PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31638830-3	2019	We previously demonstrated that cyclooxygenase-2 (COX-2) and the prostaglandin E receptor, prostanoid E receptor subtype 1, are involved in seizure-mediated P-gp up-regulation.	Prostaglandins E	65-80	ATP binding cassette subfamily B member 1	Homo sapiens	157-161	
15501994-11	2005	In conclusion, the cyclooxygenase system, especially the cyclooxygenase-2 isoform, might be involved in regulating doxorubicin-induced MDR1 overexpression in AML cells, with PGE(2) seeming to be a mediating factor.	Prostaglandins E	174-177	ATP binding cassette subfamily B member 1	Homo sapiens	135-139	
21801152-6	2011	The induction of MDR1 expression by PGE(2), a metabolite of COX-2, and its downregulation by COX-2 knockdown or CA implies that the enhanced sensitivity of HepG2 cells to doxorubicin by CA is mediated by the downregulation of MDR1 expression, via COX-2-dependent mechanism.	Prostaglandins E	36-39	ATP binding cassette subfamily B member 1	Homo sapiens	17-21	
20206383-4	2010	Furthermore, down regulation of MDR1 upon COX-2 knockdown by siRNA showed a decrease in the PKC levels and activation of PKC by addition of PGE(2) to K562 cells, suggesting a role for PKC in the COX-2 mediated induction of MDR1.	Prostaglandins E	140-143	ATP binding cassette subfamily B member 1	Homo sapiens	32-36