PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25228686-2 2014 Here, we have evaluated a potential role of WRN (mutated in Werner syndrome) and RECQ1 (the most abundant homolog of WRN) in hydroquinone (HQ)- and benzo[a]pyrene (BaP)-induced genotoxicity. Benzo(a)pyrene 164-167 WRN RecQ like helicase Homo sapiens 44-47 25228686-3 2014 Silencing of WRN or RECQ1 expression in HeLa cells increased their sensitivity to HQ and BaP but elicited distinct DNA damage response. Benzo(a)pyrene 89-92 WRN RecQ like helicase Homo sapiens 13-16 25228686-6 2014 Notably, loss of WRN in RECQ1-depleted cells ameliorated BaP toxicity. Benzo(a)pyrene 57-60 WRN RecQ like helicase Homo sapiens 17-20 25228686-7 2014 Collectively, our results provide first indication of nonredundant participation of WRN and RECQ1 in protection from the potentially carcinogenic effects of BaP and HQ. Benzo(a)pyrene 157-160 WRN RecQ like helicase Homo sapiens 84-87 16380375-3 2006 The results demonstrate that WRN helicase activity is inhibited in a strand-specific manner by BaP DE-dG adducts only when on the translocating strand. Benzo(a)pyrene 95-98 WRN RecQ like helicase Homo sapiens 29-32