PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11443200-7 2001 These results suggest that induction of PGE(2) by IL-1alpha may be an important component of the PTHrP production of the inflammatory process in synovial tissues from patients with RA. Prostaglandins E 40-43 interleukin 1 alpha Homo sapiens 50-59 11055589-10 2000 CONCLUSIONS: These results show that the inhibition of Col1a1 expression by IL-1 in fibroblasts is mediated by prostaglandins at the transcriptional level and suggest that PGE-responsive factors may interact directly or indirectly with basal regulatory elements in the proximal promoter region of the Col1a1 gene. Prostaglandins E 172-175 interleukin 1 alpha Homo sapiens 76-80 11455120-12 2001 Additionally, we show that this enzyme is under the control of pro-inflammatory cytokines whereby TGFbeta and IL-1 stimulate and PGE(2) inhibits its activity. Prostaglandins E 129-132 interleukin 1 alpha Homo sapiens 110-114 11859379-9 1996 Although IL-1-induced IL-6 expression was only affected when both prostaglandin and leukotriene biosynthesis were inhibited, elevated levels of PGE(2) but not leukotriene B(4), C(4), D(4), or E(4) were observed in the culture medium of IL-1-treated chondrocytes. Prostaglandins E 144-147 interleukin 1 alpha Homo sapiens 9-13 10671814-3 2000 Under a serum-free culture condition, an increase in PGE(2) production by IL-1alpha and IL-1beta was observed at concentrations of 10 and 100 ng/ml compared to control cultures. Prostaglandins E 53-56 interleukin 1 alpha Homo sapiens 74-83 23194965-0 1996 Dose-dependent reversal effects of Capsaicin on Interleukin-1alpha production is associated with the metabolism of arachidonic acid (leukotriene B(4) and prostaglandin E(2)) as well as nitric oxide production in human leukocytes. Prostaglandins E 154-169 interleukin 1 alpha Homo sapiens 48-66 11859379-9 1996 Although IL-1-induced IL-6 expression was only affected when both prostaglandin and leukotriene biosynthesis were inhibited, elevated levels of PGE(2) but not leukotriene B(4), C(4), D(4), or E(4) were observed in the culture medium of IL-1-treated chondrocytes. Prostaglandins E 144-147 interleukin 1 alpha Homo sapiens 236-240 1397536-0 1992 Effect of staurosporine derivatives on IL-1-stimulated prostaglandin E production. Prostaglandins E 55-70 interleukin 1 alpha Homo sapiens 39-43 7559890-0 1995 Interleukin-1-mediated stimulation of prostaglandin E production is without effect on plasminogen activator activity in human granulosa lutein cell cultures. Prostaglandins E 38-53 interleukin 1 alpha Homo sapiens 0-13 7745012-0 1995 Interleukin-1 stimulates prostaglandin E production by human trophoblast cells from first and third trimesters. Prostaglandins E 25-40 interleukin 1 alpha Homo sapiens 0-13 7745012-2 1995 Interleukin-1 (IL-1) is a known mediator of prostaglandin E (PGE) production in various cell types, including endothelial, amniotic, and endometrial cells; however, its role in the regulation of PGE production in the trophoblast cells is yet unknown. Prostaglandins E 44-59 interleukin 1 alpha Homo sapiens 0-13 7745012-2 1995 Interleukin-1 (IL-1) is a known mediator of prostaglandin E (PGE) production in various cell types, including endothelial, amniotic, and endometrial cells; however, its role in the regulation of PGE production in the trophoblast cells is yet unknown. Prostaglandins E 44-59 interleukin 1 alpha Homo sapiens 15-19 7745012-2 1995 Interleukin-1 (IL-1) is a known mediator of prostaglandin E (PGE) production in various cell types, including endothelial, amniotic, and endometrial cells; however, its role in the regulation of PGE production in the trophoblast cells is yet unknown. Prostaglandins E 61-64 interleukin 1 alpha Homo sapiens 0-13 7745012-2 1995 Interleukin-1 (IL-1) is a known mediator of prostaglandin