PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28709912-2	2017	As ranitidine is a substrate for the efflux transporter P-glycoprotein (P-gp), we hypothesized that the sex-related influence could be due to interactions between PEG 400 and P-gp.	Ranitidine	3-13	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	56-70	
29530563-2	2018	For instance, the commonly-used solubilizing agent polyethylene glycol 400 (PEG 400) exhibits a sex-specific effect on the bioavailability of ranitidine in both humans and rats, mediated by the efflux transporter P-glycoprotein (P-gp).	Ranitidine	142-152	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	213-227	
29530563-2	2018	For instance, the commonly-used solubilizing agent polyethylene glycol 400 (PEG 400) exhibits a sex-specific effect on the bioavailability of ranitidine in both humans and rats, mediated by the efflux transporter P-glycoprotein (P-gp).	Ranitidine	142-152	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	229-233	
29530563-6	2018	In addition, while the P-gp inhibitor CsA increased the intestinal uptake of ranitidine in both male and female rats, a greater extent of intestinal transport modulation was observed in males compared to females.	Ranitidine	77-87	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	23-27	
30118850-1	2018	The aim of this study was to explore the influence of food on P-glycoprotein (P-gp) relative expression in both male and female rats, and its effect on intestinal permeation of P-gp substrates (ranitidine and ganciclovir) and a P-gp non-substrate (metformin).	Ranitidine	194-204	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	78-82	
30118850-1	2018	The aim of this study was to explore the influence of food on P-glycoprotein (P-gp) relative expression in both male and female rats, and its effect on intestinal permeation of P-gp substrates (ranitidine and ganciclovir) and a P-gp non-substrate (metformin).	Ranitidine	194-204	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	177-181	
30118850-1	2018	The aim of this study was to explore the influence of food on P-glycoprotein (P-gp) relative expression in both male and female rats, and its effect on intestinal permeation of P-gp substrates (ranitidine and ganciclovir) and a P-gp non-substrate (metformin).	Ranitidine	194-204	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	177-181	
28709912-2	2017	As ranitidine is a substrate for the efflux transporter P-glycoprotein (P-gp), we hypothesized that the sex-related influence could be due to interactions between PEG 400 and P-gp.	Ranitidine	3-13	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	72-76	
28709912-2	2017	As ranitidine is a substrate for the efflux transporter P-glycoprotein (P-gp), we hypothesized that the sex-related influence could be due to interactions between PEG 400 and P-gp.	Ranitidine	3-13	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	175-179	
28709912-6	2017	Inhibition of P-gp by oral pre-treatment with cyclosporine A increased the bioavailability of the P-gp substrates (ampicillin and ranitidine) in males and females (p<0.05), and to a greater extent in males, but had no influence on the bioavailability of metformin in either male or female rats.	Ranitidine	130-140	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	14-18	
28709912-6	2017	Inhibition of P-gp by oral pre-treatment with cyclosporine A increased the bioavailability of the P-gp substrates (ampicillin and ranitidine) in males and females (p<0.05), and to a greater extent in males, but had no influence on the bioavailability of metformin in either male or female rats.	Ranitidine	130-140	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	98-102	
15909533-12	2005	In addition, the AUC of ranitidine in bile decreased in the treatment of cyclosporine or quinidine, which suggests that the hepatobiliary excretion of ranitidine was partially regulated by P-glycoprotein or organic cation transporter.	Ranitidine	24-34	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	189-203	
15909533-12	2005	In addition, the AUC of ranitidine in bile decreased in the treatment of cyclosporine or quinidine, which suggests that the hepatobiliary excretion of ranitidine was partially regulated by P-glycoprotein or organic cation transporter.	Ranitidine	151-161	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	189-203	
9862768-0	1999	Modulation of the permeability of H2 receptor antagonists cimetidine and ranitidine by P-glycoprotein in rat intestine and the human colonic cell line Caco-2.	Ranitidine	73-83	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	87-101	
9862768-4	1999	Ileal ranitidine secretion was concentration dependent and significantly reduced by the P-glycoprotein (P-gp) substrates verapamil and cyclosporin.	Ranitidine	6-16	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	88-102	
9862768-4	1999	Ileal ranitidine secretion was concentration dependent and significantly reduced by the P-glycoprotein (P-gp) substrates verapamil and cyclosporin.	Ranitidine	6-16	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	104-108	
9862768-8	1999	Caco-2 monolayers, which overexpress P-gp, also showed asymmetric permeability of ranitidine and cimetidine.	Ranitidine	82-92	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	37-41	
9862768-11	1999	These data indicate that ranitidine and cimetidine can act as substrates for intestinal P-gp and suggest that the balance between absorptive and secretory mechanisms as a factor in determining intestinal absorption needs to be a routine consideration even for compounds expected to have a predominantly paracellular route of absorption.	Ranitidine	25-35	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	88-92