PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23055531-5 2012 A functional vitamin D response element was defined in the 5-prime regulatory region of the miR-498 genome, which is occupied by the vitamin D receptor and its coactivators. Vitamin D 13-22 vitamin D receptor Homo sapiens 133-151 22923289-12 2012 However, in the FF polymorphism of the VDR gene group, vitamin D supplementation may retard the higher rate of bone loss. Vitamin D 55-64 vitamin D receptor Homo sapiens 39-42 23236317-1 2012 BACKGROUND: Vitamin D can translocate a vitamin D receptor (VDR) from the nucleus to the cell membranes. Vitamin D 12-21 vitamin D receptor Homo sapiens 40-58 22612324-1 2012 BACKGROUND: Genetic polymorphisms of vitamin D receptor gene (VDR) and genes involved in vitamin D metabolism pathway, CYP27B1 and CYP24B1, may affect individual susceptibility to oral squamous cell carcinoma. Vitamin D 37-46 vitamin D receptor Homo sapiens 62-65 23111742-5 2012 It is suggested that polymorphisms and haplotypes in the VDR gene may explain the differences in response to vitamin D therapy. Vitamin D 109-118 vitamin D receptor Homo sapiens 57-60 23111742-7 2012 The Fok I, Bsm I, Apa I and Taq I polymorphisms were examined by PCR-RFLP, and 50 subjects received vitamin D therapy to evaluate the association between VDR gene polymorphisms and response to vitamin D therapy. Vitamin D 193-202 vitamin D receptor Homo sapiens 154-157 22917542-2 2012 Vitamin D exerts its effects through vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 37-55 22917542-2 2012 Vitamin D exerts its effects through vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 57-60 23236317-1 2012 BACKGROUND: Vitamin D can translocate a vitamin D receptor (VDR) from the nucleus to the cell membranes. Vitamin D 12-21 vitamin D receptor Homo sapiens 60-63 23236317-12 2012 CONCLUSION: CSE has an ability to inhibit vitamin D-induced VDR translocation, but MAPKs are not involved in this inhibition. Vitamin D 42-51 vitamin D receptor Homo sapiens 60-63 22692397-8 2012 In this article, we review the aspects related to the metabolism and immunoregulatory effects of vitamin D, VDR, and main polymorphisms involving the VDR gene and the relationship between vitamin D levels and its receptor with SLE. Vitamin D 188-197 vitamin D receptor Homo sapiens 150-153 22695798-6 2012 In addition, vitamin D (10(-10), 10(-8) and 10(-6) M) was added to sebocytes treated with vitamin D receptor (VDR) siRNA. Vitamin D 13-22 vitamin D receptor Homo sapiens 90-108 22695798-6 2012 In addition, vitamin D (10(-10), 10(-8) and 10(-6) M) was added to sebocytes treated with vitamin D receptor (VDR) siRNA. Vitamin D 13-22 vitamin D receptor Homo sapiens 110-113 22695798-10 2012 Gene expression of hCAP-18 by treatment with vitamin D was blocked in sebocytes treated with VDR siRNA. Vitamin D 45-54 vitamin D receptor Homo sapiens 93-96 22695798-11 2012 In conclusion, treatment with vitamin D resulted in increased expression of LL-37 through the vitamin D receptor of cultured sebocytes. Vitamin D 30-39 vitamin D receptor Homo sapiens 94-112 23246677-1 2012 Vitamin D receptor (VDR) is found in most tissues, not just those participating in the classic actions of vitamin D such as bone, gut, and kidney. Vitamin D 106-115 vitamin D receptor Homo sapiens 0-18 23246677-1 2012 Vitamin D receptor (VDR) is found in most tissues, not just those participating in the classic actions of vitamin D such as bone, gut, and kidney. Vitamin D 106-115 vitamin D receptor Homo sapiens 20-23 23095332-1 2012 BACKGROUND: Transcription of the cathelicidin antimicrobial peptide (CAMP) gene is induced by binding of the bioactive form of vitamin D, 1,25-dihydroxyvitamin D, to the vitamin D receptor. Vitamin D 127-136 vitamin D receptor Homo sapiens 170-188 22892281-2 2012 Most known effects of vitamin D are mediated via the vitamin D receptor (VDR). Vitamin D 22-31 vitamin D receptor Homo sapiens 53-71 22892281-2 2012 Most known effects of vitamin D are mediated via the vitamin D receptor (VDR). Vitamin D 22-31 vitamin D receptor Homo sapiens 73-76 22457088-14 2012 CONCLUSION: Vitamin D deficiency in HD patients who had not taken vitamin D receptor agonist (VDRA) is associated with an increased risk of all-cause mortality. Vitamin D 12-21 vitamin D receptor Homo sapiens 66-84 22692397-2 2012 Numerous genes have been linked to the emergence of SLE, including vitamin D receptor (VDR) gene that synthesizes the receptor of vitamin D. Vitamin D 67-76 vitamin D receptor Homo sapiens 87-90 22692397-4 2012 Vitamin D"s biological functions are mediated by VDR. Vitamin D 0-9 vitamin D receptor Homo sapiens 49-52 22664272-9 2012 Furthermore, strong VDR expression in Barrett"s mucosa may indicate an increased sensitivity of this tissue to endogenous or therapeutic effects of Vitamin D. Vitamin D 148-157 vitamin D receptor Homo sapiens 20-23 22855339-1 2012 CONTEXT: Inherited forms of vitamin D deficiency are rare causes of rickets and to date have been traced to mutations in three genes, VDR, encoding the 1alpha,25-dihydroxyvitamin D receptor, CYP27B1, encoding the vitamin D 1alpha-hydroxylase, and CYP2R1, encoding a microsomal vitamin D 25-hydroxylase. Vitamin D 28-37 vitamin D receptor Homo sapiens 134-137 23450267-1 2012 The bioactive form of vitamin D, 1alpha, 25-dihydroxyvitamin D3 (1alpha, 25(OH)2D3), is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the nuclear receptor super-family expressed in many cell types, and modulates a variety of biological functions. Vitamin D 22-31 vitamin D receptor Homo sapiens 128-146 23450267-1 2012 The bioactive form of vitamin D, 1alpha, 25-dihydroxyvitamin D3 (1alpha, 25(OH)2D3), is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the nuclear receptor super-family expressed in many cell types, and modulates a variety of biological functions. Vitamin D 22-31 vitamin D receptor Homo sapiens 148-151 22750284-3 2012 The active metabolite of the vitamin D endocrine system, 1,25-dihydroxyvitamin D (calcitriol), exerts pleiotropic effects through its interaction with the vitamin D receptor. Vitamin D 29-38 vitamin D receptor Homo sapiens 155-173 22564762-4 2012 Our results implicate PIAS4 and the process of SUMOylation as important modulators of VDR-mediated signaling which may both represent flexible mechanistic components as to how vitamin D achieves its pleiotropic effects. Vitamin D 176-185 vitamin D receptor Homo sapiens 86-89 22626544-9 2012 Identification of novel heart VIPs and their influence on VDR activity may increase our understanding of how vitamin D impacts cardiac physiology and may facilitate development of VDR/VIP drug analogs to combat heart disease. Vitamin D 109-118 vitamin D receptor Homo sapiens 58-61 22476084-1 2012 The vitamin D receptor (VDR), an evolutionarily conserved member of the nuclear receptor superfamily, links the metabolically activated vitamin D ligand, calcitriol, with its vitamin D-responsive target genes that are implicated in diverse physiological processes. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 22476084-1 2012 The vitamin D receptor (VDR), an evolutionarily conserved member of the nuclear receptor superfamily, links the metabolically activated vitamin D ligand, calcitriol, with its vitamin D-responsive target genes that are implicated in diverse physiological processes. Vitamin D 136-145 vitamin D receptor Homo sapiens 4-22 22476084-1 2012 The vitamin D receptor (VDR), an evolutionarily conserved member of the nuclear receptor superfamily, links the metabolically activated vitamin D ligand, calcitriol, with its vitamin D-responsive target genes that are implicated in diverse physiological processes. Vitamin D 136-145 vitamin D receptor Homo sapiens 24-27 22476084-5 2012 As further support that this novel interactor might be involved in vitamin D-stimulated transcriptional regulation, we demonstrate that VDR and DDX5 co-localize within the nuclei of HaCaT keratinocytes and sub-cellular protein fractions. Vitamin D 67-76 vitamin D receptor Homo sapiens 136-139 22595971-10 2012 These findings provide relevant insights into how vitamin D influences the immune system and the risk of MS through VDR interactions with the chromatin state inside MS regions. Vitamin D 50-59 vitamin D receptor Homo sapiens 116-119 22677193-12 2012 Increased expression of VDR sensitized tumor cells to the inhibitory effects of vitamin D. Vitamin D 80-89 vitamin D receptor Homo sapiens 24-27 22801440-2 2012 The active form of vitamin D interacts with its receptor the VDR that is expressed in multiple tissues and it is involved in platelets (PLTs) function. Vitamin D 19-28 vitamin D receptor Homo sapiens 61-64 22801440-9 2012 CONCLUSION: The lower VDR expression in osteoporotic could indicate a lower ability to respond to vitamin D, and could be the explanation of the increase in the PTH and decrease in the phosphorus levels in patients with respect to controls. Vitamin D 98-107 vitamin D receptor Homo sapiens 22-25 22842395-1 2012 Vitamin D plays an important role in neurodegenerative disorders as a crucial neuro-immunomodulator, and accumulating data have provided evidence for that vitamin D receptor (VDR) gene is a candidate gene for susceptibility to Parkinson"s disease (PD). Vitamin D 0-9 vitamin D receptor Homo sapiens 155-173 22842395-1 2012 Vitamin D plays an important role in neurodegenerative disorders as a crucial neuro-immunomodulator, and accumulating data have provided evidence for that vitamin D receptor (VDR) gene is a candidate gene for susceptibility to Parkinson"s disease (PD). Vitamin D 0-9 vitamin D receptor Homo sapiens 175-178 22920700-1 2012 INTRODUCTION: Vitamin D is responsible for the regulation of certain genes at the transcription level, via interaction with the vitamin D receptor, and influences host immune responses and aspects of bone development, growth, and homeostasis. Vitamin D 14-23 vitamin D receptor Homo sapiens 128-146 22404291-1 2012 Vitamin D (VD) is important for male reproduction in mammals and the VD receptor (VDR) and VD-metabolizing enzymes are expressed in human spermatozoa. Vitamin D 0-9 vitamin D receptor Homo sapiens 69-80 22879719-7 2012 In this study, we report a 7-year-old boy with reduced VDR expression in AA, recovery of whom was observed by topical application of calcipotriol, a strong vitamin D analog. Vitamin D 156-165 vitamin D receptor Homo sapiens 55-58 22710747-6 2012 One-way analysis of variance was used to examine variation in the expression levels of six genes on the vitamin D pathway-VDR, GC, CYP27A1, CYP27B1, RXRalpha, CYP24A1-and VDR protein by season, adjusted for age at diagnosis and Gleason grade. Vitamin D 104-113 vitamin D receptor Homo sapiens 122-125 22710747-6 2012 One-way analysis of variance was used to examine variation in the expression levels of six genes on the vitamin D pathway-VDR, GC, CYP27A1, CYP27B1, RXRalpha, CYP24A1-and VDR protein by season, adjusted for age at diagnosis and Gleason grade. Vitamin D 104-113 vitamin D receptor Homo sapiens 171-174 22404291-1 2012 Vitamin D (VD) is important for male reproduction in mammals and the VD receptor (VDR) and VD-metabolizing enzymes are expressed in human spermatozoa. Vitamin D 0-9 vitamin D receptor Homo sapiens 82-85 22306846-3 2012 Given that VDR is the major mediator for vitamin D"s actions, we sought to clarify the role of VDR in late-onset AD. Vitamin D 41-50 vitamin D receptor Homo sapiens 11-14 22564539-1 2012 PURPOSE: The anti-proliferative effects of 1alpha,25-dihydroxyvitamin D(3) (1,25-D(3), calcitriol, the active form of vitamin D) are mediated by the nuclear vitamin D receptor (VDR). Vitamin D 62-71 vitamin D receptor Homo sapiens 157-175 22564539-1 2012 PURPOSE: The anti-proliferative effects of 1alpha,25-dihydroxyvitamin D(3) (1,25-D(3), calcitriol, the active form of vitamin D) are mediated by the nuclear vitamin D receptor (VDR). Vitamin D 62-71 vitamin D receptor Homo sapiens 177-180 22085499-2 2012 The vitamin D receptor (VDR) is highly expressed in epithelial cells at risk for carcinogenesis including those resident in skin, breast, prostate and colon, providing a direct molecular link by which vitamin D status impacts on carcinogenesis. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 22085499-7 2012 Because VDR expression is retained in many human tumors, vitamin D status may be an important modulator of cancer progression in persons living with cancer. Vitamin D 57-66 vitamin D receptor Homo sapiens 8-11 22474172-8 2012 This VDRE served as a strong binding site for the recombinant VDR-RXRalpha heterodimers in vitro and was potently activated by VDR in the presence of vitamin D(3) in heterologous promoter assays. Vitamin D 150-159 vitamin D receptor Homo sapiens 5-8 22503810-1 2012 The vitamin D receptor (VDR) is a member of the nuclear receptor superfamily and plays a central role in the biological actions of vitamin D. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 22503810-3 2012 To understand the global function of the vitamin D system in physiopathological processes, great effort has been devoted to the detection of VDR in various tissues and cells, many of which have been identified as vitamin D targets. Vitamin D 41-50 vitamin D receptor Homo sapiens 141-144 22503810-3 2012 To understand the global function of the vitamin D system in physiopathological processes, great effort has been devoted to the detection of VDR in various tissues and cells, many of which have been identified as vitamin D targets. Vitamin D 213-222 vitamin D receptor Homo sapiens 141-144 22484315-1 2012 Vitamin D, whose levels vary seasonally with sunlight, is activated to 1alpha,25-dihydroxyvitamin D(3) that binds the vitamin D receptor (VDR) and transcriptionally regulates intestinal CYP3A4 expression. Vitamin D 0-9 vitamin D receptor Homo sapiens 118-136 22484315-1 2012 Vitamin D, whose levels vary seasonally with sunlight, is activated to 1alpha,25-dihydroxyvitamin D(3) that binds the vitamin D receptor (VDR) and transcriptionally regulates intestinal CYP3A4 expression. Vitamin D 0-9 vitamin D receptor Homo sapiens 138-141 22544453-9 2012 CONCLUSION: These results suggest that germline genetic variation in VDR, and therefore the vitamin D pathway, may mediate an association between early life sun exposure and NHL risk. Vitamin D 92-101 vitamin D receptor Homo sapiens 69-72 22576141-3 2012 An expression of the vitamin D receptor (VDR) and an anti-proliferative effect of vitamin D in melanocytes and melanoma cells have been shown in vitro. Vitamin D 21-30 vitamin D receptor Homo sapiens 41-44 22474172-8 2012 This VDRE served as a strong binding site for the recombinant VDR-RXRalpha heterodimers in vitro and was potently activated by VDR in the presence of vitamin D(3) in heterologous promoter assays. Vitamin D 150-159 vitamin D receptor Homo sapiens 62-65 22474172-11 2012 We showed that expression of the SLCO1A2 gene is induced by vitamin D(3) at the transcriptional level through the VDR. Vitamin D 60-69 vitamin D receptor Homo sapiens 114-117 22672495-4 2012 Vitamin D acts via the vitamin D receptor, a nuclear receptor, acting as an inducible transcription factor. Vitamin D 0-9 vitamin D receptor Homo sapiens 23-41 22720752-1 2012 BACKGROUND: The vitamin D3 receptor (VDR) is responsible for mediating the pleiotropic and, in part, cell-type-specific effects of 1,25-dihydroxyvitamin D3 (calcitriol) on the cardiovascular and the muscle system, on the bone development and maintenance, mineral homeostasis, cell proliferation, cell differentiation, vitamin D metabolism, and immune response modulation. Vitamin D 16-25 vitamin D receptor Homo sapiens 37-40 22681928-0 2012 Vitamin D deficiency in girls from South Brazil: a cross-sectional study on prevalence and association with vitamin D receptor gene variants. Vitamin D 0-9 vitamin D receptor Homo sapiens 108-126 22681928-3 2012 We determined the prevalence of vitamin D deficiency in girls from South Brazil and investigated whether the genotypic distribution of the BsmI, ApaI and TaqI polymorphisms of the VDR gene and their haplotypes were associated with vitamin D levels. Vitamin D 231-240 vitamin D receptor Homo sapiens 180-183 22681928-14 2012 The BsmI, ApaI and TaqI wild variants of the VDR gene, as well as the GGT haplotype, were associated with lower vitamin D levels, suggesting that VDR gene polymorphisms could be linked to higher susceptibility to vitamin D deficiency in a sub-population of children and adolescents. Vitamin D 112-121 vitamin D receptor Homo sapiens 45-48 22681928-14 2012 The BsmI, ApaI and TaqI wild variants of the VDR gene, as well as the GGT haplotype, were associated with lower vitamin D levels, suggesting that VDR gene polymorphisms could be linked to higher susceptibility to vitamin D deficiency in a sub-population of children and adolescents. Vitamin D 112-121 vitamin D receptor Homo sapiens 146-149 22681928-14 2012 The BsmI, ApaI and TaqI wild variants of the VDR gene, as well as the GGT haplotype, were associated with lower vitamin D levels, suggesting that VDR gene polymorphisms could be linked to higher susceptibility to vitamin D deficiency in a sub-population of children and adolescents. Vitamin D 213-222 vitamin D receptor Homo sapiens 45-48 22414425-6 2012 In keratinocyte cell cultures, the ligand-conjugated liposomes loaded with the vitamin D(3) analogue calcipotriol induced transcription of the gene encoding the antimicrobial peptide cathelicidin, which is activated through the vitamin D(3) receptor upon binding of vitamin D(3) analogues. Vitamin D 79-88 vitamin D receptor Homo sapiens 228-249 22304841-0 2012 Vitamin D and insulin sensitivity: can gene association and pharmacogenetic studies of the vitamin D receptor provide clarity? Vitamin D 0-9 vitamin D receptor Homo sapiens 91-109 22563729-2 2012 The receptor is activated by vitamin D analogues that induce the disruption of VDR-corepressor binding and promote VDR-coactivator interactions. Vitamin D 29-38 vitamin D receptor Homo sapiens 79-82 22676419-6 2012 Most of vitamin D biological actions are mediated by the vitamin D receptor and the synthesis and catabolism of this hormone are regulated by the enzymes CYP27B1 and CYP24A1. Vitamin D 8-17 vitamin D receptor Homo sapiens 57-75 22563729-2 2012 The receptor is activated by vitamin D analogues that induce the disruption of VDR-corepressor binding and promote VDR-coactivator interactions. Vitamin D 29-38 vitamin D receptor Homo sapiens 115-118 26889405-6 2012 VDR activation using newer agents including vitamin D mimetics (such as paricalcitol and maxacalcitol) are promising agents, which may be related to their selectivity in activating VDR by means of attracting different post-D-complex cofactors. Vitamin D 44-53 vitamin D receptor Homo sapiens 0-3 22328083-2 2012 The active vitamin D metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) regulates gene transcription via its nuclear receptor (VDR), and posttranscriptional regulatory mechanisms of gene expression have also been proposed. Vitamin D 11-20 vitamin D receptor Homo sapiens 137-140 22275473-5 2012 RESULTS AND DISCUSSION: The vitamin D receptor (VDR) and vitamin D metabolizing enzymes are found in reproductive tissues of women and men. Vitamin D 28-37 vitamin D receptor Homo sapiens 48-51 22322599-5 2012 The protective effects of 1,25-(OH)(2)D(3) against thymine dimers were abolished in fibroblasts from patients with hereditary vitamin D-resistant rickets that expressed no VDR protein, indicating that the VDR is essential for photoprotection. Vitamin D 126-135 vitamin D receptor Homo sapiens 205-208 22322599-6 2012 Photoprotection remained in hereditary vitamin D-resistant rickets fibroblasts expressing a VDR with a defective DNA-binding domain or a mutation in helix H1 of the classical ligand-binding domain, both defects resulting in a failure to mediate genomic responses, implicating nongenomic responses for photoprotection. Vitamin D 39-48 vitamin D receptor Homo sapiens 92-95 22532985-2 2012 Some genetic factors that may contribute to asthma are regulated by vitamin D, such as vitamin D receptor (VDR), human leukocyte antigen genes (HLA), human Toll-like receptors (TLR), matrix metalloproteinases (MMPs), a disintegrin and metalloprotein-33 (ADAM-33), and poly(ADP-ribosyl) polymerase- 1 (PARP-1). Vitamin D 68-77 vitamin D receptor Homo sapiens 87-105 22532985-2 2012 Some genetic factors that may contribute to asthma are regulated by vitamin D, such as vitamin D receptor (VDR), human leukocyte antigen genes (HLA), human Toll-like receptors (TLR), matrix metalloproteinases (MMPs), a disintegrin and metalloprotein-33 (ADAM-33), and poly(ADP-ribosyl) polymerase- 1 (PARP-1). Vitamin D 68-77 vitamin D receptor Homo sapiens 107-110 22449247-1 2012 INTRODUCTION: In the past years, the biologically active form of vitamin D(3), 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), has received large appreciation due to the broad physiological impact of the hormone and its nuclear receptor, the transcription factor vitamin D receptor (VDR). Vitamin D 65-74 vitamin D receptor Homo sapiens 271-289 22449247-1 2012 INTRODUCTION: In the past years, the biologically active form of vitamin D(3), 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), has received large appreciation due to the broad physiological impact of the hormone and its nuclear receptor, the transcription factor vitamin D receptor (VDR). Vitamin D 65-74 vitamin D receptor Homo sapiens 291-294 23814529-2 2012 Vitamin D receptor (VDR), a nuclear receptor, mediates the biological functions of vitamin D. Vitamin D 83-92 vitamin D receptor Homo sapiens 0-18 23814529-2 2012 Vitamin D receptor (VDR), a nuclear receptor, mediates the biological functions of vitamin D. Vitamin D 83-92 vitamin D receptor Homo sapiens 20-23 26889405-6 2012 VDR activation using newer agents including vitamin D mimetics (such as paricalcitol and maxacalcitol) are promising agents, which may be related to their selectivity in activating VDR by means of attracting different post-D-complex cofactors. Vitamin D 44-53 vitamin D receptor Homo sapiens 181-184 21871642-1 2012 The objectives of the study were to determine associations between single nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) gene and insulin resistance and the effects of these SNPs on changes in insulin sensitivity in response to vitamin D supplementation. Vitamin D 113-122 vitamin D receptor Homo sapiens 133-136 21871642-9 2012 This study has highlighted the association of vitamin D responsiveness and insulin resistance with VDR gene polymorphisms. Vitamin D 46-55 vitamin D receptor Homo sapiens 99-102 21871642-11 2012 Genotyping of the VDR gene may provide a predictive measure for insulin resistance in response to vitamin D intervention. Vitamin D 98-107 vitamin D receptor Homo sapiens 18-21 22193171-1 2012 The anticarcinogenic potential of vitamin D might be mediated by not only calcium metabolism but also other mechanisms initiated by vitamin D receptor (VDR). Vitamin D 34-43 vitamin D receptor Homo sapiens 132-150 21947233-10 2012 Association between VDR polymorphisms and UTI is in accordance with the understanding of how vitamin D modulates the immune response against infections. Vitamin D 93-102 vitamin D receptor Homo sapiens 20-23 22193171-1 2012 The anticarcinogenic potential of vitamin D might be mediated by not only calcium metabolism but also other mechanisms initiated by vitamin D receptor (VDR). Vitamin D 34-43 vitamin D receptor Homo sapiens 152-155 22213316-1 2012 The transcription factor vitamin D receptor (VDR) is the nuclear sensor for the biologically most active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)). Vitamin D 25-34 vitamin D receptor Homo sapiens 45-48 22138541-7 2012 Thyroid hormone receptor (THR) and vitamin D receptor (VDR) pathways were also regulated in normal and disease endometrium by activation of TH or vitamin D regulated genes. Vitamin D 35-44 vitamin D receptor Homo sapiens 55-58 22179700-1 2012 Transcription regulation by steroid hormones and other metabolites is mediated by nuclear receptors (NRs) such as the vitamin D and retinoid X receptors (VDR and RXR). Vitamin D 118-127 vitamin D receptor Homo sapiens 154-157 21931993-1 2012 Vitamin D exerts its activity through binding to the high-affinity nuclear vitamin D receptor (VDR), and majority of genetic studies have primarily focused on variation within this gene. Vitamin D 0-9 vitamin D receptor Homo sapiens 75-93 21931993-1 2012 Vitamin D exerts its activity through binding to the high-affinity nuclear vitamin D receptor (VDR), and majority of genetic studies have primarily focused on variation within this gene. Vitamin D 0-9 vitamin D receptor Homo sapiens 95-98 21931993-2 2012 Therefore, analysis of genetic variation in VDR genes may provide insight into the role of vitamin D in renal cell carcinoma (RCC) etiology in our study population. Vitamin D 91-100 vitamin D receptor Homo sapiens 44-47 22300961-10 2012 Analysing combined effects, a significant impact of low 25-OH vitamin D levels on sustained virological response were only seen in patients with the unfavourable NR1I1 CCA (bAt) haplotype (OR for non-SVR 3.55; 95% CI 1.005, 12.57; P=0.049). Vitamin D 62-71 vitamin D receptor Homo sapiens 162-167 22213318-1 2012 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D [1alpha,25(OH)(2)D], interacts with vitamin D receptor (VDR) and induces antiproliferative, anti-invasive, proapoptotic and pro-differentiation activities in prostate cancer cells. Vitamin D 19-28 vitamin D receptor Homo sapiens 95-113 22213325-3 2012 1,25-Dihydroxyvitamin D (1,25(OH)(2)D(3)) is the active form of vitamin D and exerts its actions via a specific intracellular vitamin D receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 126-144 22213318-1 2012 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D [1alpha,25(OH)(2)D], interacts with vitamin D receptor (VDR) and induces antiproliferative, anti-invasive, proapoptotic and pro-differentiation activities in prostate cancer cells. Vitamin D 19-28 vitamin D receptor Homo sapiens 115-118 22213325-3 2012 1,25-Dihydroxyvitamin D (1,25(OH)(2)D(3)) is the active form of vitamin D and exerts its actions via a specific intracellular vitamin D receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 146-149 22213321-1 2012 The Delta(16) structure as a vitamin D analog enhanced vitamin D receptor (VDR) binding affinity and induced significant cell differentiation, whereas its relative calcemic activity was reduced compared to 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)). Vitamin D 29-38 vitamin D receptor Homo sapiens 55-73 22213328-3 2012 The antiproliferative effects of calcitriol [1,25(OH)(2)D(3)] mediated via the vitamin D receptor (VDR) render vitamin D a promising target in breast cancer therapy. Vitamin D 79-88 vitamin D receptor Homo sapiens 99-102 22213321-1 2012 The Delta(16) structure as a vitamin D analog enhanced vitamin D receptor (VDR) binding affinity and induced significant cell differentiation, whereas its relative calcemic activity was reduced compared to 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)). Vitamin D 29-38 vitamin D receptor Homo sapiens 75-78 22213323-1 2012 BACKGROUND: Vitamin D receptor (VDR) polymorphisms have important implications for vitamin D signalling and are associated with various malignancies. Vitamin D 83-92 vitamin D receptor Homo sapiens 12-30 22213323-1 2012 BACKGROUND: Vitamin D receptor (VDR) polymorphisms have important implications for vitamin D signalling and are associated with various malignancies. Vitamin D 83-92 vitamin D receptor Homo sapiens 32-35 22213323-7 2012 Comparison of the frequencies of the VDR genotypes in sunlight-exposed vs. not sunlight-exposed skin areas revealed BB 30.1% vs. 7.1% respectively in BCCs and BB 28.1% vs. 0.0% respectively in SCCs, indicating that vitamin D signalling may be of importance for photocarcinogenesis of the skin. Vitamin D 215-224 vitamin D receptor Homo sapiens 37-40 22242854-3 2012 The crystal structure of the VDR and detailed knowledge on its molecular interactions with the ligand provide significant insight into the mechanisms of vitamin D signaling. Vitamin D 153-162 vitamin D receptor Homo sapiens 29-32 22466564-1 2012 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds to the vitamin D receptor (VDR) and regulates various physiological and pharmacological processes. Vitamin D 19-28 vitamin D receptor Homo sapiens 94-112 22466564-1 2012 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds to the vitamin D receptor (VDR) and regulates various physiological and pharmacological processes. Vitamin D 19-28 vitamin D receptor Homo sapiens 114-117 21755299-1 2012 BACKGROUND: Vitamin D, which exerts its effect through vitamin D receptor (VDR), and LL-37, a vitamin D-dependent antimicrobial peptide, are involved in many infectious diseases. Vitamin D 12-21 vitamin D receptor Homo sapiens 55-73 22738935-3 2012 Vitamin D has both stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells. Vitamin D 0-9 vitamin D receptor Homo sapiens 98-116 22738935-3 2012 Vitamin D has both stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells. Vitamin D 0-9 vitamin D receptor Homo sapiens 118-121 21755299-1 2012 BACKGROUND: Vitamin D, which exerts its effect through vitamin D receptor (VDR), and LL-37, a vitamin D-dependent antimicrobial peptide, are involved in many infectious diseases. Vitamin D 12-21 vitamin D receptor Homo sapiens 75-78 21755299-1 2012 BACKGROUND: Vitamin D, which exerts its effect through vitamin D receptor (VDR), and LL-37, a vitamin D-dependent antimicrobial peptide, are involved in many infectious diseases. Vitamin D 55-64 vitamin D receptor Homo sapiens 75-78 23548800-2 2012 Vitamin D through its receptor, VDR, provides renal protection in diabetic nephropathy, but limited data exist about its effect on podocytes. Vitamin D 0-9 vitamin D receptor Homo sapiens 32-35 22988423-6 2012 The potential role of vitamin D deficiency in insulin resistance has been proposed to be associated with inherited gene polymorphisms including vitamin D-binding protein, vitamin D receptor, and vitamin D 1 alpha-hydroxylase gene. Vitamin D 22-31 vitamin D receptor Homo sapiens 171-189 22108803-3 2012 VDR and RXR colocalized to predominantly promoter distal, vitamin D response element-containing sites in a largely ligand-dependent manner. Vitamin D 58-67 vitamin D receptor Homo sapiens 0-3 22785457-4 2012 In addition, genome-wide association studies and candidate gene studies have revealed that several vitamin D-related genes, including VDR, GC, NADSYN1, CYP2R1, CYP24A1, CYP27B1, and C10orf88 contribute to variations in serum 25(OH)D levels. Vitamin D 99-108 vitamin D receptor Homo sapiens 134-137 22785457-9 2012 Although this is a small study, our findings suggest that VDR, NADSYN1, and GC polymorphisms may be linked to the manifestation of vitamin D deficiency in Japanese children. Vitamin D 131-140 vitamin D receptor Homo sapiens 58-61 22001128-9 2012 The cancer protection often associated with high-normal vitamin D status may be attributable, in part, to the ability of the activated vitamin D receptor to decrease cox-2 expression while promoting PGE2 catabolism and suppressing the expression of PGE2 receptors. Vitamin D 56-65 vitamin D receptor Homo sapiens 135-153 23304521-2 2012 Vitamin D is considered to have anticancer properties, currently thought to work mainly through its nuclear receptor or vitamin D receptor. Vitamin D 0-9 vitamin D receptor Homo sapiens 120-138 23166493-2 2012 We report here that TLR8 activation in human macrophages induces the expression of the human cathelicidin microbial peptide (CAMP), the vitamin D receptor (VDR) and cytochrome P450, family 27, subfamily B, polypeptide 1 (CYP27B1), which 1alpha-hydroxylates the inactive form of vitamin D, 25-hydroxycholecalciferol, into its biologically active metabolite. Vitamin D 136-145 vitamin D receptor Homo sapiens 156-159 21693169-1 2011 Hereditary Vitamin D Resistant Rickets (HVDRR) is a rare disease caused by mutations in the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 92-110 22871095-2 2012 Pancreatic tissues express the vitamin D receptor (VDR) and vitamin D-binding protein; some allelic variations in genes involved in vitamin D metabolism and VDR are associated with glucose intolerance, defective insulin secretion, and sensitivity. Vitamin D 31-40 vitamin D receptor Homo sapiens 51-54 22871095-2 2012 Pancreatic tissues express the vitamin D receptor (VDR) and vitamin D-binding protein; some allelic variations in genes involved in vitamin D metabolism and VDR are associated with glucose intolerance, defective insulin secretion, and sensitivity. Vitamin D 31-40 vitamin D receptor Homo sapiens 157-160 22536764-3 2012 The active vitamin D metabolite, 1,25-dihydroxyvitamin D (1,25(OH)(2)D) binds to the vitamin D receptor (VDR) in the intestinal cell and stimulates the active calcium transport from the intestine to the circulation. Vitamin D 11-20 vitamin D receptor Homo sapiens 85-103 22536764-3 2012 The active vitamin D metabolite, 1,25-dihydroxyvitamin D (1,25(OH)(2)D) binds to the vitamin D receptor (VDR) in the intestinal cell and stimulates the active calcium transport from the intestine to the circulation. Vitamin D 11-20 vitamin D receptor Homo sapiens 105-108 22536764-7 2012 Both calcium and vitamin D metabolites can decrease the secretion of parathyroid hormone (PTH) through the calcium sensing receptor and the VDR respectively. Vitamin D 17-26 vitamin D receptor Homo sapiens 140-143 22536770-2 2012 The vitamin D receptor (VDR) is highly expressed in epithelial cells at risk for carcinogenesis including those resident in skin, breast, prostate and colon, providing a direct molecular link by which vitamin D status impacts on carcinogenesis. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 22536770-7 2012 Because VDR expression is retained in many human tumors, vitamin D status may be an important modulator of cancer progression in persons living with cancer. Vitamin D 57-66 vitamin D receptor Homo sapiens 8-11 22000399-4 2011 Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR). Vitamin D 69-78 vitamin D receptor Homo sapiens 139-157 22000399-4 2011 Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR). Vitamin D 69-78 vitamin D receptor Homo sapiens 159-162 21664236-1 2011 The keratinocytes of the skin are unique in being not only the primary source of vitamin D for the body, but in possessing the enzymatic machinery to metabolize vitamin D to its active metabolite 1,25(OH)(2)D. Furthermore, these cells also express the vitamin D receptor (VDR) that enables them to respond to the 1,25(OH)(2)D they produce. Vitamin D 161-170 vitamin D receptor Homo sapiens 252-270 21664236-1 2011 The keratinocytes of the skin are unique in being not only the primary source of vitamin D for the body, but in possessing the enzymatic machinery to metabolize vitamin D to its active metabolite 1,25(OH)(2)D. Furthermore, these cells also express the vitamin D receptor (VDR) that enables them to respond to the 1,25(OH)(2)D they produce. Vitamin D 161-170 vitamin D receptor Homo sapiens 272-275 21664245-1 2011 The purpose of this article is to review the activation of signal transduction pathways in skeletal muscle cells by the hormone 1alpha,25(OH)(2)-vitamin D(3) [1alpha,25(OH)(2)D(3)], focusing on the role of the vitamin D receptor (VDR). Vitamin D 145-154 vitamin D receptor Homo sapiens 210-228 21664245-1 2011 The purpose of this article is to review the activation of signal transduction pathways in skeletal muscle cells by the hormone 1alpha,25(OH)(2)-vitamin D(3) [1alpha,25(OH)(2)D(3)], focusing on the role of the vitamin D receptor (VDR). Vitamin D 145-154 vitamin D receptor Homo sapiens 230-233 22066785-2 2011 This carborane-based VDR ligand exhibited moderate vitamin D activity, comparable to that of the natural hormone, despite its simple and flexible structure. Vitamin D 51-60 vitamin D receptor Homo sapiens 21-24 21693169-1 2011 Hereditary Vitamin D Resistant Rickets (HVDRR) is a rare disease caused by mutations in the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 41-44 21664249-5 2011 The anti-proliferative and pro-differentiating properties of vitamin D have been attributed to calcitriol [1,25(OH)(2)D(3)], the hormonally active form of vitamin D, acting through the vitamin D receptor (VDR). Vitamin D 61-70 vitamin D receptor Homo sapiens 185-203 21801808-5 2011 Conversely, any situation that impairs the efficiency of the 1,25-(OH)(2)D(3)/VDR signaling system at the level of the gut mucosa, e.g. vitamin D insufficiency, may increase risk for the development of IBD and colorectal cancer. Vitamin D 136-145 vitamin D receptor Homo sapiens 78-81 21664249-5 2011 The anti-proliferative and pro-differentiating properties of vitamin D have been attributed to calcitriol [1,25(OH)(2)D(3)], the hormonally active form of vitamin D, acting through the vitamin D receptor (VDR). Vitamin D 61-70 vitamin D receptor Homo sapiens 205-208 21664249-5 2011 The anti-proliferative and pro-differentiating properties of vitamin D have been attributed to calcitriol [1,25(OH)(2)D(3)], the hormonally active form of vitamin D, acting through the vitamin D receptor (VDR). Vitamin D 155-164 vitamin D receptor Homo sapiens 185-203 21664249-5 2011 The anti-proliferative and pro-differentiating properties of vitamin D have been attributed to calcitriol [1,25(OH)(2)D(3)], the hormonally active form of vitamin D, acting through the vitamin D receptor (VDR). Vitamin D 155-164 vitamin D receptor Homo sapiens 205-208 21612999-3 2011 Vitamin D effects are mediated through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 43-61 22018918-10 2011 The in vitro tests indicated that, compared to the analogue 7, unsubstituted at C-13, the synthesized vitamin D analogue 10 showed markedly improved VDR binding ability, significantly enhanced HL-60 differentiation activity as well as increased transcriptional potency. Vitamin D 102-111 vitamin D receptor Homo sapiens 149-152 21612999-3 2011 Vitamin D effects are mediated through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 63-66 21764620-12 2011 CONCLUSION: The rate of vitamin D deficiency was high in our T2D patients, and was associated with the VDR gene FokI and ApaI polymorphisms and cardiovascular risk profile. Vitamin D 24-33 vitamin D receptor Homo sapiens 103-106 21764620-13 2011 Measurements of vitamin D may help to detect T2D patients with cardiovascular risk, and VDR polymorphisms might explain why vitamin D deficiency is so frequently seen in some T2D patients. Vitamin D 124-133 vitamin D receptor Homo sapiens 88-91 21963453-1 2011 Previous research has shown that vitamin D could suppress proliferation, migration and invasion of cancers, but the effects of vitamin D may be related to the expression of Snail-1, which could inhibit the expression of the vitamin-D gene receptor (VDR). Vitamin D 127-136 vitamin D receptor Homo sapiens 224-247 22017388-4 2011 Vitamin D receptor activators, such as paricalcitol and doxercalciferol, with fewer calcemic and phosphatemic effects, have also been introduced to control parathormone production and the interest in native vitamin D supplementation has grown. Vitamin D 207-216 vitamin D receptor Homo sapiens 0-18 21917910-1 2011 The vitamin D receptor (VDR) mediates vitamin D signaling in numerous physiological and pharmacological processes, including bone and calcium metabolism, cellular growth and differentiation, immunity, and cardiovascular function. