PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33991922-4	2021	In this study, complexes of BaP with CYP1A1, CYP1B1 or CYP2C19 compound I were successfully simulated by QM/MM methods and verified by metabolic clearance, and the mutagenicity of chemicals was then predicted by the BaP-7,8-epoxide-related metabolic conformation fitness (MCF) approach, which was validated by Ames tests, showing satisfying accuracy (R2 = 0.46-0.66).	Benzo(a)pyrene	28-31	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	45-51	
32730838-6	2020	3-Methylcholanthrene (3-MC), benz[a]anthracene (B[a]A), benzo[a]pyrene (B[a]P), and valproic acid (VPA) increased the expression of CYP1B1 and CYP1A1.	Benzo(a)pyrene	56-70	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	132-138	
30137621-8	2018	Ectopic expression of human CYP1A1 and CYP1B1 enzymes partly restored both BaP metabolism and its effects on cell proliferation.	Benzo(a)pyrene	75-78	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	39-45	
31515600-10	2019	Compared to BaP or PhIP treatment alone, IL-6 plus BaP or PhIP selectively induced CYP1B1 significantly in both cell lines.	Benzo(a)pyrene	51-54	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	83-89	
31515600-12	2019	These data show that BaP- and PhIP-induced DNA damage in mammary cells is potentiated by the inflammatory cytokine IL-6 and that inflammation-induced CYP expression, specifically CYP1B1 via miR27b, is responsible for this effect.	Benzo(a)pyrene	21-24	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	179-185	
31092429-5	2019	RESULTS: DATS enhanced BaP-induced CYP1A1 and CYP1B1 mRNA expression, BaP hydroxylation and BaP-DNA adduct formation.	Benzo(a)pyrene	23-26	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	46-52	
24736433-11	2014	Using p53 heterozygous mutant epithelial cells from patients with Li-Fraumeni syndrome, we show that monoallelic mutation of p53 was associated with elevated levels of CYP1A1 and CYP1B1 under both basal conditions and following treatment with benzo[a]pyrene.	Benzo(a)pyrene	243-257	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	179-185	
27486223-5	2016	Also relative to human AHR, the Neandertal AHR exhibited 150-1000 times greater sensitivity to induction of Cyp1a1 and Cyp1b1 expression by PAHs (e.g., benzo(a)pyrene).	Benzo(a)pyrene	152-166	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	119-125	
25245543-5	2014	In cells exposed to 4.0 microM BP for 12h, RNA cpn values were 251-13234 for CYP1A1, 4133-57078 for CYP1B1 and 4456-55887 for NQO1.	Benzo(a)pyrene	31-33	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	100-106	
25245543-7	2014	In the NHMECs, BP-induced CYP1A1 RNA cpn was highly associated with BPdG (P = 0.002), but CYP1B1 and NQO1 were not.	Benzo(a)pyrene	15-17	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	90-96	
24695682-0	2014	CYP1B1 mRNA inducibility due to benzo(a)pyrene is modified by the CYP1B1 L432V gene polymorphism.	Benzo(a)pyrene	32-46	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-6	
24695682-0	2014	CYP1B1 mRNA inducibility due to benzo(a)pyrene is modified by the CYP1B1 L432V gene polymorphism.	Benzo(a)pyrene	32-46	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	66-72	
24695682-1	2014	Benzo(a)pyrene (BaP), a primary component of tobacco smoke, is activated by cytochrome P450 1B1 (CYP1B1).	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	97-103	
28247504-3	2017	Co-treatment with 5 microM BaP and 20 microM EGCG in BEAS-2B promoted a significant reduction in cell viability and greater G2/M cell cycle arrest, induction of ROS, and reductions in BaP-induced CYP1A1/CYP1B1/COMT, EGFR, p-Akt (Ser473), p-p53 (Thr55), and survivin mRNA/protein expression, as well as an increase in p-p53 (Ser15).	Benzo(a)pyrene	27-30	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	203-209	
28405246-11	2017	Conversely, CYP1B1 is thought to contribute only to the metabolic activation of BaP related to carcinogenesis.	Benzo(a)pyrene	80-83	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	12-18	
