PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30982974-9 2019 Moreover, BaP co-exposure with Der f 1 activated AhR signaling with increased expression of AhR and CYP1A1 and promoted airway epithelial ROS generation and TSLP and IL-33, but not IL-25, expression. Benzo(a)pyrene 10-13 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 100-106 29931584-9 2019 An increased expression of CYP1A1 in liver and colon and of CYP1B1 in liver of BaP-treated mice was seen, while RVT inhibited the extent of biotransformation mediated by these enzymes in the respective tissue samples. Benzo(a)pyrene 79-82 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 27-33 28405246-6 2017 However, strangely, increased hepatic BaP-DNA adduct levels have been reported in Cyp1a1 knockout mice. Benzo(a)pyrene 38-41 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 82-88 29366871-0 2018 Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice. Benzo(a)pyrene 113-127 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-19 29366871-0 2018 Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice. Benzo(a)pyrene 113-127 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 21-27 29366871-3 2018 Cytochrome P450 1A1 (CYP1A1) metabolizes BaP, resulting in either detoxication or metabolic activation in a context-dependent manner. Benzo(a)pyrene 41-44 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-19 29366871-3 2018 Cytochrome P450 1A1 (CYP1A1) metabolizes BaP, resulting in either detoxication or metabolic activation in a context-dependent manner. Benzo(a)pyrene 41-44 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 21-27 29366871-5 2018 A Western diet plus BaP induced lipid-droplet accumulation in liver of Cyp1a1(-/-) mice, but not wild-type mice. Benzo(a)pyrene 20-23 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 71-77 29366871-7 2018 Cyp1a1(-/-) mice fed Western diet plus BaP had changes in expression of genes involved in bile acid and lipid metabolism, and showed no increase in Cyp1a2 expression but did exhibit enhanced Cyp1b1 mRNA expression, as well as hepatic inflammation. Benzo(a)pyrene 39-42 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-6 29366871-8 2018 Enhanced BaP metabolic activation, oxidative stress and inflammation may exacerbate metabolic dysfunction in liver of Cyp1a1(-/-) mice. Benzo(a)pyrene 9-12 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 118-124 29366871-9 2018 Thus, Western diet plus BaP induces NAFLD and hepatic inflammation in Cyp1a1(-/-) mice in comparison to wild-type mice, indicating a protective role of CYP1A1 against NAFLD pathogenesis. Benzo(a)pyrene 24-27 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 70-76 29366871-9 2018 Thus, Western diet plus BaP induces NAFLD and hepatic inflammation in Cyp1a1(-/-) mice in comparison to wild-type mice, indicating a protective role of CYP1A1 against NAFLD pathogenesis. Benzo(a)pyrene 24-27 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 152-158 30165701-2 2018 In this study, using Cyp1b1-/-, Cyp1a1/1a2-/-, and Cyp1a1/1a2/1b1-/- mice, we observed that cigarette and environmental toxins, namely benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), induce pancreatic mitochondrial respiratory dysfunction and pancreatitis. Benzo(a)pyrene 135-149 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 32-38 30165701-2 2018 In this study, using Cyp1b1-/-, Cyp1a1/1a2-/-, and Cyp1a1/1a2/1b1-/- mice, we observed that cigarette and environmental toxins, namely benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), induce pancreatic mitochondrial respiratory dysfunction and pancreatitis. Benzo(a)pyrene 135-149 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 51-57 28007926-4 2017 BaP-induced Cyp1a1 and Cyp1b1 mRNA levels were higher 4 hours after dosing at noon than at 4 hours after dosing at midnight, and this corresponded with parallel changes in Per gene expression. Benzo(a)pyrene 0-3 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 12-18 28007926-6 2017 Analysis of CYP1A1 and CYP1B1 gene expression showed the maximum enzyme-induced metabolism response 12 and 20 hours after shock, as determined by ethoxyresorufin-O-deethylase activity, metabolism of BaP, and formation of DNA-BaP adducts. Benzo(a)pyrene 199-202 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 12-18 28007926-6 2017 Analysis of CYP1A1 and CYP1B1 gene expression showed the maximum enzyme-induced metabolism response 12 and 20 hours after shock, as determined by ethoxyresorufin-O-deethylase activity, metabolism of BaP, and formation of DNA-BaP adducts. Benzo(a)pyrene 225-228 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 12-18 28007926-7 2017 The pattern of PER-, BMAL-, and aryl hydrocarbon receptor-induced P450 gene expression and BaP metabolism was similar to BaP-induced Cyp1A1 and Cyp1B1 and molecular clock gene expression in mouse mammary glands. Benzo(a)pyrene 121-124 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 133-139 25995008-8 2016 Our study demonstrates a role for p53 in the metabolism of BaP in vivo, confirming previous in vitro results on a novel role for p53 in CYP1A1-mediated BaP metabolism. Benzo(a)pyrene 59-62 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 136-142 25995008-8 2016 Our study demonstrates a role for p53 in the metabolism of BaP in vivo, confirming previous in vitro results on a novel role for p53 in CYP1A1-mediated BaP metabolism. Benzo(a)pyrene 152-155 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 136-142 25911668-6 2015 Our results showed that Cyp1a1 appears to be important for BaP detoxification in vivo and that the decrease of pulmonary Cyp1a1 activity in LPS/BaP-treated mice results in a decrease of pulmonary BaP detoxification, thereby enhancing BaP genotoxicity (ie, DNA adduct formation) in the lung. Benzo(a)pyrene 59-62 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 24-30 26655880-0 2016 Naringenin ameliorates inflammation and cell proliferation in benzo(a)pyrene induced pulmonary carcinogenesis by modulating CYP1A1, NFkappaB and PCNA expression. Benzo(a)pyrene 62-76 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 124-130 26215100-4 2015 A set of 63 genes was identified (the AhR gene expression biomarker) that was dependent on AhR for regulation after exposure to TCDD or benzo[a]pyrene and includes the known AhR targets Cyp1a1 and Cyp1b1. Benzo(a)pyrene 136-150 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 186-192 25911668-0 2015 Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene. Benzo(a)pyrene 121-135 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 34-40 25911668-5 2015 Pulmonary Cyp1a1 enzyme activity was decreased in LPS/BaP-treated mice relative to BaP-treated mice suggesting that pulmonary inflammation impacted on BaP-induced Cyp1a1 activity in the lung. Benzo(a)pyrene 