PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32850381-10 2020 These findings provide support for inhibiting CYP24A1 as a potential approach to activate the vitamin D pathway in the prevention and therapy of ovarian cancer. Vitamin D 94-103 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 46-53 6608994-5 1984 Both normal and Hyp mice responded to the vitamin D-deficient diet with a fall in serum calcium (p less than 0.01), significantly increased renal 1-OHase, and significantly decreased renal 24-OHase activities. Vitamin D 42-51 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 189-197 31877961-7 2019 On molecular level, the WD reduced proliferation (p < 0.05) and increased expression of the vitamin D catabolizing enzyme Cyp24a1 (p < 0.001). Vitamin D 92-101 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 122-129 31629064-0 2020 Mechanistic homeostasis of vitamin D metabolism in the kidney through reciprocal modulation of Cyp27b1 and Cyp24a1 expression. Vitamin D 27-36 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 107-114 30553931-1 2019 Calcitroic acid, the excretory form of vitamin D, is the terminal product of a 5-step pathway catalyzed by CYP24A1, commencing with C24-hydroxylation of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3). Vitamin D 39-48 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 107-114 30833469-8 2019 Moreover, fasting upregulated the vitamin D catabolizing CYP24A1 in the kidney through the PGC-1alpha-ERRalpha pathway. Vitamin D 34-43 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 57-64 29710028-4 2018 The protein expressions of markers linked with the vitamin D action were altered by VDD (vitamin D receptor VDR, 25-hydroxyvitamin D-24-hydroxylase CYP24A1, CYP27B1, and CYP2R1). Vitamin D 51-60 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 148-155 29371756-4 2018 In fact, plasma 1,25-dihydroxyvitamin D levels showed a significant correlation with vitamin D metabolism gene Cyp27b1 and Cyp24a1 mRNA expression in the high phosphate group. Vitamin D 30-39 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 123-130 29771914-2 2018 Vitamin D is first modified in the liver by the 25-hydroxylases CYP2R1 and CYP27A1 and further activated in the kidney by the 1alpha-hydroxylase CYP27B1, while the renal 24-hydroxylase CYP24A1 catalyzes the first step of its inactivation. Vitamin D 0-9 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 185-192 28130182-8 2017 Treatment of BEC with 10muM cholecalciferol led to increases in both CYP24A1 and CFTR mRNA levels, even when added to the apical surface of cells grown in an air-liquid interface, suggesting that topical administration of vitamin D could be used therapeutically. Vitamin D 222-231 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 69-76 28492801-7 2017 Calcitriol highly induced its target gene, CYP24A1, indicating that the genomic vitamin D pathway is active in tumorgrafts. Vitamin D 80-89 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 43-50 28093352-6 2017 Disruption of CYP24A1 in mice results in elevated circulating 1,25-(OH)2D, substantiating the importance of the enzyme in the maintenance of vitamin D metabolism. Vitamin D 141-150 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 14-21 20144713-0 2010 CYP24A1-deficient mice as a tool to uncover a biological activity for vitamin D metabolites hydroxylated at position 24. Vitamin D 70-79 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 0-7 27106018-9 2016 CONCLUSIONS: We show for the first time that progestins and vitamin D synergistically reduce cell viability and induce apoptosis in ovarian cells and that progestins PR-dependently inhibit CAL-induced CYP24A1, thus extending CAL activity. Vitamin D 60-69 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 201-208 26784541-1 2016 CYP24A1 (hereafter referred to as CYP24) enzymatic activity is pivotal in the inactivation of vitamin D metabolites. Vitamin D 94-103 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 0-7 26784541-1 2016 CYP24A1 (hereafter referred to as CYP24) enzymatic activity is pivotal in the inactivation of vitamin D metabolites. Vitamin D 94-103 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 0-5 26238339-2 2016 We hypothesised that cells overexpressing CYP24A1 have growth advantage and a diet rich in vitamin D and soy would