PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1537398-0 1992 Proton NMR study of the interaction of benzo(a)pyrene with rat liver microsomal cytochrome P-450. Benzo(a)pyrene 39-53 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 80-96 1537398-2 1992 Upon addition of various amounts of cytochrome P-450 to solutions of BaP, the T1 values for the three BaP protons decreased. Benzo(a)pyrene 69-72 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 36-52 1537398-2 1992 Upon addition of various amounts of cytochrome P-450 to solutions of BaP, the T1 values for the three BaP protons decreased. Benzo(a)pyrene 102-105 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 36-52 1516151-0 1992 Organ-selective induction of cytochrome P-450-dependent activities by indole-3-carbinol-derived products: influence on covalent binding of benzo[a]pyrene to hepatic and pulmonary DNA in the rat. Benzo(a)pyrene 139-153 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 29-45 1494976-6 1992 Cytochrome P-450 levels and related biotransformation activity which are elevated by BP treatment were not decreased by the injection of BP and carrageenan simultaneously to male rats. Benzo(a)pyrene 85-87 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-16 1913623-0 1991 Effects of synthetic and naturally occurring flavonoids on benzo[a]pyrene metabolism by hepatic microsomes prepared from rats treated with cytochrome P-450 inducers. Benzo(a)pyrene 59-73 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 139-155 2125771-11 1990 For example, when the mutagenicity of benzo(a)pyrene and benzo(a)pyrene-3,6-quinone was studied in the Ames test, glucuronidation or glutathione conjugation (concomitant with cytochrome P-450-dependent reactions) markedly decreased their mutagenicity. Benzo(a)pyrene 38-52 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 175-191 1654904-3 1991 High positive correlation (r = 0.949) between the values of Vmax for reaction of NADPH-dependent anaerobic amaranch reduction and the relative content low spin forms of cytochrome P-450 determined by ESR in microsomes from liver of control and induced by PB, BP, IS and 4-MP rats was observed. Benzo(a)pyrene 259-261 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 169-185 1759389-2 1991 Distinct increase of cytochrome P-450 catalytic activity with amidopyrine and benzo-a-pyrene as substrates of the I type was found after hypoxia, subsequent hyperoxia resulted in significant increase of amidopyrine and benzo-a-pyrene metabolism in liver and lung tissues and of aniline metabolism in liver tissue. Benzo(a)pyrene 78-92 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 21-37 1759389-2 1991 Distinct increase of cytochrome P-450 catalytic activity with amidopyrine and benzo-a-pyrene as substrates of the I type was found after hypoxia, subsequent hyperoxia resulted in significant increase of amidopyrine and benzo-a-pyrene metabolism in liver and lung tissues and of aniline metabolism in liver tissue. Benzo(a)pyrene 219-233 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 21-37 1654602-6 1991 Two components of the monooxygenase system responsible for BP metabolism, cytochrome P-450 and NADPH-cytochrome P-450 reductase, are also inhibited by the two oxygen metabolites in a similar manner. Benzo(a)pyrene 59-61 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 74-90 2107605-7 1990 However, the vitamin A level was inversely related to the activities of drug metabolizing enzymes induced by coplanar compounds (cytochrome P-450 towards benzo[a]pyrene and UDP glucuronosyl transferase towards 4-nitrophenol). Benzo(a)pyrene 154-168 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 129-145 2364062-0 1990 Binding of benzo[a]pyrene to DNA by cytochrome P-450 catalyzed one-electron oxidation in rat liver microsomes and nuclei. Benzo(a)pyrene 11-25 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 36-52 2364062-4 1990 The specific cytochrome P-450 inhibitor 2-[(4,6-dichloro-o-biphenyl)oxy]ethylamine hydrobromide (DPEA) reduced or eliminated BP metabolism, binding of BP to DNA, and formation of BP-N7Gua by cytochrome P-450 in both microsomes and nuclei. Benzo(a)pyrene 125-127 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 13-29 2364062-4 1990 The specific cytochrome P-450 inhibitor 2-[(4,6-dichloro-o-biphenyl)oxy]ethylamine hydrobromide (DPEA) reduced or eliminated BP metabolism, binding of BP to DNA, and formation of BP-N7Gua by cytochrome P-450 in both microsomes and nuclei. Benzo(a)pyrene 151-153 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 13-29 2364062-4 1990 The specific cytochrome