PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26784938-2	2016	The goal of this study was to determine the association between metformin"s pharmacokinetics and pharmacodynamics and the genetic variants of MATE1 (rs2289669) and OCT2 (rs316019) before and after treatment with the potential MATE inhibitor, ranitidine.	Ranitidine	242-252	solute carrier family 22 member 2	Homo sapiens	164-168	
29490902-3	2018	The objectives of this study were to use a physiologically based pharmacokinetic modeling platform to 1) assess the impact of alterations in DT expression, toxin-drug interactions (TDIs), and free fraction (fu) on PK predictions for the organic cation transporter 2/multidrug and toxin extrusion protein 1 substrate metformin in RI populations; and 2) use available in vitro data to improve predictions of CLR for two actively secreted substrates, metformin and ranitidine.	Ranitidine	462-472	solute carrier family 22 member 2	Homo sapiens	237-305	
16141367-0	2005	Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3).	Ranitidine	52-62	solute carrier family 22 member 2	Homo sapiens	138-143	
16141367-0	2005	Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3).	Ranitidine	52-62	solute carrier family 22 member 2	Homo sapiens	145-152	
16141367-3	2005	Inhibition and substrate specificity of hOCT1, hOCT2, and hOCT3 for ranitidine and famotidine were elucidated in cRNA-injected Xenopus laevis oocytes.	Ranitidine	68-78	solute carrier family 22 member 2	Homo sapiens	47-52	
16141367-4	2005	Ranitidine and famotidine exhibited similarly potent inhibition of [3H]1-methyl-4-phenyl pyridinium uptake into hOCT1-expressing (IC50= 33 and 28 microM, respectively) and hOCT2-expressing oocytes (IC50= 76 and 114 microM, respectively).	Ranitidine	0-10	solute carrier family 22 member 2	Homo sapiens	172-177	
16141367-6	2005	[3H]Ranitidine uptake was stimulated by hOCT1 (Km= 70 +/- 9 microM) and to a much smaller extent by hOCT2.	Ranitidine	4-14	solute carrier family 22 member 2	Homo sapiens	100-105