54-57 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 10-16 25911668-5 2015 Pulmonary Cyp1a1 enzyme activity was decreased in LPS/BaP-treated mice relative to BaP-treated mice suggesting that pulmonary inflammation impacted on BaP-induced Cyp1a1 activity in the lung. Benzo(a)pyrene 54-57 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 163-169 25911668-6 2015 Our results showed that Cyp1a1 appears to be important for BaP detoxification in vivo and that the decrease of pulmonary Cyp1a1 activity in LPS/BaP-treated mice results in a decrease of pulmonary BaP detoxification, thereby enhancing BaP genotoxicity (ie, DNA adduct formation) in the lung. Benzo(a)pyrene 144-147 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 24-30 25911668-6 2015 Our results showed that Cyp1a1 appears to be important for BaP detoxification in vivo and that the decrease of pulmonary Cyp1a1 activity in LPS/BaP-treated mice results in a decrease of pulmonary BaP detoxification, thereby enhancing BaP genotoxicity (ie, DNA adduct formation) in the lung. Benzo(a)pyrene 144-147 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 121-127 25911668-6 2015 Our results showed that Cyp1a1 appears to be important for BaP detoxification in vivo and that the decrease of pulmonary Cyp1a1 activity in LPS/BaP-treated mice results in a decrease of pulmonary BaP detoxification, thereby enhancing BaP genotoxicity (ie, DNA adduct formation) in the lung. Benzo(a)pyrene 144-147 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 24-30 25911668-6 2015 Our results showed that Cyp1a1 appears to be important for BaP detoxification in vivo and that the decrease of pulmonary Cyp1a1 activity in LPS/BaP-treated mice results in a decrease of pulmonary BaP detoxification, thereby enhancing BaP genotoxicity (ie, DNA adduct formation) in the lung. Benzo(a)pyrene 144-147 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 121-127 25911668-7 2015 Because less BaP was detoxified by Cyp1a1 in the lungs of LPS/BaP-treated mice, more BaP circulated via the blood to extrapulmonary tissues relative to mice treated with BaP only. Benzo(a)pyrene 13-16 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 35-41 25911668-7 2015 Because less BaP was detoxified by Cyp1a1 in the lungs of LPS/BaP-treated mice, more BaP circulated via the blood to extrapulmonary tissues relative to mice treated with BaP only. Benzo(a)pyrene 62-65 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 35-41 25911668-7 2015 Because less BaP was detoxified by Cyp1a1 in the lungs of LPS/BaP-treated mice, more BaP circulated via the blood to extrapulmonary tissues relative to mice treated with BaP only. Benzo(a)pyrene 62-65 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 35-41 25911668-7 2015 Because less BaP was detoxified by Cyp1a1 in the lungs of LPS/BaP-treated mice, more BaP circulated via the blood to extrapulmonary tissues relative to mice treated with BaP only. Benzo(a)pyrene 62-65 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 35-41 25911668-10 2015 Cyp1a1 appears to be involved in both BaP bioactivation and detoxification although the contribution of other enzymes to BaP-DNA adduct formation in lung and liver under inflammatory conditions remains to be explored. Benzo(a)pyrene 38-41 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-6 24530354-7 2014 At a ratio of POR:CYP1A1 of 0.05:1, addition of cytochrome b5 increased CYP1A1-mediated BaP oxidation to most of its metabolites indicating that cytochrome b5 participates in the electron transfer from NADPH to CYP1A1 required for enzyme activity of this CYP. Benzo(a)pyrene 88-91 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 18-24 25230394-2 2015 At 2 muM, BaP induced Cyp1a1 expression in MEFs to a much greater extent than in ES cells and formed 45 times more adducts. Benzo(a)pyrene 10-13 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 22-28 24530354-3 2014 In microsomes from BaP-pretreated mice, in which Cyp1a1 was induced, higher levels of BaP metabolites were formed, mainly of BaP-7,8-dihydrodiol. Benzo(a)pyrene 19-22 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 49-55 24530354-3 2014 In microsomes from BaP-pretreated mice, in which Cyp1a1 was induced, higher levels of BaP metabolites were formed, mainly of BaP-7,8-dihydrodiol. Benzo(a)pyrene 86-89 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 49-55 24497629-6 2014 Administration of benzo[a]pyrene or 2,3,7,8-tetrachlorodibenzodioxin induced similar mitochondrial functional abnormalities and oxidative stress in the lungs of wild-type mice and Cyp1a1/1a2-null mice, but the effects were markedly blunted in Cyp1b1-null mice. Benzo(a)pyrene 18-32 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 180-186 25297811-5 2014 Gene ontology analysis also revealed that BaP-induced bioactivities were tissue specific; eight genes (Tubb5, Fos, Cdh1, Cyp1a1, Apc, Myc, Ctnnb1 and Cav) showed significant expression difference between three target and three non-target organs. Benzo(a)pyrene 42-45 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 121-127 24530354-7 2014 At a ratio of POR:CYP1A1 of 0.05:1, addition of cytochrome b5 increased CYP1A1-mediated BaP oxidation to most of its metabolites indicating that cytochrome b5 participates in the electron transfer from NADPH to CYP1A1 required for enzyme activity of this CYP. Benzo(a)pyrene 88-91 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 72-78 24530354-7 2014 At a ratio of POR:CYP1A1 of 0.05:1, addition of cytochrome b5 increased CYP1A1-mediated BaP oxidation to most of its metabolites indicating that cytochrome b5 participates in the electron transfer from NADPH to CYP1A1 required for enzyme activity of this CYP. Benzo(a)pyrene 88-91 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 72-78 24530354-9 2014 Our results suggest that in livers of HRN mice Cyp1a1, cytochrome b5 and mEH can effectively activate BaP to DNA binding species, even in the presence of very low amounts of POR. Benzo(a)pyrene 102-105 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 47-53 24394547-0 2014 Protective role of cytochrome P450 1A1 (CYP1A1) against benzo[a]pyrene-induced toxicity in mouse aorta. Benzo(a)pyrene 56-70 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 19-38 24394547-8 2014 BaP treatment increased Vegfa mRNA levels in mouse embryonic fibroblasts from Cyp1a1-/- mice but not from wild-type mice. Benzo(a)pyrene 0-3 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 78-84 24394547-9 2014 BaP-induced DNA adduct formation was increased in the aorta of Cyp1a1-/- mice, but not wild-type or Apoe-/- mice, and the atherogenic diet decreased BaP-induced DNA adducts in Cyp1a1-/- mice compared with mice on a control diet. Benzo(a)pyrene 0-3 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 63-69 24394547-9 2014 