PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25995008-2 2016 Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the cytochrome P450 (CYP) 1A1-mediated biotransformation of BaP in vitro. Benzo(a)pyrene 132-135 tumor protein p53 Homo sapiens 34-37 28247504-3 2017 Co-treatment with 5 microM BaP and 20 microM EGCG in BEAS-2B promoted a significant reduction in cell viability and greater G2/M cell cycle arrest, induction of ROS, and reductions in BaP-induced CYP1A1/CYP1B1/COMT, EGFR, p-Akt (Ser473), p-p53 (Thr55), and survivin mRNA/protein expression, as well as an increase in p-p53 (Ser15). Benzo(a)pyrene 27-30 tumor protein p53 Homo sapiens 240-243 28247504-3 2017 Co-treatment with 5 microM BaP and 20 microM EGCG in BEAS-2B promoted a significant reduction in cell viability and greater G2/M cell cycle arrest, induction of ROS, and reductions in BaP-induced CYP1A1/CYP1B1/COMT, EGFR, p-Akt (Ser473), p-p53 (Thr55), and survivin mRNA/protein expression, as well as an increase in p-p53 (Ser15). Benzo(a)pyrene 27-30 tumor protein p53 Homo sapiens 319-322 25995008-2 2016 Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the cytochrome P450 (CYP) 1A1-mediated biotransformation of BaP in vitro. Benzo(a)pyrene 116-130 tumor protein p53 Homo sapiens 34-37 25995008-2 2016 Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the cytochrome P450 (CYP) 1A1-mediated biotransformation of BaP in vitro. Benzo(a)pyrene 116-130 tumor protein p53 Homo sapiens 175-178 28882572-7 2017 Validation studies confirmed the role of p53 in reducing gamma-H2AX formation and DNA breaks measured by COMET assay after BaP and AFB1 exposure. Benzo(a)pyrene 123-126 tumor protein p53 Homo sapiens 41-44 25995008-2 2016 Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the cytochrome P450 (CYP) 1A1-mediated biotransformation of BaP in vitro. Benzo(a)pyrene 132-135 tumor protein p53 Homo sapiens 175-178 25995008-2 2016 Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the cytochrome P450 (CYP) 1A1-mediated biotransformation of BaP in vitro. Benzo(a)pyrene 242-245 tumor protein p53 Homo sapiens 34-37 25398514-8 2016 CYP1A1 is inducible via the aryl hydrocarbon receptor (AHR), but we did not find that expression of AHR was dependent on p53; rather, we found that BaP-induced CYP1A1 expression was regulated through p53 binding to a p53 response element in the CYP1A1 promoter region, thereby enhancing its transcription. Benzo(a)pyrene 148-151 tumor protein p53 Homo sapiens 200-203 25398514-8 2016 CYP1A1 is inducible via the aryl hydrocarbon receptor (AHR), but we did not find that expression of AHR was dependent on p53; rather, we found that BaP-induced CYP1A1 expression was regulated through p53 binding to a p53 response element in the CYP1A1 promoter region, thereby enhancing its transcription. Benzo(a)pyrene 148-151 tumor protein p53 Homo sapiens 200-203 24246761-2 2014 We previously showed that the PAH prototype, benzo[a]pyrene (B[a]P), triggers apoptosis via DNA damage-induced p53 activation (genotoxic pathway) and via remodeling of the membrane cholesterol-rich microdomains called lipid rafts, leading to changes in pH homeostasis (non-genotoxic pathway). Benzo(a)pyrene 45-59 tumor protein p53 Homo sapiens 111-114 24798859-5 2015 Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells. Benzo(a)pyrene 50-64 tumor protein p53 Homo sapiens 107-110 24954032-0 2014 PCB153, TCDD and estradiol compromise the benzo[a]pyrene-induced p53-response via FoxO3a. Benzo(a)pyrene 42-56 tumor protein p53 Homo sapiens 65-68 24954032-4 2014 We show that all three compounds amplified the accumulation of nuclear p53, elicited by benzo[a]pyrene (BaP) or dibenzo[al]pyrene (DBP). Benzo(a)pyrene 88-102 tumor protein p53 Homo sapiens 71-74 24954032-4 2014 We show that all three compounds amplified the accumulation of nuclear p53, elicited by benzo[a]pyrene (BaP) or dibenzo[al]pyrene (DBP). Benzo(a)pyrene 104-107 tumor protein p53 Homo sapiens 71-74 24954032-7 2014 We found that inhibition of PP2A phosphatase restored levels of phosphorylated FoxO3a, led to cytosolic translocation of p53, and activated BaP-induced p53-mediated apoptosis. Benzo(a)pyrene 140-143 tumor protein p53 Homo sapiens 152-155 24954032-8 2014 These results were confirmed by silencing FoxO3a with siRNA or by inhibiting 14-3-3 protein; also these treatments trapped BaP-induced p53 in the nucleus. Benzo(a)pyrene 123-126 tumor protein p53 Homo sapiens 135-138 24954032-9 2014 Our data indicate interplay between p53, FoxO3a and 14-3-3 leading to an attenuated BaP induced apoptosis in cells co-exposed to TCDD, PCB 153 or estradiol. Benzo(a)pyrene 84-87 tumor protein p53 Homo sapiens 36-39 24664296-7 2014 Moreover, the level of activated p53 and PARP-1 were significantly induced by BaP, whereas this induction was markedly reduced after curcumin and VE co-treatment. Benzo(a)pyrene 78-81 tumor protein p53 Homo sapiens 33-36 24664296-10 2014 Taken together, BaP-induced cytotoxicity occurs through DNA damage, cell cycle arrest, ROS production, modulation of metabolizing enzymes, and the expression/activation of p53, PARP-1, survivin, and Bax/Bcl-2. Benzo(a)pyrene 16-19 tumor protein p53 Homo sapiens 172-175 24362009-0 2014 Cell cycle changes mediated by the p53/miR-34c axis are involved in the malignant transformation of human bronchial epithelial cells by benzo[a]pyrene. Benzo(a)pyrene 136-150 tumor protein p53 Homo sapiens 35-38 24362009-2 2014 In this investigation, we evaluated changes in p53 function and its downstream target miRNAs in benzo[a]pyrene (BaP)-induced transformation of human bronchial