PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35315151-11 2022 When exposed to pollution stress by treating the models with benzo(a)pyrene and airborne particulate matter (PM10), application of both formulations prior to exposure attenuated the induction of CYP1A1, CYP1B1 and UGT1A7 expression, indicating a protective effect. Benzo(a)pyrene 61-75 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 195-201 35065163-7 2022 The highest amount of COX-2, the most increased activity of CYP1A1 and cPLA2, and overexpression of GSTM1, CYP1A1, ICAM-1, and VCAM-1 gene was observed in HUVEC cells treated with BaP. Benzo(a)pyrene 180-183 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 107-113 35065163-9 2022 Incubation of endothelial cells with ARA or EPA and BaP resulted in lower CYP1A1 and cPLA2 activities and lower expression of VCAM-1 and ICAM-1 genes. Benzo(a)pyrene 52-55 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 74-80 2512389-9 1989 This study is a clear indication of the major role of P-450IA1 (P-450c) in human placenta and probably P-450IA2 (P-450d) in human liver in BP activation, while other isozymes also take part in the activation in rat liver. Benzo(a)pyrene 139-141 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 64-71 35193440-0 2022 Alterations of DNA methylation and mRNA levels of CYP1A1, GSTP1, and GSTM1 in human bronchial epithelial cells induced by benzo(a)pyrene. Benzo(a)pyrene 122-136 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 50-56 35193440-6 2022 The mRNA levels of CYP1A1, GSTP1, and GSTM1 were significantly decreased in 16HBEs following B(a)P treatment at all three doses. Benzo(a)pyrene 93-98 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 19-25 32730838-6 2020 3-Methylcholanthrene (3-MC), benz[a]anthracene (B[a]A), benzo[a]pyrene (B[a]P), and valproic acid (VPA) increased the expression of CYP1B1 and CYP1A1. Benzo(a)pyrene 56-70 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 143-149 2989797-0 1985 Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism. Benzo(a)pyrene 79-93 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 6-12 33227946-9 2020 In summary, Thalassia testudinum metabolites exhibit antigenotoxic activity mediated, at least, by the inhibition of CYP1A1-mediated BP biotransformation, arresting the oxidative and mutagenic damage. Benzo(a)pyrene 133-135 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 117-123 33991922-4 2021 In this study, complexes of BaP with CYP1A1, CYP1B1 or CYP2C19 compound I were successfully simulated by QM/MM methods and verified by metabolic clearance, and the mutagenicity of chemicals was then predicted by the BaP-7,8-epoxide-related metabolic conformation fitness (MCF) approach, which was validated by Ames tests, showing satisfying accuracy (R2 = 0.46-0.66). Benzo(a)pyrene 28-31 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 37-43 33411230-9 2021 The phase I biotransformation enzymes, CYP1A1 and 1B1, showed BaP concentration-dependent expression. Benzo(a)pyrene 62-65 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 39-53 32349929-3 2020 Benzo[a]pyrene (BaP) was activated by endogenous cytochrome P450 (cytochrome P450 family 1 subfamily A member 1 [CYP1A1]) to create genomically modified NHU cells. Benzo(a)pyrene 0-14 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 66-111 32349929-3 2020 Benzo[a]pyrene (BaP) was activated by endogenous cytochrome P450 (cytochrome P450 family 1 subfamily A member 1 [CYP1A1]) to create genomically modified NHU cells. Benzo(a)pyrene 0-14 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 113-119 32349929-3 2020 Benzo[a]pyrene (BaP) was activated by endogenous cytochrome P450 (cytochrome P450 family 1 subfamily A member 1 [CYP1A1]) to create genomically modified NHU cells. Benzo(a)pyrene 16-19 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 66-111 32349929-3 2020 Benzo[a]pyrene (BaP) was activated by endogenous cytochrome P450 (cytochrome P450 family 1 subfamily A member 1 [CYP1A1]) to create genomically modified NHU cells. Benzo(a)pyrene 16-19 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 113-119 30572064-8 2019 The downregulation and/or inhibition of CYP1 enzymes by PUFAs could thus alter metabolism and reduce genotoxicity of BaP in human colon cells, which might contribute to known chemopreventive effects of PUFAs in colon epithelium. Benzo(a)pyrene 117-120 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 40-44 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Benzo(a)pyrene 115-129 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Benzo(a)pyrene 115-129 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 31730885-5 2020 In present study, we used benzo[a]pyrene (BaP), a classic and potent ligand of AhR, to activate AhR pathway causes overexpression of the estrogen-metabolizing enzyme cytochrome P450 1A1 (CYP1A1) and affects the expression of important genes involved in hepatic lipid regulation. Benzo(a)pyrene 26-40 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 166-185 31730885-5 2020 In present study, we used benzo[a]pyrene (BaP), a classic and potent ligand of AhR, to activate AhR pathway causes overexpression of the estrogen-metabolizing enzyme cytochrome P450 1A1 (CYP1A1) and affects the expression of important genes involved in hepatic lipid regulation. Benzo(a)pyrene 26-40 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 187-193 31730885-5 2020 In present study, we used benzo[a]pyrene (BaP), a classic and potent ligand of AhR, to activate AhR pathway causes overexpression of the estrogen-metabolizing enzyme cytochrome P450 1A1 (CYP1A1) and affects the expression of important genes involved in hepatic lipid regulation. Benzo(a)pyrene 42-45 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 166-185 31730885-5 2020 In present study, we used benzo[a]pyrene (BaP), a classic and potent ligand of AhR, to activate AhR pathway causes overexpression of the estrogen-metabolizing enzyme cytochrome P450 1A1 (CYP1A1) and affects the expression of important genes involved in hepatic lipid regulation. Benzo(a)pyrene 42-45 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 187-193 31730885-6 2020 BaP induces CYP1A1 expression through AhR signaling and inhibits the protective effect of 17beta-estradiol (E2) on hepatic steatosis, characterized by triglyceride accumulation, and markers of liver damage are significantly elevated. Benzo(a)pyrene 0-3 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 12-18 30862515-1 2019 Benzo[alpha]Pyrene (B[a]P) causes toxicity via Cytochrome P450 1A1 (CYP1A1) metabolic activity in the brain. Benzo(a)pyrene 20-25 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 47-66 30862515-1 2019 Benzo[alpha]Pyrene (B[a]P) causes toxicity via Cytochrome P450 1A1 (CYP1A1) metabolic activity in the brain. Benzo(a)pyrene 20-25 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 68-74 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Benzo(a)pyrene 131-136 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Benzo(a)pyrene 131-136 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 32526964-1 2020 Benzo[a]pyrene (BaP), a major environmental pollutant, activates aryl hydrocarbon receptor (AHR), induces its cytoplasmic-to-nuclear translocation and upregulates the production of cytochrome P450 1A1 (CYP1A1), a xenobiotic metabolizing enzyme which metabolize BaP. Benzo(a)pyrene 0-14 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 181-200 32526964-1 2020 Benzo[a]pyrene (BaP), a major environmental pollutant, activates aryl hydrocarbon receptor (AHR), induces its cytoplasmic-to-nuclear translocation and upregulates the production of cytochrome P450 1A1 (CYP1A1), a xenobiotic metabolizing enzyme which metabolize BaP. Benzo(a)pyrene 0-14 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 202-208 32526964-1 2020 Benzo[a]pyrene (BaP), a major environmental pollutant, activates aryl hydrocarbon receptor (AHR), induces its cytoplasmic-to-nuclear translocation and upregulates the production of cytochrome P450 1A1 (CYP1A1), a xenobiotic metabolizing enzyme which metabolize BaP. Benzo(a)pyrene 16-19 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 181-200 32526964-1 2020 Benzo[a]pyrene (BaP), a major environmental pollutant, activates aryl hydrocarbon receptor (AHR), induces its cytoplasmic-to-nuclear translocation and upregulates the production of cytochrome P450 1A1 (CYP1A1), a xenobiotic metabolizing enzyme which metabolize BaP. Benzo(a)pyrene 16-19 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 202-208 32526964-1 2020 Benzo[a]pyrene (BaP), a major environmental pollutant, activates aryl hydrocarbon receptor (AHR), induces its cytoplasmic-to-nuclear translocation and upregulates the production of cytochrome P450 1A1 (CYP1A1), a xenobiotic metabolizing enzyme which metabolize BaP. Benzo(a)pyrene 261-264 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 181-200 32526964-5 2020 BAI and BAI-containing herbal medicine Wogon and Oren-gedoku-to could inhibit the BaP-induced CYP1A1 expression. Benzo(a)pyrene 82-85 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 94-100 32526964-9 2020 These results indicate that BAI and BAI-containing herbal drugs may be useful for inhibiting the toxic effects of BaP via dual AHR-CYP1A1-inhibiting and NRF2-HMOX1-activating activities. Benzo(a)pyrene 114-117 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 131-137 31112310-4 2020 First, 1-methylpyrene, 1-hydroxymethylpyrene, benzo[a]pyrene, and aflatoxin B1 significantly induced micronuclei in V79-hCYP1A2-hSULT1A1, V79-hSULT1A1, V79-hCYP1A1, and V79-hCYP1A2 cells, respectively. Benzo(a)pyrene 46-60 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 156-163 31112310-9 2020 Benzo[a]pyrene induced micronuclei in V79-Mz communicating with V79-hCYP1A1 via porous membranes, whereas aflatoxin B1 was inactive in V79-Mz communicating with V79-hCYP1A2. Benzo(a)pyrene 0-14 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 68-75 31655123-1 2020 Cytochrome P4501A1 (CYP1A1) is involved in the metabolism of several genotoxic/carcinogenic environmental xenobiotics including polycyclic aromatic hydrocarbons (PAHs) like benzo[a]pyrene. Benzo(a)pyrene 173-187 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-18 31655123-1 2020 Cytochrome P4501A1 (CYP1A1) is involved in the metabolism of several genotoxic/carcinogenic environmental xenobiotics including polycyclic aromatic hydrocarbons (PAHs) like benzo[a]pyrene. Benzo(a)pyrene 173-187 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 31885779-7 2019 CAE inhibited aryl hydrocarbon receptor (AhR) signaling by decreasing both XRE reporter activity and expression of cytochrome P450 1A1 (CYP1A1) induced by B[a]P treatment in HaCaT cells. Benzo(a)pyrene 155-160 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 115-134 31885779-7 2019 CAE inhibited aryl hydrocarbon receptor (AhR) signaling by decreasing both XRE reporter activity and expression of cytochrome P450 1A1 (CYP1A1) induced by B[a]P treatment in HaCaT cells. Benzo(a)pyrene 155-160 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 136-142 31092429-0 2019 Diallyl Trisulfide Enhances Benzo[a]pyrene-induced CYP1A1 Expression and Metabolic Activation in Hepatic HepG2 Cells. Benzo(a)pyrene 28-42 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 51-57 31092429-1 2019 BACKGROUND/AIM: Benzo[a]pyrene (BaP), an environmental pollutant produced by combustion processes, induces expression of cytochrome P450 (CYP) 1A1 via the activation of aryl hydrocarbon receptor (AHR). Benzo(a)pyrene 16-30 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 121-146 31092429-1 2019 BACKGROUND/AIM: Benzo[a]pyrene (BaP), an environmental pollutant produced by combustion processes, induces expression of cytochrome P450 (CYP) 1A1 via the activation of aryl hydrocarbon receptor (AHR). Benzo(a)pyrene 32-35 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 121-146 31092429-2 2019 Induced CYP1A1 is involved in BaP metabolism, resulting in either detoxification or metabolic activation in a context-dependent manner. Benzo(a)pyrene 30-33 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 8-14 31092429-5 2019 RESULTS: DATS enhanced BaP-induced CYP1A1 and CYP1B1 mRNA expression, BaP hydroxylation and BaP-DNA adduct formation. Benzo(a)pyrene 23-26 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 35-41 31092429-7 2019 DATS enhanced BaP-induced AHR recruitment and histone H3 acetylation on the CYP1A1 promoter. Benzo(a)pyrene 14-17 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 76-82 30439556-4 2019 In combination with BaP, butyrate potentiated induction of cytochrome P450 family 1 enzymes (CYP1A1), aldo-keto reductases (AKR1C1) or UDP-glucuronosyltransferases (UGT1A1). Benzo(a)pyrene 20-23 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 93-99 30137621-4 2018 Using AhR knockout variant of estrogen-sensitive human breast cancer MCF-7 cells (MCF-7 AhRKO cells), we observed that the AhR-dependent control of cytochrome P450 family 1 (CYP1) expression played a major role in formation of estrogenic BaP metabolites, most notably 3-OH-BaP, which contributed to the ER-dependent induction of cell cycle progression/cell proliferation. Benzo(a)pyrene 238-241 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 148-172 30204910-5 2019 This p23-mediated suppression of AHR is responsible for the suppression of (1) the ligand-dependent induction of the cyp1a1 gene transcription; (2) the benzo[a]pyrene- or cigarette smoke condensate-induced CYP1A1 enzyme activity, and (3) the benzo[a]pyrene and cigarette smoke condensate-mediated production of reactive oxygen species. Benzo(a)pyrene 152-166 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 117-123 30204910-5 2019 This p23-mediated suppression of AHR is responsible for the suppression of (1) the ligand-dependent induction of the cyp1a1 gene transcription; (2) the benzo[a]pyrene- or cigarette smoke condensate-induced CYP1A1 enzyme activity, and (3) the benzo[a]pyrene and cigarette smoke condensate-mediated production of reactive oxygen species. Benzo(a)pyrene 152-166 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 206-212 30204910-5 2019 This p23-mediated suppression of AHR is responsible for the suppression of (1) the ligand-dependent induction of the cyp1a1 gene transcription; (2) the benzo[a]pyrene- or cigarette smoke condensate-induced CYP1A1 enzyme activity, and (3) the benzo[a]pyrene and cigarette smoke condensate-mediated production of reactive oxygen species. Benzo(a)pyrene 242-256 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 117-123 30204910-5 2019 This p23-mediated suppression of AHR is responsible for the suppression of (1) the ligand-dependent induction of the cyp1a1 gene transcription; (2) the benzo[a]pyrene- or cigarette smoke condensate-induced CYP1A1 enzyme activity, and (3) the benzo[a]pyrene and cigarette smoke condensate-mediated production of reactive oxygen species. Benzo(a)pyrene 242-256 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 206-212 30137621-4 2018 Using AhR knockout variant of estrogen-sensitive human breast cancer MCF-7 cells (MCF-7 AhRKO cells), we observed that the AhR-dependent control of cytochrome P450 family 1 (CYP1) expression played a major role in formation of estrogenic BaP metabolites, most notably 3-OH-BaP, which contributed to the ER-dependent induction of cell cycle progression/cell proliferation. Benzo(a)pyrene 238-241 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 174-178 30137621-8 2018 Ectopic expression of human CYP1A1 and CYP1B1 enzymes partly restored both BaP metabolism and its effects on cell proliferation. Benzo(a)pyrene 75-78 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 28-34 30122317-11 2018 Our data also demonstrated that Benzo(a)pyrene (BaP) induced up to 100 folds of mRNA expression of CYP1A1 or CYP1A2 in CR-HNBE cells. Benzo(a)pyrene 32-46 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 99-105 29738693-8 2018 Additionally, compared with siRNA-transfected and benzo[a]pyrene (BaP)-OA-induced HepG2 cells, overexpression of CYP1A1 by BaP further accelerated the lipid peroxidation in OA-treated HepG2 cells. Benzo(a)pyrene 50-64 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 113-119 