PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19920212-8 2010 We identified novel ACTH-induced changes in 1) genes involved in vitamin D (Cyp27b1, Cyp24a1, Gc) and calcium (Sgk, Calb1, Trpv5) metabolism associated with calciuria and phosphaturia; 2) genes that would be predicted to desensitize the kidney to glucocorticoid action (Nr3c1, Hsd11b1, Fkbp5); and 3) genes encoding transporters of enzyme systems associated with xenobiotic metabolism and oxidative stress. Vitamin D 65-74 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 76-83 19829383-4 2009 Reflecting vitamin-D-mediated transrepression of the CYP27B1 gene by the negative vitamin D response element (nVDRE), methylation of CpG sites ((5m)CpG) is induced by vitamin D in this gene promoter. Vitamin D 11-20 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 53-60 19829383-4 2009 Reflecting vitamin-D-mediated transrepression of the CYP27B1 gene by the negative vitamin D response element (nVDRE), methylation of CpG sites ((5m)CpG) is induced by vitamin D in this gene promoter. Vitamin D 82-91 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 53-60 19829383-4 2009 Reflecting vitamin-D-mediated transrepression of the CYP27B1 gene by the negative vitamin D response element (nVDRE), methylation of CpG sites ((5m)CpG) is induced by vitamin D in this gene promoter. Vitamin D 167-176 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 53-60 19320717-6 2009 Cyp27b1 was expressed in tooth germ, suggesting that tooth germ can synthesize active vitamin D. Vitamin D 86-95 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 0-7 15972816-0 2005 Identification of the amino acid residue of CYP27B1 responsible for binding of 25-hydroxyvitamin D3 whose mutation causes vitamin D-dependent rickets type 1. Vitamin D 89-98 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 44-51 18029472-0 2007 High dietary vitamin D prevents hypocalcemia and osteomalacia in CYP27B1 knockout mice. Vitamin D 13-22 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 65-72 18029472-6 2007 High VD3 restored expression of vitamin D-regulated genes in intestine (calbindin D(9K)) and kidney (CYP27B1, 24-hydroxylase, calbindin D(9K)) of KO mice. Vitamin D 32-41 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 101-108 16371465-1 2006 The hormonally active form of vitamin D(3),1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], is synthesized in the kidney through a tightly regulated reaction catalyzed by 25-hydroxyvitamin D(3)-1alpha-hydroxylase (1alpha-hydroxylase), the product of the CYP27B1 gene. Vitamin D 30-39 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 173-214 16371465-1 2006 The hormonally active form of vitamin D(3),1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], is synthesized in the kidney through a tightly regulated reaction catalyzed by 25-hydroxyvitamin D(3)-1alpha-hydroxylase (1alpha-hydroxylase), the product of the CYP27B1 gene. Vitamin D 30-39 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 256-263 16177194-10 2005 The expression of the mRNA for the VDR and the 1alpha-OHase was 37- and 6-fold higher, respectively, in the vitamin D-sufficient mice compared with the vitamin D-deficient mice. Vitamin D 108-117 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 47-59 16177194-10 2005 The expression of the mRNA for the VDR and the 1alpha-OHase was 37- and 6-fold higher, respectively, in the vitamin D-sufficient mice compared with the vitamin D-deficient mice. Vitamin D 152-161 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 47-59 16177194-12 2005 The tumor expression of VDR and 1alpha-OHase indicates possible autocrine/paracrine cell growth regulation by vitamin D. Vitamin D 110-119 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 24-44 15225794-1 2004 The treatment of choice for pseudo Vitamin D deficiency rickets (PDDR), caused by mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1; 1alpha-OHase) gene, is replacement therapy with 1,25(OH)(2)D(3). Vitamin D 35-44 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 65-69 15225794-1 2004 The treatment of choice for pseudo Vitamin D deficiency rickets (PDDR), caused by mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1; 1alpha-OHase) gene, is replacement therapy with 1,25(OH)(2)D(3). Vitamin D 35-44 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 139-146 15225761-1 2004 The enzyme 25-hydroxyvitamin D 1-hydroxylase (CYP27B1) is the rate limiting enzyme in the two-step activation process of Vitamin D to its active form 1,25-dihydroxyvitamin D (1,25D) and is located in the mitochondrial fraction of the proximal tubular cells of the kidney. Vitamin D 121-130 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 46-53 15225794-1 2004 The treatment of choice for pseudo Vitamin D deficiency rickets (PDDR), caused by mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1; 1alpha-OHase) gene, is