P-450 inhibitor 2-[(4,6-dichloro-o-biphenyl)oxy]ethylamine hydrobromide (DPEA) reduced or eliminated BP metabolism, binding of BP to DNA, and formation of BP-N7Gua by cytochrome P-450 in both microsomes and nuclei. Benzo(a)pyrene 151-153 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 191-207 2343577-6 1990 The primary metabolism of the hydrophobic BP involved cytochrome P-450 isoenzymes which had the active site directed inside the lipids; the secondary metabolism of more polar diols was realized using both groups of hemoprotein isoenzymes with active sites oriented into lipids and water. Benzo(a)pyrene 42-44 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 54-70 2072980-5 1990 It is postulated that different cytochrome P-450 isoenzymes participate in benzo(a)pyrene hydroxylation, whereas the second one acts at high concentration of both NADH and NADPH. Benzo(a)pyrene 75-89 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 32-48 2328803-1 1990 The long-term administration of xenobiotics carcinogens o-aminoazotoluene (o-AAT) and benz(a)pyrene (BP) to rats was found to cause induction of the liver cytochrome P-450 system which gradually decreases in spite of continued administration of the agents. Benzo(a)pyrene 86-99 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 155-171 2328803-1 1990 The long-term administration of xenobiotics carcinogens o-aminoazotoluene (o-AAT) and benz(a)pyrene (BP) to rats was found to cause induction of the liver cytochrome P-450 system which gradually decreases in spite of continued administration of the agents. Benzo(a)pyrene 101-103 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 155-171 2495007-6 1989 In contrast, in the kidney cytochrome P-450 concentration was significantly increased to (145-170% of the control), along with a modest decrease in benzo[a]pyrene hydroxylation activity. Benzo(a)pyrene 148-162 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 27-43 35437857-6 2022 BaP treatment showed significantly increased in the activities of Phase I biotransformation enzymes (Cytochrome P450 , b5 , and aryl hydrocarbon hydrolase) and inhibited the activity of Phase II enzyme (glutathione-S-transferase). Benzo(a)pyrene 0-3 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 101-121 2498299-0 1989 Purification and properties of cytochrome P-450 generally acting as a catalyst on benzo[a]pyrene hydroxylation from liver microsomes of untreated rats. Benzo(a)pyrene 82-96 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 31-47 2498299-1 1989 A form of cytochrome P-450 generally catalyzing benzo[a]pyrene (B[a]P) hydroxylation was purified from liver microsomes of untreated rats on the basis of the catalytic activity. Benzo(a)pyrene 48-62 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 10-26 3172284-3 1988 The increases of microsomal cytochrome b5 and cytochrome P-450 contents were noticed at 1, 12 and 24 hr after NCO-650 and BP administration. Benzo(a)pyrene 122-124 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 46-62 2844763-8 1988 The liver mitochondrial cytochrome P-450 hydroxylates vitamin D3 and 1 alpha-hydroxyvitamin D3 at position 25, but did not show any activity toward xenobiotics such as benzphetamine, 7-ethoxycoumarin, and benzo[a]pyrene. Benzo(a)pyrene 205-219 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 24-40 3142693-2 1988 The aim was to examine factors that might be of importance for the tumorigenicity of BP in the regenerating rat liver, such as cytochrome P-450 activity and glutathione levels. Benzo(a)pyrene 85-87 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 127-143 3335509-2 1988 Hepatic mitoplasts from 3-methylcholanthrene-treated rats contain cytochrome P-450 which can metabolize polycyclic aromatic hydrocarbons like benzo(a)pyrene. Benzo(a)pyrene 142-156 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 66-82 3181598-10 1988 Benzo(a)pyrene increased hepatic microsomal cytochrome P-450 content in rats on normal and selenium supplemented diet but not in the selenium deficient group. Benzo(a)pyrene 0-14 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 44-60 3142693-14 1988 Furthermore, MC, an inducer of certain cytochrome P-450 species ("aryl hydrocarbon hydroxylase"), potentiates the effect of BP. Benzo(a)pyrene 124-126 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 39-55 2866028-3 1985 Cytochrome P-450 dependent metabolism of benzo[a]pyrene, aldrin and ethoxyresorufin was 43-54% lower than in the parent cell suspension, glucuronidation of 3-hydroxybenzo[a]pyrene (3-OH-BP) and hydrolysis of styrene oxide were increased 1.5- and 