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 21963453-1 2011 Previous research has shown that vitamin D could suppress proliferation, migration and invasion of cancers, but the effects of vitamin D may be related to the expression of Snail-1, which could inhibit the expression of the vitamin-D gene receptor (VDR). Vitamin D 127-136 vitamin D receptor Homo sapiens 249-252 21947295-2 2011 Using Cre-Lox technology we have selectively deleted the vitamin D receptor (VDR) gene in the cardiac myocyte in an effort to better understand the role of vitamin D in regulating myocyte structure and function. Vitamin D 57-66 vitamin D receptor Homo sapiens 77-80 21803404-12 2011 CONCLUSION: Our results demonstrate how structural optimization of the vitamin-D scaffold leads to identification of a non-hypercalcemic compound MT19c which exerts cytotoxicity in vitro based on a VDR-independent signaling pathway and displays potent anti-cancer activity in ovarian cancer cell models. Vitamin D 71-80 vitamin D receptor Homo sapiens 198-201 22218438-1 2011 The vitamin D endocrine system comprises a group of 7-dehydrocholesterol-derived secosteroid molecules, including its active metabolite 1,25-dihydroxy-vitamin D (1,25(OH)(2)D), its precursors and other metabolites, its binding protein (DBP) and nuclear receptor (VDR), as well as cytochrome P450 complex enzymes participating in activation and inactivation pathways of those molecules. Vitamin D 4-13 vitamin D receptor Homo sapiens 263-266 22011638-1 2011 Vitamin D is essential not only for calcium and bone metabolism, but it also may exert other biological activities, including immunomodulation through the expression of vitamin D receptor in antigen-presenting cells and activated T cells. Vitamin D 0-9 vitamin D receptor Homo sapiens 169-187 21812032-0 2011 Hereditary vitamin D-resistant rickets (HVDRR) owing to a heterozygous mutation in the vitamin D receptor. Vitamin D 11-20 vitamin D receptor Homo sapiens 87-105 21812032-1 2011 Hereditary vitamin D-resistant rickets (HVDRR) is a rare autosomal recessive disease caused by mutations in the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 112-130 21812032-1 2011 Hereditary vitamin D-resistant rickets (HVDRR) is a rare autosomal recessive disease caused by mutations in the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 41-44 22155603-9 2011 Based on the relationship between ultraviolet irradiance and vitamin D production, we employed a candidate gene approach for evaluating common variation in key vitamin D pathway genes (the genes encoding the vitamin D receptor [VDR]; cytochrome P450, family 27, subfamily B, polypeptide 1 [CYP27B1]; cytochrome P450, family 24, subfamily A, polypeptide 1 [CYP24A1]; and CYP27A1) in this same family-based cohort. Vitamin D 160-169 vitamin D receptor Homo sapiens 208-226 21868377-11 2011 We conclude that Dex increases VDR and vitamin D effects by increasing Vdr de novo transcription in a GR-dependent manner. Vitamin D 39-48 vitamin D receptor Homo sapiens 71-74 22155603-9 2011 Based on the relationship between ultraviolet irradiance and vitamin D production, we employed a candidate gene approach for evaluating common variation in key vitamin D pathway genes (the genes encoding the vitamin D receptor [VDR]; cytochrome P450, family 27, subfamily B, polypeptide 1 [CYP27B1]; cytochrome P450, family 24, subfamily A, polypeptide 1 [CYP24A1]; and CYP27A1) in this same family-based cohort. Vitamin D 160-169 vitamin D receptor Homo sapiens 228-231 21529994-1 2011 The vitamin D metabolite, 1,25-(OH)2D3, binds the vitamin D receptor (VDR) to exert its regulatory effects at the transcription level. Vitamin D 4-13 vitamin D receptor Homo sapiens 50-68 22125685-1 2011 Growing evidence suggests an elevated risk for colorectal neoplasia among individuals with low levels of vitamin D, the biological actions of which are mediated by the vitamin D receptor (VDR). Vitamin D 105-114 vitamin D receptor Homo sapiens 168-186 22125685-1 2011 Growing evidence suggests an elevated risk for colorectal neoplasia among individuals with low levels of vitamin D, the biological actions of which are mediated by the vitamin D receptor (VDR). Vitamin D 105-114 vitamin D receptor Homo sapiens 188-191 22194708-2 2011 The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and may be influenced by polymorphism in the VDR gene. Vitamin D 15-24 vitamin D receptor Homo sapiens 61-79 22194708-2 2011 The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and may be influenced by polymorphism in the VDR gene. Vitamin D 15-24 vitamin D receptor Homo sapiens 81-84 22194708-2 2011 The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and may be influenced by polymorphism in the VDR gene. Vitamin D 15-24 vitamin D receptor Homo sapiens 131-134 21832078-6 2011 Finally and paradoxically, ER stress instead suppresses the 1,25(OH)(2) vitamin D(3)-induced activation of VDR, but blockade of VDR activity does not alter ER stress-induced CAMP up-regulation. Vitamin D 72-81 vitamin D receptor Homo sapiens 107-110 21715350-2 2011 The authors also determined if corneas contain mRNA for the vitamin D receptor (VDR) and 1alpha-hydroxylase, the enzyme required to convert 25(OH)D(3) to 1,25(OH)(2)D(3), and measured vitamin D metabolite concentrations in aqueous and vitreous humor. Vitamin D 60-69 vitamin D receptor Homo sapiens 80-83 21529994-1 2011 The vitamin D metabolite, 1,25-(OH)2D3, binds the vitamin D receptor (VDR) to exert its regulatory effects at the transcription level. Vitamin D 4-13 vitamin D receptor Homo sapiens 70-73 25018911-6 2011 Therefore, compounds that selectively activate vitamin D receptors (VDR activators), potentially reducing Ca-P toxicity and distinctly affecting pathogenic mechanisms of VC, might enhance CV and renal protection, increase the vitamin D therapeutic window, and thus provide a significant clinical benefit. Vitamin D 47-56 vitamin D receptor Homo sapiens 68-71 25018912-3 2011 The link between vitamin D deficiency and death is a defective activation of the vitamin D receptor (VDR) by 1,25-dihydroxyvitamin D (calcitriol, the vitamin D hormone) to induce/repress genes that maintain mineral homeostasis and skeletal integrity, and prevent secondary hyperparathyroidism, hypertension, immune disorders, and renal and cardiovascular (CV) damage. Vitamin D 17-26 vitamin D receptor Homo sapiens 81-99 25018912-3 2011 The link between vitamin D deficiency and death is a defective activation of the vitamin D receptor (VDR) by 1,25-dihydroxyvitamin D (calcitriol, the vitamin D hormone) to induce/repress genes that maintain mineral homeostasis and skeletal integrity, and prevent secondary hyperparathyroidism, hypertension, immune disorders, and renal and cardiovascular (CV) damage. Vitamin D 17-26 vitamin D receptor Homo sapiens 101-104 21941510-10 2011 Understanding the molecular epigenetic mechanism of vitamin D/VDR would provide rationale for dietary vitamin D-mediated intervention in prevention and management of chronic lung diseases linked with vitamin D deficiency. Vitamin D 102-111 vitamin D receptor Homo sapiens 62-65 21941510-10 2011 Understanding the molecular epigenetic mechanism of vitamin D/VDR would provide rationale for dietary vitamin D-mediated intervention in prevention and management of chronic lung diseases linked with vitamin D deficiency. Vitamin D 102-111 vitamin D receptor Homo sapiens 62-65 21941510-8 2011 Active metabolite of vitamin D, 1,25-dihydroxyvitamin D(3) plays an essential role in cellular metabolism and differentiation via its nuclear receptor (VDR) that cooperates with several other chromatin modification enzymes (histone acetyltransferases and histone deacetylases), thereby mediating complex epigenetic events in vitamin D signaling and metabolism. Vitamin D 21-30 vitamin D receptor Homo sapiens 152-155 21696575-2 2011 This study was designed to evaluate the possible role of VDR single nucleotide polymorphisms (SNPs) on different aspects of diabetic host response (anthropometric, metabolic, oxidative stress and inflammatory) to daily intake of vitamin D through fortified yogurt drink for 12 weeks. Vitamin D 229-238 vitamin D receptor Homo sapiens 57-60 21941510-8 2011 Active metabolite of vitamin D, 1,25-dihydroxyvitamin D(3) plays an essential role in cellular metabolism and differentiation via its nuclear receptor (VDR) that cooperates with several other chromatin modification enzymes (histone acetyltransferases and histone deacetylases), thereby mediating complex epigenetic events in vitamin D signaling and metabolism. Vitamin D 46-55 vitamin D receptor Homo sapiens 152-155 21872797-3 2011 When occupied by 1alpha,25(OH)2D3, the VDR-GP interacts with the retinoid X receptor to form a heterodimer that binds to vitamin D responsive elements in the region of genes directly controlled by 1alpha,25(OH)2D3. Vitamin D 121-130 vitamin D receptor Homo sapiens 39-42 21872797-4 2011 By recruiting complexes of either coactivators or corepressors, activated VDR modulates the transcription of genes encoding proteins that promulgate the traditional genomic functions of vitamin D, including signaling intestinal calcium and phosphate absorption to effect skeletal and calcium homeostasis. Vitamin D 186-195 vitamin D receptor Homo sapiens 74-77 21872809-1 2011 Vitamin D is a precursor for a secosteroid ligand of a major transcription factor, VDR, and is vital for normal bone mineralization. Vitamin D 0-9 vitamin D receptor Homo sapiens 83-86 21592821-1 2011 Calcitriol, the hormonal form of vitamin D(3), exerts immunomodulatory effects through the vitamin D(3) receptor (VDR) and increases prolactin (PRL) expression in the pituitary and decidua. Vitamin D 33-42 vitamin D receptor Homo sapiens 91-112 21592821-1 2011 Calcitriol, the hormonal form of vitamin D(3), exerts immunomodulatory effects through the vitamin D(3) receptor (VDR) and increases prolactin (PRL) expression in the pituitary and decidua. Vitamin D 33-42 vitamin D receptor Homo sapiens 114-117 21424181-1 2011 Hereditary vitamin D-resistant rickets (HVDRR), an autosomal recessive disorder caused by inactivating mutations in the vitamin D receptor (VDR) gene. Vitamin D 11-20 vitamin D receptor Homo sapiens 120-138 21424181-1 2011 Hereditary vitamin D-resistant rickets (HVDRR), an autosomal recessive disorder caused by inactivating mutations in the vitamin D receptor (VDR) gene. Vitamin D 11-20 vitamin D receptor Homo sapiens 41-44 21860566-1 2011 Hereditary vitamin D resistant rickets (HVDRR) is a rare genetic disorder caused by a mutation of vitamin D receptor (VDR) gene. Vitamin D 11-20 vitamin D receptor Homo sapiens 98-116 21860566-1 2011 Hereditary vitamin D resistant rickets (HVDRR) is a rare genetic disorder caused by a mutation of vitamin D receptor (VDR) gene. Vitamin D 11-20 vitamin D receptor Homo sapiens 41-44 21696575-11 2011 If VDR polymorphisms are found to influence the response to our intervention, then knowing distribution of VDR polymorphisms in both diabetic and non-diabetic populations can give a picture of the proportion of the community in whom up to 1000 IU/d vitamin D may not be effective enough to improve insulin resistance and related morbidities. Vitamin D 249-258 vitamin D receptor Homo sapiens 107-110 21673104-1 2011 In recent years, vitamin D has received increased attention due to the resurgence of vitamin D deficiency and rickets in developed countries together with the identification of extraskeletal vitamin D receptor-mediated actions, suggesting unexpected benefits of vitamin D in health and diseases. Vitamin D 17-26 vitamin D receptor Homo sapiens 191-209 21521263-2 2011 Vitamin D interacts with the vitamin D receptor (VDR) to negatively regulate renin expression in mice; however, human studies linking genetic variation in the VDR with renin are lacking. Vitamin D 0-9 vitamin D receptor Homo sapiens 159-162 21537045-9 2011 CONCLUSION: High VDR expression in prostate tumors is associated with a reduced risk of lethal cancer, suggesting a role of the vitamin D pathway in prostate cancer progression. Vitamin D 128-137 vitamin D receptor Homo sapiens 17-20 20668935-2 2011 Effects of vitamin D are not only mediated via the vitamin D receptors by active vitamin D metabolites, but 25(OH)D(3) also acts through VDR-independent pathways directly. Vitamin D 11-20 vitamin D receptor Homo sapiens 137-140 21561543-1 2011 Paricalcitol is a synthetic vitamin D analogue acting on vitamin D receptor (VDR). Vitamin D 28-37 vitamin D receptor Homo sapiens 57-75 21561543-1 2011 Paricalcitol is a synthetic vitamin D analogue acting on vitamin D receptor (VDR). Vitamin D 28-37 vitamin D receptor Homo sapiens 77-80 21378269-10 2011 CONCLUSIONS: These meta-analyses support the evidence of an inverse association between vitamin D intake, 25-hydroxyvitamin D status, and the BsmI VDR polymorphism and CRC risk. Vitamin D 88-97 vitamin D receptor Homo sapiens 147-150 21348760-8 2011 In this review, we will mainly focus on: (1) the application of genomic technologies for the identification and validation of molecular targets for chemoprevention; (2) the role of vitamin D and its cognate receptor VDR (vitamin D receptor) as a model for the molecularly targeted chemoprevention of breast cancer. Vitamin D 181-190 vitamin D receptor Homo sapiens 216-219 21348760-8 2011 In this review, we will mainly focus on: (1) the application of genomic technologies for the identification and validation of molecular targets for chemoprevention; (2) the role of vitamin D and its cognate receptor VDR (vitamin D receptor) as a model for the molecularly targeted chemoprevention of breast cancer. Vitamin D 181-190 vitamin D receptor Homo sapiens 221-239 21427118-1 2011 BACKGROUND: The vitamin D receptor (VDR) is expressed in human spermatozoa, and VDR-knockout mice and vitamin D (VD) deficiency in rodents results in impaired fertility, low sperm counts and a low number of motile spermatozoa. Vitamin D 16-25 vitamin D receptor Homo sapiens 36-39 21623580-1 2011 The widely differing functions of vitamin D are based both on a wide diffusion of its specific receptor (VDR) and on the ability of many cells, in addition to renal tubular cells, to synthesize calcitriol for autocrine and paracrine functions. Vitamin D 34-43 vitamin D receptor Homo sapiens 105-108 21278761-2 2011 Vitamin D mediates its effect though binding to vitamin D receptor (VDR), and activation of VDR-responsive genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 48-66 21278761-2 2011 Vitamin D mediates its effect though binding to vitamin D receptor (VDR), and activation of VDR-responsive genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 68-71 21278761-2 2011 Vitamin D mediates its effect though binding to vitamin D receptor (VDR), and activation of VDR-responsive genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 92-95 21623580-4 2011 Furthermore, the mechanisms by which the VDR might mediate either the genomic and nongenomic (rapid) vitamin D-mediated effects became much clearer. Vitamin D 101-110 vitamin D receptor Homo sapiens 41-44 21623580-5 2011 However, new evidence accumulated suggests that some additional receptor(s), responsive to vitamin D and different from the VDR, could play a role in the rapid response to vitamin D, probably interfering also with the genomic pathway. Vitamin D 172-181 vitamin D receptor Homo sapiens 124-127 21070203-10 2011 Fibroblasts transfected with a vitamin D response element reporter construct and exposed to the active vitamin D metabolite 1,25D showed increased promoter activity indicating VDR functionality in these cells. Vitamin D 31-40 vitamin D receptor Homo sapiens 176-179 21070203-10 2011 Fibroblasts transfected with a vitamin D response element reporter construct and exposed to the active vitamin D metabolite 1,25D showed increased promoter activity indicating VDR functionality in these cells. Vitamin D 103-112 vitamin D receptor Homo sapiens 176-179 21440524-1 2011 Vitamin D through the vitamin D nuclear receptor (VDR) plays a key role in mineral ion homeostasis. Vitamin D 0-9 vitamin D receptor Homo sapiens 22-48 22704269-1 2011 The bioactive vitamin D (VD) metabolite, 1,25-dihydroxyvitamin D(3) regulates essential pathways of cellular metabolism and differentiation via its nuclear receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 166-169 21440524-1 2011 Vitamin D through the vitamin D nuclear receptor (VDR) plays a key role in mineral ion homeostasis. Vitamin D 0-9 vitamin D receptor Homo sapiens 50-53 21440524-2 2011 The liver is central in vitamin D synthesis, however the direct involvement of the vitamin D-VDR axis on the liver remains to be evaluated. Vitamin D 83-92 vitamin D receptor Homo sapiens 93-96 21309754-9 2011 Our findings suggest VDR as a potential susceptibility gene and support an essential role of vitamin D in PD. Vitamin D 93-102 vitamin D receptor Homo sapiens 21-24 21371954-5 2011 Vitamin D binds to the vitamin D receptor (VDR) resulting in transcription of a number of genes playing a role in inhibition of MAPK signalling, induction of apoptosis and cell-cycle inhibition, and therefore vitamin D has anti-proliferative and pro-apoptotic effects in cells of many lineages. Vitamin D 0-9 vitamin D receptor Homo sapiens 23-41 21371954-5 2011 Vitamin D binds to the vitamin D receptor (VDR) resulting in transcription of a number of genes playing a role in inhibition of MAPK signalling, induction of apoptosis and cell-cycle inhibition, and therefore vitamin D has anti-proliferative and pro-apoptotic effects in cells of many lineages. Vitamin D 0-9 vitamin D receptor Homo sapiens 43-46 21371954-5 2011 Vitamin D binds to the vitamin D receptor (VDR) resulting in transcription of a number of genes playing a role in inhibition of MAPK signalling, induction of apoptosis and cell-cycle inhibition, and therefore vitamin D has anti-proliferative and pro-apoptotic effects in cells of many lineages. Vitamin D 23-32 vitamin D receptor Homo sapiens 43-46 21408608-12 2011 Although vitamin D regulates LVSCC-A1C through VDR, it may not regulate LVSCC-A1D through VDR. Vitamin D 9-18 vitamin D receptor Homo sapiens 47-50 21524386-2 2011 Vitamin D receptor (VDR) is a nuclear receptor that mediates most biological functions of 1,25(OH)(2)D(3) or vitamin D(3), the active form of vitamin D. Vitamin D 109-118 vitamin D receptor Homo sapiens 0-18 21524386-2 2011 Vitamin D receptor (VDR) is a nuclear receptor that mediates most biological functions of 1,25(OH)(2)D(3) or vitamin D(3), the active form of vitamin D. Vitamin D 109-118 vitamin D receptor Homo sapiens 20-23 21524386-2 2011 Vitamin D receptor (VDR) is a nuclear receptor that mediates most biological functions of 1,25(OH)(2)D(3) or vitamin D(3), the active form of vitamin D. Vitamin D 142-151 vitamin D receptor Homo sapiens 0-18 21524386-2 2011 Vitamin D receptor (VDR) is a nuclear receptor that mediates most biological functions of 1,25(OH)(2)D(3) or vitamin D(3), the active form of vitamin D. Vitamin D 142-151 vitamin D receptor Homo sapiens 20-23 21454240-7 2011 CONCLUSION: Future studies investigating the relationship of the vitamin D receptor, calcium-sensing receptor, and parathyroid glands are needed to enhance our knowledge of vitamin D deficiency and primary and secondary vitamin D deficiency. Vitamin D 173-182 vitamin D receptor Homo sapiens 65-83 21168462-1 2011 The Vitamin D receptor (VDR) gene encodes a transcription factor which, on activation by vitamin D, modulates diverse biologic processes, including calcium homeostasis and immune function. Vitamin D 89-98 vitamin D receptor Homo sapiens 4-22 21123297-1 2011 Transcriptional regulation by hormonal 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] involves occupancy of vitamin D response elements (VDREs) by the VDRE binding protein (VDRE-BP) or 1,25(OH)(2)D(3)-bound vitamin D receptor (VDR). Vitamin D 53-62 vitamin D receptor Homo sapiens 205-223 21123297-1 2011 Transcriptional regulation by hormonal 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] involves occupancy of vitamin D response elements (VDREs) by the VDRE binding protein (VDRE-BP) or 1,25(OH)(2)D(3)-bound vitamin D receptor (VDR). Vitamin D 53-62 vitamin D receptor Homo sapiens 135-138 21168462-1 2011 The Vitamin D receptor (VDR) gene encodes a transcription factor which, on activation by vitamin D, modulates diverse biologic processes, including calcium homeostasis and immune function. Vitamin D 89-98 vitamin D receptor Homo sapiens 24-27 21503197-2 2011 Both forms of vitamin D are biologically inactive pro-hormones that must undergo sequential hydroxylations in the liver and the kidney before they can bind to and activate the vitamin D receptor. Vitamin D 14-23 vitamin D receptor Homo sapiens 176-194 21164021-4 2011 Independent of changes in intestinal calcium absorption and serum calcium, 1alpha,25-dihydroxyvitamin D also represses the transcription of PTH by associating with the vitamin D receptor, which heterodimerizes with retinoic acid X receptors to bind vitamin D-response elements within the PTH gene. Vitamin D 94-103 vitamin D receptor Homo sapiens 168-186 21283672-7 2011 The functional significance of the VDR FokI polymorphism in vitamin D action is undefined. Vitamin D 60-69 vitamin D receptor Homo sapiens 35-38 20980105-4 2011 Binding of the active vitamin D metabolite 1,25(OH)(2)D(3) to vitamin D receptor (VDR) yields a transcription factor which represses NF-kappaB activation, and additionally modulates and down-regulates adaptive, but enhances innate immune responses, and improves redox balance, thus counterbalancing inflammation on multiple levels. Vitamin D 22-31 vitamin D receptor Homo sapiens 62-80 20980105-4 2011 Binding of the active vitamin D metabolite 1,25(OH)(2)D(3) to vitamin D receptor (VDR) yields a transcription factor which represses NF-kappaB activation, and additionally modulates and down-regulates adaptive, but enhances innate immune responses, and improves redox balance, thus counterbalancing inflammation on multiple levels. Vitamin D 22-31 vitamin D receptor Homo sapiens 82-85 21131899-1 2011 BACKGROUND: Apart from their important role in mediating calcium homeostasis, vitamin D derivatives regulate numerous vitamin D receptor-mediated renoprotective cellular functions including cell differentiation, negative regulation of inflammation, and fibrosis. Vitamin D 78-87 vitamin D receptor Homo sapiens 118-136 20431993-0 2011 Vitamin D status in relation to obesity, bone mineral density, bone turnover markers and vitamin D receptor genotypes in healthy Saudi pre- and postmenopausal women. Vitamin D 0-9 vitamin D receptor Homo sapiens 89-107 21852710-7 2011 These findings help provide a biological explanation for the increased risk of more rapid disease progression observed in HIV-infected persons with low levels of vitamin D or with genetic variants within the vitamin D receptor that alter binding to vitamin D. Vitamin D 162-171 vitamin D receptor Homo sapiens 208-226 21062631-11 2011 SIGNIFICANCE: These results suggest that the vitamin D metabolite 24, 25-(OH)(2)D(3) is an endogenous regulator of apo A-I synthesis through a VDR-independent signaling mechanism. Vitamin D 45-54 vitamin D receptor Homo sapiens 143-146 21215445-14 2011 Vitamin D did not significantly affect time to sputum culture conversion in the whole study population, but it did significantly hasten sputum culture conversion in participants with the tt genotype of the TaqI vitamin D receptor polymorphism. Vitamin D 0-9 vitamin D receptor Homo sapiens 211-229 21991434-5 2011 Vitamin D"s antiprostate cancer activities may be involved in the actions through the pathways mediated by vitamin D metabolites, vitamin D metabolizing enzymes, vitamin D receptor (VDR), and VDR-regulated genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 162-180 21991434-5 2011 Vitamin D"s antiprostate cancer activities may be involved in the actions through the pathways mediated by vitamin D metabolites, vitamin D metabolizing enzymes, vitamin D receptor (VDR), and VDR-regulated genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 182-185 21991434-5 2011 Vitamin D"s antiprostate cancer activities may be involved in the actions through the pathways mediated by vitamin D metabolites, vitamin D metabolizing enzymes, vitamin D receptor (VDR), and VDR-regulated genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 192-195 21625107-5 2011 In the chronic kidney disease (CKD) population, vitamin D receptor (VDR) activation deficiency is even more severe than in a non-CKD population, with a 25-(OH) vitamin D level being an independent predictor of all-cause mortality. Vitamin D 48-57 vitamin D receptor Homo sapiens 68-71 20619365-2 2011 The VDR is a nuclear, ligand-induced transcription factor that regulates in complex with hormonally active vitamin D the expression of more than 900 genes involved in a wide array of physiological functions (e.g. calcium homeostasis, growth control, differentiation, cognition, immune response, etc.). Vitamin D 107-116 vitamin D receptor Homo sapiens 4-7 21114675-2 2011 T cells express the vitamin D receptor (VDR) and have been shown to be direct and indirect vitamin D targets. Vitamin D 20-29 vitamin D receptor Homo sapiens 40-43 22145479-0 2011 Report of two unrelated patients with hereditary vitamin D resistant rickets due to the same novel mutation in the vitamin D receptor. Vitamin D 49-58 vitamin D receptor Homo sapiens 115-133 21197695-4 2011 Furthermore, the physiological functions with which vitamin D signalling is now associated are as diverse as the tissues in which the VDR is located. Vitamin D 52-61 vitamin D receptor Homo sapiens 134-137 21269569-1 2011 Most of the biological actions of vitamin D are mediated by an intracellular receptor (VDR) in which several single nucleotide gene polymorphisms have been identified. Vitamin D 34-43 vitamin D receptor Homo sapiens 87-90 20966550-9 2011 Administration of vitamin D to this model protected neurons by preventing cytotoxicity and apoptosis, and also by downregulating LVSCC A1C and upregulating VDR. Vitamin D 18-27 vitamin D receptor Homo sapiens 156-159 20795934-7 2011 Here we review molecular actions of the vitamin D receptor (VDR), to identify mechanisms and pathways for vitamin D deficiency as a universal risk factor. Vitamin D 40-49 vitamin D receptor Homo sapiens 60-63 20795934-8 2011 To identify genes directly regulated by the VDR, we searched for genes containing vitamin D response elements (VDREs). Vitamin D 82-91 vitamin D receptor Homo sapiens 44-47 21291397-7 2011 The three-dimensional structure of both rat and human VDR-LBD have provided significant information for our understanding of the structure-function relationship (SFR) of vitamin D and some synthetic analogs. Vitamin D 170-179 vitamin D receptor Homo sapiens 54-57 22145480-3 2011 Vitamin D dependent rickets type 2 (VDDR-II) is caused by a defect in the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 74-92 22145480-3 2011 Vitamin D dependent rickets type 2 (VDDR-II) is caused by a defect in the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 94-97 22219556-8 2011 Anti-inflammatory activity of vitamin D is impaired in neonatal neutrophils, and this may be due to decreased expression of VDR and 1alpha-hydroxylase. Vitamin D 30-39 vitamin D receptor Homo sapiens 124-127 20955794-2 2011 The anticancer effects of vitamin D are mediated primarily by its active metabolite, 1,25-dihydroxyvitamin D (calcitriol), through vitamin D receptor (VDR) signaling. Vitamin D 26-35 vitamin D receptor Homo sapiens 131-149 20955794-2 2011 The anticancer effects of vitamin D are mediated primarily by its active metabolite, 1,25-dihydroxyvitamin D (calcitriol), through vitamin D receptor (VDR) signaling. Vitamin D 26-35 vitamin D receptor Homo sapiens 151-154 20955794-10 2011 Future large studies to replicate our findings and to assess the impact of VDR gene polymorphisms on VDR expression are required as therapies targeting the vitamin D signaling pathway may be influenced by VDR status in the target lung cancer tissue. Vitamin D 156-165 vitamin D receptor Homo sapiens 101-104 20955794-10 2011 Future large studies to replicate our findings and to assess the impact of VDR gene polymorphisms on VDR expression are required as therapies targeting the vitamin D signaling pathway may be influenced by VDR status in the target lung cancer tissue. Vitamin D 156-165 vitamin D receptor Homo sapiens 101-104 20855290-1 2011 The nuclear receptor vitamin D receptor (VDR) is known to associate with two vitamin D response element (VDRE) containing chromatin regions of the insulin-like growth factor binding protein 3 (IGFBP3) gene. Vitamin D 21-30 vitamin D receptor Homo sapiens 41-44 22046258-10 2011 In the North Carolina AAs, for whom we had vitamin D intake data, we found a significant association between an intronic SNP rs11574041 and vitamin D intake, which is evidence for a VDR gene-environment interaction in AAs. Vitamin D 140-149 vitamin D receptor Homo sapiens 182-185 21419266-7 2011 These include coordinated actions of the vitamin D-activating enzyme, 1alpha-hydroxylase (CYP27B1), and the vitamin D receptor (VDR) in mediating intracrine and paracrine actions of vitamin D. Vitamin D 108-117 vitamin D receptor Homo sapiens 128-131 21829599-6 2011 We confirmed the binding of the VDR phage to active Vitamin D in vitro, as well as the higher expression of VDR in CD4+CD25+ cells. Vitamin D 52-61 vitamin D receptor Homo sapiens 32-35 20684976-11 2010 Deficiency in vitamin D may provide an etiologic link between the long-known ecologic findings regarding latitude and the basic science noting polymorphisms in the vitamin D receptor. Vitamin D 14-23 vitamin D receptor Homo sapiens 164-182 20863562-2 2010 The actions of vitamin D are mediated by the vitamin D receptor that binds the active form of vitamin D [1,25(OH)(2)D] to induce both transcriptional and non-genomic responses. Vitamin D 15-24 vitamin D receptor Homo sapiens 45-63 21143098-2 2010 Vitamin D has been shown to exert multiple immunomodulatory effects, which act through its own receptor (vitamin D receptor). Vitamin D 0-9 vitamin D receptor Homo sapiens 105-123 21113195-1 2010 Vitamin D is a seco-steroid involved in calcium and phosphorus metabolism, and bone formation and mineralization, through binding to a specific nuclear receptor, vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 162-180 21113195-1 2010 Vitamin D is a seco-steroid involved in calcium and phosphorus metabolism, and bone formation and mineralization, through binding to a specific nuclear receptor, vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 182-185 20639756-2 2010 The studies of signaling pathways involved in the response to infection and inflammation have led to a more detailed understanding of the cellular response to Vitamin D through VDR. Vitamin D 159-168 vitamin D receptor Homo sapiens 177-180 20639756-3 2010 This review summarizes recent progress in understanding how Vitamin D contributes to mucosal immune function, particularly in relation to the molecular mechanisms by which Vitamin D and VDR influence mucosal immunity, bacterial infection, and inflammation. Vitamin D 60-69 vitamin D receptor Homo sapiens 186-189 20639756-12 2010 Studies have indicated that the dysregulation of VDR may lead to exaggerated inflammatory responses, raising the possibility that defects in Vitamin D and VDR signaling transduction may be linked to bacterial infection and chronic inflammation. Vitamin D 141-150 vitamin D receptor Homo sapiens 49-52 20890434-7 2010 Based on the present results, therapies targeting the activity of TLRs, AMPs and vitamin D, including modulation of the TLR-VDR pathways, might provide new therapeutic approaches to the psoriasis and other inflammatory skin diseases. Vitamin D 81-90 vitamin D receptor Homo sapiens 124-127 20605845-3 2010 The activated vitamin D brings about its actions through the vitamin D receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 61-79 20605845-3 2010 The activated vitamin D brings about its actions through the vitamin D receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 81-84 20883026-2 2010 We have identified an o-aminoanilide analogue of the hormonal form of vitamin D with a dienyl side chain that functions as a strong VDR antagonist. Vitamin D 70-79 vitamin D receptor Homo sapiens 132-135 20736230-2 2010 However, the mode of action of vitamin D, through its cognate nuclear vitamin D receptor (VDR), and its contribution to diverse disorders, remain poorly understood. Vitamin D 31-40 vitamin D receptor Homo sapiens 70-88 20736230-2 2010 However, the mode of action of vitamin D, through its cognate nuclear vitamin D receptor (VDR), and its contribution to diverse disorders, remain poorly understood. Vitamin D 31-40 vitamin D receptor Homo sapiens 90-93 20667908-3 2010 In addition, over the past decade there has been a dramatic increase in our understanding of the many biological actions that result from vitamin D acting through its daughter steroid hormone, 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] in collaboration with its cognate vitamin D receptor (VDR). Vitamin D 138-147 vitamin D receptor Homo sapiens 282-300 20733005-1 2010 Hormonal vitamin D, 1,25-dihydroxyvitamin D (1,25D), signals through the nuclear vitamin D receptor (VDR). Vitamin D 9-18 vitamin D receptor Homo sapiens 81-99 20733005-1 2010 Hormonal vitamin D, 1,25-dihydroxyvitamin D (1,25D), signals through the nuclear vitamin D receptor (VDR). Vitamin D 9-18 vitamin D receptor Homo sapiens 101-104 20831823-0 2010 Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions. Vitamin D 15-24 vitamin D receptor Homo sapiens 100-103 20831823-12 2010 Thus, during mammary malignant transformation, tumour cells lose their ability to synthesize the active form of Vitamin D and respond to VDR-mediated Vitamin D effects, while increasing their ability to degrade this hormone. Vitamin D 150-159 vitamin D receptor Homo sapiens 137-140 20616160-1 2010 The role of vitamin D in multiple organ systems has come into sharp focus with recent advances in the understanding of its mechanisms of actions and specific effects of vitamin D preparations that serve as substrates and those that directly activate the vitamin D receptor. Vitamin D 12-21 vitamin D receptor Homo sapiens 254-272 20667908-3 2010 In addition, over the past decade there has been a dramatic increase in our understanding of the many biological actions that result from vitamin