PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16583357-2	2006	In the bronchi of patients with aspirin-intolerant asthma, we previously linked cys-LT over-production and aspirin hyper-reactivity with elevated immunoexpression in eosinophils of the terminal enzyme for cys-LT production, LTC4 synthase.	Cysteine	205-208	leukotriene C4 synthase	Homo sapiens	224-237	
23378248-3	2013	The inhibition of human LTC4S will make a simple way to treat the cys-LT relevant inflammatory diseases.	Cysteine	66-69	leukotriene C4 synthase	Homo sapiens	24-29	
26283693-13	2015	Novel drugs depleting cys-LT production could be beneficial for treatment of inflammatory diseases associated with overexpression of LTC4S.	Cysteine	22-25	leukotriene C4 synthase	Homo sapiens	133-138	
22848603-8	2012	In human heart biopsies from 14 patients with chronic coronary artery disease mRNA expression levels of LTC(4)S and CysLT1 were increased in chronic ischemic compared to non-ischemic myocardium, constituting a molecular basis for increased cys-LT signaling.	Cysteine	240-243	leukotriene C4 synthase	Homo sapiens	104-111	
15131571-2	2004	LTC(4) synthase is a key enzyme in the cys-LT biosynthetic pathway, and studies in small populations have suggested that a promoter polymorphism (A(-444)C) in the gene might be associated with asthma severity and aspirin intolerance.	Cysteine	39-42	leukotriene C4 synthase	Homo sapiens	0-15	
10400832-5	1999	LTC4 synthase, the terminal enzyme for cys-LT production, is markedly overexpressed in eosinophils and mast cells from bronchial biopsy specimens of most patients with AIA.	Cysteine	39-42	leukotriene C4 synthase	Homo sapiens	0-13	
12360108-0	2002	Leukotriene C4 synthase gene A(-444)C polymorphism and clinical response to a CYS-LT(1) antagonist, pranlukast, in Japanese patients with moderate asthma.	Cysteine	78-81	leukotriene C4 synthase	Homo sapiens	0-23	
12069849-2	2002	The final step in the biosynthesis of LTC(4), the parent compound of cys-LTs, is catalyzed by a specific GSH transferase termed LTC(4) synthase, which is typically expressed in certain bone marrow-derived cells such as eosinophils and mast cells.	Cysteine	69-72	leukotriene C4 synthase	Homo sapiens	128-143	
10970818-2	2000	The gene coding for leukotriene (LT) C(4) synthase (LTC(4)S), the enzyme controlling cys-LT biosynthesis, exists as two common alleles distinguished by an A to C transversion at a site 444 nucleotides upstream of the translation start.	Cysteine	85-88	leukotriene C4 synthase	Homo sapiens	20-50	
10970818-2	2000	The gene coding for leukotriene (LT) C(4) synthase (LTC(4)S), the enzyme controlling cys-LT biosynthesis, exists as two common alleles distinguished by an A to C transversion at a site 444 nucleotides upstream of the translation start.	Cysteine	85-88	leukotriene C4 synthase	Homo sapiens	52-59	
10970818-11	2000	Genetic predisposition to cys-LT pathway upregulation, a hallmark of AIA, can be related to overactive expression of the LTC(4)S (-444)C allele.	Cysteine	26-29	leukotriene C4 synthase	Homo sapiens	121-128	
9466979-3	1998	Counts of cells expressing the terminal enzyme for cys-LT synthesis, LTC4 synthase, were fivefold higher in AIA biopsies (11.5+/-2.2 cells/mm2, n = 10) than in ATA biopsies (2.2+/-0.7, n = 10; P = 0.	Cysteine	51-54	leukotriene C4 synthase	Homo sapiens	69-82	
9466979-7	1998	Enhanced baseline cys-LT levels in bronchoalveolar lavage (BAL) fluid of AIA patients correlated uniquely with bronchial counts of LTC4 synthase+ cells (rho = 0.83, P = 0.01).	Cysteine	18-21	leukotriene C4 synthase	Homo sapiens	131-144	
9466979-11	1998	Aspirin may remove PGE2-dependent suppression in all subjects, but only in AIA patients does increased bronchial expression of LTC4 synthase allow marked overproduction of cys-LTs leading to bronchoconstriction.	Cysteine	172-175	leukotriene C4 synthase	Homo sapiens	127-140