PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32379895-12 2020 Studies examining the effect of vitamin D treatment on serum IGF-1 and IGFBP-3 have not been in agreement since different populations, dosages, and intervention periods have been used. Vitamin D 32-41 insulin like growth factor 1 Homo sapiens 61-66 35626902-2 2022 There is some controversy concerning a potential interaction between vitamin D and PTH and the GH/IGF-1 axis. Vitamin D 69-78 insulin like growth factor 1 Homo sapiens 98-103 33338606-0 2021 Double-counting of effect sizes and inappropriate exclusion of studies in "The influence of vitamin D supplementation on IGF-1 levels in humans: A systematic review and meta-analysis". Vitamin D 92-101 insulin like growth factor 1 Homo sapiens 121-126 34684321-1 2021 Both vitamin D and insulin-like growth factor 1 (IGF-1) play essential roles in bone metabolism and may interact during prepubertal bone accrual. Vitamin D 5-14 insulin like growth factor 1 Homo sapiens 49-54 31375874-2 2019 Vitamin D and calcium supplements increased IGF-1 but did not affect bone mineralization or turnover. Vitamin D 0-9 insulin like growth factor 1 Homo sapiens 44-49 32323557-11 2020 The comparison of serum IGF-1 showed significant difference after 3 days (P = .006) and remained higher in vitamin D group after CPB (P < .001). Vitamin D 107-116 insulin like growth factor 1 Homo sapiens 24-29 32444034-0 2020 The effect of vitamin D supplementation on insulin-like growth factor-1: A systematic review and meta-analysis of randomized controlled trials. Vitamin D 14-23 insulin like growth factor 1 Homo sapiens 43-71 32444034-1 2020 PURPOSE: There is equivocality regarding the interaction between vitamin D and insulin-like growth factor-1 (IGF-1). Vitamin D 65-74 insulin like growth factor 1 Homo sapiens 109-114 32444034-2 2020 Thus, the aim of this study was to elucidate the effect of vitamin D supplementation on serum levels of IGF-1 by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs). Vitamin D 59-68 insulin like growth factor 1 Homo sapiens 104-109 32444034-3 2020 METHODS: PubMed, Scopus, and ISI Web of Science databases were searched up to May 2019 for RCTs that evaluated the effect of vitamin D supplementation on IGF-1 levels. Vitamin D 125-134 insulin like growth factor 1 Homo sapiens 154-159 31816443-0 2020 The influence of vitamin D supplementation on IGF-1 levels in humans: A systematic review and meta-analysis. Vitamin D 17-26 insulin like growth factor 1 Homo sapiens 46-51 31816443-1 2020 BACKGROUND: Inconsistencies exist with regard to influence of vitamin D supplementation on IGF-1 levels. Vitamin D 62-71 insulin like growth factor 1 Homo sapiens 91-96 31816443-3 2020 To address these inconsistencies, this study was conducted to determine the impact of vitamin D supplementation on IGF-1 levels through a systematic review and meta-analysis of randomized controlled trials (RCTs). Vitamin D 86-95 insulin like growth factor 1 Homo sapiens 115-120 31816443-4 2020 METHODS: A comprehensive systematic search was carried out in PubMed/MEDLINE, Web of Science, SCOPUS and Embase for RCTs that investigated the impact of vitamin D intake on circulating IGF-1 levels from inception until June 2019. Vitamin D 153-162 insulin like growth factor 1 Homo sapiens 185-190 31816443-7 2020 RESULTS: Pooled results from eight studies demonstrated an overall non-significant increase in IGF-1 following vitamin D supplementation (WMD: 4 ng/ml, 95 % CI: -4 to 11). Vitamin D 111-120 insulin like growth factor 1 Homo sapiens 95-100 31816443-9 2020 The subgroup analyses showed that vitamin D dosage of <=1000 IU/day (WMD: 10 ng/ml) significantly increased IGF-1 compared to the