PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19552640-8	2009	In pAMs, IL-4/IL-13 significantly increased eotaxin-2, which was reduced by Mp infection accompanied by dose-dependent PGE(2) induction.	Prostaglandins E	119-122	interleukin 4	Mus musculus	9-13	
19552640-9	2009	Exogenous PGE(2) inhibited IL-4/IL-13-induced eotaxin-2 in a dose-dependent manner.	Prostaglandins E	10-13	interleukin 4	Mus musculus	27-31	
12009531-5	2002	Both, IL-4 but mainly, IL-10 (1 and 10 ng/ml) decreased the TMEV-induced expression of COX-2 as well as the synthesis of PGE(2).	Prostaglandins E	121-124	interleukin 4	Mus musculus	6-10	
16012943-7	2005	Exposure of muscle cells to IL-4 or IL-13 increased TGF-beta1 ( P < .01), COX-2 protein, and prostaglandin (PG)E 2 .	Prostaglandins E	96-115	interleukin 4	Mus musculus	28-32	
12370375-9	2002	Responses to PGE(2) and histamine, which were dependent on mast cells and STAT6, were enhanced by IL-4C, but not by IL-13.	Prostaglandins E	13-16	interleukin 4	Mus musculus	98-103	
12594847-7	2003	Treatment with PGE(1) induced an early increase in IL-4 production by liver NKT cells in normal mice and neutralization of the early IL-4 by administration of anti-IL-4 mAb abolished PGE(1)-induced abrogation of oral tolerance.	Prostaglandins E	15-18	interleukin 4	Mus musculus	51-55	
12594847-7	2003	Treatment with PGE(1) induced an early increase in IL-4 production by liver NKT cells in normal mice and neutralization of the early IL-4 by administration of anti-IL-4 mAb abolished PGE(1)-induced abrogation of oral tolerance.	Prostaglandins E	15-18	interleukin 4	Mus musculus	133-137	
12594847-7	2003	Treatment with PGE(1) induced an early increase in IL-4 production by liver NKT cells in normal mice and neutralization of the early IL-4 by administration of anti-IL-4 mAb abolished PGE(1)-induced abrogation of oral tolerance.	Prostaglandins E	15-18	interleukin 4	Mus musculus	133-137	
12594847-7	2003	Treatment with PGE(1) induced an early increase in IL-4 production by liver NKT cells in normal mice and neutralization of the early IL-4 by administration of anti-IL-4 mAb abolished PGE(1)-induced abrogation of oral tolerance.	Prostaglandins E	183-186	interleukin 4	Mus musculus	133-137	
12594847-7	2003	Treatment with PGE(1) induced an early increase in IL-4 production by liver NKT cells in normal mice and neutralization of the early IL-4 by administration of anti-IL-4 mAb abolished PGE(1)-induced abrogation of oral tolerance.	Prostaglandins E	183-186	interleukin 4	Mus musculus	133-137	
12594847-8	2003	These results suggest that liver NKT cells producing IL-4 are responsible for the down-regulation of oral tolerance that is caused by the PGE molecules.	Prostaglandins E	138-141	interleukin 4	Mus musculus	53-57	
11352769-5	2001	We found that Il4 was able to down-regulate the radiation-induced production of mediators of inflammation such as Gro1 (also known as KC, N51) in plasma and lung, corticosterone in blood, Il1b in lung, and prostaglandin E(2) in colon, suggesting the anti-inflammatory potential of Il4 in regulating the radiation-induced response.	Prostaglandins E	206-221	interleukin 4	Mus musculus	14-17	
7750457-8	1995	Importantly, PGE antagonized the inhibitory effects of both IL-4 and IFN gamma on the osteoclastic cell-forming potential of bone marrow macrophages.	Prostaglandins E	13-16	interleukin 4	Mus musculus	60-64	
10731717-7	2000	Furthermore, the induction of c-fos by arachidonic acid, PGE(2), and cAMP was suppressed by pretreatment with interleukin (IL)-4.	Prostaglandins E	57-60	interleukin 4	Mus musculus	110-128	
