PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 974262-5 1976 Substitution of the next residue, phenylalanine (CD1) beta 42 by serine (Hb Hammersmith), has resulted in chronic severe Heinz body hemolytic anemia. Phenylalanine 34-47 CD1c molecule Homo sapiens 49-52 4041267-0 1985 Functional properties of the unstable Hb-Torino: alpha 43 (CD-1) Phe-Val. Phenylalanine 65-68 CD1c molecule Homo sapiens 59-63 6877904-9 1983 Despite structural and functional similarities between Hb Cheverly and Hb Hammersmith, beta 42 (CD1) Phe-Ser, the clinical manifestations of Hb Cheverly are mild in contrast to the severe disease observed with Hb Hammersmith. Phenylalanine 101-104 CD1c molecule Homo sapiens 96-99 3781864-4 1986 Structural analyses revealed that the phenylalanine beta 42 (CD1), one of the critical amino acid residues in the heme pocket, had been replaced by valine. Phenylalanine 38-51 CD1c molecule Homo sapiens 61-64 6259091-0 1981 Hemoglobin Hammersmith (beta 42 (CD1) Phe replaced by Ser) associated with severe hemolytic anemia. Phenylalanine 38-41 CD1c molecule Homo sapiens 33-36 640848-0 1978 Hemoglobin Louisville (beta 42 (CD1) phenylalanine replaced by leucine) occurring as a fresh mutation in a Canadian woman. Phenylalanine 37-50 CD1c molecule Homo sapiens 32-35 826080-0 1976 A drug-induced haemolytic anaemia due to Hb Torino (alpha43(CD1)Phe replaced by Val). Phenylalanine 64-67 CD1c molecule Homo sapiens 60-63 939244-1 1976 A severely anaemic, but asymptomatic patient, who is a heterozygous carrier of haemoglobin Hammersmith (beta42 (CD1) phenylalanine - Serine), has been studied to elucidate the mechanisms resulting in physiological compensation for the anaemia. Phenylalanine 117-130 CD1c molecule Homo sapiens 112-115 826080-2 1976 The unstable haemoglobin, Tb Torino (alpha43(CD1)Phe replaced by Val), has been found for the second time in a family from the Treviso region of Italy. Phenylalanine 49-52 CD1c molecule Homo sapiens 45-48 1177282-1 1975 A new case of haemoglobin Bucuresti beta 42 (CD1) Phe yields Leu is described in a Cuban family. Phenylalanine 50-53 CD1c molecule Homo sapiens 45-48 5096522-0 1971 Hemoglobin Louisville (beta-42 (CD1) phe-leu): an unstable variant causing mild hemolytic anemia. Phenylalanine 37-40 CD1c molecule Homo sapiens 32-35 5133275-0 1971 Haemoglobin Buccuresti 42(CD1) Phe-Leu, a cause of unstable haemoglobin haemolytic anaemia. Phenylalanine 32-35 CD1c molecule Homo sapiens 27-30 30032685-0 2018 Hb Oslo [beta42(CD1)Phe Ile; HBB: c.127T>A]: A Novel Unstable Hemoglobin Variant Found in a Norwegian Patient. Phenylalanine 20-23 CD1c molecule Homo sapiens 16-19 5643522-0 1968 Haemoglobin Torino--alpha-43 (CD1) phenylalanine replaced by valine. Phenylalanine 35-48 CD1c molecule Homo sapiens 30-33 31299317-0 2019 Capillary electrophoresis and mutational images of hemoglobin sendagi [Beta42 (CD1) PHE VAL; HBB: C.127T G]. Phenylalanine 84-87 CD1c molecule Homo sapiens 79-82 30032685-4 2018 She was found to be carrier of a novel unstable Hb variant, Hb Oslo [beta42(CD1)Phe Ile (TTT>ATT), HBB: c.127T>A] located in the heme pocket of the beta-globin chain. Phenylalanine 80-83 CD1c molecule Homo sapiens 76-79 12672482-6 2003 The complete amino acid sequence of 157 residues of Theliostyla myoglobin shows that it has a long N-terminal extension of seven residues and contains three