25199627-5	2014	First, BaP-induced expression of key metabolic enzymes was analysed; expression levels of the activating CYP1A1 and CYP1B1 were increased, while the detoxifying enzymes UGT1A6 and UGT2B7 were significantly reduced by hypoxia.	Benzo(a)pyrene	7-10	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	116-122	
24736433-12	2014	Treatment with CP-31398, a p53 rescue compound, suppressed benzo[a]pyrene-mediated induction of CYP1A1 and CYP1B1 and the formation of DNA adducts.	Benzo(a)pyrene	59-73	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	107-113	
20399842-2	2010	BP is converted in liver and lung to benzo(a)pyrene-7,8-diol-9,10-epoxide (BPDE) by the enzymes of the cytochrome P450 (CYP) superfamily, namely CYP1A1/1A2, and CYP1B1.	Benzo(a)pyrene	0-2	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	161-167	
23325794-0	2013	Genetic polymorphisms in catalase and CYP1B1 determine DNA adduct formation by benzo(a)pyrene ex vivo.	Benzo(a)pyrene	79-93	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	38-44	
21920623-8	2012	Benzo[a]pyrene increased expression of CYP1B1 over CYP1A1 and suppressed estrogen-induced COMT up-regulation in ERalpha(-) tumor cells, probably switching estrogen metabolism to 4-hydroxyestradiol formation and removing the inhibition of 2-methoxyestradiol on ERalpha(-) tumors.	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	39-45	
21669939-6	2011	The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 muM BP, 1 muM BP + 1 muM TMS or 1 muM BP + 4 muM TMS, respectively.	Benzo(a)pyrene	180-182	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	37-43	
21669939-6	2011	The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 muM BP, 1 muM BP + 1 muM TMS or 1 muM BP + 4 muM TMS, respectively.	Benzo(a)pyrene	190-192	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	37-43	
21669939-6	2011	The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 muM BP, 1 muM BP + 1 muM TMS or 1 muM BP + 4 muM TMS, respectively.	Benzo(a)pyrene	190-192	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	37-43	
21669939-8	2011	Therefore, during 96 h of exposure in MCF-7 cells, the combination of BP plus TMS caused a slowing of BP biotransformation, with an increase in CYP1A1 and CYP1B1 expression and EROD activity, and a slowing, but no change in magnitude of BPdG formation.	Benzo(a)pyrene	70-72	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	155-161	
25658124-1	2014	CYP1B1, a recently described dioxin inducible oxidoreductase, is a member of the cytochrome P450 superfamily involved in the metabolism of estradiol, retinol, benzo[a]pyrene, tamoxifen, melatonin, sterols etc.	Benzo(a)pyrene	159-173	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-6	
22374940-6	2012	Treatment of cell lines derived from oral leukoplakia (MSK-Leuk1) and skin (HaCaT) with benzo[a]pyrene (B[a]P), a prototypic PAH, induced CYP1A1 and CYP1B1 transcription, resulting in enhanced levels of message and protein.	Benzo(a)pyrene	88-102	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	149-155	
21507987-4	2011	However, our study shows that BRCA1 defective cells may still be able to biotransform BaP by regulating other CYP enzymes, including CYP1B1.	Benzo(a)pyrene	86-89	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	133-139	
21028851-2	2011	Benzo[a]pyrene (B[a]P), a prototypic PAH, is metabolized by cytochrome P450 (P450) 1A1/1B1 and epoxide hydrolase to (-)-B[a]P-7,8-dihydro-7,8-diol (B[a]P-7,8-dihydrodiol).	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	60-90	
20163913-2	2010	Here, we examined the induction and modulation of CYP1A1 and CYP1B1 and 10-(deoxyguanosin-N(2)-yl)-7,8,9-trihydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPdG) adduct formation in DNA from 20 primary normal human mammary epithelial cell (NHMEC) strains exposed to BP (4muM) in the absence or presence of chlorophyllin (5muM).	Benzo(a)pyrene	151-153	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	61-67	
