PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18336843-0	2008	Tumor necrosis factor-alpha potentiates genotoxic effects of benzo[a]pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression.	Benzo(a)pyrene	61-75	tumor necrosis factor	Rattus norvegicus	0-27	
34488261-7	2021	While the level of TNF-alpha in each exposure group was higher than those in the blank control group and the levels of TNF-alpha in the DBP and BaP co-exposed groups were strongly augmented compared to those in the low and high dose groups that single-exposed to DBP and BaP (P<0.05) .	Benzo(a)pyrene	144-147	tumor necrosis factor	Rattus norvegicus	19-28	
34488261-7	2021	While the level of TNF-alpha in each exposure group was higher than those in the blank control group and the levels of TNF-alpha in the DBP and BaP co-exposed groups were strongly augmented compared to those in the low and high dose groups that single-exposed to DBP and BaP (P<0.05) .	Benzo(a)pyrene	144-147	tumor necrosis factor	Rattus norvegicus	119-128	
34488261-7	2021	While the level of TNF-alpha in each exposure group was higher than those in the blank control group and the levels of TNF-alpha in the DBP and BaP co-exposed groups were strongly augmented compared to those in the low and high dose groups that single-exposed to DBP and BaP (P<0.05) .	Benzo(a)pyrene	271-274	tumor necrosis factor	Rattus norvegicus	19-28	
34488261-7	2021	While the level of TNF-alpha in each exposure group was higher than those in the blank control group and the levels of TNF-alpha in the DBP and BaP co-exposed groups were strongly augmented compared to those in the low and high dose groups that single-exposed to DBP and BaP (P<0.05) .	Benzo(a)pyrene	271-274	tumor necrosis factor	Rattus norvegicus	119-128	
34488261-13	2021	After BaP exposed alone, the NF-kappaB p65 protein expression level was positively correlated with TNF-alpha and ALT (r=0.911 and 0.910, P<0.05) .	Benzo(a)pyrene	6-9	tumor necrosis factor	Rattus norvegicus	99-108	
28264426-10	2017	BP reduced hepatic inflammation and apoptosis by affecting IL-6 (interleukin 6), TNF-alpha (Tumor necrosis factor alpha), caspase-3 and Bcl-2 in NASH models.	Benzo(a)pyrene	0-2	tumor necrosis factor	Rattus norvegicus	81-90	
28264426-10	2017	BP reduced hepatic inflammation and apoptosis by affecting IL-6 (interleukin 6), TNF-alpha (Tumor necrosis factor alpha), caspase-3 and Bcl-2 in NASH models.	Benzo(a)pyrene	0-2	tumor necrosis factor	Rattus norvegicus	92-119	
34488261-14	2021	When DBP and BaP exposed together, NF-kappaB p65 protein expression level was positively correlated with CXCL-13, IL-6, TNF-alpha, ALT and AST (r=0.711, 0.764, 0.955, 0.903 and 0.827, P<0.05) .	Benzo(a)pyrene	13-16	tumor necrosis factor	Rattus norvegicus	120-129	
34488261-15	2021	In addition, Pearson correlation analysis showed a positive correlation between TNF-alpha and ALT (r=0.833 and 0.894, P<0.05) when DBP or BaP exposed alone.	Benzo(a)pyrene	138-141	tumor necrosis factor	Rattus norvegicus	80-89	
32046055-10	2020	In addition, we found BaP plus curcumin treatment effectively reduced inflammatory cytokines Tumour Necrosis Factor alpha (TNF-alpha), Interleukin 6 (IL-6), and C-reactive protein (CRP) levels in blood serum.	Benzo(a)pyrene	22-25	tumor necrosis factor	Rattus norvegicus	123-132	
24025706-2	2013	Previously, we have observed that tumor necrosis factor-alpha (TNF-alpha), a major pro-inflammatory cytokine, enhances genotoxicity of benzo[a]pyrene (B[a]P), a highly carcinogenic polycyclic aromatic hydrocarbon, in rat lung epithelial RLE-6TN cells, a model of alveolar type II cells.	Benzo(a)pyrene	135-149	tumor necrosis factor	Rattus norvegicus	34-61	
24025706-2	2013	Previously, we have observed that tumor necrosis factor-alpha (TNF-alpha), a major pro-inflammatory cytokine, enhances genotoxicity of benzo[a]pyrene (B[a]P), a highly carcinogenic polycyclic aromatic hydrocarbon, in rat lung epithelial RLE-6TN cells, a model of alveolar type II cells.	Benzo(a)pyrene	135-149	tumor necrosis factor	Rattus norvegicus	63-72	
18336843-5	2008	TNF-alpha enhanced induction of CYP1B1, while it simultaneously suppressed the BaP-induced CYP1A1 expression.	Benzo(a)pyrene	79-82	tumor necrosis factor	Rattus norvegicus	0-9	
18336843-8	2008	Inhibition of CYP1B1 by fluoranthene significantly decreased both the formation of DNA adducts and the induction of apoptosis in WB-F344 cells treated with BaP and TNF-alpha, thus suggesting that this isoform might be responsible for genotoxic effects of BaP in nonparenchymal liver cells.	Benzo(a)pyrene	255-258	tumor necrosis factor	Rattus norvegicus	164-173	
17991490-9	2007	Benzo(a)pyrene also induced TNF-alpha and IL-1beta production in PMNs, which was significantly reversed by genistein.	Benzo(a)pyrene	0-14	tumor necrosis factor	Rattus norvegicus	28-37