D acting through its daughter steroid hormone, 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] in collaboration with its cognate vitamin D receptor (VDR). Vitamin D 138-147 vitamin D receptor Homo sapiens 302-305 20711952-8 2010 Vitamin D stimulates ovarian steroidogenesis and IGFBP-1 production in human ovarian cells likely acting via vitamin D receptor. Vitamin D 0-9 vitamin D receptor Homo sapiens 109-127 20450955-1 2010 The biologically active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) ligands VDR (vitamin D receptor) and binds to the vitamin D response element (VDRE) located within target genes to regulate their transcription. Vitamin D 32-41 vitamin D receptor Homo sapiens 83-86 20506379-1 2010 Vitamin D is a steroid pro-hormone, whose active metabolite binds the vitamin D receptor (VDR) which, in turn, binds to DNA sequences on target genes as a heterodimer with the retinoid-X receptor, resulting in regulation of gene expression. Vitamin D 0-9 vitamin D receptor Homo sapiens 70-88 20506379-1 2010 Vitamin D is a steroid pro-hormone, whose active metabolite binds the vitamin D receptor (VDR) which, in turn, binds to DNA sequences on target genes as a heterodimer with the retinoid-X receptor, resulting in regulation of gene expression. Vitamin D 0-9 vitamin D receptor Homo sapiens 90-93 20506379-4 2010 Investigations into the pathophysiologic basis and therapeutic responses of skeletal disorders associated with impaired vitamin D action have led to the identification of the molecular pathways involved in hormone activation and regulation of gene expression by the liganded VDR. Vitamin D 120-129 vitamin D receptor Homo sapiens 275-278 20450955-1 2010 The biologically active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) ligands VDR (vitamin D receptor) and binds to the vitamin D response element (VDRE) located within target genes to regulate their transcription. Vitamin D 32-41 vitamin D receptor Homo sapiens 88-106 20450955-1 2010 The biologically active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) ligands VDR (vitamin D receptor) and binds to the vitamin D response element (VDRE) located within target genes to regulate their transcription. Vitamin D 57-66 vitamin D receptor Homo sapiens 83-86 20450955-1 2010 The biologically active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) ligands VDR (vitamin D receptor) and binds to the vitamin D response element (VDRE) located within target genes to regulate their transcription. Vitamin D 57-66 vitamin D receptor Homo sapiens 88-106 20407924-5 2010 Vitamin-D acts through vitamin-D-receptor (VDR), which regulates the expression of vitamin-D-response genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 23-41 20407924-5 2010 Vitamin-D acts through vitamin-D-receptor (VDR), which regulates the expression of vitamin-D-response genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 43-46 20407924-5 2010 Vitamin-D acts through vitamin-D-receptor (VDR), which regulates the expression of vitamin-D-response genes. Vitamin D 23-32 vitamin D receptor Homo sapiens 43-46 20675935-3 2010 Loss-of-function mutation of 1alpha-hydroxylase gene and loss-of-function mutation of VDR gene result in vitamin D-dependent rickets type I and type II, respectively. Vitamin D 105-114 vitamin D receptor Homo sapiens 86-89 20334872-11 2010 VDR expression is unlikely to represent an independent prognostic factor, but its presence within biopsy specimens might be used to identify patients that are suited to high-dose vitamin D therapeutic trials. Vitamin D 179-188 vitamin D receptor Homo sapiens 0-3 21073129-2 2010 Mutations in the VDR cause the rare genetic disease hereditary vitamin D resistant rickets (HVDRR). Vitamin D 63-72 vitamin D receptor Homo sapiens 17-20 20394945-3 2010 Vitamin D receptor expression (VDR), 24-hydroxylase activity, and functional gene polymorphisms of vitamin D metabolism regulators VDR(rs4516035), 1-hydroxylase(rs10877012), 24-hydroxylase(rs2248359), FGF23(rs7955866), Klotho(rs9536314, rs564481, rs648202), were evaluated. Vitamin D 99-108 vitamin D receptor Homo sapiens 131-134 20628264-1 2010 OBJECTIVE: Vitamin D has been shown to have multiple biological targets mediated by the vitamin D receptor present in many cells. Vitamin D 11-20 vitamin D receptor Homo sapiens 88-106 20227497-3 2010 Vitamin D also elicits numerous intracrine actions when circulating 25-hydroxyvitamin D3, the metabolite reflecting vitamin D status, is converted to 1,25D locally by extrarenal CYP27B1, and binds VDR to promote immunoregulation, antimicrobial defense, xenobiotic detoxification, anti-inflammatory/anticancer actions and cardiovascular benefits. Vitamin D 0-9 vitamin D receptor Homo sapiens 197-200 20171278-0 2010 Genome-wide analysis of the VDR/RXR cistrome in osteoblast cells provides new mechanistic insight into the actions of the vitamin D hormone. Vitamin D 122-131 vitamin D receptor Homo sapiens 28-31 20493879-4 2010 In silico screening of the MYC gene locus identified six putative binding sites [vitamin D response elements (VDREs)] for the vitamin D receptor (VDR). Vitamin D 81-90 vitamin D receptor Homo sapiens 126-144 20493879-4 2010 In silico screening of the MYC gene locus identified six putative binding sites [vitamin D response elements (VDREs)] for the vitamin D receptor (VDR). Vitamin D 81-90 vitamin D receptor Homo sapiens 110-113 20562186-1 2010 A role for vitamin D in ovarian cancer etiology is supported by ecologic studies of sunlight exposure, experimental mechanism studies, and some studies of dietary vitamin D intake and genetic polymorphisms in the vitamin D receptor. Vitamin D 11-20 vitamin D receptor Homo sapiens 213-231 20138989-1 2010 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25D), has a broad range of effects which are mediated by nuclear vitamin D receptor (VDR). Vitamin D 19-28 vitamin D receptor Homo sapiens 128-146 20138989-1 2010 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25D), has a broad range of effects which are mediated by nuclear vitamin D receptor (VDR). Vitamin D 19-28 vitamin D receptor Homo sapiens 148-151 20138990-1 2010 Vitamin D receptor (VDR) mediates the antitumoral action of the active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3). Vitamin D 71-80 vitamin D receptor Homo sapiens 0-18 20171278-1 2010 The vitamin D receptor (VDR) mediates the actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in target cells and tissues by orchestrating the expression of gene networks responsible for vitamin D-induced phenotypes. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 20227497-3 2010 Vitamin D also elicits numerous intracrine actions when circulating 25-hydroxyvitamin D3, the metabolite reflecting vitamin D status, is converted to 1,25D locally by extrarenal CYP27B1, and binds VDR to promote immunoregulation, antimicrobial defense, xenobiotic detoxification, anti-inflammatory/anticancer actions and cardiovascular benefits. Vitamin D 78-87 vitamin D receptor Homo sapiens 197-200 20138990-1 2010 Vitamin D receptor (VDR) mediates the antitumoral action of the active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3). Vitamin D 71-80 vitamin D receptor Homo sapiens 20-23 20398755-7 2010 In conclusion, the -1012 VDRp genotype appears to be associated with height in European children whatever their calcium/dairy product intakes, and may modulate their calcium homeostasis in conditions of low calcium/milk intakes when vitamin D status is sufficient. Vitamin D 233-242 vitamin D receptor Homo sapiens 25-29 20403435-1 2010 In the nuclear receptor of vitamin D (VDR) histidine 305 participates to the anchoring of the ligand. Vitamin D 27-36 vitamin D receptor Homo sapiens 38-41 20403435-2 2010 The VDR H305Q mutation was identified in a patient who exhibited the hereditary vitamin D-resistant rickets (HVDRR). Vitamin D 80-89 vitamin D receptor Homo sapiens 4-7 20304061-2 2010 Vitamin D is thought to have both direct (through activation of the vitamin D receptor) and indirect (via regulation of calcium homeostasis) effects on various mechanisms related to the pathophysiology of both types of diabetes, including pancreatic beta-cell dysfunction, impaired insulin action and systemic inflammation. Vitamin D 0-9 vitamin D receptor Homo sapiens 68-86 20307661-0 2010 Association between polymorphic variation in VDR and RXRA and circulating levels of vitamin D metabolites. Vitamin D 84-93 vitamin D receptor Homo sapiens 45-48 20307661-1 2010 The vitamin D metabolite 1,25(OH)2D is the bioactive ligand of the vitamin D receptor (VDR). Vitamin D 4-13 vitamin D receptor Homo sapiens 67-85 20307661-1 2010 The vitamin D metabolite 1,25(OH)2D is the bioactive ligand of the vitamin D receptor (VDR). Vitamin D 4-13 vitamin D receptor Homo sapiens 87-90 20637153-1 2010 OBJECTIVE: To study the correlation between vitamin D receptor genetic polymorphism Fokand vitamin D deficiency rickets in children between 1 to 3 years old, and to explore the significance of hereditary factors in the development of vitamin D deficiency rickets. Vitamin D 91-100 vitamin D receptor Homo sapiens 44-62 20307661-2 2010 VDR forms a heterodimer with the retinoid X receptors (RXRs) that when bound to ligand influences the transcriptional control of genes that regulate circulating levels of vitamin D metabolites. Vitamin D 171-180 vitamin D receptor Homo sapiens 0-3 20420906-1 2010 The vitamin D receptor (VDR) typically binds DNA in a heterodimer complex with the retinoid X receptor (RXR) to direct repeat sequences separated by three base pairs, or vitamin D response elements (VDREs). Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 20511050-1 2010 The actions of the vitamin D hormone 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) are mediated by the vitamin D receptor (VDR), a ligand-activated transcription factor that functions to control gene expression. Vitamin D 19-28 vitamin D receptor Homo sapiens 102-120 20511050-1 2010 The actions of the vitamin D hormone 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) are mediated by the vitamin D receptor (VDR), a ligand-activated transcription factor that functions to control gene expression. Vitamin D 19-28 vitamin D receptor Homo sapiens 122-125 20511055-5 2010 When the VDR is defective, the disease hereditary vitamin D-resistant rickets, also known as vitamin D-dependent rickets type 2, develops. Vitamin D 50-59 vitamin D receptor Homo sapiens 9-12 20511055-5 2010 When the VDR is defective, the disease hereditary vitamin D-resistant rickets, also known as vitamin D-dependent rickets type 2, develops. Vitamin D 93-102 vitamin D receptor Homo sapiens 9-12 20536781-0 2010 Vitamin D and stress fracture: the contribution of vitamin D receptor gene polymorphisms. Vitamin D 0-9 vitamin D receptor Homo sapiens 51-69 20592360-2 2010 The antiproliferative effects of calcitriol (1,25(OH)(2)D(3)) mediated via the vitamin D receptor (VDR) render vitamin D a promising target in breast cancer therapy. Vitamin D 79-88 vitamin D receptor Homo sapiens 99-102 20236932-1 2010 CYP24A1 expression is up-regulated by 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) via a vitamin D receptor (VDR)/retinoid X receptor (RXR) heterodimer that binds to two vitamin D response elements (VDREs) located near the proximal promoter. Vitamin D 52-61 vitamin D receptor Homo sapiens 89-107 20236932-1 2010 CYP24A1 expression is up-regulated by 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) via a vitamin D receptor (VDR)/retinoid X receptor (RXR) heterodimer that binds to two vitamin D response elements (VDREs) located near the proximal promoter. Vitamin D 52-61 vitamin D receptor Homo sapiens 109-112 20172873-1 2010 BACKGROUND: The vitamin D receptor (VDR) is expressed in human testis, and vitamin D (VD) has been suggested to affect survival and function of mature spermatozoa. Vitamin D 16-25 vitamin D receptor Homo sapiens 36-39 20406950-3 2010 It is known that the interaction of the vitamin D metabolite 1,25-dihydroxyvitamin D(3) (1,25D) with its functional vitamin D receptor leads to differentiation, G(1) arrest, and increased cell survival in p53-null AML cells. Vitamin D 40-49 vitamin D receptor Homo sapiens 116-134 20206692-4 2010 The expressions of the key factors involved in VDR transactivity, including CYP24A1 and VDR-associated proteins are all increased in LNCaP-R cells, and yet treatment with ketoconazole, P450 enzymes inhibitor, as well as trichostatin A (TSA), a histone deacetylase inhibitor, did not sensitize LNCaP-R cells response to vitamin D, suggesting that neither a local 1,25-VD availability, nor VDR-associated proteins are responsible for the vitamin D resistance. Vitamin D 319-328 vitamin D receptor Homo sapiens 47-50 20206692-4 2010 The expressions of the key factors involved in VDR transactivity, including CYP24A1 and VDR-associated proteins are all increased in LNCaP-R cells, and yet treatment with ketoconazole, P450 enzymes inhibitor, as well as trichostatin A (TSA), a histone deacetylase inhibitor, did not sensitize LNCaP-R cells response to vitamin D, suggesting that neither a local 1,25-VD availability, nor VDR-associated proteins are responsible for the vitamin D resistance. Vitamin D 319-328 vitamin D receptor Homo sapiens 88-91 20206692-4 2010 The expressions of the key factors involved in VDR transactivity, including CYP24A1 and VDR-associated proteins are all increased in LNCaP-R cells, and yet treatment with ketoconazole, P450 enzymes inhibitor, as well as trichostatin A (TSA), a histone deacetylase inhibitor, did not sensitize LNCaP-R cells response to vitamin D, suggesting that neither a local 1,25-VD availability, nor VDR-associated proteins are responsible for the vitamin D resistance. Vitamin D 319-328 vitamin D receptor Homo sapiens 88-91 20206692-4 2010 The expressions of the key factors involved in VDR transactivity, including CYP24A1 and VDR-associated proteins are all increased in LNCaP-R cells, and yet treatment with ketoconazole, P450 enzymes inhibitor, as well as trichostatin A (TSA), a histone deacetylase inhibitor, did not sensitize LNCaP-R cells response to vitamin D, suggesting that neither a local 1,25-VD availability, nor VDR-associated proteins are responsible for the vitamin D resistance. Vitamin D 436-445 vitamin D receptor Homo sapiens 47-50 20206692-4 2010 The expressions of the key factors involved in VDR transactivity, including CYP24A1 and VDR-associated proteins are all increased in LNCaP-R cells, and yet treatment with ketoconazole, P450 enzymes inhibitor, as well as trichostatin A (TSA), a histone deacetylase inhibitor, did not sensitize LNCaP-R cells response to vitamin D, suggesting that neither a local 1,25-VD availability, nor VDR-associated proteins are responsible for the vitamin D resistance. Vitamin D 436-445 vitamin D receptor Homo sapiens 88-91 20206692-4 2010 The expressions of the key factors involved in VDR transactivity, including CYP24A1 and VDR-associated proteins are all increased in LNCaP-R cells, and yet treatment with ketoconazole, P450 enzymes inhibitor, as well as trichostatin A (TSA), a histone deacetylase inhibitor, did not sensitize LNCaP-R cells response to vitamin D, suggesting that neither a local 1,25-VD availability, nor VDR-associated proteins are responsible for the vitamin D resistance. Vitamin D 436-445 vitamin D receptor Homo sapiens 88-91 20206692-5 2010 Interestingly, nuclear factor-kappaB (NF-kappaB) signaling, which is critical for 1,25-VD/VDR activity was found reduced in LNCaP-R cells, thereby treatment with NF-kappaB activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), can sensitize LNCaP-R vitamin D response. Vitamin D 249-258 vitamin D receptor Homo sapiens 90-93 20119827-2 2010 The importance of vitamin D on the regulation of cells of the immune system has gained increased appreciation over the past decade with the discovery of the vitamin D receptor (VDR) and key vitamin D metabolizing enzymes expressed by cells of the immune system. Vitamin D 18-27 vitamin D receptor Homo sapiens 157-175 20119827-2 2010 The importance of vitamin D on the regulation of cells of the immune system has gained increased appreciation over the past decade with the discovery of the vitamin D receptor (VDR) and key vitamin D metabolizing enzymes expressed by cells of the immune system. Vitamin D 18-27 vitamin D receptor Homo sapiens 177-180 20119827-2 2010 The importance of vitamin D on the regulation of cells of the immune system has gained increased appreciation over the past decade with the discovery of the vitamin D receptor (VDR) and key vitamin D metabolizing enzymes expressed by cells of the immune system. Vitamin D 157-166 vitamin D receptor Homo sapiens 177-180 20303786-2 2010 The CaR regulates the release of parathyroid hormone (PTH) in response to changes in extracellular calcium, whereas the VDR mediates the effects of calcitriol, the active metabolite of vitamin D. Vitamin D 185-194 vitamin D receptor Homo sapiens 120-123 20363711-8 2010 Vitamin D deficiency is widespread in the older adult population as a result of low dietary intake, decreased sun exposure, decreased intrinsic vitamin D production, and decreased vitamin D receptor activity. Vitamin D 0-9 vitamin D receptor Homo sapiens 180-198 20435872-1 2010 There has been much recent interest in the role of the vitamin D axis in lung disease, which includes vitamin D, vitamin D receptor (VDR) and vitamin D-binding protein (VDBP; also known as Gc-globulin). Vitamin D 55-64 vitamin D receptor Homo sapiens 113-131 20435872-1 2010 There has been much recent interest in the role of the vitamin D axis in lung disease, which includes vitamin D, vitamin D receptor (VDR) and vitamin D-binding protein (VDBP; also known as Gc-globulin). Vitamin D 55-64 vitamin D receptor Homo sapiens 133-136 20043299-1 2010 The activity of beta-catenin, commonly dysregulated in human colon cancers, is inhibited by the vitamin D receptor (VDR), and this mechanism is postulated to explain the putative anti-cancer activity of vitamin D metabolites in the colon. Vitamin D 96-105 vitamin D receptor Homo sapiens 116-119 20398021-1 2010 The bioactive form of vitamin D, 1,25-dihydroxyvitamin D(3), is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the nuclear receptor superfamily, and modulates a variety of biological functions. Vitamin D 22-31 vitamin D receptor Homo sapiens 104-122 20398021-1 2010 The bioactive form of vitamin D, 1,25-dihydroxyvitamin D(3), is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the nuclear receptor superfamily, and modulates a variety of biological functions. Vitamin D 22-31 vitamin D receptor Homo sapiens 124-127 20133492-5 2010 VDR agonists effectively treat SHPT and vitamin D deficiency, but dosing needs to be optimized for each patient because the patient responds in an individualized manner to treatment to suppress and stabilize PTH levels. Vitamin D 40-49 vitamin D receptor Homo sapiens 0-3 19783860-4 2010 VDR, CYP27B1 or CYP2R1 gene variants could modify the biological activity of vitamin D(3). Vitamin D 77-86 vitamin D receptor Homo sapiens 0-3 20145122-2 2010 The biological actions of the hormonal form of vitamin D, 1,25(OH)(2)D(3), are mediated by the vitamin D receptor (VDR), which heterodimerizes with retinoid X receptors (RXR). Vitamin D 47-56 vitamin D receptor Homo sapiens 95-113 20145122-2 2010 The biological actions of the hormonal form of vitamin D, 1,25(OH)(2)D(3), are mediated by the vitamin D receptor (VDR), which heterodimerizes with retinoid X receptors (RXR). Vitamin D 47-56 vitamin D receptor Homo sapiens 115-118 19735754-9 2010 However, vitamin D supplementation increased whole body bone mineral density (BMD) (p=0.007) and bone mineral content (BMC) (p=0.048) in the FF VDR genotype but not in the Ff or ff VDR genotypes. Vitamin D 9-18 vitamin D receptor Homo sapiens 144-147 19735754-9 2010 However, vitamin D supplementation increased whole body bone mineral density (BMD) (p=0.007) and bone mineral content (BMC) (p=0.048) in the FF VDR genotype but not in the Ff or ff VDR genotypes. Vitamin D 9-18 vitamin D receptor Homo sapiens 181-184 19885846-2 2010 Vitamin D(3) binds to the vitamin D(3) receptor (VDR), a member of the superfamily of nuclear receptors, which in turn interacts with transcriptional activators to target this regulatory complex to specific sequence elements within gene promoters. Vitamin D 0-9 vitamin D receptor Homo sapiens 26-47 19885846-2 2010 Vitamin D(3) binds to the vitamin D(3) receptor (VDR), a member of the superfamily of nuclear receptors, which in turn interacts with transcriptional activators to target this regulatory complex to specific sequence elements within gene promoters. Vitamin D 0-9 vitamin D receptor Homo sapiens 49-52 19885846-4 2010 Previous reports indicated that the VDR exhibits a punctate nuclear distribution that is significantly enhanced in cells grown in the presence of vitamin D(3). Vitamin D 146-155 vitamin D receptor Homo sapiens 36-39 19885846-6 2010 This interaction of VDR with the nuclear matrix occurs rapidly after vitamin D(3) addition and does not require a functional VDR DNA-binding domain. Vitamin D 69-78 vitamin D receptor Homo sapiens 20-23 19885846-8 2010 Together these results indicate that after ligand stimulation the VDR rapidly enters the nucleus and associates with the nuclear matrix preceding vitamin D(3)-transcriptional upregulation. Vitamin D 146-155 vitamin D receptor Homo sapiens 66-69 20308705-1 2010 There is increasing evidence for health benefits accomplished by activated vitamin D through interaction with the vitamin D receptor (VDR) that go beyond calcium and bone homeostasis and regulation of parathyroid hormone (PTH) secretion. Vitamin D 75-84 vitamin D receptor Homo sapiens 114-132 20308705-1 2010 There is increasing evidence for health benefits accomplished by activated vitamin D through interaction with the vitamin D receptor (VDR) that go beyond calcium and bone homeostasis and regulation of parathyroid hormone (PTH) secretion. Vitamin D 75-84 vitamin D receptor Homo sapiens 134-137 19931390-4 2010 Fibroblasts transfected with a vitamin D response element-reporter construct and exposed to the active vitamin D metabolite, 1,25(OH)(2)D(3), showed increased promoter activity indicating VDR functionality in these cells. Vitamin D 31-40 vitamin D receptor Homo sapiens 188-191 19931390-4 2010 Fibroblasts transfected with a vitamin D response element-reporter construct and exposed to the active vitamin D metabolite, 1,25(OH)(2)D(3), showed increased promoter activity indicating VDR functionality in these cells. Vitamin D 103-112 vitamin D receptor Homo sapiens 188-191 19837082-2 2010 In an activity-guided approach using reporter gene assays where the distal part of the 5-LO gene was included in the reporter gene plasmid, we localized vitamin D response elements (VDREs) within exon 10, exon 12, and intron M. We found that these newly identified VDRE sites are bound by vitamin D receptor both in vitro by gel-shift analysis and in vivo by chromatin immunoprecipitation assays. Vitamin D 153-162 vitamin D receptor Homo sapiens 289-307 21433310-1 2010 INTRODUCTION: Vitamin D is an important modulator of the autoimmune process exerting its effects through the nuclear vitamin D receptor (VDR) with transcription factor properties. Vitamin D 14-23 vitamin D receptor Homo sapiens 117-135 19948723-1 2010 Vitamin D signaling through its nuclear vitamin D receptor has emerged as a key regulator of innate immunity in humans. Vitamin D 0-9 vitamin D receptor Homo sapiens 40-58 21433310-1 2010 INTRODUCTION: Vitamin D is an important modulator of the autoimmune process exerting its effects through the nuclear vitamin D receptor (VDR) with transcription factor properties. Vitamin D 14-23 vitamin D receptor Homo sapiens 137-140 21433310-2 2010 Mutations in the VDR gene may be important for vitamin D action on immunocompetent cells. Vitamin D 47-56 vitamin D receptor Homo sapiens 17-20 21433310-4 2010 The aim of this study was (a) to assess the relationship between the presence of BsmI VDR gene polymorphism and RA susceptibility, activity, and progression; (b) to compare vitamin D serum concentration in RA patients and in the control group; (c) to correlate vitamin D concentration in serum, vitamin D substitution in patients, demographic data, disease duration, RA functional and radiologic grade, RA activity, and presence of some antibodies. Vitamin D 173-182 vitamin D receptor Homo sapiens 86-89 19921089-1 2010 Vitamin D-dependent rickets type II (VDDR-type II) is a rare disorder caused by mutations in the vitamin D receptor (VDR) gene. Vitamin D 0-9 vitamin D receptor Homo sapiens 97-115 19921089-1 2010 Vitamin D-dependent rickets type II (VDDR-type II) is a rare disorder caused by mutations in the vitamin D receptor (VDR) gene. Vitamin D 0-9 vitamin D receptor Homo sapiens 117-120 20055894-12 2010 This effect is produced through vitamin D response elements (VDREs), located in the promoter regions of these genes, suggesting that LCA acts as a mild analogous of vitamin D, interacting with the vitamin D receptor. Vitamin D 32-41 vitamin D receptor Homo sapiens 197-215 21139376-3 2010 Liganded VDR heterodimerizes with the retinoid X receptor and interacts with a vitamin D response element (VDRE). Vitamin D 79-88 vitamin D receptor Homo sapiens 9-12 20055894-12 2010 This effect is produced through vitamin D response elements (VDREs), located in the promoter regions of these genes, suggesting that LCA acts as a mild analogous of vitamin D, interacting with the vitamin D receptor. Vitamin D 165-174 vitamin D receptor Homo sapiens 197-215 20049159-1 2010 Mediated by binding to the high-affinity vitamin D receptor (VDR), vitamin D forms a heterodimer complex with the retinoid-X-receptor (RXR). Vitamin D 41-50 vitamin D receptor Homo sapiens 61-64 19693091-1 2010 Vitamin D exhibits immunomodulatory and antiproliferative effects through vitamin D receptor (VDR) in chronic infections and cancers. Vitamin D 0-9 vitamin D receptor Homo sapiens 74-92 19693091-1 2010 Vitamin D exhibits immunomodulatory and antiproliferative effects through vitamin D receptor (VDR) in chronic infections and cancers. Vitamin D 0-9 vitamin D receptor Homo sapiens 94-97 19724293-4 2009 Impairment of cooperative signalling from the 1,25-(OH)(2)D(3)-activated vitamin D receptor (VDR) and from the CaR in vitamin D and calcium insufficiency causes cellular dysfunction in many organs and biological systems, and, therefore, increases the risk of diseases, particularly of osteoporosis, colorectal and breast cancer, inflammatory bowel disease, insulin-dependent diabetes mellitus type I, metabolic syndrome, diabetes mellitus type II, hypertension and cardiovascular disease. Vitamin D 73-82 vitamin D receptor Homo sapiens 93-96 20003690-2 2010 The vitamin D receptor (VDR) gene has been studied as a candidate locus due to genetic polymorphisms that affects the activity of the receptor and subsequent downstream vitamin D-mediated effects. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 20003690-8 2010 CONCLUSIONS: The association of VDR polymorphisms with risk of TB observed in our analyses supports the hypothesis that vitamin D deficiency might play a role as risk factor during the development of TB. Vitamin D 120-129 vitamin D receptor Homo sapiens 32-35 19801650-1 2009 (23S)-25-Dehydro-1alpha(OH)-vitamin D(3)-26,23-lactone (MK) is an antagonist of the 1alpha,25(OH)(2)-vitamin D(3) (1,25D)/human nuclear vitamin D receptor (hVDR) transcription initiation complex, where the activation helix (i.e. helix-12) is closed. Vitamin D 28-37 vitamin D receptor Homo sapiens 136-154 19801650-1 2009 (23S)-25-Dehydro-1alpha(OH)-vitamin D(3)-26,23-lactone (MK) is an antagonist of the 1alpha,25(OH)(2)-vitamin D(3) (1,25D)/human nuclear vitamin D receptor (hVDR) transcription initiation complex, where the activation helix (i.e. helix-12) is closed. Vitamin D 28-37 vitamin D receptor Homo sapiens 156-160 19800081-4 2009 Vitamin D mediates its function through a single vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 49-67 19800081-4 2009 Vitamin D mediates its function through a single vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 69-72 19800081-5 2009 Polymorphisms of the VDR have major effects on vitamin D function and metabolism, and some VDR genotypes have been linked to osteoporosis and MS. Because the safety of high doses of vitamin D has not been established yet, vitamin D hasn"t been used in enough doses to increase the serum level to a desired therapeutic target. Vitamin D 47-56 vitamin D receptor Homo sapiens 21-24 19800081-5 2009 Polymorphisms of the VDR have major effects on vitamin D function and metabolism, and some VDR genotypes have been linked to osteoporosis and MS. Because the safety of high doses of vitamin D has not been established yet, vitamin D hasn"t been used in enough doses to increase the serum level to a desired therapeutic target. Vitamin D 182-191 vitamin D receptor Homo sapiens 91-94 19800081-5 2009 Polymorphisms of the VDR have major effects on vitamin D function and metabolism, and some VDR genotypes have been linked to osteoporosis and MS. Because the safety of high doses of vitamin D has not been established yet, vitamin D hasn"t been used in enough doses to increase the serum level to a desired therapeutic target. Vitamin D 182-191 vitamin D receptor Homo sapiens 91-94 19647104-0 2009 Vitamin D receptor gene polymorphisms modulate the skeletal response to vitamin D supplementation in healthy girls. Vitamin D 72-81 vitamin D receptor Homo sapiens 0-18 19647104-3 2009 This study investigated whether the musculo-skeletal response to Vitamin D was modulated by polymorphisms in VDR gene. Vitamin D 65-74 vitamin D receptor Homo sapiens 109-112 19647104-12 2009 CONCLUSION: VDR gene polymorphisms influence the skeletal response to vitamin D supplementation in healthy adolescent girls. Vitamin D 70-79 vitamin D receptor Homo sapiens 12-15 19615888-1 2009 We have carried out melanoma case-control comparisons for six vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) and serum 25-hydroxyvitamin D(3) levels in order to investigate the role of vitamin D in melanoma susceptibility. Vitamin D 62-71 vitamin D receptor Homo sapiens 82-85 19815438-1 2010 The rare genetic recessive disease, hereditary vitamin D resistant rickets (HVDRR), is caused by mutations in the vitamin D receptor (VDR) that result in resistance to the active hormone 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3) or calcitriol). Vitamin D 47-56 vitamin D receptor Homo sapiens 114-132 19815438-1 2010 The rare genetic recessive disease, hereditary vitamin D resistant rickets (HVDRR), is caused by mutations in the vitamin D receptor (VDR) that result in resistance to the active hormone 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3) or calcitriol). Vitamin D 47-56 vitamin D receptor Homo sapiens 77-80 19815438-10 2010 However, the V26M mutation inhibited VDR binding to a consensus vitamin D response element (VDRE). Vitamin D 64-73 vitamin D receptor Homo sapiens 37-40 20003316-2 2009 Vitamin D is now recognised as having pleiotropic roles beyond bone and mineral homeostasis, with the vitamin D receptor and metabolising machinery identified in multiple tissues. Vitamin D 0-9 vitamin D receptor Homo sapiens 102-120 19895218-6 2009 The capacity of the vitamin D receptor to act as a high-affinity receptor for vitamin D and a low-affinity receptor for secondary bile acids and potentially other novel nutritional compounds suggests that the evolutionary selection to place the cathelicidin gene under control of the vitamin D receptor allows for its regulation under both endocrine and xenobiotic response systems. Vitamin D 20-29 vitamin D receptor Homo sapiens 284-302 19900346-4 2009 Vitamin D is most well known for its role in bone health; however, the discovery of VDR on a wide variety of tissue types has also opened up roles for vitamin D far beyond traditional bone health. Vitamin D 151-160 vitamin D receptor Homo sapiens 84-87 19545951-7 2009 Vitamin D acts through two types of receptors: (i) the vitamin D receptor (VDR), a member of the steroid/thyroid hormone superfamily of transcription factors, and (ii) the MARRS (membrane associated, rapid response steroid binding) receptor, also known as Erp57/Grp58. Vitamin D 0-9 vitamin D receptor Homo sapiens 55-73 19545951-7 2009 Vitamin D acts through two types of receptors: (i) the vitamin D receptor (VDR), a member of the steroid/thyroid hormone superfamily of transcription factors, and (ii) the MARRS (membrane associated, rapid response steroid binding) receptor, also known as Erp57/Grp58. Vitamin D 0-9 vitamin D receptor Homo sapiens 75-78 19861519-2 2009 Common polymorphisms in the vitamin D receptor (VDR) are associated with VDR activity and are therefore potentially useful proxies for assessing whether vitamin D is causally related to advanced prostate cancer. Vitamin D 28-37 vitamin D receptor Homo sapiens 48-51 19861519-2 2009 Common polymorphisms in the vitamin D receptor (VDR) are associated with VDR activity and are therefore potentially useful proxies for assessing whether vitamin D is causally related to advanced prostate cancer. Vitamin D 28-37 vitamin D receptor Homo sapiens 73-76 19941273-3 2009 Vitamin D is a hormone whose actions take place through a specific receptor, the vitamin D receptor (VDR), which is ubiquitous. Vitamin D 0-9 vitamin D receptor Homo sapiens 81-99 19765252-4 2009 Combined cinacalcet and vitamin D can reportedly increase vitamin D receptor expression. Vitamin D 24-33 vitamin D receptor Homo sapiens 58-76 19941273-3 2009 Vitamin D is a hormone whose actions take place through a specific receptor, the vitamin D receptor (VDR), which is ubiquitous. Vitamin D 0-9 vitamin D receptor Homo sapiens 101-104 19941276-5 2009 The use of VDR activators to treat these and other parameters outside of cardiovascular and renal disease not only results in enhanced patient health but significantly lowers the risk of mortality in CKD and non-CKD patients with low systemic activity of vitamin D. Vitamin D 255-264 vitamin D receptor Homo sapiens 11-14 19863778-0 2009 Anti-proliferative action of vitamin D in MCF7 is still active after siRNA-VDR knock-down. Vitamin D 29-38 vitamin D receptor Homo sapiens 75-78 19411183-9 2009 CONCLUSIONS: Our findings suggest that VDR polymorphisms may be associated with nasal carriage of S. aureus in individuals with T1D, and further contribute to the better understanding of the immunomodulatory role of vitamin D in the human host"s response and susceptibility to infection. Vitamin D 216-225 vitamin D receptor Homo sapiens 39-42 19829313-3 2009 Definition of the adequate amount of vitamin D, however, is still uncertain; polymorphisms of the gene encoding the vitamin D receptor might be responsible for this uncertainty. Vitamin D 37-46 vitamin D receptor Homo sapiens 116-134 19666701-6 2009 The PCFT promoter region is transactivated by the vitamin D receptor (VDR) and its heterodimeric partner retinoid X receptor-alpha (RXRalpha) in the presence of vitamin D(3). Vitamin D 50-59 vitamin D receptor Homo sapiens 70-73 19787215-3 2009 Vitamin D, which works through binding the vitamin D receptor (VDR) has an important role in cancer progression and immune response. Vitamin D 0-9 vitamin D receptor Homo sapiens 43-61 19787215-3 2009 Vitamin D, which works through binding the vitamin D receptor (VDR) has an important role in cancer progression and immune response. Vitamin D 0-9 vitamin D receptor Homo sapiens 63-66 19523546-0 2009 Hereditary vitamin D resistant rickets: identification of a novel splice site mutation in the vitamin D receptor gene and successful treatment with oral calcium therapy. Vitamin D 11-20 vitamin D receptor Homo sapiens 94-112 19523546-1 2009 OBJECTIVE: To study the vitamin D receptor (VDR) gene in a young girl with severe rickets and clinical features of hereditary vitamin D resistant rickets, including hypocalcemia, hypophosphatemia, partial alopecia, and elevated serum levels of 1,25-dihydroxyvitamin D. Vitamin D 24-33 vitamin D receptor Homo sapiens 44-47 19758159-5 2009 VDR dysregulation, in turn, prevents the breakdown of the active vitamin D metabolite 1,25-hydroxyvitamin D (1,25-D) by CYP24. Vitamin D 65-74 vitamin D receptor Homo sapiens 0-3 19753122-2 2009 Since vitamin D exerts its activity through binding to the nuclear vitamin D receptor (VDR), most genetic studies have primarily focused on variation within this gene. Vitamin D 6-15 vitamin D receptor Homo sapiens 67-85 19753122-2 2009 Since vitamin D exerts its activity through binding to the nuclear vitamin D receptor (VDR), most genetic studies have primarily focused on variation within this gene. Vitamin D 6-15 vitamin D receptor Homo sapiens 87-90 19753122-3 2009 Therefore, analysis of genetic variation in VDR and other vitamin D pathway genes may provide insight into the role of vitamin D in renal cell carcinoma (RCC) etiology. Vitamin D 119-128 vitamin D