1.4-fold, respectively. Benzo(a)pyrene 41-55 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-16 3579981-4 1987 The fluorographic pattern of the protein labeling was cytochrome P-450-dependent, as was demonstrated by CO and metyrapone inhibition as well as by pretreatment of rats with inducing drugs such as 3-methylcholanthrene, benzo(a)pyrene, phenobarbitone and Aroclor 1254. Benzo(a)pyrene 219-233 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 54-70 3498153-5 1987 The increased binding of [3H]BP to liver DNA of rats fed the high level of menhaden oil may be due, in part, to increases in the MFO responsible for BP activation (as suggested by increased cytochrome P-450 level and total BP hydroxylase activity). Benzo(a)pyrene 29-31 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 190-206 3707619-8 1986 These results suggest that CHP-dependent metabolism of BP is selectively mediated by constitutive cytochrome P-450 isozyme(s) and that two forms of BP binding sites exist in cytochrome P-450 isozymes and are responsible for the hydroxylation of BP at C-3 and C-6. Benzo(a)pyrene 55-57 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 98-114 3707619-8 1986 These results suggest that CHP-dependent metabolism of BP is selectively mediated by constitutive cytochrome P-450 isozyme(s) and that two forms of BP binding sites exist in cytochrome P-450 isozymes and are responsible for the hydroxylation of BP at C-3 and C-6. Benzo(a)pyrene 148-150 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 174-190 3707619-8 1986 These results suggest that CHP-dependent metabolism of BP is selectively mediated by constitutive cytochrome P-450 isozyme(s) and that two forms of BP binding sites exist in cytochrome P-450 isozymes and are responsible for the hydroxylation of BP at C-3 and C-6. Benzo(a)pyrene 148-150 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 174-190 2423085-3 1986 The diversion of electrons from cytochrome P-450 enzymes results in a large decrease in the percent of benzo(a)pyrene metabolized by rat liver microsomes as measured by HPLC. Benzo(a)pyrene 103-117 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 32-48 3875401-6 1985 Since various cytochrome P-450 isozymes catalyze the oxidative attack on the benzo(a)pyrene molecule at defined preferential sites, this analysis also provides an indirect trace of potential differences in the pattern of cytochrome P-450 isozymes present in the individual membranes. Benzo(a)pyrene 77-91 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 14-30 3875401-6 1985 Since various cytochrome P-450 isozymes catalyze the oxidative attack on the benzo(a)pyrene molecule at defined preferential sites, this analysis also provides an indirect trace of potential differences in the pattern of cytochrome P-450 isozymes present in the individual membranes. Benzo(a)pyrene 77-91 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 221-237 4085395-0 1985 [Specificity of cytochrome P-450 isoforms contained in endoplasmic reticulum membranes and nuclear membranes in relation to benzo(a)pyrene]. Benzo(a)pyrene 124-138 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 16-32 3839642-0 1985 Cytochrome P-450-catalyzed stereoselective epoxidation at the K region of benz[a]anthracene and benzo[a]pyrene. Benzo(a)pyrene 96-110 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-16 3839642-4 1985 The results indicate that various cytochrome P-450 isozymes of rat liver exhibit different stereoselective properties in catalyzing the epoxidation reactions at the K region of BA and of BP. Benzo(a)pyrene 187-189 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 34-50 3928617-7 1985 On the other hand, the activities for the oxidations of benzo[a]pyrene, 7-ethoxycoumarin, biphenyl, and estradiol-17 beta varied greatly among the forms of cytochrome P-450. Benzo(a)pyrene 56-70 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 156-172 4070009-5 1985 Benzo[a]pyrene induced its own metabolism by a slightly greater amount in the vitamin-sufficient rats, but it was not to the level of the deficient group, although the levels of cytochrome P450 were still below those of the deficient rats. Benzo(a)pyrene 0-14 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 178-193 4070009-6 1985 In discussing lung microsomes, benzo[a]pyrene pre-treatment of deficient rats resulted in slightly elevated levels of cytochrome P450 and a slightly greater rate of metabolism of benzo[a]pyrene compared with rats fed the complete diet. Benzo(a)pyrene 31-45 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 118-133 4085395-2 1985 Several forms