PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31638830-3 2019 We previously demonstrated that cyclooxygenase-2 (COX-2) and the prostaglandin E receptor, prostanoid E receptor subtype 1, are involved in seizure-mediated P-gp up-regulation. Prostaglandins E 65-80 ATP binding cassette subfamily B member 1 Homo sapiens 157-161 20206383-4 2010 Furthermore, down regulation of MDR1 upon COX-2 knockdown by siRNA showed a decrease in the PKC levels and activation of PKC by addition of PGE(2) to K562 cells, suggesting a role for PKC in the COX-2 mediated induction of MDR1. Prostaglandins E 140-143 ATP binding cassette subfamily B member 1 Homo sapiens 32-36 21801152-6 2011 The induction of MDR1 expression by PGE(2), a metabolite of COX-2, and its downregulation by COX-2 knockdown or CA implies that the enhanced sensitivity of HepG2 cells to doxorubicin by CA is mediated by the downregulation of MDR1 expression, via COX-2-dependent mechanism. Prostaglandins E 36-39 ATP binding cassette subfamily B member 1 Homo sapiens 17-21 15501994-11 2005 In conclusion, the cyclooxygenase system, especially the cyclooxygenase-2 isoform, might be involved in regulating doxorubicin-induced MDR1 overexpression in AML cells, with PGE(2) seeming to be a mediating factor. Prostaglandins E 174-177 ATP binding cassette subfamily B member 1 Homo sapiens 135-139