PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19961320-1 2010 Human CYP1A2 is one of the major CYPs in human liver and metabolizes a number of clinical drugs (e.g., clozapine, tacrine, tizanidine, and theophylline; n > 110), a number of procarcinogens (e.g., benzo[a]pyrene and aromatic amines), and several important endogenous compounds (e.g., steroids). Benzo(a)pyrene 200-214 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 6-12 20542099-3 2010 When analyzing the effect of BaP on the induction of CYP1 enzymes participating in the metabolic activation of PAHs in LNCaP cells, we found that BaP induced expression of CYP1A1 and CYP1A2, but not CYP1B1 enzyme. Benzo(a)pyrene 146-149 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 183-189 23626760-3 2013 Since ethical constraints do not permit methodologically rigorous studies in humans, this question was addressed by investigating the effect of the prototypical inducer benzo[a]pyrene (BP) on CYP1A1 and CYP1A2 in cirrhotic rats stratified according to the severity of liver dysfunction. Benzo(a)pyrene 169-183 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 203-209 23626760-3 2013 Since ethical constraints do not permit methodologically rigorous studies in humans, this question was addressed by investigating the effect of the prototypical inducer benzo[a]pyrene (BP) on CYP1A1 and CYP1A2 in cirrhotic rats stratified according to the severity of liver dysfunction. Benzo(a)pyrene 185-187 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 203-209 19501186-6 2009 Among these transformants, benzo(a)pyrene-induced or cyclophosphamide-produced micronucleus (MN) frequency was markedly increased in transformants expressing CYP1A2 or CYP2C9, respectively. Benzo(a)pyrene 27-41 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 158-164 19406224-7 2009 Gene expression analysis at 4 and 24h following benzo(a)pyrene exposure revealed the induction of cyp1a1, cyp1a2, and cyp1b1 in FE1 cells and lung isolates. Benzo(a)pyrene 48-62 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 106-112 19919601-1 2010 Administration of melatonin to rodents decreases the incidence of tumorigenesis initiated by benzo[a]pyrene or 7,12-dimethylbenz[a]anthracene, which requires bioactivation by cytochrome P450 enzymes, such as CYP1A1, CYP1A2 and CYP1B1, to produce carcinogenic metabolites. Benzo(a)pyrene 93-107 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 216-222 19919601-7 2010 Additional experiments indicated that melatonin decreased benzo[a]pyrene hydroxylation catalyzed by hepatic microsomes and CYP1A2 but not by CYP1A1 or CYP1B1. Benzo(a)pyrene 58-72 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 123-129 19590965-1 2009 Human CYP1A2 is one of the major CYPs in human liver and metabolizes a variety of clinically important drugs (e.g., clozapine, tacrine, tizanidine, and theophylline), a number of procarcinogens (e.g. benzo[a]pyrene and aflatoxin B(1)), and several important endogenous compounds (e.g. steroids and arachidonic acids). Benzo(a)pyrene 200-214 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 6-12 19202560-0 2009 Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene. Benzo(a)pyrene 77-91 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 50-56 19202560-6 2009 The aim of the study was to determine whether the differences in the isothiocyanate structure change its ability to inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene in HepG2 and Mcf7 cells. Benzo(a)pyrene 162-176 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 135-141 18372000-4 2008 In this study, we assessed the effects of CYP1 enzymes (CYP1A1, CYP1A2 and CYP1B1) on BaP-induced AhR transactivation and DNA adduct formation in HEK293 cells and HepG2 cells. Benzo(a)pyrene 86-89 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 64-70 18372000-6 2008 Expression of CYP1A1 and CYP1A2, but not CYP1B1, inhibited DNA adduct formation in BaP-treated HepG2 cells. Benzo(a)pyrene 83-86 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 25-31 18372000-10 2008 Dynamic expression of CYP1A1, CYP1A2 and CYP1B1 along with expression of other enzymes such as epoxide hydrolase and phase II enzymes may determine the detoxification or metabolic activation of BaP. Benzo(a)pyrene 194-197 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 30-36 4015401-7 1985 Induction of aryl hydrocarbon hydroxylase activity in the cultures with 5,6-benzoflavone (10 microM) or benz(a)anthracene (10 microM) caused a decrease (75 and 46% of the control value respectively) in BP-DNA binding. Benzo(a)pyrene 202-204 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 13-41 17261025-5 2007 Using benzo[a]pyrene as a test substrate, enzyme activity for producing DNA damage in the arrays was found in the order CYP1B1 > CYP1A2 > CYP1A1 > CYP2E1 > myoglobin, the same as the order of their metabolic activity. Benzo(a)pyrene 6-20 