E (PGE) production in various cell types, including endothelial, amniotic, and endometrial cells; however, its role in the regulation of PGE production in the trophoblast cells is yet unknown. Prostaglandins E 61-64 interleukin 1 alpha Homo sapiens 15-19 7745012-2 1995 Interleukin-1 (IL-1) is a known mediator of prostaglandin E (PGE) production in various cell types, including endothelial, amniotic, and endometrial cells; however, its role in the regulation of PGE production in the trophoblast cells is yet unknown. Prostaglandins E 195-198 interleukin 1 alpha Homo sapiens 0-13 7745012-2 1995 Interleukin-1 (IL-1) is a known mediator of prostaglandin E (PGE) production in various cell types, including endothelial, amniotic, and endometrial cells; however, its role in the regulation of PGE production in the trophoblast cells is yet unknown. Prostaglandins E 195-198 interleukin 1 alpha Homo sapiens 15-19 7745012-6 1995 IL-1 induced a 5-fold increase in PGE production, a response that was cell density, time, and dose dependent. Prostaglandins E 34-37 interleukin 1 alpha Homo sapiens 0-4 7745012-7 1995 IL-1-induced PGE biosynthesis was prevented in the presence of either IL-1 receptor antagonist or the soluble IL-1 receptor, suggesting a receptor-mediated response. Prostaglandins E 13-16 interleukin 1 alpha Homo sapiens 0-4 7745012-7 1995 IL-1-induced PGE biosynthesis was prevented in the presence of either IL-1 receptor antagonist or the soluble IL-1 receptor, suggesting a receptor-mediated response. Prostaglandins E 13-16 interleukin 1 alpha Homo sapiens 70-74 7745012-8 1995 Significantly, de novo production of PGE by trophoblast cells in the absence of IL-1 was also markedly (50%) reduced by either the IL-1 receptor antagonist or the soluble IL-1 receptor, further supporting the notion that IL-1 is involved in PGE synthesis even under basal conditions. Prostaglandins E 37-40 interleukin 1 alpha Homo sapiens 131-135 7745012-8 1995 Significantly, de novo production of PGE by trophoblast cells in the absence of IL-1 was also markedly (50%) reduced by either the IL-1 receptor antagonist or the soluble IL-1 receptor, further supporting the notion that IL-1 is involved in PGE synthesis even under basal conditions. Prostaglandins E 37-40 interleukin 1 alpha Homo sapiens 131-135 7745012-8 1995 Significantly, de novo production of PGE by trophoblast cells in the absence of IL-1 was also markedly (50%) reduced by either the IL-1 receptor antagonist or the soluble IL-1 receptor, further supporting the notion that IL-1 is involved in PGE synthesis even under basal conditions. Prostaglandins E 241-244 interleukin 1 alpha Homo sapiens 131-135 7745012-8 1995 Significantly, de novo production of PGE by trophoblast cells in the absence of IL-1 was also markedly (50%) reduced by either the IL-1 receptor antagonist or the soluble IL-1 receptor, further supporting the notion that IL-1 is involved in PGE synthesis even under basal conditions. Prostaglandins E 241-244 interleukin 1 alpha Homo sapiens 131-135 7745012-9 1995 Transforming growth factor-beta 1, a putative modulator of the effects of IL-1, significantly attenuated IL-1-stimulated PGE production, supporting the possibility that transforming growth factor-beta 1 may serve as a regulator of the effects of IL-1 in trophoblast cells. Prostaglandins E 121-124 interleukin 1 alpha Homo sapiens 74-78 7745012-9 1995 Transforming growth factor-beta 1, a putative modulator of the effects of IL-1, significantly attenuated IL-1-stimulated PGE production, supporting the possibility that transforming growth factor-beta 1 may serve as a regulator of the effects of IL-1 in trophoblast cells. Prostaglandins E 121-124 interleukin 1 alpha Homo sapiens 105-109 7745012-9 1995 Transforming growth factor-beta 1, a putative modulator of the effects of