PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10727524-0 2000 Loss of cyclosporin and azidopine binding are associated with altered ATPase activity by a mutant P-glycoprotein with deleted phe(335). Phenylalanine 126-129 ATP binding cassette subfamily B member 1 Homo sapiens 98-112 15542593-2 2005 The COOH terminus of P-gp contains a dileucine motif (Leu(1260)-Leu(1261)) and a conserved phenylalanine (Phe(1268)). Phenylalanine 91-104 ATP binding cassette subfamily B member 1 Homo sapiens 21-25 15542593-2 2005 The COOH terminus of P-gp contains a dileucine motif (Leu(1260)-Leu(1261)) and a conserved phenylalanine (Phe(1268)). Phenylalanine 106-109 ATP binding cassette subfamily B member 1 Homo sapiens 21-25 15247215-6 2004 Deletion of Phe-508 in the P-gp/CFTR chimera also inhibited cross-linking between the NBDs. Phenylalanine 12-15 ATP binding cassette subfamily B member 1 Homo sapiens 27-31 15292579-4 2004 It is suggested that PCB-126 decreased the drug efflux by inhibiting the P-glycoprotein in ${\text{KB3 - Phe} };{61} $. Phenylalanine 105-108 ATP binding cassette subfamily B member 1 Homo sapiens 73-87 12070134-7 2002 Deleting Phe(508) in the P-gp/CFTR chimera, however, caused defective processing of the mutant protein and no detectable cross-linking between TM4 or TM5 and TM12. Phenylalanine 9-12 ATP binding cassette subfamily B member 1 Homo sapiens 25-29 11328489-8 2001 Interestingly, N-methylation of the Phe-Ala peptide bond of the terminally modified tripeptide Ac-Ala-Phe-Ala-NH2 decreased the substrate activity of the molecule for the efflux transporter P-gp. Phenylalanine 36-39 ATP binding cassette subfamily B member 1 Homo sapiens 190-194 11328489-9 2001 In contrast, N-methylation of the Ala-Phe peptide bond of the terminally modified tripeptide Ac-Ala-Phe-Ala-NH2 increased the substrate activity of the molecule for P-gp. Phenylalanine 38-41 ATP binding cassette subfamily B member 1 Homo sapiens 165-169 10727524-10 2000 Phe(335) also plays a role in the coupling of verapamil binding and modulation of daunorubicin intracellular accumulation in wild-type P-gp. Phenylalanine 0-3 ATP binding cassette subfamily B member 1 Homo sapiens 135-139 10727524-12 2000 The deletion of Phe(335) results in a significant increase in the basal ATPase activity with a concomitant decrease in its ability to trap ATP and transport some P-gp substrates. Phenylalanine 16-19 ATP binding cassette subfamily B member 1 Homo sapiens 162-166 22439003-7 2012 CONCLUSIONS/SIGNIFICANCE: This accurate, fast and robust PhE/SVM model that can take into account the promiscuous nature of P-gp can be applied to predict the P-gp inhibition of structurally diverse compounds that otherwise cannot be done by any other methods in a high-throughput fashion to facilitate drug discovery and development by designing drug candidates with better metabolism profile. Phenylalanine 57-60 ATP binding cassette subfamily B member 1 Homo sapiens 124-128 22439003-7 2012 CONCLUSIONS/SIGNIFICANCE: This accurate, fast and robust PhE/SVM model that can take into account the promiscuous nature of P-gp can be applied to predict the P-gp inhibition of structurally diverse compounds that otherwise cannot be done by any other methods in a high-throughput fashion to facilitate drug discovery and development by designing drug candidates with better metabolism profile. Phenylalanine 57-60 ATP binding cassette subfamily B member 1 Homo sapiens 159-163 10727524-1 2000 In this study, we further characterize a mutant P-glycoprotein (P-gp) that has a deletion of Phe(335) and is resistant to inhibition by cyclosporins. Phenylalanine 93-96 ATP binding cassette subfamily B member 1 Homo sapiens 48-62 10727524-1 2000 In this study, we further characterize a mutant P-glycoprotein (P-gp) that has a deletion of Phe(335) and is resistant to inhibition by cyclosporins. Phenylalanine 93-96 ATP binding cassette subfamily B member 1 Homo sapiens 64-68 23104431-4 2013 Ten alanine mutants of human P-gp drug-binding amino acids-Leu(65), Ile(306), Phe(336), Ile(340), Phe(343), Phe(728), Phe(942), Thr(945), Leu(975), and Val(982)-were generated and expressed in HEK293 cells with a mammalian baculovirus system. Phenylalanine 78-81 ATP binding cassette subfamily B member 1 Homo sapiens 29-33 9038218-6 1997 DNA heteroduplex analysis