PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15792794-0 2005 ERK-dependent induction of TNFalpha expression by the environmental contaminant benzo(a)pyrene in primary human macrophages. Benzo(a)pyrene 80-94 mitogen-activated protein kinase 1 Homo sapiens 0-3 18448277-0 2008 Benzo(a)pyrene-caused increased G1-S transition requires the activation of c-Jun through p53-dependent PI-3K/Akt/ERK pathway in human embryo lung fibroblasts. Benzo(a)pyrene 0-14 mitogen-activated protein kinase 1 Homo sapiens 113-116 18406507-0 2008 MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: involvement of p53 phosphorylation and acetylation. Benzo(a)pyrene 50-64 mitogen-activated protein kinase 1 Homo sapiens 0-4 16600107-11 2006 CONCLUSION: ERK and JNK, but not p38, mediated benzo(a)pyrene-induced cell cycle changes by AP-1 transactivation in HELF. Benzo(a)pyrene 47-61 mitogen-activated protein kinase 1 Homo sapiens 12-15 17959047-1 2007 OBJECTIVE: To study the effects of benzo(a)pyrene (BaP) on the cell cycle distribution and activities of mitogen-activated protein kinase (MAPK) signal molecules (ERK1/2, JNK1/2 and p38) in human embryo lung cells (HELF), and to investigate the relationship between alterations of MAPK protein phosphorylation and the cell cycle distributions. Benzo(a)pyrene 51-54 mitogen-activated protein kinase 1 Homo sapiens 182-185 17959047-8 2007 CONCLUSION: ERK1/2, JNK1/2 and p38 could positively regulate the BaP independently induced cell cycle alterations. Benzo(a)pyrene 65-68 mitogen-activated protein kinase 1 Homo sapiens 31-34 16699726-0 2006 Benzo[a]pyrene-induced cell cycle progression is through ERKs/cyclin D1 pathway and requires the activation of JNKs and p38 mapk in human diploid lung fibroblasts. Benzo(a)pyrene 0-14 mitogen-activated protein kinase 1 Homo sapiens 120-123 12383707-6 2002 Inhibition of ERK eliminated BP-induced QR activity, whereas inhibition of p38 had no effect on QR activity. Benzo(a)pyrene 29-31 mitogen-activated protein kinase 1 Homo sapiens 14-17 15792794-7 2005 In addition, the use of chemical inhibitors of extracellular signal-regulated protein kinase (ERK) activation fully abrogated induction of TNFalpha production in BP-treated macrophages. Benzo(a)pyrene 162-164 mitogen-activated protein kinase 1 Homo sapiens 47-92 15792794-7 2005 In addition, the use of chemical inhibitors of extracellular signal-regulated protein kinase (ERK) activation fully abrogated induction of TNFalpha production in BP-treated macrophages. Benzo(a)pyrene 162-164 mitogen-activated protein kinase 1 Homo sapiens 94-97 12383707-7 2002 Treatment of cells with 10 nM BP increased [(3)H]thyd incorporation by 50% after 48 h. This increase was eliminated by ERK but not p38 inhibition. Benzo(a)pyrene 30-32 mitogen-activated protein kinase 1 Homo sapiens 119-122 12383707-8 2002 In conclusion, 10 nM BP activates ERK and p38, but only ERK contributes to BP-induced QR activity. Benzo(a)pyrene 21-23 mitogen-activated protein kinase 1 Homo sapiens 34-37 12383707-8 2002 In conclusion, 10 nM BP activates ERK and p38, but only ERK contributes to BP-induced QR activity. Benzo(a)pyrene 75-77 mitogen-activated protein kinase 1 Homo sapiens 56-59 29545172-0 2018 Benzo[a]pyrene activates an AhR/Src/ERK axis that contributes to CYP1A1 induction and stable DNA adducts formation in lung cells. Benzo(a)pyrene 0-14 mitogen-activated protein kinase 1 Homo sapiens 36-39 29805565-0 2018 Benzo(a)pyrene promotes Hep-G2 cell migration and invasion by upregulating phosphorylated extracellular signal-regulated kinase expression. Benzo(a)pyrene 0-14 mitogen-activated protein kinase 1 Homo sapiens 90-127 29805565-1 2018 Benzo(a)pyrene (BaP), a carcinogenic component of cigarette smoke, has been reported to activate extracellular signal-regulated kinase (ERK) in cancer cells. Benzo(a)pyrene 0-14 mitogen-activated protein kinase 1 Homo sapiens 97-134 29805565-1 2018 Benzo(a)pyrene (BaP), a carcinogenic component of cigarette smoke, has been reported to activate extracellular signal-regulated kinase (ERK) in