BaP-induced DNA adduct formation was increased in the aorta of Cyp1a1-/- mice, but not wild-type or Apoe-/- mice, and the atherogenic diet decreased BaP-induced DNA adducts in Cyp1a1-/- mice compared with mice on a control diet. Benzo(a)pyrene 0-3 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 176-182 24394547-9 2014 BaP-induced DNA adduct formation was increased in the aorta of Cyp1a1-/- mice, but not wild-type or Apoe-/- mice, and the atherogenic diet decreased BaP-induced DNA adducts in Cyp1a1-/- mice compared with mice on a control diet. Benzo(a)pyrene 149-152 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 176-182 24394547-10 2014 These data suggest that ROS production contributes to BaP-exacerbated atherosclerosis and that CYP1A1 plays a protective role against oral BaP toxicity in aorta. Benzo(a)pyrene 139-142 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 95-101 24394547-0 2014 Protective role of cytochrome P450 1A1 (CYP1A1) against benzo[a]pyrene-induced toxicity in mouse aorta. Benzo(a)pyrene 56-70 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 40-46 24394547-2 2014 Cytochrome P450 1A1 (CYP1A1) plays a role in both metabolic activation and detoxication of BaP in a context-dependent manner. Benzo(a)pyrene 91-94 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-19 24394547-2 2014 Cytochrome P450 1A1 (CYP1A1) plays a role in both metabolic activation and detoxication of BaP in a context-dependent manner. Benzo(a)pyrene 91-94 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 21-27 24394547-7 2014 The atherogenic diet plus BaP effectively elevated plasma ROS levels and expression of atherosclerosis-related genes, specifically Vegfa, in Cyp1a1-/- mice compared with wild-type mice. Benzo(a)pyrene 26-29 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 141-147 23047765-0 2013 Oral benzo[a]pyrene in Cyp1a1/1b1(-/-) double-knockout mice: Microarray analysis during squamous cell carcinoma formation in preputial gland duct. Benzo(a)pyrene 5-19 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 23-29 23761301-5 2013 Ten-fold lower oral BaP doses result in adenocarcinoma of the proximal small intestine (PSI) in Cyp1a1(-/-) mice; Cyp1a1/1b1(-/-) double-knockout mice show no PSI cancer but develop squamous cell carcinoma of the preputial gland duct (PGD). Benzo(a)pyrene 20-23 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 96-102 22619112-5 2012 Initial studies characterizing the metabolic capacity of proliferating lacZ primary hepatocytes indicated that these cells retained at least some activities important for xenobiotic metabolism: cytochrome P450 1A1 enzyme activities were markedly increased in the hepatocytes after exposure to benzo[a]pyrene, and also UDP-glucuronosyl transferase and glutathione-S-transferase activities, both Phase II enzymes, were detected. Benzo(a)pyrene 293-307 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 194-213 22486318-7 2012 Similarly, benzo(a)pyrene (BaP) at 10 nM reduced AhR and increased CYP1A1 and 1B1 mRNAs. Benzo(a)pyrene 11-25 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 67-81 22486318-7 2012 Similarly, benzo(a)pyrene (BaP) at 10 nM reduced AhR and increased CYP1A1 and 1B1 mRNAs. Benzo(a)pyrene 27-30 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 67-81 22442665-4 2012 Here we report that intestinal CYP1A1 is silenced in TLR2-deficient mice, even when under exposure to the carcinogenic PAH benzo[a]pyrene (BaP). Benzo(a)pyrene 123-137 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 31-37 22442665-4 2012 Here we report that intestinal CYP1A1 is silenced in TLR2-deficient mice, even when under exposure to the carcinogenic PAH benzo[a]pyrene (BaP). Benzo(a)pyrene 139-142 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 31-37 21733121-5 2011 BaP treatment caused a significant increase in the levels of MDA and IL-6 with significantly increased activity of CYP1A1, creatine kinase and aspartate aminotransferase (AST) and decreased activity of glutathione-S-transferase in the cervix and liver. Benzo(a)pyrene 0-3 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 115-121 21872649-2 2011 We show that 1-NP and the referent PAH benzo(a)pyrene (BP) induce apoptosis and a lipid accumulation dependent on cytochrome P450 1A1-metabolites in mouse hepatoma cells, whereas 1-amino-pyrene had no effect. Benzo(a)pyrene 39-53 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 114-133 21872649-2 2011 We show that 1-NP and the referent PAH benzo(a)pyrene (BP) induce apoptosis and a lipid accumulation dependent on cytochrome P450 1A1-metabolites in mouse hepatoma cells, whereas 1-amino-pyrene had no effect. Benzo(a)pyrene 55-57 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 114-133 21130824-9 2011 Together, these results suggest that the protective effect of GJ against the genotoxicity of BaP may be related to the inhibition of Cyp1a1 enzyme activity. Benzo(a)pyrene 93-96 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 133-139 20127859-3 2010 Following high dosage of oral BaP (125 mg/kg/day), ablation of the mouse Cyp1a1 gene causes immunosuppression and death within ~28 days, whereas Cyp1(+/+) wild-type mice remain healthy for >12 months on this regimen. Benzo(a)pyrene 30-33 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 73-79 19666105-4 2009 After BaP exposure, the amount of AhR binding to the cytochrome P450 (CYP) 1A1 promoter was significantly greater, and the concentrations of BaP reactive intermediates were significantly less in MAECs overexpressing Cu/Zn-SOD and/or catalase than in wild-type cells. Benzo(a)pyrene 6-9 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 53-78 20400470-6 2010 In addition, we observed greater differences in the rates of clearance of oral BaP, between WT and IE-Cpr-null mice, in mice pretreated with beta-naphthoflavone, to induce CYP1A1 expression, than in untreated mice. Benzo(a)pyrene 79-82 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 172-178 20400470-7 2010 The onset of induction (at 2 h after dosing) of CYP1A1 protein expression by oral BaP administration was earlier in the SI than in extra-gut organs analyzed; for liver, lung, and kidney, induction was not observed until 4 h after dosing. Benzo(a)pyrene 82-85 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 48-54 20400470-9 2010 Taken together, these findings strongly support the concept that small-intestinal CYP1A1 induction is a critical factor in protection against systemic exposure to oral BaP. Benzo(a)pyrene 168-171 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 82-88 20371670-0 2010 Organ-specific roles of CYP1A1 during detoxication of dietary benzo[a]pyrene. Benzo(a)pyrene 62-76 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 24-30 20371670-4 2010 This lab has previously shown that Cyp1a1(-/-) global knockout