10731717-8	2000	We also showed that the tyrosine phosphorylation of a Janus kinase, JAK3, is enhanced by IL-4 treatment, suggesting that the PGE(2)-mediated c-fos mRNA induction is inhibited by IL-4 through the tyrosine phosphorylation of JAK3.	Prostaglandins E	125-128	interleukin 4	Mus musculus	89-93	
10731717-8	2000	We also showed that the tyrosine phosphorylation of a Janus kinase, JAK3, is enhanced by IL-4 treatment, suggesting that the PGE(2)-mediated c-fos mRNA induction is inhibited by IL-4 through the tyrosine phosphorylation of JAK3.	Prostaglandins E	125-128	interleukin 4	Mus musculus	178-182	
8621932-1	1996	While investigating an involvement of other factors aside from endogenous IL-3 and prostaglandin E (PGE) in mast cell induction from mouse splenocytes, we found that the mast cell induction was inversely proportional to IL-4 levels and tended to directly proportionate IFN-gamma levels in the supernatants recovered on days 2 and 4.	Prostaglandins E	100-103	interleukin 4	Mus musculus	220-224	
11086097-5	2000	IgE/Ag-mediated activation of BMMC induced the secretion of IL-4, IL-6, and GM-CSF, and concurrent PGE(2) stimulation synergistically increased mast cell degranulation and IL-6 and GM-CSF, but not IL-4, production.	Prostaglandins E	99-102	interleukin 4	Mus musculus	197-201	
7995935-2	1995	We previously reported that PGE, and other agents that increase intracellular cAMP, synergize with IL-4 and LPS to induce IgE and IgG1 production while inhibiting IgM and IgG3 synthesis.	Prostaglandins E	28-31	interleukin 4	Mus musculus	99-103	
2170523-3	1990	In addition to its effects on IgE and IgG1, PGE also causes a significant decrease in IgM and IgG3 synthesis, suggesting that PGE may promote IL-4-induced class switching.	Prostaglandins E	44-47	interleukin 4	Mus musculus	142-146	
2170523-3	1990	In addition to its effects on IgE and IgG1, PGE also causes a significant decrease in IgM and IgG3 synthesis, suggesting that PGE may promote IL-4-induced class switching.	Prostaglandins E	126-129	interleukin 4	Mus musculus	142-146	
7995935-3	1995	These data suggested that PGE may promote IL-4-induced class switching, but the mechanism by which PGE increases IgE synthesis remained obscure.	Prostaglandins E	26-29	interleukin 4	Mus musculus	42-46	
7995935-6	1995	3) PGE synergizes with IL-4 to induce germline epsilon transcripts, demonstrating that PGE acts at the level of transcription in cells that have not yet switched to IgE.	Prostaglandins E	87-90	interleukin 4	Mus musculus	23-27	
7995935-7	1995	4) In the presence of PGE, rearranged mature V(D)J epsilon mRNA transcripts can be detected earlier and at higher levels than with IL-4 and LPS alone.	Prostaglandins E	22-25	interleukin 4	Mus musculus	131-135	
1328389-11	1992	Although PGE inhibits activation-associated events, we previously reported that PGE enhances IL-4 and LPS-induced differentiation to IgE and IgG1 synthesis.	Prostaglandins E	80-83	interleukin 4	Mus musculus	93-97	
1328389-14	1992	Furthermore, the PGE activation-inhibited subset of B cells was responsive to PGE enhancement of IL-4-induced class switching, reducing IgM synthesis and inducing a sevenfold increase in IgE and IgG1 synthesis compared with other sort groups.	Prostaglandins E	17-20	interleukin 4	Mus musculus	97-101	
1328389-14	1992	Furthermore, the PGE activation-inhibited subset of B cells was responsive to PGE enhancement of IL-4-induced class switching, reducing IgM synthesis and inducing a sevenfold increase in IgE and IgG1 synthesis compared with other sort groups.	Prostaglandins E	78-81	interleukin 4	Mus musculus	97-101