of cytochrome P-450 are supposed to participate in metabolic conversion of BP. Benzo(a)pyrene 89-91 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 17-33 6435901-0 1984 Binding and metabolism of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene by seven purified forms of cytochrome P-450. Benzo(a)pyrene 26-40 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 103-119 6436235-1 1984 Distinctive features of cytochrome P-450 involved in the activation of aflatoxin B1 and benzo(a)pyrene. Benzo(a)pyrene 88-102 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 24-40 6435901-2 1984 The major 3-methylcholanthrene (MC) inducible cytochrome P-450 (form c) exhibits the greatest activity toward both benzo[a]pyrene (BP) (58 min-1) and 7,12-dimethylbenz[a]anthracene (DMBA) (29 min-1) and forms substantially high spin, high affinity complexes (Kd = 10 nM) with both hydrocarbons. Benzo(a)pyrene 115-129 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 46-62 6435901-2 1984 The major 3-methylcholanthrene (MC) inducible cytochrome P-450 (form c) exhibits the greatest activity toward both benzo[a]pyrene (BP) (58 min-1) and 7,12-dimethylbenz[a]anthracene (DMBA) (29 min-1) and forms substantially high spin, high affinity complexes (Kd = 10 nM) with both hydrocarbons. Benzo(a)pyrene 131-133 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 46-62 6487578-12 1984 It is proposed that a self-catalyzed inhibition (suicide inhibition) of the cytochrome P-450 dependent BP hydroxylation occurs in the presence of EP. Benzo(a)pyrene 103-105 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 76-92 6487785-3 1984 Addition of the free radical scavenger 1,2,3-trioxybenzene and the monoxygenase substrate 3,4-benzo(a)pyrene to the incubation medium induces inhibition of LPO and simultaneous stabilization of cytochrome P-450. Benzo(a)pyrene 90-108 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 194-210 6430544-8 1984 Among four forms of cytochrome P-450 examined, an isozyme P-448-IId which showed high activity in hydroxylation of benzo(a)pyrene catalyzed most efficiently the reduction of 1-nitropyrene. Benzo(a)pyrene 115-129 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 20-36 6089701-6 1984 Inhaled DBP decreased in a dose-dependent way the lung microsomal concentration of cytochrome P-450 by as much as 63%, which was reflected in a significant reduction of the microsomal metabolism of n-hexane and benzo(a)pyrene in the 7.0 ppm group. Benzo(a)pyrene 211-225 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 83-99 6314905-0 1983 Differential metabolism of acetanilide versus ethoxycoumarin and benzo[a]pyrene by two 3-methylcholanthrene-inducible forms of rat liver cytochrome P-450. Benzo(a)pyrene 65-79 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 137-153 6327095-0 1984 Covalent binding of benzo[a]pyrene to cytochrome P-450 beta NF-B2 and other proteins in reconstituted mixed-function oxidase systems. Benzo(a)pyrene 20-34 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 38-54 6327095-1 1984 A reconstituted mixed-function oxidase system, containing the major beta-naphthoflavone-induced isozyme of rat liver cytochrome P-450 bound benzo[a]pyrene covalently in the presence of NADPH. Benzo(a)pyrene 140-154 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 117-133 6327095-5 1984 Approximately 6 molecules of benzo[a]pyrene bound to each molecule cytochrome P-450 during prolonged incubations. Benzo(a)pyrene 29-43 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 67-83 6327095-6 1984 No binding occurred when the beta-naphthoflavone-induced isozyme of cytochrome P-450 was replaced by the major isozyme induced by phenobarbital, but both cytochromes incorporated benzo[a]pyrene to approximately the same extent when they were incubated together in the presence of the reductase and NADPH. Benzo(a)pyrene 179-193 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 68-84 6326392-1 1984 The mechanistic plurality of the microsomal cytochrome P-450 enzyme system is illustrated by studies of the oxidative metabolism of benzo[a]pyrene, 3-hydroxybenzo[a]pyrene and arachidonic acid. Benzo(a)pyrene 132-146 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 44-60 6282475-1 1982 NADPH-reduction of benzo[a]pyrene 4,5-oxide (BP-4,5-oxide) to BP required four components from rat liver: cytochrome P-450, NADPH cytochrome P-450 reductase, phosphatidylcholine and a soluble, heat-sensitive factor which was present in 105 000 X g supernatant and was also released from microsomes by sonication. Benzo(a)pyrene 45-47 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 