PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11096091-0 2001 Aromatic hydrocarbon receptor (AhR).AhR nuclear translocator- and p53-mediated induction of the murine multidrug resistance mdr1 gene by 3-methylcholanthrene and benzo(a)pyrene in hepatoma cells. Benzo(a)pyrene 162-176 transformation related protein 53, pseudogene Mus musculus 66-69 11096091-8 2001 Benzo(a)pyrene, a polycyclic aromatic hydrocarbon and AhR ligand, which, like 3-MC, is oxidized by metabolizing enzymes regulated by AhR.Arnt, also activated p53 and induced mdr1 transcription. Benzo(a)pyrene 0-14 transformation related protein 53, pseudogene Mus musculus 158-161 11096091-10 2001 These results indicate that the transcriptional induction of mdr1 by 3-MC and benzo(a)pyrene is directly mediated by p53 but that the metabolic activation of these compounds into reactive species is necessary to trigger p53 activation. Benzo(a)pyrene 78-92 transformation related protein 53, pseudogene Mus musculus 117-120 11195457-7 2000 We found that mice with the p53 mutation, on an A/J F1 background, were more susceptible to a number of potential lung carcinogens, including N-methyl-N-nitrosourea (MNU) and the known tobacco carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo(a)pyrene (BP). Benzo(a)pyrene 262-276 transformation related protein 53, pseudogene Mus musculus 28-31 11195457-7 2000 We found that mice with the p53 mutation, on an A/J F1 background, were more susceptible to a number of potential lung carcinogens, including N-methyl-N-nitrosourea (MNU) and the known tobacco carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo(a)pyrene (BP). Benzo(a)pyrene 278-280 transformation related protein 53, pseudogene Mus musculus 28-31 8055640-0 1994 Murine squamous cell carcinoma cell lines produced by a complete carcinogenesis protocol with benzo[a]pyrene exhibit characteristic p53 mutations and the absence of H-ras and cyl 1/cyclin D1 abnormalities. Benzo(a)pyrene 94-108 transformation related protein 53, pseudogene Mus musculus 132-135 10469621-0 1999 Thapsigargin has similar effect on p53 protein response to benzo[a]pyrene-DNA adducts as TPA in mouse skin. Benzo(a)pyrene 59-73 transformation related protein 53, pseudogene Mus musculus 35-38 10469621-1 1999 The level of p53 tumor suppressor protein increases in response to DNA damage caused by benzo[a]pyrene (B[a]P). Benzo(a)pyrene 88-102 transformation related protein 53, pseudogene Mus musculus 13-16 10469621-4 1999 We also studied the localization of p53 protein after treatments with BP and TPA or thapsigargin. Benzo(a)pyrene 70-72 transformation related protein 53, pseudogene Mus musculus 36-39 9051119-0 1996 Cell proliferation and nuclear abnormalities are increased and apoptosis is decreased in the epidermis of the p53 null mouse after topical application of benzo[a]pyrene. Benzo(a)pyrene 154-168 transformation related protein 53, pseudogene Mus musculus 110-113 8681459-0 1996 TPA decreases the p53 response to benzo[a]pyrene-DNA adducts in vivo in mouse skin. Benzo(a)pyrene 34-48 transformation related protein 53, pseudogene Mus musculus 18-21 8681459-2 1996 A dose-dependent increase in both the level of BPDE-DNA adducts and nuclear p53 immunoreactivity was found in mice treated topically with 50-750 microg benzo[a]pyrene. Benzo(a)pyrene 152-166 transformation related protein 53, pseudogene Mus musculus 76-79 7663513-2 1995 We have studied the effects of the environmental teratogen, benzo[a]pyrene, on pregnant heterozygous p53-deficient mice. Benzo(a)pyrene 60-74 transformation related protein 53, pseudogene Mus musculus 101-104 9006915-0 1997 A benzo[a]pyrene-induced cell cycle checkpoint resulting in p53-independent G1 arrest in 3T3 fibroblasts. Benzo(a)pyrene 2-16 