PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33380403-7 2020 In na?ve RAW264.7 cells, treatment with both ICG-001 and LPS, as compared with LPS alone, significant promoted TNF-alpha and IL-6 secretions, increased intracellular levels of TNF-alpha, IL-6 and iNOS (P < 0.05), and reduced intracellular FKN, Wnt-4 and beta-catenin levels (P < 0.01). Indocyanine Green 45-48 catenin (cadherin associated protein), beta 1 Mus musculus 254-266 29481294-7 2018 However, for both assays, significant differences were eliminated in the presence of the beta-catenin inhibitor ICG-001. Indocyanine Green 112-115 catenin (cadherin associated protein), beta 1 Mus musculus 89-101 29363326-8 2018 Treatment with a beta-catenin inhibitor (ICG-001) in mice with AdTGF-beta-induced peritoneal fibrosis resulted in attenuation of peritoneal angiogenesis and reduced vascular endothelial growth factor. Indocyanine Green 41-44 catenin (cadherin associated protein), beta 1 Mus musculus 17-29 29758552-11 2018 Moreover, the expression of S100A4 decreased after ICG-001 inhibited beta-catenin signal pathway. Indocyanine Green 51-54 catenin (cadherin associated protein), beta 1 Mus musculus 69-81 28893318-2 2017 Given its ability to inhibit Wnt/beta-catenin signaling pathway, ICG-001 has been used in some tumor types to exert its anticarcinogenic effect. Indocyanine Green 65-68 catenin (cadherin associated protein), beta 1 Mus musculus 33-45 28893318-8 2017 RESULTS: In this study, we showed that ICG-001 significantly inhibited growth and metastasis of multiple GC cell lines, induced cell apoptosis, and augmented in vitro tumor spheres suppression when used in combination with chemotherapy drugs probably through robustly blocking association of beta-catenin with CBP and N-cadherin, but promoting association of beta-catenin with P300 and E-cadherin, instead of altering the distribution and expression of beta-catenin. Indocyanine Green 39-42 catenin (cadherin associated protein), beta 1 Mus musculus 292-304 28893318-8 2017 RESULTS: In this study, we showed that ICG-001 significantly inhibited growth and metastasis of multiple GC cell lines, induced cell apoptosis, and augmented in vitro tumor spheres suppression when used in combination with chemotherapy drugs probably through robustly blocking association of beta-catenin with CBP and N-cadherin, but promoting association of beta-catenin with P300 and E-cadherin, instead of altering the distribution and expression of beta-catenin. Indocyanine Green 39-42 catenin (cadherin associated protein), beta 1 Mus musculus 359-371 28893318-8 2017 RESULTS: In this study, we showed that ICG-001 significantly inhibited growth and metastasis of multiple GC cell lines, induced cell apoptosis, and augmented in vitro tumor spheres suppression when used in combination with chemotherapy drugs probably through robustly blocking association of beta-catenin with CBP and N-cadherin, but promoting association of beta-catenin with P300 and E-cadherin, instead of altering the distribution and expression of beta-catenin. Indocyanine Green 39-42 catenin (cadherin associated protein), beta 1 Mus musculus 359-371 28302627-9 2017 Moreover, beta-catenin inhibitors PKF118-310 and ICG-001 limited growth of mouse and human vascular SMCs in a dose-dependent manner. Indocyanine Green 49-52 catenin (cadherin associated protein), beta 1 Mus musculus 10-22 27624805-7 2017 Treatment with either XAV-939 or ICG-001 effectively inhibited activation of beta-catenin and downregulated mRNA expression of beta-catenin-targeted genes in TDI-asthmatic mice, paralleled by dramatically attenuated TDI-induced hyperresponsiveness and inflammation of the airway, alleviated airway goblet cell metaplasia and collagen deposition, decreased Th2 inflammation, as well as lower levels of TGFbeta1, VEGF, HMGB1, and IL-1beta. Indocyanine Green 33-36 catenin (cadherin associated protein), beta 1 Mus musculus 77-89 27624805-7 2017 Treatment with either XAV-939 or ICG-001 effectively inhibited activation of beta-catenin and downregulated mRNA expression of beta-catenin-targeted genes in TDI-asthmatic mice, paralleled by dramatically attenuated TDI-induced hyperresponsiveness and inflammation of the airway, alleviated airway goblet cell metaplasia and collagen deposition, decreased Th2 inflammation, as well as lower levels of TGFbeta1, VEGF, HMGB1, and IL-1beta. Indocyanine Green 33-36 catenin (cadherin associated protein), beta 1 Mus musculus 127-139 28405131-0 2017 Indocyanine Green-001 (ICG-001) Attenuates