receptor Homo sapiens 44-47 19371337-2 2009 Calcitriol binds to a nuclear receptor, the vitamin D receptor (VDR), and activates VDR to recruit cofactors to form a transcriptional complex that binds to vitamin D response elements in the promoter region of target genes. Vitamin D 44-53 vitamin D receptor Homo sapiens 64-67 19758226-2 2009 Instead, it is proposed that the lower levels result from chronic infection with intracellular bacteria that dysregulate vitamin D metabolism by causing vitamin D receptor (VDR) dysfunction within phagocytes. Vitamin D 121-130 vitamin D receptor Homo sapiens 153-171 19758226-2 2009 Instead, it is proposed that the lower levels result from chronic infection with intracellular bacteria that dysregulate vitamin D metabolism by causing vitamin D receptor (VDR) dysfunction within phagocytes. Vitamin D 121-130 vitamin D receptor Homo sapiens 173-176 19667166-6 2009 Thus, impairment of antimitogenic, proapoptotic and prodifferentiating signaling from the 1,25(OH)2D3-activated vitamin D receptor (VDR) and from the CaR in vitamin D and calcium insufficiency has been implicated in the pathogenesis of the aforementioned types of cancer. Vitamin D 112-121 vitamin D receptor Homo sapiens 132-135 19667166-7 2009 1,25(OH)2D3 and calcium interact in modulating cell growth in different ways: (i) Signaling pathways from the VDR and the CaR converge on the same downstream elements, e.g. of the canonical Wnt pathway; (ii) high extracellular calcium modulates extrarenal vitamin D metabolism in favor of higher local steady-state concentrations of 1,25(OH)2D3; (iii) 1,25(OH)2D3 may up-regulate expression of the CaR and thus augment CaR-mediated antiproliferative responses to high extracellular Ca2+. Vitamin D 256-265 vitamin D receptor Homo sapiens 110-113 19667142-4 2009 On a genomic level, these pathways converge on regulatory modules, some of which contain VDR-binding sites, so-called vitamin D response elements (VDREs). Vitamin D 118-127 vitamin D receptor Homo sapiens 89-92 19667148-1 2009 BACKGROUND: Vitamin D analog, 1alpha-hydroxy-24-ethyl-cholecalciferol (1alpha(OH)D5), is a less toxic VDR agonist that suppresses proliferation of breast cancer cells in vitro and in vivo. Vitamin D 12-21 vitamin D receptor Homo sapiens 102-105 21088715-1 2009 BACKGROUND: The VDR protein is at the centre of the vitamin D endocrine system, a complex physiological system with substantial feedback regulatory mechanisms involved in maintaining serum calcium and 1, 25 dihydroxy vitamin D3. Vitamin D 52-61 vitamin D receptor Homo sapiens 16-19 19706847-1 2009 Genetic association studies investigating the role of vitamin D in colon cancer have primarily focused on the vitamin D receptor (VDR), with limited data available for other genes in the vitamin D pathway, including vitamin D activating enzyme 1-alpha hydroxylase (CYP27B1) and vitamin D deactivating enzyme 24-alpha hydroxylase (CYP24A1). Vitamin D 110-119 vitamin D receptor Homo sapiens 130-133 19706847-1 2009 Genetic association studies investigating the role of vitamin D in colon cancer have primarily focused on the vitamin D receptor (VDR), with limited data available for other genes in the vitamin D pathway, including vitamin D activating enzyme 1-alpha hydroxylase (CYP27B1) and vitamin D deactivating enzyme 24-alpha hydroxylase (CYP24A1). Vitamin D 110-119 vitamin D receptor Homo sapiens 130-133 19702932-2 2009 In bone cells, the vitamin D receptor (VDR) and the steroid and xenobiotic receptor (SXR) are activated by vitamin D and vitamin K2, respectively. Vitamin D 19-28 vitamin D receptor Homo sapiens 39-42 19502595-1 2009 Vitamin D receptor (VDR) mediates the antitumoral action of the active vitamin D metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)). Vitamin D 71-80 vitamin D receptor Homo sapiens 0-18 19502595-1 2009 Vitamin D receptor (VDR) mediates the antitumoral action of the active vitamin D metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)). Vitamin D 71-80 vitamin D receptor Homo sapiens 20-23 19623255-8 2009 At the same time vitamin D analogs induced cathelicidin through activation of the vitamin D receptor and MEK/ERK signaling. Vitamin D 17-26 vitamin D receptor Homo sapiens 82-100 19414624-8 2009 Higher protein expression of CYP3A4, MRP2, P-gp, and MRP4 was also observed after a 6-day treatment with other vitamin D analogs (100 nM 1alpha-hydroxyvitamin D(3),1alpha-hydroxyvitamin D(2) or Hectorol, and 25-hydroxyvitamin D(3)) in Caco-2 cells, suggesting a role of 1,25(OH)(2)D(3) and analogs in the activation of enzymes and transporters via the vitamin D receptor. Vitamin D 111-120 vitamin D receptor Homo sapiens 352-370 19018272-7 2009 CONCLUSIONS: These preliminary findings suggest that studies of maternal vitamin D status and birth size may need to take VDR genotype into account. Vitamin D 73-82 vitamin D receptor Homo sapiens 122-125 19393200-8 2009 Emerging molecular evidence suggests that symptomatic improvements among those administered vitamin D is the result of 25-D"s ability to temper bacterial-induced inflammation by slowing VDR activity. Vitamin D 92-101 vitamin D receptor Homo sapiens 186-189 19442619-10 2009 On the other hand, although there are some biases, recent large observational studies have demonstrated that vitamin D has beneficial effects on the mortality of patients with CKD independent of serum Ca, P, and parathyroid hormone levels, likely due to its activation of the vitamin D receptor in vasculature and cardiac myocytes. Vitamin D 109-118 vitamin D receptor Homo sapiens 276-294 19448403-5 2009 Recent studies on estrogen and vitamin D, and their receptors (ERalpha/beta, VDR) support now the idea that non-genomic and genomic effects may integrate in a unique mode of action of nuclear receptor ligands, in which the non-genomic effects constitute signaling pathways required for the effects at the genome level. Vitamin D 31-40 vitamin D receptor Homo sapiens 77-80 19622139-1 2009 BACKGROUND: Modulation of the immune system is one of the principal roles of Vitamin D, for which the effects are exerted via the vitamin D receptor (VDR). Vitamin D 77-86 vitamin D receptor Homo sapiens 130-148 19622139-1 2009 BACKGROUND: Modulation of the immune system is one of the principal roles of Vitamin D, for which the effects are exerted via the vitamin D receptor (VDR). Vitamin D 77-86 vitamin D receptor Homo sapiens 150-153 19607716-3 2009 An ancient primate-specific Alu short interspersed element (SINE) put the human CAMP gene under the regulation of the vitamin D pathway by providing a perfect vitamin D receptor binding element (VDRE) in its promoter. Vitamin D 118-127 vitamin D receptor Homo sapiens 159-177 19403841-2 2009 The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 19219539-1 2009 INTRODUCTION: Vitamin D(3), which exerts its effect through vitamin D receptor (VDR), is known for its potent immunomodulatory activities. Vitamin D 14-23 vitamin D receptor Homo sapiens 60-78 19219539-1 2009 INTRODUCTION: Vitamin D(3), which exerts its effect through vitamin D receptor (VDR), is known for its potent immunomodulatory activities. Vitamin D 14-23 vitamin D receptor Homo sapiens 80-83 19393206-5 2009 We conclude that polymorphisms of the VDR have major effects on vitamin D function and metabolism, and should therefore be assessed in studies on vitamin D and MS. Vitamin D 64-73 vitamin D receptor Homo sapiens 38-41 19393206-5 2009 We conclude that polymorphisms of the VDR have major effects on vitamin D function and metabolism, and should therefore be assessed in studies on vitamin D and MS. Vitamin D 146-155 vitamin D receptor Homo sapiens 38-41 19255064-6 2009 Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3" UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status. Vitamin D 56-65 vitamin D receptor Homo sapiens 135-138 19255064-6 2009 Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3" UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status. Vitamin D 202-211 vitamin D receptor Homo sapiens 135-138 19223536-10 2009 Our results of an association with the Fok1 VDR polymorphism further support a role of the vitamin D pathway in ovarian carcinogenesis. Vitamin D 91-100 vitamin D receptor Homo sapiens 44-47 19386033-5 2009 However, sufficient evidence is available to warrant larger epidemiologic studies that should aim to identify possible interactions between VDR polymorphisms and vitamin D status. Vitamin D 162-171 vitamin D receptor Homo sapiens 140-143 19049339-1 2009 Hereditary vitamin D-resistant rickets (HVDRR) is a rare recessive genetic disorder caused by mutations in the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 111-129 19049339-1 2009 Hereditary vitamin D-resistant rickets (HVDRR) is a rare recessive genetic disorder caused by mutations in the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 41-44 19122196-1 2009 The nuclear receptor vitamin D receptor (VDR) is known to associate with three vitamin D response element (VDREs)-containing regions within the CDKN1A (p21) gene region. Vitamin D 21-30 vitamin D receptor Homo sapiens 41-44 19164469-2 2009 The active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] acting through the vitamin D receptor decreases prostate cancer cell growth and invasiveness. Vitamin D 25-34 vitamin D receptor Homo sapiens 105-123 19383117-3 2009 PRESENTATION OF THE HYPOTHESIS: We hypothesize that low availability of 1,25-dihydroxyvitamin D, either due to vitamin D deficiency or due to polymorphisms in the vitamin D receptor or in its activating/inactivating enzymes, contributes to the appearance of IRIS. Vitamin D 86-95 vitamin D receptor Homo sapiens 163-181 19429444-1 2009 The active form of vitamin D(3), 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], is a potent ligand for the nuclear receptor vitamin D receptor (VDR) and induces myeloid leukemia cell differentiation. Vitamin D 19-28 vitamin D receptor Homo sapiens 128-146 19429444-1 2009 The active form of vitamin D(3), 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], is a potent ligand for the nuclear receptor vitamin D receptor (VDR) and induces myeloid leukemia cell differentiation. Vitamin D 19-28 vitamin D receptor Homo sapiens 148-151 18398421-1 2009 BACKGROUND AND OBJECTIVES: Vitamin D and its metabolites act through vitamin D receptor (VDR). Vitamin D 27-36 vitamin D receptor Homo sapiens 69-87 18398421-1 2009 BACKGROUND AND OBJECTIVES: Vitamin D and its metabolites act through vitamin D receptor (VDR). Vitamin D 27-36 vitamin D receptor Homo sapiens 89-92 19008093-1 2009 A comprehensive bibliographic search of the literature was conducted to identify studies on Cutaneous Malignant Melanoma (CMM) and non-melanoma skin cancer (NMSC), Vitamin D receptor (VDR) polymorphisms, Vitamin D intake and 25(OH)D serum levels. Vitamin D 164-173 vitamin D receptor Homo sapiens 184-187 19290791-3 2009 Given the importance of vitamin D in bone homeostasis, common polymorphisms in the vitamin D receptor gene were the first to be investigated as possible determinants of bone mass and fracture risk. Vitamin D 24-33 vitamin D receptor Homo sapiens 83-101 19183053-8 2009 The VDR binding patterns identified in this study may be used to predict functional differences among different tissues expressing different sets of coregulators, thus facilitating the goal of developing tissue- and gene-specific vitamin D response modulators. Vitamin D 230-239 vitamin D receptor Homo sapiens 4-7 19124512-1 2009 BACKGROUND: Vitamin D is hypothesized to lower the risk of breast cancer by inhibiting cell proliferation via the nuclear vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 122-140 19139017-10 2009 Reverse transcription-PCR analysis showed significant up-regulation of VDR and E-cadherin, a downstream target of vitamin D action. Vitamin D 114-123 vitamin D receptor Homo sapiens 71-74 19363780-2 2009 In this review article we summarize the basic concepts regarding vitamin D metabolism, transport, and genomic activity through the vitamin D receptor, facilitating activation or suppression of target genes. Vitamin D 65-74 vitamin D receptor Homo sapiens 131-149 19098224-4 2009 Consistent with this, VDR and SMRT are recruited to the vitamin D response element of the endogenous osteocalcin promoter in the absence of 1alpha,25-(OH)(2)D(3) in chromatin immunoprecipitation assays. Vitamin D 56-65 vitamin D receptor Homo sapiens 22-25 19818218-5 2009 The VDR complex binds in the nucleus to the vitamin D responsive element on the gene. Vitamin D 44-53 vitamin D receptor Homo sapiens 4-7 19400699-1 2009 Higher vitamin D exposure is hypothesized to prevent several cancers, possibly through genomic effects modulated by the vitamin D receptor (VDR), and autocrine/paracrine metabolism of the VDR"s ligand, 1alpha,25-(OH)(2)-vitamin D. Vitamin D 7-16 vitamin D receptor Homo sapiens 120-138 19400699-1 2009 Higher vitamin D exposure is hypothesized to prevent several cancers, possibly through genomic effects modulated by the vitamin D receptor (VDR), and autocrine/paracrine metabolism of the VDR"s ligand, 1alpha,25-(OH)(2)-vitamin D. Vitamin D 7-16 vitamin D receptor Homo sapiens 140-143 19400699-1 2009 Higher vitamin D exposure is hypothesized to prevent several cancers, possibly through genomic effects modulated by the vitamin D receptor (VDR), and autocrine/paracrine metabolism of the VDR"s ligand, 1alpha,25-(OH)(2)-vitamin D. Vitamin D 7-16 vitamin D receptor Homo sapiens 188-191 19400699-2 2009 Herein we review the background and evidence to date on associations between polymorphisms in VDR and selected genes in the vitamin D pathway in relation to colorectal, breast, and prostate cancer. Vitamin D 124-133 vitamin D receptor Homo sapiens 94-97 19124512-1 2009 BACKGROUND: Vitamin D is hypothesized to lower the risk of breast cancer by inhibiting cell proliferation via the nuclear vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 142-145 19494615-5 2009 The hormonally active form of vitamin D (1,25(OH)-D(3) or calcitriol) mediates its biological effects by binding to the vitamin D receptor, which then translocates to the nuclei of the cell and binds to specific DNA sites to modify the expression of target genes. Vitamin D 30-39 vitamin D receptor Homo sapiens 120-138 19287183-1 2009 It has recently been proposed that statins act as vitamin D analogs in binding the ubiquitously expressed vitamin D receptor, accounting for the perceived pleiotropic effects of statins (a reduction in cancer risk, prevention of organ transplant rejection and autoimmune disease). Vitamin D 50-59 vitamin D receptor Homo sapiens 106-124 22276021-2 2009 BACKGROUND: Vitamin D and cancer: calcitriol, the biologically active form of vitamin D (1,25(OH)D), exerts its effects mainly through binding to nuclear vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 154-172 22276021-2 2009 BACKGROUND: Vitamin D and cancer: calcitriol, the biologically active form of vitamin D (1,25(OH)D), exerts its effects mainly through binding to nuclear vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 174-177 22276021-2 2009 BACKGROUND: Vitamin D and cancer: calcitriol, the biologically active form of vitamin D (1,25(OH)D), exerts its effects mainly through binding to nuclear vitamin D receptor (VDR). Vitamin D 78-87 vitamin D receptor Homo sapiens 154-172 22276021-2 2009 BACKGROUND: Vitamin D and cancer: calcitriol, the biologically active form of vitamin D (1,25(OH)D), exerts its effects mainly through binding to nuclear vitamin D receptor (VDR). Vitamin D 78-87 vitamin D receptor Homo sapiens 174-177 22276021-12 2009 In an Italian study, we found that 85% of the participants had insufficient levels of 25(OH)D. We have shown through a meta-analysis of randomized trials that vitamin D supplementation is associated with a significant reduction (7%) in total mortality in healthy subjects and an association between VDR and 25(OH)D and CMM progression has also been demonstrated. Vitamin D 159-168 vitamin D receptor Homo sapiens 299-302 18726998-9 2009 This suggests that decreased recruitment of VDR to vitamin D response elements also contributes to the blunted transcriptional responsiveness to 1,25(OH)(2)D(3) in proliferating Caco-2 cells. Vitamin D 51-60 vitamin D receptor Homo sapiens 44-47 19591520-2 2009 High phosphate, low calcium and vitamin D deficiency represent the classical "triad" involved into the pathogenesis of SHPT in renal insufficiency, in which downregulation of the parathyroid vitamin D receptor and calcium-sensing receptor represents a critical step. Vitamin D 32-41 vitamin D receptor Homo sapiens 191-209 19027855-6 2009 RNA expression of VDR and 24 OHase was upregulated along with vitamin D analogue treatment. Vitamin D 62-71 vitamin D receptor Homo sapiens 18-21 19027855-8 2009 In conclusion, SZ95 sebocytes express VDR and the enzymatic machinery to synthesize and metabolize biologically active vitamin D analogues. Vitamin D 119-128 vitamin D receptor Homo sapiens 38-41 19287183-3 2009 Vitamin D suppresses parathyroid hormone (PTH) secretion in part through its action on the vitamin D receptor. Vitamin D 0-9 vitamin D receptor Homo sapiens 91-109 18827005-2 2008 OBJECTIVE: Genetic variants in the promoter region of the vitamin D receptor (VDR) gene may explain the response to treatment because this receptor mediates vitamin D action. Vitamin D 58-67 vitamin D receptor Homo sapiens 78-81 20010502-3 2009 The restriction polymorphisms in VDR gene could be involved in the modulation of vitamin D action and modulate the level of bone mineral density (BMD) and the risk to develop osteopenia and osteoporosis. Vitamin D 81-90 vitamin D receptor Homo sapiens 33-36 18644400-0 2008 Side-chain modified vitamin D analogs induce rapid accumulation of VDR in the cell nuclei proportionately to their differentiation-inducing potential. Vitamin D 20-29 vitamin D receptor Homo sapiens 67-70 18647306-1 2008 BACKGROUND: Vitamin D has a range of biological effects including antiproliferative functions that are mediated through its receptors, encoded by the VDR gene. Vitamin D 12-21 vitamin D receptor Homo sapiens 150-153 24410609-1 2008 "Vitamin D" is a generic term for a family of secosteroids, members of which bind to the vitamin D receptor. Vitamin D 1-10 vitamin D receptor Homo sapiens 89-107 18709640-0 2008 Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding. Vitamin D 56-65 vitamin D receptor Homo sapiens 189-192 18709640-0 2008 Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding. Vitamin D 155-164 vitamin D receptor Homo sapiens 189-192 18709640-2 2008 Many mechanisms of action for vitamin D have been proposed, with some of them initiating via its binding to the vitamin D receptor (VDR). Vitamin D 30-39 vitamin D receptor Homo sapiens 112-130 18709640-2 2008 Many mechanisms of action for vitamin D have been proposed, with some of them initiating via its binding to the vitamin D receptor (VDR). Vitamin D 30-39 vitamin D receptor Homo sapiens 132-135 18709640-7 2008 The evidence of interaction we report here further supports the inverse association between vitamin D mediated through binding to the VDR. Vitamin D 92-101 vitamin D receptor Homo sapiens 134-137 18767073-2 2008 The vitamin D metabolite 1alpha,25(OH)2D3 mediates growth inhibitory signaling via activation of the vitamin D receptor (VDR), a ligand dependent transcription factor. Vitamin D 4-13 vitamin D receptor Homo sapiens 101-119 18767073-2 2008 The vitamin D metabolite 1alpha,25(OH)2D3 mediates growth inhibitory signaling via activation of the vitamin D receptor (VDR), a ligand dependent transcription factor. Vitamin D 4-13 vitamin D receptor Homo sapiens 121-124 18767073-4 2008 Human mammary epithelial (HME) cells express VDR and CYP27b1 and undergo growth inhibition when exposed to physiological concentrations of 25(OH)D3, suggesting that autocrine or paracrine vitamin D signaling contributes to maintenance of differentiation and quiescence in the mammary epithelium. Vitamin D 188-197 vitamin D receptor Homo sapiens 45-48 18844849-4 2008 The remarkable range of the effects of vitamin D relates to our new understanding of both the role of the vitamin D receptor and analyses of what might be considered an optimum vitamin D status in populations exposed to very different diets and levels of sun exposure. Vitamin D 39-48 vitamin D receptor Homo sapiens 106-124 19015318-1 2008 The active vitamin D metabolite 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) inhibits proliferation and promotes differentiation of colon cancer cells through the activation of vitamin D receptor (VDR), a transcription factor of the nuclear receptor superfamily. Vitamin D 11-20 vitamin D receptor Homo sapiens 177-195 19015318-1 2008 The active vitamin D metabolite 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) inhibits proliferation and promotes differentiation of colon cancer cells through the activation of vitamin D receptor (VDR), a transcription factor of the nuclear receptor superfamily. Vitamin D 11-20 vitamin D receptor Homo sapiens 197-200 19014363-5 2008 In fact, it is known that VDR is a transcription factor, and that in vitamin-D-depleted animals, VDR is largely localized in the cell nucleus. Vitamin D 69-78 vitamin D receptor Homo sapiens 97-100 18495457-9 2008 Similarly, genistein potentiated vitamin D"s inhibition of adipogenesis and induction of apoptosis in maturing preadipocytes by an enhanced expression of VDR (vitamin D receptor) protein. Vitamin D 33-42 vitamin D receptor Homo sapiens 154-157 18495457-9 2008 Similarly, genistein potentiated vitamin D"s inhibition of adipogenesis and induction of apoptosis in maturing preadipocytes by an enhanced expression of VDR (vitamin D receptor) protein. Vitamin D 33-42 vitamin D receptor Homo sapiens 159-177 18832725-5 2008 Stimulation of the same cells with the vitamin D(3) monocyte differentiation inducer resulted in a clear increase of Hox-A10 and MafB transcripts, indicating the existence of a precise transactivation cascade involving vitamin D(3) receptor, Hox-A10, and MafB transcription factors. Vitamin D 39-48 vitamin D receptor Homo sapiens 219-240 18694980-0 2008 Vitamin D and human health: lessons from vitamin D receptor null mice. Vitamin D 0-9 vitamin D receptor Homo sapiens 41-59 19035286-4 2008 Previous work has demonstrated that the most active vitamin D metabolite, 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) inhibits beta-catenin transcriptional activity by promoting vitamin D receptor (VDR) binding to beta-catenin and the induction of E-cadherin expression. Vitamin D 52-61 vitamin D receptor Homo sapiens 178-196 19035286-4 2008 Previous work has demonstrated that the most active vitamin D metabolite, 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) inhibits beta-catenin transcriptional activity by promoting vitamin D receptor (VDR) binding to beta-catenin and the induction of E-cadherin expression. Vitamin D 52-61 vitamin D receptor Homo sapiens 198-201 18485278-1 2008 The regulation of vitamin D receptor (VDR), a key mediator in the vitamin D pathway, in breast cancer etiology has long been of interest. Vitamin D 18-27 vitamin D receptor Homo sapiens 38-41 18602086-7 2008 Luciferase assays using mutated constructs revealed that the VDR-binding sites of DR3, DR4(I), MdC3, and DR4(III) contribute to the induction, indicating that these binding sites act as vitamin D response elements (VDREs). Vitamin D 186-195 vitamin D receptor Homo sapiens 61-64 18689389-4 2008 Over the past several decades, the biological sphere of influence of vitamin D(3), as defined by the tissue distribution of the VDR, has broadened at least 9-fold from the target organs required for calcium homeostasis (intestine, bone, kidney, and parathyroid). Vitamin D 69-78 vitamin D receptor Homo sapiens 128-131 18689389-7 2008 This article identifies the fundamentals of the vitamin D endocrine system, including its potential for contributions to good health in 5 physiologic arenas in which investigators have clearly documented new biological actions of 1alpha,25(OH)(2)D(3) through the VDR. Vitamin D 48-57 vitamin D receptor Homo sapiens 263-266 18758137-7 2008 1alpha-Methyl-2alpha-(3-hydroxypropyl)-25-hydroxyvitamin D(3) improved the binding affinity for the mutant VDR(Arg274Leu), which causes hereditary vitamin D resistant rickets. Vitamin D 49-58 vitamin D receptor Homo sapiens 107-110 18426327-0 2008 Vitamin D-dependent rickets type II: report of a novel mutation in the vitamin D receptor gene. Vitamin D 0-9 vitamin D receptor Homo sapiens 71-89 18348143-5 2008 Mechanistic studies using chromatin immunoprecipitation (ChIP) assay revealed that a direct repeat-3 (DR3) vitamin D response element located in the first intron of the G6PD genome can be bound by liganded vitamin D receptor, thereby regulating G6PD gene expression. Vitamin D 107-116 vitamin D receptor Homo sapiens 206-224 18501591-13 2008 In contrast, (23S)-25-deoxy-1alpha-hydroxyvitamin D(3)-26,23-lactone, which only blocks human VDR, these vitamin D antagonists can block VDR in human cells and rodent cells. Vitamin D 42-51 vitamin D receptor Homo sapiens 137-140 18068275-1 2008 The QSAR is an alternative method for the research of new and better Vitamin D analogues with affinity for the VDR receptor. Vitamin D 69-78 vitamin D receptor Homo sapiens 111-114 18068275-2 2008 This paper describes the results of applying the Radial Distribution Function (RDF descriptors) approach for predicting the VDR affinity of 38 vitamin D analogues. Vitamin D 143-152 vitamin D receptor Homo sapiens 124-127 18515093-2 2008 1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the hormonal form of vitamin D, is involved in the anti-inflammatory action through VDR. Vitamin D 14-23 vitamin D receptor Homo sapiens 130-133 18518851-4 2008 Furthermore, varying responsiveness to vitamin D and estrogen-based treatments may reflect allele variation in their signaling pathway genes (e.g., VDR or ERalpha). Vitamin D 39-48 vitamin D receptor Homo sapiens 148-151 18426327-1 2008 Hereditary vitamin D-resistant rickets type or vitamin D-dependent rickets type II is a genetically determined and rare autosomal recessive disorder, most often caused by mutations in the vitamin D receptor gene. Vitamin D 11-20 vitamin D receptor Homo sapiens 188-206 18426327-1 2008 Hereditary vitamin D-resistant rickets type or vitamin D-dependent rickets type II is a genetically determined and rare autosomal recessive disorder, most often caused by mutations in the vitamin D receptor gene. Vitamin D 47-56 vitamin D receptor Homo sapiens 188-206 18483332-2 2008 The active metabolite of vitamin D, 1,25-dihydroxycholecalciferol (calcitriol), has been shown to have antiproliferative effects in several tumor types, mediated by the vitamin D receptor (VDR). Vitamin D 25-34 vitamin D receptor Homo sapiens 169-187 18483332-2 2008 The active metabolite of vitamin D, 1,25-dihydroxycholecalciferol (calcitriol), has been shown to have antiproliferative effects in several tumor types, mediated by the vitamin D receptor (VDR). Vitamin D 25-34 vitamin D receptor Homo sapiens 189-192 18175872-4 2008 It has been reported that direct vitamin D injection into parathyroid gland (PTG) efficiently decreased PTH level without significant changes of Ca level in dialysis patients as well as in uremic animals, possibly through up-regulation of CaSR and vitamin D receptor and decrease of cell number in PTC. Vitamin D 33-42 vitamin D receptor Homo sapiens 248-266 18454815-4 2008 The remarkable range of the effects of vitamin D relates to our new understanding of both the role of the vitamin D receptor and analyses of what might be considered an optimum vitamin D status in populations exposed to very different diets and levels of sun exposure. Vitamin D 39-48 vitamin D receptor Homo sapiens 106-124 18379402-1 2008 STUDY DESIGN: Human lumbar anulus tissue and cultured human lumbar anulus cells were used in retrospective studies of the immunocytochemical localization of the vitamin D receptor (VDR) in disc tissue, and of the in vitro effects of the active metabolite of vitamin D, 1,25(OH)2D3, on anulus cell proliferation, cytokine, and proteoglycan (PG) production. Vitamin D 161-170 vitamin D receptor Homo sapiens 181-184 18497440-2 2008 Vitamin D is a prohormone which is converted into its active hormonal form 1, 25 (OH)D2 D, 1, 25 (OH)D2 D activates its cellular receptor (VDR) which activate target genes to engender its biological actions. Vitamin D 0-9 vitamin D receptor Homo sapiens 139-142 18266602-4 2008 These data provide preliminary evidence of associations of VDR polymorphisms with the risk of ALRI (predominantly viral bronchiolitis) in young children, consistent with a potential role of vitamin D in the immune response to respiratory tract infection. Vitamin D 190-199 vitamin D receptor Homo sapiens 59-62 18429807-2 2008 Hypocalcemic vitamin D-resistant rickets represents a specific type of rickets that is attributed to vitamin D receptor defect rather than to vitamin D deficiency. Vitamin D 13-22 vitamin D receptor Homo sapiens 101-119 18419802-1 2008 INTRODUCTION: Vitamin D receptor (VDR) genotypes may influence breast cancer risk by altering potential anticarcinogenic effects of vitamin D, but epidemiological studies have been inconsistent. Vitamin D 132-141 vitamin D receptor Homo sapiens 14-32 18419802-1 2008 INTRODUCTION: Vitamin D receptor (VDR) genotypes may influence breast cancer risk by altering potential anticarcinogenic effects of vitamin D, but epidemiological studies have been inconsistent. Vitamin D 132-141 vitamin D receptor Homo sapiens 34-37 18182164-3 2008 Gel shift analysis indicated that GA reduced vitamin D-mediated DNA binding activity of the vitamin D receptor (VDR). Vitamin D 45-54 vitamin D receptor Homo sapiens 92-110 18182164-3 2008 Gel shift analysis indicated that GA reduced vitamin D-mediated DNA binding activity of the vitamin D receptor (VDR). Vitamin D 45-54 vitamin D receptor Homo sapiens 112-115 18079052-1 2008 The vitamin D receptor (VDR) is a critical mediator of the cellular effects of vitamin D. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 18327422-6 2008 RESULTS: TACO gene down-regulation observed with vitamin D(3)/RA treatment occurred through modulation of this gene via the VDR/RXR response sequence present in the promoter region of TACO gene. Vitamin D 49-58 vitamin D receptor Homo sapiens 124-127 18211694-13 2008 The latter, together with findings demonstrating specific effects of calcitriol acting through the VDR and the cAMP/PKA signaling pathway upon hCG expression and secretion, indicate that there is a functional vitamin D endocrine system in the placenta, and recognize calcitriol as an autocrine regulator of hCG. Vitamin D 209-218 vitamin D receptor Homo sapiens 99-102 18213391-6 2008 We conclude that VDR is a TCF/Lef-independent transcriptional effector of the Wnt pathway and that vitamin D analogues have therapeutic potential in tumors with inappropriate activation of Wnt signalling. Vitamin D 99-108 vitamin D receptor Homo sapiens 17-20 17970811-0 2008 A novel mutation in the VDR gene in hereditary vitamin D-resistant rickets. Vitamin D 47-56 vitamin D receptor Homo sapiens 24-27 17723171-2 2007 The vitamin D receptor (VDR) is expressed in mammary epithelial cells, suggesting that vitamin D may directly influence sensitivity of the gland to transformation. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 18246496-2 2008 The kidney is a major organ for vitamin D metabolism, activity, and calcium homeostasis; therefore, it was hypothesized that dietary vitamin D intake and polymorphisms in the vitamin D receptor (VDR) gene may modify renal cell carcinoma (RCC) risk. Vitamin D 32-41 vitamin D receptor Homo sapiens 175-193 18246496-2 2008 The kidney is a major organ for vitamin D metabolism, activity, and calcium homeostasis; therefore, it was hypothesized that dietary vitamin D intake and polymorphisms in the vitamin D receptor (VDR) gene may modify renal cell carcinoma (RCC) risk. Vitamin D 32-41 vitamin D receptor Homo sapiens 195-198 18998068-2 2008 In addition, bile acids may play a role in colorectal cancer pathogenesis because they reduce the chemopreventive efficiency of calcium and vitamin D by interfering with calcium and vitamin D receptor-activated anti-mitogenic intracellular signalling in neoplastic colonocytes. Vitamin D 140-149 vitamin D receptor Homo sapiens 182-200 18290716-9 2007 In either case, the 1,25(OH)(2)D ligand is required for the VDR to heterodimerize with the retinoid x receptor and compete away the dominant-negative acting, heterogeneous nuclear ribonucleoprotein (hnRNP)-related, vitamin D response element-binding proteins that inhibit hormone-directed transactivation of genes. Vitamin D 215-224 vitamin D receptor Homo sapiens 60-63 17716971-9 2007 Finally, we show that upon DNA damage, induction of VDR sensitizes the cells to vitamin D treatment. Vitamin D 80-89 vitamin D receptor Homo sapiens 52-55 18491455-3 2008 Vitamin D exerts its effects through the Vitamin D Receptor, coded for by a gene showing several polymorphisms associated with a variety of diseases and differential responses to Vitamin D. Vitamin D 0-9 vitamin D receptor Homo sapiens 41-59 18161000-2 2008 Vitamin D is a known immune system modulator and its effects are exerted via the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 81-99 18161000-2 2008 Vitamin D is a known immune system modulator and its effects are exerted via the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 101-104 18365588-0 2008 Vitamin D receptor gene polymorphisms in Turkish children with vitamin D deficient rickets. Vitamin D 63-72 vitamin D receptor Homo sapiens 0-18 18365588-2 2008 In order to check whether vitamin D receptor (VDR) gene polymorphism relates to the vitamin D deficient rickets, we analyzed VDR gene FokI, TaqI and ApaI polymorphisms in 24 Turkish vitamin D deficient rickets patients and 100 healthy controls. Vitamin D 26-35 vitamin D receptor Homo sapiens 46-49 18365588-5 2008 Our results indicated that VDR gene polymorphisms might be an important factor for genetic susceptibility to vitamin D deficient rickets in the Turkish population. Vitamin D 109-118 vitamin D receptor Homo sapiens 27-30 18290711-8 2007 The functional characterization of the patient"s VDR reflected the localization of the mutation (18 different ones described to date), thus providing vital information about the structure-function relationship in the human VDR and the essentiality of the VDR as the mediator of vitamin D action. Vitamin D 278-287 vitamin D receptor Homo sapiens 49-52 18290711-8 2007 The functional characterization of the patient"s VDR reflected the localization of the mutation (18 different ones described to date), thus providing vital information about the structure-function relationship in the human VDR and the essentiality of the VDR as the mediator of vitamin D action. Vitamin D 278-287 vitamin D receptor Homo sapiens 223-226 18290711-8 2007 The functional characterization of the patient"s VDR reflected the localization of the mutation (18 different ones described to date), thus providing vital information about the structure-function relationship in the human VDR and the essentiality of the VDR as the mediator of vitamin D action. Vitamin D 278-287 vitamin D receptor Homo sapiens 223-226 18290715-1 2007 The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes. Vitamin D 4-13 vitamin D receptor Homo sapiens 109-127 18290715-1 2007 The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes. Vitamin D 4-13 vitamin D receptor Homo sapiens 129-132 18290715-1 2007 The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes. Vitamin D 37-46 vitamin D receptor Homo sapiens 109-127 18290715-1 2007 The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes. Vitamin D 37-46 vitamin D receptor Homo sapiens 129-132 17967727-1 2007 The discovery of the vitamin D receptor (VDR) in the cells of the immune system and the fact that activated dendritic cells produce the vitamin D hormone suggested that vitamin D could have immunoregulatory properties. Vitamin D 21-30 vitamin D receptor Homo sapiens 41-44 17932346-0 2007 Comprehensive association analysis of the vitamin D pathway genes, VDR, CYP27B1, and CYP24A1, in prostate cancer. Vitamin D 42-51 vitamin D receptor Homo sapiens 67-70 17932346-9 2007 Our findings suggest that polymorphisms in the VDR gene may be associated with prostate cancer risk and, therefore, that the vitamin D pathway might have an etiologic role in the development of prostate cancer. Vitamin D 125-134 vitamin D receptor Homo sapiens 47-50 17628009-10 2007 These data provide proof of principle that UV exposure modulates tumor growth via elevation of vitamin D signaling and that therapeutic approaches designed to target the vitamin D pathway will be effective only if tumor cells express functional VDR. Vitamin D 170-179 vitamin D receptor Homo sapiens 245-248 17855664-10 2007 Our data suggest that the integrity of the vitamin D/VDR-mediated signaling