PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12054747-4	2002	BaP-treated cells exhibited significant decreases in beta-catenin and cadherin protein levels, while vinculin levels remained unchanged relative to control.	Benzo(a)pyrene	0-3	catenin beta 1	Homo sapiens	53-65	
28862656-5	2017	BP compounds increased the transcriptional activity of the TOPflash and glioma-associated oncogene homolog zinc finger protein (Gli) promoters in reporter assays and increased the expression of Gli-1, Gli-2, Smoothened (SMO), and beta-catenin by RT-PCR.	Benzo(a)pyrene	0-2	catenin beta 1	Homo sapiens	230-242	
25805023-3	2015	In the present study, we investigated the impact of inhibition of Wnt/beta-catenin pathway on metabolism and genotoxicity of benzo[a]pyrene (BaP), a highly mutagenic polycyclic aromatic hydrocarbon and an efficient ligand of the aryl hydrocarbon receptor, which is known as a primary regulator of CYP1 expression, in cellular models derived from colorectal tumours.	Benzo(a)pyrene	141-144	catenin beta 1	Homo sapiens	70-82	
25805023-0	2015	Inhibition of beta-catenin signalling promotes DNA damage elicited by benzo[a]pyrene in a model of human colon cancer cells via CYP1 deregulation.	Benzo(a)pyrene	70-84	catenin beta 1	Homo sapiens	14-26	
25805023-3	2015	In the present study, we investigated the impact of inhibition of Wnt/beta-catenin pathway on metabolism and genotoxicity of benzo[a]pyrene (BaP), a highly mutagenic polycyclic aromatic hydrocarbon and an efficient ligand of the aryl hydrocarbon receptor, which is known as a primary regulator of CYP1 expression, in cellular models derived from colorectal tumours.	Benzo(a)pyrene	125-139	catenin beta 1	Homo sapiens	70-82	
25805023-4	2015	We observed that a synthetic inhibitor of beta-catenin, JW74, significantly increased formation of BaP-induced DNA adducts in both colorectal adenoma and carcinoma-derived cell lines.	Benzo(a)pyrene	99-102	catenin beta 1	Homo sapiens	42-54	
25805023-5	2015	Using the short interfering RNA (siRNA) targeting beta-catenin, we then found that beta-catenin knockdown in HCT116 colon carcinoma cells significantly enhanced formation of covalent DNA adducts by BaP and histone H2AX phosphorylation, as detected by (32)P-postlabelling technique and immunocytochemistry, respectively, and it also induced expression of DNA damage response genes, such as CDKN1A or DDB2.	Benzo(a)pyrene	198-201	catenin beta 1	Homo sapiens	83-95	
25805023-6	2015	The increased formation of DNA adducts formed by BaP upon beta-catenin knockdown corresponded with enhanced production of major BaP metabolites, as well as with an increased expression/activity of CYP1 enzymes.	Benzo(a)pyrene	49-52	catenin beta 1	Homo sapiens	58-70	
25805023-6	2015	The increased formation of DNA adducts formed by BaP upon beta-catenin knockdown corresponded with enhanced production of major BaP metabolites, as well as with an increased expression/activity of CYP1 enzymes.	Benzo(a)pyrene	128-131	catenin beta 1	Homo sapiens	58-70	
25805023-8	2015	Taken together, the present results indicated that the siRNA-mediated inhibition of beta-catenin signalling, which is aberrantly activated in a majority of colorectal cancers, modulated genotoxicity of dietary carcinogen BaP in colon cell model in vitro, via a mechanism involving up-regulation of CYP1 expression and activity.	Benzo(a)pyrene	221-224	catenin beta 1	Homo sapiens	84-96