epithelial (HBE) cells. Benzo(a)pyrene 96-110 tumor protein p53 Homo sapiens 47-50 24362009-2 2014 In this investigation, we evaluated changes in p53 function and its downstream target miRNAs in benzo[a]pyrene (BaP)-induced transformation of human bronchial epithelial (HBE) cells. Benzo(a)pyrene 112-115 tumor protein p53 Homo sapiens 47-50 24362009-3 2014 Chronic exposure to BaP induced malignant transformation of cells, in which there were increased levels of mutant p53 (mt-p53) and reduced expression of wild-type p53 (wt-p53) and phosphorylated p53 (p-p53). Benzo(a)pyrene 20-23 tumor protein p53 Homo sapiens 114-117 24362009-3 2014 Chronic exposure to BaP induced malignant transformation of cells, in which there were increased levels of mutant p53 (mt-p53) and reduced expression of wild-type p53 (wt-p53) and phosphorylated p53 (p-p53). Benzo(a)pyrene 20-23 tumor protein p53 Homo sapiens 122-125 24362009-3 2014 Chronic exposure to BaP induced malignant transformation of cells, in which there were increased levels of mutant p53 (mt-p53) and reduced expression of wild-type p53 (wt-p53) and phosphorylated p53 (p-p53). Benzo(a)pyrene 20-23 tumor protein p53 Homo sapiens 122-125 24362009-3 2014 Chronic exposure to BaP induced malignant transformation of cells, in which there were increased levels of mutant p53 (mt-p53) and reduced expression of wild-type p53 (wt-p53) and phosphorylated p53 (p-p53). Benzo(a)pyrene 20-23 tumor protein p53 Homo sapiens 122-125 24362009-3 2014 Chronic exposure to BaP induced malignant transformation of cells, in which there were increased levels of mutant p53 (mt-p53) and reduced expression of wild-type p53 (wt-p53) and phosphorylated p53 (p-p53). Benzo(a)pyrene 20-23 tumor protein p53 Homo sapiens 122-125 24362009-3 2014 Chronic exposure to BaP induced malignant transformation of cells, in which there were increased levels of mutant p53 (mt-p53) and reduced expression of wild-type p53 (wt-p53) and phosphorylated p53 (p-p53). Benzo(a)pyrene 20-23 tumor protein p53 Homo sapiens 122-125 24362009-4 2014 With acute (12h) exposure to BaP, p-p53 was increased, and with increasing time of exposure (24h), the increase in p-p53 at a concentration of 1muM BaP was followed by a decline with increasing concentrations; wt-p53 and mt-p53 did not change. Benzo(a)pyrene 29-32 tumor protein p53 Homo sapiens 36-39 24362009-4 2014 With acute (12h) exposure to BaP, p-p53 was increased, and with increasing time of exposure (24h), the increase in p-p53 at a concentration of 1muM BaP was followed by a decline with increasing concentrations; wt-p53 and mt-p53 did not change. Benzo(a)pyrene 29-32 tumor protein p53 Homo sapiens 117-120 24362009-4 2014 With acute (12h) exposure to BaP, p-p53 was increased, and with increasing time of exposure (24h), the increase in p-p53 at a concentration of 1muM BaP was followed by a decline with increasing concentrations; wt-p53 and mt-p53 did not change. Benzo(a)pyrene 29-32 tumor protein p53 Homo sapiens 117-120 24362009-4 2014 With acute (12h) exposure to BaP, p-p53 was increased, and with increasing time of exposure (24h), the increase in p-p53 at a concentration of 1muM BaP was followed by a decline with increasing concentrations; wt-p53 and mt-p53 did not change. Benzo(a)pyrene 29-32 tumor protein p53 Homo sapiens 117-120 24362009-4 2014 With acute (12h) exposure to BaP, p-p53 was increased, and with increasing time of exposure (24h), the increase in p-p53 at a concentration of 1muM BaP was followed by a decline with increasing concentrations; wt-p53 and mt-p53 did not change. Benzo(a)pyrene 148-151 tumor protein p53 Homo sapiens 117-120 24362009-4 2014 With acute (12h) exposure to BaP, p-p53 was increased, and with increasing time of exposure (24h), the increase in p-p53 at a concentration of 1muM BaP was followed by a decline with increasing concentrations; wt-p53 and mt-p53 did not change. Benzo(a)pyrene 148-151 tumor protein p53 Homo sapiens 117-120 24362009-4 2014 With acute (12h) exposure to BaP, p-p53 was increased, and with increasing time of exposure (24h), the increase in p-p53 at a concentration of 1muM BaP was followed by a decline with increasing concentrations; wt-p53 and mt-p53 did not change. Benzo(a)pyrene 148-151 tumor protein p53 Homo sapiens 117-120 24362009-8 2014 Thus, changes in the cell cycle mediated by the p53/miR-34c axis are involved in the transformation cells induced by BaP. Benzo(a)pyrene 117-120 tumor protein p53 Homo sapiens 48-51 24868967-0 2014 [Roles of p53 in the interaction of p21 and cell cycle proteins induced by benzo [a] pyrene]. Benzo(a)pyrene 75-91 tumor protein p53 Homo sapiens 10-13 24868967-1 2014 OBJECTIVE: To investigate the roles of p53 in the interaction of p21, cyclin D1 and CDK4 in human embryonic lung fibroblasts (HELFs) induced by benzo (a) pyrene. Benzo(a)pyrene 144-160 tumor protein p53 Homo sapiens 39-42 26400171-0 2015 Base damage, local sequence context and TP53 mutation hotspots: a molecular dynamics study of benzo[a]pyrene induced DNA distortion and mutability. Benzo(a)pyrene 94-108 tumor protein p53 Homo sapiens 40-44 26400171-3 2015 Benzo[a]pyrene,diol epoxide (BPDE) is a potent cigarette smoke carcinogen that forms guanine adducts at TP53 CpG mutation hotspot sites including codons 157, 158, 245, 248 and 273. Benzo(a)pyrene 0-14 tumor protein p53 Homo sapiens 104-108 24798859-5 2015 Here, we report that the environmental carcinogen benzo[a]pyrene (BaP) upregulated the expression of seven p53-targeting miRNAs (miR-25, miR-15a, miR-16, miR-92, miR-125b, miR-141, and miR-200a), while 