31458985-1 2018 Cytochrome P450 family 1 (CYP1) enzymes catalyze the metabolic activation of environmental procarcinogens such as benzo[a]pyrene, B[a]P, into carcinogens, which initiates the process of carcinogenesis. Benzo(a)pyrene 114-128 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-24 31458985-1 2018 Cytochrome P450 family 1 (CYP1) enzymes catalyze the metabolic activation of environmental procarcinogens such as benzo[a]pyrene, B[a]P, into carcinogens, which initiates the process of carcinogenesis. Benzo(a)pyrene 114-128 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 26-30 29458109-2 2018 CYP1A1 has become infamous for its oxidative metabolism of benzo[a]pyrene and related polycyclic aromatic hydrocarbons, converting these chemicals into very potent human carcinogens. Benzo(a)pyrene 59-73 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 28527150-5 2018 Like DBP, BP (-10.13 kcal/mol, Ki: 0.04 microM) and BP-diols (BPD) (-9.01 kcal/mol, Ki: 0.25 microM) observed plausible binding with CYP1A1 supporting to the reported data that emphasize the major contribution of CYP1A1 in the activation of similar procarcinogens and mutagens. Benzo(a)pyrene 6-8 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 133-139 28527150-5 2018 Like DBP, BP (-10.13 kcal/mol, Ki: 0.04 microM) and BP-diols (BPD) (-9.01 kcal/mol, Ki: 0.25 microM) observed plausible binding with CYP1A1 supporting to the reported data that emphasize the major contribution of CYP1A1 in the activation of similar procarcinogens and mutagens. Benzo(a)pyrene 6-8 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 213-219 28527150-9 2018 Further, molecular dynamics (MD) simulation of 10 ns has been revealed that docked complexes of CYP1A1 with DBP, DMBA and BP are comparatively more stable than the complex of PhIP. Benzo(a)pyrene 109-111 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 96-102 29545172-0 2018 Benzo[a]pyrene activates an AhR/Src/ERK axis that contributes to CYP1A1 induction and stable DNA adducts formation in lung cells. Benzo(a)pyrene 0-14 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 65-71 29471073-1 2018 Polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) can induce cytochrome P450 1A1 (CYP1A1) via a p53-dependent mechanism. Benzo(a)pyrene 41-55 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 73-92 29471073-1 2018 Polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) can induce cytochrome P450 1A1 (CYP1A1) via a p53-dependent mechanism. Benzo(a)pyrene 41-55 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 94-100 28882572-11 2017 Finally, knock-down of ARNT reduced gamma-H2AX in response to BaP, which was associated with reduced CYP1A1 expression. Benzo(a)pyrene 62-65 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 101-107 30108931-9 2018 Both isopimpinellin and karanjin negate the cellular toxicity of CYP1A1-mediated benzo[a]pyrene. Benzo(a)pyrene 81-95 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 65-71 28247504-3 2017 Co-treatment with 5 microM BaP and 20 microM EGCG in BEAS-2B promoted a significant reduction in cell viability and greater G2/M cell cycle arrest, induction of ROS, and reductions in BaP-induced CYP1A1/CYP1B1/COMT, EGFR, p-Akt (Ser473), p-p53 (Thr55), and survivin mRNA/protein expression, as well as an increase in p-p53 (Ser15). Benzo(a)pyrene 27-30 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 196-202 28461126-1 2017 Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are widely distributed environmental contaminants exerting toxic effects such as genotoxicity and carcinogenicity, mainly associated with aryl hydrocarbon receptor (AhR) activation and the subsequent induction of cytochromes P-450 (CYP) 1-metabolizing enzymes. Benzo(a)pyrene 49-63 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 286-311 28461126-1 2017 Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are widely distributed environmental contaminants exerting toxic effects such as genotoxicity and carcinogenicity, mainly associated with aryl hydrocarbon receptor (AhR) activation and the subsequent induction of cytochromes P-450 (CYP) 1-metabolizing enzymes. Benzo(a)pyrene 65-70 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 286-311 28247504-3 2017 Co-treatment with 5 microM BaP and 20 microM EGCG in BEAS-2B promoted a significant reduction in cell viability and greater G2/M cell cycle arrest, induction of ROS, and reductions in BaP-induced CYP1A1/CYP1B1/COMT, EGFR, p-Akt (Ser473), p-p53 (Thr55), and survivin mRNA/protein expression, as well as an increase in p-p53 (Ser15). Benzo(a)pyrene 184-187 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 196-202 27544633-2 2016 In human sebocytes, TCDD and BaP were found to activate the expression of multiple genes, including cytochrome P450 1A1 (CYP1A1), and inhibit lipid synthesis via AhR, while little is known about endogenous functions of the AhR. Benzo(a)pyrene 29-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 100-119 28489395-11 2017 The compound 119 rescued CYP1A1 overexpressing HEK293 cells from CYP1A1 mediated benzo[a]pyrene (B[a]P) toxicity and also overcame cisplatin resistance in CYP1B1 overexpressing HEK293 cells. Benzo(a)pyrene 81-95 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 25-31 28489395-11 2017 The compound 119 rescued CYP1A1 overexpressing HEK293 cells from CYP1A1 mediated benzo[a]pyrene (B[a]P) toxicity and also overcame cisplatin resistance in CYP1B1 overexpressing HEK293 cells. Benzo(a)pyrene 81-95 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 65-71 27830268-9 2017 This in vitro study suggests that butyrate, through modulation of histone acetylation, may potentiate induction of CYP1A1 expression, which might in turn alter the metabolism of BaP within colon epithelial cells. Benzo(a)pyrene 178-181 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 115-121 28405246-0 2017 Modulation of benzo[a]pyrene-DNA adduct formation by CYP1 inducer and inhibitor. Benzo(a)pyrene 14-28 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-57 28405246-4 2017 Therefore, AhR activators are suspected to have the potential to aggravate the toxicity of BaP through the induction of CYP1A1. Benzo(a)pyrene 91-94 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 120-126 28405246-5 2017 Besides, CYP1A1 inhibitors, including its substrates, are estimated to have preventive effects against BaP toxicity. Benzo(a)pyrene 103-106 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 9-15 28405246-10 2017 To interpret these complicated outcomes, we propose a hypothesis that CYP1A1 is a key enzyme for both generation and reduction of (+-)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), the major carcinogenic intermediate of BaP. Benzo(a)pyrene 224-227 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 70-76 27830268-2 2017 In this study, we investigated the impact of this histone deacetylase (HDAC) inhibitor on expression/activity of cytochrome P450 family 1 (CYP1) and on metabolism of carcinogenic polycyclic aromatic hydrocarbon, benzo[a]pyrene (BaP), in colon epithelial cells. Benzo(a)pyrene 212-226 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 139-143 27830268-2 2017 In this study, we investigated the impact of this histone deacetylase (HDAC) inhibitor on expression/activity of cytochrome P450 family 1 (CYP1) and on metabolism of carcinogenic polycyclic aromatic hydrocarbon, benzo[a]pyrene (BaP), in colon epithelial cells. Benzo(a)pyrene 228-231 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 113-137 27830268-2 2017 In this study, we investigated the impact of this histone deacetylase (HDAC) inhibitor on expression/activity of cytochrome P450 family 1 (CYP1) and on metabolism of carcinogenic polycyclic aromatic hydrocarbon, benzo[a]pyrene (BaP), in colon epithelial cells. Benzo(a)pyrene 228-231 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 139-143 27830268-3 2017 Sodium butyrate (NaBt) strongly potentiated the BaP-induced expression of CYP1A1 in human colon carcinoma HCT116 cells. Benzo(a)pyrene 48-51 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 74-80 27830268-5 2017 Up-regulation of CYP1A1 expression/activity corresponded with an enhanced metabolism of BaP and formation of covalent DNA adducts. Benzo(a)pyrene 88-91 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 17-23 29104317-0 2017 Comparison of human cytochrome P450 1A1-catalysed oxidation of benzo[a]pyrene in prokaryotic and eukaryotic expression systems. Benzo(a)pyrene 63-77 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-39 29104317-1 2017 Abstract: Cytochrome P450 (CYP) 1A1 is the most important enzyme activating and detoxifying the human carcinogen benzo[a]pyrene (BaP). Benzo(a)pyrene 113-127 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 10-35 29104317-1 2017 Abstract: Cytochrome P450 (CYP) 1A1 is the most important enzyme activating and detoxifying the human carcinogen benzo[a]pyrene (BaP). Benzo(a)pyrene 129-132 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 10-35 29104317-8 2017 Two BaP-derived DNA adducts were generated by the CYP1A1-Supersomes, both in the presence of NADPH and NADH, whereas NADPH but not NADH was able to support this reaction in the CYP1A1-Bactosomes. Benzo(a)pyrene 4-7 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 50-56 29104317-8 2017 Two BaP-derived DNA adducts were generated by the CYP1A1-Supersomes, both in the presence of NADPH and NADH, whereas NADPH but not NADH was able to support this reaction in the CYP1A1-Bactosomes. Benzo(a)pyrene 4-7 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 177-183 29104317-10 2017 Our study demonstrates different catalytic efficiencies of CYP1A1 expressed in prokaryotic and eukaryotic cells in BaP bioactivation indicating some limitations in the use of E. coli cells for such studies. Benzo(a)pyrene 115-118 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 59-65 27544633-2 2016 In human sebocytes, TCDD and BaP were found to activate the expression of multiple genes, including cytochrome P450 1A1 (CYP1A1), and inhibit lipid synthesis via AhR, while little is known about endogenous functions of the AhR. Benzo(a)pyrene 29-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 121-127 27684561-7 2016 RESULTS: Of the five PAHs tested, after chronic treatment only BaP (100 nM) showed a significant increase in the expression of CYP1A1, AOEs (SOD1 and catalase), ROS generation, caspase-3 cleavage activity, and cytotoxicity. Benzo(a)pyrene 63-66 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 127-133 27486223-5 2016 Also relative to human AHR, the Neandertal AHR exhibited 150-1000 times greater sensitivity to induction of Cyp1a1 and Cyp1b1 expression by PAHs (e.g., benzo(a)pyrene). Benzo(a)pyrene 152-166 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 108-114 27362771-0 2016 Resolvin D1 down-regulates CYP1A1 and PTGS2 gene in the HUVEC cells treated with benzo(a)pyrene. Benzo(a)pyrene 81-95 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 27-33 27362771-5 2016 RESULTS: RvD1 down-regulates cytochrome P450 (CYP1A1) and prostaglandin synthase 2 (PTGS2) gene expression in HUVEC cells exposed to BaP. Benzo(a)pyrene 133-136 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 46-52 27684561-8 2016 However, acute treatment with BaP showed only an increase in the mRNA expression of CYP1A1. Benzo(a)pyrene 30-33 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 84-90 27404282-0 2016 NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene. Benzo(a)pyrene 155-169 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 88-107 27575721-0 2016 Correction to NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene. Benzo(a)pyrene 169-183 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 102-121 27162022-8 2016 Our findings cumulatively suggest that resveratrol inhibits conversion of B(a)P into BPDE by modulating the transcriptional regulation of CYP1A1 and acting as an antioxidant thus prevents B(a)P-induced oxidative stress and testicular apoptosis. Benzo(a)pyrene 74-79 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 138-144 27924717-0 2016 Effects of benzo[a]pyrene, aromatic amines, and a combination of both on CYP1A1 activities in RT-4 human bladder papilloma cells. Benzo(a)pyrene 11-25 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 73-79 25995008-2 2016 Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the cytochrome P450 (CYP) 1A1-mediated biotransformation of BaP in vitro. Benzo(a)pyrene 132-135 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 186-211 25995008-2 2016 Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the cytochrome P450 (CYP) 1A1-mediated biotransformation of BaP in vitro. Benzo(a)pyrene 242-245 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 186-211 26919089-2 2016 In this study human recombinant CYPs (CYP1A1, 1A2, 1B1, 2A6, 2B6, 2C8, 2C9, 2C19, 2E1, 3A4, and 3A5) were expressed in Supersomes together with their reductases, NADPH:CYP oxidoreductase, epoxide hydrolase and cytochrome b5 , to investigate BaP metabolism. Benzo(a)pyrene 242-245 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 38-44 26919089-4 2016 Among these, BaP-7,8-dihydrodiol and BaP-9-ol, which are intermediates in BaP-derived DNA adduct formation, were mainly formed by CYP1A1 and 1B1, and to a lesser extent by CYP2C19 and 3A4. Benzo(a)pyrene 13-16 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 130-144 26919089-5 2016 BaP-3-ol, a metabolite that is a "detoxified" product of BaP, was formed by most human CYPs tested, although CYP1A1 and 1B1 produced it the most efficiently. Benzo(a)pyrene 0-3 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 109-123 26919089-7 2016 Our results indicate that hepatic CYP1A1 and CYP2C19 are most important in the activation of BaP to BaP-7,8-dihydrodiol, whereas CYP2C19, 3A4, and 1A1 are the major enzymes contributing to the formation of BaP-9-ol. Benzo(a)pyrene 93-96 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 34-40 27110038-8 2016 The results demonstrate that NADH can act as a sole electron donor for both the first and the second reduction of CYP1A1 during its reaction cycle catalyzing oxidation of BaP, and suggest that the NADH:cytochrome b5 reductase as the NADH-dependent reductase might substitute POR in this enzymatic system. Benzo(a)pyrene 171-174 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 114-120 25995008-2 2016 Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the cytochrome P450 (CYP) 1A1-mediated biotransformation of BaP in vitro. Benzo(a)pyrene 116-130 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 186-211 26963242-1 2016 In this study, we determined the effects of benzo(a)pyrene (BaP) on the expression of aryl hydrocarbon receptor (AhR) and cytochrome P450 1A1 (CYP1A1), and assessed the action of BaP on inflammatory cytokine expression and lipid synthesis in SZ95 sebocytes in vitro. Benzo(a)pyrene 44-58 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 143-149 25398514-8 2016 CYP1A1 is inducible via the aryl hydrocarbon receptor (AHR), but we did not find that expression of AHR was dependent on p53; rather, we found that BaP-induced CYP1A1 expression was regulated through p53 binding to a p53 response element in the CYP1A1 promoter region, thereby enhancing its transcription. Benzo(a)pyrene 148-151 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 25398514-8 2016 CYP1A1 is inducible via the aryl hydrocarbon receptor (AHR), but we did not find that expression of AHR was dependent on p53; rather, we found that BaP-induced CYP1A1 expression was regulated through p53 binding to a p53 response element in the CYP1A1 promoter region, thereby enhancing its transcription. Benzo(a)pyrene 148-151 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 160-166 25398514-8 2016 CYP1A1 is inducible via the aryl hydrocarbon receptor (AHR), but we did not find that expression of AHR was dependent on p53; rather, we found that BaP-induced CYP1A1 expression was regulated through p53 binding to a p53 response element in the CYP1A1 promoter region, thereby enhancing its transcription. Benzo(a)pyrene 148-151 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 160-166 27924717-2 2016 The aim of this study was to (1) examine the