Wnt/beta-catenin-induces Myocardial Injury Following Sepsis. Indocyanine Green 0-17 catenin (cadherin associated protein), beta 1 Mus musculus 47-59 28405131-0 2017 Indocyanine Green-001 (ICG-001) Attenuates Wnt/beta-catenin-induces Myocardial Injury Following Sepsis. Indocyanine Green 23-26 catenin (cadherin associated protein), beta 1 Mus musculus 47-59 28405131-1 2017 OBJECTIVE: To investigate the mechanistic pathway of both indocyanine green (ICG)-001 in attenuated endotoxemia-induced cardiac depression through downregulation cardiac Wnt/ beta-catenin cell signaling. Indocyanine Green 58-75 catenin (cadherin associated protein), beta 1 Mus musculus 175-187 28405131-1 2017 OBJECTIVE: To investigate the mechanistic pathway of both indocyanine green (ICG)-001 in attenuated endotoxemia-induced cardiac depression through downregulation cardiac Wnt/ beta-catenin cell signaling. Indocyanine Green 77-80 catenin (cadherin associated protein), beta 1 Mus musculus 175-187 28405131-10 2017 CONCLUSION: Taken together, these data showed that ICG-001 improved LV function following sepsis through downregulation of Wnt/beta-catenin and serve as a potential mechanistic pathway ICG-001 in therapeutic cardiac endotoxemia in animal model. Indocyanine Green 51-54 catenin (cadherin associated protein), beta 1 Mus musculus 127-139 27629364-4 2016 KEY RESULTS: ICG-001, a small-molecule compound that inhibits the beta-catenin/CREB-binding protein (CBP) interaction, strongly and dose-dependently inhibited serum-induced smooth muscle growth and TGFbeta1-induced production of extracellular matrix components in vitro. Indocyanine Green 13-16 catenin (cadherin associated protein), beta 1 Mus musculus 66-78 27629364-7 2016 However, beta-catenin target gene expression was highly increased in response to ovalbumin; this effect was prevented by topical treatment with ICG-001. Indocyanine Green 144-147 catenin (cadherin associated protein), beta 1 Mus musculus 9-21 26957367-9 2016 We further demonstrated that migration of ALCs was inhibited in vitro and that E-cadherin expression was significantly up-regulated when ALCs were treated with the beta-catenin inhibitor, ICG-001. Indocyanine Green 188-191 catenin (cadherin associated protein), beta 1 Mus musculus 164-176 26453613-8 2016 Conversely, blockade of Wnt/beta-catenin by small molecule inhibitor ICG-001 at this point hindered AKI to CKD progression. Indocyanine Green 69-72 catenin (cadherin associated protein), beta 1 Mus musculus 28-40 25012166-8 2015 ICG-001 inhibited renal expression of multiple RAS genes in vivo and abolished the expression of other Wnt/beta-catenin target genes. Indocyanine Green 0-3 catenin (cadherin associated protein), beta 1 Mus musculus 107-119 23316072-6 2013 Activation of beta-catenin/p300-dependent gene expression using the compound ICG-001 accelerated epithelial repair in vitro and in murine models. Indocyanine Green 77-80 catenin (cadherin associated protein), beta 1 Mus musculus 14-26 23203799-7 2013 Both F-TrCP-Ecad and ICG-001 blocked TGF-beta1-induced Smad3/beta-catenin and Smad reporter activity in C1.1 cells, suggesting that TGF-beta1-induced EMT depends on beta-catenin binding to Smad3, but not LEF-1 downstream of Smad3, through canonical Wnt. Indocyanine Green 21-24 catenin (cadherin associated protein), beta 1 Mus musculus 61-73 23203799-10 2013 Inhibition of beta-catenin by either F-TrCP-Ecad or ICG-001 abolished LiCl-induced TOP-flash, but not TGF-beta1-induced Smad reporter, activity in J774 cells. Indocyanine Green 52-55 catenin (cadherin associated protein), beta 1 Mus musculus 14-26 23308088-5 2012 FGFR activation-induced cell proliferation and survival were also inhibited by the compound ICG-001, a small molecule inhibitor of beta-catenin-CREB Binding Protein (CBP) in hepatoblasts, further indicating a CBP-dependent regulatory mechanism of beta-catenin activity. Indocyanine Green 92-95 catenin (cadherin associated protein), beta 1 Mus musculus 131-143 20660310-6 2010 We report here that ICG-001 (5 mg/kg per day) significantly inhibits beta-catenin signaling and attenuates bleomycin-induced lung fibrosis in mice, while concurrently preserving the epithelium. Indocyanine Green 20-23 catenin (cadherin associated protein), beta 1 Mus musculus 69-81 15314234-3 2004 We identified ICG-001, a small molecule that down-regulates beta-catenin/T cell factor signaling by specifically binding to cyclic AMP response element-binding protein. Indocyanine Green 14-17 catenin (cadherin associated protein), beta 1 Mus musculus 60-72