restore sensitivity to the anti-tumourigenic effects of vitamin D. Vitamin D 171-180 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 42-49 22739976-4 2012 The FGF23-dependent increase in Cyp24a1 mRNA expression in the mouse kidneys was consistent with the possibility that FGF23 induces vitamin D catabolism. Vitamin D 132-141 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 32-39 26704532-4 2016 The 25-hydroxylation involves mainly CYP2R1 and CYP27A1, whereas 1alpha-hydroxylation and 24-hydroxylation are catalyzed by CYP27B1 and CYP24A1, respectively, and are tightly regulated to maintain adequate levels of the active vitamin D hormone, 1alpha,25(OH)2D3. Vitamin D 227-236 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 136-143 26784540-3 2016 In this issue of the JCI, Bai and colleagues demonstrate that deletion or inhibition of CYP24A1, which initiates degradation of the active form of vitamin D, ameliorates skeletal abnormalities in two mouse models of hypophosphatemic rickets. Vitamin D 147-156 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 88-95 24280059-6 2014 As well as stimulating VDR expression, 25(OH)D and 1,25(OH)(2)D dose-dependently increased expression of the classic vitamin D target cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1), demonstrating the presence of an autoregulatory vitamin D-endocrine system in these cells. Vitamin D 117-126 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 134-188 24280059-6 2014 As well as stimulating VDR expression, 25(OH)D and 1,25(OH)(2)D dose-dependently increased expression of the classic vitamin D target cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1), demonstrating the presence of an autoregulatory vitamin D-endocrine system in these cells. Vitamin D 117-126 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 190-197 24280059-6 2014 As well as stimulating VDR expression, 25(OH)D and 1,25(OH)(2)D dose-dependently increased expression of the classic vitamin D target cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1), demonstrating the presence of an autoregulatory vitamin D-endocrine system in these cells. Vitamin D 248-257 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 134-188 24280059-6 2014 As well as stimulating VDR expression, 25(OH)D and 1,25(OH)(2)D dose-dependently increased expression of the classic vitamin D target cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1), demonstrating the presence of an autoregulatory vitamin D-endocrine system in these cells. Vitamin D 248-257 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 190-197 22740316-8 2013 The downregulated 24-hydroxylase (Cyp24a1) gene expression in femoral bone indicated local vitamin D resistance in the mice treated with ZK191784. Vitamin D 91-100 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 34-41 22179019-1 2012 CYP24A1 functions in vitamin D target tissues to degrade 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)). Vitamin D 21-30 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 0-7 20144713-8 2010 These results show that Cyp24a1 deficiency delays fracture repair and strongly suggest that vitamin D metabolites hydroxylated at position 24, such as 24,25(OH)2D3, play an important role in the mechanisms leading to normal fracture healing. Vitamin D 92-101 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 24-31 19920212-8 2010 We identified novel ACTH-induced changes in 1) genes involved in vitamin D (Cyp27b1, Cyp24a1, Gc) and calcium (Sgk, Calb1, Trpv5) metabolism associated with calciuria and phosphaturia; 2) genes that would be predicted to desensitize the kidney to glucocorticoid action (Nr3c1, Hsd11b1, Fkbp5); and 3) genes encoding transporters of enzyme systems associated with xenobiotic metabolism and oxidative stress. Vitamin D 65-74 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 85-92 12421875-5 2002 Levels are determined by skin exposure to ultraviolet light or, to a minor extent, nutritional uptake and by subsequent conversion of the precursor vitamin D to the active hormone by the cytochrome P450 hydroxylases CYP27A1, CYP27B1 (responsible for synthesis) and CYP24 (responsible for catabolism) in liver and kidney. Vitamin D 148-157 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 265-270 19667171-5 2009 RESULTS: In a mouse model fed low (0.04%) nutritional