PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34875574-11	2022	FM IL-1beta secretion was inhibited by allopurinol, which blocks uric acid production, for LPS and PGN, and to a lesser degree, MDP.	Allopurinol	39-50	interleukin 1 alpha	Homo sapiens	3-11	
1325990-5	1992	IL-1 released during reoxygenation was newly synthesized, and its production was triggered by the generation of oxygen free radicals, as it could be blocked by the addition of either allopurinol or free radical scavengers to cultures and could be stimulated in part by low concentrations of hydrogen peroxide or xanthine/xanthine oxidase.	Allopurinol	183-194	interleukin 1 alpha	Homo sapiens	0-4	
31705795-0	2020	Allopurinol inhibits excess glucose-induced trophoblast IL-1beta and ROS production.	Allopurinol	0-11	interleukin 1 alpha	Homo sapiens	56-64	
33456597-9	2020	Addition of synbiotic to allopurinol leads to a blood uric acid lowering (18.7% vs. 13.3%, p <0.01), CRP reduction (75% vs. 26.3%, p <0.01) as well as decrease of cytokines level: IL-1beta, IL-6, IL-8, IL-10 and TNFalpha (all p <0.001).	Allopurinol	25-36	interleukin 1 alpha	Homo sapiens	180-188	
31705795-6	2020	Under excess glucose conditions, allopurinol significantly inhibited trophoblast secretion of inflammatory IL-1beta; caspase-1 activity; IL-8; RANTES; and GRO-alpha.	Allopurinol	33-44	interleukin 1 alpha	Homo sapiens	107-115	
31705795-10	2020	Together, our findings indicate that the xanthine oxidase inhibitor allopurinol inhibited excess glucose-induced trophoblast IL-1beta secretion.	Allopurinol	68-79	interleukin 1 alpha	Homo sapiens	125-133	
31705795-11	2020	Additionally, through its inhibition of both IL-1beta and ROS production by the trophoblast, allopurinol reduced the additional pro-inflammatory and anti-angiogenic responses to excess glucose.	Allopurinol	93-104	interleukin 1 alpha	Homo sapiens	45-53	
24758886-8	2014	Recently, reports for four trials described the efficacy of canakinumab and rilonacept, two IL-1 inhibitors, for preventing flares during the initiation of allopurinol therapy.	Allopurinol	156-167	interleukin 1 alpha	Homo sapiens	92-96	
29245201-8	2018	Postoperative levels of IL1-ss and IL-6 were lower in the allopurinol group.	Allopurinol	58-69	interleukin 1 alpha	Homo sapiens	24-27