replacement therapy with 1,25(OH)(2)D(3). Vitamin D 35-44 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 148-160 29710028-4 2018 The protein expressions of markers linked with the vitamin D action were altered by VDD (vitamin D receptor VDR, 25-hydroxyvitamin D-24-hydroxylase CYP24A1, CYP27B1, and CYP2R1). Vitamin D 51-60 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 157-164 12689675-1 2003 Mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase gene (CYP27B1; 1alpha-OHase) cause pseudo vitamin D deficiency rickets (PDDR), while mutations in the vitamin D receptor (VDR) cause hereditary vitamin D resistance rickets. Vitamin D 27-36 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 62-69 12689675-1 2003 Mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase gene (CYP27B1; 1alpha-OHase) cause pseudo vitamin D deficiency rickets (PDDR), while mutations in the vitamin D receptor (VDR) cause hereditary vitamin D resistance rickets. Vitamin D 27-36 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 71-83 12689675-1 2003 Mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase gene (CYP27B1; 1alpha-OHase) cause pseudo vitamin D deficiency rickets (PDDR), while mutations in the vitamin D receptor (VDR) cause hereditary vitamin D resistance rickets. Vitamin D 27-36 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 128-132 12674324-1 2003 The treatment of choice for pseudo-vitamin D deficiency rickets (PDDR), caused by mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1; 1alpha-OHase) gene, is replacement therapy with 1,25(OH)2D3. Vitamin D 35-44 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 65-69 12674324-1 2003 The treatment of choice for pseudo-vitamin D deficiency rickets (PDDR), caused by mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1; 1alpha-OHase) gene, is replacement therapy with 1,25(OH)2D3. Vitamin D 35-44 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 139-146 12674324-1 2003 The treatment of choice for pseudo-vitamin D deficiency rickets (PDDR), caused by mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1; 1alpha-OHase) gene, is replacement therapy with 1,25(OH)2D3. Vitamin D 35-44 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 148-160 33535006-2 2021 To investigate the effects of 1,25-Vit D3 and 24,25-Vit D3 on corneal fibroblast expression of the vitamin D-associated enzymes CYP27B1 and CYP24A1 and the roles of the vitamin D receptor (VDR) and protein disulfide isomerase, family A, member 3 (Pdia3) in these cells. Vitamin D 99-108 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 128-135 31629064-0 2020 Mechanistic homeostasis of vitamin D metabolism in the kidney through reciprocal modulation of Cyp27b1 and Cyp24a1 expression. Vitamin D 27-36 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 95-102 31702812-0 2019 BCG stimulation promotes dendritic cell proliferation and expression of VDR and CYP27B1 in vitamin D-deficient mice. Vitamin D 91-100 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 80-87 30281599-7 2018 Accordingly, in Cyp27b1-/-mice, the pharmacological effects of exogenously administered active vitamin D derivatives can be analyzed without being affected by 1alpha,25D3. Vitamin D 95-104 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 16-23 29371756-4 2018 In fact, plasma 1,25-dihydroxyvitamin D levels showed a significant correlation with vitamin D metabolism gene Cyp27b1 and Cyp24a1 mRNA expression in the high phosphate group. Vitamin D 30-39 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 111-118 12421875-5 2002 Levels are determined by skin exposure to ultraviolet light or, to a minor extent, nutritional uptake and by subsequent conversion of the precursor vitamin D to the active hormone by the cytochrome P450 hydroxylases CYP27A1, CYP27B1 (responsible for synthesis) and CYP24 (responsible for catabolism) in liver and kidney. Vitamin D 148-157 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 225-232 11416220-1 2001 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D [1alpha,25(OH)2D], is synthesized from its precursor 25 hydroxyvitamin D [25(OH)D] via the catalytic action of the 25(OH)D-1alpha-hydroxylase [1alpha(OH)ase] enzyme. Vitamin D 19-28 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 174-200 11416220-1 2001 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D [1alpha,25(OH)2D], is synthesized from its precursor 25 hydroxyvitamin D [25(OH)D] via the catalytic action of the 25(OH)D-1alpha-hydroxylase [1alpha(OH)ase] enzyme. Vitamin D 19-28 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 202-215 9295274-1 1997 Renal 25-hydroxyvitamin D3 1alpha-hydroxylase [1alpha(OH)ase] catalyzes metabolic activation of 25-hydroxyvitamin D3 into 1alpha, 25-dihydroxyvitamin D3 [1alpha,25(OH)2D3], an active form of vitamin D, and is inhibited by 1alpha,25(OH)2D3. Vitamin D 16-25 