mice treated by oral administration of BaP die at 28 to 32 days with immunosuppression, whereas wild-type mice remain healthy for 1 year on high BaP doses (125 mg/kg/day). Benzo(a)pyrene 102-105 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 35-41 20371670-5 2010 Thus, for oral BaP, CYP1A1 is more important in detoxication than in metabolic activation. Benzo(a)pyrene 15-18 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 20-26 20371670-6 2010 After several days of oral BaP, we found surprisingly low CYP1A1 levels in liver, compared with that in small intestine; we postulated that this finding might reflect efficient detoxication of oral BaP in proximal small intestine such that significant amounts of the inducer BaP no longer reach the liver. Benzo(a)pyrene 27-30 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 58-64 20371670-10 2010 We conclude that small intestine CYP1A1, and not liver CYP1A1, is critically important in oral BaP detoxication. Benzo(a)pyrene 95-98 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 33-39 19666105-5 2009 In addition, the BaP-induced CYP1A1 and 1B1 protein levels and BaP-elevated glutathione S-transferase (GST) activity were significantly higher in these transgenic cells, in parallel with elevated GSTp1, CYP1A1, and CYP1B1 mRNA levels, compared to wild-type MAECs. Benzo(a)pyrene 17-20 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 29-43 19666105-5 2009 In addition, the BaP-induced CYP1A1 and 1B1 protein levels and BaP-elevated glutathione S-transferase (GST) activity were significantly higher in these transgenic cells, in parallel with elevated GSTp1, CYP1A1, and CYP1B1 mRNA levels, compared to wild-type MAECs. Benzo(a)pyrene 17-20 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 29-35 18694800-3 2008 The aim of the present study was further examination of the effect of these compounds on the expression and activities of CYP1A1/1A2, CYP1B1, CYP2B, and phase 2 enzymes in female BALB/C mouse epidermis treated with an initiating dose of B[a]P or DMBA. Benzo(a)pyrene 237-242 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 122-128 18022386-0 2008 Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient mice. Benzo(a)pyrene 67-81 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 16-35 18372398-3 2008 Oral benzo[a]pyrene (BaP) daily for 18 days in the Cyp1a1/1a2(-/-) produced the same degree of marked immunosuppression as seen in the Cyp1a1(-/-) mouse; we believe this reflects the absence of intestinal CYP1A1. Benzo(a)pyrene 5-19 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 51-57 18372398-3 2008 Oral benzo[a]pyrene (BaP) daily for 18 days in the Cyp1a1/1a2(-/-) produced the same degree of marked immunosuppression as seen in the Cyp1a1(-/-) mouse; we believe this reflects the absence of intestinal CYP1A1. Benzo(a)pyrene 5-19 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 135-141 18372398-3 2008 Oral benzo[a]pyrene (BaP) daily for 18 days in the Cyp1a1/1a2(-/-) produced the same degree of marked immunosuppression as seen in the Cyp1a1(-/-) mouse; we believe this reflects the absence of intestinal CYP1A1. Benzo(a)pyrene 5-19 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 205-211 18372398-3 2008 Oral benzo[a]pyrene (BaP) daily for 18 days in the Cyp1a1/1a2(-/-) produced the same degree of marked immunosuppression as seen in the Cyp1a1(-/-) mouse; we believe this reflects the absence of intestinal CYP1A1. Benzo(a)pyrene 21-24 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 51-57 18372398-3 2008 Oral benzo[a]pyrene (BaP) daily for 18 days in the Cyp1a1/1a2(-/-) produced the same degree of marked immunosuppression as seen in the Cyp1a1(-/-) mouse; we believe this reflects the absence of intestinal CYP1A1. Benzo(a)pyrene 21-24 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 135-141 18372398-3 2008 Oral benzo[a]pyrene (BaP) daily for 18 days in the Cyp1a1/1a2(-/-) produced the same degree of marked immunosuppression as seen in the Cyp1a1(-/-) mouse; we believe this reflects the absence of intestinal CYP1A1. Benzo(a)pyrene 21-24 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 205-211 18372398-4 2008 Oral BaP-treated Cyp1a1/1a2/1b1(-/-) mice showed the same "rescued" response as that seen in the Cyp1a1/1b1(-/-) mouse; we believe this reflects the absence of CYP1B1 in immune tissues. Benzo(a)pyrene 5-8 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 17-23 18372398-4 2008 Oral BaP-treated Cyp1a1/1a2/1b1(-/-) mice showed the same "rescued" response as that seen in the Cyp1a1/1b1(-/-) mouse; we believe this reflects the absence of CYP1B1 in immune tissues. Benzo(a)pyrene 5-8 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 97-103 17997381-1 2008 The CYP1A1, CYP1A2, and CYP1B1 enzymes are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); metabolism of BaP by these enzymes leads to electrophilic intermediates and genotoxicity. Benzo(a)pyrene 56-70 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 4-10 15279838-5 2004 Benzo[a]pyrene was also activated efficiently by CYP1A1 and weakly by CYP1A2, CYP2C9, CYP2C19, and CYP3A4 expressed in TA1538. Benzo(a)pyrene 0-14 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 49-55 17433523-0 2007 Abundance of aryl hydrocarbon receptor potentiates benzo[a]pyrene-induced apoptosis in Hepa1c1c7 cells via CYP1A1 activation. Benzo(a)pyrene 51-65 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 107-113 16377763-0 2006 Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate. Benzo(a)pyrene 5-19 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 50-56 16377763-1 2006 CYP1A1 and CYP1B1 metabolically activate many polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene, to reactive intermediates associated with toxicity, mutagenesis, and carcinogenesis. Benzo(a)pyrene 97-111 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-6 16377763-4 2006 After administration of oral benzo[a]pyrene (125 mg/kg/day) for 18 days, Cyp1a1-/- mice showed marked wasting, immunosuppression, and bone marrow hypocellularity, whereas the other five genotypes did not. Benzo(a)pyrene 29-43 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 73-79 16377763-5 2006 After 5 days of feeding, steady-state blood levels of benzo[a]pyrene were approximately 25 and approximately 75 times higher in Cyp1a1-/- and Cyp1a1/1b1-/- mice, respectively, than in wild-type mice. Benzo(a)pyrene 54-68 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 128-134 16377763-5 2006 After 5 days of feeding, steady-state blood levels of benzo[a]pyrene were approximately 25 and approximately 75 times higher in Cyp1a1-/- and Cyp1a1/1b1-/- mice, respectively, than in wild-type mice. Benzo(a)pyrene 54-68 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 142-148 16377763-6 2006 Benzo[a]pyrene-DNA adduct levels were highest in liver, spleen, and