IL-1, significantly attenuated IL-1-stimulated PGE production, supporting the possibility that transforming growth factor-beta 1 may serve as a regulator of the effects of IL-1 in trophoblast cells. Prostaglandins E 121-124 interleukin 1 alpha Homo sapiens 105-109 7745012-10 1995 These observations suggest a pivotal role of IL-1 in the regulation of PGE economy by trophoblast cells. Prostaglandins E 71-74 interleukin 1 alpha Homo sapiens 45-49 1809690-3 1991 Endogenously synthesized Il-1 in turn activates PGE release, indicating that the C5b-9 attack initiates an autocrine feedback stimulation. Prostaglandins E 48-51 interleukin 1 alpha Homo sapiens 25-29 18475489-2 1992 As interleukin-1 (IL-1) stimulates keratinocyte PGE synthesis we investigated whether the degree of confluency of the keratinocyte culture modified the response of the cells to IL-1. Prostaglandins E 48-51 interleukin 1 alpha Homo sapiens 3-16 18475489-2 1992 As interleukin-1 (IL-1) stimulates keratinocyte PGE synthesis we investigated whether the degree of confluency of the keratinocyte culture modified the response of the cells to IL-1. Prostaglandins E 48-51 interleukin 1 alpha Homo sapiens 18-22 18475489-3 1992 It was found that IL-1alpha (100 U/ml) stimulated PGE(2) synthesis by proliferating (7 days in culture) but not differentiating (14 days in culture) keratinocytes. Prostaglandins E 50-53 interleukin 1 alpha Homo sapiens 18-27 2297544-3 1990 Increased levels of prostaglandin E were produced in the same experiments, indicating that the cells were responsive to the interleukin 1 preparations. Prostaglandins E 20-35 interleukin 1 alpha Homo sapiens 124-137 2117917-2 1990 It is known that both interleukin-1 alpha (IL-1 alpha) and 12-O-tetradecanoylphorbol 13-acetate (TPA) promote increases in intracellular levels of the glycolytic regulatory metabolite fructose 2,6-bisphosphate [Fru(2,6)P2] and in the production of prostaglandin E (PGE) by subcultured rheumatoid synovial cells (RSC) and human dermal fibroblasts in vitro. Prostaglandins E 248-263 interleukin 1 alpha Homo sapiens 22-41 2117917-2 1990 It is known that both interleukin-1 alpha (IL-1 alpha) and 12-O-tetradecanoylphorbol 13-acetate (TPA) promote increases in intracellular levels of the glycolytic regulatory metabolite fructose 2,6-bisphosphate [Fru(2,6)P2] and in the production of prostaglandin E (PGE) by subcultured rheumatoid synovial cells (RSC) and human dermal fibroblasts in vitro. Prostaglandins E 248-263 interleukin 1 alpha Homo sapiens 43-53 2117917-2 1990 It is known that both interleukin-1 alpha (IL-1 alpha) and 12-O-tetradecanoylphorbol 13-acetate (TPA) promote increases in intracellular levels of the glycolytic regulatory metabolite fructose 2,6-bisphosphate [Fru(2,6)P2] and in the production of prostaglandin E (PGE) by subcultured rheumatoid synovial cells (RSC) and human dermal fibroblasts in vitro. Prostaglandins E 265-268 interleukin 1 alpha Homo sapiens 22-41 2117917-2 1990 It is known that both interleukin-1 alpha (IL-1 alpha) and 12-O-tetradecanoylphorbol 13-acetate (TPA) promote increases in intracellular levels of the glycolytic regulatory metabolite fructose 2,6-bisphosphate [Fru(2,6)P2] and in the production of prostaglandin E (PGE) by subcultured rheumatoid synovial cells (RSC) and human dermal fibroblasts in vitro. Prostaglandins E 265-268 interleukin 1 alpha Homo sapiens 43-53 2117917-3 1990 We report here that the protein kinase C inhibitor staurosporine enhanced the IL-1 alpha-induced increase in [Fru(2,6)P2] and PGE production by RSC, whereas in similar concentrations (3-30 nM) this inhibitor decreased the TPA-induced stimulation of these parameters. Prostaglandins E 126-129 interleukin 1 alpha Homo sapiens 78-88 34737801-10 2021 Vicenin 3 was found to significantly inhibit IL-1beta-induced production of NO