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 132-138 16970932-5 2006 Both beta-carotene and AC at 20 microM significantly enhanced DNA strand breaks and CYP1A2 expression induced by BaP. Benzo(a)pyrene 113-116 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 84-90 16970932-9 2006 Quercetin significantly inhibited the DNA strand breaks and the increase in CYP1A2 protein induced by AC or beta-carotene in combination with BaP or by AC alone. Benzo(a)pyrene 142-145 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 76-82 14743400-1 2004 Constitutive and benzo[a]pyrene (B[a]P) inducible expression of CYP1A1 and CYP1A2 in prostate cancer and normal prostate epithelial cells were examined by immunoblotting. Benzo(a)pyrene 17-31 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 75-81 2351129-1 1990 The metabolism of benzo[a]pyrene is mediated by the mixed function oxidase system including the cytochrome P450-dependent aryl hydrocarbon hydroxylase. Benzo(a)pyrene 18-32 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 122-150 3143724-4 1988 Since aryl hydrocarbon hydroxylase is the principle enzyme activity which converts benzo(a)pyrene to toxic hydroxylated forms, the regulation of cytochrome P-450IA1 expression, the gene encoding this enzyme activity in MCF-7 cells, was examined. Benzo(a)pyrene 83-97 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 6-34 4077222-2 1985 The aryl-hydrocarbon hydroxylase activity was examined by metabolism of benzo[a]pyrene in microsomes prepared from intimal and smooth muscle cell scrapings of the hog thoracic aorta. Benzo(a)pyrene 72-86 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 4-32 16773535-7 2006 mRNA expression of CYP1A1 or CYP1A2 induced by the promutagen benzo[a]pyrene was significantly down-regulated by EGCG but not by GTE. Benzo(a)pyrene 62-76 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 29-35 14729370-0 2004 Metabolic activation of 10-aza-substituted benzo[a]pyrene by cytochrome P450 1A2 in human liver microsomes. Benzo(a)pyrene 43-57 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 61-80 14729370-7 2004 With regard to the proposal that BaP may be activated by human CYP1A1, our results suggest that the nitrogen-substitution at position-10 of BaP may cause the CYP enzyme-specificity in metabolic activation to change from CYP1A1 to CYP1A2. Benzo(a)pyrene 33-36 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 230-236 14729370-7 2004 With regard to the proposal that BaP may be activated by human CYP1A1, our results suggest that the nitrogen-substitution at position-10 of BaP may cause the CYP enzyme-specificity in metabolic activation to change from CYP1A1 to CYP1A2. Benzo(a)pyrene 140-143 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 230-236 9152602-5 1997 CYP1B1 catalyzed benzo[a]pyrene 3-hydroxylation at rates lower than those of CYP1A1 but higher than those of CYP1A2. Benzo(a)pyrene 17-31 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 109-115 7581497-2 1995 Here, the application of rat and human CYP1A1 and CYP1A2 is demonstrated for comparative studies on the oxidation of polycyclic aromatic hydrocarbons, such as phenanthrene, benz[a]anthracene, and benzo[a]pyrene. Benzo(a)pyrene 196-210 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 50-56 1654865-1 1991 The Ah (aromatic hydrocarbon) receptor mediates induction of aryl hydrocarbon hydroxylase (AHH; an enzyme activity associated with cytochrome P450IA1) by polycyclic aromatic hydrocarbon carcinogens such as 3-methylcholanthrene (MC) and benzo[a]pyrene (BP) and the halogenated toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Benzo(a)pyrene 236-250 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 61-89 1654865-1 1991 The Ah (aromatic hydrocarbon) receptor mediates induction of aryl hydrocarbon hydroxylase (AHH; an enzyme activity associated with cytochrome P450IA1) by polycyclic aromatic hydrocarbon carcinogens such as 3-methylcholanthrene (MC) and benzo[a]pyrene (BP) and the halogenated toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Benzo(a)pyrene 236-250 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 91-94 1654865-1 1991 The Ah (aromatic hydrocarbon) receptor mediates induction of aryl hydrocarbon hydroxylase (AHH; an enzyme activity associated with cytochrome P450IA1) by polycyclic aromatic hydrocarbon carcinogens such as 3-methylcholanthrene (MC) and benzo[a]pyrene (BP) and the halogenated toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Benzo(a)pyrene 252-254 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 61-89 1654865-1 1991 The Ah (aromatic hydrocarbon) receptor mediates induction of aryl hydrocarbon hydroxylase (AHH; an enzyme activity associated with cytochrome P450IA1) by polycyclic aromatic hydrocarbon carcinogens such as 3-methylcholanthrene (MC) and benzo[a]pyrene (BP) and the halogenated toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Benzo(a)pyrene 