PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18377894-4 2008 We hypothesized that gefitinib enhances B[a]P-mediated cytotoxicity by decreasing ERK1/2 activation. Benzo(a)pyrene 40-45 mitogen-activated protein kinase 3 Homo sapiens 82-88 25724555-10 2015 These data demonstrate that iRoot BP Plus can promote DPC migration and pulp repair involving the FGFR-mediated ERK 1/2, JNK, and Akt pathways. Benzo(a)pyrene 34-36 mitogen-activated protein kinase 3 Homo sapiens 112-119 25655200-8 2015 BP significantly inhibited phosphorylation of Akt and ERK-1/2, JNK and p38 in PC-3 (immunoblotting), and thus adopted a multi-pathway mechanism to exert a more potent anti-proliferative activity against prostate cancer cells than natural and synthetic SERMs. Benzo(a)pyrene 0-2 mitogen-activated protein kinase 3 Homo sapiens 54-61 25635684-14 2015 Moreover, Bet v 1 was able to induce Erk1/2 and p38 MAPK activation in BP allergics but only a slight p38 activation in normal donors. Benzo(a)pyrene 71-73 mitogen-activated protein kinase 3 Homo sapiens 37-43 21367897-0 2011 Treatment of a human papillomavirus type 31b-positive cell line with benzo[a]pyrene increases viral titer through activation of the Erk1/2 signaling pathway. Benzo(a)pyrene 69-83 mitogen-activated protein kinase 3 Homo sapiens 132-138 21367897-6 2011 Here, we show that BaP treatment activates the Ras-Raf-Mek1/2-Erk1/2 signaling pathway. Benzo(a)pyrene 19-22 mitogen-activated protein kinase 3 Homo sapiens 62-68 21367897-7 2011 The importance of Erk1/2 pathway activation to the BaP-mediated increase in viral titer was determined by Erk pathway inhibition with multiple Erk1/2 pathway inhibitors. Benzo(a)pyrene 51-54 mitogen-activated protein kinase 3 Homo sapiens 18-24 21367897-7 2011 The importance of Erk1/2 pathway activation to the BaP-mediated increase in viral titer was determined by Erk pathway inhibition with multiple Erk1/2 pathway inhibitors. Benzo(a)pyrene 51-54 mitogen-activated protein kinase 3 Homo sapiens 143-149 21367897-9 2011 These data indicate that the Erk1/2 signaling pathway plays an important role in mediating the response to BaP treatment that ultimately leads to increased viral titers. Benzo(a)pyrene 107-110 mitogen-activated protein kinase 3 Homo sapiens 29-35 23955088-4 2013 Here, we demonstrate that B[a]P induces cell migration through a lipoxygenase- and Src-dependent pathway, as well as the activation of focal adhesion kinase, Src, and the extracellular signal-regulated kinase 2 in MDA-MB-231 breast cancer cells. Benzo(a)pyrene 26-31 mitogen-activated protein kinase 3 Homo sapiens 171-210 15792794-6 2005 BP-exposure of macrophages did not enhance NF-kappaB DNA binding activity, but it activated the MAP kinase ERK1/2. Benzo(a)pyrene 0-2 mitogen-activated protein kinase 3 Homo sapiens 107-113 16699726-0 2006 Benzo[a]pyrene-induced cell cycle progression is through ERKs/cyclin D1 pathway and requires the activation of JNKs and p38 mapk in human diploid lung fibroblasts. Benzo(a)pyrene 0-14 mitogen-activated protein kinase 3 Homo sapiens 57-61 17959047-1 2007 OBJECTIVE: To study the effects of benzo(a)pyrene (BaP) on the cell cycle distribution and activities of mitogen-activated protein kinase (MAPK) signal molecules (ERK1/2, JNK1/2 and p38) in human embryo lung cells (HELF), and to investigate the relationship between alterations of MAPK protein phosphorylation and the cell cycle distributions. Benzo(a)pyrene 35-49 mitogen-activated protein kinase 3 Homo sapiens 139-143 17959047-1 2007 OBJECTIVE: To study the effects of benzo(a)pyrene (BaP) on the cell cycle distribution and activities of mitogen-activated protein kinase (MAPK) signal molecules (ERK1/2, JNK1/2 and p38) in human embryo lung cells (HELF), and to investigate the relationship between alterations of MAPK protein phosphorylation and the cell cycle distributions. Benzo(a)pyrene 35-49 mitogen-activated protein kinase 3 Homo sapiens 163-169 17959047-1 2007 OBJECTIVE: To study the effects of benzo(a)pyrene (BaP) on the cell cycle distribution and activities of mitogen-activated protein kinase (MAPK) signal molecules (ERK1/2, JNK1/2 and p38) in human embryo lung cells (HELF), and to investigate the relationship between alterations of MAPK protein phosphorylation and the cell cycle distributions. Benzo(a)pyrene 35-49 mitogen-activated protein kinase 3 Homo sapiens 281-285 17959047-1 