pathway is crucial in predicting vitamin D responsiveness and thus provide a rational design to improve vitamin D-based treatment efficacy based on molecular profiles of patients. Vitamin D 43-52 vitamin D receptor Homo sapiens 53-56 17644135-4 2007 Vitamin D receptor expression was examined by Western immunoblot analysis after incubating the cells with 250 to 800 nM vitamin D, 10 to 70 nM testosterone, 2 nM calcium or a combination of the 3 products. Vitamin D 120-129 vitamin D receptor Homo sapiens 0-18 17644135-9 2007 Sequential concentrations of vitamin D increased vitamin D receptor expression intensity. Vitamin D 29-38 vitamin D receptor Homo sapiens 49-67 17644135-10 2007 Simultaneous addition of vitamin D and testosterone decreased the vitamin D receptor signal, as did testosterone alone. Vitamin D 25-34 vitamin D receptor Homo sapiens 66-84 17644135-11 2007 Delayed administration of vitamin D 5 hours after testosterone showed the return of vitamin D receptor expression. Vitamin D 26-35 vitamin D receptor Homo sapiens 84-102 17855664-10 2007 Our data suggest that the integrity of the vitamin D/VDR-mediated signaling pathway is crucial in predicting vitamin D responsiveness and thus provide a rational design to improve vitamin D-based treatment efficacy based on molecular profiles of patients. Vitamin D 109-118 vitamin D receptor Homo sapiens 53-56 17855664-10 2007 Our data suggest that the integrity of the vitamin D/VDR-mediated signaling pathway is crucial in predicting vitamin D responsiveness and thus provide a rational design to improve vitamin D-based treatment efficacy based on molecular profiles of patients. Vitamin D 109-118 vitamin D receptor Homo sapiens 53-56 17487855-11 2007 VDR expression may constitute an important prerequisite for using vitamin D and/or its analogs in the treatment of CCA. Vitamin D 66-75 vitamin D receptor Homo sapiens 0-3 17565270-3 2007 RECENT FINDINGS: Vitamin D-induced transcriptional repression of several negative vitamin D receptor target genes has been studied on a molecular level. Vitamin D 17-26 vitamin D receptor Homo sapiens 82-100 17565270-5 2007 The vitamin D receptor, activated by vitamin D, does not directly bind to the negative vitamin D response elements, but instead associates with VDIR. Vitamin D 37-46 vitamin D receptor Homo sapiens 4-22 17565270-7 2007 SUMMARY: Histone inactivation induced by histone deacetylase co-repressors appears to facilitate vitamin D-induced transcriptional repression via the vitamin D receptor. Vitamin D 97-106 vitamin D receptor Homo sapiens 150-168 17565270-8 2007 Following vitamin D binding, structural alteration of the DNA-unbound vitamin D receptor triggers transcriptional repression. Vitamin D 10-19 vitamin D receptor Homo sapiens 70-88 17592215-2 2007 The single nucleotide polymorphisms (SNP) in vitamin D receptor (VDR) gene which can influence the affinity of vitamin D(3) to its receptor may be related to neurodegenerative diseases and neuronal damage by altering the vitamin D-mediated pathways. Vitamin D 45-54 vitamin D receptor Homo sapiens 65-68 17609203-1 2007 Atrichia with papular lesions (APL) and hereditary vitamin D-resistant rickets have a similar congenital hair loss disorder caused by mutations in hairless (HR) and vitamin D receptor (VDR) genes, respectively. Vitamin D 51-60 vitamin D receptor Homo sapiens 165-183 17609203-1 2007 Atrichia with papular lesions (APL) and hereditary vitamin D-resistant rickets have a similar congenital hair loss disorder caused by mutations in hairless (HR) and vitamin D receptor (VDR) genes, respectively. Vitamin D 51-60 vitamin D receptor Homo sapiens 185-188 17641030-5 2007 B cells expressed mRNAs for proteins involved in vitamin D activity, including 1 alpha-hydroxylase, 24-hydroxylase, and the vitamin D receptor, each of which was regulated by 1,25(OH)(2)D(3) and/or activation. Vitamin D 49-58 vitamin D receptor Homo sapiens 124-142 17592215-2 2007 The single nucleotide polymorphisms (SNP) in vitamin D receptor (VDR) gene which can influence the affinity of vitamin D(3) to its receptor may be related to neurodegenerative diseases and neuronal damage by altering the vitamin D-mediated pathways. Vitamin D 111-120 vitamin D receptor Homo sapiens 45-63 17592215-2 2007 The single nucleotide polymorphisms (SNP) in vitamin D receptor (VDR) gene which can influence the affinity of vitamin D(3) to its receptor may be related to neurodegenerative diseases and neuronal damage by altering the vitamin D-mediated pathways. Vitamin D 111-120 vitamin D receptor Homo sapiens 65-68 17130524-7 2007 In addition, nuclear receptor cofactors NCoR1 and SRC1 that could potentially affect VDR action were also low in both MDA-MB231 and S30 cells in comparison with ER-positive, vitamin D-sensitive BT474 cells. Vitamin D 174-183 vitamin D receptor Homo sapiens 85-88 17440943-1 2007 BACKGROUND: The vitamin D receptor (VDR) is required for actions of vitamin D. Vitamin D 16-25 vitamin D receptor Homo sapiens 36-39 17383948-0 2007 Re: "The positive effect of dietary vitamin D intake on bone mineral density in men is modulated by the polyadenosine repeat polymorphism of the vitamin D receptor" by Michaelsson et al. Vitamin D 36-45 vitamin D receptor Homo sapiens 145-163 17371163-5 2007 INTRODUCTION: Vitamin D plays an essential role in skeletal metabolism by binding to its nuclear steroid receptor, the vitamin D receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 119-137 17371163-5 2007 INTRODUCTION: Vitamin D plays an essential role in skeletal metabolism by binding to its nuclear steroid receptor, the vitamin D receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 139-142 17408240-2 2007 The vitamin D-induced protein-protein interactions between VDR and fluorophore (Cy3 or Cy5)-labeled TIF2 or SRC-1 were successfully detected by using a new HCHO fixing method of the protein complex on microplates. Vitamin D 4-13 vitamin D receptor Homo sapiens 59-62 17556530-9 2007 Paradoxically, mutations in the VDR ligand-dependent transcriptional activation function-2 that abrogate vitD3-dependent stimulation through classical vitamin D response elements, do not reduce vitD3-mediated LTR transactivation. Vitamin D 151-160 vitamin D receptor Homo sapiens 32-35 17507731-2 2007 More extensive roles for vitamin D were suggested by the discovery of the vitamin D receptor (VDR) in tissues that are not involved in calcium and phosphate metabolism. Vitamin D 25-34 vitamin D receptor Homo sapiens 74-92 17507731-2 2007 More extensive roles for vitamin D were suggested by the discovery of the vitamin D receptor (VDR) in tissues that are not involved in calcium and phosphate metabolism. Vitamin D 25-34 vitamin D receptor Homo sapiens 94-97 17393546-4 2007 Here, we describe the synthesis and in vitro assessment of a photocaged VDR agonist specific to a mutant NHR that is associated with vitamin D-resistant rickets. Vitamin D 133-142 vitamin D receptor Homo sapiens 72-75 17408240-3 2007 The results obtained from this screening of our synthetic vitamin D analogues suggest that the CoA-recruiting activities play an important role in determining the biological activity of various vitamin D analogues and explain the discrepancies between the VDR binding affinity and their biological activity. Vitamin D 58-67 vitamin D receptor Homo sapiens 256-259 17408240-3 2007 The results obtained from this screening of our synthetic vitamin D analogues suggest that the CoA-recruiting activities play an important role in determining the biological activity of various vitamin D analogues and explain the discrepancies between the VDR binding affinity and their biological activity. Vitamin D 194-203 vitamin D receptor Homo sapiens 256-259 17130524-8 2007 These results suggest that in addition to the increased ER and VDR expression, the intact VDR signaling machinery as present in ER-positive, vitamin D-sensitive cells is essential for the antiproliferative action of vitamin D, whereas the direct VDR target genes such as CYP24 can remain responsive to augmented VDR expression. Vitamin D 141-150 vitamin D receptor Homo sapiens 90-93 17130524-8 2007 These results suggest that in addition to the increased ER and VDR expression, the intact VDR signaling machinery as present in ER-positive, vitamin D-sensitive cells is essential for the antiproliferative action of vitamin D, whereas the direct VDR target genes such as CYP24 can remain responsive to augmented VDR expression. Vitamin D 141-150 vitamin D receptor Homo sapiens 90-93 17130524-8 2007 These results suggest that in addition to the increased ER and VDR expression, the intact VDR signaling machinery as present in ER-positive, vitamin D-sensitive cells is essential for the antiproliferative action of vitamin D, whereas the direct VDR target genes such as CYP24 can remain responsive to augmented VDR expression. Vitamin D 141-150 vitamin D receptor Homo sapiens 90-93 17130524-8 2007 These results suggest that in addition to the increased ER and VDR expression, the intact VDR signaling machinery as present in ER-positive, vitamin D-sensitive cells is essential for the antiproliferative action of vitamin D, whereas the direct VDR target genes such as CYP24 can remain responsive to augmented VDR expression. Vitamin D 216-225 vitamin D receptor Homo sapiens 90-93 17130524-8 2007 These results suggest that in addition to the increased ER and VDR expression, the intact VDR signaling machinery as present in ER-positive, vitamin D-sensitive cells is essential for the antiproliferative action of vitamin D, whereas the direct VDR target genes such as CYP24 can remain responsive to augmented VDR expression. Vitamin D 216-225 vitamin D receptor Homo sapiens 90-93 17130524-8 2007 These results suggest that in addition to the increased ER and VDR expression, the intact VDR signaling machinery as present in ER-positive, vitamin D-sensitive cells is essential for the antiproliferative action of vitamin D, whereas the direct VDR target genes such as CYP24 can remain responsive to augmented VDR expression. Vitamin D 216-225 vitamin D receptor Homo sapiens 90-93 16949543-1 2007 Vitamin D receptor (VDR) mediates a wide variety of vitamin D actions through transcriptional controls of target genes as a ligand-dependent transcription factor. Vitamin D 52-61 vitamin D receptor Homo sapiens 0-18 17325131-1 2007 The vitamin D receptor (VDR) mediates the biological actions of 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], the active form of vitamin D, which regulates calcium homeostasis, immunity, cellular differentiation, and other physiological processes. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 17325131-4 2007 These vitamin D derivatives bind to VDR but do not stabilize an active cofactor conformation. Vitamin D 6-15 vitamin D receptor Homo sapiens 36-39 17325131-9 2007 We examined the expression of endogenous VDR target genes and the nuclear protein levels of VDR and cofactors in several cell lines, including cells derived from intestine, bone, and monocytes, and found that the vitamin D(3) derivatives act as cell type-selective VDR modulators. Vitamin D 213-222 vitamin D receptor Homo sapiens 41-44 17325131-9 2007 We examined the expression of endogenous VDR target genes and the nuclear protein levels of VDR and cofactors in several cell lines, including cells derived from intestine, bone, and monocytes, and found that the vitamin D(3) derivatives act as cell type-selective VDR modulators. Vitamin D 213-222 vitamin D receptor Homo sapiens 92-95 17325131-9 2007 We examined the expression of endogenous VDR target genes and the nuclear protein levels of VDR and cofactors in several cell lines, including cells derived from intestine, bone, and monocytes, and found that the vitamin D(3) derivatives act as cell type-selective VDR modulators. Vitamin D 213-222 vitamin D receptor Homo sapiens 92-95 17078924-1 2007 Hereditary vitamin D resistant rickets (HVDRR) is caused by mutations in the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 77-95 17078924-1 2007 Hereditary vitamin D resistant rickets (HVDRR) is caused by mutations in the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 41-44 22461213-5 2007 Polymorphisms of VDR and ERalphaloci appear genetic determinants of their corresponding hormonal treatment response such as vitamin D and estrogens. Vitamin D 124-133 vitamin D receptor Homo sapiens 17-20 16949543-1 2007 Vitamin D receptor (VDR) mediates a wide variety of vitamin D actions through transcriptional controls of target genes as a ligand-dependent transcription factor. Vitamin D 52-61 vitamin D receptor Homo sapiens 20-23 17254542-9 2007 These studies suggest that the LxxLL motif can interact directly with the VDR and that this interaction is regulated by chemically diverse vitamin D ligands. Vitamin D 139-148 vitamin D receptor Homo sapiens 74-77 17371189-1 2007 Vitamin D(3) needs to be activated into 1,25-dihydroxyvitamin D(3) in order to bind to vitamin D receptor (VDR) for functional responses. Vitamin D 0-9 vitamin D receptor Homo sapiens 87-105 17115413-1 2007 Vitamin D analogs such as paricalcitol and calcitriol that activate the vitamin D receptor (VDR) provide survival benefit for Stage 5 chronic kidney disease (CKD) patients, possibly associated with a decrease in cardiovascular (CV)-related incidents. Vitamin D 0-9 vitamin D receptor Homo sapiens 72-90 17115413-1 2007 Vitamin D analogs such as paricalcitol and calcitriol that activate the vitamin D receptor (VDR) provide survival benefit for Stage 5 chronic kidney disease (CKD) patients, possibly associated with a decrease in cardiovascular (CV)-related incidents. Vitamin D 0-9 vitamin D receptor Homo sapiens 92-95 17371189-1 2007 Vitamin D(3) needs to be activated into 1,25-dihydroxyvitamin D(3) in order to bind to vitamin D receptor (VDR) for functional responses. Vitamin D 0-9 vitamin D receptor Homo sapiens 107-110 17302875-10 2007 CONCLUSION: The results support the idea that a non-1alpha-hydroxylated vitamin D analogue may elicit vitamin D receptor (VDR) effects in 1alpha-hydroxylase expressing parathyroid tumour cells. Vitamin D 72-81 vitamin D receptor Homo sapiens 102-120 17082781-1 2007 It has long been known that the active metabolite of vitamin D, 1,25 dihydroxyvitamin D(3), stimulates differentiation and inhibits proliferation in epidermal keratinocytes through interaction with the vitamin D receptor (VDR). Vitamin D 53-62 vitamin D receptor Homo sapiens 202-220 17082781-1 2007 It has long been known that the active metabolite of vitamin D, 1,25 dihydroxyvitamin D(3), stimulates differentiation and inhibits proliferation in epidermal keratinocytes through interaction with the vitamin D receptor (VDR). Vitamin D 53-62 vitamin D receptor Homo sapiens 222-225 17082781-2 2007 VDR functions through the coordinate binding of vitamin D response elements in the DNA and specific coactivator proteins which help to initiate transcription. Vitamin D 48-57 vitamin D receptor Homo sapiens 0-3 17302875-10 2007 CONCLUSION: The results support the idea that a non-1alpha-hydroxylated vitamin D analogue may elicit vitamin D receptor (VDR) effects in 1alpha-hydroxylase expressing parathyroid tumour cells. Vitamin D 72-81 vitamin D receptor Homo sapiens 122-125 17204417-0 2007 Extracellular calcium is a direct effecter of VDR levels in proximal tubule epithelial cells that counter-balances effects of PTH on renal Vitamin D metabolism. Vitamin D 139-148 vitamin D receptor Homo sapiens 46-49 17234401-0 2007 Controlling the chromatin organization of vitamin D target genes by multiple vitamin D receptor binding sites. Vitamin D 42-51 vitamin D receptor Homo sapiens 77-95 17223545-6 2007 The results identify new features of vitamin D-regulated enhancers, including their locations at gene loci, the structure of the VDR binding sites located within, their modular nature and their functional activity. Vitamin D 37-46 vitamin D receptor Homo sapiens 129-132 17257828-10 2007 Defining the role of hormone D-VDR binding will lead to a better understanding of the vitamin D signal transduction pathway. Vitamin D 86-95 vitamin D receptor Homo sapiens 31-34 17218095-1 2007 Binding of 1alpha,25-dihydroxy Vitamin D3 to the C-terminal domain (LBD) of its receptor (VDR), induces a conformational change that enables interaction of VDR with transcriptional coactivators such as the members of the p160/SRC family or the DRIP (Vitamin D interacting complex)/Mediator complex. Vitamin D 31-40 vitamin D receptor Homo sapiens 90-93 17218095-1 2007 Binding of 1alpha,25-dihydroxy Vitamin D3 to the C-terminal domain (LBD) of its receptor (VDR), induces a conformational change that enables interaction of VDR with transcriptional coactivators such as the members of the p160/SRC family or the DRIP (Vitamin D interacting complex)/Mediator complex. Vitamin D 31-40 vitamin D receptor Homo sapiens 156-159 17368177-0 2007 New insights into Vitamin D sterol-VDR proteolysis, allostery, structure-function from the perspective of a conformational ensemble model. Vitamin D 18-27 vitamin D receptor Homo sapiens 35-38 17254776-1 2007 Since the discovery of the Vitamin D receptor (VDR) in mammary cells, the role of the Vitamin D signaling pathway in normal glandular function and in breast cancer has been extensively explored. Vitamin D 27-36 vitamin D receptor Homo sapiens 47-50 17368177-1 2007 Recently, we have developed a Vitamin D sterol (VDS)-VDR conformational ensemble model. Vitamin D 30-39 vitamin D receptor Homo sapiens 53-56 16950800-10 2007 This study suggests a possible role of the polymorphisms in MTHFR and VDR interacting with dietary intakes of folate and vitamin D in skin cancer development, especially for SCC. Vitamin D 121-130 vitamin D receptor Homo sapiens 70-73 17388667-2 2007 Circulating 25-hydroxyvitamin D3 (25[OH]D), the most commonly used index of vitamin D status, is converted to the active hormone 1,25 dihydroxyvitamin D3 (1,25[OH]2D), which, operating through the vitamin D receptor (VDR), inhibits in vitro cell proliferation, induces differentiation and apoptosis, and may protect against prostate cancer. Vitamin D 22-31 vitamin D receptor Homo sapiens 197-215 17388667-2 2007 Circulating 25-hydroxyvitamin D3 (25[OH]D), the most commonly used index of vitamin D status, is converted to the active hormone 1,25 dihydroxyvitamin D3 (1,25[OH]2D), which, operating through the vitamin D receptor (VDR), inhibits in vitro cell proliferation, induces differentiation and apoptosis, and may protect against prostate cancer. Vitamin D 22-31 vitamin D receptor Homo sapiens 217-220 17388667-4 2007 Few studies have explored the joint association of circulating vitamin D levels with VDR polymorphisms. Vitamin D 63-72 vitamin D receptor Homo sapiens 85-88 17388667-16 2007 Moreover, vitamin D status, measured by 25(OH)D in plasma, interacts with the VDR FokI polymorphism and modifies prostate cancer risk. Vitamin D 10-19 vitamin D receptor Homo sapiens 78-81 16990805-1 2007 Sunlight causes DNA damage but also induces production of vitamin D whose metabolite 1,25-(OH)2D3 has antiproliferative and pro-differentiative effects in both melanocytes and cutaneous melanoma (CM) cells mediated through the vitamin D receptor (VDR). Vitamin D 58-67 vitamin D receptor Homo sapiens 227-245 16990805-1 2007 Sunlight causes DNA damage but also induces production of vitamin D whose metabolite 1,25-(OH)2D3 has antiproliferative and pro-differentiative effects in both melanocytes and cutaneous melanoma (CM) cells mediated through the vitamin D receptor (VDR). Vitamin D 58-67 vitamin D receptor Homo sapiens 247-250 17095575-2 2007 We have previously reported a novel class of negative vitamin D response element (nVDRE) called 1alphanVDRE in the human 25(OH)D31alpha-hydroxylase [1alpha(OH)ase] gene by 1alpha,25(OH)2D3-bound VDR. Vitamin D 54-63 vitamin D receptor Homo sapiens 83-86 18067661-1 2007 INTRODUCTION: The involvement of vitamin D receptor (VDR), which is a key mediator in the vitamin D pathway, in breast cancer etiology has long been of interest. Vitamin D 33-42 vitamin D receptor Homo sapiens 53-56 17121851-1 2007 Vitamin D receptor (VDR) is a ligand-dependent transcription factor that mediates vitamin D(3)-induced gene expression. Vitamin D 82-91 vitamin D receptor Homo sapiens 0-18 17121851-1 2007 Vitamin D receptor (VDR) is a ligand-dependent transcription factor that mediates vitamin D(3)-induced gene expression. Vitamin D 82-91 vitamin D receptor Homo sapiens 20-23 17121851-10 2007 Existence of the non-classical VDR pathway was suggested by a requirement of both c-Jun and VDR in stress-induced VDR activity and further demonstrated by VDR inhibiting c-Jun-dependent cell death independent of its classical transcriptional activity and independent of vitamin D(3). Vitamin D 270-279 vitamin D receptor Homo sapiens 31-34 17121851-11 2007 c-Jun is also required for vitamin D(3)-induced classical VDR transcriptional activity by a mechanism likely involving physical interactions between c-Jun and VDR proteins. Vitamin D 27-36 vitamin D receptor Homo sapiens 58-61 17121851-11 2007 c-Jun is also required for vitamin D(3)-induced classical VDR transcriptional activity by a mechanism likely involving physical interactions between c-Jun and VDR proteins. Vitamin D 27-36 vitamin D receptor Homo sapiens 159-162 17914260-2 2007 Vitamin D is a fat-soluble steroid hormone that interacts with its nuclear receptor (VDR) to regulate a variety of biological processes, such as bone metabolism, immune response modulation and transcription of several genes involved in CKD and PD disease mechanisms. Vitamin D 0-9 vitamin D receptor Homo sapiens 85-88 17106204-0 2007 Vitamin D receptor polymorphisms in hypocalcemic vitamin D-resistant rickets carriers. Vitamin D 49-58 vitamin D receptor Homo sapiens 0-18 18220741-1 2007 1alpha,25-Dihydroxyvitamin D(3) [1,25-(OH)(2)D(3)], the most active metabolite of vitamin D, exerts its biological effects by binding to a specific intracellular receptor (the vitamin D receptor, VDR) present in target cells. Vitamin D 19-28 vitamin D receptor Homo sapiens 196-199 17106204-9 2007 CONCLUSIONS: Our findings showed that the apparently healthy HVDRR carriers present a different distribution of BsmI and TaqI VDR polymorphisms than their controls, suggesting that further investigation of the HVDRR carrier population may elucidate the implication of VDR alleles in VDR function and the vitamin D endocrine system. Vitamin D 304-313 vitamin D receptor Homo sapiens 62-65 17003089-1 2006 CONTEXT: The vitamin D receptor gene (VDR) is a compelling candidate tumor suppressor gene for parathyroid adenomas based on existing evidence of the vitamin D system"s antiproliferative actions in parathyroid and other tissues, its reported inhibition of PTH gene transcription, and the decreased expression of VDR mRNA and VDR protein observed in parathyroid adenomas. Vitamin D 13-22 vitamin D receptor Homo sapiens 38-41 17237289-4 2007 This study examines the potential synergistic effect of SPARC and vitamin D, which up-regulates VDR, in enhancing chemotherapy response in colorectal cancer. Vitamin D 66-75 vitamin D receptor Homo sapiens 96-99 17507873-1 2007 Isoflavonoids exert a regulatory function on the expression of cytochrome P450 enzymes and also up-regulate the vitamin D(3) receptor (VDR) on cancer cells, which increase their sensitivity to 1,25-dihydroxyvitamin D(3) , the hormonally active form of vitamin D(3) . Vitamin D 112-121 vitamin D receptor Homo sapiens 135-138 17071612-1 2006 Clinically apparent hereditary vitamin D-resistant rickets (HVDRR) usually results from a loss of function mutation in the vitamin D receptor (VDR). Vitamin D 31-40 vitamin D receptor Homo sapiens 123-141 17071612-1 2006 Clinically apparent hereditary vitamin D-resistant rickets (HVDRR) usually results from a loss of function mutation in the vitamin D receptor (VDR). Vitamin D 31-40 vitamin D receptor Homo sapiens 61-64 17071612-5 2006 When overexpressed in vitamin D-responsive cells, cDNAs for both hnRNPC1 and hnRNPC2 inhibited VDR-VDRE-directed transactivation (28 and 43%, respectively; both p < 0.005). Vitamin D 22-31 vitamin D receptor Homo sapiens 95-98 17071612-7 2006 Chromatin immunoprecipitation of nucleoproteins bound to the transcriptionally active 1,25-dihydroxy vitamin D-driven CYP24 promoter revealed the presence of REBiP in vitamin D-responsive human cells and indicated that the normal pattern of 1,25-dihydroxy vitamin D-initiated cyclical movement of the VDR on and off the VDRE is legislated by competitive, reciprocal occupancy of the VDRE by hnRNP C1/C2. Vitamin D 101-110 vitamin D receptor Homo sapiens 301-304 16860619-0 2006 The positive effect of dietary vitamin D intake on bone mineral density in men is modulated by the polyadenosine repeat polymorphism of the vitamin D receptor. Vitamin D 31-40 vitamin D receptor Homo sapiens 140-158 16860619-10 2006 However, the positive association between vitamin D intake and BMD was especially apparent among those with the L/L polyadenosine (A) VDR genotype explaining between 10 and 15% of the variability in BMD depending on site (p < 0.004). Vitamin D 42-51 vitamin D receptor Homo sapiens 134-137 16860619-13 2006 CONCLUSIONS: Our results indicate that the extent of positive association between dietary vitamin D intake and BMD in men is dependent on VDR polymorphism, a novel conceivable important gene-environmental interaction. Vitamin D 90-99 vitamin D receptor Homo sapiens 138-141 16946007-4 2006 The discovery in 1969 of the nuclear vitamin D receptor (VDR) for 1alpha,25(OH)2D3 initiated a two-decade-long proliferation of reports that collectively described the broad sphere of influence of the vitamin D endocrine system that is defined by the presence of the VDR in over 30 tissue/organs of man. Vitamin D 37-46 vitamin D receptor Homo sapiens 57-60 16946007-4 2006 The discovery in 1969 of the nuclear vitamin D receptor (VDR) for 1alpha,25(OH)2D3 initiated a two-decade-long proliferation of reports that collectively described the broad sphere of influence of the vitamin D endocrine system that is defined by the presence of the VDR in over 30 tissue/organs of man. Vitamin D 37-46 vitamin D receptor Homo sapiens 267-270 17003089-1 2006 CONTEXT: The vitamin D receptor gene (VDR) is a compelling candidate tumor suppressor gene for parathyroid adenomas based on existing evidence of the vitamin D system"s antiproliferative actions in parathyroid and other tissues, its reported inhibition of PTH gene transcription, and the decreased expression of VDR mRNA and VDR protein observed in parathyroid adenomas. Vitamin D 13-22 vitamin D receptor Homo sapiens 312-315 17003089-1 2006 CONTEXT: The vitamin D receptor gene (VDR) is a compelling candidate tumor suppressor gene for parathyroid adenomas based on existing evidence of the vitamin D system"s antiproliferative actions in parathyroid and other tissues, its reported inhibition of PTH gene transcription, and the decreased expression of VDR mRNA and VDR protein observed in parathyroid adenomas. Vitamin D 13-22 vitamin D receptor Homo sapiens 312-315 16732322-6 2006 Most importantly, we have identified a vitamin D responsive element (VDRE) in the promoter region of the human KSR-1 gene, to which VDR binds in a 1,25D-dependent manner, in vitro and in vivo. Vitamin D 39-48 vitamin D receptor Homo sapiens 69-72 17156732-5 2006 In vitamin D target organs, inactivation of vitamin D is attributed to CYP24A1 which is transcriptionally induced by 1,25(OH)2D3 whose action is mediated by binding to its cognate nuclear receptor, the vitamin D receptor (VDR). Vitamin D 3-12 vitamin D receptor Homo sapiens 202-220 17156732-5 2006 In vitamin D target organs, inactivation of vitamin D is attributed to CYP24A1 which is transcriptionally induced by 1,25(OH)2D3 whose action is mediated by binding to its cognate nuclear receptor, the vitamin D receptor (VDR). Vitamin D 3-12 vitamin D receptor Homo sapiens 222-225 17156732-5 2006 In vitamin D target organs, inactivation of vitamin D is attributed to CYP24A1 which is transcriptionally induced by 1,25(OH)2D3 whose action is mediated by binding to its cognate nuclear receptor, the vitamin D receptor (VDR). Vitamin D 44-53 vitamin D receptor Homo sapiens 202-220 17156732-5 2006 In vitamin D target organs, inactivation of vitamin D is attributed to CYP24A1 which is transcriptionally induced by 1,25(OH)2D3 whose action is mediated by binding to its cognate nuclear receptor, the vitamin D receptor (VDR). Vitamin D 44-53 vitamin D receptor Homo sapiens 222-225 16563362-4 2006 Expression and nuclear activation of the vitamin D receptor (VDR) are necessary for the effects of vitamin D. Vitamin D 41-50 vitamin D receptor Homo sapiens 61-64 17002582-16 2006 CONCLUSIONS: Duodenal TRPV6 expression is vitamin D dependent in men, but not in older women, where expression of TRPV6 and VDR are both reduced. Vitamin D 42-51 vitamin D receptor Homo sapiens 124-127 17086935-1 2006 1alpha,25-Dihydroxyvitamin D3 (1,25-(OH)2D3), the biologically active metabolite of vitamin D, mediates its actions via the vitamin D receptor (VDR), a member of the superfamily of steroid/thyroid hormone/retinoid receptors. Vitamin D 19-28 vitamin D receptor Homo sapiens 124-142 17086935-1 2006 1alpha,25-Dihydroxyvitamin D3 (1,25-(OH)2D3), the biologically active metabolite of vitamin D, mediates its actions via the vitamin D receptor (VDR), a member of the superfamily of steroid/thyroid hormone/retinoid receptors. Vitamin D 19-28 vitamin D receptor Homo sapiens 144-147 17086935-5 2006 In order to identify VDR ligands with less hypercalcemia liability, a number of pharmaceutical companies are pursuing efforts to develop synthetic vitamin D analogs. Vitamin D 147-156 vitamin D receptor Homo sapiens 21-24 17086935-7 2006 The future directions of vitamin D research for the discovery of novel VDR agonists for osteoporosis are also discussed. Vitamin D 25-34 vitamin D receptor Homo sapiens 71-74 16362385-6 2006 We thus conclude that ER and VDR genes may contribute to lumbar spondylosis in a distinct manner: estrogen sensitivity influences the severity in the early phase after menopause while vitamin D plays an important role at older ages when the contribution of estrogen loss is weaker. Vitamin D 184-193 vitamin D receptor Homo sapiens 29-32 16806146-2 2006 BACKGROUND: Vitamin D receptor (VDR) mediates the effects of vitamin D. Vitamin D 61-70 vitamin D receptor Homo sapiens 12-30 16936639-4 2006 This study shows that, in VDR/RXR heterodimers, allosteric communication triggered by the RXR ligand has a previously unrecognized role in vitamin D signalling, with important physiological and therapeutic implications. Vitamin D 139-148 vitamin D receptor Homo sapiens 26-29 16806146-2 2006 BACKGROUND: Vitamin D receptor (VDR) mediates the effects of vitamin D. Vitamin D 61-70 vitamin D receptor Homo sapiens 32-35 16883034-3 2006 Vitamin D deficiency/insensitivity induces type 2 diabetes through impaired insulin secretion involving VDR on pancreatic beta cells, as well as type 1 diabetes through the reduction in immuno-modulatory action of 1,25 (OH)(2) vitamin D. Vitamin D 0-9 vitamin D receptor Homo sapiens 104-107 16598763-5 2006 Transfection studies in CaCo-2 cells with a vitamin D response element-containing construct revealed the involvement of the VDR in this UVB-dependent CYP24 induction. Vitamin D 44-53 vitamin D receptor Homo sapiens 124-127 17551468-0 2006 Vitamin D receptor defects: the story of hereditary resistance to vitamin D. Vitamin D 66-75 vitamin D receptor Homo sapiens 0-18 16835013-1 2006 The nuclear receptor for Vitamin D (VDR) mediates many of the effects of Vitamin D in target tissues by regulating gene expression. Vitamin D 25-34 vitamin D receptor Homo sapiens 36-39 16835013-1 2006 The nuclear receptor for Vitamin D (VDR) mediates many of the effects of Vitamin D in target tissues by regulating gene expression. Vitamin D 73-82 vitamin D receptor Homo sapiens 36-39 16603671-7 2006 When aortic rings from normal rats or a primary culture of human coronary artery smooth muscle cells were treated with phosphorus or vitamin D analogs in vitro, high phosphorus induced calcium accumulation and/or 45Ca uptake in a dose- or time-dependent manner, whereas vitamin D analogs including 1alpha(OH)D2 up to 100 nM had no significant effect despite the presence of a functional vitamin D receptor. Vitamin D 133-142 vitamin D receptor Homo sapiens 387-405 16886688-3 2006 MATERIALS AND METHODS: Vitamin D receptor (VDR)- positive MCF-7 cells in culture were stimulated with the vitamin D metabolites vitamin D3, 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 for 24, 48; 72 and 96 hours in physiological and supraphysiological concentrations. Vitamin D 106-115 vitamin D receptor Homo sapiens 23-41 16886688-3 2006 MATERIALS AND METHODS: Vitamin D receptor (VDR)- positive MCF-7 cells in culture were stimulated with the vitamin D metabolites vitamin D3, 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 for 24, 48; 72 and 96 hours in physiological and supraphysiological concentrations. Vitamin D 106-115 vitamin D receptor Homo sapiens 43-46 16624609-7 2006 In this brief review, the role of vitamin D activation through its vitamin D receptor will serve as an introduction to the magnitude of the nutritional deficits in children, adults, and those with CKD. Vitamin D 34-43 vitamin D receptor Homo sapiens 67-85 16957418-1 2006 The active form of vitamin D, 1,25-dihydroxyvitamin D3, is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the superfamily of nuclear receptors, and exerts a number of diverse biological functions. Vitamin D 19-28 vitamin D receptor Homo sapiens 99-117 16957418-1 2006 The active form of vitamin D, 1,25-dihydroxyvitamin D3, is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the superfamily of nuclear receptors, and exerts a number of diverse biological functions. Vitamin D 19-28 vitamin D receptor Homo sapiens 119-122 16750418-2 2006 We analyzed vitamin D receptor (VDR) binding to putative vitamin D response elements within the 5-LO promoter and analyzed its function by reporter gene analysis. Vitamin D 12-21 vitamin D receptor Homo sapiens 32-35 16753019-2 2006 Transfection studies suggest dissociated effects of VDR gene mutations on the regulation of genes involved in vitamin D metabolism and dendritic cell maturation. Vitamin D 110-119 vitamin D receptor Homo sapiens 52-55 16753019-4 2006 MATERIALS AND METHODS: The VDR gene was analyzed in a child with vitamin D-resistant rickets, total alopecia, and early childhood-onset type 1 diabetes. Vitamin D 65-74 vitamin D receptor Homo sapiens 27-30 16753019-0 2006 Vitamin D-resistant rickets and type 1 diabetes in a child with compound heterozygous mutations of the vitamin D receptor (L263R and R391S): dissociated responses of the CYP-24 and rel-B promoters to 1,25-dihydroxyvitamin D3. Vitamin D 0-9 vitamin D receptor Homo sapiens 103-121 16596260-1 2006 The parathormone (PTH) production is controlled by calcium and vitamin D, which interact with the calcium-sensing receptor (CaSR) and vitamin D receptor (VDR), respectively. Vitamin D 63-72 vitamin D receptor Homo sapiens 134-152 16753019-1 2006 UNLABELLED: We report here the first association between vitamin D-resistant rickets, alopecia, and type 1 diabetes in a child with compound heterozygous mutations in the VDR gene. Vitamin D 57-66 vitamin D receptor Homo sapiens 171-174 16735766-1 2006 The aim of this study was to compare the bone mineral density (BMD) of two different treatment regimens in infants with nutritional vitamin D deficient rickets (VDR). Vitamin D 132-141 vitamin D receptor Homo sapiens 161-164 16596260-1 2006 The parathormone (PTH) production is controlled by calcium and vitamin D, which interact with the calcium-sensing receptor (CaSR) and vitamin D receptor (VDR), respectively. Vitamin D 63-72 vitamin D receptor Homo sapiens 154-157 16618780-4 2006 We also identified a putative positive vitamin D response element within the MKP5 promoter that associated with the vitamin D receptor following 1,25D treatment. Vitamin D 39-48 vitamin D receptor Homo sapiens 116-134 16365879-3 2006 In addition, epidermal keratinocytes contain the vitamin D receptor (VDR) and possess 25-hydroxylase and 1alpha-hydroxylase activity indicating that all components of the vitamin D system are present. Vitamin D 49-58 vitamin D receptor Homo sapiens 69-72 16365879-6 2006 Transfection experiments with a vitamin D response element containing construct confirmed VDR-dependent gene activation. Vitamin D 32-41 vitamin D receptor Homo sapiens 90-93 16483768-6 2006 Examination of the regulation of VDR target gene mRNA in DU-145 cells revealed that co-treatment of 1,25-(OH)(2)D(3) plus inhibitor of Vitamin D(3) metabolising enzymes co-ordinately upregulated CYP24, p21(waf1/cip1) and GADD45alpha. Vitamin D 135-144 vitamin D receptor Homo sapiens 33-36 16614118-1 2006 Inherited variants of the vitamin D receptor (VDR) gene may influence cancer risk by altering the effect of vitamin D on cell