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) upregulated two of them (miR-25 and miR-92) in MM cells. Benzo(a)pyrene 66-69 tumor protein p53 Homo sapiens 107-110 24736433-11 2014 Using p53 heterozygous mutant epithelial cells from patients with Li-Fraumeni syndrome, we show that monoallelic mutation of p53 was associated with elevated levels of CYP1A1 and CYP1B1 under both basal conditions and following treatment with benzo[a]pyrene. Benzo(a)pyrene 243-257 tumor protein p53 Homo sapiens 125-128 24736433-12 2014 Treatment with CP-31398, a p53 rescue compound, suppressed benzo[a]pyrene-mediated induction of CYP1A1 and CYP1B1 and the formation of DNA adducts. Benzo(a)pyrene 59-73 tumor protein p53 Homo sapiens 27-30 24361490-8 2014 Interestingly, the p53 signaling pathway was activated by BaP, but not by TCDD, in BeWo cells and co-treatment by the p53 inhibitor pifithrin-alpha or siRNAs-mediated silencing of p53 prevented up-regulation of beta-hCG and syncytin-2 induced by BaP. Benzo(a)pyrene 58-61 tumor protein p53 Homo sapiens 19-22 24361490-8 2014 Interestingly, the p53 signaling pathway was activated by BaP, but not by TCDD, in BeWo cells and co-treatment by the p53 inhibitor pifithrin-alpha or siRNAs-mediated silencing of p53 prevented up-regulation of beta-hCG and syncytin-2 induced by BaP. Benzo(a)pyrene 58-61 tumor protein p53 Homo sapiens 118-121 24361490-8 2014 Interestingly, the p53 signaling pathway was activated by BaP, but not by TCDD, in BeWo cells and co-treatment by the p53 inhibitor pifithrin-alpha or siRNAs-mediated silencing of p53 prevented up-regulation of beta-hCG and syncytin-2 induced by BaP. Benzo(a)pyrene 58-61 tumor protein p53 Homo sapiens 118-121 24361490-8 2014 Interestingly, the p53 signaling pathway was activated by BaP, but not by TCDD, in BeWo cells and co-treatment by the p53 inhibitor pifithrin-alpha or siRNAs-mediated silencing of p53 prevented up-regulation of beta-hCG and syncytin-2 induced by BaP. Benzo(a)pyrene 246-249 tumor protein p53 Homo sapiens 19-22 24361490-8 2014 Interestingly, the p53 signaling pathway was activated by BaP, but not by TCDD, in BeWo cells and co-treatment by the p53 inhibitor pifithrin-alpha or siRNAs-mediated silencing of p53 prevented up-regulation of beta-hCG and syncytin-2 induced by BaP. Benzo(a)pyrene 246-249 tumor protein p53 Homo sapiens 118-121 24361490-8 2014 Interestingly, the p53 signaling pathway was activated by BaP, but not by TCDD, in BeWo cells and co-treatment by the p53 inhibitor pifithrin-alpha or siRNAs-mediated silencing of p53 prevented up-regulation of beta-hCG and syncytin-2 induced by BaP. Benzo(a)pyrene 246-249 tumor protein p53 Homo sapiens 118-121 24361490-9 2014 Taken together, these data demonstrate that BaP induces differentiation of placental trophoblastic BeWo cells in an AhR- and p53-dependent manner. Benzo(a)pyrene 44-47 tumor protein p53 Homo sapiens 125-128 22410783-7 2013 In comparison, SHD cells immortalized by the powerful polycyclic hydrocarbon carcinogen benzo(a)pyrene display transversion point mutations in the DNA-binding domain of p53 coupled with INK4 alterations such as loss of expression of p15. Benzo(a)pyrene 88-102 tumor protein p53 Homo sapiens 169-172 23703817-1 2013 Benzo(a)pyrene (BaP), a typical environmental carcinogen, can induce cell death both by protein 53 or tumor protein 53 (p53)-independent and -dependent pathways. Benzo(a)pyrene 0-14 tumor protein p53 Homo sapiens 88-98 23703817-1 2013 Benzo(a)pyrene (BaP), a typical environmental carcinogen, can induce cell death both by protein 53 or tumor protein 53 (p53)-independent and -dependent pathways. Benzo(a)pyrene 0-14 tumor protein p53 Homo sapiens 102-118 23703817-1 2013 Benzo(a)pyrene (BaP), a typical environmental carcinogen, can induce cell death both by protein 53 or tumor protein 53 (p53)-independent and -dependent pathways. Benzo(a)pyrene 0-14 tumor protein p53 Homo sapiens 120-123 21887816-6 2013 Pretreatment with cytochrome P450 inhibitor alpha-naphthoflavone or p53 inhibitor pifithrin-alpha inhibited the benzo-[a]-pyrene-induced p21 expression. Benzo(a)pyrene 112-128 tumor protein p53 Homo sapiens 68-71 22227536-8 2012 Our results demonstrated that BaP could induce the malignant transformation of 16HBE cells, and p53 and p-Akt (Ser473) might play crucial roles in BaP-induced carcinogenesis. Benzo(a)pyrene 147-150 tumor protein p53 Homo sapiens 96-99 20862736-1 2012 p53 can mediate DNA damage-induced apoptosis in various cell lines treated with Benzo(a)pyrene (BaP). Benzo(a)pyrene 96-99 tumor protein p53 Homo sapiens 0-3 20862736-2 2012 However, the potential role of p73, one of the p53 family members, in BaP-induced apoptotic cell death remains to be determined. Benzo(a)pyrene 70-73 tumor protein p53 Homo sapiens 47-50 20700368-1 2010 PURPOSE: Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo[a]pyrene, attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 mutations. Benzo(a)pyrene 9-23 tumor protein p53 Homo sapiens 160-163 20840854-7 2010 A dioxin-like PCB (DL-PCB 126) was used as reference and gave results that were predictable from previous studies, i.e. it attenuated BP-induced p53 response and apoptosis. Benzo(a)pyrene 134-136 tumor protein p53 Homo sapiens 145-148 20840854-10 2010 This phosphorylation promotes a cytoplasmic translocation of FoxO3a and p53 and our data suggest that NDL-PCBs may inhibit BP-induced apoptosis by preventing a FoxO3a-dependent translocation of p53 to the cytoplasm. Benzo(a)pyrene 123-125 tumor protein p53 Homo sapiens 72-75 20840854-10 2010 This phosphorylation promotes a cytoplasmic translocation of FoxO3a and