20163913-0	2010	CYP1A1 and CYP1B1 gene expression and DNA adduct formation in normal human mammary epithelial cells exposed to benzo[a]pyrene in the absence or presence of chlorophyllin.	Benzo(a)pyrene	111-125	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	11-17	
20163913-3	2010	Real-time polymerase chain reaction (RT-PCR) analysis revealed strong induction of both CYP1A1 and CYP1B1 by BP, with high levels of inter-individual variability.	Benzo(a)pyrene	109-111	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	99-105	
20163913-5	2010	Chlorophyllin mitigated BP-induced CYP1A1 and CYP1B1 gene expression in all 20 strains when administered with BP.	Benzo(a)pyrene	24-26	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	46-52	
20163913-5	2010	Chlorophyllin mitigated BP-induced CYP1A1 and CYP1B1 gene expression in all 20 strains when administered with BP.	Benzo(a)pyrene	110-112	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	46-52	
19879933-0	2010	Importance of CYP1A1 and CYP1B1 in bioactivation of benzo[a]pyrene in human lung cell lines.	Benzo(a)pyrene	52-66	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	25-31	
19406224-7	2009	Gene expression analysis at 4 and 24h following benzo(a)pyrene exposure revealed the induction of cyp1a1, cyp1a2, and cyp1b1 in FE1 cells and lung isolates.	Benzo(a)pyrene	48-62	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	118-124	
19919601-1	2010	Administration of melatonin to rodents decreases the incidence of tumorigenesis initiated by benzo[a]pyrene or 7,12-dimethylbenz[a]anthracene, which requires bioactivation by cytochrome P450 enzymes, such as CYP1A1, CYP1A2 and CYP1B1, to produce carcinogenic metabolites.	Benzo(a)pyrene	93-107	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	227-233	
18372000-4	2008	In this study, we assessed the effects of CYP1 enzymes (CYP1A1, CYP1A2 and CYP1B1) on BaP-induced AhR transactivation and DNA adduct formation in HEK293 cells and HepG2 cells.	Benzo(a)pyrene	86-89	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	75-81	
19152381-7	2009	Using reverse transcription real time PCR (RT-PCR) the maximal inhibition of BP-induced gene expression, >85% for CYP1A1 and >70% for CYP1B1, was observed in the preCHLN, postBP+CHLN group.	Benzo(a)pyrene	77-79	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	140-146	
19152381-11	2009	Therefore, the addition of CHLN to BP-exposed cells reduced BPdG formation and CYP1A1 and CYP1B1 expression, but EROD activity was not significantly reduced.	Benzo(a)pyrene	35-37	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	90-96	
18372000-5	2008	Transfection of CYP1A1 and CYP1B1, but not CYP1A2, suppressed BaP-induced activation of AhR.	Benzo(a)pyrene	62-65	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	27-33	
18372000-7	2008	These results indicate that CYP1A1 and CYP1B1 play a role in deactivation of BaP on AhR and that CYP1A1 and CYP1A2 are involved in BaP detoxification by suppressing DNA adduct formation.	Benzo(a)pyrene	77-80	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	39-45	
18372000-10	2008	Dynamic expression of CYP1A1, CYP1A2 and CYP1B1 along with expression of other enzymes such as epoxide hydrolase and phase II enzymes may determine the detoxification or metabolic activation of BaP.	Benzo(a)pyrene	194-197	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	41-47	
16185837-9	2006	Further, RFFO extract caused a dose dependent increase (2.1-3.5-fold) in aryl hydrocarbon hydroxylase (AHH) activity at 48 h. Induction of EROD and AHH activity in Hep G2 cells was found to be relatively more following BP or chrysene treatment as compared to RFFO extract.	Benzo(a)pyrene	219-221	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	73-101	
18336845-8	2008	Only CYP1B1 and ALDH1A3 were consistently up-regulated by approximately 3-fold in most of the cell strains (at least 4) when exposed to BP.	Benzo(a)pyrene	136-138	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	5-11	
17261025-5	2007	Using benzo[a]pyrene as a test substrate, enzyme activity for producing DNA damage in the arrays was found in the order CYP1B1 > CYP1A2 > CYP1A1 > CYP2E1 > myoglobin, the same as the order of their metabolic activity.	Benzo(a)pyrene	6-20	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	120-126	