metabolic capacity of RT-4 human bladder papilloma cells and (2) investigate the influence of aromatic amines on the induction of cytochrome P-450 1A1 (CYP1A1) activity and their effects on benzo[a]pyrene (BaP)-induced CYP1A1 activities. Benzo(a)pyrene 235-249 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 197-203 27924717-2 2016 The aim of this study was to (1) examine the metabolic capacity of RT-4 human bladder papilloma cells and (2) investigate the influence of aromatic amines on the induction of cytochrome P-450 1A1 (CYP1A1) activity and their effects on benzo[a]pyrene (BaP)-induced CYP1A1 activities. Benzo(a)pyrene 251-254 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 197-203 27924717-6 2016 Concentration-dependent elevation in CYP1A1 activities accompanied by increasing protein levels was found after treating cells with BaP and 1- or 2-NA. Benzo(a)pyrene 132-135 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 37-43 27924717-9 2016 Our results suggest that RT-4 cells represent a reliable model cell line to study arylamine- and PAH-induced effects in vitro and that BaP-induced CYP1A1 activities are modulated by aromatic amines. Benzo(a)pyrene 135-138 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 147-153 25805023-6 2015 The increased formation of DNA adducts formed by BaP upon beta-catenin knockdown corresponded with enhanced production of major BaP metabolites, as well as with an increased expression/activity of CYP1 enzymes. Benzo(a)pyrene 49-52 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 197-201 25805023-7 2015 Finally, using siRNA-mediated knockdown of CYP1A1, we confirmed that this enzyme plays a major role in formation of BaP-induced DNA adducts in HCT116 cells. Benzo(a)pyrene 116-119 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 43-49 25805023-8 2015 Taken together, the present results indicated that the siRNA-mediated inhibition of beta-catenin signalling, which is aberrantly activated in a majority of colorectal cancers, modulated genotoxicity of dietary carcinogen BaP in colon cell model in vitro, via a mechanism involving up-regulation of CYP1 expression and activity. Benzo(a)pyrene 221-224 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 298-302 25199627-5 2014 First, BaP-induced expression of key metabolic enzymes was analysed; expression levels of the activating CYP1A1 and CYP1B1 were increased, while the detoxifying enzymes UGT1A6 and UGT2B7 were significantly reduced by hypoxia. Benzo(a)pyrene 7-10 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 105-111 25245543-0 2014 Correlation between CYP1A1 transcript, protein level, enzyme activity and DNA adduct formation in normal human mammary epithelial cell strains exposed to benzo[a]pyrene. Benzo(a)pyrene 154-168 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 25245543-5 2014 In cells exposed to 4.0 microM BP for 12h, RNA cpn values were 251-13234 for CYP1A1, 4133-57078 for CYP1B1 and 4456-55887 for NQO1. Benzo(a)pyrene 31-33 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 77-83 25245543-7 2014 In the NHMECs, BP-induced CYP1A1 RNA cpn was highly associated with BPdG (P = 0.002), but CYP1B1 and NQO1 were not. Benzo(a)pyrene 15-17 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 26-32 23994263-0 2014 Benzo[a]pyrene sensitizes MCF7 breast cancer cells to induction of G1 arrest by the natural flavonoid eupatorin-5-methyl ether, via activation of cell signaling proteins and CYP1-mediated metabolism. Benzo(a)pyrene 0-14 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 174-178 23994263-5 2014 More importantly, although E5M was less active than L in inhibiting proliferation of MCF7 cells, when the cells were pretreated with the CYP1 inducer Benzo[a]pyrene (BaP) the potency of E5M was augmented. Benzo(a)pyrene 150-164 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 137-141 23994263-5 2014 More importantly, although E5M was less active than L in inhibiting proliferation of MCF7 cells, when the cells were pretreated with the CYP1 inducer Benzo[a]pyrene (BaP) the potency of E5M was augmented. Benzo(a)pyrene 166-169 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 137-141 23994263-7 2014 E5M1 production in BaP-induced MCF7 cells was attenuated in the presence of the CYP1A1 inhibitor alpha-napthoflavone. Benzo(a)pyrene 19-22 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 80-86 23994263-10 2014 E5M antiproliferative effect in BaP pretreated cells was attenuated in the presence of the CYP1A1 inhibitor alpha-napthoflavone, as demonstrated by Western blotting and FACS analysis. Benzo(a)pyrene 32-35 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 91-97 23994263-11 2014 Taken together the results demonstrate that BaP sensitizes MCF7 cells to E5M antiproliferative activity via enhanced induction of p21, JNK and p-JNK that in turn results by cytochrome P450 CYP1-mediated conversion to the metabolite E5M1. Benzo(a)pyrene 44-47 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 189-193 25245543-10 2014 Despite more numerous levels of CYP1B1 and NQO1 RNA cpn in unexposed and BP-exposed NHMECs and MCF-7cells, BPdG formation was only correlated with induction of CYP1A1 RNA cpn. Benzo(a)pyrene 73-75 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 160-166 24588654-7 2014 L-NAC or knock-down of Nrf2 significantly attenuated the inhibitory effects of Z-Ligustilide on BaP-induced CYP1A1 upregulation in NHEKs. Benzo(a)pyrene 96-99 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 108-114 24532440-3 2014 The compound benzo-a-pyrene (BaP), a copious and noxious compound present in coal tar, automobile exhaust fumes, cigarette smoke and charbroiled food, is metabolised by CYP1A1 and has been studied in great detail. Benzo(a)pyrene 13-27 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 169-175 24532440-3 2014 The compound benzo-a-pyrene (BaP), a copious and noxious compound present in coal tar, automobile exhaust fumes, cigarette smoke and charbroiled food, is metabolised by CYP1A1 and has been studied in great detail. Benzo(a)pyrene 29-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 169-175 24736433-11 2014 Using p53 heterozygous mutant epithelial cells from patients with Li-Fraumeni syndrome, we show that monoallelic mutation of p53 was associated with elevated levels of CYP1A1 and CYP1B1 under both basal conditions and following treatment with benzo[a]pyrene. Benzo(a)pyrene 243-257 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 168-174 24736433-12 2014 Treatment with CP-31398, a p53 rescue compound, suppressed benzo[a]pyrene-mediated induction of CYP1A1 and CYP1B1 and the formation of DNA adducts. Benzo(a)pyrene 59-73 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 96-102 24588654-0 2014 Z-Ligustilide inhibits benzo(a)pyrene-induced CYP1A1 upregulation in cultured human keratinocytes via ROS-dependent Nrf2 activation. Benzo(a)pyrene 23-37 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 46-52 24588654-1 2014 UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation. Benzo(a)pyrene 12-26 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 123-141 24588654-1 2014 UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation. Benzo(a)pyrene 12-26 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 143-149 24588654-1 2014 UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation. Benzo(a)pyrene 28-31 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 123-141 24588654-1 2014 UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation. Benzo(a)pyrene 28-31 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 143-149 24588654-2 2014 Here, we investigated the effect of Z-Ligustilide, an active ingredient isolated from the medicinal plants Cnidium officinale and Angelica acutiloba, on BaP-induced CYP1A1 upregulation in normal human epidermal keratinocytes (NHEKs) as well as its underlying mechanisms. Benzo(a)pyrene 153-156 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 165-171 24588654-3 2014 Z-Ligustilide significantly inhibited BaP-induced CYP1A1 upregulation in NHEKs. Benzo(a)pyrene 38-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 50-56 24588654-8 2014 Taken together, these findings suggest that Z-Ligustilide can suppress BaP-induced CYP1A1 upregulation through ROS-dependent Nrf2 pathway activation and may be beneficial in preventing or treating BaP-induced skin damage. Benzo(a)pyrene 71-74 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 83-89 23626760-3 2013 Since ethical constraints do not permit methodologically rigorous studies in humans, this question was addressed by investigating the effect of the prototypical inducer benzo[a]pyrene (BP) on CYP1A1 and CYP1A2 in cirrhotic rats stratified according to the severity of liver dysfunction. Benzo(a)pyrene 169-183 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 192-198 23639521-0 2013 Sustained induction of cytochrome P4501A1 in human hepatoma cells by co-exposure to benzo[a]pyrene and 7H-dibenzo[c,g]carbazole underlies the synergistic effects on DNA adduct formation. Benzo(a)pyrene 84-98 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 23-41 23508959-2 2013 CYP1A1 is particularly well known for its ability to biotransform polycyclic aromatic hydrocarbons, such as benzo[a]pyrene in tobacco smoke, into carcinogens. Benzo(a)pyrene 108-122 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 23626760-3 2013 Since ethical constraints do not permit methodologically rigorous studies in humans, this question was addressed by investigating the effect of the prototypical inducer benzo[a]pyrene (BP) on CYP1A1 and CYP1A2 in cirrhotic rats stratified according to the severity of liver dysfunction. Benzo(a)pyrene 185-187 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 192-198 24664296-6 2014 While CYP1A1 and 1B1 were induced by BaP, these inductions were not significantly reduced by curcumin or VE. Benzo(a)pyrene 37-40 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 6-20 25638374-0 2014 Modulation of human cytochrome P450 1A1-mediated oxidation of benzo[a]pyrene by NADPH:cytochrome P450 oxidoreductase and cytochrome b5. Benzo(a)pyrene 62-76 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-39 25638374-1 2014 OBJECTIVES: Cytochrome P450 (CYP) 1A1 located in the membrane of endoplasmic reticulum is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (BaP), in combination with microsomal epoxide hydrolase (mEH). Benzo(a)pyrene 186-189 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 12-37 25638374-2 2014 However, it is still not clearly explained how the electron transfer is mediated by NADPH:CYP oxidoreductase (POR), another component of the microsomal enzymatic system, on CYP1A1 during BaP oxidation, and whether microsomal cytochrome b5 might influence this electron transfer. Benzo(a)pyrene 187-190 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 173-179 25638374-3 2014 METHODS: High performance liquid chromatography (HPLC) was employed for separation of BaP metabolites formed by enzymatic systems containing human CYP1A1. Benzo(a)pyrene 86-89 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 147-153 25638374-4 2014 RESULTS: Human CYP1A1 expressed with POR in eukaryotic and prokaryotic expression cellular systems, in microsomes of insect cells (Supersomes) and in a membrane fraction of Escherichia coli, respectively, and these enzyme systems reconstituted with purified cytochrome b5 were utilized to study BaP oxidation. Benzo(a)pyrene 295-298 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 15-21 25638374-5 2014 Human CYP1A1 expressed in Supersomes oxidized BaP to seven metabolites [7,8- and 9,10-dihydrodiols, 1,6-dione, 3,6-dione, 3- and 9-phenols, and a metabolite with unknown structure (Mx)], whereas this enzyme expressed in membranes of E. coli formed only the metabolites 1,6- and 3,6-diones, 3- and 9-phenols, and Mx. Benzo(a)pyrene 46-49 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 6-12 25638374-6 2014 Addition of cytochrome b5 to CYP1A1 expressed in the eukaryotic system led to a more than 2-fold increase in BaP metabolism, but had essentially no effect on BaP oxidation by CYP1A1 expressed in E. coli. Benzo(a)pyrene 109-112 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 29-35 25638374-7 2014 CONCLUSION: The effect of cytochrome b5 on CYP1A1 conformation and the electron transfer to this enzyme may contribute to the cytochrome b5-mediated stimulation of BaP oxidation. Benzo(a)pyrene 164-167 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 43-49 23036853-10 2013 Further experiments using "Tet-On" cytochrome P450 1A1-overexpressing cells and a recombinant cytochrome P450 1A1 enzyme demonstrated that this is the key enzyme involved in the biotransformation of BaP, that is, both production and inactivation of BPDE. Benzo(a)pyrene 199-202 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 94-113 23036853-0 2013 Dioxin suppresses benzo[a]pyrene-induced mutations and DNA adduct formation through cytochrome P450 1A1 induction and (+-)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide inactivation in human hepatoma cells. Benzo(a)pyrene 18-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 84-103 23036853-8 2013 Among the enzymes catalyzing BaP oxidation and conjugation, cytochrome P450 1A1, 1A2, 3A4 and UDP-glucuronosyltransferase 1A1 mRNAs were induced by the exposure to TCDD. Benzo(a)pyrene 29-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 60-79 23036853-10 2013 Further experiments using "Tet-On" cytochrome P450 1A1-overexpressing cells and a recombinant cytochrome P450 1A1 enzyme demonstrated that this is the key enzyme involved in the biotransformation of BaP, that is, both production and inactivation of BPDE. Benzo(a)pyrene 199-202 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 35-54 22374940-6 2012 Treatment of cell lines derived from oral leukoplakia (MSK-Leuk1) and skin (HaCaT) with benzo[a]pyrene (B[a]P), a prototypic PAH, induced CYP1A1 and CYP1B1 transcription, resulting in enhanced levels of message and protein. Benzo(a)pyrene 88-102 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 138-144 24362093-1 2013 OBJECTIVES: Cytochrome P450 (CYP) 1A1 is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (BaP), in combination with microsomal epoxide hydrolase (mEH). Benzo(a)pyrene 121-135 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 12-37 22837390-0 2012 Vitamin D receptor activation enhances benzo[a]pyrene metabolism via CYP1A1 expression in macrophages. Benzo(a)pyrene 39-53 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 69-75 22837390-1 2012 Benzo[a]pyrene (BaP) activates the aryl hydrocarbon (AHR) and induces the expression of genes involved in xenobiotic metabolism, including CYP1A1. Benzo(a)pyrene 0-14 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 139-145 23107701-5 2012 The extracts also inhibited the activity of CYP3A4, whose expression was induced by 1,25-dihydroxyvitamin D(3), and of CYP1A1, induced by benzo(a)pyrene. Benzo(a)pyrene 138-152 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 119-125 22581694-4 2012 The transduction of AhR from the cytoplasm to the nucleus and the increase of AhR-responsive genes; that is, cytochrome P450 1A1 (CYP1A1), cytochrome P450 1B1 (CYP1B1), and aryl-hydrocarbon receptor repressor (AhRR), expression was induced by BaP exposure in both HPDLCs. Benzo(a)pyrene 243-246 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 109-128 25683418-7 2012 This study indicates that quercetin metabolites decrease the BaP-induced harmful effect of beta-carotene in A549 cells by downregulating the expression of CYP1A1/1A2, at least in part. Benzo(a)pyrene 61-64 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 155-161 22470100-1 2012 Cytochrome P450 1A1 (CYP1A1) is a member of the cytochrome p450 enzyme family, which is involved in the metabolisms of carcinogenic metabolites, such as benzo(a)pyrene. Benzo(a)pyrene 165-179 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 22470100-1 2012 Cytochrome P450 1A1 (CYP1A1) is a member of the cytochrome p450 enzyme family, which is involved in the metabolisms of carcinogenic metabolites, such as benzo(a)pyrene. Benzo(a)pyrene 165-179 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 22470100-5 2012 