p53 and our data suggest that NDL-PCBs may inhibit BP-induced apoptosis by preventing a FoxO3a-dependent translocation of p53 to the cytoplasm. Benzo(a)pyrene 123-125 tumor protein p53 Homo sapiens 194-197 22319594-0 2012 Benzo[a]pyrene, aflatoxine B1 and acetaldehyde mutational patterns in TP53 gene using a functional assay: relevance to human cancer aetiology. Benzo(a)pyrene 0-14 tumor protein p53 Homo sapiens 70-74 22319594-6 2012 By using a functional assay, the Functional Analysis of Separated Alleles in Yeast (FASAY), the present study depicts the mutational pattern of TP53 in normal human fibroblasts after in vitro exposure to well-known carcinogens: benzo[a]pyrene, aflatoxin B(1) and acetaldehyde. Benzo(a)pyrene 228-242 tumor protein p53 Homo sapiens 144-148 22044530-5 2011 TCDD suppressed 1-NP- but not BaP-induced p53 activity, and in contrast, pifithrin-alpha (PFT-alpha), a p53 inhibitor, suppressed both 1-NP- and BaP-induced p53 activity. Benzo(a)pyrene 145-148 tumor protein p53 Homo sapiens 104-107 22044530-5 2011 TCDD suppressed 1-NP- but not BaP-induced p53 activity, and in contrast, pifithrin-alpha (PFT-alpha), a p53 inhibitor, suppressed both 1-NP- and BaP-induced p53 activity. Benzo(a)pyrene 145-148 tumor protein p53 Homo sapiens 104-107 21911080-3 2011 This study focused on mitochondria-mediated cell death and the occurrence of p73 protein accumulation in BaP-treated human hepatoma Hep3B (p53-null) cells. Benzo(a)pyrene 105-108 tumor protein p53 Homo sapiens 139-142 21457773-2 2011 The activation of benzo(a)pyrene (BP), a model compound of polycyclic aromatic hydrocarbons, to its genotoxic BP-diolepoxide (BPDE) and p53 response and cell viability after BP exposure, and the p53 status in these cell lines were analyzed. Benzo(a)pyrene 18-32 tumor protein p53 Homo sapiens 136-139 21457773-2 2011 The activation of benzo(a)pyrene (BP), a model compound of polycyclic aromatic hydrocarbons, to its genotoxic BP-diolepoxide (BPDE) and p53 response and cell viability after BP exposure, and the p53 status in these cell lines were analyzed. Benzo(a)pyrene 18-32 tumor protein p53 Homo sapiens 195-198 21457773-2 2011 The activation of benzo(a)pyrene (BP), a model compound of polycyclic aromatic hydrocarbons, to its genotoxic BP-diolepoxide (BPDE) and p53 response and cell viability after BP exposure, and the p53 status in these cell lines were analyzed. Benzo(a)pyrene 34-36 tumor protein p53 Homo sapiens 136-139 21457773-2 2011 The activation of benzo(a)pyrene (BP), a model compound of polycyclic aromatic hydrocarbons, to its genotoxic BP-diolepoxide (BPDE) and p53 response and cell viability after BP exposure, and the p53 status in these cell lines were analyzed. Benzo(a)pyrene 34-36 tumor protein p53 Homo sapiens 195-198 21457773-5 2011 After BP-treatment the strongest p53 protein induction and phosphorylation at serine 392 was found in ZR-75-1 cells with a wt TP53 gene. Benzo(a)pyrene 6-8 tumor protein p53 Homo sapiens 33-36 21457773-5 2011 After BP-treatment the strongest p53 protein induction and phosphorylation at serine 392 was found in ZR-75-1 cells with a wt TP53 gene. Benzo(a)pyrene 6-8 tumor protein p53 Homo sapiens 126-130 20840854-3 2010 We have evaluated the effects of some highly purified NDL-PCBs and benzo[a]pyrene (BP) on BP-induced Raf, Erk, Mdm2, p53 signaling and on BP-induced apoptosis and cell cycle arrest. Benzo(a)pyrene 83-85 tumor protein p53 Homo sapiens 117-120 20596254-2 2010 BaP 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo(a)pyrene (BaP), attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 gene mutations. Benzo(a)pyrene 0-3 tumor protein p53 Homo sapiens 146-149 20596254-2 2010 BaP 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo(a)pyrene (BaP), attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 gene mutations. Benzo(a)pyrene 60-74 tumor protein p53 Homo sapiens 146-149 20596254-2 2010 BaP 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo(a)pyrene (BaP), attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 gene mutations. Benzo(a)pyrene 76-79 tumor protein p53 Homo sapiens 146-149 20700368-1 2010 PURPOSE: Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo[a]pyrene, attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 mutations. Benzo(a)pyrene 80-94 tumor protein p53 Homo sapiens 160-163 20371965-6 2010 Moreover, it was shown that cotreatment with MDA-LDL and BaP markedly induced the expression of human cytochrome P4501A1 (hCYP1A1) messenger ribonucleic acid (mRNA) and significantly induced the expressions of p53 and p21 mRNAs. Benzo(a)pyrene 57-60 tumor protein p53 Homo sapiens 210-213 18440733-0 2008 Benzo(a)pyrene increases phosphorylation of p53 at serine 392 in relation to p53 induction and cell death in MCF-7 cells. Benzo(a)pyrene 0-14 tumor protein p53 Homo sapiens 44-47 19397966-1 2009 Benzo(a)pyrene (BP) forms benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE)-DNA adducts in human breast adenocarcinoma MCF-7 cells, leading to p53 protein induction and phosphorylation. Benzo(a)pyrene 0-14 tumor protein p53 Homo sapiens 144-147 19397966-1 2009 Benzo(a)pyrene (BP) forms benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE)-DNA adducts in human breast adenocarcinoma MCF-7 cells, leading to p53 protein induction and phosphorylation. Benzo(a)pyrene 16-18 tumor protein p53 Homo sapiens 144-147 19397966-3 2009 Here we have analyzed the effects of BP on p53 related apoptotic proteins, cell cycle and cell death in MCF-7 cells. Benzo(a)pyrene 37-39 tumor protein p53 Homo sapiens 43-46 19397966-4 2009 PUMA-protein (p53 up-regulated