252-254 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 91-94 3684951-7 1987 With human lymphocytes the method has proven to be a good indicator of "aryl hydrocarbon hydroxylase" (AHH) activity, correlating well with AHH assays using benzo(alpha)pyrene (BP) as a substrate. Benzo(a)pyrene 177-179 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 72-100 3011254-14 1986 Aryl hydrocarbon hydroxylase, the major enzyme induced under control of the Ah receptor, plays an important role in the metabolism of several carcinogens including polycyclic aromatic hydrocarbons such as benzo(a)pyrene. Benzo(a)pyrene 205-219 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 0-28 7056021-1 1982 The induced activity of aryl hydrocarbon hydroxylase (AHH), measured by the metabolism of benzo[a]pyrene to fluorescent products in cultured human lymphocytes, shows a strong seasonal variation. Benzo(a)pyrene 90-104 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 24-52 6477826-1 1984 Arylhydrocarbon-hydroxylase (AHH) is a cytochrome P-450-dependent polysubstrate mono-oxygenase which plays an important role in converting some compounds (e.g. benzo[a]pyrene) to highly reactive carcinogenic species. Benzo(a)pyrene 160-174 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 0-27 7056021-1 1982 The induced activity of aryl hydrocarbon hydroxylase (AHH), measured by the metabolism of benzo[a]pyrene to fluorescent products in cultured human lymphocytes, shows a strong seasonal variation. Benzo(a)pyrene 90-104 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 54-57 1026852-4 1976 Injection of benzo(a)pyrene at two dose levels caused a much greater increase in both liver and lung aryl hydrocarbon hydroxylase than smoking. Benzo(a)pyrene 13-27 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 101-129 7333581-1 1981 Polycyclic aromatic hydrocarbon-inducible monooxygenase directed toward the substrate benzo(a)pyrene, i.e., "aryl hydrocarbon hydroxylase", was monitored in cell hybrids formed from mouse RAG cells and several human fibroblasts lines. Benzo(a)pyrene 86-100 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 109-137 711851-10 1978 Assay of several defined constituents of coal tar for AHH induction showed that BP was the most potent inducer of AHH tested. Benzo(a)pyrene 80-82 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 54-57 711851-10 1978 Assay of several defined constituents of coal tar for AHH induction showed that BP was the most potent inducer of AHH tested. Benzo(a)pyrene 80-82 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 114-117 697921-0 1978 Ellipticines as potent inhibitors of aryl hydrocarbon hydroxylase: their binding to microsomal cytochromes P450 and protective effect against benzo(a)pyrene mutagenicity. Benzo(a)pyrene 142-156 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 37-65 31112310-4 2020 First, 1-methylpyrene, 1-hydroxymethylpyrene, benzo[a]pyrene, and aflatoxin B1 significantly induced micronuclei in V79-hCYP1A2-hSULT1A1, V79-hSULT1A1, V79-hCYP1A1, and V79-hCYP1A2 cells, respectively. Benzo(a)pyrene 46-60 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 120-127 31112310-4 2020 First, 1-methylpyrene, 1-hydroxymethylpyrene, benzo[a]pyrene, and aflatoxin B1 significantly induced micronuclei in V79-hCYP1A2-hSULT1A1, V79-hSULT1A1, V79-hCYP1A1, and V79-hCYP1A2 cells, respectively. Benzo(a)pyrene 46-60 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 173-180 31112310-9 2020 Benzo[a]pyrene induced micronuclei in V79-Mz communicating with V79-hCYP1A1 via porous membranes, whereas aflatoxin B1 was inactive in V79-Mz communicating with V79-hCYP1A2. Benzo(a)pyrene 0-14 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 165-172 30122317-11 2018 Our data also demonstrated that Benzo(a)pyrene (BaP) induced up to 100 folds of mRNA expression of CYP1A1 or CYP1A2 in CR-HNBE cells. Benzo(a)pyrene 32-46 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 109-115 26552516-0 2016 Measurement of human CYP1A2 induction by inhalation exposure to benzo(a)pyrene based on in vivo isotope breath method. Benzo(a)pyrene 64-78 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 21-27 26552516-2 2016 To date, few studies have investigated in vivo CYP1A2 induction in humans and its relationship to polycylic aromatic hydrocarbons (PAHs) like benzo(a)pyrene (BaP). Benzo(a)pyrene 142-156 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 47-53 26552516-2 2016 To date, few studies have investigated in vivo CYP1A2 induction in humans and its relationship to polycylic aromatic hydrocarbons (PAHs) like benzo(a)pyrene (BaP). Benzo(a)pyrene 158-161 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 47-53 26552516-8 2016 Hepatic CYP1A2 activity/induction level was not effected by inhaled BaP but was altered by ingestion of BaP. Benzo(a)pyrene 104-107 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 8-14