PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8063004-4	1994	In vivo administration of cimetidine and ranitidine decreased the contents of P450 isozymes and the activities of P450-linked monooxygenase systems; i.e., benzphetamine N-demethylase, aminopyrine N-demethylase, 7-ethoxycoumarin O-deethylase, debrisoquine 4-hydroxylase and bufuralol 1"-hydroxylase.	Ranitidine	41-51	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	242-268	
8063004-10	1994	The activities of debrisoquine 4-hydroxylase and bufuralol 1"-hydroxylase were inhibited in vitro by cimetidine or ranitidine at a higher concentration than that on in vivo administration of either H2 blocker.	Ranitidine	115-125	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	18-44	
8063004-12	1994	The kinetic parameters for cimetidine or ranitidine as to the activities of debrisoquine 4-hydroxylase and bufuralol 1"-hydroxylase in liver microsomes were determined by means of Lineweaver-Burk plots.	Ranitidine	41-51	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	76-102