calcium, expression of the vitamin D catabolizing CYP24A1, of the synthesizing CYP27B1 hydroxylase and of the vitamin D receptor was induced in the right colon only. Vitamin D 81-90 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 104-111 18981260-4 2009 PXR strongly represses vitamin D(3) activation of the CYP24A1 gene, in which PXR indirectly binds to and prevents vitamin D(3)-dependent dissociation of SMRT from the CYP24A1 promoter. Vitamin D 114-123 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 167-174 18981260-7 2009 Thus, our present study defines the novel molecular mechanism by which PXR and CAR mediate drug interactions with vitamin D(3) to regulate the CYP24A1 gene. Vitamin D 114-123 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 143-150 17286279-7 2007 These data conclusively demonstrate that VDR mediates the anti-proliferative and pro-apoptotic effects of vitamin D metabolites and analogs, but that the potency of a vitamin D compound to induce the VDR target gene CYP24 does not accurately predict its potency in mediating growth regulation. Vitamin D 167-176 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 216-221 17280828-8 2007 In addition, calcitriol induced the Vitamin D metabolizing enzyme, 24-hydroxylase (cyp24) mRNA and enzyme activity similarly in naive and VDI cells as measured by RT-PCR and HPLC, respectively. Vitamin D 36-45 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 83-88 17237620-10 2006 CYP24 is a key enzyme involved in the breakdown of vitamin D. Vitamin D 51-60 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 0-5 15498883-10 2005 These results suggest that the absence of CYP24A1 or VDR retards catabolism of 1alpha,25(OH)2D3 and 25(OH)D3, reinforcing the physiological importance of CYP24A1 in vitamin D homeostasis. Vitamin D 165-174 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 154-161 18981260-2 2009 In the absence of vitamin D(3), PXR activates the CYP24A1 gene by directly binding to and transactivating vitamin D-response elements (VDREs) within its promoter. Vitamin D 106-115 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 50-57 18981260-3 2009 Vitamin D(3) activates the CYP24A1 promoter by dissociating the corepressor silencing mediator for retinoid and thyroid hormone receptors (SMRT) from the vitamin D receptor (VDR) on those VDREs. Vitamin D 0-9 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 27-34 18981260-4 2009 PXR strongly represses vitamin D(3) activation of the CYP24A1 gene, in which PXR indirectly binds to and prevents vitamin D(3)-dependent dissociation of SMRT from the CYP24A1 promoter. Vitamin D 23-32 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 54-61 18981260-4 2009 PXR strongly represses vitamin D(3) activation of the CYP24A1 gene, in which PXR indirectly binds to and prevents vitamin D(3)-dependent dissociation of SMRT from the CYP24A1 promoter. Vitamin D 23-32 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 167-174 18981260-4 2009 PXR strongly represses vitamin D(3) activation of the CYP24A1 gene, in which PXR indirectly binds to and prevents vitamin D(3)-dependent dissociation of SMRT from the CYP24A1 promoter. Vitamin D 114-123 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 54-61 15225763-0 2004 Insights into Vitamin D metabolism using cyp24 over-expression and knockout systems in conjunction with liquid chromatography/mass spectrometry (LC/MS). Vitamin D 14-23 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 41-46 15225763-7 2004 Similar experiments using the same wild type and CYP24-XO animals and cells and [3H] 1alpha-OH-D2 resulted in the apparent paradox that the Vitamin D prodrug was 25-hydroxylated in vivo but 24-hydroxylated in vitro. Vitamin D 140-149 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 49-54 10875271-1 2000 The 25-hydroxyvitamin D-24-hydroxylase enzyme (24-OHase) is responsible for the catabolic breakdown of 1,25-dihydroxyvitamin D [1,25(OH)2D], the active form of vitamin D. Vitamin D 14-23 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 47-55 10875271-6 2000 Our results confirm the physiological importance of the 24-OHase enzyme for maintaining vitamin D homeostasis, and they reveal that 24,25-dihydroxyvitamin D is a dispensable metabolite during bone development. Vitamin D 88-97 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 56-64