vitamin D dosage of <1000 IU/day (WMD: -1 ng/ml). Vitamin D 34-43 insulin like growth factor 1 Homo sapiens 108-113 31816443-11 2020 In the epidemiological cohort study, participants under 60 years of age with a higher dietary vitamin D intake had significantly higher IGF-1 levels when compared to those with lower dietary vitamin D intake in second categories. Vitamin D 94-103 insulin like growth factor 1 Homo sapiens 136-141 31816443-12 2020 CONCLUSION: The main results indicate a non-significant increase in IGF-1 following vitamin D supplementation. Vitamin D 84-93 insulin like growth factor 1 Homo sapiens 68-73 31816443-13 2020 Additionally, vitamin D dosages of <1000 IU/day and intervention durations of <12 weeks significantly raised IGF-1 levels. Vitamin D 14-23 insulin like growth factor 1 Homo sapiens 109-114 31375874-11 2019 CONCLUSIONS: Our study showed that in healthy adolescents with low vitamin D status and calcium intake, mild vitamin D and mild to modest calcium supplements increased IGF-1 but did not affect bone mineralization or turnover. Vitamin D 109-118 insulin like growth factor 1 Homo sapiens 168-173 29476020-8 2018 In presence of vitamin D receptor (VDR), DBP promoted cell aggression (invasion and doubling time) via activation of the insulin-like growth factor-1/insulin-like growth factor-binding protein-2/Akt axis, and induced suppression of vitamin D-responsive genes. Vitamin D 15-24 insulin like growth factor 1 Homo sapiens 121-149 31354810-1 2019 Objective: This study aims to investigate the effect of combining calcium and vitamin D supplements with metformin on menstrual cycle abnormalities, gonadotropins, and IGF-1 system in vitamin D-deficient/insufficient PCOS women. Vitamin D 78-87 insulin like growth factor 1 Homo sapiens 168-173 31354810-1 2019 Objective: This study aims to investigate the effect of combining calcium and vitamin D supplements with metformin on menstrual cycle abnormalities, gonadotropins, and IGF-1 system in vitamin D-deficient/insufficient PCOS women. Vitamin D 184-193 insulin like growth factor 1 Homo sapiens 168-173 31354810-10 2019 Conclusions: Calcium and vitamin D supplements can support metformin effect on regulation of menstrual cycle irregularity in vitamin D-deficient/insufficient PCOS patients, but this effect is not associated with any significant changes in gonadotropins or IGF-1 system. Vitamin D 25-34 insulin like growth factor 1 Homo sapiens 256-261 30885216-5 2019 MAIN BODY: We reviewed and analyzed the clinical studies that have considered the relationship between vitamin D and the GH/IGF-1 axis in pediatric populations. Vitamin D 103-112 insulin like growth factor 1 Homo sapiens 124-129 30885216-6 2019 We found two main areas of interest: the vitamin D deficiency status in patients affected by GH deficit (GHD) and the relationship between serum vitamin D metabolites and IGF-1. Vitamin D 145-154 insulin like growth factor 1 Homo sapiens 171-176 29470176-11 2018 The serum IGF-1 and IGFBP-3 levels increased significantly post supplementation with vitamin D. Vitamin D 85-94 insulin like growth factor 1 Homo sapiens 10-15 29742726-9 2018 Subjects with lower baseline serum IGF-II, IGFBP-2, and IGF-1/IGFBP-3 ratio are more sensitive to acute vitamin D status changes. Vitamin D 104-113 insulin like growth factor 1 Homo sapiens 56-61 29742726-12 2018 This study proposes that changes in circulating IGF-I and IGFBP-3 are modulated by vitamin D supplementation and can be taken into consideration in investigations involving vitamin D correction. Vitamin D 83-92 insulin like growth factor 1 Homo sapiens 48-53 29742726-12 2018 This study proposes that changes in circulating IGF-I and IGFBP-3 are modulated