modulator of apoptosis) levels were changed after BP exposure so that PUMA-alpha protein was statistically significantly increased whereas PUMA-beta protein was statistically significantly decreased. Benzo(a)pyrene 81-83 tumor protein p53 Homo sapiens 14-17 19397966-9 2009 Our results suggest that PUMA-alpha protein is involved in BP-induced cell death most likely through a p53 dependent apoptotic pathway. Benzo(a)pyrene 59-61 tumor protein p53 Homo sapiens 103-106 19027820-0 2009 Cyclin A is essential for the p53-modulated inhibition from benzo(a)pyrene toxicity in A549 cells. Benzo(a)pyrene 60-74 tumor protein p53 Homo sapiens 30-33 19027820-8 2009 These results indicated that cyclin A is regulated by p53, not by B(a)P, and it is essential in the p53-modulated inhibition from benzo(a)pyrene toxicity in A549 cells, cyclin E and p21 also as downstream genes of p53 involved it, which is p27-independent. Benzo(a)pyrene 130-144 tumor protein p53 Homo sapiens 100-103 19027820-8 2009 These results indicated that cyclin A is regulated by p53, not by B(a)P, and it is essential in the p53-modulated inhibition from benzo(a)pyrene toxicity in A549 cells, cyclin E and p21 also as downstream genes of p53 involved it, which is p27-independent. Benzo(a)pyrene 130-144 tumor protein p53 Homo sapiens 100-103 18788085-1 2008 Benzo[a]pyrene diol epoxide (B[a]PDE), the ultimate carcinogenic metabolite of benzo[a] pyrene, has been implicated in the mutagenesis of the p53 gene involved in smoking-associated lung cancer. Benzo(a)pyrene 79-94 tumor protein p53 Homo sapiens 142-145 19035040-1 2008 OBJECTIVE: To investigate the roles of p53 in cell cycle changes on human embryo lung fibroblasts (HELF) induced by benzo(a) pyrene[ B(a) P], and relationships between p53 and p21, E2F-1. Benzo(a)pyrene 116-131 tumor protein p53 Homo sapiens 39-42 18448277-0 2008 Benzo(a)pyrene-caused increased G1-S transition requires the activation of c-Jun through p53-dependent PI-3K/Akt/ERK pathway in human embryo lung fibroblasts. Benzo(a)pyrene 0-14 tumor protein p53 Homo sapiens 89-92 18440733-0 2008 Benzo(a)pyrene increases phosphorylation of p53 at serine 392 in relation to p53 induction and cell death in MCF-7 cells. Benzo(a)pyrene 0-14 tumor protein p53 Homo sapiens 77-80 18440733-10 2008 These results suggest that serine 392 phosphorylation is the first stabilizing event of p53 associated with BP exposure and subsequent cell death in MCF-7 cells. Benzo(a)pyrene 108-110 tumor protein p53 Homo sapiens 88-91 18406507-0 2008 MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: involvement of p53 phosphorylation and acetylation. Benzo(a)pyrene 50-64 tumor protein p53 Homo sapiens 14-17 18406507-0 2008 MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: involvement of p53 phosphorylation and acetylation. Benzo(a)pyrene 50-64 tumor protein p53 Homo sapiens 81-84 17942461-7 2008 Interestingly, DNA adduct formation after BaP, but not BPDE, exposure was p53 dependent with 10-fold lower levels detected in p53-null cells. Benzo(a)pyrene 42-45 tumor protein p53 Homo sapiens 74-77 18646516-0 2008 [Overexpression and higher phosphorylation of p53 induced by benzo(a) pyrene through activated protein 1 independent pathway]. Benzo(a)pyrene 61-76 tumor protein p53 Homo sapiens 46-49 18646516-1 2008 OBJECTIVE: To investigate changes of p53 expression, p53 phosphorylation, and their subcellular localizations and activated protein 1 (AP-1) activity on human embryo lung fibroblasts (HELF) induced by benzo(a)pyrene (B(a)P), and relationships between p53 and AP-1. Benzo(a)pyrene 201-215 tumor protein p53 Homo sapiens 37-40 17998932-6 2008 In cell lines ensuing from benzo(a)pyrene-treated cultures the combined p53 mutation pattern from experiments with the 3 codon 72 genotypes showed a predominance of strand-biased G to T transversions (18 of 36 mutations), and mutations recurring at smokers" lung tumour hotspot codons 157 and 273, supporting involvement of tobacco carcinogens in shaping the mutation signature in lung cancers of smokers. Benzo(a)pyrene 27-41 tumor protein p53 Homo sapiens 72-75 18096571-7 2008 The more mutagenic dibenzo[a,l]pyrene as well as higher BP concentrations instead induced gammaH2AX and p53 Ser15 association with chromatin. Benzo(a)pyrene 56-58 tumor protein p53 Homo sapiens 104-107 18096571-8 2008 Acrolein potentiated the effect of BP on p53 stabilization and chromatin binding. Benzo(a)pyrene 35-37 tumor protein p53 Homo sapiens 41-44 17942461-0 2008 Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53. Benzo(a)pyrene 84-98 tumor protein p53 Homo sapiens 157-160 17932951-0 2008 Anti-diol epoxide of benzo[a]pyrene induces transient Mdm2 and p53 Ser15 phosphorylation, while anti-diol epoxide of dibenzo[a,l]pyrene induces a nontransient p53 Ser15 phosphorylation. Benzo(a)pyrene 21-35 tumor protein p53 Homo sapiens 63-66 17942461-7 2008 Interestingly, DNA adduct formation after BaP, but not BPDE, exposure was p53 dependent with 10-fold lower levels detected in p53-null cells. Benzo(a)pyrene 42-45 tumor protein p53 Homo sapiens 126-129 17942461-8 2008 Other cell lines were investigated for BaP-DNA adduct formation and in these the effect of p53 knockdown was also to reduce adduct formation. Benzo(a)pyrene 39-42 tumor protein p53 Homo sapiens 91-94 17942461-9 2008 Taken together, these results give further insight into the role of p53 in the response of human cells to BaP and BPDE and suggest that loss of this tumour suppressor can influence the metabolic activation of BaP. Benzo(a)pyrene 106-109 tumor protein p53 Homo sapiens 68-71 17942461-9 