PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18063462-3	2008	We sought to further explore the neurotoxic effects of 3-MCPD (10 or 30 mg/kg) administered for 13 weeks on the expression of two forms of nitric oxide synthase (NOS), neuronal NOS (nNOS), and inducible NOS (iNOS), in rat cerebral cortex and striatum.	alpha-Chlorohydrin	55-61	nitric oxide synthase 2	Rattus norvegicus	193-206	
18063462-3	2008	We sought to further explore the neurotoxic effects of 3-MCPD (10 or 30 mg/kg) administered for 13 weeks on the expression of two forms of nitric oxide synthase (NOS), neuronal NOS (nNOS), and inducible NOS (iNOS), in rat cerebral cortex and striatum.	alpha-Chlorohydrin	55-61	nitric oxide synthase 2	Rattus norvegicus	208-212	
18063462-8	2008	In contrast, iNOS expression was significantly increased in the neocortex and striatum at all three rostrocaudal levels following subchronic 3-MCPD administration.	alpha-Chlorohydrin	141-147	nitric oxide synthase 2	Rattus norvegicus	13-17	
18063462-9	2008	These data suggest that subchronic 3-MCPD exposure may involve compensatory mechanisms acting on nNOS and iNOS expression to maintain nitric oxide homeostasis in the rostral part of the neocortex and striatum.	alpha-Chlorohydrin	35-41	nitric oxide synthase 2	Rattus norvegicus	106-110	
18063462-11	2008	Thus, the present study suggests that 3-MCPD-induced neurotoxicity is mediated, at least in part, through disturbances in the nitric oxide signaling pathway and exhibits a rostrocaudal difference, through differential expression of nNOS and iNOS in the neocortex and striatum.	alpha-Chlorohydrin	38-44	nitric oxide synthase 2	Rattus norvegicus	241-245