PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26335255-1 2016 The expression of the tumor suppressor p53 can influence the bioactivation of, and DNA damage induced by, the environmental carcinogen benzo[a]pyrene, indicating a role for p53 in its cytochrome P450 (CYP)-mediated biotransformation. Benzo(a)pyrene 135-149 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 184-199 26335255-1 2016 The expression of the tumor suppressor p53 can influence the bioactivation of, and DNA damage induced by, the environmental carcinogen benzo[a]pyrene, indicating a role for p53 in its cytochrome P450 (CYP)-mediated biotransformation. Benzo(a)pyrene 135-149 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 201-204 6438922-0 1984 Specificity of four forms of cytochrome P-450 in the metabolic activation of several aromatic amines and benzo[a]pyrene. Benzo(a)pyrene 105-119 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 29-45 26004618-9 2015 Further, BP treatment brought about a significant increase in the activities of drug metabolizing enzymes (cytochrome P450 and b5). Benzo(a)pyrene 9-11 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 107-129 11596290-8 1997 The effects of SY-640 on cytochrome P-450 and its formation of MI complex with cytochrome P-450 may partially explain why SY-640 could inhibit covalent-binding of BP to mouse hepatocyte DNA in vitro. Benzo(a)pyrene 163-165 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 25-41 11596290-8 1997 The effects of SY-640 on cytochrome P-450 and its formation of MI complex with cytochrome P-450 may partially explain why SY-640 could inhibit covalent-binding of BP to mouse hepatocyte DNA in vitro. Benzo(a)pyrene 163-165 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 79-95 2097279-0 1990 [Effect of monoclonal antibody against methylcholanthrene-induced cytochrome P-450 forms on benzo(a)pyrene metabolism in hepatic microsomes of C57BL/10 mice]. Benzo(a)pyrene 92-106 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 66-82 3970724-2 1985 Cytochrome P-450-dependent monooxygenases were induced in mouse lung by intratracheal instillation of BaP, Aroclor-1254, or coal gas condensate (CGC) 24 hr before instillation of [3H]BaP, [3H]-2-AA, [14C]-1-NP, or [14C]PNDO. Benzo(a)pyrene 102-105 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 0-16 3970724-2 1985 Cytochrome P-450-dependent monooxygenases were induced in mouse lung by intratracheal instillation of BaP, Aroclor-1254, or coal gas condensate (CGC) 24 hr before instillation of [3H]BaP, [3H]-2-AA, [14C]-1-NP, or [14C]PNDO. Benzo(a)pyrene 183-186 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 0-16 11577022-6 2001 CYP-encoded aryl hydrocarbon hydroxylase activity was higher in Ahr(-/-) VSMCs under constitutive conditions and induced by benzo(a)pyrene in Ahr(+/+) and Ahr(-/-) VSMCs. Benzo(a)pyrene 124-138 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 0-3 11201666-0 2000 Cytochrome P450-dependent binding of 7,12-dimethylbenz[a]anthracene (DMBA) and benzo[a]pyrene (B[a]P) in murine heart, lung, and liver endothelial cells. Benzo(a)pyrene 79-93 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 0-15 1581531-6 1992 32P-Postlabeling analysis of DNA adducts produced following topical administration of benzo[a]pyrene to mouse skin suggests that cytochrome P-450 plays a major role in its metabolism to DNA binding derivatives. Benzo(a)pyrene 86-100 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 129-145 1581533-12 1992 The stereochemistry of epoxidation of the enantiomers of BP-7,8-diol indicates that cytochrome P-450 catalyzes the terminal activation step of benzo[a]pyrene activation to an ultimate carcinogen in mouse skin, a target organ for its carcinogenic activity. Benzo(a)pyrene 143-157 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 84-100 3103261-0 1987 Differential induction of cytochrome P-450 catalyzed activities by polychlorinated biphenyls and benzo [a]pyrene in B6C3F1 mouse liver and lung. Benzo(a)pyrene 97-112 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 26-42 2830152-7 1987 Menadione inhibited BaP oxygenation in microsomal preparations, by siphoning off electrons from cytochrome P-450, while addition of UDPGA reversed this effect by glucuronidation of menadiol. Benzo(a)pyrene 20-23 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 96-112 2422427-7 1986 Reduced hepatic cytochrome P-450 contents correlated with decreased abilities of liver homogenates to metabolically activate benzo [a]pyrene (CAS: 50-32-8) and N-acetyl-2-aminofluorene (CAS: 53-96-3), as scored in an Ames Salmonella typhimurium revertant assay. Benzo(a)pyrene 125-140 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 16-32 6331534-4 1984 Cytochrome P-450 (Mr = 51 000) elicits a low spin signal and reveals a high catalytic activity toward aminopyrine and a low catalytic