PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33372687-0 2020 Diallyl trisulfide regulates cell apoptosis and invasion in human Osteosarcoma U2OS cells through regulating PI3K/AKT/GSK3beta signaling pathway. diallyl trisulfide 0-18 AKT serine/threonine kinase 1 Homo sapiens 114-117 33751676-0 2021 Diallyl trisulphide, a H2 S donor, compromises the stem cell phenotype and restores thyroid-specific gene expression in anaplastic thyroid carcinoma cells by targeting AKT-SOX2 axis. diallyl trisulfide 0-19 AKT serine/threonine kinase 1 Homo sapiens 168-171 28344324-0 2017 Diallyl trisulfide suppresses tumor growth through the attenuation of Nrf2/Akt and activation of p38/JNK and potentiates cisplatin efficacy in gastric cancer treatment. diallyl trisulfide 0-18 AKT serine/threonine kinase 1 Homo sapiens 75-78 27035545-0 2016 Diallyl trisulfide induces osteosarcoma cell apoptosis through reactive oxygen species-mediated downregulation of the PI3K/Akt pathway. diallyl trisulfide 0-18 AKT serine/threonine kinase 1 Homo sapiens 123-126 28344324-9 2017 We showed that treatment of BGC-823 cells with DATS in vitro and in vivo significantly activated kinases such as p38 and JNK/MAPK and attenuated the Nrf2/Akt pathway. diallyl trisulfide 47-51 AKT serine/threonine kinase 1 Homo sapiens 154-157 28216514-9 2017 In cultured human umbilical vein endothelium cells, DATS decreased apoptotic activity and oxidative stress under hypoxic conditions, and stimulated the phosphorylation of Akt and eNOS. diallyl trisulfide 52-56 AKT serine/threonine kinase 1 Homo sapiens 171-174 27035545-6 2016 DATS induced apoptosis in the MG63 and MNNG/HOS cells via inhibition of the PI3K/Akt signaling pathway and through the mitochondrial apoptotic pathway. diallyl trisulfide 0-4 AKT serine/threonine kinase 1 Homo sapiens 81-84 27035545-8 2016 However, N-acetylcysteine (NAC), a general ROS scavenger, completely blocked the DATS-induced ROS increase, inhibition of the PI3K/Akt pathway and cell apoptosis. diallyl trisulfide 81-85 AKT serine/threonine kinase 1 Homo sapiens 131-134 24309133-0 2014 Diallyl trisulfide-induced apoptosis of bladder cancer cells is caspase-dependent and regulated by PI3K/Akt and JNK pathways. diallyl trisulfide 0-18 AKT serine/threonine kinase 1 Homo sapiens 104-107 24309133-9 2014 The study further investigated the roles of the phosphatidylinositol 3-kinase (PI3K)/Akt and mitogen-activated protein kinases (MAPKs) pathways with respect to the apoptotic effect of DATS, and showed that DATS deactivates Akt. diallyl trisulfide 184-188 AKT serine/threonine kinase 1 Homo sapiens 85-88 24309133-11 2014 Unlike ERK, JNK inhibitors reversed DATS-induced apoptosis and growth inhibition; however, inhibition of PI3K/Akt notably enhanced the apoptotic action of DATS. diallyl trisulfide 155-159 AKT serine/threonine kinase 1 Homo sapiens 110-113 19748259-0 2010 Diallyl trisulfide induces Bcl-2 and caspase-3-dependent apoptosis via downregulation of Akt phosphorylation in human T24 bladder cancer cells. diallyl trisulfide 0-18 AKT serine/threonine kinase 1 Homo sapiens 89-92 19748259-4 2010 Mechanistically, DATS inhibits phosphatidylinositol 3"-kinase/Akt activation that, in turn, results in modulation of Bcl-2 family proteins, leading to enhanced apoptosis of T24 cells. diallyl trisulfide 17-21 AKT serine/threonine kinase 1 Homo sapiens 62-65 16169930-0 2006 Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells. diallyl