16530937-0	2007	Cytochrome P450 1B1, a novel chemopreventive target for benzo[a]pyrene-initiated human esophageal cancer.	Benzo(a)pyrene	56-70	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-19	
16484233-4	2006	BaP exposure also increased both CYP1A1/1B1 and microsomal epoxide hydrolase (mEH) enzyme activities with a maximum 10-fold increase at 48 h. BaP induced CYP1A1 protein and mRNA levels maximally after 48 h. In contrast, although CYP1B1 mRNA was rapidly induced, its protein expression showed a very poor response.	Benzo(a)pyrene	0-3	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	229-235	
16484233-4	2006	BaP exposure also increased both CYP1A1/1B1 and microsomal epoxide hydrolase (mEH) enzyme activities with a maximum 10-fold increase at 48 h. BaP induced CYP1A1 protein and mRNA levels maximally after 48 h. In contrast, although CYP1B1 mRNA was rapidly induced, its protein expression showed a very poor response.	Benzo(a)pyrene	142-145	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	229-235	
17919675-0	2008	Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites.	Benzo(a)pyrene	59-73	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	24-30	
16226778-8	2006	G. biloba extract also reduced benzo[a]pyrene hydroxylation, and the effect was greater with CYP1B1 than with CYP1A1 as the catalyst.	Benzo(a)pyrene	31-45	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	93-99	
16185837-9	2006	Further, RFFO extract caused a dose dependent increase (2.1-3.5-fold) in aryl hydrocarbon hydroxylase (AHH) activity at 48 h. Induction of EROD and AHH activity in Hep G2 cells was found to be relatively more following BP or chrysene treatment as compared to RFFO extract.	Benzo(a)pyrene	219-221	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	103-106	
16120219-9	2005	BaP upregulated the expression of CYP1B1 at 6-24 h and downregulated many cell cycle regulatory genes at 48-72 h. By contrast, PhIP increased the expression of many cell cycle regulatory genes.	Benzo(a)pyrene	0-3	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	34-40	
16237193-8	2006	BaP- and TCDD-induced mRNA and protein levels of CYP1A1 and CYP1B1 levels were significantly elevated in CCSP-positive cell cultures.	Benzo(a)pyrene	0-3	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	60-66	
16162842-5	2005	Induction of CYP1A1 and CYP1B1 protein expression was observed by immunoblots in cells treated with BP alone or in co-treatments of SRM 1649a and BP or DBP.	Benzo(a)pyrene	100-102	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	24-30	
16162842-5	2005	Induction of CYP1A1 and CYP1B1 protein expression was observed by immunoblots in cells treated with BP alone or in co-treatments of SRM 1649a and BP or DBP.	Benzo(a)pyrene	146-148	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	24-30	
15905203-0	2005	Preferential induction of CYP1B1 by benzo[a]pyrene in human oral epithelial cells: impact on DNA adduct formation and prevention by polyphenols.	Benzo(a)pyrene	36-50	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	26-32	
15905203-3	2005	Furthermore, BaP induced both CYP1B1 and CYP1A1 mRNA and protein expression, as determined by the branched DNA assay and western blot analysis, but with considerably higher levels of CYP1B1.	Benzo(a)pyrene	13-16	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	30-36	
15905203-3	2005	Furthermore, BaP induced both CYP1B1 and CYP1A1 mRNA and protein expression, as determined by the branched DNA assay and western blot analysis, but with considerably higher levels of CYP1B1.	Benzo(a)pyrene	13-16	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	183-189	
15890477-6	2005	In summary, our study shows that the induction of both CYP1A1 and CYP1B1 resulted in an accelerated metabolism and an enhanced clearance of the potent procarcinogen BP, indicating that flavone, indole-3-carbinol and oltipraz have an impact on the biochemical barrier against BP in intestinal cells.	Benzo(a)pyrene	165-167	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	66-72	
