PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3996731-0	1985	The homogeneity of rat liver microsomal cytochrome P-448 activity and its role in the activation of benzo[a]pyrene to mutagens.	Benzo(a)pyrene	100-114	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	40-56	
22785257-2	2012	Inhibition studies and kinetic analyses confirmed literature data indicating that methoxyresorufin is a specific CYP1A2 substrate in both uninduced and BaP-treated rats, whereas ethoxyresorufin is a specific CYP1A1 substrate only in BaP-treated rats.	Benzo(a)pyrene	152-155	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	113-119	
15822860-6	2005	The acceleration of two enzymatic reactions may contribute to the rapid elimination of BP; the first step, the formation of a metabolic intermediate (which is mutagenic) by CYP1A2 and the second, the conjugation of active metabolic intermediates by UGT.	Benzo(a)pyrene	87-89	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	173-179	
2096947-1	1990	Antibodies to mouse liver cytochrome P3-450 (anti-P3-450) and antibodies to rat liver cytochrome P-450d (anti-P-450d-c) inhibit the 0-deethylation of 7-ethoxyresorufin (ER) in liver microsomes of benz(a)pyrene-induced (BP) mice but do not inhibit the 0-deethylase activity in liver microsomes of BP-induced rats.	Benzo(a)pyrene	219-221	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	86-103	
2096947-1	1990	Antibodies to mouse liver cytochrome P3-450 (anti-P3-450) and antibodies to rat liver cytochrome P-450d (anti-P-450d-c) inhibit the 0-deethylation of 7-ethoxyresorufin (ER) in liver microsomes of benz(a)pyrene-induced (BP) mice but do not inhibit the 0-deethylase activity in liver microsomes of BP-induced rats.	Benzo(a)pyrene	296-298	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	86-103	
2275212-2	1990	Antibodies to mouse liver cytochrome P3-450 (anti-P3-450) and antibodies to rat liver cytochrome P-450d (anti-P-450d-c) both inhibit the O-deethylation of 7-ethoxy-resorufin (ER) in liver microsomes of benzo(a)pyrene-induced (BP) mice but do not inhibit the O-deethylase activity in liver microsomes of BP-induced rats.	Benzo(a)pyrene	226-228	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	86-103	
2275212-2	1990	Antibodies to mouse liver cytochrome P3-450 (anti-P3-450) and antibodies to rat liver cytochrome P-450d (anti-P-450d-c) both inhibit the O-deethylation of 7-ethoxy-resorufin (ER) in liver microsomes of benzo(a)pyrene-induced (BP) mice but do not inhibit the O-deethylase activity in liver microsomes of BP-induced rats.	Benzo(a)pyrene	303-305	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	86-103	
3335003-8	1988	The addition of anti-cytochrome P-448 antibody or the cofactors for UDP glucuronyl transferase and glutathione-S-transferase to the liver S-9 preincubation mixture with BP caused a marked decrease in BP mutagenicity when liver S-9 fractions from Sudan III-treated rats were used.	Benzo(a)pyrene	169-171	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	21-37	
3335003-8	1988	The addition of anti-cytochrome P-448 antibody or the cofactors for UDP glucuronyl transferase and glutathione-S-transferase to the liver S-9 preincubation mixture with BP caused a marked decrease in BP mutagenicity when liver S-9 fractions from Sudan III-treated rats were used.	Benzo(a)pyrene	200-202	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	21-37	
11682644-8	2001	When tested in the Ames test, Aroclor S9 and PB/NF S9 were the most effective in the activation of benzo[a]pyrene and 3-methylcholanthrene which are metabolized mainly by CYP1A1; additionally, the highest mutagenic potency of 2-aminofluorene and N-nitrosodipropylamine, which are activated by CYP1A2 and CYP2B, respectively, were obtained with PB/NF S9.	Benzo(a)pyrene	99-113	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	293-299	
7603785-8	1995	These results indicate, for the first time, that neonatal BaP exposure results in gender-specific lasting effects on hepatic cytochrome P450 1A2, cytochrome P450 2C11, and glucocorticoid receptors in adult male rats, whereas these parameters are unchanged in adult female rats.	Benzo(a)pyrene	58-61	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	125-144	