functional key residues: CD1-Phe, E7-His, and F8-His. Phenylalanine 186-189 CD1c molecule Homo sapiens 182-185 22217314-0 2012 A case report of a male patient with Hb Hammersmith [beta42(CD1)Phe Ser, TTT>TCT]. Phenylalanine 64-67 CD1c molecule Homo sapiens 60-63 22217314-1 2012 All Hb Hammersmith [beta42(CD1)Phe Ser, TTT>TCT] patients reported so far have been female, suggesting that this condition may occur as a negative, fatal intrauterine selection against males. Phenylalanine 31-34 CD1c molecule Homo sapiens 27-30 16078214-0 2006 Hemoglobin Hammersmith [beta 42(CD1) Phe --> Ser] causing severe hemolytic anemia in a Japanese girl. Phenylalanine 37-40 CD1c molecule Homo sapiens 32-35 16547137-9 2006 Damping of the heme response appears to result from a strain exerted by the E-helix via the CD-turn; Phe-43(CD1), in close contact with heme, opposes tilt until the strain is relieved. Phenylalanine 101-104 CD1c molecule Homo sapiens 108-111 24471820-0 2014 Case report: prenatal diagnosis of Hb Hammersmith [beta42(CD1)Phe Ser; HBB: c.128T > C] in a family with an adult male patient. Phenylalanine 62-65 CD1c molecule Homo sapiens 58-61 24471820-1 2014 Hb Hammersmith [beta42(CD1)Phe Ser; HBB: c.128T > C] is a rare, unstable hemoglobin (Hb) variant. Phenylalanine 27-30 CD1c molecule Homo sapiens 23-26 16078214-5 2006 DNA sequence analysis of the polymerase chain reaction-amplified beta-globin gene revealed a point mutation (T --> C) in the second nucleotide of the 42nd codon of the beta-globin chain (beta 42(CD1) Phe --> Ser). Phenylalanine 203-206 CD1c molecule Homo sapiens 190-201 16619220-0 2006 Hemoglobin Hammersmith [beta42 (CD1) Phe --> Ser] in a Brazilian girl with congenital Heinz body hemolytic anemia. Phenylalanine 37-40 CD1c molecule Homo sapiens 32-35 9856680-0 1998 Hb Hammersmith [beta 42(CD1) Phe-->Ser]: occurrence as a de novo mutation in black monozygotic twins with multiple congenital anomalies. Phenylalanine 29-32 CD1c molecule Homo sapiens 24-27 9856680-7 1998 CONCLUSION: This report describes the occurrence of Hb Hammersmith [B42(CD1)Phe-->Ser] in African-American twins. Phenylalanine 76-79 CD1c molecule Homo sapiens 72-75 2294098-0 1990 Hemoglobin Warsaw (Phe beta 42(CD1)----Val), an unstable variant with decreased oxygen affinity. Phenylalanine 19-22 CD1c molecule Homo sapiens 31-34 2294098-2 1990 In Hb Warsaw Val replaces the Phe normally present at the heme contact position beta 42 (CD1). Phenylalanine 30-33 CD1c molecule Homo sapiens 89-92 10448045-2 1999 The first is the well-known "functional" cluster which includes six heme-binding conserved residues (Phe CD1, His F8; aliphatic E11, FG5; hydrophobic F4, G5) and seven other conserved residues (Pro C2; aliphatic H19; hydrophobic B10, B13, B14, CD4, E4) that do not bind the heme but belong to its immediate neighborhood. Phenylalanine 101-104 CD1c molecule Homo sapiens 105-108 1634359-0 1992 The unstable Hb Hammersmith or alpha 2 beta 2(42)(CD1)Phe----Ser observed in an Indian child; identification by HPLC and by sequence analysis of amplified DNA. Phenylalanine 54-60 CD1c molecule Homo sapiens 50-53 1634359-1 1992 We have identified the unstable hemoglobin variant present in a Chipewayan Indian patient with severe hemolytic anemia as Hb Hammersmith or alpha 2 beta 2(42)(CD1)Phe----Ser. Phenylalanine 163-166 CD1c molecule Homo sapiens 159-162