marrow of Cyp1a1-/- and Cyp1a1/1b1-/- mice. Benzo(a)pyrene 0-14 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 78-84 16377763-6 2006 Benzo[a]pyrene-DNA adduct levels were highest in liver, spleen, and marrow of Cyp1a1-/- and Cyp1a1/1b1-/- mice. Benzo(a)pyrene 0-14 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 92-98 16377763-8 2006 Thus, a balance between tissue-specific expression of the CYP1A1 and CYP1B1 enzymes governs sensitivity of benzo[a]pyrene toxicity and, possibly, carcinogenicity. Benzo(a)pyrene 107-121 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 58-64 15667830-0 2005 Induction of CYP1A1 and CYP1B1 in liver and lung by benzo(a)pyrene and 7,12-d imethylbenz(a)anthracene do not affect distribution of polycyclic hydrocarbons to target tissue: role of AhR and CYP1B1 in bone marrow cytotoxicity. Benzo(a)pyrene 52-66 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 13-19 15667830-5 2005 BP strongly induces CYP1A1 around the hepatic vein whereas DMBA produces a weaker diffuse response, paralleling differences in CYP1A1 protein. Benzo(a)pyrene 0-2 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 20-26 15667830-7 2005 BP and DMBA broadly and equally induce CYP1A1 in the lung, while CYP1B1 is induced in bronchial blood vessels. Benzo(a)pyrene 0-2 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 39-45 15102951-1 2004 The cytochrome P450 (CYP1A1) enzyme metabolically activates many polycyclic aromatic hydrocarbons, including benzo[a]pyrene (BaP), to DNA- and protein-binding intermediates that are associated with toxicity, mutagenesis, and carcinogenesis. Benzo(a)pyrene 109-123 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 21-27 14613719-0 2003 Bone marrow cytotoxicity of benzo[a]pyrene is dependent on CYP1B1 but is diminished by Ah receptor-mediated induction of CYP1A1 in liver. Benzo(a)pyrene 28-42 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 121-127 14976333-12 2004 At the same time, Cag caused a marked inhibition of DMBA-induced aryl hydrocarbon hydroxylase (AHH) activity, an enzyme responsible for the metabolism of PAHs like BP, both in vivo and in vitro. Benzo(a)pyrene 164-166 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 65-93 14976333-12 2004 At the same time, Cag caused a marked inhibition of DMBA-induced aryl hydrocarbon hydroxylase (AHH) activity, an enzyme responsible for the metabolism of PAHs like BP, both in vivo and in vitro. Benzo(a)pyrene 164-166 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 95-98 14613719-7 2003 In wild-type mice, BP treatment leads to a fivefold greater induction of hepatic CYP1A1 than that of DMBA treatment. Benzo(a)pyrene 19-21 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 81-87 8967965-1 1996 Rare benzo[a]pyrene-resistant clones were previously isolated from the mouse hepatoma cell line, Hepa-1 (Hepa1c1c7), and shown to be deficient in induction of CYP1A1 mRNA by ligands for the aryl hydrocarbon receptor (AHR). Benzo(a)pyrene 5-19 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 159-165 12649394-8 2003 BP treatment of SMCs resulted in induction of aryl hydrocarbon hydroxylase (AHH) activity and CYP1B1, but not CYP1A1, apoprotein. Benzo(a)pyrene 0-2 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 46-74 12649394-8 2003 BP treatment of SMCs resulted in induction of aryl hydrocarbon hydroxylase (AHH) activity and CYP1B1, but not CYP1A1, apoprotein. Benzo(a)pyrene 0-2 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 76-79 12649394-9 2003 EP also blocked AHH induction by BP. Benzo(a)pyrene 33-35 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 16-19 12455047-3 2003 The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC). Benzo(a)pyrene 121-135 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 84-90 12455047-3 2003 The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC). Benzo(a)pyrene 137-139 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 84-90 11577022-4 2001 Although Cyp1a1 was inducible in Ahr(+/+) by 3 micromol/L benzo(a)pyrene, a known hydrocarbon inducer, the protein was uninducible. Benzo(a)pyrene 58-72 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 9-15 9217241-0 1997 Effect of the route of benzo[a]pyrene administration on sister chromatid exchange and DNA binding in bone marrow of mice differing with respect to cytochrome P450 1A1 induction. Benzo(a)pyrene 23-37 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 147-166 11741297-0 2001 Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels. Benzo(a)pyrene 0-14 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 59-65 11741297-1 2001 Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products. Benzo(a)pyrene 136-150 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 33-52 11741297-1 2001 Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products. Benzo(a)pyrene 136-150 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 54-60 11171528-7 2001 In contrast, administration of BaP up-regulated only Cyp1a1 and Cyp1a2 genes and produced no significant increases in any of the stress response genes or any of the DNA repair genes present on the array. Benzo(a)pyrene 31-34 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 53-59 10503953-5 1999 Cotreatment with alpha-naphthoflavone, a CYP1A1 inhibitor, abolished DNA adduct formation by B[a]P in CL3 cells. Benzo(a)pyrene 93-98 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 41-47 1973007-4 1990 The inducibility of AHH by BaP treatment was depressed by 30-70% in MCA and 7SA cells over a 36-hr time course. Benzo(a)pyrene 27-30 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 20-23 8246314-0 1993 High susceptibility to aflatoxin B1 and benzo[a]pyrene of BALB3T3 A31-1-1 cells expressing monkey CYP1A1. Benzo(a)pyrene 40-54 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 98-104 8246314-1 1993 The monkey CYP1A1 has been expressed in BALB 3T3 A31-1-1 cells and the expressed proteins were assayed for their capacity to activate aflatoxin B1 (AFB1) and benzo[a]pyrene (B[a]P). Benzo(a)pyrene 158-172 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 11-17 8395783-4 1993 The original observations about genetic differences in CYP1A1 (cytochrome P1-450) induction by TCDD or benzo[a]pyrene in the mouse have led to an appreciation for a similar polymorphism in the human and the recent cloning of the murine Ah receptor (Ahr) and human Ah receptor nuclear translocator (ARNT) genes. Benzo(a)pyrene 103-117 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 55-61 1846026-6 1991 We found that at both doses of BP, the number of SCEs and BP-DNA adducts in bone marrow and in spleen cells was significantly higher in aryl hydrocarbon hydroxylase (AHH)-non-inducible (DBA/2) mice than in AHH-inducible (C57BL/6) mice. Benzo(a)pyrene 31-33 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 