by vitamin D supplementation and can be taken into consideration in investigations involving vitamin D correction. Vitamin D 173-182 insulin like growth factor 1 Homo sapiens 48-53 29742726-13 2018 Moreover, increase in serum 25(OH)D and IGF-I/IGFBP-3 molar ratio are more sensitive markers for the response to vitamin D supplementation in Saudi population. Vitamin D 113-122 insulin like growth factor 1 Homo sapiens 40-45 29470176-13 2018 Vitamin D supplementation resulted in a significant increase in serum IGF-1 levels in VDD pre-pubertal girls. Vitamin D 0-9 insulin like growth factor 1 Homo sapiens 70-75 29368588-1 2018 BACKGROUND: Recent studies have shown a relationship between vitamin D status and growth hormone (GH) and insulin-like growth factor 1 (IGF1). Vitamin D 61-70 insulin like growth factor 1 Homo sapiens 106-134 29368588-1 2018 BACKGROUND: Recent studies have shown a relationship between vitamin D status and growth hormone (GH) and insulin-like growth factor 1 (IGF1). Vitamin D 61-70 insulin like growth factor 1 Homo sapiens 136-140 28537499-10 2017 CONCLUSION: Vitamin D can protect the degeneration of intervertebral disc and improve the content of transforming growth factor-beta and insulin-like growth factor-1 in the intervertebral disc, which provides a new idea for the prevention and treatment of degenerative changes of the intervertebral disc in diabetic patients. Vitamin D 12-21 insulin like growth factor 1 Homo sapiens 137-165 28629132-0 2017 Effects of Vitamin D Supplementation on IGF-1 and Calcitriol: A Randomized-Controlled Trial. Vitamin D 11-20 insulin like growth factor 1 Homo sapiens 40-45 28629132-1 2017 Increasing evidence suggests a possible interaction between vitamin D and insulin-like growth factor-1 (IGF-1). Vitamin D 60-69 insulin like growth factor 1 Homo sapiens 104-109 29649340-1 2018 The relationships between bone turnover, the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and vitamin D are complex, but still not fully explained. Vitamin D 109-118 insulin like growth factor 1 Homo sapiens 93-98 25394580-5 2014 Of the former, vitamin D metabolites, parathyroid hormone, and insulin-like growth factor-I indicate responses to variations in the supply of bone-related nutrients, such as vitamin D, Ca, inorganic phosphate and protein. Vitamin D 174-183 insulin like growth factor 1 Homo sapiens 63-91 28095043-0 2017 SERUM INSULIN-LIKE GROWTH FACTOR 1 IN LEBANESE SCHOOLCHILDREN AND ITS RELATION TO VITAMIN D AND FERRITIN LEVELS. Vitamin D 82-91 insulin like growth factor 1 Homo sapiens 6-34 28236062-8 2017 IGF-1correlates positively with serum vitamin D, BMI, and BMD. Vitamin D 38-47 insulin like growth factor 1 Homo sapiens 0-5 26987336-1 2016 Recent studies have shown that vitamin D has an impact on the production and secretion of IGF-I in the liver. Vitamin D 31-40 insulin like growth factor 1 Homo sapiens 90-95 26987336-8 2016 The results of our study suggest that vitamin D deficiency could influence IGF-I concentrations in children and adolescents with growth hormone deficiency, and vitamin D deficiency should be normalized before the measurement of IGF-I concentrations to obtain the reliable and unbiased IGF-I values. Vitamin D 38-47 insulin like growth factor 1 Homo sapiens 75-80 28372721-3 2017 On the other hand, vitamin D increases circulating IGF-I and the vitamin D deficiency should be normalized before measurement of IGF-I concentrations to obtain reliable and unbiased IGF-I values. Vitamin D 19-28 insulin like growth factor 1 Homo sapiens 51-56 28372721-4 2017 Indeed, linear growth after treatment of nutritional vitamin D deficiency seems to be mediated through activation of the GH/IGF-I axis and it