PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20466593-0 2010 Aryl hydrocarbon receptor antagonists attenuate the deleterious effects of benzo[a]pyrene on isolated rat follicle development. Benzo(a)pyrene 75-89 aryl hydrocarbon receptor Rattus norvegicus 0-25 22643862-5 2012 In further studies, it was demonstrated that R,S-sulforaphane could both prevent the interaction of and displace already bound benzo[a]pyrene from the Ah receptor, but no concentration dependency was observed with respect to the isothiocyanate. Benzo(a)pyrene 127-141 aryl hydrocarbon receptor Rattus norvegicus 151-162 22643862-7 2012 Of the two isomers of R,S-sulforaphane, the naturally occurring R-isomer was more effective than the S-isomer in antagonizing the activation of the Ah receptor by benzo[a]pyrene. Benzo(a)pyrene 163-177 aryl hydrocarbon receptor Rattus norvegicus 148-159 20848083-2 2011 BaP toxicity is mediated, in part, by activation of the aryl hydrocarbon receptor and formation of reactive metabolites, both of which lead to increased oxidative stress. Benzo(a)pyrene 0-3 aryl hydrocarbon receptor Rattus norvegicus 56-81 23026235-2 2012 AhR is ligand activated transcription factor with high affinities for aromatic planar compounds such as beta-naphthoflavone (BNF), 3-methylcholanthrene (3-MC), benzo[a]pyrene (BaP) or dioxin (TCDD). Benzo(a)pyrene 160-174 aryl hydrocarbon receptor Rattus norvegicus 0-3 23026235-2 2012 AhR is ligand activated transcription factor with high affinities for aromatic planar compounds such as beta-naphthoflavone (BNF), 3-methylcholanthrene (3-MC), benzo[a]pyrene (BaP) or dioxin (TCDD). Benzo(a)pyrene 176-179 aryl hydrocarbon receptor Rattus norvegicus 0-3 22643862-4 2012 In contrast, the classical Ah receptor agonist benzo[a]pyrene was a potent inducer of CYP1A1 mRNA levels, with this effect being effectively antagonized by the two isothiocyanates. Benzo(a)pyrene 47-61 aryl hydrocarbon receptor Rattus norvegicus 27-38 20466593-1 2010 It has been shown that benzo[a]pyrene, a key component of cigarette smoke and an aryl hydrocarbon receptor (AhR) ligand, reduced growth of isolated rat follicles in vitro. Benzo(a)pyrene 23-37 aryl hydrocarbon receptor Rattus norvegicus 81-106 20466593-1 2010 It has been shown that benzo[a]pyrene, a key component of cigarette smoke and an aryl hydrocarbon receptor (AhR) ligand, reduced growth of isolated rat follicles in vitro. Benzo(a)pyrene 23-37 aryl hydrocarbon receptor Rattus norvegicus 108-111 20466593-3 2010 This study proposed that the reported adverse effects of benzo[a]pyrene on follicle growth are mediated through AhR activation. Benzo(a)pyrene 57-71 aryl hydrocarbon receptor Rattus norvegicus 112-115 20466593-7 2010 The results suggest that the adverse effects of benzo[a]pyrene on follicle growth, steroidogenesis and AMH output are mediated through activation of the AhR. Benzo(a)pyrene 48-62 aryl hydrocarbon receptor Rattus norvegicus 153-156 20466593-8 2010 Moreover, AhR antagonists such as resveratrol and 3,4-DMF may have therapeutic benefit in protecting the ovary against the adverse effects of AhR ligands, including benzo[a]pyrene. Benzo(a)pyrene 165-179 aryl hydrocarbon receptor Rattus norvegicus 10-13 20466593-8 2010 Moreover, AhR antagonists such as resveratrol and 3,4-DMF may have therapeutic benefit in protecting the ovary against the adverse effects of AhR ligands, including benzo[a]pyrene. Benzo(a)pyrene 165-179 aryl hydrocarbon receptor Rattus norvegicus 142-145 12927582-0 2003 Assessment of metabolites and AhR and CYP1A1 mRNA expression subsequent to prenatal exposure to inhaled benzo(a)pyrene. Benzo(a)pyrene 104-118 aryl hydrocarbon receptor Rattus norvegicus 30-33 16198082-3 2006 Furthermore, BaP can induce expression of CYP1A1 and CYP1B1 via the aryl hydrocarbon receptor. Benzo(a)pyrene 13-16 aryl hydrocarbon receptor Rattus norvegicus 68-93 16839212-1 2006 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor with which halogenated and polycyclic aromatic hydrocarbons such as dioxins and benzo[a]pyrene