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 47-60 9295274-4 1997 These results indicate that the negative feedback regulation of active vitamin D synthesis is mediated by 1alpha(OH)ase through liganded VDR. Vitamin D 71-80 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 106-119 31945466-0 2020 25(OH)D3 stimulates the expression of vitamin D target genes in renal tubular cells when Cyp27b1 is abrogated. Vitamin D 38-47 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 89-96 29653103-2 2018 Both 25-hydroxy vitamin D3 1alpha-hydroxylase (CYP27B1) and 25-hydroxyvitamin D3 24-hydroxylase (CYP24A1) modulate blood levels of 1,25-dihydroxyvitamin D3, an activated form of vitamin D. Vitamin D 16-25 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 47-54 29771914-2 2018 Vitamin D is first modified in the liver by the 25-hydroxylases CYP2R1 and CYP27A1 and further activated in the kidney by the 1alpha-hydroxylase CYP27B1, while the renal 24-hydroxylase CYP24A1 catalyzes the first step of its inactivation. Vitamin D 0-9 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 145-152 29488238-8 2018 The composite results show that vitamin D analogs 1alpha(OH)D3 and 25(OH)D3 exhibit cholesterol lowering properties upon activation to 1,25(OH)2 D3 : 1alpha(OH)D3 is rapidly activated by liver enzymes and 25(OH)D3 is slowly activated by renal Cyp27b1 in mouse. Vitamin D 32-41 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 243-250 28922720-6 2017 To our knowledge, this is the first to use 1-alpha-hydroxylase [1alpha(OH)ase] knockout mice which characterized vitamin D deficiency to establish the breast cancer bone metastases model. Vitamin D 113-122 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 64-77 27535551-4 2017 Furthermore, raising serum calcium levels in Cyp27b1-depleted mice directly increased FGF23 levels and indirectly enhanced the action of ambient vitamin D metabolites via the vitamin D receptor. Vitamin D 145-154 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 45-52 28808057-3 2017 Despite its importance in vitamin D metabolism, the molecular mechanisms underlying the regulation of the gene for this enzyme, Cyp27b1, are unknown. Vitamin D 26-35 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 128-135 28938443-6 2017 Vitamin D deficiency further exaggerated colonic Cyp27b1 induction and aggravated colonic inflammation in mice. Vitamin D 0-9 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 49-56 27535551-6 2017 Conditional osteoblastic deletion of Cyp27b1 caused lower serum FGF23 levels, despite normal circulating levels of vitamin D metabolites. Vitamin D 115-124 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 37-44 26704532-4 2016 The 25-hydroxylation involves mainly CYP2R1 and CYP27A1, whereas 1alpha-hydroxylation and 24-hydroxylation are catalyzed by CYP27B1 and CYP24A1, respectively, and are tightly regulated to maintain adequate levels of the active vitamin D hormone, 1alpha,25(OH)2D3. Vitamin D 227-236 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 124-131 28025137-2 2017 It is formed by the hydroxylation of vitamin D at the 1alpha position by 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1) in the kidney. Vitamin D 37-46 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 113-120 28025137-12 2017 Using Cyp27b1-/- mice produced in this study, we can analyze the physiological effects of novel vitamin D derivatives in the absence of endogenous 1alpha,25D3. Vitamin D 96-105 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 6-13 27119753-0 2016 Tumoral Vitamin D Synthesis by CYP27B1 1-alpha-Hydroxylase Delays Mammary Tumor Progression in the PyMT-MMTV Mouse Model and Its Action Involves NF-kappaB Modulation. Vitamin D 8-17 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 31-38 27119753-1 2016 Biologically active vitamin D (1,25-dihydroxycholecalciferol or 1,25(OH)2D) is synthetized from inactive prohormone 25-hydroxycholecalciferol (25(OH)D) by the enzyme CYP27B1 1-alpha-hydroxylase in kidney and several extrarenal tissues including breast. Vitamin D 20-29 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 166-173 28107527-1 2017 The final step in vitamin D activation is catalyzed by 1-alpha-hydroxylase (CYP27B1). Vitamin D 18-27 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 76-83 24247221-3 2014 Mice with disrupted vitamin D action--owing to gene deletion of the nuclear receptor vitamin D receptor (Vdr) or the gene encoding 1alpha-hydroxylase (Cyp27b1)--lose fat mass over time owing to an increase in energy expenditure, whereas mice with increased Vdr-mediated signalling in adipose tissue become obese. Vitamin D 20-29 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 151-158 26176830-1 2015 Vitamin D hydroxylated at carbon 25 (25(OH)D) is generally recognized as a precursor of active vitamin D. Vitamin D 0-9 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 