trisulfide 0-18 AKT serine/threonine kinase 1 Homo sapiens 67-70 16169930-3 2006 Here, we demonstrate that DATS inactivates Akt to trigger apoptosis in prostate cancer cells. diallyl trisulfide 26-30 AKT serine/threonine kinase 1 Homo sapiens 43-46 16169930-4 2006 Treatment of PC-3/DU145 cells with apoptosis inducing concentration of DATS (40 microM) resulted in a rapid decrease in Ser(473) and Thr(308) phosphorylation of Akt leading to inhibition of its kinase activity. diallyl trisulfide 71-75 AKT serine/threonine kinase 1 Homo sapiens 161-164 16169930-6 2006 DATS treatment (40 microM) also caused a decrease in Ser(155) and Ser(136) phosphorylation of BAD (a proapoptotic protein), which is a downstream target of Akt. diallyl trisulfide 0-4 AKT serine/threonine kinase 1 Homo sapiens 156-159 16169930-10 2006 Ectopic expression of constitutively active Akt conferred statistically significant protection against DATS-induced apoptosis. diallyl trisulfide 103-107 AKT serine/threonine kinase 1 Homo sapiens 44-47 16169930-12 2006 In conclusion, the present study demonstrates that DATS-induced apoptosis in human prostate cancer cells is mediated, at least in part, by inactivation of Akt signaling axis. diallyl trisulfide 51-55 AKT serine/threonine kinase 1 Homo sapiens 155-158 16965246-0 2006 Diallyl trisulfide inhibits angiogenic features of human umbilical vein endothelial cells by causing Akt inactivation and down-regulation of VEGF and VEGF-R2. diallyl trisulfide 0-18 AKT serine/threonine kinase 1 Homo sapiens 101-104 16965246-1 2006 We have shown recently that diallyl trisulfide (DATS), a cancer-chemopreventive constituent of garlic, inactivates Akt to trigger mitochondrial translocation of proapoptotic protein BAD in human prostate cancer cells. diallyl trisulfide 28-46 AKT serine/threonine kinase 1 Homo sapiens 115-118 16965246-1 2006 We have shown recently that diallyl trisulfide (DATS), a cancer-chemopreventive constituent of garlic, inactivates Akt to trigger mitochondrial translocation of proapoptotic protein BAD in human prostate cancer cells. diallyl trisulfide 48-52 AKT serine/threonine kinase 1 Homo sapiens 115-118 22020565-0 2012 Diallyl trisulfide-induced prostate cancer cell death is associated with Akt/PKB dephosphorylation mediated by P-p66shc. diallyl trisulfide 0-18 AKT serine/threonine kinase 1 Homo sapiens 73-76 22020565-13 2012 In such cells, DATS-induced Akt dephosphorylation was significantly reduced. diallyl trisulfide 15-19 AKT serine/threonine kinase 1 Homo sapiens 28-31 22020565-15 2012 CONCLUSIONS: Our results uncover a novel signaling pathway with p66Shc being indispensable for DATS-induced inactivation of Akt due to hypophosphorylation. diallyl trisulfide 95-99 AKT serine/threonine kinase 1 Homo sapiens 124-127 19823037-7 2009 The results from semi-quantitative and real-time RT-PCR indicated that DATS-enhanced the expression levels of FAS and cyclin D1, but in contrast, downregulated the expression levels of Akt and Bcl-2. diallyl trisulfide 71-75 AKT serine/threonine kinase 1 Homo sapiens 185-188 16965246-7 2006 DATS treatment inhibited the formation of capillary-like tube structure and migration by HUVECs in association with suppression of vascular endothelial growth factor (VEGF) secretion and VEGF receptor-2 protein level and inactivation of Akt kinase. diallyl trisulfide 0-4 AKT serine/threonine kinase 1 Homo sapiens 237-240