PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3590196-1 1986 Percutaneous absorption of 14C-labeled benzo[a]pyrene (BaP) was studied in five-day in vivo and in vitro experiments with female Sprague-Dawley rats following single topical doses of 9-10 micrograms/cm2. Benzo(a)pyrene 39-53 prohibitin 2 Rattus norvegicus 55-58 3943078-1 1986 Male Swiss mice and Wistar rats were treated topically with 250 nmol/mouse and 750 nmol/rat of [3H]benzo[a]pyrene ([3H]BaP). Benzo(a)pyrene 99-113 prohibitin 2 Rattus norvegicus 119-122 2433367-1 1986 Benzo[a]pyrene (BaP) metabolites were assessed, with and without enzymatic activation by rat liver S9, for their inhibitory activities on influenza virus induction of interferon-alpha/beta (IFN-alpha/beta) in mammalian (LLC-MK2) cell cultures. Benzo(a)pyrene 0-14 prohibitin 2 Rattus norvegicus 16-19 4017178-1 1985 To determine the relationship of the benzo[a]pyrene (BaP)-DNA adducts formed in the activator cells of a cell-mediated mutation assay to the adducts formed in the target cells and to mutation induction, irradiated second passage Wistar rat embryo (WRE) cells and V79 Chinese hamster lung cells were exposed to [3H]BaP for 5, 24 and 48 h under the conditions of a cell-mediated mutation assay. Benzo(a)pyrene 37-51 prohibitin 2 Rattus norvegicus 53-56 2996532-1 1985 Sonic disrupted mitoplasts from 3-methylcholanthrene (MCA) treated rats can catalyze the formation of benzo(a)pyrene (BaP) adducts with calf thymus DNA in the presence of an NADPH generating system. Benzo(a)pyrene 102-116 prohibitin 2 Rattus norvegicus 118-121 6136322-1 1983 Treatment of adult female rats with a single dose of benzo[a]pyrene (BaP) fails to initiate preneoplastic enzyme-altered islands in their livers. Benzo(a)pyrene 53-67 prohibitin 2 Rattus norvegicus 69-72 25490995-1 2015 Benzo(a)pyrene [B(a)P] is ubiquitous in the environment. Benzo(a)pyrene 0-14 prohibitin 2 Rattus norvegicus 16-21 30982342-2 2019 Benzo(a)pyrene (BaP) is one of the most representative air pollutants and has aroused wide concern because of its strong carcinogenicity. Benzo(a)pyrene 0-14 prohibitin 2 Rattus norvegicus 16-19 29649501-2 2018 The synthetic estrogen 17alpha-ethinylestradiol (EE2) and the environmental carcinogen benzo[a]pyrene (BaP) are exogenous EDs whereas the estrogenic hormone 17beta-estradiol is a natural endogenous ED. Benzo(a)pyrene 87-101 prohibitin 2 Rattus norvegicus 103-106 20708262-3 2010 In this study, we evaluated the protective effects of PE on rats exposed to benzo[a]pyrene (BaP). Benzo(a)pyrene 76-90 prohibitin 2 Rattus norvegicus 92-95 22357517-1 2011 OBJECTIVE: To observe the effects of Benzo(a)pyrene (BaP) on apoptosis of neuronal cells and expression of Bcl-2 and Bax proteins and to explore the mechanism of neurotoxicity induced by BaP in rats. Benzo(a)pyrene 37-51 prohibitin 2 Rattus norvegicus 53-56 19497421-3 2009 The present study aimed to characterize expression/activities of enzymes of two major pathways involved in the metabolism of benzo[a]pyrene (BaP): cytochrome P450 (CYP) family 1 enzymes and cytosolic aldo-keto reductases (AKRs). Benzo(a)pyrene 125-139 prohibitin 2 Rattus norvegicus 141-144 20195826-1 2010 Benzo[a]pyrene (BaP) is a known carcinogen. Benzo(a)pyrene 0-14 prohibitin 2 Rattus norvegicus 16-19 16906435-2 2007 Naphthalene, phenanthrene, pyrene, chrysene, and benzo[a]pyrene (BaP) were administered to rats for 3 days (25-128 mg/kg/day) and the responses compared with those of model inducers. Benzo(a)pyrene 49-63 prohibitin 2 Rattus norvegicus 65-68 15993149-1 2005 In this study, the polycyclic aromatic hydrocarbons, benzo[a]pyrene (BaP) and pyrene, were subjected to temporal ozonation. Benzo(a)pyrene 53-67 prohibitin 2 Rattus norvegicus 69-72 12587739-1 2002 In order to determine the organ specific carcinogenicity of benzo(a)pyrene (B(a)P), its metabolites, formed in vitro by incubation with the homogenates from liver, lungs, kidneys, intestine and brain of rats, were isolated by TLC and spectroscopy. Benzo(a)pyrene 60-74 prohibitin 2 Rattus norvegicus 76-81 14729368-7 2004 Lung S9 from various exposure groups was isolated from tissue homogenates and characterized for metabolic activity in activating 2-aminoanthracene (2-AA) and benzo[a]pyrene (BaP) mutagenicity using the Ames test with Salmonella typhimurium YG1024 and YG1029. Benzo(a)pyrene 158-172 prohibitin 2 Rattus norvegicus 174-177 14520510-1 2004 The aim