suggests an important role of vitamin D as a link between the proliferating cartilage cells of the growth plate and GH/IGF-I secretion. Vitamin D 53-62 insulin like growth factor 1 Homo sapiens 124-129 28372721-8 2017 The current review summarizes the available data on vitamin D in the main disorders of the GH/IGF-I axis, providing an overview of the current state of the art. Vitamin D 52-61 insulin like growth factor 1 Homo sapiens 94-99 24005315-0 2013 Vitamin D increases circulating IGF1 in adults: potential implication for the treatment of GH deficiency. Vitamin D 0-9 insulin like growth factor 1 Homo sapiens 32-36 25150940-0 2014 Vitamin D modulates the association of circulating insulin-like growth factor-1 with carotid artery intima-media thickness. Vitamin D 0-9 insulin like growth factor 1 Homo sapiens 51-79 25150940-3 2014 Since vitamin D is also implicated in vascular protection and affects IGF-1 biology, we hypothesized that it would influence the effect of IGF-1 on IMT. Vitamin D 6-15 insulin like growth factor 1 Homo sapiens 70-75 25150940-3 2014 Since vitamin D is also implicated in vascular protection and affects IGF-1 biology, we hypothesized that it would influence the effect of IGF-1 on IMT. Vitamin D 6-15 insulin like growth factor 1 Homo sapiens 139-144 25150940-9 2014 CONCLUSIONS: Circulating IGF-1 is vasoprotective primarily when vitamin D levels are low. Vitamin D 64-73 insulin like growth factor 1 Homo sapiens 25-30 24090688-7 2013 On simple linear analysis, the vitamins found associated with serum IGF-1 levels were: folates (r: -0.25; p = 0.003); vitamin E (r: -0.21; p = 0.01); vitamin D (r: -0.17; p = 0.03); and riboflavin (r: -0.16; p=0.03). Vitamin D 150-159 insulin like growth factor 1 Homo sapiens 68-73 24005315-1 2013 OBJECTIVES: Previous studies suggested that vitamin D modulates circulating IGF1. Vitamin D 44-53 insulin like growth factor 1 Homo sapiens 76-80 24005315-4 2013 The frequency of IGF1 values >=50th age- and sex-specific percentile in relation to vitamin D status, as determined by the concentration of 25-hydroxyvitamin D (25(OH)D), was retrospectively assessed in 69 GHD patients (57.4+-16.6 years) on stable hormone replacement and with 25(OH)D and IGF1 concurrently measured. Vitamin D 87-96 insulin like growth factor 1 Homo sapiens 17-21 24005315-9 2013 Logistic regression with adjustment for recombinant human GH (rhGH) dose, vitamin D supplements, gender, use of thyroid hormones, corticosteroids or estrogen/testosterone, and season revealed a significant positive association between >=15 ng/ml 25(OH)D and IGF1 >=50th percentile (OR 4.4, 95% CI 1.0-18.8, P<0.05). Vitamin D 74-83 insulin like growth factor 1 Homo sapiens 261-265 24005315-11 2013 CONCLUSIONS: Vitamin D increases circulating IGF1 in adults. Vitamin D 13-22 insulin like growth factor 1 Homo sapiens 45-49 24005315-12 2013 As a result, a better vitamin D status may ease the achievement of normal IGF1 values in GHD. Vitamin D 22-31 insulin like growth factor 1 Homo sapiens 74-78 22562539-9 2012 Vitamin D deficiency has been associated with higher rates of diabetes and colorectal cancer, particularly in individuals with high serum insulin and IGF-1 levels. Vitamin D 0-9 insulin like growth factor 1 Homo sapiens 150-155 23789983-10 2013 Current evidence indicates that, in breast tumours, vitamin D modulates the IGF-I/IGFBP ratio to decrease proliferation and increase apoptosis. Vitamin D 52-61 insulin like growth factor 1 Homo sapiens 76-81 23109222-7 2013 Vitamin D status was an independent predictor of GH-IGF-I axis and supplementation with vitamin D decreased IGF-I/IGFBP-3 ratio in subjects without severe obesity. Vitamin D 0-9 insulin like growth factor 