PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27473187-0 2017 CYP2R1 polymorphisms are important modulators of circulating 25-hydroxyvitamin D levels in elderly females with vitamin insufficiency, but not of the response to vitamin D supplementation. 25-hydroxyvitamin D 61-80 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 0-6 6274485-5 1981 The authors hypothesize that the reduction in 1,25-dihydroxyvitamin D, recently reported in postmenopausal osteoporotic women, might be responsible for the increased serum levels of 25-hydroxyvitamin D through an inadequate product inhibition of liver vitamin D 25-hydroxylase. 25-hydroxyvitamin D 182-201 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 252-276 33109689-3 2021 METHODS: We genotyped 116 335 randomly chosen white Danes aged 20 to 100 from the Copenhagen City Heart Study and Copenhagen General Population Study for plasma 25-hydroxyvitamin D decreasing genetic variants around CYP2R1 (rs117913124, rs12794714 and rs10741657), DHCR7 (rs7944926 and rs11234027), GEMIN2 (rs2277458) and HAL (rs3819817). 25-hydroxyvitamin D 161-180 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 216-222 31841498-0 2019 Genetic variation in GC and CYP2R1 affects 25-hydroxyvitamin D concentration and skeletal parameters: A genome-wide association study in 24-month-old Finnish children. 25-hydroxyvitamin D 43-62 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 28-34 28757204-4 2017 Meta-analysis of the summary statistics from 19 cohorts identified in CYP2R1 the low-frequency (minor allele frequency = 2.5%) synonymous coding variant g.14900931G>A (p.Asp120Asp) (rs117913124[A]), which conferred a large effect on 25-hydroxyvitamin D (25OHD) levels (-0.43 SD of standardized natural log-transformed 25OHD per A allele; p value = 1.5 x 10-88). 25-hydroxyvitamin D 236-255 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 70-76 15128933-7 2004 These data identify CYP2R1 as a biologically relevant vitamin D 25-hydroxylase and reveal the molecular basis of a human genetic disease, selective 25-hydroxyvitamin D deficiency. 25-hydroxyvitamin D 148-167 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 20-26 15128933-7 2004 These data identify CYP2R1 as a biologically relevant vitamin D 25-hydroxylase and reveal the molecular basis of a human genetic disease, selective 25-hydroxyvitamin D deficiency. 25-hydroxyvitamin D 148-167 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 54-78 34944511-2 2021 Cytochrome P450 2R1 (CYP2R1) encoded by the CYP2R1 gene is the major hydroxylase that activates vitamin D by catalyzing the formation of 25-hydroxyvitamin D (25(OH)D). 25-hydroxyvitamin D 137-156 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 0-19 34944511-2 2021 Cytochrome P450 2R1 (CYP2R1) encoded by the CYP2R1 gene is the major hydroxylase that activates vitamin D by catalyzing the formation of 25-hydroxyvitamin D (25(OH)D). 25-hydroxyvitamin D 137-156 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 21-27 34944511-2 2021 Cytochrome P450 2R1 (CYP2R1) encoded by the CYP2R1 gene is the major hydroxylase that activates vitamin D by catalyzing the formation of 25-hydroxyvitamin D (25(OH)D). 25-hydroxyvitamin D 137-156 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 44-50 29343764-2 2018 Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). 25-hydroxyvitamin D 23-42 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 128-134 27473561-1 2017 CYP2R1 is the principal hepatic 25-hydroxylase responsible for the hydroxylation of parent vitamin D to 25-hydroxyvitamin D [25(OH)D]. 25-hydroxyvitamin D 104-123 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 0-6 27473187-1 2017 We studied the association between CYP2R1 genetic polymorphisms and circulating 25-hydroxyvitamin D [25(OH)D] before and after supplementation with vitamin D3 in 218 elderly. 25-hydroxyvitamin D 80-99 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 35-41 25003556-0 2014 Triangular relationship between single nucleotide polymorphisms in the CYP2R1 gene (rs10741657 and rs12794714), 25-hydroxyvitamin d levels, and coronary artery disease incidence. 