PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30634150-5	2019	The release of pro-inflammatory cytokines interleukin 6 and tumor necrosis factor alpha was also elevated in BaP-treated offspring.	Benzo(a)pyrene	109-112	tumor necrosis factor	Mus musculus	15-87	
16307768-10	2006	Although TNFalpha and CYP1B1 are implicated as essential mediators of hypocellularity, the similar induction of TNFalpha mRNA and CYP1B1 mRNA in the BM by BP and DMBA suggests that they are not limiting factors in mediating the different effects of these PAHs.	Benzo(a)pyrene	155-157	tumor necrosis factor	Mus musculus	112-120	
9815112-3	1998	In this study, we demonstrate that cultured macrophages (RAW 264.7 cells) exposed continously to a well-defined model of PM [benzo[a]pyrene adsorbed on carbon black (CB+BaP)] exhibit a time-dependent expression and release of the cytokine tumor necrosis factor-alpha (TNF-alpha).	Benzo(a)pyrene	125-139	tumor necrosis factor	Mus musculus	239-266	
34216713-9	2021	Exposure to BaP/DSS also significantly elevated TNF-alpha levels, and the administration of 5-DMNB reversed this increase.	Benzo(a)pyrene	12-15	tumor necrosis factor	Mus musculus	48-57	
9815112-3	1998	In this study, we demonstrate that cultured macrophages (RAW 264.7 cells) exposed continously to a well-defined model of PM [benzo[a]pyrene adsorbed on carbon black (CB+BaP)] exhibit a time-dependent expression and release of the cytokine tumor necrosis factor-alpha (TNF-alpha).	Benzo(a)pyrene	125-139	tumor necrosis factor	Mus musculus	268-277	
35057794-10	2022	RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR.	Benzo(a)pyrene	13-16	tumor necrosis factor	Mus musculus	303-312	
35057794-10	2022	RESULTS: (1) BaP inhibited body weight gain, decreased lipid content, increased lipid levels, and decreased glucose tolerance and insulin tolerance in mice; (2) BaP reduced the expressions of C/EBPalpha, PPARgamma, FABP4, PGC-1alpha, and PPARalpha and increased the expressions of NF-kappaB, MCP-1, and TNF-alpha by activating AhR.	Benzo(a)pyrene	161-164	tumor necrosis factor	Mus musculus	303-312	
30099064-7	2018	In contrast, the release of tumor necrosis factor (TNF)-alpha and IL-10 was increased following BaP exposure.	Benzo(a)pyrene	96-99	tumor necrosis factor	Mus musculus	28-61	
25233930-2	2014	We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells.	Benzo(a)pyrene	237-251	tumor necrosis factor	Mus musculus	103-130	
29534036-2	2018	BaP enhanced the INFG, especially MCP-1 and TNFalpha.	Benzo(a)pyrene	0-3	tumor necrosis factor	Mus musculus	44-52	
29534036-3	2018	Co-exposure to BaP and PCB153 showed a synergistic effect on TNFalpha and IL6 expression.	Benzo(a)pyrene	15-18	tumor necrosis factor	Mus musculus	61-69	
29534036-4	2018	Treatment with BaP and PCBs during only the maturation period up-regulated the INFG (IL6, TNFalpha, CXCL-10 & MCP-1).	Benzo(a)pyrene	15-18	tumor necrosis factor	Mus musculus	90-98	
25233930-2	2014	We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells.	Benzo(a)pyrene	237-251	tumor necrosis factor	Mus musculus	132-141	
25233930-2	2014	We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells.	Benzo(a)pyrene	253-256	tumor necrosis factor	Mus musculus	103-130	
25233930-2	2014	We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and the aryl hydrocarbon receptor ligands, may increase bioactivation of promutagens, such as benzo[a]pyrene (BaP) in epithelial cells.	Benzo(a)pyrene	253-256	tumor necrosis factor	Mus musculus	132-141	
22735861-6	2012	RESULTS: Hematological parameters and the histochemical analysis of mast cells showed abnormal changes, and the immunoblotting analysis revealed increased protein expression of TNF-alpha, IL-6, COX-2 and NF-kappaB in lung cancer-challenged mice administered with benzo(a)pyrene.	Benzo(a)pyrene	263-277	tumor necrosis factor	Mus musculus	177-186	
20412841-5	2010	The treatment of HFD with BaP enhanced the expression of IL-1beta in the liver and TNFalpha throughout the bowel and in the liver.	Benzo(a)pyrene	26-29	tumor necrosis factor	Mus musculus	83-91