1 Homo sapiens 52-57 23109222-7 2013 Vitamin D status was an independent predictor of GH-IGF-I axis and supplementation with vitamin D decreased IGF-I/IGFBP-3 ratio in subjects without severe obesity. Vitamin D 88-97 insulin like growth factor 1 Homo sapiens 108-113 23109222-9 2013 Adverse effects of GH-IGF-I axis on glucose metabolism and the development of metabolic syndrome may be in part associated with the changes in vitamin D status. Vitamin D 143-152 insulin like growth factor 1 Homo sapiens 22-27 22728278-6 2013 Vitamin D and miRNAs regulate and complement IGF-1 mediated function and neuroprotective efficacy via modulation of IGF-1 availability and neural stem cell and immune cell proliferation, differentiation and secretions. Vitamin D 0-9 insulin like growth factor 1 Homo sapiens 45-50 22728278-6 2013 Vitamin D and miRNAs regulate and complement IGF-1 mediated function and neuroprotective efficacy via modulation of IGF-1 availability and neural stem cell and immune cell proliferation, differentiation and secretions. Vitamin D 0-9 insulin like growth factor 1 Homo sapiens 116-121 23789983-2 2013 Vitamin D has been shown to increase circulating IGF-I and IGFBP-3, with the consistent finding of a positive correlation between vitamin D and IGF-I serum values in population-based cohorts of healthy subjects. Vitamin D 0-9 insulin like growth factor 1 Homo sapiens 49-54 23789983-2 2013 Vitamin D has been shown to increase circulating IGF-I and IGFBP-3, with the consistent finding of a positive correlation between vitamin D and IGF-I serum values in population-based cohorts of healthy subjects. Vitamin D 0-9 insulin like growth factor 1 Homo sapiens 144-149 23789983-3 2013 The modulation of IGF-I and IGFBP-3 concentrations by vitamin D may impact recombinant human (rh) GH dosing for the treatment of GHD. Vitamin D 54-63 insulin like growth factor 1 Homo sapiens 18-23 23754696-3 2013 In addition, vitamin D influences muscle metabolism by genomic and non-genomic actions, including stimulation of the insulin-like-growth-factor 1 (IGF1), a major regulator of muscle trophism. Vitamin D 13-22 insulin like growth factor 1 Homo sapiens 117-145 23754696-3 2013 In addition, vitamin D influences muscle metabolism by genomic and non-genomic actions, including stimulation of the insulin-like-growth-factor 1 (IGF1), a major regulator of muscle trophism. Vitamin D 13-22 insulin like growth factor 1 Homo sapiens 147-151 23930605-10 2013 Pre-clinical trials have shown vitamin D to not only decrease BPH cell and prostate cell proliferation alone, but also when induced by known growth promoting molecules such as IL-8, Des (1-3) IGF-1, testosterone and dihydrotestosterone. Vitamin D 31-40 insulin like growth factor 1 Homo sapiens 192-197 23109222-2 2013 Our hypothesis was that there is a relation between GH, IGF-I, and 25(OH)D; and that vitamin D supplementation may have an effect on the levels of GH, IGF-I, and IGF-I/IGFBP-3 ratio. Vitamin D 85-94 insulin like growth factor 1 Homo sapiens 151-156 23109222-2 2013 Our hypothesis was that there is a relation between GH, IGF-I, and 25(OH)D; and that vitamin D supplementation may have an effect on the levels of GH, IGF-I, and IGF-I/IGFBP-3 ratio. Vitamin D 85-94 insulin like growth factor 1 Homo sapiens 151-156 21310542-3 2011 In this article we explore how vitamin D may promote VGEF, IGF-1 and axonal regeneration delaying ALS progression. Vitamin D 31-40 insulin like growth factor 1 Homo sapiens 59-64 20671418-0 2011 Vitamin D status may contribute to serum insulin-like growth factor I concentrations in healthy subjects. Vitamin D 0-9 insulin like growth factor 1 Homo sapiens 41-69 20671418-1 2011 OBJECTIVE: The aim of the