2007 OBJECTIVE: To study the effects of benzo(a)pyrene (BaP) on the cell cycle distribution and activities of mitogen-activated protein kinase (MAPK) signal molecules (ERK1/2, JNK1/2 and p38) in human embryo lung cells (HELF), and to investigate the relationship between alterations of MAPK protein phosphorylation and the cell cycle distributions. Benzo(a)pyrene 51-54 mitogen-activated protein kinase 3 Homo sapiens 139-143 17959047-1 2007 OBJECTIVE: To study the effects of benzo(a)pyrene (BaP) on the cell cycle distribution and activities of mitogen-activated protein kinase (MAPK) signal molecules (ERK1/2, JNK1/2 and p38) in human embryo lung cells (HELF), and to investigate the relationship between alterations of MAPK protein phosphorylation and the cell cycle distributions. Benzo(a)pyrene 51-54 mitogen-activated protein kinase 3 Homo sapiens 163-169 17959047-1 2007 OBJECTIVE: To study the effects of benzo(a)pyrene (BaP) on the cell cycle distribution and activities of mitogen-activated protein kinase (MAPK) signal molecules (ERK1/2, JNK1/2 and p38) in human embryo lung cells (HELF), and to investigate the relationship between alterations of MAPK protein phosphorylation and the cell cycle distributions. Benzo(a)pyrene 51-54 mitogen-activated protein kinase 3 Homo sapiens 281-285 17959047-2 2007 METHODS: The phosphorylation of MAPK were induced by exposing HELF cells to BaP at 0.1, 0.5, 2.5 and 12.5 micromol/L. Benzo(a)pyrene 76-79 mitogen-activated protein kinase 3 Homo sapiens 32-36 17959047-4 2007 And the flow cytometry assay was used to measure the cell cycle effects in HELF cells after treatment with 2.5 micromol/L BaP for 24 h. RESULTS: The phosphorylation levels of ERK1/2, JNK1/2 and p38 were significantly increased through BaP exposure. Benzo(a)pyrene 122-125 mitogen-activated protein kinase 3 Homo sapiens 175-181 17959047-7 2007 Three chemical inhibitors of MAPK (AG126, SP600125 and SB203580) could significantly inhibit the cell cycle alteration because of BaP treatment. Benzo(a)pyrene 130-133 mitogen-activated protein kinase 3 Homo sapiens 29-33 17959047-8 2007 CONCLUSION: ERK1/2, JNK1/2 and p38 could positively regulate the BaP independently induced cell cycle alterations. Benzo(a)pyrene 65-68 mitogen-activated protein kinase 3 Homo sapiens 12-18 34329126-0 2021 Integration of data from the cell-based ERK1/2 ELISA and the Comparative Toxicogenomics Database deciphers the potential mode of action of bisphenol A and benzo(a)pyrene in lung neoplasm. Benzo(a)pyrene 155-169 mitogen-activated protein kinase 3 Homo sapiens 40-46 15144225-7 2004 Western blot analysis showed that benzo[a]pyrene could induce the phosphorylation of ERK1/2 and Akt (PI3K downstream effector) in osteoblasts. Benzo(a)pyrene 34-48 mitogen-activated protein kinase 3 Homo sapiens 85-91 34329126-4 2021 A549 cells were exposed to bisphenol A (BPA), benzo(a)pyrene (BaP), tributyltin (TBT), and ibuprofen from 10-12 M to 10-5 M. Results show that BPA, BaP, and TBT can activate ERK1/2 in A549 cells. Benzo(a)pyrene 46-60 mitogen-activated protein kinase 3 Homo sapiens 174-180 34329126-4 2021 A549 cells were exposed to bisphenol A (BPA), benzo(a)pyrene (BaP), tributyltin (TBT), and ibuprofen from 10-12 M to 10-5 M. Results show that BPA, BaP, and TBT can activate ERK1/2 in A549 cells. Benzo(a)pyrene 62-65 mitogen-activated protein kinase 3 Homo sapiens 174-180 34329126-4 2021 A549 cells were exposed to bisphenol A (BPA), benzo(a)pyrene (BaP), tributyltin (TBT), and ibuprofen from 10-12 M to 10-5 M. Results show that BPA, BaP, and TBT can activate ERK1/2 in A549 cells. Benzo(a)pyrene 148-151 mitogen-activated protein kinase 3 Homo sapiens 174-180 34329126-5 2021 We selected BPA and BaP to elucidate the molecular events connecting chemical exposure, ERK1/2 signaling, phenotypes, and lung neoplasm (LN) using CTD. Benzo(a)pyrene 20-23 mitogen-activated protein kinase 3 Homo sapiens 88-94 34547448-5 2021 Mancozeb, benzo(a)pyrene, and bisphenol A stimulated ERK1/2 up to ~2- (HepG2) and 1.5 (RTL-W1)-fold, though the kinetics differed between chemicals and cell lines. Benzo(a)pyrene 10-24 mitogen-activated protein kinase 3 Homo sapiens 53-59 34547448-6 2021 Bisphenol A and benzo(a)pyrene were the most potent concentration-wise, altering ERK1/2 activity in pM (HepG2) to nM (RTL-W1) range. Benzo(a)pyrene 16-30 mitogen-activated protein kinase 3 Homo sapiens 81-87