PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14534155-3	2003	This study was planned in order to investigate if ambroxol and its precursor bromhexine are actually capable of preventing alpha-1-antitrypsin (A1AT) inactivation by stimulated neutrophils and possibly to look into the mechanisms underlying this event.	Ambroxol	50-58	serpin family A member 1	Homo sapiens	123-142	
14534155-3	2003	This study was planned in order to investigate if ambroxol and its precursor bromhexine are actually capable of preventing alpha-1-antitrypsin (A1AT) inactivation by stimulated neutrophils and possibly to look into the mechanisms underlying this event.	Ambroxol	50-58	serpin family A member 1	Homo sapiens	144-148	
14534155-8	2003	Ambroxol prevented the A1AT inactivation by neutrophils, whereas bromhexine was completely ineffective.	Ambroxol	0-8	serpin family A member 1	Homo sapiens	23-27	
14534155-9	2003	Among drugs currently available for in vivo use in humans, ambroxol is unique by virtue of its ability to prevent neutrophil-mediated A1AT inactivation via inhibition of HOCl production as well as HOCl scavenging.	Ambroxol	59-67	serpin family A member 1	Homo sapiens	134-138	
12427115-0	2002	Ambroxol inhibits peroxynitrite-induced damage of alpha1-antiproteinase and free radical production in activated phagocytic cells.	Ambroxol	0-8	serpin family A member 1	Homo sapiens	50-71	
12427115-2	2002	Ambroxol decreased the inactivation or destruction of alpha1-antiproteinase induced by peroxynitrite (ONOO-) or hypochlorous acid (HOCl), which was similar to penicillamine and glutathione and was greater than diclofenac sodium and naproxen sodium.	Ambroxol	0-8	serpin family A member 1	Homo sapiens	54-75	
12427115-7	2002	Ambroxol may interfere with oxidative damage of alpha1-antiproteinase through a scavenging action on ONOO- and HOCl and inhibition of the respiratory burst of phagocytic cells.	Ambroxol	0-8	serpin family A member 1	Homo sapiens	48-69	
10556685-1	1999	Ambroxol (100 microM and 1 mM) and the thiols (all 1 mM), glutathione, tiopronin and cysteine, significantly attenuated the myeloperoxidase, H(2)O(2) and Cl(-) system-caused destruction of alpha(1)-antiproteinase and the HOCl-induced destruction of collagen, whereas they did not affect the elastase-induced destruction of collagen.	Ambroxol	0-8	serpin family A member 1	Homo sapiens	189-212	
10556685-6	1999	The results show that ambroxol may interfere with oxidative tissue damage and decrease proteolytic tissue destruction by attenuation of oxidative stress-induced inactivation of alpha(1)-antiproteinase through both decomposition of HOCl and inhibition of the respiratory burst in phagocytic cells.	Ambroxol	22-30	serpin family A member 1	Homo sapiens	177-200