15890477-6	2005	In summary, our study shows that the induction of both CYP1A1 and CYP1B1 resulted in an accelerated metabolism and an enhanced clearance of the potent procarcinogen BP, indicating that flavone, indole-3-carbinol and oltipraz have an impact on the biochemical barrier against BP in intestinal cells.	Benzo(a)pyrene	275-277	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	66-72	
8759031-1	1996	Evidence for CYP1A1 and CYP1B1 expression and their involvement in benzo[a]pyrene metabolism.	Benzo(a)pyrene	67-81	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	24-30	
15713371-2	2005	Benzo[a]pyrene (B[a]P) induces cytochrome P450 (CYP) 1A1, CYP1B1 and other xenobiotic metabolizing enzymes.	Benzo(a)pyrene	0-14	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	58-64	
15713371-2	2005	Benzo[a]pyrene (B[a]P) induces cytochrome P450 (CYP) 1A1, CYP1B1 and other xenobiotic metabolizing enzymes.	Benzo(a)pyrene	16-21	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	58-64	
15713371-4	2005	However, co-treatment with 1.0 microM SAHA and BP, reduced the mRNA levels of CYP1B1 relative to B[a]P alone.	Benzo(a)pyrene	47-49	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	78-84	
15713371-5	2005	When co-treated with 1.0 microM TSA and BP, a reduction in the mRNA levels of both CYP1A1 and CYP1B1 was observed relative to BP alone.	Benzo(a)pyrene	40-42	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	94-100	
15713371-5	2005	When co-treated with 1.0 microM TSA and BP, a reduction in the mRNA levels of both CYP1A1 and CYP1B1 was observed relative to BP alone.	Benzo(a)pyrene	126-128	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	94-100	
12396873-8	2002	Treatment with 10 micro M benzo[a]pyrene, a component of MEP extract, for 24 h induced catalytic activity, protein, and mRNA of cytochromes P-450 1A1 and 1B1 in MCF-7 cells.	Benzo(a)pyrene	26-40	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	140-157	
12183407-4	2002	Stratified analysis and regression analysis demonstrated that race, pack-years of smoking, family history of breast cancer, and CYP1B1 genotype were significant predictors of the level of benzo(a)pyrene-induced adducts in the breast tissues.	Benzo(a)pyrene	188-202	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	128-134	
12127040-10	2002	CYP1 activity in BP-induced cells was significantly inhibited by specific anti-CYP1A1 and high concentration of alpha-naphthoflavone (ANF, 100nM), but not by selective CYP1A2 (furafylline) and CYP1B1 (homoeriodictoyl) inhibitors and low concentration of ANF (5nM).	Benzo(a)pyrene	17-19	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	193-199	
11854143-0	2002	Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite.	Benzo(a)pyrene	69-83	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	24-30	
11921196-7	2002	Interestingly, endogenous 17beta-estradiol (E(2)) is metabolized by the cytochrome P450 enzyme isoforms CYP1A1 and CYP1B1, which also activate benzo[a]pyrene (B[a]P), a carcinogen contained in cigarette smoke.	Benzo(a)pyrene	143-157	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	115-121	
11465393-0	2001	Specificity of 17beta-oestradiol and benzo[a]pyrene oxidation by polymorphic human cytochrome P4501B1 variants substituted at residues 48, 119 and 432.	Benzo(a)pyrene	37-51	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	83-101	
11465393-10	2001	In contrast, Leu432 forms of CYP1B1 showed higher rates of oxidation of benzo[a]pyrene (to the 7,8-dihydoxy-7,8-dihydrodiol in the presence of epoxide hydrolase) than did the Val432 forms.	Benzo(a)pyrene	72-86	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	29-35	
11465393-12	2001	These results suggest that polymorphic human CYP1B1 variants may cause some altered catalytic specificity with 17beta-oestradiol and benzo[a]pyrene and may influence susceptibilities of individuals towards endogenous and exogenous carcinogens.	Benzo(a)pyrene	133-147	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	45-51	