106-122 6303564-6 1983 Amounts of BP diol-epoxide I-derived tetrols formed from BP-7,8-diol by the prostaglandin synthetase-dependent and the cytochrome P-450-dependent pathways varied significantly between the two pulmonary cell fractions examined. Benzo(a)pyrene 11-13 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 119-135 6622818-2 1983 Pretreatment of rats with 3,4-benzpyrene or phenobarbital increased the liver microsomal concentration of cytochrome P-450 (448) and the rate of aminopyrine and p-nitroanisole demethylation and of aniline hydroxylation whereas pretreatment cytochrome P-450 depressor agents such as cadmium or cobalt lowered the concentration of the hemoprotein and decreased the rate of the demethylation reactions. Benzo(a)pyrene 26-40 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 106-122 6622818-2 1983 Pretreatment of rats with 3,4-benzpyrene or phenobarbital increased the liver microsomal concentration of cytochrome P-450 (448) and the rate of aminopyrine and p-nitroanisole demethylation and of aniline hydroxylation whereas pretreatment cytochrome P-450 depressor agents such as cadmium or cobalt lowered the concentration of the hemoprotein and decreased the rate of the demethylation reactions. Benzo(a)pyrene 26-40 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 240-256 6800653-2 1982 Both 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene, which also is a well-known carcinogen but has no short-term effects on rat adrenals, appear to be metabolized by one common type of cytochrome P-450-dependent monooxygenase localized in the endoplasmic reticulum. Benzo(a)pyrene 40-54 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 188-204 6305488-0 1983 Immunochemical study on the contributions of two molecular species of microsomal cytochrome P-450 to the metabolism of benzo(a)pyrene by rat liver microsomes. Benzo(a)pyrene 119-133 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 81-97 6305488-2 1983 Benzo(a)pyrene was incubated with polychlorinated biphenyl-treated rat liver microsomes, in which PB-P-450 and MC-P-448 constituted about 45 and 24% of the total cytochrome P-450, respectively. Benzo(a)pyrene 0-14 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 162-178 6830852-1 1983 Cytochrome P-450 substrate interactions were studied with cytochrome P-450 partially purified from livers of untreated, phenobarbital-treated, benzo[a]pyrene-treated and caffeine-treated rats. Benzo(a)pyrene 143-157 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-16 6295661-0 1983 Specificity of rat liver cytochrome P-450 isozymes in the mutagenic activation of benzo[a]pyrene, aromatic amines and aflatoxin B1. Benzo(a)pyrene 82-96 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 25-41 7127220-7 1982 These differences in IC50 values indicated that the predominant form(s) of cytochrome P-450 that hydroxylate benzo(a)pyrene varied with the age, hormonal, and induced status of the animal. Benzo(a)pyrene 109-123 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 75-91 6288047-4 1982 RJ inhibited the microsomal oxidation of substrates of cytochrome P-450 (aniline, aminopyrine and benzo [a]pyrene). Benzo(a)pyrene 98-113 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 55-71 6279326-7 1982 The total metabolism of BP was found to be approximately 20-fold greater with the cytochrome P-450 from the 3-methylcholanthrene (P-450 3-MC) and beta-naphthoflavone (P-450 BNF) treated rats than with the phenobarbital preinduced cytochrome P-450 (P-450 BP). Benzo(a)pyrene 24-26 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 82-98 6279326-7 1982 The total metabolism of BP was found to be approximately 20-fold greater with the cytochrome P-450 from the 3-methylcholanthrene (P-450 3-MC) and beta-naphthoflavone (P-450 BNF) treated rats than with the phenobarbital preinduced cytochrome P-450 (P-450 BP). Benzo(a)pyrene 24-26 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 230-246 413503-0 1977 The effects of phenobarbital and 3,4-benzypyrene on microsomal cytochrome P-450 and NADPH-cytochrome C reductase in regenerating rat liver after partial hepatectomy or chemical injury. Benzo(a)pyrene 33-48 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 63-79 6450647-0 1981 Competition between benzo[a]pyrene and various steroids for cytochrome P-450-dependent rat liver monooxygenases. Benzo(a)pyrene 20-34 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 60-76 6270846-3 1980 Similar absorption characteristics of cytochrome P-450 and turnover rates for BP on the basis o f cytochrome P-450 was observed among the different microsomal