PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28247504-3	2017	Co-treatment with 5 microM BaP and 20 microM EGCG in BEAS-2B promoted a significant reduction in cell viability and greater G2/M cell cycle arrest, induction of ROS, and reductions in BaP-induced CYP1A1/CYP1B1/COMT, EGFR, p-Akt (Ser473), p-p53 (Thr55), and survivin mRNA/protein expression, as well as an increase in p-p53 (Ser15).	Benzo(a)pyrene	27-30	catechol-O-methyltransferase	Homo sapiens	210-214	
19578924-1	2009	The COMT gene is considered as one of the prominent candidate genes for susceptibility to BP, and most studies focused a functional polymorphism in the gene: the Val/Met polymorphism (rs4680).	Benzo(a)pyrene	90-92	catechol-O-methyltransferase	Homo sapiens	4-8	
19578924-10	2009	In conclusion, the low-activity allele (Met) of rs4680 in COMT gene possibly confers risk for bipolar disorder in the Han population, while it needs further evidence for concluding its association with BP in the Caucasian population.	Benzo(a)pyrene	202-204	catechol-O-methyltransferase	Homo sapiens	58-62	
17198907-5	2007	METHODS: In the 1995-97 Nord-Trondelag Health Study (HUNT), the association between Val/Met polymorphism at the COMT gene and BP was evaluated in a group of 2966 nondiabetic individuals.	Benzo(a)pyrene	126-128	catechol-O-methyltransferase	Homo sapiens	112-116	
6272977-1	1981	These studies suggest that the microsomal metabolism of benzo(a)pyrene (BP) produces metabolites which can be methylated by the catechol-o-methyltransferase (COMT)/S-adenosylmethionine (SAM) enzyme/donor combination.	Benzo(a)pyrene	56-70	catechol-O-methyltransferase	Homo sapiens	128-156	
6272977-1	1981	These studies suggest that the microsomal metabolism of benzo(a)pyrene (BP) produces metabolites which can be methylated by the catechol-o-methyltransferase (COMT)/S-adenosylmethionine (SAM) enzyme/donor combination.	Benzo(a)pyrene	56-70	catechol-O-methyltransferase	Homo sapiens	158-162	
6272977-1	1981	These studies suggest that the microsomal metabolism of benzo(a)pyrene (BP) produces metabolites which can be methylated by the catechol-o-methyltransferase (COMT)/S-adenosylmethionine (SAM) enzyme/donor combination.	Benzo(a)pyrene	72-74	catechol-O-methyltransferase	Homo sapiens	128-156	
6272977-1	1981	These studies suggest that the microsomal metabolism of benzo(a)pyrene (BP) produces metabolites which can be methylated by the catechol-o-methyltransferase (COMT)/S-adenosylmethionine (SAM) enzyme/donor combination.	Benzo(a)pyrene	72-74	catechol-O-methyltransferase	Homo sapiens	158-162	
6272977-3	1981	Approximately 0.06% of substrate BP was recovered as COMT/SAM-reactive substances.	Benzo(a)pyrene	33-35	catechol-O-methyltransferase	Homo sapiens	53-57	
6272977-5	1981	Organic extracts of COMT/[14C]SAM incubations with BP were fractionated by high-performance liquid chromatography.	Benzo(a)pyrene	51-53	catechol-O-methyltransferase	Homo sapiens	20-24	
6272977-7	1981	When the Ames mutagenesis assay was supplemented with COMT/SAM, a 36% reduction was observed in the number of revertant colonies induced by the microsomal oxidation of BP.	Benzo(a)pyrene	168-170	catechol-O-methyltransferase	Homo sapiens	54-58	
21920623-8	2012	Benzo[a]pyrene increased expression of CYP1B1 over CYP1A1 and suppressed estrogen-induced COMT up-regulation in ERalpha(-) tumor cells, probably switching estrogen metabolism to 4-hydroxyestradiol formation and removing the inhibition of 2-methoxyestradiol on ERalpha(-) tumors.	Benzo(a)pyrene	0-14	catechol-O-methyltransferase	Homo sapiens	90-94	
25753458-7	2015	We used a regression model to evaluate the effect of COMT genotype on the BP in the striatum and its sub-regions.	Benzo(a)pyrene	74-76	catechol-O-methyltransferase	Homo sapiens	53-57