136-164 1846026-6 1991 We found that at both doses of BP, the number of SCEs and BP-DNA adducts in bone marrow and in spleen cells was significantly higher in aryl hydrocarbon hydroxylase (AHH)-non-inducible (DBA/2) mice than in AHH-inducible (C57BL/6) mice. Benzo(a)pyrene 31-33 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 166-169 1846026-6 1991 We found that at both doses of BP, the number of SCEs and BP-DNA adducts in bone marrow and in spleen cells was significantly higher in aryl hydrocarbon hydroxylase (AHH)-non-inducible (DBA/2) mice than in AHH-inducible (C57BL/6) mice. Benzo(a)pyrene 31-33 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 206-209 1692256-3 1990 The AHH activity of cells treated with either benz(a)anthracene, benzo(a)pyrene, 3-methylcholanthrene, or TCDD continuously or 24 h before harvesting was measured during observation periods for up to 5 days. Benzo(a)pyrene 65-79 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 4-7 1692256-4 1990 Slight induction of AHH activity by benz(a)anthracene, benzo(a)pyrene, and 3-methylcholanthrene was observed in hepatocytes from the CBA and C3H/He strains during the first half of the observation period, followed by a steep increase thereafter. Benzo(a)pyrene 55-69 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 20-23 8902877-4 1996 Oral administration of TMK688 (30 mg/kg) almost completely suppressed Cyp1a1 mRNA levels in mouse epidermis induced by a topical application of MC (40 mg/kg) or benzo[a]pyrene (200 nmol) to mouse skin. Benzo(a)pyrene 161-175 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 70-76 20693087-6 1994 It is suggested that vitamin C is directly bound to the substrate BP, to cytochrome P-450 itself or to the substrate-enzyme complex, thus lowering the rate of AHH reaction, and that the mechanisms of inhibition of AHH and suppression of mutagenicity by vitamin C are different from those of PCB metabolites. Benzo(a)pyrene 66-68 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 159-162 12369593-4 1994 Nevertheless, DMBA induces a specific isozyme of cytochrome P-450 1A1 since, for an equal dose administered to C57BL/6 mice (200 mg/kg body weight), the DMBA-hydroxylase activity was 1.72-fold increased by DMBA while it remained unchanged after BP treatment. Benzo(a)pyrene 245-247 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 49-69 1846026-10 1991 The present data confirm the influence of inducibility of AHH in the intestine on the genotoxicity of BP to distal tissues after oral exposure to BP. Benzo(a)pyrene 102-104 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 58-61 1846026-10 1991 The present data confirm the influence of inducibility of AHH in the intestine on the genotoxicity of BP to distal tissues after oral exposure to BP. Benzo(a)pyrene 146-148 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 58-61 34472326-6 2021 Using samples displaying Cyp1a1 induction, we observed significantly higher metabolic affinity for BaP metabolism (Km reduced 3-fold), 3-fold higher intrinsic clearance, but no changes to the Vmax. Benzo(a)pyrene 99-102 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 25-31 33800341-4 2021 Repeated oral administration of B[a]P led to, at the doses of 20 and 200 mg/kg/day, significant overexpression of Cyp1a1/Cyp1b1 in 2 out of the 3 brain regions considered, thereby suggesting the ability of the brain to metabolize B[a]P itself. Benzo(a)pyrene 32-37 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 114-120 33800341-4 2021 Repeated oral administration of B[a]P led to, at the doses of 20 and 200 mg/kg/day, significant overexpression of Cyp1a1/Cyp1b1 in 2 out of the 3 brain regions considered, thereby suggesting the ability of the brain to metabolize B[a]P itself. Benzo(a)pyrene 230-235 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 114-120 2505924-0 1989 Induction of aryl hydrocarbon hydroxylase and DNA adduct formation in parental and carcinogen transformed C3H/10T1/2 clone 8 cells by benzo[a]pyrene. Benzo(a)pyrene 134-148 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 13-41 34290363-5 2021 In particular, whether benzo(a)pyrene (B(a)P), a carcinogen of tobacco smoke, induces expression of the AhR target gene, Cyp1a1, in mandibular condyles. Benzo(a)pyrene 23-37 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 121-127 34290363-5 2021 In particular, whether benzo(a)pyrene (B(a)P), a carcinogen of tobacco smoke, induces expression of the AhR target gene, Cyp1a1, in mandibular condyles. Benzo(a)pyrene 39-44 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 121-127 35065163-10 2022 Significant overexpression of AHR, GSTM1, CYP1A1, PTGS2, PLA2G4A, and NOS3 genes was noted in cells treated with EPA and BaP. Benzo(a)pyrene 121-124 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 42-48 2505924-2 1989 AHH activity in 10T1/2 cells was measured before and after culturing in the presence of benzo[a]pyrene (B[a]P), and compared to the AHH activity found in carcinogen-transformed 10T1/2 cell lines treated similarly. Benzo(a)pyrene 88-102 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-3 2505924-2 1989 AHH activity in 10T1/2 cells was measured before and after culturing in the presence of benzo[a]pyrene (B[a]P), and compared to the AHH activity found in carcinogen-transformed 10T1/2 cell lines treated similarly. Benzo(a)pyrene 104-109 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-3 2576817-1 1989 Certain strains of mice vary in their enzyme inducibility by polycyclic hydrocarbons, i.e., the strain C57 shows high and the strain DBA shows low inducibility of aryl hydrocarbon hydroxylase (AHH) by benzo[a]pyrene (BaP). Benzo(a)pyrene 201-215 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 163-191 2492425-5 1989 The in vivo and in vitro effects of schistosomicidal drugs on the activity of AHH were investigated using benzo(a)pyrene (BP) as substrate. Benzo(a)pyrene 106-120 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 78-81 2492425-5 1989 The in vivo and in vitro effects of schistosomicidal drugs on the activity of AHH were investigated using benzo(a)pyrene (BP) as substrate. Benzo(a)pyrene 122-124 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 78-81 2576817-1 1989 Certain strains of mice vary in their enzyme inducibility by polycyclic hydrocarbons, i.e., the strain C57 shows high and the strain DBA shows low inducibility of aryl hydrocarbon hydroxylase (AHH) by benzo[a]pyrene (BaP). Benzo(a)pyrene 201-215 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 193-196 2576817-1 1989 Certain strains of mice vary in their enzyme inducibility by polycyclic hydrocarbons, i.e., the strain C57 shows high and the strain DBA shows low inducibility of aryl hydrocarbon hydroxylase (AHH) by benzo[a]pyrene (BaP). Benzo(a)pyrene 217-220 