2008 Taken together, these results give further insight into the role of p53 in the response of human cells to BaP and BPDE and suggest that loss of this tumour suppressor can influence the metabolic activation of BaP. Benzo(a)pyrene 209-212 tumor protein p53 Homo sapiens 68-71 17678638-8 2007 By contrast to numerous DNA damaging agents such as BaP which is known to stimulate p53 expression, the lack of p53 response by 6-NC imply the lack of protective functions mediated by p53 (e.g. DNA repair machinery) after exposure to 6-NC and this may, in part, account for its remarkable carcinogenicity in the mammary tissue. Benzo(a)pyrene 52-55 tumor protein p53 Homo sapiens 84-87 16926039-7 2006 Furthermore, BaP increased p53 levels in both p53 positive cell lines, as well as p21 levels in MCF-7 cells, an effect that was prevented by the p53-specific inhibitor pifithrin-alpha. Benzo(a)pyrene 13-16 tumor protein p53 Homo sapiens 27-30 17029827-4 2006 The response of phosphorylated p53 may be more sensitive towards benzo[a]pyrene exposure than normal p53. Benzo(a)pyrene 65-79 tumor protein p53 Homo sapiens 31-34 16926039-7 2006 Furthermore, BaP increased p53 levels in both p53 positive cell lines, as well as p21 levels in MCF-7 cells, an effect that was prevented by the p53-specific inhibitor pifithrin-alpha. Benzo(a)pyrene 13-16 tumor protein p53 Homo sapiens 46-49 17029827-5 2006 Following DNA damage, the activation of p53 acts as a transcriptional regulator of several target genes, including, p21 protein; a gene that encodes the Cdk inhibitor and is induced by exposure to benzo[a]pyrene. Benzo(a)pyrene 197-211 tumor protein p53 Homo sapiens 40-43 17029827-6 2006 The p53 mRNA level was increased after the treatment of cells with benzo[a]pyrene, as well as following the induction of p53 protein, suggesting the benzo[a]pyrene-stimulated p53 accumulation may also be transcriptionally induced. Benzo(a)pyrene 67-81 tumor protein p53 Homo sapiens 4-7 17029827-6 2006 The p53 mRNA level was increased after the treatment of cells with benzo[a]pyrene, as well as following the induction of p53 protein, suggesting the benzo[a]pyrene-stimulated p53 accumulation may also be transcriptionally induced. Benzo(a)pyrene 149-163 tumor protein p53 Homo sapiens 4-7 17029827-6 2006 The p53 mRNA level was increased after the treatment of cells with benzo[a]pyrene, as well as following the induction of p53 protein, suggesting the benzo[a]pyrene-stimulated p53 accumulation may also be transcriptionally induced. Benzo(a)pyrene 149-163 tumor protein p53 Homo sapiens 121-124 17029827-6 2006 The p53 mRNA level was increased after the treatment of cells with benzo[a]pyrene, as well as following the induction of p53 protein, suggesting the benzo[a]pyrene-stimulated p53 accumulation may also be transcriptionally induced. Benzo(a)pyrene 149-163 tumor protein p53 Homo sapiens 121-124 17029827-7 2006 The overall results suggest that benzo[a]pyrene leads to serious DNA damage, which leads to the transcription of the p53 gene; that the subsequent p53 protein accumulation up-regulates the cellular p21 protein. Benzo(a)pyrene 33-47 tumor protein p53 Homo sapiens 117-120 16926039-7 2006 Furthermore, BaP increased p53 levels in both p53 positive cell lines, as well as p21 levels in MCF-7 cells, an effect that was prevented by the p53-specific inhibitor pifithrin-alpha. Benzo(a)pyrene 13-16 tumor protein p53 Homo sapiens 46-49 15805253-5 2005 With the Hupki assay we examined here whether benzo(a)pyrene (BaP), a major tobacco smoke carcinogen could elicit p53 mutation patterns characterizing the human lung tumor p53 mutation spectrum. Benzo(a)pyrene 46-60 tumor protein p53 Homo sapiens 114-117 17029827-7 2006 The overall results suggest that benzo[a]pyrene leads to serious DNA damage, which leads to the transcription of the p53 gene; that the subsequent p53 protein accumulation up-regulates the cellular p21 protein. Benzo(a)pyrene 33-47 tumor protein p53 Homo sapiens 147-150 17029827-8 2006 Oxidative DNA damage and p53 accumulation seem to be related to benzo[a]pyrene toxicity; however, their potential as biomarkers in environmental monitoring and risk assessment needs to be validated in the context of their specificity and sensitivity. Benzo(a)pyrene 64-78 tumor protein p53 Homo sapiens 25-28 16297369-0 2005 p38 MAP kinase regulates benzo(a)pyrene-induced apoptosis through the regulation of p53 activation. Benzo(a)pyrene 25-39 tumor protein p53 Homo sapiens 84-87 16297369-5 2005 Also, pharmacological inhibition of p38 markedly inhibited the phosphorylation, accumulated expression, and transactivation activity of p53 in BaP-treated cells. Benzo(a)pyrene 143-146 tumor protein p53 Homo sapiens 136-139 16297369-7 2005 Furthermore, p53 mediated apoptotic activity in BaP-treated cells was inhibited by p38 kinase inhibitor. Benzo(a)pyrene 48-51 tumor protein p53 Homo sapiens 13-16 17026772-11 2006 The clinical behavior, the high recurrence rate and the even higher malignant transformation occurrence, as well as the presence of carcinogenetic indicators (K-ras mutation, overexpression of p53, MUC and Tn antigens) strongly support that BP is a low-grade neoplasm with high malignant potential. Benzo(a)pyrene 241-243 tumor protein p53 Homo sapiens 193-196 15837074-0 2005 Benzo[a]pyrene, but not 2,3,7,8-TCDD, induces G2/M cell cycle arrest, p21CIP1 and p53 phosphorylation in human choriocarcinoma JEG-3 cells: a distinct signaling pathway. Benzo(a)pyrene 0-14 tumor protein p53 Homo sapiens 82-85 15625077-8 2005 Thus, in HepG2 cells pravastatin and simvastatin pretreatment