PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21786685-1	2011	Effect of carcinogenic polycyclic aromatic hydrocarbons (PAH) benzo(a)pyrene (BP) and 3-methylcholanthrene (MC) on transcription factor NF-kappaB activation was studied.	Benzo(a)pyrene	78-80	nuclear factor kappa B subunit 1	Homo sapiens	136-145	
30862515-7	2019	Herein we report that 5 mul of 0.1 gm HPE followed by 0.25 muM B[a]P administration enabled down-regulation of IL-2 and TNF-alpha levels in the hippocampus thereby modulating TNFR2 and IL2Rgammac signals via NF-kappaB activation.	Benzo(a)pyrene	63-68	nuclear factor kappa B subunit 1	Homo sapiens	208-217	
29991690-8	2018	Further, we observed a nuclear translocation of NF-kappaB subunits (p50 and p65) after chronic BaP exposure, which was reduced by treatment with siRNA and antioxidants/CYP inhibitors.	Benzo(a)pyrene	95-98	nuclear factor kappa B subunit 1	Homo sapiens	68-71	
32588678-6	2020	Cells exposed to BaP showed prominent changes in the expression of mitochondrial microRNAs (miR-24, miR-34a, miR-150, and miR-155) and their respective gene targets (NF-kappabeta, MYC, and p53).	Benzo(a)pyrene	17-20	nuclear factor kappa B subunit 1	Homo sapiens	166-178	
24431215-8	2014	Both BaP and BPDE inhibited the muscle-specific protein expressions (myogenin and myosin heavy chain) and phosphorylation of Akt (a known modulator in myogenesis), which could be significantly reversed by the inhibitors for aryl hydrocarbon receptor (AhR), estrogen receptor (ER), and nuclear factor (NF)-kappaB.	Benzo(a)pyrene	5-8	nuclear factor kappa B subunit 1	Homo sapiens	285-311	
21786685-6	2011	NF-kappaB activation by BP and MC in hepatoma G27 cells was significantly higher in hepatima G27 cells than in HepG2 cells both in proliferating and resting cells.	Benzo(a)pyrene	24-26	nuclear factor kappa B subunit 1	Homo sapiens	0-9	
10783306-6	2000	In non-tumorigenic MCF-10F cells, in vitro malignant transformation upon treatment with either DMBA or benzo[a]pyrene (B[a]P) resulted in a 4- to 12-fold increase in activity of classical NF-kappaB (p65/p50).	Benzo(a)pyrene	103-117	nuclear factor kappa B subunit 1	Homo sapiens	188-197	
17573710-0	2007	Benzo[a]pyrene-dependent activation of transcription factors NF-kappaB and AP-1 related to tumor promotion in hepatoma cell cultures.	Benzo(a)pyrene	0-14	nuclear factor kappa B subunit 1	Homo sapiens	61-70	
17573710-1	2007	The activation by the carcinogenic polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BP) of transcription factors NF-kappaB and AP-1 in hepatoma 27 and HepG2 cell cultures was studied.	Benzo(a)pyrene	73-87	nuclear factor kappa B subunit 1	Homo sapiens	118-127	
17573710-1	2007	The activation by the carcinogenic polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BP) of transcription factors NF-kappaB and AP-1 in hepatoma 27 and HepG2 cell cultures was studied.	Benzo(a)pyrene	89-91	nuclear factor kappa B subunit 1	Homo sapiens	118-127	
17573710-3	2007	The transcription factor NF-kappaB was activated only in the hepatoma 27 cells by BP treatment but not by its noncarcinogenic isomer benzo[e]pyrene (BeP).	Benzo(a)pyrene	82-84	nuclear factor kappa B subunit 1	Homo sapiens	25-34	
17573710-5	2007	It is concluded that the NF-kappaB activation is caused by nonmetabolized BP molecule and not related to activation of the Ah-receptor.	Benzo(a)pyrene	74-76	nuclear factor kappa B subunit 1	Homo sapiens	25-34	
12807725-4	2003	Benzo[a]pyrene, another potent carcinogen of CS, can also activate NF-kappaB, but by an as yet unknown mechanism.	Benzo(a)pyrene	0-14	nuclear factor kappa B subunit 1	Homo sapiens	67-76	
10915744-3	2000	Eight- and 6-fold increases in nuclear transcription factor kappaB (NF-kappaB), and 5- and 10-fold increases in activated protein (AP-1) transcription factor were observed with 24 hours AFB and BP treatments, respectively, whereas 4-ABP treatment resulted in an approximately 4-fold induction of both NF-kappaB and AP-1.	Benzo(a)pyrene	194-196	nuclear factor kappa B subunit 1	Homo sapiens	60-66	
10915744-3	2000	Eight- and 6-fold increases in nuclear transcription factor kappaB (NF-kappaB), and 5- and 10-fold increases in activated protein (AP-1) transcription factor were observed with 24 hours AFB and BP treatments, respectively, whereas 4-ABP treatment resulted in an approximately 4-fold induction of both NF-kappaB and AP-1.	Benzo(a)pyrene	194-196	nuclear factor kappa B subunit 1	Homo sapiens	68-77	
10915744-3	2000	Eight- and 6-fold increases in nuclear transcription factor kappaB (NF-kappaB), and 5- and 10-fold increases in activated protein (AP-1) transcription factor were observed with 24 hours AFB and BP treatments, respectively, whereas 4-ABP treatment resulted in an approximately 4-fold induction of both NF-kappaB and AP-1.	Benzo(a)pyrene	194-196	nuclear factor kappa B subunit 1	Homo sapiens	301-310	
10783306-6	2000	In non-tumorigenic MCF-10F cells, in vitro malignant transformation upon treatment with either DMBA or benzo[a]pyrene (B[a]P) resulted in a 4- to 12-fold increase in activity of classical NF-kappaB (p65/p50).	Benzo(a)pyrene	103-117	nuclear factor kappa B subunit 1	Homo sapiens	203-206	
34439523-0	2021	Isoorientin Attenuated the Pyroptotic Hepatocyte Damage Induced by Benzo(a)pyrene via ROS/NF-kappaB/NLRP3/Caspase-1 Signaling Pathway.	Benzo(a)pyrene	67-81	nuclear factor kappa B subunit 1	Homo sapiens	90-99	
10575010-0	1999	Benzo[a]pyrene activates the human p53 gene through induction of nuclear factor kappaB activity.	Benzo(a)pyrene	0-14	nuclear factor kappa B subunit 1	Homo sapiens	80-86