transformation related protein 53, pseudogene Mus musculus 60-63 24705375-5 2014 Also, a significant increase in the protein expression of phosphorylated p53[ser15] confirmed p53 hyper-phosphorylation in BP treated mice. Benzo(a)pyrene 123-125 transformation related protein 53, pseudogene Mus musculus 73-76 27608907-7 2016 On the other hand, protein expressions of acetylated (lys382)-p53 were significantly decreased, following BP treatment. Benzo(a)pyrene 106-108 transformation related protein 53, pseudogene Mus musculus 62-65 27608907-10 2016 Supplementation of zinc to BP treated mice stimulated acetylation of p53 as observed by an increase in the protein expression of acetylated (lys382)-p53. Benzo(a)pyrene 27-29 transformation related protein 53, pseudogene Mus musculus 69-72 27608907-10 2016 Supplementation of zinc to BP treated mice stimulated acetylation of p53 as observed by an increase in the protein expression of acetylated (lys382)-p53. Benzo(a)pyrene 27-29 transformation related protein 53, pseudogene Mus musculus 149-152 28681665-5 2018 Curcumin and quercetin when administered individually as well as in combination significantly elevated the expression of acetylated-p53, which was otherwise depressed due to BP treatment. Benzo(a)pyrene 174-176 transformation related protein 53, pseudogene Mus musculus 132-135 28681665-6 2018 Also, both the phytochemicals significantly reduced the BP-inflicted increased levels of phosphorylated-p53. Benzo(a)pyrene 56-58 transformation related protein 53, pseudogene Mus musculus 104-107 26709117-3 2016 BaP induced DNA damage and over expression in p53 cervical tissue of mice as demonstrated in our previous study. Benzo(a)pyrene 0-3 transformation related protein 53, pseudogene Mus musculus 46-49 26679980-0 2016 Subchronic exposure of benzo(a)pyrene interferes with the expression of Bcl-2, Ki-67, C-myc and p53, Bax, Caspase-3 in sub-regions of cerebral cortex and hippocampus. Benzo(a)pyrene 23-37 transformation related protein 53, pseudogene Mus musculus 96-99 24705375-5 2014 Also, a significant increase in the protein expression of phosphorylated p53[ser15] confirmed p53 hyper-phosphorylation in BP treated mice. Benzo(a)pyrene 123-125 transformation related protein 53, pseudogene Mus musculus 94-97 24705375-9 2014 Interestingly, combined treatment of curcumin and resveratrol to BP treated animals resulted in a significant decrease in p53 hyper-phosphorylation, 14C glucose uptakes/turnover and 3H-thymidine uptake in the BP treated mice. Benzo(a)pyrene 65-67 transformation related protein 53, pseudogene Mus musculus 122-125 21715664-0 2011 Deregulation of cancer-related pathways in primary hepatocytes derived from DNA repair-deficient Xpa-/-p53+/- mice upon exposure to benzo[a]pyrene. Benzo(a)pyrene 132-146 transformation related protein 53, pseudogene Mus musculus 103-106 22828138-0 2012 Benzo[a]pyrene (BP) DNA adduct formation in DNA repair-deficient p53 haploinsufficient [Xpa(-/-)p53(+/-)] and wild-type mice fed BP and BP plus chlorophyllin for 28 days. Benzo(a)pyrene 0-14 transformation related protein 53, pseudogene Mus musculus 65-68 22828138-0 2012 Benzo[a]pyrene (BP) DNA adduct formation in DNA repair-deficient p53 haploinsufficient [Xpa(-/-)p53(+/-)] and wild-type mice fed BP and BP plus chlorophyllin for 28 days. Benzo(a)pyrene 16-18 transformation related protein 53, pseudogene Mus musculus 65-68 22828138-3 2012 When mice were fed 100 ppm BP for 28 days, BP-induced DNA damage measured in esophagus, liver and lung was typically higher in Xpa(-/-)p53(+/-) mice, compared with WT mice. Benzo(a)pyrene 27-29 transformation related protein 53, pseudogene Mus musculus 135-138 22828138-3 2012 When mice were fed 100 ppm BP for 28 days, BP-induced DNA damage measured