15958554-0	2005	Characterization of common CYP1B1 variants with different capacity for benzo[a]pyrene-7,8-dihydrodiol epoxide formation from benzo[a]pyrene.	Benzo(a)pyrene	71-85	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	27-33	
15958554-3	2005	In this study, we have investigated CYP1B1 haplotypes present in a Spanish population and carried out functional analyses of the corresponding enzymes in yeast using benzo[a]pyrene as a substrate.	Benzo(a)pyrene	166-180	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	36-42	
15958554-5	2005	The variant CYP1B1 forms were heterologously expressed with human reductase in Saccharomyces cerevisiae and kinetic analyses of benzo[a]pyrene metabolism were carried out.	Benzo(a)pyrene	128-142	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	12-18	
15808407-0	2005	Induction of CYP1A1 and CYP1B1 and formation of carcinogen-DNA adducts in normal human mammary epithelial cells treated with benzo[a]pyrene.	Benzo(a)pyrene	125-139	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	24-30	
15808407-7	2005	On a per-person basis, CYP1A1 and CYP1B1 induction were well-correlated (r=0.88, P<0.001), which is to be expected as they are under the control of a common transcriptional regulation mechanism in response to BP exposure.	Benzo(a)pyrene	212-214	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	34-40	
15735009-5	2005	Increase in expression of cytochrome P450 (CYP) genes was observed in response to BP exposure (CYP1A1 and CYP1B1; signal log ratio of 4.7 and 2.5, respectively).	Benzo(a)pyrene	82-84	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	106-112	
15297370-1	2004	Several members of the P450 family, including cytochrome P450 1B1 (CYP1B1), can convert tobacco smoke (TS) procarcinogens, including benzo[a]pyrene (B[a]P), to carcinogenic intermediates.	Benzo(a)pyrene	133-147	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	67-73	
10739169-1	2000	Cytochrome P450 1B1 (CYP1B1) participates in the metabolic activation of a number of procarcinogens including benzo[a]pyrene and the hydroxylation of 17beta-estradiol at the C-4 position.	Benzo(a)pyrene	110-124	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-19	
10739169-1	2000	Cytochrome P450 1B1 (CYP1B1) participates in the metabolic activation of a number of procarcinogens including benzo[a]pyrene and the hydroxylation of 17beta-estradiol at the C-4 position.	Benzo(a)pyrene	110-124	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	21-27	
10409402-0	1999	Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase.	Benzo(a)pyrene	14-28	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	100-119	
10409402-2	1999	Activation of benzo[a]pyrene to genotoxic products that cause induction of umu gene expression in Salmonella typhimurium NM2009 by P450 1A1 and P450 1B1 enzymes was found to be enhanced by inclusion of purified epoxide hydrolase (isolated from rat or human livers) with the reaction mixture.	Benzo(a)pyrene	14-28	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	144-152	
10409402-6	1999	A reconstituted system containing purified P450 1B1, rabbit liver NADPH-P450 reductase, and human liver epoxide hydrolase was found to catalyze benzo[a]pyrene to trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene at a rate of 0.86 nmol min(-)(1) nmol of P450(-)(1); the activities were found to be largely dependent on the presence of sodium cholate in the system.	Benzo(a)pyrene	144-158	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	43-51	
10409402-7	1999	These results suggest that P450 1B1 is a principal enzyme in catalyzing the oxidation of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene and that the catalytic functions of P450 1B1 may determine the susceptibilities of individuals to benzo[a]pyrene carcinogenesis.	Benzo(a)pyrene	89-103	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	27-35	
