PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3339589-1	1988	(S)-alpha-Chlorohydrin and 3-chloro-1-hydroxyacetone inhibited the oxidative metabolism of fructose by boar spermatozoa only after a period of incubation in which they presumably underwent conversion to (S)-3-chlorolactaldehyde, an inhibitor of sperm glyceraldehyde 3-phosphate dehydrogenase.	alpha-Chlorohydrin	0-22	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	251-291	
629780-26	1978	An unknown metabolic product of alpha-chlorohydrin is suggested to inhibit glyceraldehyde 3-phosphate dehydrogenase and triose phosphate isomerase of spermatozoa.	alpha-Chlorohydrin	32-50	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	75-115	
7471740-3	1980	Low levels of alpha-chlorohydrin increased the cellular concentrations of fructose-1,6-bisphosphate and the triosephosphates, an effect consistent with the inhibition of glyceraldehyde-3-phosphate dehydrogenase.	alpha-Chlorohydrin	14-32	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	170-210	
3593119-1	1986	When boar spermatozoa were incubated with the (S)-isomer of the male antifertility agent alpha-chlorohydrin the activity of glyceraldehyde-3-phosphate dehydrogenase was inhibited.	alpha-Chlorohydrin	89-107	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	124-164	
4020765-4	1985	When glycerol and (S)-alpha-chlorohydrin were added concomitantly to boar spermatozoa in vitro, the presence of glycerol decreased the degree of inhibition of glyceraldehyde 3-phosphate dehydrogenase.	alpha-Chlorohydrin	18-40	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	159-199	
4020765-5	1985	Extracts of glyceraldehyde 3-phosphate dehydrogenase that were obtained from boar spermatozoa incubated with (S)-alpha-chlorohydrin or (R,S)-3-chlorolactaldehyde showed significant reductions in their enzymic activity.	alpha-Chlorohydrin	109-131	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	12-52	
6861971-2	1983	The presence of glycerol decreases the activity of this enzyme towards (S)-alpha-chlorohydrin in vitro thereby preventing the formation of (S)-3-chlorolactaldehyde, an inhibitor of glyceraldehyde 3-phosphate dehydrogenase in boar sperm.	alpha-Chlorohydrin	71-93	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	181-221	
563260-0	1977	Antifertility mode of action of alpha-chlorohydrin--interaction with glyceraldehyde-3-phosphate-dehydrogenase [proceedings].	alpha-Chlorohydrin	32-50	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	69-109	
11399799-0	2001	alpha-Chlorohydrin inhibits glyceraldehyde-3-phosphate dehydrogenase in multiple organs as well as in sperm.	alpha-Chlorohydrin	0-18	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	28-68	
11399799-1	2001	Numerous studies have documented inhibitory effects of alpha-chlorohydrin (ACH) on glyceraldehyde-3-phosphate dehydrogenase (G3PDH) activity in spermatozoa.	alpha-Chlorohydrin	55-73	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	83-123	
11399799-1	2001	Numerous studies have documented inhibitory effects of alpha-chlorohydrin (ACH) on glyceraldehyde-3-phosphate dehydrogenase (G3PDH) activity in spermatozoa.	alpha-Chlorohydrin	55-73	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	125-130	
11399799-1	2001	Numerous studies have documented inhibitory effects of alpha-chlorohydrin (ACH) on glyceraldehyde-3-phosphate dehydrogenase (G3PDH) activity in spermatozoa.	alpha-Chlorohydrin	75-78	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	83-123	
11399799-1	2001	Numerous studies have documented inhibitory effects of alpha-chlorohydrin (ACH) on glyceraldehyde-3-phosphate dehydrogenase (G3PDH) activity in spermatozoa.	alpha-Chlorohydrin	75-78	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	125-130	
11399799-3	2001	The possibility that ACH may inhibit G3PDH in cell types other than sperm was investigated in this work.	alpha-Chlorohydrin	21-24	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	37-42	
11399799-7	2001	Three h after ACH administration (50 mg/kg po), G3PDH activity was significantly decreased in sperm (85%) as well as in kidney (31%), liver (49%), and epididymis (35%).	alpha-Chlorohydrin	14-17	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	48-53	
11399799-14	2001	Moreover, ACH inhibition of G3PDH is not confined to sperm, although the sperm enzyme is most sensitive to inhibition.	alpha-Chlorohydrin	10-13	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	28-33	
8848575-2	1995	The high phosphatase activity hydrolyses the ester to alpha-chlorohydrin which undergoes oxidation to (S)-3-chlorolactaldehyde, a specific inhibitor of sperm glyceraldehyde-3-phosphate dehydrogenase and triosephosphate isomerase, thereby exhibiting an anti-glycolytic action.	alpha-Chlorohydrin	54-72	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	158-198