in esophagus, liver and lung was typically higher in Xpa(-/-)p53(+/-) mice, compared with WT mice. Benzo(a)pyrene 43-45 transformation related protein 53, pseudogene Mus musculus 135-138 21745588-0 2011 A common carcinogen benzo[a]pyrene causes p53 overexpression in mouse cervix via DNA damage. Benzo(a)pyrene 20-34 transformation related protein 53, pseudogene Mus musculus 42-45 21745588-3 2011 The present study detected DNA damage and the expression of the p53 gene in BaP-induced cervical tissue in female mice. Benzo(a)pyrene 76-79 transformation related protein 53, pseudogene Mus musculus 64-67 21745588-9 2011 The results demonstrate that BaP may show toxic effect on the cervix by increasing DNA damage and the expression of the p53 gene. Benzo(a)pyrene 29-32 transformation related protein 53, pseudogene Mus musculus 120-123 24412381-8 2014 In addition, BaP exposure significantly reduced the expression of Xrcc5, p53, and DNA-PKcs in lung. Benzo(a)pyrene 13-16 transformation related protein 53, pseudogene Mus musculus 73-76 12733653-9 2003 We found that cells containing BPDE-DNA adducts and nuclear p53 expression significantly increased between 2 and 10 weeks of BaP-UVA treatment, whereas neither BPDE-DNA adducts nor significant changes in p53 were observed in untreated skin. Benzo(a)pyrene 125-128 transformation related protein 53, pseudogene Mus musculus 60-63 20103645-5 2010 Analysis of skin from wild-type and DKO mice exposed to BP for 6, 12, or 24 hours revealed a relative delay in the activation of p53, p63, p19ARF, and apoptosis in DKO mice, consistent with a negative modifier role for NQO1/NQO2 in carcinogenesis. Benzo(a)pyrene 56-58 transformation related protein 53, pseudogene Mus musculus 129-132 17433523-2 2007 In this study, we showed that B[a]P induces apoptosis in a p53-mediated and caspase-3-dependent manner, which relates to the accumulation of the S phase of the cell cycle. Benzo(a)pyrene 30-35 transformation related protein 53, pseudogene Mus musculus 59-62 16254190-3 2005 Topical application to wild-type mice with benzo(a)pyrene (BaP) alone produced approximately 26% skin tumor incidence, whereas BaP treatment of p53(wt/wt)Hras(TG.AC/wt), p53(Val135/wt)Hras(wt/wt), and p53(Val135/wt)Hras(TG.AC/wt) mice produced a 75%, 77%, and 100% incidence of skin tumors, respectively. Benzo(a)pyrene 127-130 transformation related protein 53, pseudogene Mus musculus 144-147 15449320-1 2004 The reactive metabolites of benzo[a]pyrene (B[a]P) and cyclopenta[c,d]pyrene (CPP) induced an accumulation/phosphorylation of p53 in Hepa1c1c7 cells, whereas inhibition of p53 reduced the apoptosis. Benzo(a)pyrene 28-42 transformation related protein 53, pseudogene Mus musculus 126-129 15449320-1 2004 The reactive metabolites of benzo[a]pyrene (B[a]P) and cyclopenta[c,d]pyrene (CPP) induced an accumulation/phosphorylation of p53 in Hepa1c1c7 cells, whereas inhibition of p53 reduced the apoptosis. Benzo(a)pyrene 28-42 transformation related protein 53, pseudogene Mus musculus 172-175 15449320-1 2004 The reactive metabolites of benzo[a]pyrene (B[a]P) and cyclopenta[c,d]pyrene (CPP) induced an accumulation/phosphorylation of p53 in Hepa1c1c7 cells, whereas inhibition of p53 reduced the apoptosis. Benzo(a)pyrene 44-49 transformation related protein 53, pseudogene Mus musculus 126-129 15449320-1 2004 The reactive metabolites of benzo[a]pyrene (B[a]P) and cyclopenta[c,d]pyrene (CPP) induced an accumulation/phosphorylation of p53 in Hepa1c1c7 cells, whereas inhibition of p53 reduced the apoptosis. Benzo(a)pyrene 44-49 transformation related protein 53, pseudogene Mus musculus 172-175 18248503-0 2008 p53 gene mutations in SKH-1 mouse tumors differentially induced by UVB and combined subcarcinogenic benzo[a]pyrene and