of this study was to investigate the electrophilic tissue burden (ETB) formation, assessed as covalent binding of the ultimate carcinogen benzo( a)pyrene diolepoxide (BaPDE) with cellular proteins, in liver, lung and heart, as well as with haemoglobin (Hb) following repeated exposure to binary mixtures of benzo( a)pyrene (BaP) and pyrene (P). Benzo(a)pyrene 146-161 prohibitin 2 Rattus norvegicus 175-178 14691214-2 2004 Benzo[a]pyrene (BaP), a prototypical polycyclic aromatic hydrocarbon (PAH), can be bioactivated by cytochrome P-450s (CYPs) and epoxide hydrolase to genotoxic metabolites which form covalent adducts with DNA. Benzo(a)pyrene 0-14 prohibitin 2 Rattus norvegicus 16-19 12401509-1 2002 The objective of this study was to evaluate the effect of subacute exposure to inhaled benzo(a)pyrene (BaP) on fetal survival and luteal maintenance using timed-pregnant Fisher 344 rats. Benzo(a)pyrene 87-101 prohibitin 2 Rattus norvegicus 103-106 12151640-1 2002 Intracellular Ca2+ oscillations induced by oxytocin and vasopressin were analyzed in a rat liver cell line (Clone 9) in order to identify mechanisms by which benzo[a]pyrene (BaP) alters Ca2+ signaling patterns in these cells. Benzo(a)pyrene 158-172 prohibitin 2 Rattus norvegicus 174-177 10880142-2 2000 The focus of this article is a molecular evaluation of the neurotoxicological effects that result subsequent to the transplacental exposure of fetal rats to desorbed benzo(a)pyrene (BaP) following maternal inhalation. Benzo(a)pyrene 166-180 prohibitin 2 Rattus norvegicus 182-185 12052463-2 2002 Benzo(a)pyrene (BaP) and 7,12-dimethylbenz(a)anthracene (DMBA) are polycyclic aromatic hydrocarbons (PAHs) found in the tar fraction of cigarette smoke, as well as in car exhaust and furnace gases. Benzo(a)pyrene 0-14 prohibitin 2 Rattus norvegicus 16-19 10037326-5 1999 Benzo[a]pyrene (BaP) yielded similar mutation profiles as its ultimate mutagen BPDE, if 100-fold increased doses were applied. Benzo(a)pyrene 0-14 prohibitin 2 Rattus norvegicus 16-19 9852999-1 1998 Benzo(a)pyrene (BaP) and related aromatic hydrocarbons are suspected carcinogens; however, the molecular basis underlying tumorigenesis remains unclear. Benzo(a)pyrene 0-14 prohibitin 2 Rattus norvegicus 16-19 7767909-9 1995 DR increased benzo[a]pyrene (BaP) metabolic activation in both young and aged rats. Benzo(a)pyrene 13-27 prohibitin 2 Rattus norvegicus 29-32 20654422-1 1998 In the present study, the time- and concentration-dependent effects of the carcinogen benzo[a]pyrene (BaP) on c-fos, c-jun, c-myc and c-Ha-ras expression were evaluated in primary cultured rat hepatocytes. Benzo(a)pyrene 86-100 prohibitin 2 Rattus norvegicus 102-105 9048959-2 1997 The partial decrease in cytochrome P-450 content indicated altered levels of the P-450 isozymes, which may have profound effects on the metabolic disposition of benzo[a]pyrene [BaP]. Benzo(a)pyrene 161-175 prohibitin 2 Rattus norvegicus 177-180 8806728-1 1996 Polycyclic aromatic hydrocarbons, such as benzo(a)pyrene (BaP), have been implicated in the initiation and progression of vascular lesions of atherosclerotic morphology in laboratory animals. Benzo(a)pyrene 42-56 prohibitin 2 Rattus norvegicus 58-61 8806846-1 1996 The detailed urinary excretion profiles of 1-hydroxypyrene (1-OHP) and benzo(a)pyrene (BaP) metabolites were studied following acute intravenous administration of pyrene and BaP, respectively, or after injection of the metabolites themselves. Benzo(a)pyrene 71-85 prohibitin 2 Rattus norvegicus 87-90 9167065-1 1996 The association of small quantities of ferric oxide with Benzo[a]Pyrene (BaP) appears to increase in vivo the toxic effect of BaP. Benzo(a)pyrene 57-71 prohibitin 2 Rattus norvegicus 73-76 9167065-1 1996 The association of small quantities of ferric oxide with Benzo[a]Pyrene (BaP) appears to increase in vivo the toxic effect of BaP. Benzo(a)pyrene 57-71 prohibitin 2 Rattus norvegicus 126-129 2342494-1 1990 The mutagenic activation of benzo[a]pyrene (BaP) after exposure to aorta smooth muscle cells of different origin was examined. Benzo(a)pyrene 28-42 prohibitin 2 Rattus norvegicus 44-47 8239995-1 1993 A high performance liquid chromatographic technique coupled with fluorometric detection was used to study the disappearance rate of the hemoglobin and albumin adducts of benzo(a)pyrene (BaP) in female Sprague-Dawley rats. Benzo(a)pyrene 170-184 prohibitin 2 Rattus norvegicus 186-189