interact as ligands. Benzo(a)pyrene 159-173 aryl hydrocarbon receptor Rattus norvegicus 4-29 16839212-1 2006 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor with which halogenated and polycyclic aromatic hydrocarbons such as dioxins and benzo[a]pyrene interact as ligands. Benzo(a)pyrene 159-173 aryl hydrocarbon receptor Rattus norvegicus 31-34 12927582-8 2003 Hepatic upregulation of the aryl hydrocarbon receptor may modulate the potential for benzo(a)pyrene toxicity via the activation of cytochrome P450 and the subsequent deposition of lipophillic metabolites to developing central nervous system structures such as cerebral cortex and hippocampus. Benzo(a)pyrene 85-99 aryl hydrocarbon receptor Rattus norvegicus 28-53 20654404-7 1998 Only aryl hydrocarbon receptor (AhR) ligands (BaP, TCDD and TCDF) depleted intracellular glutathione (GSH) in GMCs, while extended exposures to BaP and TCDD, as well as NAPH and 2-MNAPH, were associated with rebound increases in cellular GSH content. Benzo(a)pyrene 46-49 aryl hydrocarbon receptor Rattus norvegicus 5-30 12559965-7 2003 Prototypic AHR agonists benzo[a]pyrene (BaP) or 7,12-dimethylbenzanthracene (DMBA) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) repressed T-cadherin mRNA levels. Benzo(a)pyrene 24-38 aryl hydrocarbon receptor Rattus norvegicus 11-14 12559965-7 2003 Prototypic AHR agonists benzo[a]pyrene (BaP) or 7,12-dimethylbenzanthracene (DMBA) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) repressed T-cadherin mRNA levels. Benzo(a)pyrene 40-43 aryl hydrocarbon receptor Rattus norvegicus 11-14 12119129-8 2002 We speculate that BaP may interact with the aryl hydrocarbon receptor (AhR) in these cells and that AhR may target activated BaP to the nucleus. Benzo(a)pyrene 18-21 aryl hydrocarbon receptor Rattus norvegicus 44-69 12119129-8 2002 We speculate that BaP may interact with the aryl hydrocarbon receptor (AhR) in these cells and that AhR may target activated BaP to the nucleus. Benzo(a)pyrene 18-21 aryl hydrocarbon receptor Rattus norvegicus 71-74 12119129-8 2002 We speculate that BaP may interact with the aryl hydrocarbon receptor (AhR) in these cells and that AhR may target activated BaP to the nucleus. Benzo(a)pyrene 125-128 aryl hydrocarbon receptor Rattus norvegicus 100-103 10818089-3 2000 Overexpression of C/EBP-beta or C/EBP-alpha repressed, whereas AhR enhanced, 1.6CAT reporter activity in cells treated with benzo(a)pyrene (BaP). Benzo(a)pyrene 124-138 aryl hydrocarbon receptor Rattus norvegicus 63-66 10818089-3 2000 Overexpression of C/EBP-beta or C/EBP-alpha repressed, whereas AhR enhanced, 1.6CAT reporter activity in cells treated with benzo(a)pyrene (BaP). Benzo(a)pyrene 140-143 aryl hydrocarbon receptor Rattus norvegicus 63-66 20654404-7 1998 Only aryl hydrocarbon receptor (AhR) ligands (BaP, TCDD and TCDF) depleted intracellular glutathione (GSH) in GMCs, while extended exposures to BaP and TCDD, as well as NAPH and 2-MNAPH, were associated with rebound increases in cellular GSH content. Benzo(a)pyrene 46-49 aryl hydrocarbon receptor Rattus norvegicus 32-35 20654404-7 1998 Only aryl hydrocarbon receptor (AhR) ligands (BaP, TCDD and TCDF) depleted intracellular glutathione (GSH) in GMCs, while extended exposures to BaP and TCDD, as well as NAPH and 2-MNAPH, were associated with rebound increases in cellular GSH content. Benzo(a)pyrene 144-147 aryl hydrocarbon receptor Rattus norvegicus 5-30 20654404-7 1998 Only aryl hydrocarbon receptor (AhR) ligands (BaP, TCDD and TCDF) depleted intracellular glutathione (GSH) in GMCs, while extended exposures to BaP and TCDD, as well as NAPH and 2-MNAPH, were associated with rebound increases in cellular GSH content. Benzo(a)pyrene 144-147 aryl hydrocarbon receptor Rattus norvegicus 32-35 1316759-5 1992 Although BaP is believed to bind to both the Ah receptor and the 4S protein, BeP has been reported to bind exclusively to the 4S protein. Benzo(a)pyrene 9-12 aryl hydrocarbon receptor Rattus norvegicus 45-56 20654398-5 1998 The aryl hydrocarbon receptor