PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16675661-6 2006 Analysis of mutations of amino acid residues adjacent to the selectivity filter led to identification of Phe-1013 and Tyr-1021, whose mutation causes substantial changes in DHP binding. Phenylalanine 105-108 dihydropyrimidinase Homo sapiens 173-176 16675661-8 2006 We propose that DHP binding stabilizes a nonconducting state containing a single Ca(2+) ion in the pore through which Phe-1013 and Tyr-1021 are energetically coupled. Phenylalanine 118-121 dihydropyrimidinase Homo sapiens 16-19 14660664-8 2004 First, unlike villin headpiece that contains a single buried salt bridge, DHP contains a buried charged cluster comprising residues Glu(39), Arg(66), Lys(70), and the C-terminal carboxylate of Phe(76). Phenylalanine 193-196 dihydropyrimidinase Homo sapiens 74-77 14993732-5 2004 We identified Phe(1112) and Ser(1115) in the pore-forming IIIS5-S6 linker region of the alpha(1C) subunit as critical determinants of the binding of dihydropyridines (DHP). Phenylalanine 14-17 dihydropyrimidinase Homo sapiens 167-170 14993732-7 2004 We proposed that Phe(1112) and Ser(1115) in the pore-forming IIIS5-S6 linker region is required for the stabilization of the Ca(2+) channel in the open state by Ca(2+) channel agonists and further proposed a novel model for the DHP-binding pocket of the alpha(1C) subunit. Phenylalanine 17-20 dihydropyrimidinase Homo sapiens 228-231 7601731-8 1995 Infusion of 2,3-DHP resulted in a plasma 2,3-DHP content of 9.4 mumol/L and increased plasma THR, ARG, VAL, PHE, ILE, LEU, and LYS concentrations (P < .10). Phenylalanine 108-111 dihydropyrimidinase Homo sapiens 16-19