33-36 26176830-1 2015 Vitamin D hydroxylated at carbon 25 (25(OH)D) is generally recognized as a precursor of active vitamin D. Vitamin D 95-104 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 33-36 25237033-1 2015 Vitamin D has pleiotropic extra-skeletal effects which have been noted in mouse models of deletion of either the 25-hydroxy vitamin D 1alpha-hydroxylase enzyme, cyp27b1 (1OHase(-/-) mice) or of the vitamin D receptor (Vdr(-/-) mice); these may be preventable or reversible by either restoring normal signaling of the 1,25(OH)2D/VDR system, or in some cases by restoring normal mineral homeostasis. Vitamin D 0-9 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 161-168 24949660-9 2014 Primary myotubes also expressed functional CYP27B1 as demonstrated by luciferase reporter studies, supporting an autoregulatory vitamin D-endocrine system in muscle. Vitamin D 128-137 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 43-50 22981997-5 2013 We and others have also shown that increased vitamin D activity in mature osteoblasts by increasing levels of VDR or CYP27B1 leads to improved bone mineral volume using two separate transgenic mouse models. Vitamin D 45-54 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 117-124 24019880-1 2013 The mitochondrial enzyme 25-hydroxyvitamin D 1alpha-hydroxylase, which is encoded by the CYP27B1 gene, converts 25OHD to the biological active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D). Vitamin D 35-44 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 89-96 24314866-1 2014 The active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] is synthesized by the 1alpha-hydroxylase, which is encoded by the Cyp27B1 gene. Vitamin D 19-28 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 135-142 21482732-2 2011 Given the high basal expression of CYP27B1 and VDR in trophoblastic cells from the placenta, we hypothesized that anti-inflammatory effects of vitamin D may be particularly important in this organ. Vitamin D 143-152 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 35-42 23858619-0 2013 Vitamin D action: lessons from VDR and Cyp27b1 null mice. Vitamin D 0-9 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 39-46 22648952-10 2012 We found that expression of VDR and CYP27B1 increased significantly at day 7 of regeneration, and these results confirm the expression of Vdr and Cyp27b1 in vivo and suggest a potential role for vitamin D(3) in skeletal muscle regeneration following injury. Vitamin D 195-204 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 36-43 22572998-8 2012 Ovaries of vitamin D(3)-deficient Cyp27b1 null mice responded to exogenous gonadotropins and deposited significantly more oocytes into the oviducts than mice maintained on a vitamin D(3)-replete diet. Vitamin D 11-20 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 34-41 22648952-6 2012 The observation that treatment of C2C12 myoblasts with the inactive form of vitamin D(3), [25(OH)D(3)], inhibited proliferation suggested that CYP27B1 was functionally active. Vitamin D 76-85 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 143-150 22454149-2 2012 Because CYP27B1 (1alpha-hydroxylase), the enzyme catalyzing 1,25(OH)(2)D(3) formation in the kidney, is also expressed in extrarenal tissues, we hypothesize that dietary vitamin D(3) will be converted to 25(OH)D(3) in the body and then to 1,25(OH)(2)D(3) locally in the cancer microenvironment in which it will exert autocrine/paracrine anticancer actions. Vitamin D 170-179 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 8-15 22435627-5 2012 The messenger RNA (mRNA) expressions of calcium binding protein (CaBP-9k) and active vitamin D synthesis enzyme (CYP27B1) in the kidney were increased in mice treated with 20 mg BPA. Vitamin D 85-94 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 113-120 21482732-1 2011 The vitamin D-activating enzyme 1alpha-hydroxylase (CYP27B1) and vitamin D receptor (VDR) support anti-inflammatory responses to vitamin D in many tissues. Vitamin D 4-13 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 52-59 20965147-1 2011 Vitamin D intoxication was produced with oral doses of either vitamin D3 or 25-hydroxyvitamin D3 in CYP27B1 -/- (1alpha-hydroxylase knockout) and wild-type mice. Vitamin D 0-9 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 100-107 20554701-3 2010 We have tested the ability of purified mouse 25-hydroxyvitamin D(3) 1alpha-hydroxylase (CYP27B1) to add a 1alpha-hydroxyl group to this vitamin D analog and determined whether this altered its biological activity. Vitamin D 55-64 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 88-95 21307571-4 2011 The active form of vitamin D, 1alpha,25(OH)(2)D(3), derived by vitamin D3 1alpha hydroxylase, 1alpha(OH)ase in renal proximal tubule cells is a ligand for VDR. Vitamin D 19-28 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 94-107