PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28753455-7	2017	Moreover, DATS provoked intracellular ROS generation and the loss of mitochondrial membrane potential, and in particular, when ROS production was blocked by antioxidant N-acety-l-cysteine, both AMPK activation and growth inhibition by DATS were completely abolished.	diallyl trisulfide	10-14	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	194-198	
28753455-7	2017	Moreover, DATS provoked intracellular ROS generation and the loss of mitochondrial membrane potential, and in particular, when ROS production was blocked by antioxidant N-acety-l-cysteine, both AMPK activation and growth inhibition by DATS were completely abolished.	diallyl trisulfide	235-239	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	194-198	
28753455-8	2017	Collectively, these findings suggest that DATS inhibited growth of AGS cells, which was mediated by complex interplay between cellular mechanisms governing redox homeostasis, apoptosis, and cell cycle arrest, through a ROS-dependent activation of AMPK pathway.	diallyl trisulfide	42-46	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	247-251	
28753455-0	2017	Diallyl trisulfide induces apoptosis and mitotic arrest in AGS human gastric carcinoma cells through reactive oxygen species-mediated activation of AMP-activated protein kinase.	diallyl trisulfide	0-18	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	148-176	
28753455-3	2017	In this study, we investigated the role of ROS on the activation of AMP-activated protein kinase (AMPK) in DATS-induced apoptosis and cell cycle arrest in AGS human gastric carcinoma cells.	diallyl trisulfide	107-111	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	68-96	
28753455-3	2017	In this study, we investigated the role of ROS on the activation of AMP-activated protein kinase (AMPK) in DATS-induced apoptosis and cell cycle arrest in AGS human gastric carcinoma cells.	diallyl trisulfide	107-111	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	98-102	
28753455-6	2017	Furthermore, we found that DATS concurrently induced phosphorylation of AMPK; however, chemical inhibition of AMPK by compound C, an AMPK inhibitor, significantly blocked apoptosis induced by DATS, suggesting that DATS induces cytotoxicity of AGS cells through the AMPK-dependent pathway.	diallyl trisulfide	27-31	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	72-76	
28753455-6	2017	Furthermore, we found that DATS concurrently induced phosphorylation of AMPK; however, chemical inhibition of AMPK by compound C, an AMPK inhibitor, significantly blocked apoptosis induced by DATS, suggesting that DATS induces cytotoxicity of AGS cells through the AMPK-dependent pathway.	diallyl trisulfide	27-31	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	110-114	
28753455-6	2017	Furthermore, we found that DATS concurrently induced phosphorylation of AMPK; however, chemical inhibition of AMPK by compound C, an AMPK inhibitor, significantly blocked apoptosis induced by DATS, suggesting that DATS induces cytotoxicity of AGS cells through the AMPK-dependent pathway.	diallyl trisulfide	27-31	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	110-114	
28753455-6	2017	Furthermore, we found that DATS concurrently induced phosphorylation of AMPK; however, chemical inhibition of AMPK by compound C, an AMPK inhibitor, significantly blocked apoptosis induced by DATS, suggesting that DATS induces cytotoxicity of AGS cells through the AMPK-dependent pathway.	diallyl trisulfide	27-31	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	110-114	
28753455-6	2017	Furthermore, we found that DATS concurrently induced phosphorylation of AMPK; however, chemical inhibition of AMPK by compound C, an AMPK inhibitor, significantly blocked apoptosis induced by DATS, suggesting that DATS induces cytotoxicity of AGS cells through the AMPK-dependent pathway.	diallyl trisulfide	192-196	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	72-76	
28753455-6	2017	Furthermore, we found that DATS concurrently induced phosphorylation of AMPK; however, chemical inhibition of AMPK by compound C, an AMPK inhibitor, significantly blocked apoptosis induced by DATS, suggesting that DATS induces cytotoxicity of AGS cells through the AMPK-dependent pathway.	diallyl trisulfide	192-196	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	110-114	
28753455-6	2017	Furthermore, we found that DATS concurrently induced phosphorylation of AMPK; however, chemical inhibition of AMPK by compound C, an AMPK inhibitor, significantly blocked apoptosis induced by DATS, suggesting that DATS induces cytotoxicity of AGS cells through the AMPK-dependent pathway.	diallyl trisulfide	192-196	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	110-114	
28753455-6	2017	Furthermore, we found that DATS concurrently induced phosphorylation of AMPK; however, chemical inhibition of AMPK by compound C, an AMPK inhibitor, significantly blocked apoptosis induced by DATS, suggesting that DATS induces cytotoxicity of AGS cells through the AMPK-dependent pathway.	diallyl trisulfide	192-196	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	110-114	
28753455-6	2017	Furthermore, we found that DATS concurrently induced phosphorylation of AMPK; however, chemical inhibition of AMPK by compound C, an AMPK inhibitor, significantly blocked apoptosis induced by DATS, suggesting that DATS induces cytotoxicity of AGS cells through the AMPK-dependent pathway.	diallyl trisulfide	192-196	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	72-76	
28753455-6	2017	Furthermore, we found that DATS concurrently induced phosphorylation of AMPK; however, chemical inhibition of AMPK by compound C, an AMPK inhibitor, significantly blocked apoptosis induced by DATS, suggesting that DATS induces cytotoxicity of AGS cells through the AMPK-dependent pathway.	diallyl trisulfide	192-196	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	110-114	
28753455-6	2017	Furthermore, we found that DATS concurrently induced phosphorylation of AMPK; however, chemical inhibition of AMPK by compound C, an AMPK inhibitor, significantly blocked apoptosis induced by DATS, suggesting that DATS induces cytotoxicity of AGS cells through the AMPK-dependent pathway.	diallyl trisulfide	192-196	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	110-114	
28753455-6	2017	Furthermore, we found that DATS concurrently induced phosphorylation of AMPK; however, chemical inhibition of AMPK by compound C, an AMPK inhibitor, significantly blocked apoptosis induced by DATS, suggesting that DATS induces cytotoxicity of AGS cells through the AMPK-dependent pathway.	diallyl trisulfide	192-196	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	110-114