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 163-191 2576817-1 1989 Certain strains of mice vary in their enzyme inducibility by polycyclic hydrocarbons, i.e., the strain C57 shows high and the strain DBA shows low inducibility of aryl hydrocarbon hydroxylase (AHH) by benzo[a]pyrene (BaP). Benzo(a)pyrene 217-220 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 193-196 2576817-7 1989 The high BaP-induced AHH activity found in heterozygous embryos of DBA dams is in agreement with the dominant mode of inheritance for high AHH inducibility. Benzo(a)pyrene 9-12 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 21-24 2576817-7 1989 The high BaP-induced AHH activity found in heterozygous embryos of DBA dams is in agreement with the dominant mode of inheritance for high AHH inducibility. Benzo(a)pyrene 9-12 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 139-142 2576817-10 1989 The AHH inducibility by BaP did not correlate quantitatively with the induced aberration rates. Benzo(a)pyrene 24-27 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 4-7 3096852-9 1986 Diet-induced changes in monooxygenase activities were found to be the best indicators of changes in microsome-mediated BP mutagenesis and AFB1 mutagenesis and binding to DNA in vitro, with a direct correlation between high AHH and/or ECD activities and the levels of mutagenic response to BP or AFB1 in the Ames assay and of DNA binding of AFB1. Benzo(a)pyrene 289-291 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 223-226 3103261-16 1987 Lung AHH and 7-ethoxyresorufin O-deethylase activities were increased 4.3- and 3.1-fold, respectively, and cytochrome P-450 content, benzphetamine N-demethylase and nitroreductase activities were decreased 1.4-, 1.2- and 1.3-fold, respectively, after BaP administration. Benzo(a)pyrene 251-254 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 5-8 6322386-7 1984 On the contrary we have observed an inhibition of B[a]P metabolism by 6a-chrysene, which can reach 80% of the aryl hydrocarbon hydroxylase (AHH) activity when 6a-chrysene remains constant in the cells. Benzo(a)pyrene 50-55 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 110-138 3998503-7 1985 The reduction in AHH activity paralleled the levels of enzyme-mediated binding of radiolabeled BP metabolites and of BPDE-I to epidermal DNA. Benzo(a)pyrene 95-97 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 17-20 6318770-8 1983 Also in the responsive strains, induction of AFB1-4-hydroxylase activity was strongly associated with (a) the depression of the mutagenic activation of AFB1, and (b) with the induction of both AHH and the mutagenic activation of benzo[a]pyrene. Benzo(a)pyrene 229-243 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 193-196 6623311-1 1983 Fifty-four benzo[a]pyrene (BP)-resistant, aryl hydrocarbon hydroxylase (AHH)-deficient mutants were found to be recessive, while five were dominant. Benzo(a)pyrene 11-25 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 72-75 7120116-3 1982 In vitro treatment of the cells or in vivo application to the skin of animals with the polycyclic aromatic hydrocarbons benz(a)anthracene (BA) or benzo(a)pyrene resulted in significant induction of AHH and 7-ED activities. Benzo(a)pyrene 146-160 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 198-201 6298084-2 1983 We examined the relationship between the ability of I-3-C to alter the activity of hepatic aryl hydrocarbon hydroxylase (AHH), and its ability to inhibit the covalent binding of benzo[a]pyrene (BaP) metabolites to DNA and protein. Benzo(a)pyrene 178-192 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 121-124 6298084-3 1983 Using an in vitro system and a hepatic postmitochondrial fraction from mice that had been treated by gavage with I-3-C, we found that up to 90% of the covalent binding of BaP metabolites to macromolecules was eliminated, while AHH activity was unchanged. Benzo(a)pyrene 171-174 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 227-230 118380-8 1979 This lack of correlation between increased AHH activity and increased metabolism of BP to mutagen in liver is in marked contrast to correlations seen in mice. Benzo(a)pyrene 84-86 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 43-46 7438292-12 1980 As with basal AHH, the Km-value for BP was less in log phase (0.2-0.4 microM BP) than in confluent cells (0.64-1.05 microM BP). Benzo(a)pyrene 36-38 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 14-17 7438292-12 1980 As with basal AHH, the Km-value for BP was less in log phase (0.2-0.4 microM BP) than in confluent cells (0.64-1.05 microM BP). Benzo(a)pyrene 77-79 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 14-17 7438292-12 1980 As with basal AHH, the Km-value for BP was less in log phase (0.2-0.4 microM BP) than in confluent cells (0.64-1.05 microM BP). Benzo(a)pyrene 77-79 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 14-17 7428109-2 1980 BP metabolite formation was monitored by high pressure liquid chromatography (HPLC) and by following aryl hydrocarbon hydroxylase (AHH) activity. Benzo(a)pyrene 0-2 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 101-129 7428109-2 1980 BP metabolite formation was monitored by high pressure liquid chromatography (HPLC) and by following aryl hydrocarbon hydroxylase (AHH) activity. Benzo(a)pyrene 0-2 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 131-134 7428109-6 1980 The induction of AHH by MC in these strains correlated well with the radioactive metabolites of [3H] BP remaining in the alkali extract derived from the AHH assay mixture and with the increased binding of [3H] BP to microsomal protein and DNA. Benzo(a)pyrene 101-103 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 17-20 7428109-6 1980 The induction of AHH by MC in these strains correlated well with the radioactive metabolites of [3H] BP remaining in the alkali extract derived from the AHH assay mixture and with the increased binding of [3H] BP to microsomal protein and DNA. Benzo(a)pyrene 101-103 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 153-156 7428109-6 1980 The induction of AHH by MC in these strains correlated well with the radioactive metabolites of [3H] BP remaining in the alkali extract derived from the AHH assay mixture and with the increased binding of [3H] BP to microsomal protein and DNA. Benzo(a)pyrene 210-212 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 17-20 509418-5 1979 The Km of AHH for benzo[a]pyrene is decreased in the presence of caffeine. Benzo(a)pyrene 18-32 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 10-13 719813-1 1978 In a Namru mouse liver epithelial cell strain designated NMuLi, aryl hydrocarbon hydroxylase (AHH) activity peaked at 12 h post-induction with 1 microgram/ml of benzo(a)pyrene (BaP) in both confluent and growing