25-hydroxyvitamin D 112-131 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 71-77 26383826-2 2015 The aim of this study was to identify the relationship between 25-hydroxyvitamin D [25-(OH) VD] status and the nonsynonymous single-nucleotide polymorphisms (SNPs) (rs7041 and rs4588) of the GC gene, which encodes the vitamin D binding protein, and one SNP (rs10741657) near the CYP2R1 gene. 25-hydroxyvitamin D 63-82 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 279-285 25527766-0 2015 Common variants in CYP2R1 and GC genes are both determinants of serum 25-hydroxyvitamin D concentrations after UVB irradiation and after consumption of vitamin D3-fortified bread and milk during winter in Denmark. 25-hydroxyvitamin D 70-89 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 19-25 25942481-0 2015 CYP2R1 Mutations Impair Generation of 25-hydroxyvitamin D and Cause an Atypical Form of Vitamin D Deficiency. 25-hydroxyvitamin D 38-57 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 0-6 25942481-5 2015 MAIN OUTCOME MEASURES: Function of mutant CYP2R1 genes as assessed in vivo by serum 25-hydroxyvitamin D values after administration of vitamin D and in vitro by analysis of mutant forms of the CYP2R1. 25-hydroxyvitamin D 84-103 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 42-48 25248651-5 2015 Patients with hypogonadism have frequently low levels of 25-hydroxyvitamin D due to impairment of the hydroxylating enzyme CYP2R1 in the testis. 25-hydroxyvitamin D 57-76 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 123-129 25406188-8 2014 Each increase in DHCR7/CYP2R1 allele score was associated with a 1.9 nmol/L lower plasma 25-hydroxyvitamin D concentration and with increased all cause, cancer, and other mortality but not with cardiovascular mortality. 25-hydroxyvitamin D 89-108 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 23-29 25070320-0 2014 Genetic variants in CYP2R1, CYP24A1, and VDR modify the efficacy of vitamin D3 supplementation for increasing serum 25-hydroxyvitamin D levels in a randomized controlled trial. 25-hydroxyvitamin D 116-135 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 20-26 24596595-1 2014 Genome-wide association studies (GWAS) have identified common polymorphisms in or near GC, CYP2R1, CYP24A1, and NADSYN1/DHCR7 genes to be associated with circulating levels of 25-hydroxyvitamin D [25(OH)D] in European populations. 25-hydroxyvitamin D 176-195 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 91-97 18511070-2 2008 CYP2R1 catalyzes the initial step converting vitamin D into 25-hydroxyvitamin D. 25-hydroxyvitamin D 60-79 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 0-6 24200978-1 2014 Previous studies have identified several common genetic variants in VDR, GC and CYP2R1 to be associated with circulating levels of 25-hydroxyvitamin D [25(OH)D] and vitamin D deficiency in Western populations. 25-hydroxyvitamin D 131-150 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 80-86 22576297-1 2012 UNLABELLED: Recently, genome-wide studies identified genetic variants that affect serum 25-hydroxyvitamin D levels in healthy populations (rs12785878, near dehydrocholesterol reductase, DHCR7; rs10741657, at CYP2R1; and rs7041, at vitamin D binding protein, GC). 25-hydroxyvitamin D 88-107 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 208-214 23063903-1 2012 CYP2R1 (25alpha-hydroxylase) catalyzes vitamin D(3) to 25-hydroxyvitamin D(3), while the CYP27B1 (1alpha-hydroxylase) catalyzes the 25(OH)D(3) to 1, 25(OH)(2)D(3). 25-hydroxyvitamin D 55-74 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 0-6 23734184-3 2013 METHODOLOGY/PRINCIPAL FINDINGS: Associations between CYP2R1, GC, and DHCR7 genotypes that are determinants of reduced 25-hydroxyvitamin D (25[OH]D3) serum levels and the risk of HCV-related HCC development were investigated for 1279 chronic hepatitis C patients with HCC and 4325 without HCC, respectively. 25-hydroxyvitamin D 118-137 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 53-59 23190755-0 2013 Vitamin D intake and season modify the effects of the GC and CYP2R1 genes on 25-hydroxyvitamin D concentrations. 25-hydroxyvitamin D 77-96 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 61-67 21972121-1 2012 Recent studies have identified common variants in or near GC, CYP2R1 and NADSYN1/DHCR7 to be associated with 25-hydroxyvitamin D [25(OH)D] levels in European populations. 25-hydroxyvitamin D 109-128 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 62-68