Of note, benzo(a)pyrene, a major inducer of CYP1A1 transcription, decreased the expression of miR-892a. Benzo(a)pyrene 9-23 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 44-50 22470100-6 2012 Moreover, the miR-892a-induced CYP1A1 repression inhibited the benzo(a)pyrene-mediated decrease in cell viability. Benzo(a)pyrene 75-89 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 31-37 21720915-7 2011 Results obtained showed that HE/HP-beta-CyD was also able to reduce BaP-induced AhR and CYP1A1 protein expression (p<0.001). Benzo(a)pyrene 68-71 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 88-94 21920623-8 2012 Benzo[a]pyrene increased expression of CYP1B1 over CYP1A1 and suppressed estrogen-induced COMT up-regulation in ERalpha(-) tumor cells, probably switching estrogen metabolism to 4-hydroxyestradiol formation and removing the inhibition of 2-methoxyestradiol on ERalpha(-) tumors. Benzo(a)pyrene 0-14 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 51-57 21920623-9 2012 ERalpha inhibited AhR from up-regulating CYP1 in response to benzo[a]pyrene exposure, but it increased angiogenic VEGF-A expression with body estrogen levels. Benzo(a)pyrene 61-75 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 41-45 20951464-8 2011 The results also revealed significant sex differences in CYP1A1 gene expression, both in untreated cells (p=0.03), and in cells exposed to benzo[a]pyrene (p=0.017) and cigarette smoke condensate (p=0.0043). Benzo(a)pyrene 139-153 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 57-63 21669939-6 2011 The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 muM BP, 1 muM BP + 1 muM TMS or 1 muM BP + 4 muM TMS, respectively. Benzo(a)pyrene 180-182 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 26-32 21669939-6 2011 The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 muM BP, 1 muM BP + 1 muM TMS or 1 muM BP + 4 muM TMS, respectively. Benzo(a)pyrene 190-192 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 26-32 21669939-6 2011 The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 muM BP, 1 muM BP + 1 muM TMS or 1 muM BP + 4 muM TMS, respectively. Benzo(a)pyrene 190-192 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 26-32 21669939-8 2011 Therefore, during 96 h of exposure in MCF-7 cells, the combination of BP plus TMS caused a slowing of BP biotransformation, with an increase in CYP1A1 and CYP1B1 expression and EROD activity, and a slowing, but no change in magnitude of BPdG formation. Benzo(a)pyrene 70-72 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 144-150 21292640-2 2011 Previous studies from our laboratory have shown that contingent on binding to its cognate promoter motifs in the Cyp1a1 gene, activation of the aryl hydrocarbon receptor (AHR) by benzo[a]pyrene (BaP) treatment induces histone modifications in the Cyp1a1 promoter that are required for activation of gene transcription. Benzo(a)pyrene 179-193 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 113-119 21292640-2 2011 Previous studies from our laboratory have shown that contingent on binding to its cognate promoter motifs in the Cyp1a1 gene, activation of the aryl hydrocarbon receptor (AHR) by benzo[a]pyrene (BaP) treatment induces histone modifications in the Cyp1a1 promoter that are required for activation of gene transcription. Benzo(a)pyrene 179-193 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 247-253 21292640-2 2011 Previous studies from our laboratory have shown that contingent on binding to its cognate promoter motifs in the Cyp1a1 gene, activation of the aryl hydrocarbon receptor (AHR) by benzo[a]pyrene (BaP) treatment induces histone modifications in the Cyp1a1 promoter that are required for activation of gene transcription. Benzo(a)pyrene 195-198 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 113-119 21292640-2 2011 Previous studies from our laboratory have shown that contingent on binding to its cognate promoter motifs in the Cyp1a1 gene, activation of the aryl hydrocarbon receptor (AHR) by benzo[a]pyrene (BaP) treatment induces histone modifications in the Cyp1a1 promoter that are required for activation of gene transcription. Benzo(a)pyrene 195-198 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 247-253 21507987-3 2011 BRCA1 knockdown in MCF-10A cells significantly attenuated the induction of CYP1A1 following BaP treatment indicating that the increase in BaP-induced adducts in BRCA1 knockdown cells is not CYP1A1 dependent. Benzo(a)pyrene 92-95 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 75-81 21507987-3 2011 BRCA1 knockdown in MCF-10A cells significantly attenuated the induction of CYP1A1 following BaP treatment indicating that the increase in BaP-induced adducts in BRCA1 knockdown cells is not CYP1A1 dependent. Benzo(a)pyrene 138-141 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 75-81 21453744-5 2011 Like benzo-[a]-pyrene (B[a]P), a well known AHR ligand, T-2 led to cytochrome P450 1A1 (CYP1A1) mRNA expression in Caco-2 cells, which could be inhibited by the AHR antagonist resveratrol. Benzo(a)pyrene 5-21 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 67-86 21453744-5 2011 Like benzo-[a]-pyrene (B[a]P), a well known AHR ligand, T-2 led to cytochrome P450 1A1 (CYP1A1) mRNA expression in Caco-2 cells, which could be inhibited by the AHR antagonist resveratrol. Benzo(a)pyrene 5-21 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 88-94 20399842-2 2010 BP is converted in liver and lung to benzo(a)pyrene-7,8-diol-9,10-epoxide (BPDE) by the enzymes of the cytochrome P450 (CYP) superfamily, namely CYP1A1/1A2, and CYP1B1. Benzo(a)pyrene 0-2 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 145-151 20542099-3 2010 When analyzing the effect of BaP on the induction of CYP1 enzymes participating in the metabolic activation of PAHs in LNCaP cells, we found that BaP induced expression of CYP1A1 and CYP1A2, but not CYP1B1 enzyme. Benzo(a)pyrene 146-149 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-57 20542099-3 2010 When analyzing the effect of BaP on the induction of CYP1 enzymes participating in the metabolic activation of PAHs in LNCaP cells, we found that BaP induced expression of CYP1A1 and CYP1A2, but not CYP1B1 enzyme. Benzo(a)pyrene 29-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-57 20542099-3 2010 When analyzing the effect of BaP on the induction of CYP1 enzymes participating in the metabolic activation of PAHs in LNCaP cells, we found that BaP induced expression of CYP1A1 and CYP1A2, but not CYP1B1 enzyme. Benzo(a)pyrene 146-149 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 172-178 20163913-2 2010 Here, we examined the induction and modulation of CYP1A1 and CYP1B1 and 10-(deoxyguanosin-N(2)-yl)-7,8,9-trihydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPdG) adduct formation in DNA from 20 primary normal human mammary epithelial cell (NHMEC) strains exposed to BP (4muM) in the absence or presence of chlorophyllin (5muM). Benzo(a)pyrene 151-153 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 50-56 20553787-10 2010 Chrysoeriol (1-10 microM) dose-dependently inhibited both EROD activity and the gene expressions of CYP1A1, 1B1 and 1A2 stimulated by treatment with BaP. Benzo(a)pyrene 149-152 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 100-111 20163913-0 2010 CYP1A1 and CYP1B1 gene expression and DNA adduct formation in normal human mammary epithelial cells exposed to benzo[a]pyrene in the absence or presence of chlorophyllin. Benzo(a)pyrene 111-125 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 20435083-0 2010 Cytochromes P4501 (CYP1): catalytic activities and inducibility by diesel exhaust particle extract and benzo[a]pyrene in intact human lung ex vivo. Benzo(a)pyrene 103-117 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-17 20435083-0 2010 Cytochromes P4501 (CYP1): catalytic activities and inducibility by diesel exhaust particle extract and benzo[a]pyrene in intact human lung ex vivo. Benzo(a)pyrene 103-117 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 19-23 20163913-3 2010 Real-time polymerase chain reaction (RT-PCR) analysis revealed strong induction of both CYP1A1 and CYP1B1 by BP, with high levels of inter-individual variability. Benzo(a)pyrene 109-111 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 88-94 20163913-5 2010 Chlorophyllin mitigated BP-induced CYP1A1 and CYP1B1 gene expression in all 20 strains when administered with BP. Benzo(a)pyrene 24-26 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 35-41 20307623-0 2010 Exposure of human skin to benzo[a]pyrene: role of CYP1A1 and aryl hydrocarbon receptor in oxidative stress generation. Benzo(a)pyrene 26-40 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 50-56 20307623-2 2010 BaP is known to bind with high specificity to the aryl hydrocarbon receptor (AhR), modifying the expression of CYP1A1, involved both in cancer and inflammation. Benzo(a)pyrene 0-3 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 111-117 20307623-4 2010 AhR and CYP1A1 expression was evaluated by Western blotting, which revealed their presence even in control untreated skin; both enzyme and receptor increased more than twofold after exposure to BaP. Benzo(a)pyrene 194-197 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 8-14 20307623-8 2010 The results of this experiment indicate that BaP, an AhR agonist, can significantly increase receptor and CYP1A1 expression and induce oxidative stress in human skin, confirming the involvement of this pathway in the pathogenesis of tissue damage due to polycyclic aromatic hydrocarbons. Benzo(a)pyrene 45-48 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 106-112 19553035-5 2009 We found that the exposure to BaP or PCB126 alone could effectively increase the CYP1A1 activity and the XPA expression. Benzo(a)pyrene 30-33 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 81-87 19896525-2 2010 Therefore the decrease in the BaP-induced Cyp1a1 protein level was not due to inhibition of Akr1c1, but to phen itself. Benzo(a)pyrene 30-33 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 42-48 19896525-3 2010 Phen decreased the BaP-induced Cyp1a1 promoter activity and protein expression, and in contrast, it increased Cyp1a1 mRNA, resulting from an increase in mRNA stability. Benzo(a)pyrene 19-22 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 31-37 19919601-1 2010 Administration of melatonin to rodents decreases the incidence of tumorigenesis initiated by benzo[a]pyrene or 7,12-dimethylbenz[a]anthracene, which requires bioactivation by cytochrome P450 enzymes, such as CYP1A1, CYP1A2 and CYP1B1, to produce carcinogenic metabolites. Benzo(a)pyrene 93-107 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 208-214 19961161-7 2009 When Cyp1a1"s turnover was examined, 1-NP was able to stabilize the 1-NP- and benzo[a]pyrene (BaP)-induced Cyp1a1 mRNA, but not protein. Benzo(a)pyrene 78-92 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 107-113 19961161-7 2009 When Cyp1a1"s turnover was examined, 1-NP was able to stabilize the 1-NP- and benzo[a]pyrene (BaP)-induced Cyp1a1 mRNA, but not protein. Benzo(a)pyrene 94-97 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 5-11 19961161-7 2009 When Cyp1a1"s turnover was examined, 1-NP was able to stabilize the 1-NP- and benzo[a]pyrene (BaP)-induced Cyp1a1 mRNA, but not protein. Benzo(a)pyrene 94-97 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 107-113 20371965-6 2010 Moreover, it was shown that cotreatment with MDA-LDL and BaP markedly induced the expression of human cytochrome P4501A1 (hCYP1A1) messenger ribonucleic acid (mRNA) and significantly induced the expressions of p53 and p21 mRNAs. Benzo(a)pyrene 57-60 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 102-120 20371965-6 2010 Moreover, it was shown that cotreatment with MDA-LDL and BaP markedly induced the expression of human cytochrome P4501A1 (hCYP1A1) messenger ribonucleic acid (mRNA) and significantly induced the expressions of p53 and p21 mRNAs. Benzo(a)pyrene 57-60 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 122-129 20654143-1 2010 OBJECTIVE: To investigate cytotoxicity and genotoxicity of benzo(a)pyrene (B(a)P) by 16HBE-CYP1A1 cells which are human bronchial epithelial cell with CYP1A1 transformed. Benzo(a)pyrene 59-73 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 91-97 20654143-1 2010 OBJECTIVE: To investigate cytotoxicity and genotoxicity of benzo(a)pyrene (B(a)P) by 16HBE-CYP1A1 cells which are human bronchial epithelial cell with CYP1A1 transformed. Benzo(a)pyrene 59-73 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 151-157 19879933-0 2010 Importance of CYP1A1 and CYP1B1 in bioactivation of benzo[a]pyrene in human lung cell lines. Benzo(a)pyrene 52-66 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-20 19553035-8 2009 The synergistic effect of PCB126 on BaP-induced MN formation was inhibited by alpha-naphthoflavone (ANF), an inhibitor of CYP1A1. Benzo(a)pyrene 36-39 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 122-128 19553035-7 2009 Compared with BaP alone, co-exposure to both BaP and PCB126 significantly enhanced the CYP1A1 activity and the formation of MN but reduced the expression of both XPA and XPC. Benzo(a)pyrene 45-48 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 87-93 19406224-7 2009 Gene expression analysis at 4 and 24h following benzo(a)pyrene exposure revealed the induction of cyp1a1, cyp1a2, and cyp1b1 in FE1 cells and lung isolates. Benzo(a)pyrene 48-62 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 98-104 18372000-6 2008 Expression of CYP1A1 and CYP1A2, but not CYP1B1, inhibited DNA adduct formation in BaP-treated HepG2 cells. Benzo(a)pyrene 83-86 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-20 19152381-7 2009 Using reverse transcription real time PCR (RT-PCR) the maximal inhibition of BP-induced gene expression, >85% for CYP1A1 and >70% for CYP1B1, was observed in the preCHLN, postBP+CHLN group. Benzo(a)pyrene 77-79 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 117-123 19152381-11 2009 Therefore, the addition of CHLN to BP-exposed cells reduced BPdG formation and CYP1A1 and CYP1B1 expression, but EROD activity was not significantly reduced. Benzo(a)pyrene 35-37 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 79-85 19202560-0 2009 Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene. Benzo(a)pyrene 77-91 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 39-45 19202560-6 2009 The aim of the study was to determine whether the differences in the isothiocyanate structure change its ability to inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene in HepG2 and Mcf7 cells. Benzo(a)pyrene 162-176 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 124-130 18793272-0 2008 Omeprazole alleviates benzo[a]pyrene cytotoxicity by inhibition of CYP1A1 activity in human and mouse hepatoma cells. Benzo(a)pyrene 22-36 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 67-73 18793272-3 2008 CYP1A1-inducible chemicals, such as benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin, are known to have adverse effects (i.e. carcinogenesis, mutagenesis and malformation). Benzo(a)pyrene 36-50 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 18372000-0 2008 Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene. Benzo(a)pyrene 133-147 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 84-88 18372000-2 2008 BaP activates the aryl hydrocarbon receptor (AhR) and induces the expression of a battery of genes, including CYP1A1, which metabolize BaP to toxic compounds. Benzo(a)pyrene 0-3 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 110-116 18372000-2 2008 BaP activates the aryl hydrocarbon receptor (AhR) and induces the expression of a battery of genes, including CYP1A1, which metabolize BaP to toxic compounds. Benzo(a)pyrene 135-138 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 110-116 18372000-4 2008 In this study, we assessed the effects of CYP1 enzymes (CYP1A1, CYP1A2 and CYP1B1) on BaP-induced AhR transactivation and DNA adduct formation in HEK293 cells and HepG2 cells. Benzo(a)pyrene 86-89 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 42-46 18372000-4 2008 In this study, we assessed the effects of CYP1 enzymes (CYP1A1, CYP1A2 and