cells. Benzo(a)pyrene 177-180 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 64-92 106274-8 1979 Aryl hydrocarbon hydroxylase (AHH) was measured in all tissue using BP as substrate. Benzo(a)pyrene 68-70 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-28 106274-8 1979 Aryl hydrocarbon hydroxylase (AHH) was measured in all tissue using BP as substrate. Benzo(a)pyrene 68-70 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 30-33 106274-11 1979 Metabolism of BP to mutagens by liver homogenates was correlated with extent of AHH induction. Benzo(a)pyrene 14-16 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 80-83 509689-1 1979 The inducibility of aryl hydrocarbon hydroxylase (AHH) by benzo[a]-pyrene (BaP) has been studied in synchronously grown cultures of mouse liver cells. Benzo(a)pyrene 58-73 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 20-48 509689-1 1979 The inducibility of aryl hydrocarbon hydroxylase (AHH) by benzo[a]-pyrene (BaP) has been studied in synchronously grown cultures of mouse liver cells. Benzo(a)pyrene 58-73 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 50-53 509689-1 1979 The inducibility of aryl hydrocarbon hydroxylase (AHH) by benzo[a]-pyrene (BaP) has been studied in synchronously grown cultures of mouse liver cells. Benzo(a)pyrene 75-78 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 20-48 509689-1 1979 The inducibility of aryl hydrocarbon hydroxylase (AHH) by benzo[a]-pyrene (BaP) has been studied in synchronously grown cultures of mouse liver cells. Benzo(a)pyrene 75-78 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 50-53 509689-2 1979 These cells (NMuLi cl 8) have low basal levels of AHH which can be induced greater than 100-fold by BaP. Benzo(a)pyrene 100-103 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 50-53 719813-1 1978 In a Namru mouse liver epithelial cell strain designated NMuLi, aryl hydrocarbon hydroxylase (AHH) activity peaked at 12 h post-induction with 1 microgram/ml of benzo(a)pyrene (BaP) in both confluent and growing cells. Benzo(a)pyrene 177-180 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 94-97 719813-4 1978 Induced AHH levels were higher in epithelial clones that were sensitive to the toxicity of BaP than in resistant clones. Benzo(a)pyrene 91-94 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 8-11 719813-5 1978 The survival fraction of clones from NMuLi and of subclones derived from a sensitive clone of NMuLi after BaP treatment was a negative exponential function of the maximal induced AHH activity in the clones. Benzo(a)pyrene 106-109 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 179-182 884659-0 1977 Induction of aryl hydrocarbon hydroxylase and forestomach tumors ben benzo(a)pyrene. Benzo(a)pyrene 69-83 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 13-41 884659-2 1977 Among all tissues examined, the forestomach showed the greatest increase of aryl hydrocarbon hydroxylase (AHH) activity following acute or chronic administration of BP. Benzo(a)pyrene 165-167 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 76-104 884659-2 1977 Among all tissues examined, the forestomach showed the greatest increase of aryl hydrocarbon hydroxylase (AHH) activity following acute or chronic administration of BP. Benzo(a)pyrene 165-167 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 106-109 884659-3 1977 Single acute doses of BP induced AHH activity in forestomach, glandular stomach, lung, and small intestine, but not in the kidney and liver of these animals. Benzo(a)pyrene 22-24 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 33-36 884659-4 1977 Similarly, after chronic administration of BP, AHH activity was inducible in the forestomach, glandular stomach, and lung, but again not in the liver. Benzo(a)pyrene 43-45 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 47-50 884659-5 1977 Although the formation of tumors is associated with greater inducibility of AHH activity in the forestomach after BP administration, the relationship between tissue inducibility of AHH activity and susceptibility to BP carcinogenesis is still not clear. Benzo(a)pyrene 114-116 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 76-79 884659-6 1977 Further studies regarding the formation of specific carcinogenic epoxides of BP in itssues both susceptible (e.g., forestomach) and resistant to BP carcinogenesis would more clearly define the relationship between AHH inducibility and BP carcinogenesis. Benzo(a)pyrene 77-79 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 214-217 890843-2 1977 Mouse epidermal homogenates contain an inducible aryl hydrocarbon hydroxylase (AHH) complex that catalyzes the formation of benzo(a)pyrene-7,8-dihydrodiol from benzo(a)pyrene (BP) as assessed by high pressure liquid chromatography (HPLC). Benzo(a)pyrene 124-138 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 49-77 890843-2 1977 Mouse epidermal homogenates contain an inducible aryl hydrocarbon hydroxylase (AHH) complex that catalyzes the formation of benzo(a)pyrene-7,8-dihydrodiol from benzo(a)pyrene (BP) as assessed by high pressure liquid chromatography (HPLC). Benzo(a)pyrene 176-178 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 49-77 975055-11 1976 Levels of AHH, the enzyme that metabolizes BaP to its cytotoxic derivatives, were only 2.4 times higher in exponentially growing than in confluent cells, suggesting that cell division was responsible for the large differential toxicity. Benzo(a)pyrene 43-46 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 10-13 975055-13 1976 The results indicate that the metabolism of BaP by AHH to produce cytotoxic metabolites, which may cause lesions that are expressed upon cell division, is responsible for the cytotoxicity of BaP to NMuLi. Benzo(a)pyrene 44-47 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 51-54 975055-13 1976 The results indicate that the metabolism of BaP by AHH to produce cytotoxic metabolites, which may cause lesions that are expressed upon cell division, is responsible for the cytotoxicity of BaP to NMuLi. Benzo(a)pyrene 191-194 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 51-54 33393179-0 2021 Pinocembrin attenuates benzo(a)pyrene-induced CYP1A1 expression through multiple pathways: An in vitro and in vivo study. Benzo(a)pyrene 23-37 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 46-52 33663268-12 2021 treatment significantly prevented the BaP-mediated expression of ArR, ARNT, and CYP1A1 proteins in the mouse stomach tissue. Benzo(a)pyrene 38-41 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 80-86 33977171-0 2021 Benzo[a]pyrene Cytotoxicity Tolerance in Testicular Sertoli Cells Involves Aryl-hydrocarbon Receptor and Cytochrome P450 1A1 Expression Deficiencies. Benzo(a)pyrene 0-14 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 105-124