and PGE. Prostaglandins E 83-86 interleukin 1 alpha Homo sapiens 45-53 2176076-1 1990 Cultured human periodontal ligament fibroblasts showed synergistic elevations in the synthesis of prostaglandin E and production of cAMP by the administration of parathyroid hormone and cytokines (interleukin 1 alpha, -1 beta, or tumour necrosis factor-alpha). Prostaglandins E 98-113 interleukin 1 alpha Homo sapiens 197-258 2559195-0 1989 Possible involvement of prostaglandin E in development of ACTH response in rats induced by human recombinant interleukin-1. Prostaglandins E 24-39 interleukin 1 alpha Homo sapiens 109-122 35506586-6 2022 The expression of the prostaglandin E synthase Ptges and the production of PGE2 were higher in Orai2-KD astrocytes than in WT astrocytes when stimulated with TNFalpha and IL1alpha. Prostaglandins E 22-37 interleukin 1 alpha Homo sapiens 171-179 2789072-0 1989 Effect of diclofenac on prostaglandin E and hyaluronic acid production by human synovial fibroblasts stimulated with interleukin-1. Prostaglandins E 24-39 interleukin 1 alpha Homo sapiens 117-130 2492458-0 1989 Synergy of interleukin 1 (IL-1) with arachidonic acid and A23187 in stimulating PGE synthesis in human fibroblasts: IL-1 stimulates fibroblast cyclooxygenase. Prostaglandins E 80-83 interleukin 1 alpha Homo sapiens 11-30 2541163-3 1989 We report here on prostaglandin E and its relationship to interleukin 1, tumor necrosis factor, and leukotriene B4 produced by macrophages from blood and cerebrospinal fluid of MS patients and controls in vitro. Prostaglandins E 18-33 interleukin 1 alpha Homo sapiens 58-71 2492458-0 1989 Synergy of interleukin 1 (IL-1) with arachidonic acid and A23187 in stimulating PGE synthesis in human fibroblasts: IL-1 stimulates fibroblast cyclooxygenase. Prostaglandins E 80-83 interleukin 1 alpha Homo sapiens 26-30 2492458-1 1989 The stimulation of prostaglandin E (PGE) synthesis by interleukin 1 (IL-1) has important physiologic effects in many target tissues. Prostaglandins E 19-34 interleukin 1 alpha Homo sapiens 54-73 2492458-1 1989 The stimulation of prostaglandin E (PGE) synthesis by interleukin 1 (IL-1) has important physiologic effects in many target tissues. Prostaglandins E 36-39 interleukin 1 alpha Homo sapiens 54-73 2492458-2 1989 The mechanism(s) whereby IL-1 stimulates PGE synthesis is not well understood. Prostaglandins E 41-44 interleukin 1 alpha Homo sapiens 25-29 2492458-4 1989 We examined these mechanisms in IL-1 stimulation of human dermal fibroblast PGE synthesis. Prostaglandins E 76-79 interleukin 1 alpha Homo sapiens 32-36 2492458-8 1989 For example, the combination of IL-1 and A23187, used at concentrations where neither agent alone stimulated PGE synthesis, increased PGE synthesis from 3.1 to 22.5 ng/ml; similar synergy was seen between IL-1 and exogenous arachidonic acid. Prostaglandins E 109-112 interleukin 1 alpha Homo sapiens 32-36 2492458-8 1989 For example, the combination of IL-1 and A23187, used at concentrations where neither agent alone stimulated PGE synthesis, increased PGE synthesis from 3.1 to 22.5 ng/ml; similar synergy was seen between IL-1 and exogenous arachidonic acid. Prostaglandins E 134-137 interleukin 1 alpha Homo sapiens 32-36 2492458-11 1989 These results suggest that IL-1 increases fibroblast PGE synthesis by a mechanism(s) other than making available increased membrane arachidonic acid, and that at least part of its effect may be mediated by induction of cyclooxygenase. Prostaglandins E 53-56 interleukin 1 alpha Homo sapiens 27-31 2492458-12 1989 Furthermore, the effect of IL-1 on fibroblast PGE synthesis is markedly potentiated by agents which increase available substrate. Prostaglandins E 46-49 interleukin 1 alpha Homo sapiens 27-31 2513997-8 1989 IL-1 is a highly inflammatory molecule and stimulates the production of