4063404-5	1985	The mode of inhibition of various substrates metabolism by antibodies in neonatal rat microsomes suggests that the 3-methylcholantrene-induced cytochrome P-448, like in adult rats, participates in the hydroxylation of benz(a)pyrene and O-deethylation of 7-etoxyresorufin.	Benzo(a)pyrene	218-231	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	143-159	
3996731-2	1985	An excellent direct correlation (r = 0.95) has been observed between ethoxyresorufin O-deethylase and the metabolic activation of benzo[a]pyrene to mutagens when the fraction of cytochromes P-450 present as cytochrome P-448 was altered by the administration of phenobarbitone and 3-methylcholanthrene alone or in combination with 9-hydroxyellipticine.	Benzo(a)pyrene	130-144	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	207-223	
6437454-3	1984	Using antibodies against cytochrome P-448, the cytochrome P-448 content in native and reconstituted microsomal membranes and its participation in hydroxylation of benz(a)pyrene was determined.	Benzo(a)pyrene	163-176	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	47-63	
6087804-4	1984	Administration of very small doses of benzo[a]pyrene (50 micrograms/kg) to rats to induce cytochrome P-448 specifically increased only the O-de-ethylation of ethoxyresorufin.	Benzo(a)pyrene	38-52	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	90-106	
6437454-4	1984	It was shown that benz(a)pyrene is hydroxylated in a membrane microsomal monooxygenase system more effectively, when the ratio of NADPH-cytochrome P-450 reductase to cytochrome P-448 is 1: 3 to 1: 6.	Benzo(a)pyrene	18-31	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	166-182	
6792366-5	1981	In the presence of NADPH-cytochrome c reductase, lipid and NADPH, the pulmonary cytochrome P-448 was active in hydroxylation of benzo-[a]pyrene, but catalyzed N-demethylation of benzphetamine in a slow rate.	Benzo(a)pyrene	128-143	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	80-96	
6326866-1	1984	Using antibodies against electrophoretically homogeneous cytochrome P-448 from rat liver microsomes induced by 3-methylcholanthrene, the changes in the immunologic identity and contents by cytochrome P-448 induced by 3-methylcholanthrene, 3.4-benzpyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), were studied.	Benzo(a)pyrene	239-253	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	189-205	
6326866-4	1984	On the other hand, 3-methylcholanthrene, 3,4-benzpyrene and TCDD significantly and equally activates the cytochrome P-448-dependent benzpyrene hydroxylase, since the antibodies against cytochrome P-448 inhibit benzpyrene metabolism in the microsomes by 85-90%.	Benzo(a)pyrene	41-55	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	105-121	
6326866-4	1984	On the other hand, 3-methylcholanthrene, 3,4-benzpyrene and TCDD significantly and equally activates the cytochrome P-448-dependent benzpyrene hydroxylase, since the antibodies against cytochrome P-448 inhibit benzpyrene metabolism in the microsomes by 85-90%.	Benzo(a)pyrene	41-55	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	185-201	
6326866-5	1984	The possible reasons for the TCDD-induced increase in the catalytic activity of cytochrome P-448 as compared to the immunologically identical cytochrome P-448 induced by 3-methylcholanthrene and 3,4-benzpyrene, are discussed.	Benzo(a)pyrene	195-209	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	80-96	
6326866-5	1984	The possible reasons for the TCDD-induced increase in the catalytic activity of cytochrome P-448 as compared to the immunologically identical cytochrome P-448 induced by 3-methylcholanthrene and 3,4-benzpyrene, are discussed.	Benzo(a)pyrene	195-209	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	142-158	
6326393-16	1984	Equilibrium gel filtration analysis of the number of benzo[a]pyrene binding sites per mole of enzyme monomer showed a value of 1 for purified yeast cytochrome P-448 and 6 for this enzyme in microsomal form.	Benzo(a)pyrene	53-67	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	148-164	