activity toward benz(a)pyrene. Benzo(a)pyrene 150-163 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 0-16 6319113-5 1983 The rates of individual BaP metabolite production are increased in lungs from mice pretreated with Aroclor 1254 or beta-naphthoflavone, substances known to induce increased synthesis of cytochrome P-450. Benzo(a)pyrene 24-27 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 186-202 6317167-5 1984 Since the gross microsomal cytochrome P-450 content was not significantly affected by the treatment, the change of regioselectivity in BP metabolism was probably due to the alteration of cytochrome P-450 isozyme composition by dietary BHA. Benzo(a)pyrene 135-137 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 187-203 6319113-7 1983 These results support the existence of significant cytochrome P-450-dependent and conjugative BaP metabolism in the intact mouse lung, similar to that examined in other species, and capable of contributing to the systemic metabolism of this carcinogen. Benzo(a)pyrene 94-97 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 51-67 31612222-6 2019 In contrast, CYP-catalysed BaP-DNA adduct levels were ~10-fold higher in POR KO Hepa1c1c7 cells than in WT Hepa1c1c7 cells, in concordance with the presence of higher levels of BaP metabolite (e.g. BaP-7,8-dihydrodiol) in the medium of cultured BaP-exposed POR KO Hepa1c1c7 cells. Benzo(a)pyrene 177-180 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 13-16 497269-1 1979 It was shown that metyrapone, the inhibitor of arylhydrocarbonhydroxylase, taken at concentrations equimolar to that of cytochrome P-450 non-competitively inhibits the hydroxylation of 3,4-benzpyrene in the liver microsomes of inbred mice of the C57BL/6 and AKR strains. Benzo(a)pyrene 185-199 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 120-136 31612222-0 2019 Deletion of cytochrome P450 oxidoreductase enhances metabolism and DNA adduct formation of benzo[a]pyrene in Hepa1c1c7 cells. Benzo(a)pyrene 91-105 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 12-27 31612222-1 2019 The environmental carcinogen benzo[a]pyrene (BaP) is presumed to exert its genotoxic effects after metabolic activation by cytochrome P450 (CYP) enzymes. Benzo(a)pyrene 29-43 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 123-138 31612222-1 2019 The environmental carcinogen benzo[a]pyrene (BaP) is presumed to exert its genotoxic effects after metabolic activation by cytochrome P450 (CYP) enzymes. Benzo(a)pyrene 29-43 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 140-143 31612222-1 2019 The environmental carcinogen benzo[a]pyrene (BaP) is presumed to exert its genotoxic effects after metabolic activation by cytochrome P450 (CYP) enzymes. Benzo(a)pyrene 45-48 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 123-138 31612222-1 2019 The environmental carcinogen benzo[a]pyrene (BaP) is presumed to exert its genotoxic effects after metabolic activation by cytochrome P450 (CYP) enzymes. Benzo(a)pyrene 45-48 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 140-143 31612222-2 2019 However, studies using the Hepatic Reductase Null (HRN) mouse model, in which cytochrome P450 oxidoreductase (POR), the electron donor to CYP enzymes, is deleted specifically in hepatocytes, have shown that loss of hepatic POR-mediated CYP function leads to greater BaP-DNA adduct formation in livers of these mice than in wild-type (WT) mice. Benzo(a)pyrene 266-269 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 78-93 31612222-6 2019 In contrast, CYP-catalysed BaP-DNA adduct levels were ~10-fold higher in POR KO Hepa1c1c7 cells than in WT Hepa1c1c7 cells, in concordance with the presence of higher levels of BaP metabolite (e.g. BaP-7,8-dihydrodiol) in the medium of cultured BaP-exposed POR KO Hepa1c1c7 cells. Benzo(a)pyrene 27-30 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 13-16 31612222-6 2019 In contrast, CYP-catalysed BaP-DNA adduct levels were ~10-fold higher in POR KO Hepa1c1c7 cells than in WT Hepa1c1c7 cells, in concordance with the presence of higher levels of BaP metabolite (e.g. BaP-7,8-dihydrodiol) in the medium of cultured BaP-exposed POR KO Hepa1c1c7 cells. Benzo(a)pyrene 177-180 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 13-16 31612222-6 2019 In contrast, CYP-catalysed BaP-DNA adduct levels were ~10-fold higher in POR KO Hepa1c1c7 cells than in WT Hepa1c1c7 cells, in concordance with the presence of higher levels of BaP metabolite (e.g. BaP-7,8-dihydrodiol) in the medium of cultured BaP-exposed POR KO Hepa1c1c7 cells. Benzo(a)pyrene 177-180 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 13-16 31612222-8 2019 These results indicate that CYP enzymes may play a more important role in the detoxication of BaP, as opposed to its bioactivation. Benzo(a)pyrene 94-97 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 28-31