UVA. Benzo(a)pyrene 100-114 transformation related protein 53, pseudogene Mus musculus 0-3 18248503-17 2008 We show that individually subcarcinogenic levels of BaP and UVA synergistically induce a novel p53-mutation fingerprint. Benzo(a)pyrene 52-55 transformation related protein 53, pseudogene Mus musculus 95-98 19105532-0 2008 Immunohistochemical study of fibrosis and adenocarcinoma in dominant-negative p53 transgenic mice exposed to chrysotile asbestos and benzo(a)pyrene. Benzo(a)pyrene 133-147 transformation related protein 53, pseudogene Mus musculus 78-81 19105532-1 2008 We evaluated the mechanisms using immunohistochemistry whereby chrysotile asbestos and benzo(a)pyrene (BaP) instilled intratracheally into lung-specific dominant-negative p53 (dnp53) mice might interact in causing lung carcinomas and fibrosis. Benzo(a)pyrene 87-101 transformation related protein 53, pseudogene Mus musculus 171-174 16244358-1 2006 DNA damage caused by benzo[a]pyrene (B[a]P) or other polynuclear hydrocarbons (PAHs) induce p53 protein as a protective measure to eliminate the possibility of mutagenic fixation of the DNA damage. Benzo(a)pyrene 21-35 transformation related protein 53, pseudogene Mus musculus 92-95 16244358-1 2006 DNA damage caused by benzo[a]pyrene (B[a]P) or other polynuclear hydrocarbons (PAHs) induce p53 protein as a protective measure to eliminate the possibility of mutagenic fixation of the DNA damage. Benzo(a)pyrene 37-42 transformation related protein 53, pseudogene Mus musculus 92-95 16297369-8 2005 The current data collectively indicate that BaP induces apoptosis of Hepa1c1c7 cells via activation of p53-related signaling, which was, in part, regulated by p38 kinase. Benzo(a)pyrene 44-47 transformation related protein 53, pseudogene Mus musculus 103-106 15641149-8 2005 CONCLUSION: Polysaccharides isolated from PG may inhibit BaP-induced forestomach carcinogenesis in mice bydown-regulating mutant p53 expression. Benzo(a)pyrene 57-60 transformation related protein 53, pseudogene Mus musculus 129-132 16050805-7 2005 We serially examined the histopathological changes in the lung of mice administered benzo(a)pyrene and correlated them with the frequency of proliferative and apoptotic cells in situ as well as with the expression of H-ras, c-Myc, p53, and Bcl-2 genes, which play key roles in the histopathogenesis of neoplasia. Benzo(a)pyrene 84-98 transformation related protein 53, pseudogene Mus musculus 231-234 15125997-5 2004 BaP also induced the mitochondrial dysfunction, including transition of mitochondria membrane potential and cytosolic release of cytochrome c. Furthermore, a decrease in the expression of Bcl-2 to Bax ratio and phosphorylation of p53(Ser 15) were observed in BaP-treated cells. Benzo(a)pyrene 0-3 transformation related protein 53, pseudogene Mus musculus 230-233 15125997-5 2004 BaP also induced the mitochondrial dysfunction, including transition of mitochondria membrane potential and cytosolic release of cytochrome c. Furthermore, a decrease in the expression of Bcl-2 to Bax ratio and phosphorylation of p53(Ser 15) were observed in BaP-treated cells. Benzo(a)pyrene 259-262 transformation related protein 53, pseudogene Mus musculus 230-233 15125997-6 2004 Taken together, these results demonstrated that BaP-induced apoptosis of Hepa1c1c7 cells via activation of intrinsic caspase pathway including caspase-3, caspase-9, with mitochondrial dysfunction and p53 activation. Benzo(a)pyrene 48-51 transformation related protein 53, pseudogene Mus musculus 200-203 12151310-9 2002 These results suggest that p53 function is important for protecting mice from both spontaneous and BaP-induced lung cancers. Benzo(a)pyrene 99-102 transformation related protein 53, pseudogene Mus musculus 27-30