10409402-7	1999	These results suggest that P450 1B1 is a principal enzyme in catalyzing the oxidation of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene and that the catalytic functions of P450 1B1 may determine the susceptibilities of individuals to benzo[a]pyrene carcinogenesis.	Benzo(a)pyrene	89-103	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	190-198	
10409402-7	1999	These results suggest that P450 1B1 is a principal enzyme in catalyzing the oxidation of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene and that the catalytic functions of P450 1B1 may determine the susceptibilities of individuals to benzo[a]pyrene carcinogenesis.	Benzo(a)pyrene	139-153	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	27-35	
10409402-7	1999	These results suggest that P450 1B1 is a principal enzyme in catalyzing the oxidation of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene and that the catalytic functions of P450 1B1 may determine the susceptibilities of individuals to benzo[a]pyrene carcinogenesis.	Benzo(a)pyrene	139-153	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	190-198	
9806168-0	1998	Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1.	Benzo(a)pyrene	14-28	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	66-85	
9806168-5	1998	The results of these studies indicate that cytochrome P450 1B1 carries out metabolism of B[a]P along the pathway to the postulated ultimate carcinogen, the diol epoxide 2, at rates much higher than P450 1A2 but less than P450 1A1.	Benzo(a)pyrene	89-94	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	43-62	
9152602-5	1997	CYP1B1 catalyzed benzo[a]pyrene 3-hydroxylation at rates lower than those of CYP1A1 but higher than those of CYP1A2.	Benzo(a)pyrene	17-31	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-6	
8759031-7	1996	BaP and TCDD also induced expression of the CYP1B1 protein and the pattern of induction was comparable to that observed for CYP1A1.	Benzo(a)pyrene	0-3	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	44-50	
8759031-9	1996	These results demonstrate that CYP1A1 and CYP1B1-related activities are induced in GMCs by BaP and TCDD and this induction is associated with metabolism of BaP to reactive intermediates that bind covalently to DNA.	Benzo(a)pyrene	91-94	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	42-48	
8759031-9	1996	These results demonstrate that CYP1A1 and CYP1B1-related activities are induced in GMCs by BaP and TCDD and this induction is associated with metabolism of BaP to reactive intermediates that bind covalently to DNA.	Benzo(a)pyrene	156-159	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	42-48	
2943442-0	1986	[Studies on the relationship between the activities of aryl hydrocarbon hydroxylase and the intermediate products of benzo(a)pyrene].	Benzo(a)pyrene	117-131	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	55-83	
34439562-6	2021	Cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1) and Cytochrome P450 subfamily B polypeptide 1 (CYP1B1) downregulation resulting from decreased aryl hydrocarbon receptor (AhR) translocation into nuclei attenuated the effects of B(a)P-induced lipid accumulation and repressed cell viability, respectively.	Benzo(a)pyrene	239-244	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	107-113	
35315151-11	2022	When exposed to pollution stress by treating the models with benzo(a)pyrene and airborne particulate matter (PM10), application of both formulations prior to exposure attenuated the induction of CYP1A1, CYP1B1 and UGT1A7 expression, indicating a protective effect.	Benzo(a)pyrene	61-75	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	203-209	
1765318-1	1991	The activity of aryl hydrocarbon hydroxylase (AHH) was measured in the placenta using radioenzymatic techniques and benzo(a)pyrene (BP) as substrate.	Benzo(a)pyrene	116-130	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	16-44	
1765318-1	1991	The activity of aryl hydrocarbon hydroxylase (AHH) was measured in the placenta using radioenzymatic techniques and benzo(a)pyrene (BP) as substrate.	Benzo(a)pyrene	116-130	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	46-49	
