PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33981385-0 2021 Kirenol Inhibits B[a]P-Induced Oxidative Stress and Apoptosis in Endothelial Cells via Modulation of the Nrf2 Signaling Pathway. Benzo(a)pyrene 17-22 NFE2 like bZIP transcription factor 2 Homo sapiens 105-109 34065697-0 2021 Quercetin and Isorhamnetin Attenuate Benzo(a)pyrene-Induced Toxicity by Modulating Detoxification Enzymes through the AhR and NRF2 Signaling Pathways. Benzo(a)pyrene 37-51 NFE2 like bZIP transcription factor 2 Homo sapiens 126-130 31255691-5 2019 Specifically, BAP upregulated targets of AhR, NRF2, and KLF4, while DBC downregulated these same targets, suggesting a chemical-specific pattern in transcriptional regulation involved in antioxidant response, potentially contributing to differences in PAH potency. Benzo(a)pyrene 14-17 NFE2 like bZIP transcription factor 2 Homo sapiens 46-50 32526964-0 2020 Baicalein Inhibits Benzo[a]pyrene-Induced Toxic Response by Downregulating Src Phosphorylation and by Upregulating NRF2-HMOX1 System. Benzo(a)pyrene 19-33 NFE2 like bZIP transcription factor 2 Homo sapiens 115-119 32526964-6 2020 In addition, BAI activated antioxidative system nuclear factor-erythroid 2-related factor-2 (NRF2) and heme oxygenase 1 (HMOX1), leading the reduction of BaP-induced ROS production. Benzo(a)pyrene 154-157 NFE2 like bZIP transcription factor 2 Homo sapiens 48-91 32526964-6 2020 In addition, BAI activated antioxidative system nuclear factor-erythroid 2-related factor-2 (NRF2) and heme oxygenase 1 (HMOX1), leading the reduction of BaP-induced ROS production. Benzo(a)pyrene 154-157 NFE2 like bZIP transcription factor 2 Homo sapiens 93-97 32526964-9 2020 These results indicate that BAI and BAI-containing herbal drugs may be useful for inhibiting the toxic effects of BaP via dual AHR-CYP1A1-inhibiting and NRF2-HMOX1-activating activities. Benzo(a)pyrene 114-117 NFE2 like bZIP transcription factor 2 Homo sapiens 153-157 32065759-3 2020 It is well-known that Nrf2 is associated increase of antioxidant enzyme catalase (CAT) or detoxification enzyme glutathione S-transferase (GST) in HaCat cells treated with B[a]P under optimal condition of hyperoxia (40% oxygenation) conditions. Benzo(a)pyrene 172-177 NFE2 like bZIP transcription factor 2 Homo sapiens 22-26 32065759-9 2020 Data suggest that optimal hyperoxia exposure of 40% oxygenation may reduce cellular toxicity induced by B[a]P in HaCat cells as evidenced by inhibition of DNA damage, free radical generation, and down-regulation of Nrf2. Benzo(a)pyrene 104-109 NFE2 like bZIP transcription factor 2 Homo sapiens 215-219 31360208-4 2019 We also noticed that BP restored Ox-LDL-stimulated HUVECs oxidative stress, by induced antioxidant gene expressions, including Heme oxygenase-1 and its upstream mediator, Nrf2, which were mediated by the activation of the phosphorylation of PI3K/Akt/mTOR. Benzo(a)pyrene 21-23 NFE2 like bZIP transcription factor 2 Homo sapiens 171-175 31387194-6 2019 BP up-regulated anti-oxidant (NQO1, Txnrd1, Nrf2) and down-regulated inflammatory (TNF-alpha and IL-6) mRNA expressions, in accompany with MAPK signaling inhibition. Benzo(a)pyrene 0-2 NFE2 like bZIP transcription factor 2 Homo sapiens 44-48 21256954-0 2011 Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. Benzo(a)pyrene 32-46 NFE2 like bZIP transcription factor 2 Homo sapiens 77-81 25946486-7 2016 These results demonstrated that the Nrf2-ARE pathway plays an important role in Sch B attenuating BaP-induced HTR cells damages in vitro. Benzo(a)pyrene 98-101 NFE2 like bZIP transcription factor 2 Homo sapiens 36-40 24588654-0 2014 Z-Ligustilide inhibits benzo(a)pyrene-induced CYP1A1 upregulation in cultured human keratinocytes via ROS-dependent Nrf2 activation. Benzo(a)pyrene 23-37 NFE2 like bZIP transcription factor 2 Homo sapiens 116-120 24588654-7 2014 L-NAC or knock-down of Nrf2 significantly attenuated the inhibitory effects of Z-Ligustilide on BaP-induced CYP1A1 upregulation in NHEKs. Benzo(a)pyrene 96-99 NFE2 like bZIP transcription factor 2 Homo sapiens 23-27 24588654-8 2014 Taken together, these findings suggest that Z-Ligustilide can suppress BaP-induced CYP1A1 upregulation through ROS-dependent Nrf2 pathway activation and may be beneficial in preventing or treating BaP-induced skin damage. Benzo(a)pyrene 71-74 NFE2 like bZIP transcription factor 2 Homo sapiens 125-129 23583300-0 2013 Benzo[a]pyrene affects Jurkat T cells in the activated state via the antioxidant response element dependent Nrf2 pathway leading to decreased IL-2 secretion and redirecting glutamine metabolism. Benzo(a)pyrene 0-14 NFE2 like bZIP transcription factor 2 Homo sapiens 108-112 21507987-10 2011 Finally, overexpression of UGTs, NRF2, or ARNT significantly decreased the amount of BaP-induced adducts in BRCA1-deficient cells. Benzo(a)pyrene 85-88 NFE2 like bZIP transcription factor 2 Homo sapiens 33-37 21714911-8 2011 Gene ontology and pathway analysis showed the involvement of various signalling pathways in response to BaP exposure, such as the Catenin/Wnt pathway in G1, the ERK pathway in G1 and S, the Nrf2 pathway in S and G2/M and the Akt pathway in G2/M. Benzo(a)pyrene 104-107 NFE2 like bZIP transcription factor 2 Homo sapiens 190-194 20498004-7 2010 Although both Nrf2 target messages nqo1 and gstp1 are upregulated by BaP in Jurkat cells, only GSTP1 is upregulated at the protein level. Benzo(a)pyrene 69-72 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 20498004-0 2010 Benzo[a]pyrene increases the Nrf2 content by downregulating the Keap1 message. Benzo(a)pyrene 0-14 NFE2 like bZIP transcription factor 2 Homo sapiens 29-33 20498004-9 2010 We concluded that BaP, but not its metabolites, increases the amount of the nuclear Nrf2 protein by downregulating the Keap1 message in Jurkat cells. Benzo(a)pyrene 18-21 NFE2 like bZIP transcription factor 2 Homo sapiens 84-88