CYP1B1) on BaP-induced AhR transactivation and DNA adduct formation in HEK293 cells and HepG2 cells. Benzo(a)pyrene 86-89 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 56-62 18372000-5 2008 Transfection of CYP1A1 and CYP1B1, but not CYP1A2, suppressed BaP-induced activation of AhR. Benzo(a)pyrene 62-65 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 16-22 18797853-4 2008 Our studies were carried out with metabolically competent primary porcine urinary bladder epithelial cells (PUBECs) and the human urothelial cell line 5637 for which we have previously demonstrated CYP1A1 mRNA induction by the polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (B[a]P) applying real-time RT-PCR. Benzo(a)pyrene 265-279 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 198-204 18372000-7 2008 These results indicate that CYP1A1 and CYP1B1 play a role in deactivation of BaP on AhR and that CYP1A1 and CYP1A2 are involved in BaP detoxification by suppressing DNA adduct formation. Benzo(a)pyrene 77-80 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 28-34 18372000-10 2008 Dynamic expression of CYP1A1, CYP1A2 and CYP1B1 along with expression of other enzymes such as epoxide hydrolase and phase II enzymes may determine the detoxification or metabolic activation of BaP. Benzo(a)pyrene 194-197 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 22-28 17919675-0 2008 Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites. Benzo(a)pyrene 59-73 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-19 18160334-9 2008 The genotoxicity of BaP that is metabolically activated in V79 cells stably expressing human cytochrome P450-dependent monooxygenase (CYP1A1) as well as human epoxide hydrolase (V79-hCYP1A1-mEH) could not be detected with the comet assay performed under yellow light. Benzo(a)pyrene 20-23 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 134-140 18569604-0 2008 Evaluation of time dependence and interindividual differences in benzo[a]pyrene-mediated CYP1A1 induction and genotoxicity in porcine urinary bladder cell cultures. Benzo(a)pyrene 65-79 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 89-95 18569604-4 2008 In a preceding study, it was demonstrated using cultured porcine urinary bladder epithelial cells (PUBEC) that CYP1A1 mRNA is induced in a potent manner by treatment with benzo[a]pyrene (BaP). Benzo(a)pyrene 171-185 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 111-117 18569604-4 2008 In a preceding study, it was demonstrated using cultured porcine urinary bladder epithelial cells (PUBEC) that CYP1A1 mRNA is induced in a potent manner by treatment with benzo[a]pyrene (BaP). Benzo(a)pyrene 187-190 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 111-117 18569604-8 2008 Interindividual differences were found between PUBEC cultures derived from several donor animals with respect to the response to BaP, such that the extent of CYP1A1 induction and magnitude of DNA damage was interrelated. Benzo(a)pyrene 129-132 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 158-164 18569596-4 2008 Recently in PUBEC cultures derived from pools of several bladders potent induction of CYP1A1 was detected after BaP treatment. Benzo(a)pyrene 112-115 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 86-92 18569596-5 2008 Results from a modified approach using miniaturized PUBEC cultures for the analysis of individual bladder specimens with regard to cell growth and to BaP-mediated induction of CYP1A1 mRNA expression are presented herein. Benzo(a)pyrene 150-153 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 176-182 17919675-3 2008 Time course studies showed that induction of CYP1-catalyzed E(2) metabolism persisted after the disappearance of BKF or co-exposed benzo(a)pyrene, suggesting that BKF metabolites retaining Ah receptor agonist activity were responsible for prolonged CYP1 induction. Benzo(a)pyrene 131-145 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 45-49 17640999-0 2007 Benzo[a]pyrene induces apoptosis in RL95-2 human endometrial cancer cells by cytochrome P450 1A1 activation. Benzo(a)pyrene 0-14 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 77-96 17682057-3 2007 To test this hypothesis, we coexposed cells to binary mixtures of benzo[a]pyrene (B[a]P), an environmental procarcinogen that activates Cyp1a1 transcriptional responses mediated by the aryl hydrocarbon receptor (AHR), and chromium, a carcinogenic heavy metal that represses B[a]P-inducible AHR-mediated gene expression. Benzo(a)pyrene 66-80 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 136-142 17707923-1 2007 Metabolic bioactivation of polycyclic aromatic hydrocarbons, such as the environmental procarcinogen benzo[a]pyrene, is catalyzed by a cytochrome P450 monooxygenase encoded by the substrate-inducible Cyp1a1 gene. Benzo(a)pyrene 101-115 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 200-206 16226778-8 2006 G. biloba extract also reduced benzo[a]pyrene hydroxylation, and the effect was greater with CYP1B1 than with CYP1A1 as the catalyst. Benzo(a)pyrene 31-45 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 110-116 17163506-3 2007 In the present study, we have evaluated the roles of CYP1A1 and dihydrodiol dehydrogenase (DDH) in the formation of benzo[a]pyrene (BaP) DNA adducts in various lung cancer cell lines. Benzo(a)pyrene 116-130 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-59 17163506-3 2007 In the present study, we have evaluated the roles of CYP1A1 and dihydrodiol dehydrogenase (DDH) in the formation of benzo[a]pyrene (BaP) DNA adducts in various lung cancer cell lines. Benzo(a)pyrene 132-135 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-59 17630984-5 2007 In silico docking showed alteration of the substrate access channel in exon 6 del CYP1A1 such that benzo(a)pyrene does not bind in any orientation that would permit the formation of carcinogenic metabolites. Benzo(a)pyrene 99-113 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 82-88 17485391-2 2007 Benz(a)pyrene and nitrosamine, typical carcinogens in cigarette smoke, undergo metabolic activation by the phase I enzymes, such as cytochrome P450 (CYP) 1A1, CYP2A6 and CYP2E1. Benzo(a)pyrene 0-13 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 132-157 17261025-5 2007 Using benzo[a]pyrene as a test substrate, enzyme activity for producing DNA damage in the arrays was found in the order CYP1B1 > CYP1A2 > CYP1A1 > CYP2E1 > myoglobin, the same as the order of their metabolic activity. Benzo(a)pyrene 6-20 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 144-150 16484233-4 2006 BaP exposure also increased both CYP1A1/1B1 and microsomal epoxide hydrolase (mEH) enzyme activities with a maximum 10-fold increase at 48 h. BaP induced CYP1A1 protein and mRNA levels maximally after 48 h. In contrast, although CYP1B1 mRNA was rapidly induced, its protein expression showed a very poor response. Benzo(a)pyrene 0-3 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 33-43 16484233-4 2006 BaP exposure also increased both CYP1A1/1B1 and microsomal epoxide hydrolase (mEH) enzyme activities with a maximum 10-fold increase at 48 h. BaP induced CYP1A1 protein and mRNA levels maximally after 48 h. In contrast, although CYP1B1 mRNA was rapidly induced, its protein expression showed a very poor response. Benzo(a)pyrene 0-3 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 33-39 16484233-4 2006 BaP exposure also increased both CYP1A1/1B1 and microsomal epoxide hydrolase (mEH) enzyme activities with a maximum 10-fold increase at 48 h. BaP induced CYP1A1 protein and mRNA levels maximally after 48 h. In contrast, although CYP1B1 mRNA was rapidly induced, its protein expression showed a very poor response. Benzo(a)pyrene 142-145 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 33-43 16484233-4 2006 BaP exposure also increased both CYP1A1/1B1 and microsomal epoxide hydrolase (mEH) enzyme activities with a maximum 10-fold increase at 48 h. BaP induced CYP1A1 protein and mRNA levels maximally after 48 h. In contrast, although CYP1B1 mRNA was rapidly induced, its protein expression showed a very poor response. Benzo(a)pyrene 142-145 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 33-39 16484233-10 2006 Most importantly, western blotting showed all three polyphenols dramatically reducing BaP-induced CYP1A1 protein expression. Benzo(a)pyrene 86-89 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 98-104 16484233-12 2006 In summary, BaP exposure results in a high level of DNA binding in BEAS-2B cells, which is mainly mediated by induction of CYP1A1 protein, just as in the human lung. Benzo(a)pyrene 12-15 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 123-129 16484233-13 2006 Two methoxylated dietary flavonoids with highly specific effects on BaP bioactivation block this DNA binding and CYP1A1 protein expression as effectively as RV, thus making them potential chemopreventive agents for BaP-induced lung carcinogenesis. Benzo(a)pyrene 68-71 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 113-119 16773535-7 2006 mRNA expression of CYP1A1 or CYP1A2 induced by the promutagen benzo[a]pyrene was significantly down-regulated by EGCG but not by GTE. Benzo(a)pyrene 62-76 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 19-25 16737584-1 2006 OBJECTIVE: To explore the relationship between genetic polymorphisms of CYP-1A1 and CYP2D6 and risks of chronic benzene poisoning (BP). Benzo(a)pyrene 131-133 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 72-79 16611024-1 2006 Cytochrome P450 (CYP) 1A1 attracts attention mainly because of its role in production of carcinogenic reactive metabolites from polycyclic aromatic hydrocarbons such as benzo[a]pyrene, but recent developments indicate its apparent role in cell cycle progression. Benzo(a)pyrene 169-183 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-25 16280210-3 2006 To further investigate the molecular mechanism by which 1-NP interferes with the covalent binding of BaP to DNA, we conducted experiments to analyze the mRNA level and protein stability of cytochrome P450 1A1 (CYP1A1), which is engaged in the activation of BaP, leading to the generation of BaP-DNA adducts. Benzo(a)pyrene 257-260 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 210-216 16280210-0 2006 Suppressive effect of 1-nitropyrene on benzo[a]pyrene-induced CYP1A1 protein expression in HepG2 cells. Benzo(a)pyrene 39-53 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 62-68 16280210-3 2006 To further investigate the molecular mechanism by which 1-NP interferes with the covalent binding of BaP to DNA, we conducted experiments to analyze the mRNA level and protein stability of cytochrome P450 1A1 (CYP1A1), which is engaged in the activation of BaP, leading to the generation of BaP-DNA adducts. Benzo(a)pyrene 101-104 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 189-208 16280210-3 2006 To further investigate the molecular mechanism by which 1-NP interferes with the covalent binding of BaP to DNA, we conducted experiments to analyze the mRNA level and protein stability of cytochrome P450 1A1 (CYP1A1), which is engaged in the activation of BaP, leading to the generation of BaP-DNA adducts. Benzo(a)pyrene 101-104 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 210-216 16280210-3 2006 To further investigate the molecular mechanism by which 1-NP interferes with the covalent binding of BaP to DNA, we conducted experiments to analyze the mRNA level and protein stability of cytochrome P450 1A1 (CYP1A1), which is engaged in the activation of BaP, leading to the generation of BaP-DNA adducts. Benzo(a)pyrene 257-260 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 189-208 16426572-6 2006 Furthermore, formation of total benzo(a)pyrene (BaP)-DNA adducts was not altered following BaP exposure in TCDD-treated primary hepatocytes, whereas significantly elevated, in a CYP1A1-dependent manner, in the treated HepG2 cells. Benzo(a)pyrene 32-46 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 178-184 16426572-6 2006 Furthermore, formation of total benzo(a)pyrene (BaP)-DNA adducts was not altered following BaP exposure in TCDD-treated primary hepatocytes, whereas significantly elevated, in a CYP1A1-dependent manner, in the treated HepG2 cells. Benzo(a)pyrene 48-51 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 178-184 16280210-3 2006 To further investigate the molecular mechanism by which 1-NP interferes with the covalent binding of BaP to DNA, we conducted experiments to analyze the mRNA level and protein stability of cytochrome P450 1A1 (CYP1A1), which is engaged in the activation of BaP, leading to the generation of BaP-DNA adducts. Benzo(a)pyrene 257-260 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 189-208 16280210-3 2006 To further investigate the molecular mechanism by which 1-NP interferes with the covalent binding of BaP to DNA, we conducted experiments to analyze the mRNA level and protein stability of cytochrome P450 1A1 (CYP1A1), which is engaged in the activation of BaP, leading to the generation of BaP-DNA adducts. Benzo(a)pyrene 257-260 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 210-216 16280210-4 2006 Northern blot analysis presented that 1-NP attenuated BaP-induced CYP1A1 mRNA expression by 30.4-39.6% (p < 0.05). Benzo(a)pyrene 54-57 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 66-72 16280210-5 2006 Western blot analysis revealed that the co-treatment with BaP and 1-NP resulted in a significant inhibition of BaP-induced CYP1A1 protein expression (70.7-88.2%, p < 0.05). Benzo(a)pyrene 58-61 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 123-129 16280210-5 2006 Western blot analysis revealed that the co-treatment with BaP and 1-NP resulted in a significant inhibition of BaP-induced CYP1A1 protein expression (70.7-88.2%, p < 0.05). Benzo(a)pyrene 111-114 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 123-129 16280210-9 2006 In addition, the relative levels of reactive oxygen species (ROS) were elevated in HepG2 cells co-treated with BaP and 1-NP, indicating that the decrease of CYP1A1 protein level was probably attributed to the production of ROS generated by binary mixture. Benzo(a)pyrene 111-114 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 157-163 16280210-10 2006 Taken together, these findings suggested that the transcriptional suppression and posttranslational mechanism may be involved in loss of CYP1A1 protein, causing the decrease of BaP-DNA adduct levels in the presence of binary mixtures of 1-NP and BaP. Benzo(a)pyrene 177-180 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 137-143 16280210-10 2006 Taken together, these findings suggested that the transcriptional suppression and posttranslational mechanism may be involved in loss of CYP1A1 protein, causing the decrease of BaP-DNA adduct levels in the presence of binary mixtures of 1-NP and BaP. Benzo(a)pyrene 246-249 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 137-143 16191477-3 2006 Typical inducers of the cytochrome P4501A1 (CYP1A1), such as TCDD, benzo(a)pyrene (B(a)P) and 3-methylcholanthrene, have a planar molecular structure in common and bind to the aryl hydrocarbon receptor (AhR). Benzo(a)pyrene 67-81 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 24-42 16191477-3 2006 Typical inducers of the cytochrome P4501A1 (CYP1A1), such as TCDD, benzo(a)pyrene (B(a)P) and 3-methylcholanthrene, have a planar molecular structure in common and bind to the aryl hydrocarbon receptor (AhR). Benzo(a)pyrene 67-81 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 44-50 16191477-3 2006 Typical inducers of the cytochrome P4501A1 (CYP1A1), such as TCDD, benzo(a)pyrene (B(a)P) and 3-methylcholanthrene, have a planar molecular structure in common and bind to the aryl hydrocarbon receptor (AhR). Benzo(a)pyrene 83-88 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 24-42 16191477-3 2006 Typical inducers of the cytochrome P4501A1 (CYP1A1), such as TCDD, benzo(a)pyrene (B(a)P) and 3-methylcholanthrene, have a planar molecular structure in common and bind to the aryl hydrocarbon receptor (AhR). Benzo(a)pyrene 83-88 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 44-50 16237193-8 2006 BaP- and TCDD-induced mRNA and protein levels of CYP1A1 and