study was to evaluate whether vitamin D [25-(OH) D3] status affects serum IGFI concentrations in healthy subjects. Vitamin D 56-65 insulin like growth factor 1 Homo sapiens 100-104 19966181-9 2010 We propose that circulating 25OHD, by virtue of its local conversion to 1,25(OH)(2)D catalyzed by basal CYP27B1 in hMSCs, amplifies vitamin D signaling through IGF-I up-regulation, which in turn induces CYP27B1 in a feed-forward mechanism to potentiate osteoblast differentiation initiated by IGF-I. Vitamin D 132-141 insulin like growth factor 1 Homo sapiens 160-165 22216097-7 2011 CONCLUSION: The results from this study suggest that improving vitamin D status may help lower risk of colorectal cancer associated with higher IGF-1/IGFBP-3 ratio or C-peptide levels. Vitamin D 63-72 insulin like growth factor 1 Homo sapiens 144-149 19966181-9 2010 We propose that circulating 25OHD, by virtue of its local conversion to 1,25(OH)(2)D catalyzed by basal CYP27B1 in hMSCs, amplifies vitamin D signaling through IGF-I up-regulation, which in turn induces CYP27B1 in a feed-forward mechanism to potentiate osteoblast differentiation initiated by IGF-I. Vitamin D 132-141 insulin like growth factor 1 Homo sapiens 293-298 16397276-5 2006 The negative associations of vitamin D or calcium intakes with breast density were stronger among women with IGF-I levels above the median (beta = -2.8, P = 0.002 and beta = -2.5, P = 0.002, respectively) compared with those with IGF-I levels below or equal to the median (beta = -0.8, P = 0.38 and beta = -1.1, P = 0.21; P(interaction) = 0.09 and 0.16, respectively). Vitamin D 29-38 insulin like growth factor 1 Homo sapiens 109-114 18504173-8 2008 Correlation both with markers of bone metabolism and vitamin D metabolites showed the important role of GH/IGF-I axis in modulating the availability of calcium in chronic conditions. Vitamin D 53-62 insulin like growth factor 1 Homo sapiens 107-112 18078865-14 2008 These data denote that the accelerated linear growth after treatment of nutritional vitamin D deficiency is mediated through activation of the growth hormone/IGF-I system and suggests an important role of vitamin D as a link between the proliferating cartilage cells of the growth plate and growth hormone/IGF-I secretion. Vitamin D 84-93 insulin like growth factor 1 Homo sapiens 158-163 18078865-14 2008 These data denote that the accelerated linear growth after treatment of nutritional vitamin D deficiency is mediated through activation of the growth hormone/IGF-I system and suggests an important role of vitamin D as a link between the proliferating cartilage cells of the growth plate and growth hormone/IGF-I secretion. Vitamin D 84-93 insulin like growth factor 1 Homo sapiens 306-311 19519975-7 2009 The present open trial suggests that fortified soft plain cheese consumed by elderly women with vitamin D insufficiency can reduce bone resorption markers by positively influencing Ca and protein economy, as expressed by decreased PTH and increased IGF-I, respectively. Vitamin D 96-105 insulin like growth factor 1 Homo sapiens 249-254 16724947-0 2006 The role of insulin-like growth factor I components in the regulation of vitamin D. Vitamin D 73-82 insulin like growth factor 1 Homo sapiens 12-40 16724947-4 2006 The mechanisms by which IGF-I may influence bone metabolism is not fully understood but they are a predictor of bone mass density and are positively associated with vitamin D concentrations. Vitamin D 165-174 insulin like growth factor 1 Homo sapiens 24-29 16397276-5 2006 The negative associations of vitamin D or calcium intakes with breast density were stronger among women with IGF-I levels above the median (beta = -2.8, P = 0.002 and beta = -2.5, P = 0.002, respectively) compared with those with IGF-I levels below or equal to the median (beta = -0.8, P = 0.38 and beta = -1.1, P = 0.21; P(interaction) = 0.09 and 0.16, respectively). Vitamin D 29-38 insulin like growth factor 1 Homo sapiens 230-235 16397276-7 2006 This is the first study to report that the negative relation of vitamin D and calcium intakes with breast density may be seen primarily among women with high IGF-I or high IGFBP-3 levels. Vitamin D 64-73 insulin like growth factor 1 Homo sapiens 158-163 11179739-10 2001 However, the ability of these agents to suppress cPLA2 activation was abrogated by co-treatment with CB1093, suggesting a role for arachidonic acid release in the caspase-independent mechanism by which vitamin D analogs prevent the protective effects of IGF-I on breast cancer cell survival. Vitamin D 202-211 insulin like growth factor 1 Homo sapiens 254-259 14671148-12 2003 Pegvisomant-induced normalization of serum IGF-I results in a decrease in markers of bone and soft tissue turnover to levels observed in age-matched controls, and these changes are accompanied by an increase in PTH and a decrease in 1,25-(OH)(2) vit D. Vitamin D 246-251 insulin like growth factor 1 Homo sapiens 43-48 12908448-7 2003 Evidence has also emerged that vitamin D compounds can also affect the growth-promoting pathways initiated by two important factors involved in breast cancer cell promotion; namely the insulin-like growth factor I (IGF-I) and oestrogen-receptor (ER) pathways. Vitamin D 31-40 insulin like growth factor 1 Homo sapiens 185-213 12014835-5 2002 Reduced IGF-I signalling is involved in muscle atrophy and results from decreased muscle exercise, reduced growth hormone and insulin levels, reduced vitamin D, and treatment with drugs like corticosteroids, dexamethasone, and cyclosporin. Vitamin D 150-159 insulin like growth factor 1 Homo sapiens 8-13 12119479-10 2002 Significant correlations between serum IGF-1 concentrations and vitamin D concentrations were noted only at 6 months. Vitamin D 64-73 insulin like growth factor 1 Homo sapiens 39-44 10454569-3 1999 Here we show that the classical growth factor insulin-like growth factor I (IGF-I) potently promotes vitamin D(3)-induced macrophage differentiation of promyeloid cells, as assessed by measurement of a coordinate increase in expression of the integrin alpha subunit CD11b, the CD14 lipopolysaccharide receptor, and the macrophage-specific esterase, alpha-naphthyl acetate esterase, as early as 24 h following initiation of terminal differentiation. Vitamin D 101-110 insulin like growth factor 1 Homo sapiens 76-81 10674019-0 1999 Vitamin D analogues suppress IGF-I signalling and promote apoptosis in breast cancer cells. Vitamin D 0-9 insulin like growth factor 1 Homo sapiens 29-34 10674019-4 1999 The aim of this study was to determine the relationship between inhibition of IGF-I responsiveness and induction of apoptosis by vitamin D analogues in breast cancer cells. Vitamin D 129-138 insulin like growth factor 1 Homo sapiens 78-83 10674019-5 1999 Vitamin D analogues EB1089 and CB1093 inhibited autonomous and IGF-I-stimulated growth of MCF-7 and T47D cells and autonomous growth of IGF-I-insensitive Hs578T cells. Vitamin D 0-9 insulin like growth factor 1 Homo sapiens 63-68 10674019-5 1999 Vitamin D analogues EB1089 and CB1093 inhibited autonomous and IGF-I-stimulated growth of MCF-7 and T47D cells and autonomous growth of IGF-I-insensitive Hs578T cells. Vitamin D 0-9 insulin like growth factor 1 Homo sapiens 136-141 10674019-7 1999 Co-treatment with vitamin D analogues prevented the anti-apoptotic effects of IGF-I. Vitamin D 18-27 insulin like growth factor 1 Homo sapiens 78-83 