6326393-18	1984	However, purified cytochrome P-448 from beta-naphthoflavone-induced rats gave a value of 6 benzo[a]pyrene binding sites.	Benzo(a)pyrene	91-105	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	18-34	
6326393-19	1984	Type I binding spectra with purified yeast cytochrome P-448 were observed with benzo[a]pyrene, lanosterol, ethylmorphine, dimethylnitrosamine, sodium phenobarbitone and perhydrofluorene.	Benzo(a)pyrene	79-93	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	43-59	
6295661-4	1983	However, only cytochrome P-448(55) metabolizes benzo[a]pyrene and its 7,8-dihydrodiol derivative to mutagenic products.	Benzo(a)pyrene	47-61	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	14-30	
7126636-6	1982	Purified cytochromes P-448 from 3-methylcholanthrene-treated rat had similar spectral properties and activity towards [14C]benzo[a]pyrene suggesting similarities between these forms.	Benzo(a)pyrene	123-137	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	21-26	
7172416-1	1982	Administration of a single dose of the inhibitor of the hepatic mixed function oxidases, 9-hydroxyellipticine (9-OHE), resulted in a marked increase in the cytochrome P-448 catalysed activities of ethoxyresorufin O-deethylase, biphenyl 2-hydroxylase and activation of benzo[a]pyrene to mutagens.	Benzo(a)pyrene	268-282	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	156-172	
6191918-4	1983	The two P-448 forms had similar spectral properties, substrate specificity, sensitivity to inhibitors and regioselectivity in the metabolism of benzo(a)pyrene and testosterone.	Benzo(a)pyrene	144-158	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	8-13	
856576-1	1977	Inhibition by CO of benzo[a]pyrene hydroxylation was studied in hepatic microsomes from rats pretreated with phenobarbital, 3-methylcholanthrene or 2,3,7,8-tetrachlorodibenzo-p-dioxin, from animals treated with vehicle (saline or corn oil, respectively), and in a reconstituted microsomal cytochrome P-448 system prepared from rats treated with 3-methylcholanthrene.	Benzo(a)pyrene	20-34	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	300-305	
821945-9	1976	The number of mutations induced per nmol of hemoprotein is approximately 3- to 4-fold higher when trans-7,8-dihydroxy-7,8-dihydrobenzo (a)pyrene replaces benzo (a)pyrene as a substrate for the cytochrome P-448-dependent monooxygenase system.	Benzo(a)pyrene	129-144	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	193-209	
33213213-2	2020	The toxicity of PAHs, which include benzo(alpha)pyrene (BP), is mediated by the activation of R450 cytochromes of the 1A subfamily (CYP1A1 and CYP1A2).	Benzo(a)pyrene	56-58	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	143-149	
815258-9	1976	When added to the reconstituted system, the cytochrome P-448 antibody inhibits purified rat cytochrome P-448- and P-450-supported N-demethylation of benzphetamine, O-deethylation of ethoxycoumarin, hydroxylation of benzo[a]pyrene, and the hydroxylation of testosterone at the 6beta, 7alpha, and 16alpha positions.	Benzo(a)pyrene	215-229	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	44-60	
27167070-4	2016	Here we show that menadione (a water-soluble analog of vitamin K3) inhibits BP-induced expression and enzymatic activity of both CYP1A1 and CYP1A2 in vivo (in the rat liver) and BP-induced activity of CYP1A1 in vitro.	Benzo(a)pyrene	76-78	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	140-146	
26466350-3	2015	Inhibition of dopamine D2-receptors with sulpiride (SULP) significantly repressed the constitutive and benzo[a]pyrene (B[a]P)-induced CYP1A1, CYP1A2 and CYP1B expression in the rat liver.	Benzo(a)pyrene	103-117	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	142-148	
26466350-3	2015	Inhibition of dopamine D2-receptors with sulpiride (SULP) significantly repressed the constitutive and benzo[a]pyrene (B[a]P)-induced CYP1A1, CYP1A2 and CYP1B expression in the rat liver.	Benzo(a)pyrene	119-124	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	142-148