PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9617379-13	1998	Studies involving ranitidine treatment in association with interleukin-2 for renal carcinoma and metastatic melanoma are also of interest although no statistically significant results are available as yet.	Ranitidine	18-28	interleukin 2	Homo sapiens	59-72	
15665623-3	2004	Because antihistamines such as cimetidine and ranitidine are commonly used as prophylaxis against gastrointestinal toxicity commonly seen with IL-2, and, because antihistamines may increase natural killer cell activity, it is reasonable to examine the response rate for this combination.	Ranitidine	46-56	interleukin 2	Homo sapiens	143-147	
8481359-3	1993	Most trials utilizing high dose IL-2 employ indomethacin and ranitidine in order to alleviate or prevent IL-2 toxicity, but only administer these medications concurrently with IL-2 therapy.	Ranitidine	61-71	interleukin 2	Homo sapiens	105-109	
8481359-3	1993	Most trials utilizing high dose IL-2 employ indomethacin and ranitidine in order to alleviate or prevent IL-2 toxicity, but only administer these medications concurrently with IL-2 therapy.	Ranitidine	61-71	interleukin 2	Homo sapiens	105-109	
2023098-5	1991	Spontaneous and in vitro interleukin-2- and interferon-alpha-stimulated natural killer cell activity improved in the ranitidine-treated patients in contrast to a decrease in nontreated patients (#p less than 0.03, #p less than 0.01, #p less than 0.02 between groups, respectively).	Ranitidine	117-127	interleukin 2	Homo sapiens	25-38	
1353559-0	1992	Effect of indomethacin plus ranitidine in advanced melanoma patients on high-dose interleukin-2.	Ranitidine	28-38	interleukin 2	Homo sapiens	82-95	
1353559-5	1992	Indomethacin and ranitidine may be responsible for some responses in melanoma patients previously attributed to IL-2.	Ranitidine	17-27	interleukin 2	Homo sapiens	112-116	
2023098-6	1991	Furthermore, T-cell blastogenesis to phytohemagglutinin stimulation and soluble interleukin-2 receptors in serum increased in ranitidine-treated patients compared with nontreated patients (#p less than 0.01).	Ranitidine	126-136	interleukin 2	Homo sapiens	80-93	
2688344-5	1989	Perioperative ranitidine diminished the expected postoperative reduction in DTH responses (p less than 0.0001), as well as in spontaneous NK-cell activity (p less than 0.03) and in vitro IL-2 stimulated NK-cell activity (p less than 0.02).	Ranitidine	14-24	interleukin 2	Homo sapiens	187-191	
2150668-8	1990	The effect of histamine on NK cell responsiveness to IL-2 was mediated by H2-type histamine receptors, as judged by mimicry exerted by the specific H2 receptor agonist dimaprit, but not by an H2-receptor-inactive derivative of this compound, N-methyldimaprit, and blocking by the H2 receptor antagonist ranitidine.	Ranitidine	303-313	interleukin 2	Homo sapiens	53-57	
17200726-3	2006	According to an earlier report, the postoperative administration of the histamine receptor-2 antagonist ranitidine increases the blood levels of soluble IL2 receptor in humans undergoing abdominal surgery and could thus affect molecular determinants of colonic anastomosis.	Ranitidine	104-114	interleukin 2	Homo sapiens	153-156