agonists upregulated hepatocyte GSH levels by 24 hr, a response which in the case of BaP was preceded by varying degrees of GSH depletion between 6 to 16 hr. Benzo(a)pyrene 115-118 aryl hydrocarbon receptor Rattus norvegicus 4-29 31694515-5 2019 Our results confirm the existence of the AhR-mediated pathway in the regulation of expression of miR-483-3p, IGF1, and IGF2 under BP exposure, which is of considerable interest for understanding the epigenetic mechanisms of the carcinogenic effect of BP. Benzo(a)pyrene 130-132 aryl hydrocarbon receptor Rattus norvegicus 41-44 3402044-5 1988 Benzo[a]pyrene (B[a]P) binds with moderate affinity to both the Ah receptor and 4-5S binding protein and induces AHH in both -4S and +4S rats. Benzo(a)pyrene 0-14 aryl hydrocarbon receptor Rattus norvegicus 64-75 32588828-0 2020 [Effect of benzo(a)pyrene on the expression of AhR-regulated microRNA in female and male rat lungs]. Benzo(a)pyrene 11-25 aryl hydrocarbon receptor Rattus norvegicus 47-50 32588828-10 2020 Thus, our results suggest that sex-dependent epigenetic effects of BP may be based on different expression of AhR- and ER- regulated miRNAs. Benzo(a)pyrene 67-69 aryl hydrocarbon receptor Rattus norvegicus 110-113 31694515-1 2019 Here, we suggested that the epigenetic mechanism of benzo(a)pyrene (BP) action might be based on the aryl hydrocarbon receptor (AhR)-mediated transcription of the target genes, including miRNAs, that have the dioxin response element (DRE) in their promoters. Benzo(a)pyrene 52-66 aryl hydrocarbon receptor Rattus norvegicus 101-126 31694515-1 2019 Here, we suggested that the epigenetic mechanism of benzo(a)pyrene (BP) action might be based on the aryl hydrocarbon receptor (AhR)-mediated transcription of the target genes, including miRNAs, that have the dioxin response element (DRE) in their promoters. Benzo(a)pyrene 52-66 aryl hydrocarbon receptor Rattus norvegicus 128-131 31694515-1 2019 Here, we suggested that the epigenetic mechanism of benzo(a)pyrene (BP) action might be based on the aryl hydrocarbon receptor (AhR)-mediated transcription of the target genes, including miRNAs, that have the dioxin response element (DRE) in their promoters. Benzo(a)pyrene 68-70 aryl hydrocarbon receptor Rattus norvegicus 101-126 31694515-1 2019 Here, we suggested that the epigenetic mechanism of benzo(a)pyrene (BP) action might be based on the aryl hydrocarbon receptor (AhR)-mediated transcription of the target genes, including miRNAs, that have the dioxin response element (DRE) in their promoters. Benzo(a)pyrene 68-70 aryl hydrocarbon receptor Rattus norvegicus 128-131 34199736-1 2021 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that heterodimerizes with the AhR nuclear translocator (ARNT) to modulate CYP1A1 expression, a gene involved in the biotransformation of benzo(a)pyrene (BaP). Benzo(a)pyrene 216-230 aryl hydrocarbon receptor Rattus norvegicus 4-29 34199736-1 2021 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that heterodimerizes with the AhR nuclear translocator (ARNT) to modulate CYP1A1 expression, a gene involved in the biotransformation of benzo(a)pyrene (BaP). Benzo(a)pyrene 216-230 aryl hydrocarbon receptor Rattus norvegicus 31-34 34199736-1 2021 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that heterodimerizes with the AhR nuclear translocator (ARNT) to modulate CYP1A1 expression, a gene involved in the biotransformation of benzo(a)pyrene (BaP). Benzo(a)pyrene 232-235 aryl hydrocarbon receptor Rattus norvegicus 4-29 34199736-1 2021 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that heterodimerizes with the AhR nuclear translocator (ARNT) to modulate CYP1A1 expression, a gene involved in the biotransformation of benzo(a)pyrene (BaP). Benzo(a)pyrene 232-235 aryl hydrocarbon receptor Rattus norvegicus 31-34 32112355-6 2020 Treatment with AhR agonist benzo(a)pyrene aggravated GN as indicated by a significant increase in serum creatinine, BUN, KIM1, NAGL, CD-86, and urinary albumin/creatinine ratio. Benzo(a)pyrene 27-41 aryl hydrocarbon