preparations. Benzo(a)pyrene 78-80 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 98-114 118169-4 1979 In reconstituted systems containing the purified cytochrome and NADPH-cytochrome P-450 reductase, ethoxycoumarin deethylation and benzo(a)pyrene hydroxylation catalyzed by cytochrome P-450 and P-448 were completely inhibited by the homologous antibody, while essentially no effect was observed with heterologous conbinations of antigen and antibody. Benzo(a)pyrene 130-144 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 172-198 522515-2 1979 Isolated intestinal cells catalyzed the cytochrome P-450 dependent metabolism of benzo(a)pyrene, harmine, ethoxyresorufin and ethoxycoumarin. Benzo(a)pyrene 81-95 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 40-56 6793028-6 1981 Changes in the in vitro formation of benzo(a)pyrene metabolites were found to correlate with changes in the multiple forms of cytochrome P-450. Benzo(a)pyrene 37-51 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 126-142 821945-4 1976 Highly purified cytochrome P-450 from phenobarbital-treated rats is relatively poor in catalyzing the formation of mutagenic metabolites from benzo (a)pyrene. Benzo(a)pyrene 142-157 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 16-32 21783461-3 2005 Several hydroxylated metabolites of benzo[a]pyrene (BaP) and chrysene (CHN) were formed by rat liver microsomal cytochrome P450 (CYP) activity, some of which possess estrogenic activity. Benzo(a)pyrene 36-50 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 112-127 813227-10 1976 When CO was bubbled through the reaction mixture with or without added NADPH, binding of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene was partially inhibited, indicating that cytochrome P-450 plays a role in this activation. Benzo(a)pyrene 89-103 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 180-196 28263535-4 2016 METHODS: Changes in CYP protein expression after exposure of rats to BaP, EE2 or estradiol were analyzed by Western blotting. Benzo(a)pyrene 69-72 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 20-23 28263535-6 2016 RESULTS: Whereas exposure to BaP induces expression of CYP1A1 protein and its marker activity (Sudan I oxidation) in liver, kidney and lung of rats, no significant induction of this CYP and its enzyme activity was produced by EE2 and estradiol. Benzo(a)pyrene 29-32 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 55-58 19889059-0 2009 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Benzo(a)pyrene 25-39 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 57-72 21783461-3 2005 Several hydroxylated metabolites of benzo[a]pyrene (BaP) and chrysene (CHN) were formed by rat liver microsomal cytochrome P450 (CYP) activity, some of which possess estrogenic activity. Benzo(a)pyrene 36-50 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 129-132 21783461-3 2005 Several hydroxylated metabolites of benzo[a]pyrene (BaP) and chrysene (CHN) were formed by rat liver microsomal cytochrome P450 (CYP) activity, some of which possess estrogenic activity. Benzo(a)pyrene 52-55 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 112-127 21783461-3 2005 Several hydroxylated metabolites of benzo[a]pyrene (BaP) and chrysene (CHN) were formed by rat liver microsomal cytochrome P450 (CYP) activity, some of which possess estrogenic activity. Benzo(a)pyrene 52-55 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 129-132 11588892-1 2001 Monoclonal antibody (MAb) 1-7-1 against 3-methylcholanthrene (MC)-induced forms of cytochrome P-450 (CYP) was used to characterize benzo[a]pyrene (B[a]P) metabolism in rat liver and extrahepatic tissues and its modulation by phenolic antioxidants, propyl and octyl gallates. Benzo(a)pyrene 131-145 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 83-99 9555654-2 1998 Because cytochrome P-450-dependent arachidonate metabolites participate in the regulation of renal sodium transport and BP, this study tested the hypothesis that these renal responses to acute hypertension would be prevented if cytochrome P-450 metabolism were inhibited by cobalt chloride (CoCl2). Benzo(a)pyrene 120-122 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 8-24 9555654-2 1998 Because cytochrome P-450-dependent arachidonate metabolites participate in the regulation of renal sodium transport and BP, this study tested the hypothesis that these renal responses to acute hypertension would be prevented if cytochrome P-450 metabolism were inhibited by cobalt chloride (CoCl2). Benzo(a)pyrene 120-122 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 228-244