PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
4039566-4	1985	When the observed rates of 7,8 and 9,10 diol formation per nmole P450 for chow-fed animals are plotted vs. the b5/P450 ratio a positive correlation was observed suggesting that cytochrome b5 participates directly in the microsomal metabolism of benzo(a)pyrene.	Benzo(a)pyrene	245-259	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	114-118	
8771373-5	1996	Both AF and BP are substrates for the P-450 and flavin-containing monooxygenase enzyme system, which can be induced with beta-naphthoflavone (beta NF).	Benzo(a)pyrene	12-14	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	38-79	
2134689-5	1990	The P-450 catalyzed benzo[a]pyrene and tolbutamide hydroxylations and cyclophosphamide oxidation, but showed low activity for the mutagenic activation of IQ (2-amino-3-methylimidazo [4, 5-f]quinoline).	Benzo(a)pyrene	20-34	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	4-9	
16769251-7	2006	The metabolism of many exogenous compounds including benzo(a)pyrene (BaP), pyrene, ethoxyresorufin, ethoxycoumarin and aniline is mediated by P450 enzymes in tissues of marine invertebrates.	Benzo(a)pyrene	53-67	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	142-146	
16769251-7	2006	The metabolism of many exogenous compounds including benzo(a)pyrene (BaP), pyrene, ethoxyresorufin, ethoxycoumarin and aniline is mediated by P450 enzymes in tissues of marine invertebrates.	Benzo(a)pyrene	69-72	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	142-146	
2791199-0	1989	Relative contribution of various forms of cytochrome P450 to the metabolism of benzo[a]pyrene by human liver microsomes.	Benzo(a)pyrene	79-93	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	53-57	
2791199-1	1989	A variety of cytochromes P450 have been implicated in the hepatic metabolism of benzo[a]pyrene (BP), including forms that are constitutively expressed and those that are highly inducible.	Benzo(a)pyrene	80-94	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	25-29	
2791199-1	1989	A variety of cytochromes P450 have been implicated in the hepatic metabolism of benzo[a]pyrene (BP), including forms that are constitutively expressed and those that are highly inducible.	Benzo(a)pyrene	96-98	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	25-29	
2791199-2	1989	In the present study the metabolism of BP to organic solvent-soluble derivatives by eight forms of cytochrome P450 isolated from rat liver and by a series of 11 human liver microsomal samples was investigated.	Benzo(a)pyrene	39-41	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	110-114	
2791199-7	1989	Of six different antibodies to forms of rat liver P450 tested, only those to P450s MC1a (P450IA2), MC1b (P450IA1) and UT1 (P450IIA1) consistently inhibited BP metabolism.	Benzo(a)pyrene	156-158	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	50-54	
2791199-9	1989	An antibody to cytochrome P450 PB3a (P450IIB1) did, however, inhibit the formation of metabolites at the 4,5- and 9,10-positions of BP by microsomal fractions of livers from one individual who had been receiving the drug phenytoin.	Benzo(a)pyrene	132-134	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	26-30	
2791199-10	1989	These data indicate that several forms of P450 in human liver are involved in the metabolism of BP and that both constitutively expressed as well as inducible forms are important in its disposition in man.	Benzo(a)pyrene	96-98	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	42-46	
3185539-3	1988	Microsomal oxidation of P450 substrates aminopyrine and benz(a) pyrene is inhibited by the 1-naphtoxyalcanthiols studied.	Benzo(a)pyrene	56-70	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	24-28	
33249052-9	2021	Mixtures containing BP caused a strong decrease of CAR transactivation in line with lower CYP2B6 expression.	Benzo(a)pyrene	20-22	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	90-96	
4650614-1	1972	V. Competition between cytochromes P-450 and P-448 for reductase in 3,4-benzpyrene hydroxylation.	Benzo(a)pyrene	68-82	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	35-64	
25616378-1	2015	Benzo[a]pyrene-7,8-dione (BPQ) is formed by the activation of benzo[a]pyrene(B[a]P), which is an environmental toxic substance that is easily exposed in daily life, due to P450/epoxide hydrolase, and is a substance that induces DNA deformation by forming adducts with DNA.	Benzo(a)pyrene	62-76	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	172-176