receptor Rattus norvegicus 15-18 31694515-5 2019 Our results confirm the existence of the AhR-mediated pathway in the regulation of expression of miR-483-3p, IGF1, and IGF2 under BP exposure, which is of considerable interest for understanding the epigenetic mechanisms of the carcinogenic effect of BP. Benzo(a)pyrene 251-253 aryl hydrocarbon receptor Rattus norvegicus 41-44 27167070-5 2016 Coadministration of BP and menadione reduced DNA-binding activity of AhR and increased DNA-binding activity of transcription factors Oct-1 and CCAAT/enhancer binding protein (C/EBP), which are known to be involved in negative regulation of AhR-dependent genes, in vivo. Benzo(a)pyrene 20-22 aryl hydrocarbon receptor Rattus norvegicus 69-72 27167070-5 2016 Coadministration of BP and menadione reduced DNA-binding activity of AhR and increased DNA-binding activity of transcription factors Oct-1 and CCAAT/enhancer binding protein (C/EBP), which are known to be involved in negative regulation of AhR-dependent genes, in vivo. Benzo(a)pyrene 20-22 aryl hydrocarbon receptor Rattus norvegicus 240-243 23626760-4 2013 We simultaneously assessed mRNA level, protein expression and enzymatic activity of the CYP1A enzymes, as well as mRNA and protein expressions of the aryl hydrocarbon receptor (AhR), which mediates the BP effect. Benzo(a)pyrene 202-204 aryl hydrocarbon receptor Rattus norvegicus 150-175 23626760-4 2013 We simultaneously assessed mRNA level, protein expression and enzymatic activity of the CYP1A enzymes, as well as mRNA and protein expressions of the aryl hydrocarbon receptor (AhR), which mediates the BP effect. Benzo(a)pyrene 202-204 aryl hydrocarbon receptor Rattus norvegicus 177-180 31368503-5 2019 Three PAHs were selected, based on their presence in food and their affinity for the aryl hydrocarbon receptor (AhR): benzo(a)pyrene (BP), dibenzo(a,h)anthracene (DBA), and pyrene (PYR). Benzo(a)pyrene 118-132 aryl hydrocarbon receptor Rattus norvegicus 85-110 31368503-5 2019 Three PAHs were selected, based on their presence in food and their affinity for the aryl hydrocarbon receptor (AhR): benzo(a)pyrene (BP), dibenzo(a,h)anthracene (DBA), and pyrene (PYR). Benzo(a)pyrene 118-132 aryl hydrocarbon receptor Rattus norvegicus 112-115 31368503-5 2019 Three PAHs were selected, based on their presence in food and their affinity for the aryl hydrocarbon receptor (AhR): benzo(a)pyrene (BP), dibenzo(a,h)anthracene (DBA), and pyrene (PYR). Benzo(a)pyrene 134-136 aryl hydrocarbon receptor Rattus norvegicus 112-115 26303333-7 2015 In accordance with such a hypothesis, the AhR activator benzo[a]pyrene induced the mINDY expression in primary cultures of rat hepatocytes in an AhR-dependent manner. Benzo(a)pyrene 56-70 aryl hydrocarbon receptor Rattus norvegicus 42-45 26303333-7 2015 In accordance with such a hypothesis, the AhR activator benzo[a]pyrene induced the mINDY expression in primary cultures of rat hepatocytes in an AhR-dependent manner. Benzo(a)pyrene 56-70 aryl hydrocarbon receptor Rattus norvegicus 145-148 25489928-3 2015 The current study shows that benzo[a]pyrene, a frequent contaminant of processed food and activator of the arylhydrocarbon receptor (AhR) activated the promoter and induced the transcription of the nuclear receptor constitutive androstane receptor (CAR, NR1I3) in rat hepatocytes. Benzo(a)pyrene 29-43 aryl hydrocarbon receptor Rattus norvegicus 133-136 25489928-7 2015 By inducing the AhR, phenobarbital enhanced the benzo[a]pyrene-dependent reduction of thyroid hormone half-life and the benzo[a]pyrene-dependent increase in the rate of thyroid hormone glucuronide formation in hepatocyte cultures. Benzo(a)pyrene 48-62 aryl hydrocarbon receptor Rattus norvegicus 16-19 25489928-7 2015 By inducing the AhR, phenobarbital enhanced the benzo[a]pyrene-dependent reduction of thyroid hormone half-life and the benzo[a]pyrene-dependent increase in the rate of thyroid hormone glucuronide formation in hepatocyte cultures. Benzo(a)pyrene 120-134 aryl hydrocarbon receptor Rattus norvegicus 16-19