CYP1B1 levels were significantly elevated in CCSP-positive cell cultures. Benzo(a)pyrene 0-3 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 49-55 16227674-7 2005 Altered metabolism of benzo(a)pyrene due to the polymorphism in the CYP1A1 gene might be an etiologic factor in the increased incidence of AA in these patients. Benzo(a)pyrene 22-36 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 68-74 15867368-8 2005 Forced expression of CYP1A1wt or CYP1A1v in HOSE cells resulted in nuclear localization of the enzyme and acquisition of anchorage-independent growth, which was further exacerbated following exposure to benzo(a)pyrene or 17beta-estradiol. Benzo(a)pyrene 203-217 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 15867368-8 2005 Forced expression of CYP1A1wt or CYP1A1v in HOSE cells resulted in nuclear localization of the enzyme and acquisition of anchorage-independent growth, which was further exacerbated following exposure to benzo(a)pyrene or 17beta-estradiol. Benzo(a)pyrene 203-217 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 33-40 15637092-4 2005 The biological relevance of B[a]P and 7,8-diol-B[a]P redistribution by antibody was demonstrated by reversion of B[a]P-induced inhibition of proliferation of human peripheral blood lymphocytes and by inhibition of CYP 1A1 induction in HepG2 cells. Benzo(a)pyrene 28-33 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 214-221 15637092-4 2005 The biological relevance of B[a]P and 7,8-diol-B[a]P redistribution by antibody was demonstrated by reversion of B[a]P-induced inhibition of proliferation of human peripheral blood lymphocytes and by inhibition of CYP 1A1 induction in HepG2 cells. Benzo(a)pyrene 47-52 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 214-221 15735009-5 2005 Increase in expression of cytochrome P450 (CYP) genes was observed in response to BP exposure (CYP1A1 and CYP1B1; signal log ratio of 4.7 and 2.5, respectively). Benzo(a)pyrene 82-84 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 95-101 16218752-1 2005 Cytochrome P450 1A1 oxidizes a diverse range of substrates, including the procarcinogenic xenobiotic benzo[a]pyrene (B[a]P) and endogenous fatty acid precursors of prostaglandins, such as arachidonic acid (AA) and eicosapentaenoic acid (EA). Benzo(a)pyrene 101-115 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 16218752-1 2005 Cytochrome P450 1A1 oxidizes a diverse range of substrates, including the procarcinogenic xenobiotic benzo[a]pyrene (B[a]P) and endogenous fatty acid precursors of prostaglandins, such as arachidonic acid (AA) and eicosapentaenoic acid (EA). Benzo(a)pyrene 117-122 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 16162842-5 2005 Induction of CYP1A1 and CYP1B1 protein expression was observed by immunoblots in cells treated with BP alone or in co-treatments of SRM 1649a and BP or DBP. Benzo(a)pyrene 100-102 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-19 16162842-5 2005 Induction of CYP1A1 and CYP1B1 protein expression was observed by immunoblots in cells treated with BP alone or in co-treatments of SRM 1649a and BP or DBP. Benzo(a)pyrene 146-148 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-19 15905203-1 2005 The roles of CYP1A1 and 1B1 in tobacco smoke carcinogen, e.g. benzo[a]pyrene (BaP), induced DNA binding and their inhibition by the dietary polyphenol 5,7-dimethoxyflavone (DMF), compared with 3",4"-dimethoxyflavone (3",4"-DMF) and resveratrol, were investigated in the human oral epithelial squamous cell carcinoma (SCC)-9 cells. Benzo(a)pyrene 62-76 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-19 15905203-1 2005 The roles of CYP1A1 and 1B1 in tobacco smoke carcinogen, e.g. benzo[a]pyrene (BaP), induced DNA binding and their inhibition by the dietary polyphenol 5,7-dimethoxyflavone (DMF), compared with 3",4"-dimethoxyflavone (3",4"-DMF) and resveratrol, were investigated in the human oral epithelial squamous cell carcinoma (SCC)-9 cells. Benzo(a)pyrene 78-81 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-19 15905203-2 2005 A low concentration of BaP (1 microM) dramatically induced BaP-DNA adduct formation (approximately 40-fold) in a time-dependent manner, while it only increased CYP1A1/1B1 activities, as measured by ethoxyresorufin O-deethylation, approximately 3-fold. Benzo(a)pyrene 23-26 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 160-170 15905203-3 2005 Furthermore, BaP induced both CYP1B1 and CYP1A1 mRNA and protein expression, as determined by the branched DNA assay and western blot analysis, but with considerably higher levels of CYP1B1. Benzo(a)pyrene 13-16 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 41-47 15890477-6 2005 In summary, our study shows that the induction of both CYP1A1 and CYP1B1 resulted in an accelerated metabolism and an enhanced clearance of the potent procarcinogen BP, indicating that flavone, indole-3-carbinol and oltipraz have an impact on the biochemical barrier against BP in intestinal cells. Benzo(a)pyrene 165-167 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 55-61 15890477-6 2005 In summary, our study shows that the induction of both CYP1A1 and CYP1B1 resulted in an accelerated metabolism and an enhanced clearance of the potent procarcinogen BP, indicating that flavone, indole-3-carbinol and oltipraz have an impact on the biochemical barrier against BP in intestinal cells. Benzo(a)pyrene 275-277 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 55-61 15808407-0 2005 Induction of CYP1A1 and CYP1B1 and formation of carcinogen-DNA adducts in normal human mammary epithelial cells treated with benzo[a]pyrene. Benzo(a)pyrene 125-139 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-19 15808407-7 2005 On a per-person basis, CYP1A1 and CYP1B1 induction were well-correlated (r=0.88, P<0.001), which is to be expected as they are under the control of a common transcriptional regulation mechanism in response to BP exposure. Benzo(a)pyrene 212-214 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 23-29 15661813-4 2005 BaP also dramatically induced CYP1A1 activity, protein expression and mRNA levels, the likely reason for the marked increase in DNA binding. Benzo(a)pyrene 0-3 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 30-36 15661813-9 2005 DMF also inhibited BaP-induced CYP1A1 activity, CYP1A1 protein expression and mRNA levels. Benzo(a)pyrene 19-22 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 31-37 15661813-9 2005 DMF also inhibited BaP-induced CYP1A1 activity, CYP1A1 protein expression and mRNA levels. Benzo(a)pyrene 19-22 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 48-54 15661813-11 2005 In conclusion, DMF was a highly potent inhibitor of BaP-induced DNA binding and CYP1A1 protein expression and activity in the Hep G2 cells. Benzo(a)pyrene 52-55 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 80-86 15713371-2 2005 Benzo[a]pyrene (B[a]P) induces cytochrome P450 (CYP) 1A1, CYP1B1 and other xenobiotic metabolizing enzymes. Benzo(a)pyrene 0-14 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 31-56 15713371-2 2005 Benzo[a]pyrene (B[a]P) induces cytochrome P450 (CYP) 1A1, CYP1B1 and other xenobiotic metabolizing enzymes. Benzo(a)pyrene 16-21 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 31-56 15713371-5 2005 When co-treated with 1.0 microM TSA and BP, a reduction in the mRNA levels of both CYP1A1 and CYP1B1 was observed relative to BP alone. Benzo(a)pyrene 40-42 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 83-89 15713371-5 2005 When co-treated with 1.0 microM TSA and BP, a reduction in the mRNA levels of both CYP1A1 and CYP1B1 was observed relative to BP alone. Benzo(a)pyrene 126-128 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 83-89 15081398-4 2004 Such deleterious effects were associated with BP metabolite production, whose inhibition by the cytochrome P-450 1A1 inhibitor alpha-naphthoflavone fully abolished BP toxicity. Benzo(a)pyrene 46-48 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 96-116 15618000-0 2005 CYP1A1 genotype-selective inhibition of benzo[a]pyrene activation by quercetin. Benzo(a)pyrene 40-54 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 15261788-3 2004 For cell-line validation, our results demonstrated a dose-dependent increase in the Ah receptor-mediated response (i.e., CYP1A1 mRNA and EROD) of the cells upon exposure to a number of known Ah receptor agonists, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,7,8-tetrachlorodibenzothiophene, benzo[a]pyrene, and beta-naphthaflavone. Benzo(a)pyrene 304-318 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 121-127 15150120-6 2004 According to an aryl hydrocarbon hydroxylase enzyme activity assay, GNMT inhibited BaP-induced cytochrome P450 1A1 enzyme activity. Benzo(a)pyrene 83-86 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 95-114 15081870-1 2004 We examined the effects of amiloride derivatives, especially 5-(N-ethyl-N-isopropyl)amiloride (EIPA), on the activity of cytochrome P450 (CYP) 1 isoforms, known to metabolize carcinogenic polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BP), into mutagenic metabolites and whose cellular expression can be induced through interaction of PAHs with the arylhydrocarbon receptor. Benzo(a)pyrene 237-251 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 121-144 15081870-1 2004 We examined the effects of amiloride derivatives, especially 5-(N-ethyl-N-isopropyl)amiloride (EIPA), on the activity of cytochrome P450 (CYP) 1 isoforms, known to metabolize carcinogenic polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BP), into mutagenic metabolites and whose cellular expression can be induced through interaction of PAHs with the arylhydrocarbon receptor. Benzo(a)pyrene 253-255 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 121-144 15081870-5 2004 Inhibition of CYP1 activity by EIPA was associated with a decreased metabolism of BP, a reduced formation of BP-derived DNA adducts and a diminished BP-induced apoptosis in liver cells. Benzo(a)pyrene 82-84 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-18 15081870-5 2004 Inhibition of CYP1 activity by EIPA was associated with a decreased metabolism of BP, a reduced formation of BP-derived DNA adducts and a diminished BP-induced apoptosis in liver cells. Benzo(a)pyrene 109-111 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-18 15081870-5 2004 Inhibition of CYP1 activity by EIPA was associated with a decreased metabolism of BP, a reduced formation of BP-derived DNA adducts and a diminished BP-induced apoptosis in liver cells. Benzo(a)pyrene 109-111 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-18 15081398-4 2004 Such deleterious effects were associated with BP metabolite production, whose inhibition by the cytochrome P-450 1A1 inhibitor alpha-naphthoflavone fully abolished BP toxicity. Benzo(a)pyrene 164-166 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 96-116 14729370-7 2004 With regard to the proposal that BaP may be activated by human CYP1A1, our results suggest that the nitrogen-substitution at position-10 of BaP may cause the CYP enzyme-specificity in metabolic activation to change from CYP1A1 to CYP1A2. Benzo(a)pyrene 33-36 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 63-69 14729370-7 2004 With regard to the proposal that BaP may be activated by human CYP1A1, our results suggest that the nitrogen-substitution at position-10 of BaP may cause the CYP enzyme-specificity in metabolic activation to change from CYP1A1 to CYP1A2. Benzo(a)pyrene 33-36 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 220-226 14729370-7 2004 With regard to the proposal that BaP may be activated by human CYP1A1, our results suggest that the nitrogen-substitution at position-10 of BaP may cause the CYP enzyme-specificity in metabolic activation to change from CYP1A1 to CYP1A2. Benzo(a)pyrene 140-143 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 63-69 14729370-7 2004 With regard to the proposal that BaP may be activated by human CYP1A1, our results suggest that the nitrogen-substitution at position-10 of BaP may cause the CYP enzyme-specificity in metabolic activation to change from CYP1A1 to CYP1A2. Benzo(a)pyrene 140-143 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 220-226 14743400-1 2004 Constitutive and benzo[a]pyrene (B[a]P) inducible expression of CYP1A1 and CYP1A2 in prostate cancer and normal prostate epithelial cells were examined by immunoblotting. Benzo(a)pyrene 17-31 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 64-70 14743400-6 2004 Treatment with 4 microM B[a]P induced CYP1A1 expression in both normal and primary tumor prostate cells. Benzo(a)pyrene 24-29 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 38-44 12507920-0 2002 CYP1A1 and GSTM1 genotypes affect benzo[a]pyrene DNA adducts in smokers" lung: comparison with aromatic/hydrophobic adduct formation. Benzo(a)pyrene 34-48 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 14761401-0 2003 [The expression of cytochrome P450 1A1 of endothelial cells induced by benzo(a)pyrene]. Benzo(a)pyrene 71-85 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 19-38 14761401-1 2003 OBJECTIVE: To explore the effect of benzo(a)pyrene (BaP) on the expression and the activities of cytochrome P450 1A1 (CYP1A1) of porcine aortic endothelial cells. Benzo(a)pyrene 36-50 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 97-116 14761401-1 2003 OBJECTIVE: To explore the effect of benzo(a)pyrene (BaP) on the expression and the activities of cytochrome P450 1A1 (CYP1A1) of porcine aortic endothelial cells. Benzo(a)pyrene 36-50 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 118-124 14761401-1 2003 OBJECTIVE: To explore the effect of benzo(a)pyrene (BaP) on the expression and the activities of cytochrome P450 1A1 (CYP1A1) of porcine aortic endothelial cells. Benzo(a)pyrene 52-55 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 97-116 14761401-1 2003 OBJECTIVE: To explore the effect of benzo(a)pyrene (BaP) on the expression and the activities of cytochrome P450 1A1 (CYP1A1) of porcine aortic endothelial cells. Benzo(a)pyrene 52-55 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 118-124 14761401-4 2003 RESULTS: By Western blot, the expression of CYP1A1 of control cells was not found, but the expression of CYP1A1 of cells treated with BaP was found; By immunohistochemistry, only part of endothelial cells treated with BaP had positive expression of CYP1A1. Benzo(a)pyrene 134-137 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 105-111 14761401-4 2003 RESULTS: By Western blot, the expression of CYP1A1 of control cells was not found, but the expression of CYP1A1 of cells treated with BaP was found; By immunohistochemistry, only part of endothelial cells treated with BaP had positive expression of CYP1A1. Benzo(a)pyrene 134-137 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 105-111 14761401-4 2003 RESULTS: By Western blot, the expression of CYP1A1 of control cells was not found, but the expression of CYP1A1 of cells treated with BaP was found; By immunohistochemistry, only part of endothelial cells treated with BaP had positive expression of CYP1A1. Benzo(a)pyrene 218-221 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 105-111 14761401-4 2003 RESULTS: By Western blot, the expression of CYP1A1 of control cells was not found, but the expression of CYP1A1 of cells treated with BaP was found; By immunohistochemistry, only part of endothelial cells treated with BaP had positive expression of CYP1A1. Benzo(a)pyrene 218-221 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 105-111 14761401-6 2003 CONCLUSION: BaP could induce part of endothelial cells to synthesize CYP1A1. Benzo(a)pyrene 12-15 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 69-75 12670496-3 2003 We compared the effects of 11 representative natural polyphenols, which normally occur in food, on different activities of CYP1A1, namely epoxidation of 7,8-dihydrodiol-benzo[a]pyrene, the terminal step in the activation leading to the ultimate carcinogenic diolepoxides, hydroxylation of benzo[a]pyrene, and EROD. Benzo(a)pyrene 169-183 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 123-129 12641979-3 2002 Also, the effects of chrysotile on the activities of CYP1A1 