cancer cells. Benzo(a)pyrene 0-14 mitogen-activated protein kinase 1 Homo sapiens 136-139 29805565-1 2018 Benzo(a)pyrene (BaP), a carcinogenic component of cigarette smoke, has been reported to activate extracellular signal-regulated kinase (ERK) in cancer cells. Benzo(a)pyrene 16-19 mitogen-activated protein kinase 1 Homo sapiens 97-134 29805565-1 2018 Benzo(a)pyrene (BaP), a carcinogenic component of cigarette smoke, has been reported to activate extracellular signal-regulated kinase (ERK) in cancer cells. Benzo(a)pyrene 16-19 mitogen-activated protein kinase 1 Homo sapiens 136-139 29805565-3 2018 Therefore, the aim of the present study was to investigate the potential role of phosphorylated (p)-ERK in BaP-induced Hep-G2 cell migration and invasion. Benzo(a)pyrene 107-110 mitogen-activated protein kinase 1 Homo sapiens 100-103 29805565-9 2018 The ERK inhibitor, U0126, was able to block the migration and invasion abilities of Hep-G2 cells induced by BaP. Benzo(a)pyrene 108-111 mitogen-activated protein kinase 1 Homo sapiens 4-7 29805565-10 2018 The results of the present study demonstrated that BaP treatment promoted the migration and invasion of Hep-G2 cells by upregulating p-ERK expression. Benzo(a)pyrene 51-54 mitogen-activated protein kinase 1 Homo sapiens 135-138 27601158-0 2016 Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc. Benzo(a)pyrene 0-14 mitogen-activated protein kinase 1 Homo sapiens 122-125 25769181-0 2015 Benzo[a]pyrene-induced cell cycle progression occurs via ERK-induced Chk1 pathway activation in human lung cancer cells. Benzo(a)pyrene 0-14 mitogen-activated protein kinase 1 Homo sapiens 57-60 25724548-0 2015 Effects of exposure to benzo[a]pyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling. Benzo(a)pyrene 23-37 mitogen-activated protein kinase 1 Homo sapiens 94-97 25724548-6 2015 Specifically, we demonstrated that benzo[a]pyrene enhances breast cancer cell migration and invasion by up-regulating ROS-induced ERK signaling, leading to the activation of matrix metalloproteinases 9. Benzo(a)pyrene 35-49 mitogen-activated protein kinase 1 Homo sapiens 130-133 25724548-7 2015 Our results suggest that benzo[a]pyrene-induced mammary gland cancer metastasis is an important and intricate process facilitated by cumulative benzo[a]pyrene exposure leading to activation of the ROS-ERK-MMP9 signaling pathway. Benzo(a)pyrene 25-39 mitogen-activated protein kinase 1 Homo sapiens 201-204 25724548-7 2015 Our results suggest that benzo[a]pyrene-induced mammary gland cancer metastasis is an important and intricate process facilitated by cumulative benzo[a]pyrene exposure leading to activation of the ROS-ERK-MMP9 signaling pathway. Benzo(a)pyrene 144-158 mitogen-activated protein kinase 1 Homo sapiens 201-204 25655200-8 2015 BP significantly inhibited phosphorylation of Akt and ERK-1/2, JNK and p38 in PC-3 (immunoblotting), and thus adopted a multi-pathway mechanism to exert a more potent anti-proliferative activity against prostate cancer cells than natural and synthetic SERMs. Benzo(a)pyrene 0-2 mitogen-activated protein kinase 1 Homo sapiens 71-74 22126617-7 2011 Furthermore, BaP-induced expression of VEGF mRNA was reduced by the ERK inhibitor PD98059. Benzo(a)pyrene 13-16 mitogen-activated protein kinase 1 Homo sapiens 68-71 25635684-14 2015 Moreover, Bet v 1 was able to induce Erk1/2 and p38 MAPK activation in BP allergics but only a slight p38 activation in normal donors. Benzo(a)pyrene 71-73 mitogen-activated protein kinase 1 Homo sapiens 48-51 21367897-7 2011 The importance of Erk1/2 pathway activation to the BaP-mediated increase in viral titer was determined by Erk pathway inhibition with multiple Erk1/2 pathway inhibitors. Benzo(a)pyrene 51-54 mitogen-activated protein kinase 1 Homo sapiens 18-21 20840854-3 2010 We have evaluated the effects of some highly purified NDL-PCBs and benzo[a]pyrene (BP) on BP-induced Raf, Erk, Mdm2, p53 signaling and on BP-induced apoptosis and cell cycle arrest. Benzo(a)pyrene 83-85 mitogen-activated protein kinase 1 Homo sapiens 106-109