arachidonic acid metabolites, most consistently, prostaglandin E. Prostaglandins E 121-136 interleukin 1 alpha Homo sapiens 0-4 2484435-4 1989 Other agents that increase intracellular cAMP, such as prostaglandin E (PGE) or isobutyl-methylxanthine (IBMX), also synergized with IL-1 or TNF alpha (but not with FK). Prostaglandins E 55-70 interleukin 1 alpha Homo sapiens 133-137 2484435-4 1989 Other agents that increase intracellular cAMP, such as prostaglandin E (PGE) or isobutyl-methylxanthine (IBMX), also synergized with IL-1 or TNF alpha (but not with FK). Prostaglandins E 72-75 interleukin 1 alpha Homo sapiens 133-137 3098847-4 1987 Conditioned media from stimulated human peripheral blood mononuclear cells; purified human monocyte IL 1, pI 7,6, and 5; and recombinant human IL 1, beta or alpha forms, all changed the secretory pattern of rabbit articular chondrocytes in a similar manner: production and secretion of a latent metalloproteinase(s) and prostaglandin E were stimulated in a concentration-dependent fashion, whereas the activity of plasminogen activator was strongly reduced. Prostaglandins E 320-335 interleukin 1 alpha Homo sapiens 143-147 2512262-5 1989 PGE synthesis was also stimulated by the platelet-derived growth factor (PDGF), interleukin-1 (IL-1), or lipopolysaccharide (LPS). Prostaglandins E 0-3 interleukin 1 alpha Homo sapiens 80-99 2512262-6 1989 The amount of PGE synthesis after incubation with PDGF, LPS and IL-1 was comparable to that released after C5b-9. Prostaglandins E 14-17 interleukin 1 alpha Homo sapiens 64-68 2510238-6 1989 Prostaglandin E production was significantly increased by IL-1 alpha to an extent much greater than that produced by TGF alpha or TGF beta, although the combined addition of IL-1 alpha with either TGF alpha or beta resulted in a synergistic increase in PGE production, a response partly diminished by the addition of IFN-gamma. Prostaglandins E 0-15 interleukin 1 alpha Homo sapiens 58-68 2510238-6 1989 Prostaglandin E production was significantly increased by IL-1 alpha to an extent much greater than that produced by TGF alpha or TGF beta, although the combined addition of IL-1 alpha with either TGF alpha or beta resulted in a synergistic increase in PGE production, a response partly diminished by the addition of IFN-gamma. Prostaglandins E 253-256 interleukin 1 alpha Homo sapiens 174-184 3142218-7 1988 Neither clone produced prostaglandin E (PGE), leukotriene B4 (LTB4), or tumor necrosis factor (TNF) but IL1 alpha production by 1.3 could be influenced by exogenous PGE and TNF. Prostaglandins E 165-168 interleukin 1 alpha Homo sapiens 104-113 3128273-3 1988 Prostaglandin E production was stimulated predominantly by IL1 alpha and IL1 beta rather than by IFN-gamma or TNF alpha. Prostaglandins E 0-15 interleukin 1 alpha Homo sapiens 59-68 3122755-1 1988 The addition of either recombinant human interleukin 1 (IL1 alpha) or 12-O-tetradecanoyl phorbol-13-acetate (TPA) to cultured rheumatoid synovial cells (RSC) caused dose-related increases in PGE production and cellular fructose 2,6-bisphosphate (Fru-2,6-P2). Prostaglandins E 191-194 interleukin 1 alpha Homo sapiens 41-65 3122755-3 1988 A close association between increases in PGE production and Fru-2,6-P2 was demonstrated for both IL1- and TPA-stimulated cells. Prostaglandins E 41-44 interleukin 1 alpha Homo sapiens 97-100 3322024-6 1987 Because many of the actions of IL-1 are mediated by the induction of prostanoid prostaglandin (PG) synthesis, the authors determined the effects of purified macrophage and mesangial IL-1 on the secretion of prostaglandin E (PGE), prostacyclin, and thromboxane. Prostaglandins E 207-222 interleukin 1 alpha Homo sapiens 31-35 3322024-6 1987 Because many of the actions of IL-1 are mediated by the induction of prostanoid prostaglandin (PG) synthesis, the