growth and homeostasis. Vitamin D 26-35 vitamin D receptor Homo sapiens 46-49 16549446-6 2006 In support of this suggestion, both 1alpha,25(OH)2D3 and 25(OH)D3 transactivated VDR in HMEC cultures, as measured by induction of a vitamin D responsive reporter gene and upregulation of CYP24, an endogenous VDR target gene. Vitamin D 133-142 vitamin D receptor Homo sapiens 81-84 16357103-3 2006 1alpha,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] induces SULT2A1 gene transcription after the recruitment of VDR to the vitamin D-responsive chromatin region of SULT2A1. Vitamin D 19-28 vitamin D receptor Homo sapiens 105-108 16357103-5 2006 This element combines a VDR/retinoid X receptor-alpha-binding site [vitamin D response element (VDRE)], which is an imperfect inverted repeat 2 of AGCTCA, and a CAAT/enhancer binding protein (C/EBP)-binding site located 9 bp downstream to VDRE. Vitamin D 68-77 vitamin D receptor Homo sapiens 24-27 16406653-1 2006 Vitamin D signaling is dependent on the availability and turnover of the active Vitamin D receptor (VDR) ligand 1,25-dihydroxycholecalciferol and on the efficiency of VDR transactivation. Vitamin D 0-9 vitamin D receptor Homo sapiens 80-98 16406653-1 2006 Vitamin D signaling is dependent on the availability and turnover of the active Vitamin D receptor (VDR) ligand 1,25-dihydroxycholecalciferol and on the efficiency of VDR transactivation. Vitamin D 0-9 vitamin D receptor Homo sapiens 100-103 16406653-1 2006 Vitamin D signaling is dependent on the availability and turnover of the active Vitamin D receptor (VDR) ligand 1,25-dihydroxycholecalciferol and on the efficiency of VDR transactivation. Vitamin D 0-9 vitamin D receptor Homo sapiens 167-170 16517748-8 2006 The basal IL-18 expression and activity were much higher in VDR(-/-) keratinocytes and skin, underscoring the importance of the repressive role of vitamin D in IL-18 production. Vitamin D 147-156 vitamin D receptor Homo sapiens 60-63 16609009-6 2006 Combinations of vitamin D(3) compounds with TSA restored VDR antiproliferative signaling (target gene regulation, cell cycle arrest, and antiproliferative effects in liquid culture) to levels which were indistinguishable from MCF-12A cells. Vitamin D 16-25 vitamin D receptor Homo sapiens 57-60 16690532-1 2006 Although vitamin D analogs are known to induce the differentiation of the HL-60 promyelocytic leukemia cells, the effect of vitamin D analogs on the distribution of vitamin D receptor (VDR) in these cells is not well studied. Vitamin D 124-133 vitamin D receptor Homo sapiens 165-183 16690532-1 2006 Although vitamin D analogs are known to induce the differentiation of the HL-60 promyelocytic leukemia cells, the effect of vitamin D analogs on the distribution of vitamin D receptor (VDR) in these cells is not well studied. Vitamin D 124-133 vitamin D receptor Homo sapiens 185-188 16690532-6 2006 These results suggest that binding of vitamin D analogs to VDR induced receptor translocation into the nucleus, which stabilizes the receptor, resulting in an accumulation of the VDR protein. Vitamin D 38-47 vitamin D receptor Homo sapiens 59-62 16690532-6 2006 These results suggest that binding of vitamin D analogs to VDR induced receptor translocation into the nucleus, which stabilizes the receptor, resulting in an accumulation of the VDR protein. Vitamin D 38-47 vitamin D receptor Homo sapiens 179-182 16613705-1 2006 OBJECTIVE: To explore the genetic susceptibility of children to vitamin D deficiency rickets through studying the association between Vitamin D receptor (VDR) gene polymorphism and vitamin D deficiency rickets. Vitamin D 64-73 vitamin D receptor Homo sapiens 134-152 16613705-1 2006 OBJECTIVE: To explore the genetic susceptibility of children to vitamin D deficiency rickets through studying the association between Vitamin D receptor (VDR) gene polymorphism and vitamin D deficiency rickets. Vitamin D 64-73 vitamin D receptor Homo sapiens 154-157 16613705-1 2006 OBJECTIVE: To explore the genetic susceptibility of children to vitamin D deficiency rickets through studying the association between Vitamin D receptor (VDR) gene polymorphism and vitamin D deficiency rickets. Vitamin D 181-190 vitamin D receptor Homo sapiens 134-152 16613705-1 2006 OBJECTIVE: To explore the genetic susceptibility of children to vitamin D deficiency rickets through studying the association between Vitamin D receptor (VDR) gene polymorphism and vitamin D deficiency rickets. Vitamin D 181-190 vitamin D receptor Homo sapiens 154-157 16613705-10 2006 CONCLUSIONS: There is an association between the VDR gene Fok I polymorphism and vitamin D deficiency rickets. Vitamin D 81-90 vitamin D receptor Homo sapiens 49-52 16314444-5 2006 Expression of VDR and 1-alpha-hydroxylase in PTC may be compatible with an overall favorable prognosis for this tumor type and may constitute important prerequisites for using vitamin D and/or vitamin D analogs in the treatment of PTC. Vitamin D 176-185 vitamin D receptor Homo sapiens 14-17 16314444-5 2006 Expression of VDR and 1-alpha-hydroxylase in PTC may be compatible with an overall favorable prognosis for this tumor type and may constitute important prerequisites for using vitamin D and/or vitamin D analogs in the treatment of PTC. Vitamin D 193-202 vitamin D receptor Homo sapiens 14-17 16369193-4 2005 Actions of vitamin D are mediated by the binding of 1, 25-(OH)2D3 to a specific cytosolic/nuclear vitamin D receptor (VDR), a member of the steroid/thyroid hormone receptor superfamily. Vitamin D 11-20 vitamin D receptor Homo sapiens 98-116 16848738-1 2006 The vitamin D receptor (VDR) is an endocrine member of the nuclear receptor superfamily and binds the biologically most active vitamin D metabolite, 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3). Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 16269453-9 2006 Hr binding to the VDR was eliminated by 1,25(OH)2D3, which recruited the coactivator vitamin D receptor-interacting protein 205 (DRIP205) to the VDR/vitamin D response element complex. Vitamin D 85-94 vitamin D receptor Homo sapiens 18-21 16269453-9 2006 Hr binding to the VDR was eliminated by 1,25(OH)2D3, which recruited the coactivator vitamin D receptor-interacting protein 205 (DRIP205) to the VDR/vitamin D response element complex. Vitamin D 85-94 vitamin D receptor Homo sapiens 145-148 16424674-1 2006 BACKGROUND/AIMS: Hypocalcemic vitamin D-resistant rickets (HVDRR) is a rare monogenic autosomal recessive disorder associated with mutations in the gene of the vitamin D receptor (VDR), the mediator of 1,25(OH)2D3 action. Vitamin D 30-39 vitamin D receptor Homo sapiens 160-178 16424674-1 2006 BACKGROUND/AIMS: Hypocalcemic vitamin D-resistant rickets (HVDRR) is a rare monogenic autosomal recessive disorder associated with mutations in the gene of the vitamin D receptor (VDR), the mediator of 1,25(OH)2D3 action. Vitamin D 30-39 vitamin D receptor Homo sapiens 60-63 16002434-2 2005 The vitamin D receptor (VDR) is a ligand-regulated transcription factor that recognizes cognate vitamin D response elements (VDREs) formed by direct or everted repeats of PuG(G/T)TCA motifs separated by 3 or 6 bp (DR3 or ER6). Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 16181450-8 2005 The active form of vitamin D, 1,25-dihydroxyvitamin D(3), exhibits antiproliferative and immunoregulatory effects via the vitamin D receptor, and thus is successfully used in the topical treatment of psoriasis. Vitamin D 19-28 vitamin D receptor Homo sapiens 122-140 16046118-1 2005 1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the biologically active metabolite of Vitamin D(3), not only regulates bone and calcium metabolism but also exerts other biological activities, including immunomodulation via the nuclear Vitamin D receptor expressed in antigen-presenting cells and activated T cells. Vitamin D 84-93 vitamin D receptor Homo sapiens 233-251 16055325-5 2005 Along these lines we have recently proposed a Vitamin D sterol/VDR conformational ensemble model that posits the VDR contains two distinct, yet overlapping ligand binding sites, and that the potential differential stabilities of 1,25D and HL in these two pockets can be used to explain their different non-genomic signaling properties. Vitamin D 46-55 vitamin D receptor Homo sapiens 63-66 16055325-5 2005 Along these lines we have recently proposed a Vitamin D sterol/VDR conformational ensemble model that posits the VDR contains two distinct, yet overlapping ligand binding sites, and that the potential differential stabilities of 1,25D and HL in these two pockets can be used to explain their different non-genomic signaling properties. Vitamin D 46-55 vitamin D receptor Homo sapiens 113-116 16055325-9 2005 This model may provide new insights into how Vitamin D sterols that uncouple the unwanted hypercalcemic effect from attractive growth inhibitory/differentiation properties can do so by differentially stabilizing different subpopulations of VDR conformational ensemble members. Vitamin D 45-54 vitamin D receptor Homo sapiens 240-243 16213141-3 2006 Diamino 5 and 6 as well as monoamino 3, 4, 30, and 31 vitamin D(3) derivatives have shown poor binding to VDR compared with 1alpha,25-dihydroxyvitamin D(3). Vitamin D 54-63 vitamin D receptor Homo sapiens 106-109 16243370-3 2006 This effect is mediated via a negative Vitamin D response element (nVDREhPTHrP) within the human PTHrP gene and involves an interaction between nVDREhPTHrP and the Vitamin D receptor (VDR). Vitamin D 39-48 vitamin D receptor Homo sapiens 164-182 16243370-3 2006 This effect is mediated via a negative Vitamin D response element (nVDREhPTHrP) within the human PTHrP gene and involves an interaction between nVDREhPTHrP and the Vitamin D receptor (VDR). Vitamin D 39-48 vitamin D receptor Homo sapiens 68-71 16629532-2 2006 One risk factor is reported to be vitamin D (VD) and therefore the function of its receptor (VDR) could be of importance. Vitamin D 34-43 vitamin D receptor Homo sapiens 93-96 16958596-8 2006 Serum 25OH vitamin D levels, assessed in only 63 probands, were significantly associated with VDR genotypes (ANCOVA, p<or=0.0027). Vitamin D 11-20 vitamin D receptor Homo sapiens 94-97 16946620-1 2006 Mutations in vitamin D receptor (VDR) cause hereditary vitamin D resistant rickets (HVDRR). Vitamin D 13-22 vitamin D receptor Homo sapiens 33-36 16355284-2 2006 Here we studied five common polymorphisms of VDR in relation to calcium intake and vitamin D status in a population-based cohort of 3100 British women, but found no significant association with bone mass, bone loss, or fracture. Vitamin D 83-92 vitamin D receptor Homo sapiens 45-48 16374421-0 2006 Vitamin D in chronic kidney disease: a systemic role for selective vitamin D receptor activation. Vitamin D 0-9 vitamin D receptor Homo sapiens 67-85 17002490-1 2006 black triangle An oral formulation of paricalcitol has been developed for the prevention and treatment of secondary hyperparathyroidism in patients with stage 3 or 4 chronic kidney disease.black triangle Paricalcitol is a synthetic vitamin D analog that binds to the vitamin D receptor inducing suppression of parathyroid hormone (PTH) secretion.black triangle Oral paricalcitol was significantly more effective than placebo in treating secondary hyperparathyroidism in patients with stage 3 or 4 chronic kidney disease. Vitamin D 232-241 vitamin D receptor Homo sapiens 267-285 16202592-2 2005 The weighted holistic invariant molecular (WHIM) approach has been applied to the study of the VDR affinity of 86 vitamin D analogues. Vitamin D 114-123 vitamin D receptor Homo sapiens 95-98 16141393-9 2005 We theorize that the endogenous ATPase activity of hsc70 promotes the transfer of vitamin D sterols to other intracellular vitamin D binding proteins, such as the vitamin D receptor and vitamin D hydroxylases, to which hsc70 is known to bind. Vitamin D 82-91 vitamin D receptor Homo sapiens 163-181 16203744-2 2005 The transcriptional factors SNAIL and ZEB1 are involved in its repression, whereas activation of vitamin D receptor (VDR) by vitamin D induces its transcription. Vitamin D 97-106 vitamin D receptor Homo sapiens 117-120 16214913-2 2005 The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D and additionally interacts with other cell-signaling pathways that influence cancer development. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 16202933-9 2005 Vitamin D receptor is expressed in all calcium-regulated tissues, including the ovary; thus, calcium and vitamin D appear to be necessary for full ovarian function. Vitamin D 105-114 vitamin D receptor Homo sapiens 0-18 16278149-1 2005 OBJECTIVE: Vitamin D has been shown to exert multiple immunomodulatory effects and is known to suppress T-cell activation by binding to the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 140-158 16278149-1 2005 OBJECTIVE: Vitamin D has been shown to exert multiple immunomodulatory effects and is known to suppress T-cell activation by binding to the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 160-163 16369193-4 2005 Actions of vitamin D are mediated by the binding of 1, 25-(OH)2D3 to a specific cytosolic/nuclear vitamin D receptor (VDR), a member of the steroid/thyroid hormone receptor superfamily. Vitamin D 11-20 vitamin D receptor Homo sapiens 118-121 15650022-0 2005 Molecular mechanism of the vitamin D antagonistic actions of (23S)-25-dehydro-1alpha-hydroxyvitamin D3-26,23-lactone depends on the primary structure of the carboxyl-terminal region of the vitamin d receptor. Vitamin D 27-36 vitamin D receptor Homo sapiens 189-207 16059639-16 2005 CONCLUSION: Our study provides new insights into the mechanisms involved in the enhancement of VDR function by both phosphorylation and hexafluoro analogs and forms a basis for future study of vitamin D analogs or specifically designed kinase activity mediators as potential therapy for the treatment of selected patients with HVDRR. Vitamin D 193-202 vitamin D receptor Homo sapiens 95-98 15890672-2 2005 The most bioactive form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] elicits its effects by binding to the vitamin D receptor (VDR) and regulating the transcription of target genes. Vitamin D 27-36 vitamin D receptor Homo sapiens 116-134 15890672-2 2005 The most bioactive form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] elicits its effects by binding to the vitamin D receptor (VDR) and regulating the transcription of target genes. Vitamin D 27-36 vitamin D receptor Homo sapiens 136-139 20704880-7 2005 Also, certain genetic variations in components of the vitamin D system such as the vitamin D receptor (VDR) account for an increased risk for type 1 diabetes. Vitamin D 54-63 vitamin D receptor Homo sapiens 83-101 20704880-7 2005 Also, certain genetic variations in components of the vitamin D system such as the vitamin D receptor (VDR) account for an increased risk for type 1 diabetes. Vitamin D 54-63 vitamin D receptor Homo sapiens 103-106 15798098-7 2005 This review deals with the molecular aspects of noncalcemic actions of vitamin D analogs that account for the efficacy of VDR ligands in the above-mentioned indications. Vitamin D 71-80 vitamin D receptor Homo sapiens 122-125 15985530-5 2005 The induction occurred via a consensus vitamin D response element (VDRE) in the CAMP promoter that was bound by the vitamin D receptor (VDR). Vitamin D 39-48 vitamin D receptor Homo sapiens 116-134 15985530-5 2005 The induction occurred via a consensus vitamin D response element (VDRE) in the CAMP promoter that was bound by the vitamin D receptor (VDR). Vitamin D 39-48 vitamin D receptor Homo sapiens 67-70 16083553-1 2005 OBJECTIVE: To study the association between vitamin D receptor (VDR) gene Apa I polymorphism and vitamin D deficiency rickets in children of Shanxi Han ethnic group, and to explore the significance of individual hereditary factors in the development of rickets. Vitamin D 44-53 vitamin D receptor Homo sapiens 64-67 15992766-1 2005 The vitamin D receptor (VDR) mediates the effects of 1,25(OH)(2)D(3), the active form of vitamin D. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 16076355-5 2005 Vitamin D analogs with selective VDR activity (such as paricalcitol) have great potential for preventing parathyroid hyperplasia and bone loss in early CKD without adversely affecting kidney function. Vitamin D 0-9 vitamin D receptor Homo sapiens 33-36 15867263-3 2005 EXPERIMENTAL DESIGN: Quantitative reverse transcription-PCR analysis of mRNA expression was carried out for the vitamin D-activating enzyme 1alpha-hydroxylase, the catabolic enzyme 24-hydroxylase, and the vitamin D receptor in 41 tumors and paired nonneoplastic tissue as well as breast cancer cell lines. Vitamin D 112-121 vitamin D receptor Homo sapiens 205-223 15857747-1 2005 The hormonal form of vitamin D, 1alpha,25-dihydroxyvitamin D(3) (1,25D), generates many biological actions by interactions with its nuclear receptor (VDR). Vitamin D 21-30 vitamin D receptor Homo sapiens 150-153 15862832-7 2005 In addition, evidence that the model is consistent with the pH requirement for Vitamin D sterol-VDR crystallization will be presented. Vitamin D 79-88 vitamin D receptor Homo sapiens 96-99 15578590-4 2005 We also show that LCA-VDR stimulates transcription of gene reporter constructs containing DR3 and ER6 vitamin D responsive elements (VDREs) from the human CYP3A4 gene. Vitamin D 102-111 vitamin D receptor Homo sapiens 22-25 15891005-4 2005 Treatment with active vitamin D can increase vitamin D receptor expression, inhibit growth of parathyroid tumors, and reduce PTH levels in patients with hyperparathyroidism (HPT). Vitamin D 22-31 vitamin D receptor Homo sapiens 45-63 15664452-1 2005 1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the active form of Vitamin D, mediates gene transcription through the Vitamin D receptor (VDR), a nuclear receptor expressed in multiple normal and transformed cell types. Vitamin D 65-74 vitamin D receptor Homo sapiens 116-134 15709781-1 2005 The vitamin D receptor (VDR) is a ligand-responsive transcription factor that forms active, heterodimeric complexes with the 9-cis retinoic acid receptor (RXR) on vitamin D response elements (VDREs). Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 15683428-3 2005 Vitamin D has been shown to exert multiple immunomodulatory effects, which acts through its own receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 106-109 15664452-1 2005 1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the active form of Vitamin D, mediates gene transcription through the Vitamin D receptor (VDR), a nuclear receptor expressed in multiple normal and transformed cell types. Vitamin D 65-74 vitamin D receptor Homo sapiens 136-139 15589699-8 2005 The observed distribution of the VDR is consistent with the proposal that Vitamin D operates in a similar fashion to the known neurosteroids. Vitamin D 74-83 vitamin D receptor Homo sapiens 33-36 15733015-1 2005 Paricalcitol (Zemplar) is a synthetic vitamin D(2) analogue that inhibits the secretion of parathyroid hormone (PTH) through binding to the vitamin D receptor. Vitamin D 38-47 vitamin D receptor Homo sapiens 140-158 15659793-8 2004 Osteocalcin gene expression was enhanced by VD/VD-R through the vitamin D-responsive element in the promoter. Vitamin D 64-73 vitamin D receptor Homo sapiens 47-51 15630458-1 2005 Vitamin D controls calcium homeostasis and the development and maintenance of bones through vitamin D receptor activation. Vitamin D 0-9 vitamin D receptor Homo sapiens 92-110 15489543-1 2005 The vitamin D receptor (VDR), a member of the nuclear receptor superfamily, mediates the biological actions of the active form of vitamin D, 1alpha,25-dihydroxyvitamin D(3). Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 15589699-9 2005 The widespread distribution of 1alpha-OHase and the VDR suggests that Vitamin D may have autocrine/paracrine properties in the human brain. Vitamin D 70-79 vitamin D receptor Homo sapiens 52-55 15585794-1 2004 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3[, the biologically active form of vitamin D that interacts with the vitamin D receptor (VDR), is a coordinate regulator of proliferation, differentiation, and survival of breast cancer cells. Vitamin D 19-28 vitamin D receptor Homo sapiens 111-129 15585794-1 2004 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3[, the biologically active form of vitamin D that interacts with the vitamin D receptor (VDR), is a coordinate regulator of proliferation, differentiation, and survival of breast cancer cells. Vitamin D 19-28 vitamin D receptor Homo sapiens 131-134 15570014-1 2004 Vitamin D is a conditionally required nutrient traditionally thought to influence physiology as the metabolite 1,25-dihydroxyvitamin D [1,25(OH)(2) D] by binding to the vitamin D receptor (VDR) and stimulating the transcription of genes through direct VDR-DNA interactions. Vitamin D 0-9 vitamin D receptor Homo sapiens 169-187 15570014-1 2004 Vitamin D is a conditionally required nutrient traditionally thought to influence physiology as the metabolite 1,25-dihydroxyvitamin D [1,25(OH)(2) D] by binding to the vitamin D receptor (VDR) and stimulating the transcription of genes through direct VDR-DNA interactions. Vitamin D 0-9 vitamin D receptor Homo sapiens 189-192 15570056-12 2004 These cells have normal levels of VDR and normal binding of VDR to vitamin D response elements. Vitamin D 67-76 vitamin D receptor Homo sapiens 60-63 15570014-1 2004 Vitamin D is a conditionally required nutrient traditionally thought to influence physiology as the metabolite 1,25-dihydroxyvitamin D [1,25(OH)(2) D] by binding to the vitamin D receptor (VDR) and stimulating the transcription of genes through direct VDR-DNA interactions. Vitamin D 0-9 vitamin D receptor Homo sapiens 252-255 15448105-2 2004 Vitamin D acts via its receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 33-36 15474498-6 2004 In a mammalian two-hybrid system, S182D bound less avidly than wild-type or S182A hVDR to the retinoid X receptor (RXR) heterodimeric partner that co-mediates vitamin D responsive element recognition and transactivation. Vitamin D 159-168 vitamin D receptor Homo sapiens 82-86 15876428-0 2004 Lipopolysaccharide negatively modulates vitamin D action by down-regulating expression of vitamin D-induced VDR in human monocytic THP-1 cells. Vitamin D 40-49 vitamin D receptor Homo sapiens 108-111 15876428-0 2004 Lipopolysaccharide negatively modulates vitamin D action by down-regulating expression of vitamin D-induced VDR in human monocytic THP-1 cells. Vitamin D 90-99 vitamin D receptor Homo sapiens 108-111 15876428-2 2004 Vitamin D receptor (VDR) belongs to a nuclear receptor super-family that mediates the genomic actions of vitamin D3 and regulates gene expression by binding with vitamin D response elements in the promoter region of the cognate gene. Vitamin D 105-114 vitamin D receptor Homo sapiens 0-18 15876428-2 2004 Vitamin D receptor (VDR) belongs to a nuclear receptor super-family that mediates the genomic actions of vitamin D3 and regulates gene expression by binding with vitamin D response elements in the promoter region of the cognate gene. Vitamin D 105-114 vitamin D receptor Homo sapiens 20-23 15308610-1 2004 Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disease caused by mutations in the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 108-126 15308610-1 2004 Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disease caused by mutations in the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 41-44 15297458-1 2004 An earlier report in the literature indicated the vitamin D response element (VDRE) in the human parathyroid hormone (hPTH) promoter could be specifically bound by an unidentified transcription factor in addition to the vitamin D receptor (VDR) complex. Vitamin D 50-59 vitamin D receptor Homo sapiens 220-238 15297458-1 2004 An earlier report in the literature indicated the vitamin D response element (VDRE) in the human parathyroid hormone (hPTH) promoter could be specifically bound by an unidentified transcription factor in addition to the vitamin D receptor (VDR) complex. Vitamin D 50-59 vitamin D receptor Homo sapiens 78-81 15297458-8 2004 Furthermore, findings suggest that the repressive effects of vitamin D on hPTH gene transcription may involve displacement of NF-Y binding to the proximal site by the VDR heterodimer, which subsequently attenuates synergistic transactivation. Vitamin D 61-70 vitamin D receptor Homo sapiens 167-170 15252846-12 2004 The risk associated with VDR genotype seems to depend upon the level of dietary calcium and vitamin D and tumor site. Vitamin D 92-101 vitamin D receptor Homo sapiens 25-28 15295697-10 2004 These findings demonstrate the potential clinical relevance of immunomodulatory functions of vitamin D metabolites acting via the VDR in the host response against pulmonary TB. Vitamin D 93-102 vitamin D receptor Homo sapiens 130-133 15252846-1 2004 The vitamin D receptor (VDR) may importantly modulate risk of colorectal cancer either independently or in conjunction with calcium and vitamin D intake. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 15109656-1 2004 Novel vitamin D(3) analogs having a lactam structure in their side chains, 1 alpha,25-dihydroxyvitamin D(3)-26,23-lactams (DLAMs), were designed based on the principle of regulation of the folding of helix-12 in the vitamin D nuclear receptor (VDR). Vitamin D 6-15 vitamin D receptor Homo sapiens 216-242 15326291-4 2004 Data obtained from docking five different vitamin D sterols in the genomic and alternative pockets were used to generate a receptor conformational ensemble model, providing an explanation for how VDR and possibly the estrogen receptor can have genomic and NG functionality. Vitamin D 42-51 vitamin D receptor Homo sapiens 196-199 15218361-7 2004 Electrophoretic mobility shift assays using a putative vitamin D response element within this region of the EGFR promoter demonstrated specific VDR binding. Vitamin D 55-64 vitamin D receptor Homo sapiens 144-147 15190891-1 2004 INTRODUCTION: Hereditary vitamin D--resistant rickets (HVDRR) is a genetic disorder caused by mutations in the vitamin D receptor (VDR). Vitamin D 25-34 vitamin D receptor Homo sapiens 111-129 15190891-1 2004 INTRODUCTION: Hereditary vitamin D--resistant rickets (HVDRR) is a genetic disorder caused by mutations in the vitamin D receptor (VDR). Vitamin D 25-34 vitamin D receptor Homo sapiens 56-59 15109656-1 2004 Novel vitamin D(3) analogs having a lactam structure in their side chains, 1 alpha,25-dihydroxyvitamin D(3)-26,23-lactams (DLAMs), were designed based on the principle of regulation of the folding of helix-12 in the vitamin D nuclear receptor (VDR). Vitamin D 6-15 vitamin D receptor Homo sapiens 244-247 15039597-8 2004 An association between the expression level of the vitamin D receptor (VDR) and EB1089 sensitivity was observed, suggesting that VDR is a possible predictive marker for response to vitamin D treatment. Vitamin D 51-60 vitamin D receptor Homo sapiens 71-74 15039597-8 2004 An association between the expression level of the vitamin D receptor (VDR) and EB1089 sensitivity was observed, suggesting that VDR is a possible predictive marker for response to vitamin D treatment. Vitamin D 51-60 vitamin D receptor Homo sapiens 129-132 15104566-1 2004 OBJECTIVE: Vitamin D modulates the immune system by suppressing the proliferation of activated T cells, with its actions being directed through the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 148-166 15104566-1 2004 OBJECTIVE: Vitamin D modulates the immune system by suppressing the proliferation of activated T cells, with its actions being directed through the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 168-171 15225750-1 2004 To clarify the structure-function relationship (SFR) of vitamin D analogs in terms of their interaction with the vitamin D receptor (VDR), we have proposed a new approach, two-dimensional alanine scanning mutational analysis (2D-ASMA). Vitamin D 56-65 vitamin D receptor Homo sapiens 113-131 15225755-1 2004 All Vitamin D analogs possessing the A ring modified at C-2 and showing calcemic activities nest themselves in the VDR binding pocket, oriented towards Tyr 143. Vitamin D 4-13 vitamin D receptor Homo sapiens 115-118 15225766-4 2004 Using immunohistochemistry, we have now detected nuclear Vitamin D receptor (VDR) immunoreactivity in primary cutaneous malignant melanoma (MM), indicating that Vitamin D metabolites may be of importance for the growth regulation in these tumors. Vitamin D 57-66 vitamin D receptor Homo sapiens 77-80 15225750-1 2004 To clarify the structure-function relationship (SFR) of vitamin D analogs in terms of their interaction with the vitamin D receptor (VDR), we have proposed a new approach, two-dimensional alanine scanning mutational analysis (2D-ASMA). Vitamin D 56-65 vitamin D receptor Homo sapiens 133-136 15225769-4 2004 Chromatin immunoprecipitation studies show that NCoA62/SKIP is recruited in a 1,25-(OH)(2)D(3)-dependent manner to native Vitamin D responsive gene promoters and it enters these promoter complexes after VDR and SRC entry. Vitamin D 122-131 vitamin D receptor Homo sapiens 203-206 15225804-4 2004 Additionally, modulation of cell proliferation by calpain inhibitors, as well as regulation of mRNA expression of VDR, 1alpha-OHase, and 24-OHase genes by Vitamin D analogs were assessed in melanoma cell lines in vitro using a WST-1 based colorimetric assay and real-time PCR, respectively. Vitamin D 155-164 vitamin D receptor Homo sapiens 114-117 15225769-9 2004 They further solidify an important role for VDR/NR-interactors downstream of the transcription process in determining the overall response of Vitamin D and steroid hormone regulated genes. Vitamin D 142-151 vitamin D receptor Homo sapiens 44-47 15255308-4 2004 Additional susceptibility is conferred by genomic variants of the vitamin D system (vitamin D receptor and CYP1 alpha hydroxylase). Vitamin D 66-75 vitamin D receptor Homo sapiens 84-102 15225833-7 2004 Given the pivotal effects of the Vitamin D receptor on gene transcription, it is likely that the anti-carcinogenic effects of Vitamin D that have previously been described are related to the activity and expression of the Vitamin D receptor and should be investigated further. Vitamin D 33-42 vitamin D receptor Homo sapiens 222-240 15066918-1 2004 OBJECTIVE: Vitamin D is a potential agent for the prevention of colorectal cancer possibly through mechanisms mediated by the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 126-144 15055995-4 2004 Here, we report the crystal structures of VDR ligand binding domain bound to two vitamin D agonists of therapeutical interest, calcipotriol and seocalcitol, which are characterized by their side chain modifications. Vitamin D 81-90 vitamin D receptor Homo sapiens 42-45 15066918-1 2004 OBJECTIVE: Vitamin D is a potential agent for the prevention of colorectal cancer possibly through mechanisms mediated by the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 146-149 15083599-2 2004 The binding of 1 alpha,25-dihydroxyvitamin D3 to the vitamin D receptor (VDR), a nuclear receptor, activates VDR to interact with retinoid X receptor (RXR) and form the VDR/RXR/co-factor complex, which binds to vitamin D response elements in the promoter region of target genes to regulate gene transcription. Vitamin D 35-44 vitamin D receptor Homo sapiens 53-71 15083599-2 2004 The binding of 1 alpha,25-dihydroxyvitamin D3 to the vitamin D receptor (VDR), a nuclear receptor, activates VDR to interact with retinoid X receptor (RXR) and form the VDR/RXR/co-factor complex, which binds to vitamin D response elements in the promoter region of target genes to regulate gene transcription. Vitamin D 35-44 vitamin D receptor Homo sapiens 73-76 15083599-2 2004 The binding of 1 alpha,25-dihydroxyvitamin D3 to the vitamin D receptor (VDR), a nuclear receptor, activates VDR to interact with retinoid X receptor (RXR) and form the VDR/RXR/co-factor complex, which binds to vitamin D response elements in the promoter region of target genes to regulate gene transcription. Vitamin D 35-44 vitamin D receptor Homo sapiens 109-112 15083599-2 2004 The binding of 1 alpha,25-dihydroxyvitamin D3 to the vitamin D receptor (VDR), a nuclear receptor, activates VDR to interact with retinoid X receptor (RXR) and form the VDR/RXR/co-factor complex, which binds to vitamin D response elements in the promoter region of target genes to regulate gene transcription. Vitamin D 35-44 vitamin D receptor Homo sapiens 109-112 14525957-4 2004 In both vitamin D response element activation and mammalian two-hybrid assays, we found that VDR-S278V is activated by 1alpha,25(OH)2D3 but not by LCA, whereas VDR-S237M can respond to LCA but not to 1alpha,25(OH)2D3. Vitamin D 8-17 vitamin D receptor Homo sapiens 93-96 15147236-5 2004 VDR upon binding 1a,25-dihydroxyvitamin D3 regulates specific gene transcription predominantly by binding as a heterodimer with the retinoid X receptor (RXR) to DNA enhancer sequence, termed the vitamin D-responsive element (VDRE) that is present within the promoter region of vitamin D-controlled genes. Vitamin D 32-41 vitamin D receptor Homo sapiens 0-3 15147236-5 2004 VDR upon binding 1a,25-dihydroxyvitamin D3 regulates specific gene transcription predominantly by binding as a heterodimer with the retinoid X receptor (RXR) to DNA enhancer sequence, termed the vitamin D-responsive element (VDRE) that is present within the promoter region of vitamin D-controlled genes. Vitamin D 195-204 vitamin D receptor Homo sapiens 0-3 14507914-6 2003 The inhibition was abolished by mutagenesis of the putative vitamin D response elements and was enhanced by overexpression of VDR. Vitamin D 60-69 vitamin D receptor Homo sapiens 126-129 14730505-6 2004 Furthermore, VDR function, as a transcriptional regulator of vitamin D responsive genes, is impaired by several factors including hypocalcemia, hyperphosphatemia, accumulation of uremic toxins, and reduction in cellular levels of the VDR partner, retinoid X receptor. Vitamin D 61-70 vitamin D receptor Homo sapiens 13-16 14730505-6 2004 Furthermore, VDR function, as a transcriptional regulator of vitamin D responsive genes, is impaired by several factors including hypocalcemia, hyperphosphatemia, accumulation of uremic toxins, and reduction in cellular levels of the VDR partner, retinoid X receptor. Vitamin D 61-70 vitamin D receptor Homo sapiens 234-237 14685312-2 2003 Introducing functional groups into the 2[small alpha]-position of the vitamin D-26,23-lactones resulted in remarkable enhancement of their antagonistic activity on vitamin D receptor (VDR). Vitamin D 70-79 vitamin D receptor Homo sapiens 164-182 14685312-2 2003 Introducing functional groups into the 2[small alpha]-position of the vitamin D-26,23-lactones resulted in remarkable enhancement of their antagonistic activity on vitamin D receptor (VDR). Vitamin D 70-79 vitamin D receptor Homo sapiens 184-187 14676077-3 2003 Atrichia with papules also occurs in the clinical setting of vitamin D-dependent rickets type IIA (VDDR IIA; OMIM 277440), resulting from mutations in the vitamin D receptor gene on chromosome 12q12-q14. Vitamin D 61-70 vitamin D receptor Homo sapiens 155-173 14572242-5 2003 The novel analogues efficiently bind VDR in vivo to induce transcription from a consensus vitamin D responsive element (VDRE). Vitamin D 90-99 vitamin D receptor Homo sapiens 37-40 14698202-1 2003 A modified yeast one-hybrid screen was used to isolate proteins capable of interacting with the Vitamin D receptor (VDR) heterodimer complex while driving expression from a repressor Vitamin D response element (VDRE). Vitamin D 96-105 vitamin D receptor Homo sapiens 116-119 14506229-4 2003 A DR3-type vitamin D response element was identified in the fourth exon of GADD45 that forms a complex with the vitamin D receptor.retinoid X receptor heterodimer in electrophoresis mobility shift assays and mediates the dose-dependent induction of luciferase activity by 1,25-dihydroxyvitamin D3 in reporter assays. Vitamin D 11-20 vitamin D receptor Homo sapiens 112-130 14572874-3 2003 This may be interpreted to indicate a close relationship between VDR gene polymorphism and the immunological action, because vitamin D activates monocytes, stimulates cell-mediated immunity, and suppresses lymphocyte proliferation. Vitamin D 125-134 vitamin D receptor Homo sapiens 65-68 14597850-1 2003 BACKGROUND: There are no studies that relate BsmI polymorphism of the vitamin D receptor (VDR) gene and with vitamin D to blood pressure (BP). Vitamin D 70-79 vitamin D receptor Homo sapiens 90-93 12843209-0 2003 Corepressor excess shifts the two-side chain vitamin D analog Gemini from an agonist to an inverse agonist of the vitamin D receptor. Vitamin D 45-54 vitamin D receptor Homo sapiens 114-132 14594170-2 2003 in infants with nutritional vitamin D deficiency rickets (VDR). Vitamin D 28-37 vitamin D receptor Homo sapiens 58-61 14594170-3 2003 Our purpose was