and GST induced by benzo(a)pyrene were studied. Benzo(a)pyrene 79-93 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-59 11513080-6 2001 Expression of CYP 1A1 and 1A2 messenger ribonucleic acid by the cells was induced by treatment with benz[a]pyrene, 3-methylcholanthrene, and benz[a]anthracene. Benzo(a)pyrene 100-113 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-21 12127040-0 2002 Benzo(a)pyrene exposure induces CYP1A1 activity and expression in human endometrial cells. Benzo(a)pyrene 0-14 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 32-38 12127040-3 2002 The objective of this research was to investigate effects of cigarette smoke related hydrocarbons (benzo(a)pyrene, BP) on uterine CYP1A1/2 and 1B1, enzymes involved in estrogen metabolism. Benzo(a)pyrene 99-113 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 130-146 12127040-3 2002 The objective of this research was to investigate effects of cigarette smoke related hydrocarbons (benzo(a)pyrene, BP) on uterine CYP1A1/2 and 1B1, enzymes involved in estrogen metabolism. Benzo(a)pyrene 115-117 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 130-146 12127040-9 2002 Low level of constitutive CYP1 activity was observed in RL95-2 cells, which was significantly induced by BP exposure (12-fold at 1mM). Benzo(a)pyrene 105-107 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 26-30 12127040-10 2002 CYP1 activity in BP-induced cells was significantly inhibited by specific anti-CYP1A1 and high concentration of alpha-naphthoflavone (ANF, 100nM), but not by selective CYP1A2 (furafylline) and CYP1B1 (homoeriodictoyl) inhibitors and low concentration of ANF (5nM). Benzo(a)pyrene 17-19 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-4 12127040-10 2002 CYP1 activity in BP-induced cells was significantly inhibited by specific anti-CYP1A1 and high concentration of alpha-naphthoflavone (ANF, 100nM), but not by selective CYP1A2 (furafylline) and CYP1B1 (homoeriodictoyl) inhibitors and low concentration of ANF (5nM). Benzo(a)pyrene 17-19 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 79-85 11849738-2 2002 CYP1A1 transcripts were present in all of the lung specimens and were induced by the prototypic inducers 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo[a]pyrene (B[a]P), and by the atypical inducers pyridine, nicotine, and omeprazole. Benzo(a)pyrene 152-166 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 11952781-2 2002 Human cytochrome P4501A1 (CYP1A1) is one of the key enzymes in the bioactivation of environmental pollutants such as benzo[a]pyrene (B[a]P) and other polycyclic aromatic hydrocarbons. Benzo(a)pyrene 117-131 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 6-24 11952781-2 2002 Human cytochrome P4501A1 (CYP1A1) is one of the key enzymes in the bioactivation of environmental pollutants such as benzo[a]pyrene (B[a]P) and other polycyclic aromatic hydrocarbons. Benzo(a)pyrene 117-131 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 26-32 11854143-0 2002 Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite. Benzo(a)pyrene 69-83 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-19 11854143-2 2002 We examined the effects of NaAsO(2) in combination with benzo[a]pyrene (BAP) on CYP1A1 and CYP1B1 in T-47D human breast cancer cells by using estrogen metabolism as a probe of their activities. Benzo(a)pyrene 56-70 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 80-86 11921196-7 2002 Interestingly, endogenous 17beta-estradiol (E(2)) is metabolized by the cytochrome P450 enzyme isoforms CYP1A1 and CYP1B1, which also activate benzo[a]pyrene (B[a]P), a carcinogen contained in cigarette smoke. Benzo(a)pyrene 143-157 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 104-110 11485833-5 2001 S(9) fractions from the tissues catalyzed the bioactivation of benzo[a]pyrene (B[a]P), a CYP1A1-preferential activity, to mutagens in the Ames assay. Benzo(a)pyrene 63-77 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 89-95 11468695-3 2001 The tumor susceptibility gene P-450 1A1 (CYP1A1) is involved in the activation of polycyclic aromatic hydrocarbons, including benzo[a]pyrene, producing DNA-damaging epoxides that lead to G:C-->T:A point mutations. Benzo(a)pyrene 126-140 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 41-47 12127040-12 2002 It also appears that CYP1A1 is one of the major CYP450 enzymes induced by BP. Benzo(a)pyrene 74-76 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 11754570-6 2002 Furthermore, when HepG2 cells were pretreated with omeprazole to induce CYP1A1, then exposed to benzo[a]pyrene (B[a]P), DNA damage was observed using the comet assay. Benzo(a)pyrene 96-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 72-78 11752233-5 2002 Likewise, DNA damage (SB and DNA adducts) was elevated in V79 h1A1-MZ cells expressing human CYP1A1 when treated with BaP (0.1-0.5 microM) and this was inhibited by chrysin and apigenin, but not by quercetin. Benzo(a)pyrene 118-121 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 93-99 11564581-14 2001 The risk of CYP1A1 can be supported by the functional difference between presence of valine and isoleucine; valine type has higher catalytic and mutagenic activity towards benzo[a] pyrene than the isoleucine type. Benzo(a)pyrene 172-187 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 12-18 11513247-10 2001 All three CYP1A1 variants were active in metabolizing the precarcinogen benzo[a]pyrene (B[a]P), with wild-type enzyme showing the highest activity, followed by CYP1A1.4 (60%) and CYP1A1.2 (40%). Benzo(a)pyrene 72-86 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 10-16 11513247-10 2001 All three CYP1A1 variants were active in metabolizing the precarcinogen benzo[a]pyrene (B[a]P), with wild-type enzyme showing the highest activity, followed by CYP1A1.4 (60%) and CYP1A1.2 (40%). Benzo(a)pyrene 72-86 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 160-166 11513247-10 2001 All three CYP1A1 variants were active in metabolizing the precarcinogen benzo[a]pyrene (B[a]P), with wild-type enzyme showing the highest activity, followed by CYP1A1.4 (60%) and CYP1A1.2 (40%). Benzo(a)pyrene 72-86 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 160-166 11238186-0 2001 Differential metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 variants. Benzo(a)pyrene 27-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 86-92 11166912-5 2001 S9 fractions from the tissues catalyzed the bioactivation of benzo[a]pyrene (B[a]P), a CYP1A1-preferential activity, to mutagens in the Ames assay. Benzo(a)pyrene 61-75 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 87-93 11239493-3 2001 The CYP1A1 gene is highly inducible by the environmental contaminants dioxin and benzo[a]pyrene. Benzo(a)pyrene 81-95 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-10 11238186-1 2001 Cytochrome P450 1A1 (CYP1A1) plays a key role in the metabolism of carcinogens, such as benzo[a]pyrene (B[a]P) and metabolites to ultimate carcinogens. Benzo(a)pyrene 88-102 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 11238186-1 2001 Cytochrome P450 1A1 (CYP1A1) plays a key role in the metabolism of carcinogens, such as benzo[a]pyrene (B[a]P) and metabolites to ultimate carcinogens. Benzo(a)pyrene 88-102 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 10597900-3 1999 This inhibition is correlated with the capacity of the isoflavones to prevent CYP1A1-mediated covalent binding of benzo[a]pyrene (BaP) metabolites to DNA. Benzo(a)pyrene 114-128 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 78-84 11162773-2 2001 The effect of As, Pb, Hg, or Cd (ranked as the most hazardous environmental metals by EPA and ATSDR) on CYP1A1 and 1A2 induction by benzo[a]pyrene (BaP), benzo[b]fluoranthene (BbF), dibenzo[a,h]anthracene (DBahA), benzo[a]anthracene (BaA), and benzo[k]fluoranthene (BkF) has thus been investigated in fresh human hepatocyte cultures. Benzo(a)pyrene 132-146 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 104-110 11162773-2 2001 The effect of As, Pb, Hg, or Cd (ranked as the most hazardous environmental metals by EPA and ATSDR) on CYP1A1 and 1A2 induction by benzo[a]pyrene (BaP), benzo[b]fluoranthene (BbF), dibenzo[a,h]anthracene (DBahA), benzo[a]anthracene (BaA), and benzo[k]fluoranthene (BkF) has thus been investigated in fresh human hepatocyte cultures. Benzo(a)pyrene 148-151 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 104-110 11141357-0 2001 Benzo[g,h,i]perylene synergistically transactivates benzo[a]pyrene-induced CYP1A1 gene expression by aryl hydrocarbon receptor pathway. Benzo(a)pyrene 52-66 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 75-81 11141357-6 2001 Our previous report showed that cytochrome P450 1A1 (CYP1A1) is responsible for the metabolic activation of BaP and the formation of B[a]P adduct in HepG2 cells. Benzo(a)pyrene 108-111 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 32-51 11141357-6 2001 Our previous report showed that cytochrome P450 1A1 (CYP1A1) is responsible for the metabolic activation of BaP and the formation of B[a]P adduct in HepG2 cells. Benzo(a)pyrene 108-111 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-59 11141357-7 2001 Western blot and Northern blot analyses were used to evaluate whether BaP-induced CYP1A1 protein and mRNA levels increased following the addition of BghiP. Benzo(a)pyrene 70-73 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 82-88 11141357-8 2001 Our data showed that BghiP enhanced BaP-induced CYP1A1 protein and its mRNA levels. Benzo(a)pyrene 36-39 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 48-54 11141357-9 2001 To understand whether BghiP enhances BaP-induced CYP1A1 gene expression through the aryl hydrocarbon receptor (AhR) signaling pathway, a gel retardation assay was performed to elucidate the synergistic mechanism of BghiP in BaP-induced CYP1A1 gene expression. Benzo(a)pyrene 37-40 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 49-55 11141357-12 2001 Our findings demonstrated that BghiP enhances BaP-induced CYP1A1 transcription by AhR activation and suggested that the induction mechanism of CYP1A1 contributes to the cocarcinogenic potential of BghiP in BaP-induced carcinogenesis. Benzo(a)pyrene 46-49 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 58-64 11141357-12 2001 Our findings demonstrated that BghiP enhances BaP-induced CYP1A1 transcription by AhR activation and suggested that the induction mechanism of CYP1A1 contributes to the cocarcinogenic potential of BghiP in BaP-induced carcinogenesis. Benzo(a)pyrene 46-49 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 143-149 11141357-12 2001 Our findings demonstrated that BghiP enhances BaP-induced CYP1A1 transcription by AhR activation and suggested that the induction mechanism of CYP1A1 contributes to the cocarcinogenic potential of BghiP in BaP-induced carcinogenesis. Benzo(a)pyrene 206-209 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 58-64 11141357-12 2001 Our findings demonstrated that BghiP enhances BaP-induced CYP1A1 transcription by AhR activation and suggested that the induction mechanism of CYP1A1 contributes to the cocarcinogenic potential of BghiP in BaP-induced carcinogenesis. Benzo(a)pyrene 206-209 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 143-149 11162432-5 2000 In vitro and whole-cell metabolic activity studies showed that the periplasmically-located CYP1A1 competently catalysed NADPH-dependent benzo[a]pyrene 3-hydroxylation and 7-ethoxyresorufin O-deethylation. Benzo(a)pyrene 136-150 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 91-97 10597900-3 1999 This inhibition is correlated with the capacity of the isoflavones to prevent CYP1A1-mediated covalent binding of benzo[a]pyrene (BaP) metabolites to DNA. Benzo(a)pyrene 130-133 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 78-84 10597900-7 1999 Daidzein and genistein non-competitive with the CYP1A1 substrate BaP for microsomal BaP hydroxylation, with apparent Ki values of 325 microM and 140 microM, respectively. Benzo(a)pyrene 65-68 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 48-54 10597900-7 1999 Daidzein and genistein non-competitive with the CYP1A1 substrate BaP for microsomal BaP hydroxylation, with apparent Ki values of 325 microM and 140 microM, respectively. Benzo(a)pyrene 84-87 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 48-54 9631944-2 1998 Microsomal CYP1A1 activity in renal cell carcinoma (RCC) and in normal renal tissue was determined by measuring spectrofluorometrically the hydroxylation rate of benzo[a]pyrene. Benzo(a)pyrene 162-176 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 11-17 10693172-0 1999 Quercetin inhibits benzo[a]pyrene-induced DNA adducts in human Hep G2 cells by altering cytochrome P-450 1A1 gene expression. Benzo(a)pyrene 19-33 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 88-108 9731718-1 1998 Because aryl hydrocarbon hydroxylase (AHH) is considered to be responsible for the activation of benzo(a)pyrene and other polyaromatic hydrocarbons in cigarette smoke to carcinogens, it is important to examine CYP1A1 (AHH) activity in the determination of susceptibility to lung cancer. Benzo(a)pyrene 97-111 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 8-36 9731718-1 1998 Because aryl hydrocarbon hydroxylase (AHH) is considered to be responsible for the activation of benzo(a)pyrene and other polyaromatic hydrocarbons in cigarette smoke to carcinogens, it is important to examine CYP1A1 (AHH) activity in the determination of susceptibility to lung cancer. Benzo(a)pyrene 97-111 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 38-41 10496959-4 1999 Resveratrol inhibited the B[a]P-induced expression of the CYP1A1 gene, as measured at the mRNA and transcriptional levels. Benzo(a)pyrene 26-31 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 58-64 10331078-1 1999 Cytochrome P4501A1 is a substrate-inducible microsomal enzyme that oxygenates polycyclic aromatic hydrocarbons, such as the carcinogen benzo(a)pyrene, as the initial step in their metabolic processing to water-soluble derivatives. Benzo(a)pyrene 135-149 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-18 8759031-4 1996 Exposure of cultured GMCs to BaP (30 microM) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 10 nM) for 24 hr induced CYP1A1 mRNA levels, a response abolished by cotreatment with 10 microM cycloheximide. Benzo(a)pyrene 29-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 116-122 21528215-1 1997 Cytochrome p4501A1 gene (CYP1A1) and glutathione S-transferase mu gene (GSTM1) are involved in the metabolic activation or detoxification of environmental carcinogens including benzo[a]pyrene in tobacco smoke. Benzo(a)pyrene 177-191 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 25-31 8759031-1 1996 Evidence for CYP1A1 and CYP1B1 expression and their involvement in benzo[a]pyrene metabolism. Benzo(a)pyrene 67-81 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-19 9465551-1 1997 Since aryl hydrocarbon hydroxylase (AHH) is considered to be responsible for the activation of benzo(a)pyrene (BP) and other polyaromatic hydrocarbons in cigarette smoke to carcinogens, it is important to examine AHH activity in the determination of susceptibility to lung cancer. Benzo(a)pyrene 95-109 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 6-34 9465551-1 1997 Since aryl hydrocarbon hydroxylase (AHH) is considered to be responsible for the activation of benzo(a)pyrene (BP) and other polyaromatic hydrocarbons in cigarette smoke to carcinogens, it is important to examine AHH activity in the determination of susceptibility to lung cancer. Benzo(a)pyrene 111-113 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 6-34 9070231-3 1997 TCDD and BaP both showed induction of cytochrome P450 1A1 (CYP1A1), whereas only BaP caused a significant loss of EGFRs. Benzo(a)pyrene 9-12 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 38-57 9070231-3 1997 TCDD and BaP both showed induction of cytochrome P450 1A1 (CYP1A1), whereas only BaP caused a significant loss of EGFRs. Benzo(a)pyrene 9-12 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 59-65 8759031-5 1996 The pattern of hydrocarbon inducibility was atypical in that BaP was a more effective