authors determined the effects of purified macrophage and mesangial IL-1 on the secretion of prostaglandin E (PGE), prostacyclin, and thromboxane. Prostaglandins E 207-222 interleukin 1 alpha Homo sapiens 182-186 3322024-7 1987 The results indicated that cycling MCs release primarily PGE in response to purified IL-1. Prostaglandins E 57-60 interleukin 1 alpha Homo sapiens 85-89 3322024-8 1987 The local release by either monocytes or mesangial cells of IL-1 during glomerular inflammation, with subsequent mesangial cell generation of vasodilatory PGE, may be responsible in part for the alterations in the glomerular microcirculation observed in these disorders. Prostaglandins E 155-158 interleukin 1 alpha Homo sapiens 60-64 2961462-0 1987 The activation of human fibroblast prostaglandin E production by interleukin 1. Prostaglandins E 35-50 interleukin 1 alpha Homo sapiens 65-78 2828770-4 1987 We show here that reagents which raise cAMP concentrations (Prostaglandin E, cholera toxin, forskolin) synergize strongly with IL-1 and IL-2 in the generation of antibody. Prostaglandins E 60-75 interleukin 1 alpha Homo sapiens 127-131 3495574-5 1987 In addition, TNF interacted in a synergistic fashion with both IL 1 peptides to augment fibroblast PGE elaboration further. Prostaglandins E 99-102 interleukin 1 alpha Homo sapiens 63-67 6610426-2 1984 Since one of the monocyte products, interleukin-1 (IL-1), has been shown to stimulate the release of collagenase and prostaglandin E from synoviocytes, we have investigated whether IL-1 is also responsible for chondrocyte activation. Prostaglandins E 117-132 interleukin 1 alpha Homo sapiens 36-55 3873493-6 1985 Thus, the effect of IL 1 on monocyte-mediated cytotoxicity is presumably mediated by PGE. Prostaglandins E 85-88 interleukin 1 alpha Homo sapiens 20-24 6610426-2 1984 Since one of the monocyte products, interleukin-1 (IL-1), has been shown to stimulate the release of collagenase and prostaglandin E from synoviocytes, we have investigated whether IL-1 is also responsible for chondrocyte activation. Prostaglandins E 117-132 interleukin 1 alpha Homo sapiens 51-55 6610426-3 1984 Purified preparations of IL-1 derived from human blood monocytes stimulated the production of prostaglandin E and plasminogen activator by human articular chondrocytes. Prostaglandins E 94-109 interleukin 1 alpha Homo sapiens 25-29 24316253-5 2014 In the case of TNF-alpha, IL-1ss and PGE(2) a decreased level of secretion was observed 154 rhog/ml, 736.1 rhog/ml, and 151 rhog/ml respectively when compared with lipopolysaccharide treated cells, where the level of these cytokines was significantly high. Prostaglandins E 37-40 interleukin 1 alpha Homo sapiens 26-30 19688109-4 2009 Leptin alone or in combination with IL-1 enhanced the expression of iNOS and COX-2, and production of NO, PGE(2), IL-6, and IL-8. Prostaglandins E 106-109 interleukin 1 alpha Homo sapiens 36-40 22089456-5 2012 RESULTS: GS treatment at 1 and 2 mM significantly inhibited (p <= 0.03) production of endogenous and IL-1ss-induced PGE(2). Prostaglandins E 119-122 interleukin 1 alpha Homo sapiens 104-108 21682897-16 2011 In addition, the COX-2 product 15DeltaPGJ(2) added to the cells: 1) strongly represses IL-6 and IL-8 induced by IL-1alpha; 2) represses mPGES expression induced by IL-1alpha and the synthesis of PGE(2). Prostaglandins E 137-140 interleukin 1 alpha Homo sapiens 112-121 21682897-16 2011 In addition, the COX-2 product 15DeltaPGJ(2) added to the cells: 1) strongly represses IL-6 and IL-8 induced by IL-1alpha; 2) represses mPGES expression induced by IL-1alpha and the synthesis of PGE(2). Prostaglandins E 137-140 interleukin 1 alpha Homo sapiens 164-173 19245983-8 2009 Morphine and bupivacaine both inhibited the expected rise in NO and PGE(2) when interleukin-1 was added to the