attenuated the p53 response to DNA damage induced by 5-fluorouracil and benzo(a)pyrene. Benzo(a)pyrene 134-148 tumor protein p53 Homo sapiens 77-80 15805253-5 2005 With the Hupki assay we examined here whether benzo(a)pyrene (BaP), a major tobacco smoke carcinogen could elicit p53 mutation patterns characterizing the human lung tumor p53 mutation spectrum. Benzo(a)pyrene 46-60 tumor protein p53 Homo sapiens 172-175 15705463-2 2005 Research published in 1996 by Denissenko and colleagues demonstrated patterned in-vitro mutagenic effects on p53 of benzo[a]pyrene, a carcinogen present in tobacco smoke. Benzo(a)pyrene 116-130 tumor protein p53 Homo sapiens 109-112 15595848-1 2004 Codon 273 ((5)(")CGT) of the human P53 gene is a mutational hot spot for the environmental carcinogen benzo[a]pyrene. Benzo(a)pyrene 102-116 tumor protein p53 Homo sapiens 35-38 12807757-3 2003 The current study examines the ability of acrolein to modulate the effect of benzo[a]pyrene (B[a]P), a major carcinogen found in smoke, on p53. Benzo(a)pyrene 77-91 tumor protein p53 Homo sapiens 139-142 15072824-8 2004 The high formation of BPDE-N(2)-dG adducts in bronchial epithelial cells and investigations showing that the profile of mutations induced by BPDE in these cells is similar to that seen in the p53 gene isolated from human lung tumors implicates benzo[a]pyrene as important carcinogen in tobacco-induced lung cancer in human beings. Benzo(a)pyrene 244-258 tumor protein p53 Homo sapiens 192-195 14644313-10 2003 Thus, for benzo(a)pyrene (at 10-50 adducts per 10(8) nucleotides) repair was essentially complete within 1 day in p53(+/+) human fibroblasts while no repair was detected within 3 days in p53(-/-) cells. Benzo(a)pyrene 10-24 tumor protein p53 Homo sapiens 114-117 14644313-10 2003 Thus, for benzo(a)pyrene (at 10-50 adducts per 10(8) nucleotides) repair was essentially complete within 1 day in p53(+/+) human fibroblasts while no repair was detected within 3 days in p53(-/-) cells. Benzo(a)pyrene 10-24 tumor protein p53 Homo sapiens 187-190 15081398-3 2004 BP-treatment was found to dramatically alter their functional capacities and to trigger a caspase- and mitochondrion-related apoptosis, associated with down-regulation of the survival factors c-FLIP(L) and Bcl-X(L) and up-regulation of the pro-apoptotic factor p53. Benzo(a)pyrene 0-2 tumor protein p53 Homo sapiens 261-264 12507920-8 2002 These results are also consistent with the hypothesis that BP (PAH) induce G:C to T:A transversion mutations in the hotspot codons of the p53 tumor suppressor gene and are thus involved in malignant transformation of the lung tissue of smokers. Benzo(a)pyrene 59-61 tumor protein p53 Homo sapiens 138-141 12807757-0 2003 Modulation of benzo[a]pyrene-induced p53 DNA activity by acrolein. Benzo(a)pyrene 14-28 tumor protein p53 Homo sapiens 37-40 12538356-4 2003 Ultraviolet (UV) light from the sun and polycyclic aromatic hydrocarbons, such as benzo[a]pyrene, are strongly implicated in the spectrum of p53 mutations found in human non-melanoma skin cancers and smoking-associated lung cancers, respectively. Benzo(a)pyrene 82-96 tumor protein p53 Homo sapiens 141-144 10708967-0 2000 Mutagenicity of benzo[a]pyrene-deoxyadenosine adducts in a sequence context derived from the p53 gene. Benzo(a)pyrene 16-30 tumor protein p53 Homo sapiens 93-96 11522624-3 2001 In the present study, we have used a highly sensitive mutation assay to determine the p53 mutation load in nontumorous human lung and to study the mutability of p53 codons 157, 248, 249, and 250 to benzo(a)pyrene-diol-epoxide (BPDE), an active metabolite of BP in human bronchial epithelial BEAS-2B cells. Benzo(a)pyrene 227-229 tumor protein p53 Homo sapiens 161-164 11522624-13 2001 These data are consistent with the hypothesis that chemical carcinogens such as BP in cigarette smoke cause G:C to T:A transversions at p53 codons 157, 248, and 249 and that nontumorous lung tissues from smokers with lung cancer carry a high p53 mutational load at these codons. Benzo(a)pyrene 80-82 tumor protein p53 Homo sapiens 136-139 11522624-13 2001 These data are consistent with the hypothesis that chemical carcinogens such as BP in cigarette smoke cause G:C to T:A transversions at p53 codons 157, 248, and 249 and that nontumorous lung tissues from smokers with lung cancer carry a high p53 mutational load at these codons. Benzo(a)pyrene 80-82 tumor protein p53 Homo sapiens 242-245 11191113-0 2000 Disruption of cell cycle kinetics by benzo[a]pyrene: inverse expression patterns of BRCA-1 and p53 in MCF-7 cells arrested in S and G2. Benzo(a)pyrene 37-51 tumor protein p53 Homo sapiens 95-98 10837373-3 2000 In the present study, the induction of p53 target gene expression after the treatment with either benzo(a)pyrene (B[a]P) or 1-nitropyrene (1-NP) was investigated. Benzo(a)pyrene 98-112 tumor protein p53 Homo sapiens 39-42 10708967-2 2000 Recent research has shown that tobacco-associated cancer in the human lung is related to mutation of the p53 gene mediated by the carcinogen benzo[a]pyrene (BaP), and the mutations are targeted to DNA "hot spots" at specific codons. Benzo(a)pyrene 141-155 tumor protein p53 Homo sapiens 105-108 10708967-2 2000 Recent research has shown that tobacco-associated cancer in the human lung is related to mutation of the p53 gene mediated by the carcinogen benzo[a]pyrene (BaP), and the mutations are targeted to DNA "hot spots" at specific codons. Benzo(a)pyrene 157-160 tumor protein p53 Homo sapiens 105-108 14646501-1 1998 A number of genotoxic chemicals and agents, such as benzo(a)pyrene and ultraviolet