inducer of CYP1A1 gene expression than TCDD, and both hydrocarbons induced aryl hydrocarbon hydroxylase (AHH) activity, but not ethoxyresorufin-O-deethylase activity. Benzo(a)pyrene 61-64 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 97-103 8759031-5 1996 The pattern of hydrocarbon inducibility was atypical in that BaP was a more effective inducer of CYP1A1 gene expression than TCDD, and both hydrocarbons induced aryl hydrocarbon hydroxylase (AHH) activity, but not ethoxyresorufin-O-deethylase activity. Benzo(a)pyrene 61-64 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 191-194 8759031-6 1996 Cotreatment with alpha-naphthoflavone (alpha NF, 1 microM) or ellipticine (ELLIP, 0.1 nM) only partially inhibited the induction of AHH activity by BaP (30 microM). Benzo(a)pyrene 148-151 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 132-135 8759031-9 1996 These results demonstrate that CYP1A1 and CYP1B1-related activities are induced in GMCs by BaP and TCDD and this induction is associated with metabolism of BaP to reactive intermediates that bind covalently to DNA. Benzo(a)pyrene 91-94 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 31-37 8759031-9 1996 These results demonstrate that CYP1A1 and CYP1B1-related activities are induced in GMCs by BaP and TCDD and this induction is associated with metabolism of BaP to reactive intermediates that bind covalently to DNA. Benzo(a)pyrene 156-159 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 31-37 7591186-2 1995 Because CYP1A1 catalyzes bioactivation of environmental procarcinogens, such as benzo[a]pyrene, it is very important to study the clinical meaning of Ile-Val polymorphism using an epidemiological study. Benzo(a)pyrene 80-94 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 8-14 7671346-3 1995 The human hepatoma cell line, HepG2, was used to examine the effect of inhibition of CYP1A1 activity by anti CYP1A1 specific antibodies on BaP metabolism. Benzo(a)pyrene 139-142 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 85-91 7587956-7 1995 The enzyme metabolized substrates characteristic for CYP1A1:benzo[a]pyrene (4.0 +/- 0.3 nmol/min/nmol CYP), 7-ethoxy-4-trifluoromethyl- coumarin (36 +/- 2), ethoxyresorufin (37 +/- 1), but not pentoxyresorufin (0.77 +/- 0.02). Benzo(a)pyrene 60-74 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-59 8706015-1 1996 CYP1A1 is responsible for the metabolic activation of benzo(a)pyrene in cigarette smoke, and high susceptibility to smoking-related lung cancer has been associated with the MspI polymorphism of the CYP1A1 gene. Benzo(a)pyrene 54-68 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 8706015-1 1996 CYP1A1 is responsible for the metabolic activation of benzo(a)pyrene in cigarette smoke, and high susceptibility to smoking-related lung cancer has been associated with the MspI polymorphism of the CYP1A1 gene. Benzo(a)pyrene 54-68 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 198-204 8625448-2 1996 Ellagic acid has been shown to inhibit the CYP1A1-dependent activation of benzo[a]pyrene; to bind to and detoxify the diolepoxide of benzo[a]pyrene; to bind to DNA and reduce the formation of O6-methylguanine by methylating carcinogens; and to induce the phase II detoxification enzymes glutathione S-transferase Ya and NAD(P)H:quinone reductase. Benzo(a)pyrene 74-88 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 43-49 8625448-2 1996 Ellagic acid has been shown to inhibit the CYP1A1-dependent activation of benzo[a]pyrene; to bind to and detoxify the diolepoxide of benzo[a]pyrene; to bind to DNA and reduce the formation of O6-methylguanine by methylating carcinogens; and to induce the phase II detoxification enzymes glutathione S-transferase Ya and NAD(P)H:quinone reductase. Benzo(a)pyrene 133-147 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 43-49 8729008-2 1996 One of these hemoproteins, cytochrome P4501A1, is most closely associated with the bioactivation of polycyclic aromatic hydrocarbons such as benzo[a]pyrene, which may play a role in environmental carcinogenesis. Benzo(a)pyrene 141-155 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 27-45 7488231-8 1995 Finally, cytochrome P450 1A1 (CYP1A1) was induced in a concentration-dependent manner by BaP in both cell lines. Benzo(a)pyrene 89-92 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 9-28 7488231-8 1995 Finally, cytochrome P450 1A1 (CYP1A1) was induced in a concentration-dependent manner by BaP in both cell lines. Benzo(a)pyrene 89-92 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 30-36 7671346-4 1995 Metabolism of BaP to water-soluble metabolites by HepG2 cells in culture was 50% lower in fluorescein isothiocyanate (FITC)-insulin-CYP1A1-antibody-conjugate-treated cells than in control cells. Benzo(a)pyrene 14-17 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 132-138 7556107-15 1995 The cytogenetic data are consistent, first-off, with reports that individuals in the population vary widely with respect to the inducibility of the CYP1A1 gene, which is known to be involved in polycyclic aromatic hydrocarbon metabolism, in particular, in BaP. Benzo(a)pyrene 256-259 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 148-154 7581497-2 1995 Here, the application of rat and human CYP1A1 and CYP1A2 is demonstrated for comparative studies on the oxidation of polycyclic aromatic hydrocarbons, such as phenanthrene, benz[a]anthracene, and benzo[a]pyrene. Benzo(a)pyrene 196-210 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 39-45 7581497-8 1995 Benzo[a]pyrene was twice as cytotoxic in the human cytochrome P450 1A1 than in the rat cytochrome P450 1A1 expressing V79 cells. Benzo(a)pyrene 0-14 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 51-70 7581497-6 1995 Most important was the finding, that human cytochrome P450 1A1 almost exclusively oxidized benzo[a]pyrene in the 7,8,9,10-position, yielding the ultimate carcinogen 7,8-dihydroxy-9,10-epoxy-7,8,9, 10-tetrahydrobenzo[a]pyrene whereas the rat cytochrome P450 1A1 oxidized benzo[]pyrene in the 4,5-position and 7,8,9,10-position. Benzo(a)pyrene 91-105 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 43-62 1906275-1 1991 Fluorescence quenching of benzo[a]pyrene (BP) by cytochrome P450c was used to probe this substrate-enzyme binding interaction. Benzo(a)pyrene 26-40 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 49-65 7923575-1 1994 Cytochrome P450 1A1 (CYP1A1) activity is associated with increased susceptibility to lung cancer induced by polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BP). Benzo(a)pyrene 149-163 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 7923575-1 1994 Cytochrome P450 1A1 (CYP1A1) activity is associated with increased susceptibility to lung cancer induced by polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BP). Benzo(a)pyrene 149-163 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 7923575-1 1994 Cytochrome P450 1A1 (CYP1A1) activity is associated with increased susceptibility to lung cancer induced by polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BP). Benzo(a)pyrene 165-167 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 7923575-1 1994 Cytochrome P450 1A1 (CYP1A1) activity is associated with increased susceptibility to lung cancer induced by polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BP). Benzo(a)pyrene 165-167 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 7923575-2 1994 In non-hepatic human tissues, CYP1A1 is the principal enzyme responsible for the metabolic activation of the proximate BP mutagenic metabolite, (-)-benzo[a]pyrene-trans-7,8-dihydrodiol, to (+)-anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide, the ultimate BP mutagen. Benzo(a)pyrene 119-121 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 30-36 7923575-2 1994 In non-hepatic human tissues, CYP1A1 is the principal enzyme responsible for the metabolic activation of the proximate BP mutagenic metabolite, (-)-benzo[a]pyrene-trans-7,8-dihydrodiol, to (+)-anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide, the ultimate BP mutagen. Benzo(a)pyrene 262-264 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 30-36 8160212-0 1994 Molecular modelling of cytochrome CYP1A1: a putative access channel explains differences in induction potency between the isomers benzo(a)pyrene and benzo(e)pyrene, and 2- and 4-acetylaminofluorene. Benzo(a)pyrene 130-144 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 34-40 7912124-2 1994 Cytochrome P-4501A1 (CYP1A1) metabolically activates precarcinogens in cigarette smoke, such as benzo(a)pyrene, which is also an inducer of CYP1A1. Benzo(a)pyrene 96-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 7912124-2 1994 Cytochrome P-4501A1 (CYP1A1) metabolically activates precarcinogens in cigarette smoke, such as benzo(a)pyrene, which is also an inducer of CYP1A1. Benzo(a)pyrene 96-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 7912124-2 1994 Cytochrome P-4501A1 (CYP1A1) metabolically activates precarcinogens in cigarette smoke, such as benzo(a)pyrene, which is also an inducer of CYP1A1. Benzo(a)pyrene 96-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 140-146 8126925-7 1994 Since AHH is also responsible for the activation to carcinogens of benzo (a)pyrene and other aromatic hydrocarbons in cigarette smoke, it may also be important in humans in the causation of lung cancer. Benzo(a)pyrene 67-82 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 6-9 8222045-3 1993 Many polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene, and chlorinated PAH such as polychlorinated dibenzodioxins, dibenzofurans and biphenyls induce CYP1A1 expression through activation of an endogenous protein, the Ah receptor. Benzo(a)pyrene 52-66 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 163-169 8293790-0 1993 Stable expression of human cytochrome P450 1A1 cDNA in V79 Chinese hamster cells and metabolic activation of benzo[a]pyrene. Benzo(a)pyrene 109-123 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 27-46 8353849-2 1993 In particular, cytochrome P450 1A1 (CYP1A1) catalyzes the conversion of polycyclic aromatic hydrocarbons, such as benzo[a]pyrene, into potent mutagenic agents. Benzo(a)pyrene 114-128 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 15-34 8353849-2 1993 In particular, cytochrome P450 1A1 (CYP1A1) catalyzes the conversion of polycyclic aromatic hydrocarbons, such as benzo[a]pyrene, into potent mutagenic agents. Benzo(a)pyrene 114-128 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-42 8353849-12 1993 These studies demonstrate the usefulness of the CYP1A1 transformed fibroblasts in examining the cytotoxic effects of benzo[a]pyrene metabolites and suggest the future usefulness in examining the toxic effects of polycyclic aromatic hydrocarbons and other xenobiotics bioactivated by CYP1A1. Benzo(a)pyrene 117-131 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 48-54 8225503-3 1993 Lung cancer patients who were recent smokers had significantly induced benzo[a]pyrene (BaP)-3-hydroxylase (AHH) and ethoxycoumarin O-deethylase activities in lung parenchyma compared with smoking non-cancer patients. Benzo(a)pyrene 71-85 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 107-110 8225503-3 1993 Lung cancer patients who were recent smokers had significantly induced benzo[a]pyrene (BaP)-3-hydroxylase (AHH) and ethoxycoumarin O-deethylase activities in lung parenchyma compared with smoking non-cancer patients. Benzo(a)pyrene 87-90 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 107-110 1316759-4 1992 In this study, we used the PAH isomers benzo[a]pyrene (BaP) and benzo[e]pyrene (BeP) to further evaluate the role of the 4S PAH-binding protein in induction of the CYP1A1 gene in H4-II-E rat hepatoma cells. Benzo(a)pyrene 39-53 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 164-170 8200084-7 1994 In contrast, benzo[a]pyrene was exclusively activated by CYP1A1 whereas CYP1A2 was inactive. Benzo(a)pyrene 13-27 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 57-63 8160212-1 1994 The present studies were undertaken to provide a rationale for the observation that benzo(a)pyrene and 2-acetylaminofluorene induce the hepatic CYP1A1 protein, whereas their non-carcinogenic isomers benzo(e)pyrene and 4-acetylaminofluorene are, at best, relatively very weak inducers. Benzo(a)pyrene 84-98 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 144-150 8482321-3 1993 Significant clastogenic effects were observed after an 18 h exposure to aflatoxin B1 and cyclophosphamide in CYP2B1 expressing cells, to benzo[a]pyrene in CYP1A1 and CYP1A2 expressing cells, to 7,12-dimethylbenz[a]anthracene and dimethylnitrosamine in cells, expressing CYP1A2 with or without acetyltransferase, and to cyclophosphamide in cells expressing both CYP1A2 and acetyltransferase. Benzo(a)pyrene 137-151 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 155-161 1516694-1 1992 Fluorescence quenching of benzo[a]pyrene (BP) by cytochrome P-450 1A1 was used to probe the effect of the lipid, dilauroyl-L-3-phosphatidylcholine, on this substrate-enzyme interaction. Benzo(a)pyrene 26-40 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 49-69 1516694-1 1992 Fluorescence quenching of benzo[a]pyrene (BP) by cytochrome P-450 1A1 was used to probe the effect of the lipid, dilauroyl-L-3-phosphatidylcholine, on this substrate-enzyme interaction. Benzo(a)pyrene 42-44 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 49-69 1906275-5 1991 Reductase had no effect in the presence of an anti-P450c monoclonal antibody which inhibits BP hydroxylation, which suggests that this monoclonal antibody binds P450c near its reductase binding region. Benzo(a)pyrene 92-94 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 161-166 1707592-1 1991 The human CYP1A1 (cytochrome P1450) gene encodes an enzyme involved in the activation of procarcinogens, such as benzo[a]pyrene, to the ultimate reactive intermediate. Benzo(a)pyrene 113-127 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 10-16 1906275-1 1991 Fluorescence quenching of benzo[a]pyrene (BP) by cytochrome P450c was used to probe this substrate-enzyme binding interaction. Benzo(a)pyrene 42-44 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 49-65 1906275-2 1991 Addition of NADPH-cytochrome P450 reductase, an essential electron carrier during P450 catalysis, resulted in increased quenching and thus strengthened binding of BP to P450c. Benzo(a)pyrene 163-165 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 169-174 1906275-5 1991 Reductase had no effect in the presence of an anti-P450c monoclonal antibody which inhibits BP hydroxylation, which suggests that this monoclonal antibody binds P450c near its reductase binding region. Benzo(a)pyrene 92-94 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 51-56 34360828-1 2021 The environmental pollutant benzo(a)pyrene (BaP) is a human carcinogen that reacts with DNA after metabolic activation catalysed by cytochromes P450 (CYP) 1A1 and 1B1 together with microsomal epoxide hydrolase. Benzo(a)pyrene 28-42 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 132-166 34360828-1 2021 The environmental pollutant benzo(a)pyrene (BaP) is a human carcinogen that reacts with DNA after metabolic activation catalysed by cytochromes P450 (CYP) 1A1 and 1B1 together with microsomal epoxide hydrolase. Benzo(a)pyrene 44-47 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 132-166 34439562-6 2021 Cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1) and Cytochrome P450 subfamily B polypeptide 1 (CYP1B1) downregulation resulting from decreased aryl hydrocarbon receptor (AhR) translocation into nuclei attenuated the effects of B(a)P-induced lipid accumulation and repressed cell viability, respectively. Benzo(a)pyrene 239-244 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-50 34439562-6 2021 Cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1) and Cytochrome P450 subfamily B polypeptide 1 (CYP1B1) downregulation resulting from decreased aryl hydrocarbon receptor (AhR) translocation into nuclei attenuated the effects of B(a)P-induced lipid accumulation and repressed cell viability, respectively. Benzo(a)pyrene 239-244 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 52-58