10674019-11 1999 Our findings suggest that vitamin D analogues inhibit IGF-I signalling pathways to promote apoptosis in breast cancer cells. Vitamin D 26-35 insulin like growth factor 1 Homo sapiens 54-59 10427145-5 1999 We report here that the vitamin D analogue EB1089 interferes with the IGF-IR signaling pathway by attenuating IGF-I-induced tyrosine phosphorylation of IRS-1, and to a lesser extent, IRS-2. Vitamin D 24-33 insulin like growth factor 1 Homo sapiens 70-75 10454569-4 1999 Addition of IGF-I to cells undergoing vitamin D(3)-induced differentiation also leads to an early increase in expression of cyclin E, phosphorylation of the retinoblastoma tumor suppressor protein, and a doubling of the cell number. Vitamin D 38-47 insulin like growth factor 1 Homo sapiens 12-17 9591744-9 1998 It is suggested that increasing the circulating IGF-I concentration through aggressive nutritional therapy and/or GH/IGF-I therapy with supplementation with vitamin D and/or calcium might improve bone growth and mineralization and prevent the development of osteoporosis and consequent fractures in these patients. Vitamin D 157-166 insulin like growth factor 1 Homo sapiens 117-122 9591744-9 1998 It is suggested that increasing the circulating IGF-I concentration through aggressive nutritional therapy and/or GH/IGF-I therapy with supplementation with vitamin D and/or calcium might improve bone growth and mineralization and prevent the development of osteoporosis and consequent fractures in these patients. Vitamin D 157-166 insulin like growth factor 1 Homo sapiens 48-53 9513092-2 1998 Both vitamin D analogues inhibited IGF-1 stimulated growth of MCF-7 cells and enhanced the production of IGFBP-3 as determined by Western-ligand blotting. Vitamin D 5-14 insulin like growth factor 1 Homo sapiens 35-40 9379127-0 1997 Vitamin D derivatives inhibit the mitogenic effects of IGF-I on MCF-7 human breast cancer cells. Vitamin D 0-9 insulin like growth factor 1 Homo sapiens 55-60 9379127-9 1997 Our findings demonstrate that vitamin D derivatives limit responsiveness of MCF-7 cells to the mitogenic effects of IGF-I, which may be mediated by reduction of IGF-I receptor expression. Vitamin D 30-39 insulin like growth factor 1 Homo sapiens 116-121 1924097-4 1991 Proliferation and differentiation of cartilage cells (i.e., chondrocytes) as studied mostly in culture, is regulated by various endocrine, paracrine, and autocrine agents such as growth hormone, insulin-like growth factor-I (IGF-I), transforming growth factor (TGE-beta), and vitamin D metabolites (1,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol). Vitamin D 276-285 insulin like growth factor 1 Homo sapiens 195-223 9037126-11 1997 The results of this study confirmed the actions of GH on renal tubules with increases in calcium excretion and phosphorus reabsorption, and indicate that the action of GH on modulating vitamin D metabolism may be IGF-I mediated, not PTH mediated. Vitamin D 185-194 insulin like growth factor 1 Homo sapiens 213-218 2180972-2 1990 These studies suggest that this adaptive change in vitamin D metabolism is mediated through insulin-like growth factor-I (IGF-I) and/or insulin. Vitamin D 51-60 insulin like growth factor 1 Homo sapiens 92-120 2180972-2 1990 These studies suggest that this adaptive change in vitamin D metabolism is mediated through insulin-like growth factor-I (IGF-I) and/or insulin. Vitamin D 51-60 insulin like growth factor 1 Homo sapiens 122-127 2059879-4 1991 The active vitamin D metabolite 1,25-dihydroxycholecalciferol [1,25(OH)2D3] slightly increased the IGF-I level, but the increase was not statistically significant. Vitamin D 11-20 insulin like growth factor 1 Homo sapiens 99-104