light, are able to induce nuclear accumulation of p53 protein. Benzo(a)pyrene 52-66 tumor protein p53 Homo sapiens 133-136 10575010-0 1999 Benzo[a]pyrene activates the human p53 gene through induction of nuclear factor kappaB activity. Benzo(a)pyrene 0-14 tumor protein p53 Homo sapiens 35-38 10575010-2 1999 In the present study, the effect of a potent lung cancer carcinogen, benzo[a]pyrene (B[a]P) on p53 expression was investigated. Benzo(a)pyrene 69-83 tumor protein p53 Homo sapiens 95-98 9920731-4 1999 The topical application of 50 microg/cm2 BaP to EpiDerm resulted in the accumulation of BaP-DNA adducts and c-fos and p53 proteins as evidenced by immunohistochemical localization. Benzo(a)pyrene 41-44 tumor protein p53 Homo sapiens 118-121 9468547-14 1998 Thus, BP-induced aberrant proliferation is inhibited by the natural phytochemicals in part due to regulation of cell cycle progression and induction of p53 dependent apoptosis. Benzo(a)pyrene 6-8 tumor protein p53 Homo sapiens 152-155 9855010-9 1998 There was also a significant correlation between serum p53 protein levels and the cumulated benzo[a]pyrene exposure dose. Benzo(a)pyrene 92-106 tumor protein p53 Homo sapiens 55-58 9472715-4 1998 Immunohistochemical detection of p53 protein showed positive cells in human skin after UV-irradiation, in mouse skin after benzo[a]pyrene treatment and in mouse spleen, thymus and bone after gamma-irradiation. Benzo(a)pyrene 123-137 tumor protein p53 Homo sapiens 33-36 8036011-7 1994 It is evident that H2O2/FeCl3 possesses essentially the same mutagenic specificity for codons 249 and 250 of p53 as bulky carcinogens such as aflatoxin B1, benzo(a)pyrene or heterocyclic amines. Benzo(a)pyrene 156-170 tumor protein p53 Homo sapiens 109-112 7554063-0 1995 p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines. Benzo(a)pyrene 42-56 tumor protein p53 Homo sapiens 0-3 7554063-2 1995 We have measured benzo[a]pyrene (BP)-induced DNA damage in association with p53 expression. Benzo(a)pyrene 17-31 tumor protein p53 Homo sapiens 76-79 7554063-2 1995 We have measured benzo[a]pyrene (BP)-induced DNA damage in association with p53 expression. Benzo(a)pyrene 33-35 tumor protein p53 Homo sapiens 76-79 7554063-4 1995 Activation of BP in A-549 lung carcinoma and MCF-7 breast adenocarcinoma cell lines containing wild-type p53 was followed by an increase in p53 protein expression. Benzo(a)pyrene 14-16 tumor protein p53 Homo sapiens 105-108 7554063-4 1995 Activation of BP in A-549 lung carcinoma and MCF-7 breast adenocarcinoma cell lines containing wild-type p53 was followed by an increase in p53 protein expression. Benzo(a)pyrene 14-16 tumor protein p53 Homo sapiens 140-143 7554063-8 1995 These findings indicate that p53 protein is part of the response of the cells to BP-induced DNA damage. Benzo(a)pyrene 81-83 tumor protein p53 Homo sapiens 29-32 7766306-6 1995 The other two benzo[a]pyrene-induced base-pair changes in codon 248, namely the C-to-A transversion in the first position and G-to-T transversion in the third position, do not lead to a change in the amino-acid composition of the p53 protein. Benzo(a)pyrene 14-28 tumor protein p53 Homo sapiens 230-233 7766306-8 1995 It follows that benzo[a]pyrene-induced mutability on the DNA level in p53 codons 247-250 correlates well with the type of mutation found in tumors of the lung. Benzo(a)pyrene 16-30 tumor protein p53 Homo sapiens 70-73 8832894-0 1996 Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53. Benzo(a)pyrene 26-40 tumor protein p53 Homo sapiens 87-90 8895489-1 1996 Human lung cancer exhibits a high frequency of transversion mutations at G:C base pairs of the p53 gene, possibly the result of DNA damage by cigarette smoke constituents, most notably benzo[a]pyrene. Benzo(a)pyrene 185-199 tumor protein p53 Homo sapiens 95-98 34610339-0 2021 Malignant transformation of human bronchial epithelial cells induced by benzo (a) pyrene suggests a negative feedback of TP53 to PPP1R13L via binding a possible enhancer element. Benzo(a)pyrene 72-88 tumor protein p53 Homo sapiens 121-125 1933877-4 1991 Thirteen of 14 nucleotide residues of the p53 gene which underwent G:C to T:A mutations in lung cancers were targeted by benzo(a)pyrene. Benzo(a)pyrene 121-135 tumor protein p53 Homo sapiens 42-45 34690024-8 2021 BaP-conditioned medium significantly increased DNA damage, p53 stabilization, AhR activation and POMC secretion in keratinocytes. Benzo(a)pyrene 0-3 tumor protein p53 Homo sapiens 59-62 32588678-6 2020 Cells exposed to BaP showed prominent changes in the expression of mitochondrial microRNAs (miR-24, miR-34a, miR-150, and miR-155) and their respective gene targets (NF-kappabeta, MYC, and p53). Benzo(a)pyrene 17-20 tumor protein p53 Homo sapiens 189-192 28374118-1 2018 In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0. Benzo(a)pyrene 87-101 tumor protein p53 Homo sapiens 204-207 28374118-1 2018 In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock Tools 4.0. Benzo(a)pyrene 79-81 tumor protein p53 Homo sapiens 204-207 28374118-4 2018 Diol-epoxides of DBP and BP were found to bind to p53 with tighter interaction than MDM2 and p53-MDM2 complex. Benzo(a)pyrene 18-20 tumor protein p53 Homo sapiens 50-53 28374118-4 2018 Diol-epoxides of DBP and BP were found to bind to p53 with tighter interaction than MDM2 and p53-MDM2 complex. Benzo(a)pyrene 18-20 tumor protein p53 Homo sapiens 93-96 29471073-1 2018 Polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) can induce cytochrome P450 1A1 (CYP1A1) via a p53-dependent mechanism. Benzo(a)pyrene 41-55 tumor protein p53 Homo sapiens 108-111