and sequencing reveal a mutant mdr1 gene (deletion of a phenylalanine at amino acid residue 335) in the DxP cell line. Phenylalanine 82-95 ATP binding cassette subfamily B member 1 Homo sapiens 57-61 7904655-4 1994 Computer-generated three-dimensional model structures showed that a typical substrate, rhodamine 123, can intercalate between three to four phenylalanine side-chains in any of several Pgp TM helices with minimal protrusion of the drug into bulk lipid, and that five to six (of the 12 Pgp putative TM segments) helices can facilitate transport through creation of a sterically compatible pore. Phenylalanine 140-153 ATP binding cassette subfamily B member 1 Homo sapiens 184-187 8104183-0 1993 Functional consequences of phenylalanine mutations in the predicted transmembrane domain of P-glycoprotein. Phenylalanine 27-40 ATP binding cassette subfamily B member 1 Homo sapiens 92-106 8104183-1 1993 Site-directed mutagenesis was used to investigate whether phenylalanine residues in predicted transmembrane sequences play essential roles in the function of human P-glycoprotein. Phenylalanine 58-71 ATP binding cassette subfamily B member 1 Homo sapiens 164-178 8104183-7 1993 These results suggest that Phe-335 and Phe-978 play important roles in the recognition and transport of specific substrates by P-glycoprotein. Phenylalanine 27-30 ATP binding cassette subfamily B member 1 Homo sapiens 127-141 8104183-7 1993 These results suggest that Phe-335 and Phe-978 play important roles in the recognition and transport of specific substrates by P-glycoprotein. Phenylalanine 39-42 ATP binding cassette subfamily B member 1 Homo sapiens 127-141 28728917-5 2017 By employing computational analysis, 15 conserved residues in the drug-binding pocket of human P-gp that interact with substrates were identified and then substituted with tyrosine, including 11 phenylalanine (F72, F303, F314, F336, F732, F759, F770, F938, F942, F983, F994), two leucine (L339, L975), one isoleucine (I306), and one methionine (M949). Phenylalanine 195-208 ATP binding cassette subfamily B member 1 Homo sapiens 95-99 32695413-2 2020 Previous phenylalanine-to-alanine scanning mutagenesis of Pgp revealed that nearly all mutations retained full MDR function and still permitted substrate transport. Phenylalanine 9-22 ATP binding cassette subfamily B member 1 Homo sapiens 58-61 27566564-3 2016 We considered the typical acidic extracellular pH (pHe) of sarcomas, and found that doxorubicin (DXR) cytotoxicity is reduced in P-gp negative OS cells cultured at pHe 6.5 compared to standard 7.4. Phenylalanine 51-54 ATP binding cassette subfamily B member 1 Homo sapiens 129-133 27566564-3 2016 We considered the typical acidic extracellular pH (pHe) of sarcomas, and found that doxorubicin (DXR) cytotoxicity is reduced in P-gp negative OS cells cultured at pHe 6.5 compared to standard 7.4. Phenylalanine 164-167 ATP binding cassette subfamily B member 1 Homo sapiens 129-133 23104431-4 2013 Ten alanine mutants of human P-gp drug-binding amino acids-Leu(65), Ile(306), Phe(336), Ile(340), Phe(343), Phe(728), Phe(942), Thr(945), Leu(975), and Val(982)-were generated and expressed in HEK293 cells with a mammalian baculovirus system. Phenylalanine 98-101 ATP binding cassette subfamily B member 1 Homo sapiens 29-33 23104431-4 2013 Ten alanine mutants of human P-gp drug-binding amino acids-Leu(65), Ile(306), Phe(336), Ile(340), Phe(343), Phe(728), Phe(942), Thr(945), Leu(975), and Val(982)-were generated and expressed in HEK293 cells with a mammalian baculovirus system. Phenylalanine 98-101 ATP binding cassette subfamily B member 1 Homo sapiens 29-33 23104431-4 2013 Ten alanine mutants of human P-gp drug-binding amino acids-Leu(65), Ile(306), Phe(336), Ile(340), Phe(343), Phe(728), Phe(942), Thr(945), Leu(975), and Val(982)-were generated and expressed in HEK293 cells with a mammalian baculovirus system. Phenylalanine 98-101 ATP binding cassette subfamily B member 1 Homo sapiens 29-33 22888853-5 2013 Particularly, the flexibility of the side chains of aromatic residues (Phe and Tyr) allows them to form rotamers with different orientations in the binding pocket, which plays a critical role for the poly-specificity of the drug-binding cavity of P-gp. Phenylalanine 71-74 ATP binding cassette subfamily B member 1 Homo sapiens 247-251