media. Prostaglandins E 68-71 interleukin 1 alpha Homo sapiens 80-93 22763855-3 2012 We find that carcinoma cell-derived interleukin-1 (IL-1) induces prostaglandin E(2) (PGE(2)) secretion by MSCs. Prostaglandins E 85-88 interleukin 1 alpha Homo sapiens 36-49 22763855-3 2012 We find that carcinoma cell-derived interleukin-1 (IL-1) induces prostaglandin E(2) (PGE(2)) secretion by MSCs. Prostaglandins E 85-88 interleukin 1 alpha Homo sapiens 51-55 21835205-7 2011 PGE(2) alone showed slight effect on IL-1, IL-18, and IL-33 mRNA expression in DCs. Prostaglandins E 0-3 interleukin 1 alpha Homo sapiens 37-41 19210337-4 2009 In the present study, we investigated whether interleukin-1alpha induced vascular endothelial growth factor production in human periodontal ligament cells and whether cyclooxygenase-2-derived prostaglandin E(2) regulated interleukin-1alpha-induced vascular endothelial growth factor production. Prostaglandins E 192-207 interleukin 1 alpha Homo sapiens 221-239 18302264-10 2008 Exogenous HA significantly and dose-dependently decreased expression of proinflammatory cytokine mRNAs and COX-2/PGE(2) production in IL-1-stimulated SSF. Prostaglandins E 113-116 interleukin 1 alpha Homo sapiens 134-138 18479189-7 2008 A stable knockdown of GPx2 in HT-29 cells by siRNA resulted in a high basal and IL-1-induced expression of COX-2 and mPGES-1, enzymes required for the production of the pro-inflammatory PGE(2). Prostaglandins E 118-121 interleukin 1 alpha Homo sapiens 80-84 18040817-6 2006 IL-1 signaling is required for the production of amygdala PGE(2) in response to surgical stress, and may thus affect the physiological and psychological aspects of surgical stress. Prostaglandins E 58-61 interleukin 1 alpha Homo sapiens 0-4 17371964-2 2007 In the present study, we demonstrate that PGE(2) induced the expression of IL-1alpha in colon cancer cells, which plays critical roles in tumor metastasis and neoangiogenesis in a variety of cancers. Prostaglandins E 42-45 interleukin 1 alpha Homo sapiens 75-84 17371964-3 2007 PGE(2) increased the levels of both IL-1alpha mRNA and protein, suggesting a positive feedback loop between the IL-1 pathway and PGE(2) signaling. Prostaglandins E 0-3 interleukin 1 alpha Homo sapiens 36-45 17371964-3 2007 PGE(2) increased the levels of both IL-1alpha mRNA and protein, suggesting a positive feedback loop between the IL-1 pathway and PGE(2) signaling. Prostaglandins E 0-3 interleukin 1 alpha Homo sapiens 36-40 17371964-3 2007 PGE(2) increased the levels of both IL-1alpha mRNA and protein, suggesting a positive feedback loop between the IL-1 pathway and PGE(2) signaling. Prostaglandins E 129-132 interleukin 1 alpha Homo sapiens 36-45 17371964-3 2007 PGE(2) increased the levels of both IL-1alpha mRNA and protein, suggesting a positive feedback loop between the IL-1 pathway and PGE(2) signaling. Prostaglandins E 129-132 interleukin 1 alpha Homo sapiens 36-40 17371964-4 2007 Mechanistically, PGE(2) induced the expression of IL-1alpha at both transcriptional and posttranscriptional levels. Prostaglandins E 17-20 interleukin 1 alpha Homo sapiens 50-59 17371964-8 2007 Thus, our results suggest that PGE(2) induces the expression of proinflammatory cytokine IL-1alpha, which may potentially enhance the proneoplastic actions of the cyclooxygenase-2/PGE(2) signaling pathway. Prostaglandins E 31-34 interleukin 1 alpha Homo sapiens 89-98 17371964-8 2007 Thus, our results suggest that PGE(2) induces the expression of proinflammatory cytokine IL-1alpha, which may potentially enhance the proneoplastic actions of the cyclooxygenase-2/PGE(2) signaling pathway. Prostaglandins E 180-183 interleukin 1 alpha Homo sapiens 89-98 17251521-1 2007 Interleukin-1alpha(IL-1alpha) stimulates the production of prostaglandin E(2) (PGE(2)) in odontogenic keratocyst fibroblasts. Prostaglandins