1765318-1	1991	The activity of aryl hydrocarbon hydroxylase (AHH) was measured in the placenta using radioenzymatic techniques and benzo(a)pyrene (BP) as substrate.	Benzo(a)pyrene	132-134	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	16-44	
1765318-1	1991	The activity of aryl hydrocarbon hydroxylase (AHH) was measured in the placenta using radioenzymatic techniques and benzo(a)pyrene (BP) as substrate.	Benzo(a)pyrene	132-134	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	46-49	
509413-3	1979	Of 3 compounds tested, benzo[a]pyrene (BP) stimulates the highest level of AHH activity.	Benzo(a)pyrene	23-37	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	75-78	
6516477-0	1984	[Aryl hydrocarbon hydroxylase in human lymphocytes: p-nitrophenetol as an alternative substrate to benzo(a)pyrene].	Benzo(a)pyrene	99-113	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	1-29	
6287253-3	1982	The hepatoma cells metabolized about 90% of 5 microM benzo[a]pyrene into water-soluble products within 24 h. Aryl hydrocarbon hydroxylase activity in huH-1 cells was induced to 24 times higher than the basal level by treatment with 13 microM benz[a]anthracene for 24 h. Metabolic activation of benzo[a]pyrene, dimethylnitrosamine and aflatoxin B1 by huH-1 cells was observed by cell-mediated sister-chromatid exchange assay.	Benzo(a)pyrene	53-67	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	109-137	
6287253-3	1982	The hepatoma cells metabolized about 90% of 5 microM benzo[a]pyrene into water-soluble products within 24 h. Aryl hydrocarbon hydroxylase activity in huH-1 cells was induced to 24 times higher than the basal level by treatment with 13 microM benz[a]anthracene for 24 h. Metabolic activation of benzo[a]pyrene, dimethylnitrosamine and aflatoxin B1 by huH-1 cells was observed by cell-mediated sister-chromatid exchange assay.	Benzo(a)pyrene	294-308	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	109-137	
6280710-0	1982	Effects of estrogens on aryl hydrocarbon hydroxylase mediated binding of benzo(a) pyrene metabolites to DNA in vitro.	Benzo(a)pyrene	73-88	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	24-52	
7357559-0	1980	High-pressure liquid chromatographic analysis of benzo(a)pyrene metabolism by human lymphocytes from donors of different aryl hydrocarbon hydroxylase inducibility and antipyrine half-lives.	Benzo(a)pyrene	49-63	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	121-149	
2875537-7	1986	Aryl hydrocarbon hydroxylase activity was measured with two different substrates, benzo(a)pyrene and 7-ethoxyresorufin.	Benzo(a)pyrene	82-96	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-28	
6629771-2	1983	The carcinogen benzo(a)pyrene is present in most coal tar preparations, and it is a potent inducer of the aryl hydrocarbon hydroxylase activity in liver and skin after topical application.	Benzo(a)pyrene	15-29	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	106-134	
6629771-3	1983	The formation of the most reactive metabolite of benzo(a)pyrene is catalyzed by aryl hydrocarbon hydroxylase hydroxylase.	Benzo(a)pyrene	49-63	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	80-108	
7442661-10	1980	Studies on the metabolism of benzo(a)pyrene revealed that the enzyme aryl hydrocarbon hydroxylase (AHH) is present in cultured hair follicle cells.	Benzo(a)pyrene	29-43	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	69-97	
7442661-10	1980	Studies on the metabolism of benzo(a)pyrene revealed that the enzyme aryl hydrocarbon hydroxylase (AHH) is present in cultured hair follicle cells.	Benzo(a)pyrene	29-43	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	99-102	
6256996-0	1980	[Studies on the activity of the aryl hydrocarbon hydroxylase and metabolism of benzo(a)pyrene in cell strains and cell lines used for testing cytotoxic and transforming ability of foreign compounds (author"s transl)].	Benzo(a)pyrene	79-93	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	32-60	
509413-3	1979	Of 3 compounds tested, benzo[a]pyrene (BP) stimulates the highest level of AHH activity.	Benzo(a)pyrene	39-41	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	75-78