initiation factor 2A	Homo sapiens	96-105	
11809833-6	2002	Cells expressing a phosphomimetic mutant (S51D) of eIF2alpha assemble SGs of similar composition, confirming that the recruitment of these factors is a direct consequence of blocked translational initiation and not due to other effects of arsenite.	arsenite	239-247	eukaryotic translation initiation factor 2A	Homo sapiens	51-60	
11809833-7	2002	Surprisingly, phospho-eIF2alpha is recruited to SGs that are disassembling in cells recovering from arsenite-induced stress.	arsenite	100-108	eukaryotic translation initiation factor 2A	Homo sapiens	22-31	
11689689-6	2001	HRI is the only eIF2alpha kinase activated by arsenite in erythroid cells, since HRI-null cells do not induce eIF2alpha phosphorylation upon arsenite treatment.	arsenite	46-54	eukaryotic translation initiation factor 2A	Homo sapiens	16-25	
32506763-0	2020	ROS-mediated PERK-eIF2alpha-ATF4 pathway plays an important role in arsenite-induced L-02 cells apoptosis via regulating CHOP-DR5 signaling.	arsenite	68-76	eukaryotic translation initiation factor 2A	Homo sapiens	18-27	
15788408-7	2005	Arsenite induced eIF2alpha phosphorylation, resulting in increased ATF4 protein levels.	arsenite	0-8	eukaryotic translation initiation factor 2A	Homo sapiens	17-26	
8798781-10	1996	When incubated with double-stranded RNA, extracts derived from arsenite-treated cells displayed greater degrees of phosphorylation of PKR and eIF-2alpha than did control extracts.	arsenite	63-71	eukaryotic translation initiation factor 2A	Homo sapiens	142-152	
28984870-4	2018	Arsenite (Ars)-induced oxidative stress increased cellular GADD34 levels and enhanced Sirtuin 1 (SIRT1) recruitment to assemble a cytoplasmic complex containing GADD34, PP1alpha, eIF2alpha and SIRT1.	arsenite	0-3	eukaryotic translation initiation factor 2A	Homo sapiens	179-188	
28715409-6	2017	We demonstrate that ZIKV negatively impacts SG assembly under oxidative stress conditions induced by sodium arsenite (Ars), a treatment that leads to the phosphorylation of eIF2alpha.	arsenite	118-121	eukaryotic translation initiation factor 2A	Homo sapiens	173-182	
22872678-4	2012	Enhanced mutant fibulin-3 secretion can also be achieved by activation of a PERK-independent eIF2alpha kinase through arsenite treatment and is independent of activating transcription factor 4 signaling and protein translation.	arsenite	118-126	eukaryotic translation initiation factor 2A	Homo sapiens	93-102	
20154146-2	2010	We identified the human OGFOD1 protein as a novel stress granule component that regulates the phosphorylation of eIF2alpha and the resumption of translation in cells recovering from arsenite-induced stress.	arsenite	182-190	eukaryotic translation initiation factor 2A	Homo sapiens	113-122	
20154146-4	2010	Overexpression of OGFOD1 led to increased abundance of phosphorylated eIF2alpha, both in unstressed cells and in cells exposed to arsenite-induced stress, and to accelerated apoptosis during stress.	arsenite	130-138	eukaryotic translation initiation factor 2A	Homo sapiens	70-79	
20154146-7	2010	These findings argue that OGFOD1 plays important proapoptotic roles in the regulation of translation and HRI-mediated phosphorylation of eIF2alpha in cells subjected to arsenite-induced stress.	arsenite	169-177	eukaryotic translation initiation factor 2A	Homo sapiens	137-146