E 79-82 interleukin 1 alpha Homo sapiens 0-18 17251521-1 2007 Interleukin-1alpha(IL-1alpha) stimulates the production of prostaglandin E(2) (PGE(2)) in odontogenic keratocyst fibroblasts. Prostaglandins E 79-82 interleukin 1 alpha Homo sapiens 19-28 16423868-4 2006 PGE(2) and PGF(2alpha) stimulate expression of IL-1alpha, -1beta, and -6, findings consistent with PG involvement in IL signaling within the seminiferous tubule. Prostaglandins E 0-3 interleukin 1 alpha Homo sapiens 47-72 16297161-8 2005 Endogenous PGE(2) further enhanced IL-1alpha-induced OPG production in HGF. Prostaglandins E 11-14 interleukin 1 alpha Homo sapiens 35-44 17173569-6 2006 RESULTS: Human fibroblasts respond to UVR or to IL-1 by increasing the production of various inflammatory mediators including PGE-2, IL-1, and IL-6 and proteases such as collagenase (MMP-1). Prostaglandins E 126-129 interleukin 1 alpha Homo sapiens 48-52 17173569-7 2006 Treatment of fibroblasts with 10 microm of CoQ10 suppressed the UVR- or IL-1-induced increase in PGE-2, IL-6, and MMP-1. Prostaglandins E 97-100 interleukin 1 alpha Homo sapiens 72-76 15246970-9 2004 IL-1 also stimulated PGE(2) production in gastric fibroblasts via COX-2 induction. Prostaglandins E 21-24 interleukin 1 alpha Homo sapiens 0-4 15246970-10 2004 NS-398 significantly suppressed VEGF and PGE(2) release from IL-1-stimulated gastric fibroblasts; concurrent addition of PGE(2) restored NS-398-inhibited VEGF release. Prostaglandins E 41-44 interleukin 1 alpha Homo sapiens 61-65 12509619-6 2003 RESULTS: A77 1726 inhibited the production of PGE(2) in synoviocytes activated by TNF-alpha and IL-1alpha with median inhibitory concentrations (IC(50)) of 7 and 3 microM respectively. Prostaglandins E 46-49 interleukin 1 alpha Homo sapiens 96-105 12445497-1 2002 This study was designed to investigate the effect of IL-1alpha-induced up-regulation of cyclooxygenase-2 (COX-2) on prostaglandin E(2) (PGE(2)) secretion and the subsequent phenotypic effects of PGE(2) on epithelial cells. Prostaglandins E 116-131 interleukin 1 alpha Homo sapiens 53-62 12445497-1 2002 This study was designed to investigate the effect of IL-1alpha-induced up-regulation of cyclooxygenase-2 (COX-2) on prostaglandin E(2) (PGE(2)) secretion and the subsequent phenotypic effects of PGE(2) on epithelial cells. Prostaglandins E 136-139 interleukin 1 alpha Homo sapiens 53-62 12445497-1 2002 This study was designed to investigate the effect of IL-1alpha-induced up-regulation of cyclooxygenase-2 (COX-2) on prostaglandin E(2) (PGE(2)) secretion and the subsequent phenotypic effects of PGE(2) on epithelial cells. Prostaglandins E 195-198 interleukin 1 alpha Homo sapiens 53-62 12445497-5 2002 Co-treatment of the cells with IL-1alpha and IL-1RA or the COX-2 enzyme inhibitor NS398 abolished the IL-1alpha mediated secretion of PGE(2). Prostaglandins E 134-137 interleukin 1 alpha Homo sapiens 31-40 12445497-5 2002 Co-treatment of the cells with IL-1alpha and IL-1RA or the COX-2 enzyme inhibitor NS398 abolished the IL-1alpha mediated secretion of PGE(2). Prostaglandins E 134-137 interleukin 1 alpha Homo sapiens 102-111 11953974-10 2002 Although IL-1alpha alone did not significantly increase PGE(2) production, significant PGE(2) superinduction occurred in cartilage stimulated with IL-1alpha and the NOS2 inhibitor 1400W compared with stimulation with IL-1alpha alone in hypoxia, but not in normoxia. Prostaglandins E 87-90 interleukin 1 alpha Homo sapiens 147-156 11953974-10 2002 Although IL-1alpha alone did not significantly increase PGE(2) production, significant PGE(2) superinduction occurred in cartilage stimulated with IL-1alpha and the NOS2 inhibitor 1400W compared with stimulation with IL-1alpha alone in hypoxia, but not in normoxia. Prostaglandins E 87-90 interleukin 1 alpha Homo sapiens 147-156