to determine the most effective dosage of vitamin D with least side effects for treating VDR. Vitamin D 58-67 vitamin D receptor Homo sapiens 105-108 14594170-10 2003 In conclusion, our findings showed that 150,000 IU or 300,000 IU of vitamin D was adequate in the treatment of VDR, but 600,000 IU of vitamin D may carry the risk of hypercalcemia. Vitamin D 68-77 vitamin D receptor Homo sapiens 111-114 14631893-4 2003 The effects of vitamin D are mediated by the nuclear vitamin D receptor, which heterodimerizes with the retinoid X receptor and changes gene transcription. Vitamin D 15-24 vitamin D receptor Homo sapiens 53-71 14708943-5 2003 Moreover, 1,25-(OH)2D3 was validated as a regulator of the endogenous PDGF-A gene by the vitamin D-stimulated upregulation of PDGF-A mRNA levels in a VDR-expressing clone of JEG-3 cells. Vitamin D 89-98 vitamin D receptor Homo sapiens 150-153 12716975-3 2003 Here we present evidence for a similar mechanism in humans via a patient with resistance to the active form of vitamin D [1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3))] who presented with normal vitamin D receptor (VDR) expression. Vitamin D 111-120 vitamin D receptor Homo sapiens 194-212 12898515-1 2003 Abstract vitamin D receptor (VDR) and retinoid X receptor (RXR) heterodimerize to mediate the genomic actions of 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3), calcitriol), the biologically active form of vitamin D(3). Vitamin D 9-18 vitamin D receptor Homo sapiens 29-32 12858342-5 2003 Both electrophoresis mobility shift assay (EMSA) and transfection studies demonstrated that 1alpha,25(OH)(2)D(3) activated human RANKL promoter through vitamin D responsive elements (VDRE) located at -1584/-1570 by binding VDR and RXRalpha heterodimers in a ligand-dependent manner. Vitamin D 152-161 vitamin D receptor Homo sapiens 183-186 12753256-0 2003 Vitamin D receptor: mechanisms for vitamin D resistance in renal failure. Vitamin D 35-44 vitamin D receptor Homo sapiens 0-18 12753256-5 2003 Early interventions with 1,25(OH)2D3 could delay the onset of vitamin D resistance by preventing both 1,25(OH)2D3 deficiency and its critical consequence, reduction in VDR content. Vitamin D 62-71 vitamin D receptor Homo sapiens 168-171 12771291-4 2003 In the myelomonocytic cell line, active vitamin D(3) is known to activate the transcription of both p21 and p27, cyclin-dependent kinase inhibitors (CDKIs), regulating the transition from the G(1) to the S phase of the cell cycle, in a VDR-dependent manner. Vitamin D 40-49 vitamin D receptor Homo sapiens 236-239 12716897-4 2003 We show that Ski can negatively regulate vitamin D-mediated transcription by directly interacting with the vitamin D receptor. Vitamin D 41-50 vitamin D receptor Homo sapiens 107-125 12843155-2 2003 Vitamin D compounds are known to suppress T-cell activation by binding to the vitamin D receptor (VDR); and thus, VDR gene polymorphisms may be related to T-cell-mediated autoimmune diseases. Vitamin D 0-9 vitamin D receptor Homo sapiens 78-96 12843155-2 2003 Vitamin D compounds are known to suppress T-cell activation by binding to the vitamin D receptor (VDR); and thus, VDR gene polymorphisms may be related to T-cell-mediated autoimmune diseases. Vitamin D 0-9 vitamin D receptor Homo sapiens 98-101 12843155-2 2003 Vitamin D compounds are known to suppress T-cell activation by binding to the vitamin D receptor (VDR); and thus, VDR gene polymorphisms may be related to T-cell-mediated autoimmune diseases. Vitamin D 0-9 vitamin D receptor Homo sapiens 114-117 12840219-1 2003 The vitamin D-3 receptor (VDR) is a nuclear receptor that modulates gene expression when complexed with its ligand 1-alpha,25-dihydroxycholecalciferol [1,25(OH)(2)-D(3)], which is the biologically active form of vitamin D-3. Vitamin D 4-13 vitamin D receptor Homo sapiens 26-29 12840219-2 2003 The cellular effects of VDR signaling include growth arrest, differentiation and/or induction of apoptosis, which indicate that the vitamin D pathway participates in negative-growth regulation. Vitamin D 132-141 vitamin D receptor Homo sapiens 24-27 12840219-5 2003 Furthermore, preclinical studies show that vitamin D compounds can reduce breast cancer development in animals, and human data indicate that both vitamin D status and genetic variations in the VDR may affect breast cancer risk. Vitamin D 43-52 vitamin D receptor Homo sapiens 193-196 14746673-14 2003 CONCLUSION: There is an association between VDR gene start codon polymorphism and vitamin D deficiency rickets. Vitamin D 82-91 vitamin D receptor Homo sapiens 44-47 14746673-15 2003 This study suggested the possibility that VDR gene polymorphism might be important in determining an individual"s susceptibility to development of vitamin D deficiency rickets. Vitamin D 147-156 vitamin D receptor Homo sapiens 42-45 12837248-6 2003 Furthermore, overexpression of WSTF could restore the impaired recruitment of VDR to vitamin D regulated promoters in fibroblasts from Williams syndrome patients. Vitamin D 85-94 vitamin D receptor Homo sapiens 78-81 12761332-0 2003 Structural evaluation of the agonistic action of a vitamin D analog with two side chains binding to the nuclear vitamin D receptor. Vitamin D 51-60 vitamin D receptor Homo sapiens 112-130 12716975-3 2003 Here we present evidence for a similar mechanism in humans via a patient with resistance to the active form of vitamin D [1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3))] who presented with normal vitamin D receptor (VDR) expression. Vitamin D 111-120 vitamin D receptor Homo sapiens 214-217 12570725-6 2003 By far the biggest class of vitamin D analogs are the VDR agonists which directly mimic 1alpha,25(OH)(2)D(3) and trigger protein conformational changes in the receptor which lead to changes in the transcriptional machinery at vitamin D-responsive genes. Vitamin D 28-37 vitamin D receptor Homo sapiens 54-57 12697832-3 2003 In osteoblastic cells, transcription of the bone-specific osteocalcin (OC) gene is principally regulated by the Runx2/Cbfa1 transcription factor and is stimulated in response to vitamin D(3) via the vitamin D(3) receptor complex. Vitamin D 178-187 vitamin D receptor Homo sapiens 199-220 12612432-0 2003 2 alpha-(3-hydroxypropyl)- and 2 alpha-(3-hydroxypropoxy)-1 alpha,25-dihydroxyvitamin D3 accessible to vitamin D receptor mutant related to hereditary vitamin D-resistant rickets. Vitamin D 78-87 vitamin D receptor Homo sapiens 103-121 12612432-1 2003 Hereditary vitamin D-resistant rickets (HVDRR) is a genetic disorder caused by mutations in the vitamin D receptor, which lead to resistance to 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)]. Vitamin D 11-20 vitamin D receptor Homo sapiens 96-114 12570725-6 2003 By far the biggest class of vitamin D analogs are the VDR agonists which directly mimic 1alpha,25(OH)(2)D(3) and trigger protein conformational changes in the receptor which lead to changes in the transcriptional machinery at vitamin D-responsive genes. Vitamin D 226-235 vitamin D receptor Homo sapiens 54-57 12520535-1 2003 Rickets and hyperparathyroidism caused by a defective Vitamin D receptor (VDR) can be prevented in humans and animals by high calcium intake, suggesting that intestinal calcium absorption is critical for 1,25(OH)(2) vitamin D [1,25-(OH)(2)D(3)] action on calcium homeostasis. Vitamin D 216-225 vitamin D receptor Homo sapiens 54-72 12520535-1 2003 Rickets and hyperparathyroidism caused by a defective Vitamin D receptor (VDR) can be prevented in humans and animals by high calcium intake, suggesting that intestinal calcium absorption is critical for 1,25(OH)(2) vitamin D [1,25-(OH)(2)D(3)] action on calcium homeostasis. Vitamin D 216-225 vitamin D receptor Homo sapiens 74-77 14977005-0 2003 [Molecular model of A-ring modified vitamin D bound to VDR]. Vitamin D 36-45 vitamin D receptor Homo sapiens 55-58 12710998-2 2003 Elucidation of Vitamin D(3) receptor (VDR) regulation may reveal strategies to sensitize cancer cells to the effects of 1,25-dihydroxyvitamin D(3) and Vitamin D(3) analogs. Vitamin D 15-24 vitamin D receptor Homo sapiens 38-41 12710998-9 2003 Because resveratrol could up-regulate VDR without increasing breast cancer cell growth, we hypothesized that resveratrol mediated increase in VDR expression would sensitize breast cancer cells to the effects of 1,25-dihydroxyvitamin D(3) and Vitamin D(3) analogs. Vitamin D 242-251 vitamin D receptor Homo sapiens 142-145 12710998-10 2003 In support of this hypothesis, both T47D and MCF-7 cells pre-treated with resveratrol exhibited increased VDR mediated transactivation of a Vitamin D(3) responsive promoter compared to cells pre-treated with vehicle. Vitamin D 140-149 vitamin D receptor Homo sapiens 106-109 12710998-12 2003 These data support the concept that dietary factors, such as phytoestrogens, may impact on breast cancer cell sensitivity to Vitamin D(3) analogs through regulation of the VDR promoter. Vitamin D 125-134 vitamin D receptor Homo sapiens 172-175 18650961-4 2003 Vitamin D exerts its genomic effects through a nuclear gene transcription factor, the vitamin D receptor (VDR), while metabolism of vitamin D both to its biologically active form, as well as to its excretory product, plays a major role in determining biological activity at the tissue level. Vitamin D 0-9 vitamin D receptor Homo sapiens 86-104 18650961-4 2003 Vitamin D exerts its genomic effects through a nuclear gene transcription factor, the vitamin D receptor (VDR), while metabolism of vitamin D both to its biologically active form, as well as to its excretory product, plays a major role in determining biological activity at the tissue level. Vitamin D 0-9 vitamin D receptor Homo sapiens 106-109 18650961-4 2003 Vitamin D exerts its genomic effects through a nuclear gene transcription factor, the vitamin D receptor (VDR), while metabolism of vitamin D both to its biologically active form, as well as to its excretory product, plays a major role in determining biological activity at the tissue level. Vitamin D 86-95 vitamin D receptor Homo sapiens 106-109 14683515-0 2003 Vitamin D analogs as modulators of vitamin D receptor action. Vitamin D 0-9 vitamin D receptor Homo sapiens 35-53 12424754-0 2003 Structure-function relationships of vitamin D including ligand recognition by the vitamin D receptor. Vitamin D 36-45 vitamin D receptor Homo sapiens 82-100 12498876-1 2002 Vitamin D-resistant rickets is a genetic disease that causes severe bone underdevelopment due to mutations in the vitamin D receptor. Vitamin D 0-9 vitamin D receptor Homo sapiens 114-132 12424754-1 2003 First, the general structure and function of nuclear receptors (NRs) are described briefly to help our understanding of the mechanism of action of vitamin D mediated by the vitamin D receptor (VDR), a member of the NRs. Vitamin D 147-156 vitamin D receptor Homo sapiens 173-191 12424754-1 2003 First, the general structure and function of nuclear receptors (NRs) are described briefly to help our understanding of the mechanism of action of vitamin D mediated by the vitamin D receptor (VDR), a member of the NRs. Vitamin D 147-156 vitamin D receptor Homo sapiens 193-196 12424754-2 2003 Then we discuss the structure-function relationship (SFR) of vitamin D on the basis of ligand structures and the interaction of the ligand with the VDR. Vitamin D 61-70 vitamin D receptor Homo sapiens 148-151 12424754-5 2003 The SFR of ligand/VDR interaction is discussed on the basis of the crystal structure of VDR-LBD(delta 165-215), docking of various vitamin D ligands into the ligand binding pocket (LBP) of the VDR, and functional analysis of amino acids lining the LBP. Vitamin D 131-140 vitamin D receptor Homo sapiens 18-21 12899528-2 2003 We have now characterized the key components of the vitamin D system (VDR, 1alpha-OHase, 24-OHase and 25-OHase) in cutaneous basal cell carcinomas (BCC) and squamous cell carcinomas (SCC), using immunohistochemical and quantitative real-time PCR techniques. Vitamin D 52-61 vitamin D receptor Homo sapiens 70-73 12899530-2 2003 We focused on the structure-activity relationships of the A-ring moiety of the vitamin D molecule and found several strong agonists of the vitamin D receptor, using a design of introducing a functional group into the C2 position. Vitamin D 79-88 vitamin D receptor Homo sapiens 139-157 12617040-3 2003 On the other hand, vitamin D compounds are known to have multiple actions in many organs (promotion of calcium absorption from the small intestine, induction of differentiation of leukemia cells, differentiation and proliferation of the chondrocyte, muscle cells and epidermal cells, immunosuppressive activities) and their activities on parathyroid glands seem to be mediated by the vitamin D receptor (genomic action). Vitamin D 19-28 vitamin D receptor Homo sapiens 384-402 12899516-9 2003 1,25(OH)2D regulates gene expression by activating the vitamin D receptor (VDR), a transcription factor, which, in combination with the retinoid X receptor (RXR) or retinoid A receptor (RAR), binds to its vitamin D response elements (VDRE) in the promoters of genes whose expression it regulates. Vitamin D 55-64 vitamin D receptor Homo sapiens 75-78 12460926-0 2002 AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor. Vitamin D 44-53 vitamin D receptor Homo sapiens 101-122 12444900-2 2002 Active vitamin D, 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)), with the vitamin D receptor (VDR) is involved in regulation of the calcium homeostasis together with PTH. Vitamin D 7-16 vitamin D receptor Homo sapiens 74-92 12431109-2 2002 Mutations to the vitamin D receptor (VDR), a member of the nuclear and steroid hormone receptor family, have been linked to human vitamin D-resistant rickets (hVDRR) and result in high serum 1,25(OH)(2)D(3) concentrations and severe bone underdevelopment. Vitamin D 17-26 vitamin D receptor Homo sapiens 37-40 12444900-2 2002 Active vitamin D, 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)), with the vitamin D receptor (VDR) is involved in regulation of the calcium homeostasis together with PTH. Vitamin D 7-16 vitamin D receptor Homo sapiens 94-97 12413773-2 2002 We also studied the association between VDR gene polymorphisms and the response to vitamin D (VD) topical treatment in psoriatic patients. Vitamin D 83-92 vitamin D receptor Homo sapiens 40-43 12445200-8 2002 The vitamin D response element from the involucrin gene bound the vitamin D receptor and the retinoid X receptor, but not the retinoic acid receptor, in a specific manner. Vitamin D 4-13 vitamin D receptor Homo sapiens 66-84 12237325-3 2002 In this study, we investigated structurally and functionally important amino acid interactions within the ligand binding pocket of the full-length VDR in the presence of several synthetic vitamin D(3) analogs. Vitamin D 188-197 vitamin D receptor Homo sapiens 147-150 12403843-1 2002 Hereditary vitamin D-resistant rickets (HVDRR) is a genetic disorder most often caused by mutations in the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 107-125 12403843-1 2002 Hereditary vitamin D-resistant rickets (HVDRR) is a genetic disorder most often caused by mutations in the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 41-44 12324918-2 2002 We hypothesized that the vitamin D receptor (VDR) genotype, which may differentiate response to endogenous or exogenous active vitamin D, has a role in the management of anemia in hemodialysis (HD) patients. Vitamin D 25-34 vitamin D receptor Homo sapiens 45-48 11983707-2 2002 Here we report that stress-activated protein kinases p38 and JNK trans-activate nuclear steroid vitamin D receptor (VDR) gene and increase vitamin D(3)-dependent growth inhibition in human breast cancer cells. Vitamin D 96-105 vitamin D receptor Homo sapiens 116-119 12211444-6 2002 In conclusion, this case report of a new family with hereditary vitamin D-resistant rickets (HVDRR) emphasizes the crucial role of the VDR tryptophan for ligand binding and for transactivation of 1,25(OH)2D3 target genes. Vitamin D 64-73 vitamin D receptor Homo sapiens 94-97 11983707-7 2002 These results establish a signaling connection between the stress MAPK pathways and steroid hormone receptor VDR expression and thereby offer new insights into regulation of cell growth by the MAPK pathways through regulation of vitamin D(3)/VDR activity. Vitamin D 229-238 vitamin D receptor Homo sapiens 109-112 11983707-7 2002 These results establish a signaling connection between the stress MAPK pathways and steroid hormone receptor VDR expression and thereby offer new insights into regulation of cell growth by the MAPK pathways through regulation of vitamin D(3)/VDR activity. Vitamin D 229-238 vitamin D receptor Homo sapiens 242-245 12144199-3 2002 By contrast, a "vitamin D response element-binding protein" inhibits vitamin D receptor binding to the DNA and is responsible for vitamin D resistance in New World primates. Vitamin D 16-25 vitamin D receptor Homo sapiens 69-87 12174912-1 2002 BACKGROUND: The aim of this study was to analyze immunohistochemically the expression of VDR in normal and carcinomatous ovarian tissue to evaluate whether ovarian tissue may be a new potential target for biologically active vitamin D analogues. Vitamin D 225-234 vitamin D receptor Homo sapiens 89-92 12086963-0 2002 Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians. Vitamin D 68-77 vitamin D receptor Homo sapiens 0-18 12086963-0 2002 Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians. Vitamin D 68-77 vitamin D receptor Homo sapiens 20-23 12188026-1 2002 The active form of vitamin D, 1,25-Dihydroxyvitamin D3 [l,25(OH)2D3], is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the superfamily of nuclear receptors for steroid hormones, thyroid hormone, and retinoic acid. Vitamin D 19-28 vitamin D receptor Homo sapiens 113-131 12188026-1 2002 The active form of vitamin D, 1,25-Dihydroxyvitamin D3 [l,25(OH)2D3], is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the superfamily of nuclear receptors for steroid hormones, thyroid hormone, and retinoic acid. Vitamin D 19-28 vitamin D receptor Homo sapiens 133-136 11972530-3 2002 Because homozygous CC and BB VDR genotypes influence Vitamin D activity, they can be considered additional risk factors for bone disease in beta thalassaemia. Vitamin D 53-62 vitamin D receptor Homo sapiens 29-32 12016314-4 2002 Activation of VDR by LCA or vitamin D induced expression in vivo of CYP3A, a cytochrome P450 enzyme that detoxifies LCA in the liver and intestine. Vitamin D 28-37 vitamin D receptor Homo sapiens 14-17 12168894-7 2002 The strong VDR immunoreactivity that we observed in breast cancer specimens supports the body of evidence that breast cancer may be a target for therapeutically applied vitamin D analogues. Vitamin D 169-178 vitamin D receptor Homo sapiens 11-14 11743608-3 2002 VDR binds as a heterodimer with retinoid X receptor (R X R) to hexameric repeats, characterized as vitamin D-responsive elements present in the regulatory region of target genes such as osteocalcin, osteopontin, calbindin-D28K, calbindin-D9K, p21WAF1/CIP1, TGF-beta2 and vitamin D 24-hydroxylase. Vitamin D 99-108 vitamin D receptor Homo sapiens 0-3 11920955-1 2002 BACKGROUND: 1,25-dihydroxyvitamin D, the active form of vitamin D, exerts antiproliferative effect on prostatic cells, mediated through the vitamin D receptor. Vitamin D 26-35 vitamin D receptor Homo sapiens 140-158 11890700-1 2002 1,25-Dihydroxyvitamin D(3) [1,25(OH)(2) D(3)] exerts its biological effects by binding to the vitamin D receptor (VDR), which binds in turn to the vitamin D response elements located in the target gene"s promoter. Vitamin D 14-23 vitamin D receptor Homo sapiens 94-112 11890700-1 2002 1,25-Dihydroxyvitamin D(3) [1,25(OH)(2) D(3)] exerts its biological effects by binding to the vitamin D receptor (VDR), which binds in turn to the vitamin D response elements located in the target gene"s promoter. Vitamin D 14-23 vitamin D receptor Homo sapiens 114-117 11991436-4 2002 Non-genomic effects of vitamin D are rapid and mediated through a membrane-bound vitamin D receptor (VDR). Vitamin D 23-32 vitamin D receptor Homo sapiens 101-104 12009019-0 2002 Vitamin D analogue-specific recruitment of vitamin D receptor coactivators. Vitamin D 0-9 vitamin D receptor Homo sapiens 43-61 11916748-5 2002 From experimental studies it was found that vitamin D metabolites directly influence muscle cell maturation and functioning through a vitamin D receptor. Vitamin D 44-53 vitamin D receptor Homo sapiens 134-152 11963993-13 2002 This biological information in combination with the NMR properties indicates that 2a and 4a are promising probes for studying the VDR-bound A-ring conformation of vitamin D. Vitamin D 163-172 vitamin D receptor Homo sapiens 130-133 11909970-5 2002 This prevents VDR-retinoid X receptor (RXR) binding to the vitamin D-responsive element, thus diverting the VDR from its normal genomic target on the 24-hydroxylase promoter and antagonizing 1,25D-VDR transactivation of this gene. Vitamin D 59-68 vitamin D receptor Homo sapiens 14-17 11909970-5 2002 This prevents VDR-retinoid X receptor (RXR) binding to the vitamin D-responsive element, thus diverting the VDR from its normal genomic target on the 24-hydroxylase promoter and antagonizing 1,25D-VDR transactivation of this gene. Vitamin D 59-68 vitamin D receptor Homo sapiens 108-111 11991436-4 2002 Non-genomic effects of vitamin D are rapid and mediated through a membrane-bound vitamin D receptor (VDR). Vitamin D 23-32 vitamin D receptor Homo sapiens 81-99 11857931-3 2002 Hereditary 1,25-dihydroxyvitamin D resistant rickets (HVDRR) known as vitamin D dependent rickets type II is a rare autosomal recessive disease that arises as a result of mutations in the gene encoding the VDR. Vitamin D 25-34 vitamin D receptor Homo sapiens 55-58 12446995-1 2002 Vitamin-D-dependent rickets type 2 results from autosomal recessive mutations of the vitamin D receptor gene. Vitamin D 0-9 vitamin D receptor Homo sapiens 85-103 11815408-5 2002 We examined the association between fasting levels of 25-OH D(3), 1,25-(OH)(2) D(3), and BsmI polymorphism of the vitamin D receptor (VDR) gene with indices of colonic epithelial cell proliferation and differentiation in a chemoprevention study, after giving vitamin D or calcium and taking rectal biopsies that were incubated with bromodeoxyuridine. Vitamin D 114-123 vitamin D receptor Homo sapiens 134-137 12365798-7 2002 VDR and RXR-alpha are upregulated at the protein level in breast carcinomas as compared to normal breast tissue, indicating a possibly increased sensitivity to therapeutically applied vitamin D analogues. Vitamin D 184-193 vitamin D receptor Homo sapiens 0-3 12006701-5 2002 Two types of vitamin D-dependent hereditary rickets (VDDR) are known to be caused by mutations in the 1alpha(OH)ase and VDR genes. Vitamin D 13-22 vitamin D receptor Homo sapiens 120-123 11514567-1 2001 The vitamin D receptor (VDR) is a ligand-dependent transcriptional factor that binds to vitamin D-responsive elements as a heterodimer with retinoid X receptor (RXR) to regulate target gene transcription. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 11948698-2 2002 To address these issues, milligram quantities of baculovirus-expressed hVDR were purified to 97% homogeneity, and then tested for binding to the rat osteocalcin vitamin D responsive element (VDRE) via electrophoretic mobility shift and half-site competition assays in the presence or absence of a CV-1 nuclear extract containing retinoid X receptor (RXR). Vitamin D 161-170 vitamin D receptor Homo sapiens 71-75 12181642-2 2002 Antiproliferative effects of vitamin D require the expression of the nuclear vitamin D receptor (VDR). Vitamin D 29-38 vitamin D receptor Homo sapiens 77-95 12181642-2 2002 Antiproliferative effects of vitamin D require the expression of the nuclear vitamin D receptor (VDR). Vitamin D 29-38 vitamin D receptor Homo sapiens 97-100 11751444-4 2001 In addition, the interrelation among vitamin D, calcium, and FokI polymorphism of the VDR gene was investigated. Vitamin D 37-46 vitamin D receptor Homo sapiens 86-89 11751444-2 2001 The effects of vitamin D and calcium may be mediated by the vitamin D receptor (VDR), which is encoded by the VDR gene. Vitamin D 15-24 vitamin D receptor Homo sapiens 60-78 11751444-2 2001 The effects of vitamin D and calcium may be mediated by the vitamin D receptor (VDR), which is encoded by the VDR gene. Vitamin D 15-24 vitamin D receptor Homo sapiens 80-83 11751444-2 2001 The effects of vitamin D and calcium may be mediated by the vitamin D receptor (VDR), which is encoded by the VDR gene. Vitamin D 15-24 vitamin D receptor Homo sapiens 110-113 11689383-7 2001 The nuclear VDR has been isolated from a variety of target cells and tissues, suggesting that vitamin D compounds may have therapeutic potential throughout several body systems. Vitamin D 94-103 vitamin D receptor Homo sapiens 12-15 11687634-1 2001 Rickets and hyperparathyroidism caused by a defective vitamin D receptor (VDR) can be prevented in humans and animals by high calcium intake, suggesting that intestinal calcium absorption is critical for 1,25(OH)(2) vitamin D [1,25(OH)(2)D(3)] action on calcium homeostasis. Vitamin D 54-63 vitamin D receptor Homo sapiens 74-77 11369766-1 2001 Hereditary vitamin D-resistant rickets (HVDRR) is caused by heterogeneous inactivating mutations in the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 104-122 11518809-5 2001 Isoform-specific VDRB1 expression constructs produced lower ligand-dependent transactivation than VDRA when transiently transfected with a vitamin D-responsive promoter into cell lines with low endogenous VDR. Vitamin D 139-148 vitamin D receptor Homo sapiens 17-20 11369766-1 2001 Hereditary vitamin D-resistant rickets (HVDRR) is caused by heterogeneous inactivating mutations in the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 41-44 11369766-4 2001 The rationale for the use of vitamin D analogs is that they bind the VDR at different amino acid residues than 1,25D(3), and their ability to modulate VDR functions differs from that of the natural hormone. Vitamin D 29-38 vitamin D receptor Homo sapiens 69-72 11369766-4 2001 The rationale for the use of vitamin D analogs is that they bind the VDR at different amino acid residues than 1,25D(3), and their ability to modulate VDR functions differs from that of the natural hormone. Vitamin D 29-38 vitamin D receptor Homo sapiens 151-154 11369766-6 2001 Our results reveal that vitamin D analogs partially or completely restore the responsiveness of the mutated VDR. Vitamin D 24-33 vitamin D receptor Homo sapiens 108-111 11489753-0 2001 Vitamin D receptor polymorphism and the risk of colorectal adenomas: evidence of interaction with dietary vitamin D and calcium. Vitamin D 106-115 vitamin D receptor Homo sapiens 0-18 11489753-1 2001 Laboratory studies and epidemiological investigations suggest that vitamin D plays a role in the etiology of colorectal adenomas, possibly through a mechanism mediated by the vitamin D receptor (VDR). Vitamin D 67-76 vitamin D receptor Homo sapiens 175-193 11489753-1 2001 Laboratory studies and epidemiological investigations suggest that vitamin D plays a role in the etiology of colorectal adenomas, possibly through a mechanism mediated by the vitamin D receptor (VDR). Vitamin D 67-76 vitamin D receptor Homo sapiens 195-198 11278818-2 2001 Members of the Smad family of proteins function as effectors of TGF-beta signaling pathways whereas the vitamin D receptor (VDR) confers vitamin D signaling. Vitamin D 104-113 vitamin D receptor Homo sapiens 124-127 11461072-2 2001 The actions of vitamin D are mediated via the vitamin D receptor (VDR). Vitamin D 15-24 vitamin D receptor Homo sapiens 46-64 11461072-2 2001 The actions of vitamin D are mediated via the vitamin D receptor (VDR). Vitamin D 15-24 vitamin D receptor Homo sapiens 66-69 11461072-9 2001 Further investigations into the mechanisms of interactions of the VDR with other environmental and/or genetic influences to alter breast cancer risk may lead to a new understanding of the role of vitamin D in the control of cellular and developmental pathways. Vitamin D 196-205 vitamin D receptor Homo sapiens 66-69 11376448-4 2001 In humans, patients with hypocalcemic vitamin D-resistant rickets type II have high circulating vitamin D levels and vitamin D resistance due to expression of a dysfunctional vitamin D receptor (VDR). Vitamin D 38-47 vitamin D receptor Homo sapiens 175-193 11376448-4 2001 In humans, patients with hypocalcemic vitamin D-resistant rickets type II have high circulating vitamin D levels and vitamin D resistance due to expression of a dysfunctional vitamin D receptor (VDR). Vitamin D 38-47 vitamin D receptor Homo sapiens 195-198 11376448-4 2001 In humans, patients with hypocalcemic vitamin D-resistant rickets type II have high circulating vitamin D levels and vitamin D resistance due to expression of a dysfunctional vitamin D receptor (VDR). Vitamin D 96-105 vitamin D receptor Homo sapiens 175-193 11376448-4 2001 In humans, patients with hypocalcemic vitamin D-resistant rickets type II have high circulating vitamin D levels and vitamin D resistance due to expression of a dysfunctional vitamin D receptor (VDR). Vitamin D 96-105 vitamin D receptor Homo sapiens 175-193 11376448-9 2001 These results indicate that the mechanism of vitamin D resistance in NWPs is not due to a dysfunctional VDR, and is consistent with our hypothesis that vitamin D resistance in NWPs is mediated by overexpression of a VDR-independent vitamin D response element binding protein. Vitamin D 152-161 vitamin D receptor Homo sapiens 216-219 11376448-9 2001 These results indicate that the mechanism of vitamin D resistance in NWPs is not due to a dysfunctional VDR, and is consistent with our hypothesis that vitamin D resistance in NWPs is mediated by overexpression of a VDR-independent vitamin D response element binding protein. Vitamin D 152-161 vitamin D receptor Homo sapiens 216-219 11432806-2 2001 The functions of 1,25-dihydroxyvitamin D(3) are mediated through the vitamin D(3) receptor (VDR); therefore, an understanding of the regulation of VDR expression is important when considering the molecular mechanisms of differentiation induced by vitamin D(3) and its analogues. Vitamin D 31-40 vitamin D receptor Homo sapiens 69-90 11432806-2 2001 The functions of 1,25-dihydroxyvitamin D(3) are mediated through the vitamin D(3) receptor (VDR); therefore, an understanding of the regulation of VDR expression is important when considering the molecular mechanisms of differentiation induced by vitamin D(3) and its analogues. Vitamin D 31-40 vitamin D receptor Homo sapiens 92-95 11389055-1 2001 Operating through the vitamin D receptor (VDR), vitamin D inhibits prostate cancer growth and increases insulin-like growth factor binding protein (IGFBP) expression, suggesting that the vitamin D and insulin-like growth factor (IGF) regulatory systems may operate together to affect prostate cancer. Vitamin D 22-31 vitamin D receptor Homo sapiens 42-45 11389055-1 2001 Operating through the vitamin D receptor (VDR), vitamin D inhibits prostate cancer growth and increases insulin-like growth factor binding protein (IGFBP) expression, suggesting that the vitamin D and insulin-like growth factor (IGF) regulatory systems may operate together to affect prostate cancer. Vitamin D 48-57 vitamin D receptor Homo sapiens 22-40 11389055-1 2001 Operating through the vitamin D receptor (VDR), vitamin D inhibits prostate cancer growth and increases insulin-like growth factor binding protein (IGFBP) expression, suggesting that the vitamin D and insulin-like growth factor (IGF) regulatory systems may operate together to affect prostate cancer. Vitamin D 48-57 vitamin D receptor Homo sapiens 42-45 11386849-1 2001 Mutations in the vitamin D receptor (VDR) cause hereditary vitamin D-resistant rickets (HVDRR), an autosomal recessive disease resulting in target organ resistance to 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)]. Vitamin D 17-26 vitamin D receptor Homo sapiens 37-40 11278818-10 2001 Thus the molecular mechanism, whereby Smad3 and VDR mediate cross-talk between the TGF-beta and vitamin D signaling pathways, requires both a VDRE and a SBE located in close proximity to the target promoter. Vitamin D 96-105 vitamin D receptor Homo sapiens 48-51 15775532-2 2001 Most of such biological actions of vitamin D are now considered to be exerted through nuclear vitamin D receptor (VDR) -mediated control of target genes. Vitamin D 35-44 vitamin D receptor Homo sapiens 94-112 11344183-0 2001 The role of the vitamin D receptor in regulating vitamin D metabolism: a study of vitamin D-dependent rickets, type II. Vitamin D 49-58 vitamin D receptor Homo sapiens 16-34 11344183-1 2001 In vitro studies and animal experiments suggest that the production of 1,25-dihydroxyvitamin D [1,25-(OH)(2)D] and 24,25-(OH)(2)D is reciprocally controlled by 1,25-(OH)(2)D. To investigate the role of the vitamin D receptor (VDR) in controlling vitamin D metabolism in humans, we studied 10 patients with vitamin D-dependent rickets type II due to a defective VDR. Vitamin D 85-94 vitamin D receptor Homo sapiens 206-224 11344183-1 2001 In vitro studies and animal experiments suggest that the production of 1,25-dihydroxyvitamin D [1,25-(OH)(2)D] and 24,25-(OH)(2)D is reciprocally controlled by 1,25-(OH)(2)D. To investigate the role of the vitamin D receptor (VDR) in controlling vitamin D metabolism in humans, we studied 10 patients with vitamin D-dependent rickets type II due to a defective VDR. Vitamin D 85-94 vitamin D receptor Homo sapiens 226-229 11344183-1 2001 In vitro studies and animal experiments suggest that the production of 1,25-dihydroxyvitamin D [1,25-(OH)(2)D] and 24,25-(OH)(2)D is reciprocally controlled by 1,25-(OH)(2)D. To investigate the role of the vitamin D receptor (VDR) in controlling vitamin D metabolism in humans, we studied 10 patients with vitamin D-dependent rickets type II due to a defective VDR. Vitamin D 85-94 vitamin D receptor Homo sapiens 361-364 11344183-9 2001 Thus, 1,25-(OH)(2)D-liganded VDR is a major control mechanism for vitamin D metabolism, and PTH exerts an additive effect. Vitamin D 66-75 vitamin D receptor Homo sapiens 29-32 11281654-3 2001 The vitamin D receptor (VDR) is another member of this superfamily, and the vitamin D pathway is important for prevention and therapy of osteoporosis, renal failure, cancer, and psoriasis. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 15775532-2 2001 Most of such biological actions of vitamin D are now considered to be exerted through nuclear vitamin D receptor (VDR) -mediated control of target genes. Vitamin D 35-44 vitamin D receptor Homo sapiens 114-117 11179725-0 2001 Three-dimensional structure-function relationship of vitamin D and vitamin D receptor model. Vitamin D 53-62 vitamin D receptor Homo sapiens 67-85 11259341-8 2001 At the pharmacogenetic level, VDR alleles predict differences in gut calcium absorption and long-term bone density response to calcium intake and active vitamin D analog treatment. Vitamin D 153-162 vitamin D receptor Homo sapiens 30-33 11441291-6 2001 It has been shown that certain vitamin D analogs differ in their intracellular metabolism, nongenomic actions, pharmacokinetics, interaction with the vitamin D binding protein (DBP) or the vitamin D receptor (VDR). Vitamin D 31-40 vitamin D receptor Homo sapiens 189-207 11441291-6 2001 It has been shown that certain vitamin D analogs differ in their intracellular metabolism, nongenomic actions, pharmacokinetics, interaction with the vitamin D binding protein (DBP) or the vitamin D receptor (VDR). Vitamin D 31-40 vitamin D receptor Homo sapiens 209-212 11441291-7 2001 Several of these new concepts are based on recent laboratory results demonstrating that VDR requires heterodimerisation with additional nuclear cofactors such as the retinoid-X receptor (RXR) for sufficient DNA-binding or are based on new findings in the metabolism of vitamin D. Vitamin D 269-278 vitamin D receptor Homo sapiens 88-91 11179724-0 2001 Vitamin D receptor and nuclear receptor coactivators: crucial interactions in vitamin D-mediated transcription. Vitamin D 78-87 vitamin D receptor Homo sapiens 0-18 11179728-0 2001 Central role of VDR conformations for understanding selective actions of vitamin D(3) analogues. Vitamin D 73-82 vitamin D receptor Homo sapiens 16-19 11251690-8 2001 The mechanisms by which the VDR polymorphism is associated with RA is unknown, but they could be related to the immunoregulatory properties of vitamin D. Vitamin D 143-152 vitamin D receptor Homo sapiens 28-31 11145567-1 2001 The vitamin D analog, (23S)-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactone (TEI-9647), is an antagonist of the 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] nuclear receptor (VDR)-mediated differentiation of human leukemia (HL-60) cells. Vitamin D 4-13 vitamin D receptor Homo sapiens 189-192 11500934-2 2001 At the cellular level, the principal action of vitamin D is mediated though vitamin D receptors (VDR). Vitamin D 47-56 vitamin D receptor Homo sapiens 76-95 11500934-2 2001 At the cellular level, the principal action of vitamin D is mediated though vitamin D receptors (VDR). Vitamin D 47-56 vitamin D receptor Homo sapiens 97-100 11498733-8 2001 Among the Japanese, sensitivity to vitamin D has been reported to vary between the alleles of the VDR; i.e., bone mineral density (BMD) in patients without the B allele is increased by vitamin D treatment, whereas patients with the B allele do not show such an increase in BMD. Vitamin D 35-44 vitamin D receptor Homo sapiens 98-101 11121228-4 2001 This phosphorylation event results in the inhibition of vitamin D signaling via VDR/hRXRalpha heterodimers. Vitamin D 56-65 vitamin D receptor Homo sapiens 80-83 11498733-8 2001 Among the Japanese, sensitivity to vitamin D has been reported to vary between the alleles of the VDR; i.e., bone mineral density (BMD) in patients without the B allele is increased by vitamin D treatment, whereas patients with the B allele do not show such an increase in BMD. Vitamin D 185-194 vitamin D receptor Homo sapiens 98-101 11500919-0 2001 MCF-7/VD(R): a new vitamin D resistant cell line. Vitamin D 19-28 vitamin D receptor Homo sapiens 0-11 11500919-9 2001 The MCF-7/VD(R) cell line shows characteristics different from those of previously described vitamin D resistant breast cancer cell lines but also some similarities. Vitamin D 93-102 vitamin D receptor Homo sapiens 4-15 10967105-4 2000 BAG1L, but not shorter non-nuclear isoforms of this protein (BAG1; BAG1M/Rap46), markedly enhanced, in a ligand-dependent manner, the ability of VDR to trans-activate reporter gene plasmids containing a vitamin D response element in transient transfection assays. Vitamin D 203-212 vitamin D receptor Homo sapiens 145-148 11400211-1 2001 The vitamin D receptor (VDR) binds zinc, and the activity of vitamin D dependent genes in cells is influenced by intracellular zinc concentrations. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 10967105-5 2000 Mutant BAG1L lacking the C-terminal Hsc70-binding domain suppressed (in a concentration-dependent fashion) VDR-mediated trans-activation of vitamin D response element-containing reporter gene plasmids, without altering levels of VDR or endogenous BAG1L protein, suggesting that it operates as a trans-dominant inhibitor of BAG1L. Vitamin D 140-149 vitamin D receptor Homo sapiens 107-110 11085922-1 2000 The vitamin D(3) receptor (VDR), which is the nuclear receptor for 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], acts primarily as a heterodimer with the retinoid X receptor (RXR) and binds preferentially to directly repeated arrangements of two hexameric binding sites with three spacing nucleotides [DR3-type vitamin D response elements (VDREs)]. Vitamin D 4-13 vitamin D receptor Homo sapiens 27-30 11101387-0 2000 Synthesis of vitamin D(3) and calcitriol dimers as potential chemical inducers of vitamin D receptor dimerization. Vitamin D 13-22 vitamin D receptor Homo sapiens 82-100 10976917-1 2000 Previously recognized intracellular proteins with an affinity for vitamin D metabolites include the vitamin D receptor and the cytochrome P-450-based vitamin D metabolizing mixed-function oxidases. Vitamin D 66-75 vitamin D receptor Homo sapiens 100-118 10948206-2 2000 Vitamin D resistance in certain primate genera is associated with the constitutive overexpression of a non-vitamin D receptor (VDR)-related, vitamin D response element-binding protein (VDRE-BP) and squelching of vitamin d-directed transactivation. Vitamin D 0-9 vitamin D receptor Homo sapiens 103-125 10948206-2 2000 Vitamin D resistance in certain primate genera is associated with the constitutive overexpression of a non-vitamin D receptor (VDR)-related, vitamin D response element-binding protein (VDRE-BP) and squelching of vitamin d-directed transactivation. Vitamin D 0-9 vitamin D receptor Homo sapiens 127-130 10948206-3 2000 We used DNA affinity chromatography to purify proteins associated with non-VDR-VDRE binding activity from vitamin d-resistant New World primate cells. Vitamin D 106-115 vitamin D receptor Homo sapiens 75-78 11050002-3 2000 Steroid hormones exert their effect through their cognate nuclear receptors, which for vitamin D metabolites is the vitamin D receptor (VDR). Vitamin D 87-96 vitamin D receptor Homo sapiens 136-139 11050002-3 2000 Steroid hormones exert their effect through their cognate nuclear receptors, which for vitamin D metabolites is the vitamin D receptor (VDR). Vitamin D 87-96 vitamin D receptor Homo sapiens 116-134 11033763-1 2000 The disorders of vitamin D metabolism are inherited metabolic abnormalities involving mutations of the vitamin D receptor or enzymes involved in the metabolism of vitamin D to its biologically active form 1,25-dihydroxyvitamin D. Vitamin D 17-26 vitamin D receptor Homo sapiens 103-121 10825392-1 2000 The vitamin D receptor (VDR) is the nuclear receptor for 1, 25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] that acts as a ligand-dependent transcription factor via combined contact with coactivator proteins (steroid receptor coactivator-1, transcriptional intermediary factor 2, and receptor associated coactivator 3) and specific DNA binding sites [vitamin D response elements (VDREs)]. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 10828304-9 2000 Using this VDR model, the structure-function relationship of highly potent vitamin D analogs was discussed. Vitamin D 75-84 vitamin D receptor Homo sapiens 11-14 10828305-1 2000 Vitamin D analogs in which the triene moiety is replaced by an aromatic ring have been synthesized and their ability to bind to the vitamin D receptor investigated. Vitamin D 0-9 vitamin D receptor Homo sapiens 132-150 10828302-6 2000 Our current understanding of vitamin D physiology and biochemistry suggests that the biological profile of an analog would be determined primarily by its interaction with four classes of proteins: 1) the nuclear vitamin D receptor (VDR) that mediates transcriptional regulation; 2) the metabolic enzymes, primarily the vitamin D-24-hydroxylase but possibly others; 3) serum transporters, mainly vitamin D binding protein (DBP), and perhaps lipoproteins; and 4) a new class of receptors that reside in the plasma membrane and mediate rapid, nongenomic responses. Vitamin D 29-38 vitamin D receptor Homo sapiens 212-230 10828302-6 2000 Our current understanding of vitamin D physiology and biochemistry suggests that the biological profile of an analog would be determined primarily by its interaction with four classes of proteins: 1) the nuclear vitamin D receptor (VDR) that mediates transcriptional regulation; 2) the metabolic enzymes, primarily the vitamin D-24-hydroxylase but possibly others; 3) serum transporters, mainly vitamin D binding protein (DBP), and perhaps lipoproteins; and 4) a new class of receptors that reside in the plasma membrane and mediate rapid, nongenomic responses. Vitamin D 29-38 vitamin D receptor Homo sapiens 232-235 10653974-1 2000 We and others have previously shown that selected vitamin D analogs potentiate the vitamin D receptor (VDR) mediated transcription much more efficiently than the natural hormone itself. Vitamin D 50-59 vitamin D receptor Homo sapiens 83-101 10843188-1 2000 Vitamin D, via its receptor (VDR), inhibits the hormone secretion and proliferation of parathyroid cells. Vitamin D 0-9 vitamin D receptor Homo sapiens 29-32 10773761-1 2000 BACKGROUND/AIMS: It is known that allelic variants of the gene encoding the vitamin-D receptor (VDR) detected by BsmI increase the risk of some advanced malignant tumors, suggesting that such variants may cause functional differences in 1,25(OH)(2) vitamin D(3). Vitamin D 249-258 vitamin D receptor Homo sapiens 76-94 10773761-1 2000 BACKGROUND/AIMS: It is known that allelic variants of the gene encoding the vitamin-D receptor (VDR) detected by BsmI increase the risk of some advanced malignant tumors, suggesting that such variants may cause functional differences in 1,25(OH)(2) vitamin D(3). Vitamin D 249-258 vitamin D receptor Homo sapiens 96-99 10762752-9 2000 Since the cell differentiating effect of vitamin D is considered to be mediated via the vitamin D receptor (VDR), we examined the induction of VDR using reverse transcriptase-polymerase chain reaction (RT-PCR) in both cells. Vitamin D 41-50 vitamin D receptor Homo sapiens 88-106 10762752-9 2000 Since the cell differentiating effect of vitamin D is considered to be mediated via the vitamin D receptor (VDR), we examined the induction of VDR using reverse transcriptase-polymerase chain reaction (RT-PCR) in both cells. Vitamin D 41-50 vitamin D receptor Homo sapiens 108-111 10797570-1 2000 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), the active metabolite of vitamin D, mediates many of its effects through the intranuclear vitamin D receptor (VDR, NR1I1), that belongs to the large superfamily of nuclear receptors. Vitamin D 19-28 vitamin D receptor Homo sapiens 146-164 10797570-1 2000 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), the active metabolite of vitamin D, mediates many of its effects through the intranuclear vitamin D receptor (VDR, NR1I1), that belongs to the large superfamily of nuclear receptors. Vitamin D 19-28 vitamin D receptor Homo sapiens 166-169 10797570-1 2000 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), the active metabolite of vitamin D, mediates many of its effects through the intranuclear vitamin D receptor (VDR, NR1I1), that belongs to the large superfamily of nuclear receptors. Vitamin D 19-28 vitamin D receptor Homo sapiens 171-176 10797570-2 2000 Vitamin D receptor can directly regulate gene expression by binding to vitamin D response elements (VDREs) located in promoter or enhancer regions of various genes. Vitamin D 71-80 vitamin D receptor Homo sapiens 0-18 10698207-2 2000 Although VDR forms stable heterodimer complex with retinoid X receptors (RXRs) on vitamin D-response elements (VDREs), it is still not clear whether VDR/RXR heterodimers are the only VDR complexes responsible for vitamin D-mediated gene transcription. Vitamin D 82-91 vitamin D receptor Homo sapiens 9-12 10698207-2 2000 Although VDR forms stable heterodimer complex with retinoid X receptors (RXRs) on vitamin D-response elements (VDREs), it is still not clear whether VDR/RXR heterodimers are the only VDR complexes responsible for vitamin D-mediated gene transcription. Vitamin D 82-91 vitamin D receptor Homo sapiens 111-114 10698207-2 2000 Although VDR forms stable heterodimer complex with retinoid X receptors (RXRs) on vitamin D-response elements (VDREs), it is still not clear whether VDR/RXR heterodimers are the only VDR complexes responsible for vitamin D-mediated gene transcription. Vitamin D 82-91 vitamin D receptor Homo sapiens 111-114 10698207-2 2000 Although VDR forms stable heterodimer complex with retinoid X receptors (RXRs) on vitamin D-response elements (VDREs), it is still not clear whether VDR/RXR heterodimers are the only VDR complexes responsible for vitamin D-mediated gene transcription. Vitamin D 213-222 vitamin D receptor Homo sapiens 9-12 10698207-7 2000 Our studies suggest the important role of VDR homodimers, in addition to VDR/RXR heterodimers, in vitamin D-induced transactivation. Vitamin D 98-107 vitamin D receptor Homo sapiens 42-45 10698207-7 2000 Our studies suggest the important role of VDR homodimers, in addition to VDR/RXR heterodimers, in vitamin D-induced transactivation. Vitamin D 98-107 vitamin D receptor Homo sapiens 73-76 10687851-2 2000 A human VDR expression plasmid was transfected into HeLa, Saos-2 and MG63 cells with a luciferase reporter gene construct containing the vitamin D responsive element. Vitamin D 137-146 vitamin D receptor Homo sapiens 8-11 11595822-3 2000 However, VDR/RXR heterodimers bind in a transcriptionally unproductive manner and without a defined polarity on certain RA response elements, and under these circumstances vitamin D inhibits the response to RA. Vitamin D 172-181 vitamin D receptor Homo sapiens 9-12 10775803-1 2000 Interference footprinting protocols were utilized to examine the interactions of the vitamin D receptor (VDR) with either a positive or a negative vitamin D response element (VDRE). Vitamin D 85-94 vitamin D receptor Homo sapiens 105-108 10653974-1 2000 We and others have previously shown that selected vitamin D analogs potentiate the vitamin D receptor (VDR) mediated transcription much more efficiently than the natural hormone itself. Vitamin D 50-59 vitamin D receptor Homo sapiens 103-106 10678179-2 2000 We report the 1.8 A resolution crystal structure of the complex between a VDR ligand-binding domain (LBD) construct lacking the highly variable VDR-specific insertion domain and vitamin D. Vitamin D 178-187 vitamin D receptor Homo sapiens 74-77 10597185-5 1999 In breast cancer, low vitamin D levels in serum are correlated with disease progression and bone metastases, a situation also noted in prostate cancer and suggesting the involvement of the VDR. Vitamin D 22-31 vitamin D receptor Homo sapiens 189-192 11073270-14 2000 In a series of elegant experiments [9,10], calcitriol resistance has been related to disturbed genomic effects of active vitamin D because the interaction of the vitamin D receptor ligand complex with vitamin D-responsive elements (VDREs) upstream of vitamin D-regulated genes was disturbed by the action of low molecular weight substances in uraemia, which have not been completely characterized. Vitamin D 121-130 vitamin D receptor Homo sapiens 162-180 10605626-15 1999 Interactions between genetic and environmental factors, including lifestyle, have been investigated initially for the VDR polymorphisms in relation to the response of bone density and turnover to calcium intake and treatment with simple vitamin D and active vitamin D compounds. Vitamin D 237-246 vitamin D receptor Homo sapiens 118-121 10587460-1 1999 The vitamin D receptor (VDR) binds 1,25-dihydroxyvitamin D(3) and mediates its actions on gene transcription by heterodimerizing with retinoid X receptors (RXRs) on direct repeat (DR+3) vitamin D responsive elements (VDREs) located in target genes. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 10605626-15 1999 Interactions between genetic and environmental factors, including lifestyle, have been investigated initially for the VDR polymorphisms in relation to the response of bone density and turnover to calcium intake and treatment with simple vitamin D and active vitamin D compounds. Vitamin D 258-267 vitamin D receptor Homo sapiens 118-121 10540876-1 1999 Action of 1,25-dihydroxyvitamin D, the most active metabolite of vitamin D, is exerted by the nuclear vitamin D receptor (VDR) mediated gene expression. Vitamin D 24-33 vitamin D receptor Homo sapiens 102-120 10612418-2 1999 An active form of vitamin D, 1alpha,25(OH)2D3, serves as a vitamin D receptor (VDR)-specific ligand to activate the expression of a particular set of target genes. Vitamin D 18-27 vitamin D receptor Homo sapiens 59-77 10612418-2 1999 An active form of vitamin D, 1alpha,25(OH)2D3, serves as a vitamin D receptor (VDR)-specific ligand to activate the expression of a particular set of target genes. Vitamin D 18-27 vitamin D receptor Homo sapiens 79-82 10496974-6 1999 Furthermore, we observed that 1,25(OH)(2)D(3)-3-BE significantly decreased the binding of VDR to human osteocalcin vitamin D responsive element (hOCVDRE), as well as the dissociation rate of VDR from hOCVDRE, compared with 1,25(OH)(2)D(3) in COS-1 cells, transiently transfected with a VDR construct. Vitamin D 115-124 vitamin D receptor Homo sapiens 90-93 10496974-6 1999 Furthermore, we observed that 1,25(OH)(2)D(3)-3-BE significantly decreased the binding of VDR to human osteocalcin vitamin D responsive element (hOCVDRE), as well as the dissociation rate of VDR from hOCVDRE, compared with 1,25(OH)(2)D(3) in COS-1 cells, transiently transfected with a VDR construct. Vitamin D 115-124 vitamin D receptor Homo sapiens 148-151 10496974-6 1999 Furthermore, we observed that 1,25(OH)(2)D(3)-3-BE significantly decreased the binding of VDR to human osteocalcin vitamin D responsive element (hOCVDRE), as well as the dissociation rate of VDR from hOCVDRE, compared with 1,25(OH)(2)D(3) in COS-1 cells, transiently transfected with a VDR construct. Vitamin D 115-124 vitamin D receptor Homo sapiens 148-151 10540876-1 1999 Action of 1,25-dihydroxyvitamin D, the most active metabolite of vitamin D, is exerted by the nuclear vitamin D receptor (VDR) mediated gene expression. Vitamin D 24-33 vitamin D receptor Homo sapiens 122-125 10540876-2 1999 Toward the expression of vitamin D function, several steps including 1,25-dihydroxyvitamin D production, tissue specific expression of VDR and transcription of target gene by VDR are involved. Vitamin D 25-34 vitamin D receptor Homo sapiens 135-138 10540876-2 1999 Toward the expression of vitamin D function, several steps including 1,25-dihydroxyvitamin D production, tissue specific expression of VDR and transcription of target gene by VDR are involved. Vitamin D 25-34 vitamin D receptor Homo sapiens 175-178 10540876-6 1999 Furthermore, VDR recruit several coactivators to achieve vitamin D-induced transactivation. Vitamin D 57-66 vitamin D receptor Homo sapiens 13-16 10540876-7 1999 Selective coactivator interaction with VDR may specify the array of biological actions of vitamin D. Vitamin D 90-99 vitamin D receptor Homo sapiens 39-42 10540886-1 1999 Recently, It has become clear that the mutant gene in X-linked hypophosphatemic rickets, vitamin D dependent rickets type I, and vitamin D dependent rickets type II were identified and they were caused by the disorder in the activation of vitamin D and the intracellular defect in vitamin D receptor. Vitamin D 89-98 vitamin D receptor Homo sapiens 281-299 10540886-1 1999 Recently, It has become clear that the mutant gene in X-linked hypophosphatemic rickets, vitamin D dependent rickets type I, and vitamin D dependent rickets type II were identified and they were caused by the disorder in the activation of vitamin D and the intracellular defect in vitamin D receptor. Vitamin D 129-138 vitamin D receptor Homo sapiens 281-299 10446999-6 1999 VDR is functionally active in ATRA-treated Kasumi-1 cells because it efficiently heterodimerizes with retinoid X receptor, binds to a DR3-type vitamin D-responsive element, and activates the transcription of a vitamin D-responsive element-regulated reporter gene. Vitamin D 143-152 vitamin D receptor Homo sapiens 0-3 10446999-6 1999 VDR is functionally active in ATRA-treated Kasumi-1 cells because it efficiently heterodimerizes with retinoid X receptor, binds to a DR3-type vitamin D-responsive element, and activates the transcription of a vitamin D-responsive element-regulated reporter gene. Vitamin D 210-219 vitamin D receptor Homo sapiens 0-3 10224044-6 1999 Taken together, our results strongly suggest that the interplay between the TGF-beta and vitamin D signaling pathways is, at least in part, mediated by the two classes of Smad proteins, which modulate VDR transactivation function both positively and negatively. Vitamin D 89-98 vitamin D receptor Homo sapiens 201-204 10406465-3 1999 We have analyzed the role of GHF-1 and of the vitamin D receptor (VDR) to confer vitamin D responsiveness to the PRL promoter. Vitamin D 46-55 vitamin D receptor Homo sapiens 66-69 10406465-8 1999 Truncation of the last 12 C-terminal amino acids of VDR, which contain the ligand-dependent activation function (AF2), abolishes regulation by vitamin D, suggesting that binding of coactivators to this region mediates ligand-dependent stimulation of the PRL promoter by the receptor. Vitamin D 143-152 vitamin D receptor Homo sapiens 52-55 10406465-9 1999 Indeed, expression of the coactivators, steroid hormone receptor coactivator-1 (SRC-1) and CREB-binding protein (CBP), significantly enhances the stimulatory effect of vitamin D mediated by the wild-type VDR but not by the AF2 mutant receptor. Vitamin D 168-177 vitamin D receptor Homo sapiens 204-207 10336890-8 1999 Binding of RXR/VDR heterodimers to DRs with different transcriptional outcomes may generate selectivity and provide a greater complexity and flexibility to the vitamin D responses. Vitamin D 160-169 vitamin D receptor Homo sapiens 15-18 10223184-3 1999 We determined the expression, DNA binding and transactivation activity of vitamin D3 receptor (VDR) in HBL100 and a vitamin D-sensitive ZR75-1 breast cancer cell line. Vitamin D 74-83 vitamin D receptor Homo sapiens 95-98 10224118-6 1999 As a consequence, overexpression of steroid receptor coactivator-1 increased vitamin D-dependent transactivation by VDR but not by the K246A mutant. Vitamin D 77-86 vitamin D receptor Homo sapiens 116-119 10321413-5 1999 As with vitamin D, the biologic action of paricalcitol is mediated through activation of the vitamin D receptor (VDR). Vitamin D 8-17 vitamin D receptor Homo sapiens 93-111 10052935-9 1999 Removal of two putative direct repeat DNA fragments in this region abolished VDR-RXR alpha-vitamin D response element complex formation. Vitamin D 91-100 vitamin D receptor Homo sapiens 77-80 10234571-11 1999 The results indicate that VDR homodimers are targets of vitamin D analogs with differential effects on C-terminal protein conformation that may partially explain the varied biological responses of these compounds. Vitamin D 56-65 vitamin D receptor Homo sapiens 26-29 9891040-3 1999 We examined interaction of VDR with these coactivators that was induced by several vitamin D analogs, since they exert differential subsets of the biological action of vitamin D through unknown mechanisms. Vitamin D 83-92 vitamin D receptor Homo sapiens 27-30 10037600-2 1999 Vitamin D controls transcription of target genes through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 61-79 10037600-2 1999 Vitamin D controls transcription of target genes through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 81-84 10064337-2 1999 In doing so, we have focused on a dual track as follows: 1) to define the vitamin D3 receptor (VDR) function and structure by examining its various actions at the molecular level; and 2) to isolate and characterize VDR target genes that might be playing key roles in mediating vitamin D growth suppression and differentiation in responsive cells, specifically, the elucidation of vitamin D target genes as they relate to myeloid differentiation. Vitamin D 74-83 vitamin D receptor Homo sapiens 95-98 10064337-2 1999 In doing so, we have focused on a dual track as follows: 1) to define the vitamin D3 receptor (VDR) function and structure by examining its various actions at the molecular level; and 2) to isolate and characterize VDR target genes that might be playing key roles in mediating vitamin D growth suppression and differentiation in responsive cells, specifically, the elucidation of vitamin D target genes as they relate to myeloid differentiation. Vitamin D 277-286 vitamin D receptor Homo sapiens 74-93 10064337-2 1999 In doing so, we have focused on a dual track as follows: 1) to define the vitamin D3 receptor (VDR) function and structure by examining its various actions at the molecular level; and 2) to isolate and characterize VDR target genes that might be playing key roles in mediating vitamin D growth suppression and differentiation in responsive cells, specifically, the elucidation of vitamin D target genes as they relate to myeloid differentiation. Vitamin D 277-286 vitamin D receptor Homo sapiens 95-98 10064337-2 1999 In doing so, we have focused on a dual track as follows: 1) to define the vitamin D3 receptor (VDR) function and structure by examining its various actions at the molecular level; and 2) to isolate and characterize VDR target genes that might be playing key roles in mediating vitamin D growth suppression and differentiation in responsive cells, specifically, the elucidation of vitamin D target genes as they relate to myeloid differentiation. Vitamin D 277-286 vitamin D receptor Homo sapiens 215-218 9891040-3 1999 We examined interaction of VDR with these coactivators that was induced by several vitamin D analogs, since they exert differential subsets of the biological action of vitamin D through unknown mechanisms. Vitamin D 168-177 vitamin D receptor Homo sapiens 27-30 9891040-6 1999 Thus, the present findings suggest that the structure of VDR is altered in a vitamin D analog-specific way, resulting in selective interactions of VDR with coactivators. Vitamin D 77-86 vitamin D receptor Homo sapiens 57-60 9891040-6 1999 Thus, the present findings suggest that the structure of VDR is altered in a vitamin D analog-specific way, resulting in selective interactions of VDR with coactivators. Vitamin D 77-86 vitamin D receptor Homo sapiens 147-150 9891040-7 1999 Such selective interaction of coactivators with VDR may specify the array of biological actions of a vitamin D analog like OCT, possibly through activating a particular set of target gene promoters. Vitamin D 101-110 vitamin D receptor Homo sapiens 48-51 10323682-4 1999 Vitamin D analogues with poor affinity for the vitamin D receptor were found to effectively stimulate PI turnover, suggesting the presence of a unique vitamin D receptor in the BLM. Vitamin D 0-9 vitamin D receptor Homo sapiens 47-65 10079704-1 1999 Calcitriol, the active metabolite of vitamin D, is a steroid hormone that regulates calcium metabolism and cell differentiation by interacting with its nuclear receptor--the vitamin D receptor (VDR)--and by stimulating gene transcription. Vitamin D 37-46 vitamin D receptor Homo sapiens 174-192 10079704-1 1999 Calcitriol, the active metabolite of vitamin D, is a steroid hormone that regulates calcium metabolism and cell differentiation by interacting with its nuclear receptor--the vitamin D receptor (VDR)--and by stimulating gene transcription. Vitamin D 37-46 vitamin D receptor Homo sapiens 194-197 10609868-1 1999 Vitamin A (retinol) and vitamin D are lipid soluble vitamins that are precursors of the nuclear hormones all-trans retinoic acid (RA) and 1alpha,25-dihydroxyvitamin D3 (VD) that bind with high affinity to their cognate nuclear receptors, referred to as retinoic acid receptor (RAR) and vitamin D receptor (VDR). Vitamin D 24-33 vitamin D receptor Homo sapiens 286-304 10609868-1 1999 Vitamin A (retinol) and vitamin D are lipid soluble vitamins that are precursors of the nuclear hormones all-trans retinoic acid (RA) and 1alpha,25-dihydroxyvitamin D3 (VD) that bind with high affinity to their cognate nuclear receptors, referred to as retinoic acid receptor (RAR) and vitamin D receptor (VDR). Vitamin D 24-33 vitamin D receptor Homo sapiens 306-309 10052463-1 1999 The control of gene transcription by vitamin D compounds is initiated by binding to the VDR, which enhances the receptor"s ability to heterodimerize to RXR, interact with response elements in target genes and attract components of the transcriptional initiation complex. Vitamin D 37-46 vitamin D receptor Homo sapiens 88-91 10323682-4 1999 Vitamin D analogues with poor affinity for the vitamin D receptor were found to effectively stimulate PI turnover, suggesting the presence of a unique vitamin D receptor in the BLM. Vitamin D 0-9 vitamin D receptor Homo sapiens 151-169 9892040-1 1998 The vitamin D system is unique in that distinct calcium homeostatic functions and cell growth regulatory activities are mediated through a single ligand, calcitriol, acting through a specific receptor exhibiting ubiquitous tissue expression, the vitamin D receptor (VDR). Vitamin D 4-13 vitamin D receptor Homo sapiens 246-264 9881643-2 1998 The VDR, bound to 1alpha,25(OH)2D3, forms a heterodimer with a nuclear accessory factor, retinoid X receptor (RXR), and the complex subsequently binds to specific nucleotide sequences or a vitamin D-responsive element (VDRE) to induce gene transcriptions. Vitamin D 189-198 vitamin D receptor Homo sapiens 4-7 9892040-1 1998 The vitamin D system is unique in that distinct calcium homeostatic functions and cell growth regulatory activities are mediated through a single ligand, calcitriol, acting through a specific receptor exhibiting ubiquitous tissue expression, the vitamin D receptor (VDR). Vitamin D 4-13 vitamin D receptor Homo sapiens 266-269 9797477-9 1998 The ability of the two VDR forms to transactivate target genes was investigated using three different vitamin D responsive luciferase reporter constructs: 24-hydroxylase, osteocalcin, and osteopontin. Vitamin D 102-111 vitamin D receptor Homo sapiens 23-26 9808140-1 1998 Most of the biological actions of 1,25(OH)2D3, the hormonal form of vitamin D, are mediated by the vitamin D receptor (VDR), a member of the steroid/thyroid receptor superfamily. Vitamin D 68-77 vitamin D receptor Homo sapiens 99-117 9808140-1 1998 Most of the biological actions of 1,25(OH)2D3, the hormonal form of vitamin D, are mediated by the vitamin D receptor (VDR), a member of the steroid/thyroid receptor superfamily. Vitamin D 68-77 vitamin D receptor Homo sapiens 119-122 9751364-1 1998 PURPOSE: Reports in the osteoporosis literature demonstrating the increased activity of specific alleles of the vitamin D receptor and epidemiological data linking vitamin D levels with prostate cancer have stimulated research into possible associations between vitamin D receptor genotype and the development of prostate cancer. Vitamin D 112-121 vitamin D receptor Homo sapiens 262-280 9761785-12 1998 In contrast, a VDR genotype, which has been associated with decreased serum levels of the active hormonal form of vitamin D and increased risk for certain cancers, seemed to be related to severity of CAD (P=0.025). Vitamin D 114-123 vitamin D receptor Homo sapiens 15-18 18406281-2 1998 The vitamin D endocrine system plays a fundamental role in the regulation of Ca(2+) homeostasis, and mutations affecting genes implicated in vitamin D metabolism or vitamin D receptor (VDR) functions are responsible for severe alterations in skeletal growth. Vitamin D 4-13 vitamin D receptor Homo sapiens 165-183 9731705-3 1998 Previous studies indicated that when MCF-7 cells are transfected with the rat CaBP9k VDRE ligated to the thymidine kinase promoter and treated with both 1,25-(OH)2D3 and T3 there is an enhancement of the response observed with 1,25-(OH)2D3 alone, suggesting direct cross-talk between thyroid hormone and the vitamin D endocrine system and activation via the formation of vitamin D receptor (VDR)-thyroid hormone receptor (TR) heterodimers. Vitamin D 308-317 vitamin D receptor Homo sapiens 85-88 10101442-10 1998 Results from this study suggest that faster bone mineral loss and more exaggerated disturbances of vitamin D metabolism are present in haemodialyzed uraemic patients with BB than bb genotype of VDR. Vitamin D 99-108 vitamin D receptor Homo sapiens 194-197 9753621-1 1998 Previous studies have shown that the binding affinity of a vitamin D analogue for the vitamin D receptor (VDR) does not correlate with the biological potency of the compound. Vitamin D 59-68 vitamin D receptor Homo sapiens 86-104 9753621-1 1998 Previous studies have shown that the binding affinity of a vitamin D analogue for the vitamin D receptor (VDR) does not correlate with the biological potency of the compound. Vitamin D 59-68 vitamin D receptor Homo sapiens 106-109 9753621-2 1998 In the present investigation the vitamin D analogue GS 1500, which is characterised by an altered stereochemistry at carbon C-20 (20-epi) and an aromatic ring in the side chain, was studied with respect to its interaction with the VDR. Vitamin D 33-42 vitamin D receptor Homo sapiens 231-234 9753621-5 1998 At the level of VDR interaction with the vitamin D responsive element, GS 1500 did induce a binding complex at a lower concentration than 1,25(OH)2D3, which may help explain the difference in potency. Vitamin D 41-50 vitamin D receptor Homo sapiens 16-19 18406281-2 1998 The vitamin D endocrine system plays a fundamental role in the regulation of Ca(2+) homeostasis, and mutations affecting genes implicated in vitamin D metabolism or vitamin D receptor (VDR) functions are responsible for severe alterations in skeletal growth. Vitamin D 4-13 vitamin D receptor Homo sapiens 185-188 9691832-1 1998 The active metabolite of vitamin D, 1,25 (OH)2D3, exerts its cell cycle regulating effects via binding to VDR (Vitamin D Receptor). Vitamin D 25-34 vitamin D receptor Homo sapiens 106-109 9682036-3 1998 VDR is a ligand-inducible transcription factor which heterodimerizes with retinoid X receptor (RXR) and binds as a heterodimer to vitamin D-responsive elements (VDREs) in the promoter region of vitamin-D responsive genes, ultimately leading to their increased transcription. Vitamin D 130-139 vitamin D receptor Homo sapiens 0-3 9682036-3 1998 VDR is a ligand-inducible transcription factor which heterodimerizes with retinoid X receptor (RXR) and binds as a heterodimer to vitamin D-responsive elements (VDREs) in the promoter region of vitamin-D responsive genes, ultimately leading to their increased transcription. Vitamin D 194-203 vitamin D receptor Homo sapiens 0-3 9682036-6 1998 These interactions have a role in linking the VDR-RXR heterodimer to the transcriptional pre-initiation complex (PIC) and in regulating the transcription of vitamin D-dependent genes. Vitamin D 157-166 vitamin D receptor Homo sapiens 46-49 9682036-8 1998 The complex interplay that occurs between VDR and these various factors to determine the overall transcriptional activity of vitamin D-responsive genes will be summarized. Vitamin D 125-134 vitamin D receptor Homo sapiens 42-45 9783909-1 1998 To characterize further the function of the intracellular vitamin D receptor (VDR), we have developed stable transfectant variants of a vitamin D-responsive cell line (U937) which express either decreased or increased numbers of VDR. Vitamin D 58-67 vitamin D receptor Homo sapiens 78-81 9691832-1 1998 The active metabolite of vitamin D, 1,25 (OH)2D3, exerts its cell cycle regulating effects via binding to VDR (Vitamin D Receptor). Vitamin D 25-34 vitamin D receptor Homo sapiens 111-129 9691832-3 1998 The VDR-RXR heterodimer binds to promoter regions of cell cycle regulating genes through a vitamin D response element (VDRE). Vitamin D 91-100 vitamin D receptor Homo sapiens 4-7 9702072-4 1998 Vitamin D-dependent rickets type II is associated with the abnormality of the VDR function, leading to target organ resistance to 1,25(OH)2D3. Vitamin D 0-9 vitamin D receptor Homo sapiens 78-81 9690035-2 1998 An active form of vitamin D acting as a ligand specific vitamin D receptor (VDR), 1 alpha,25(OH)2D3, is biosynthesized from cholesterol, and during this biosynthesis a renal 25-hydroxylation at the final stage by 25-hydroxyvitamin D3 1 alpha-hydroxylase is critical. Vitamin D 18-27 vitamin D receptor Homo sapiens 56-74 9690035-2 1998 An active form of vitamin D acting as a ligand specific vitamin D receptor (VDR), 1 alpha,25(OH)2D3, is biosynthesized from cholesterol, and during this biosynthesis a renal 25-hydroxylation at the final stage by 25-hydroxyvitamin D3 1 alpha-hydroxylase is critical. Vitamin D 18-27 vitamin D receptor Homo sapiens 76-79 9639512-5 1998 A heterodimer consisting of the retinoid X receptor and the VDR binds to vitamin D responsive elements on genes regulated by vitamin D. Vitamin D 73-82 vitamin D receptor Homo sapiens 60-63 9639512-5 1998 A heterodimer consisting of the retinoid X receptor and the VDR binds to vitamin D responsive elements on genes regulated by vitamin D. Vitamin D 125-134 vitamin D receptor Homo sapiens 60-63 9600069-6 1998 Our results strongly suggest the existence of a feedback mechanism in that UVB initiates vitamin D synthesis in keratinocytes and at the same time limits VDR abundance. Vitamin D 89-98 vitamin D receptor Homo sapiens 154-157 9556566-0 1998 A negative vitamin D response DNA element in the human parathyroid hormone-related peptide gene binds to vitamin D receptor along with Ku antigen to mediate negative gene regulation by vitamin D. Vitamin D 11-20 vitamin D receptor Homo sapiens 105-123 9556566-8 1998 These results indicate that nVDREhPTHrP interacts with Ku antigen in addition to VDR to mediate gene suppression by vitamin D. Vitamin D 116-125 vitamin D receptor Homo sapiens 29-32 9624222-13 1998 Variation in vitamin D requirements could arise from genetic differences in vitamin D processing since bone density can vary with vitamin D-receptor genotype. Vitamin D 13-22 vitamin D receptor Homo sapiens 130-148 9579411-8 1998 Since VDR mRNA expression has been already reported in human brain tumors, our data imply that the identification of VDR expression could become a prerequisite in any strategy of glioma treatment with vitamin D analogs. Vitamin D 201-210 vitamin D receptor Homo sapiens 117-120 9624222-13 1998 Variation in vitamin D requirements could arise from genetic differences in vitamin D processing since bone density can vary with vitamin D-receptor genotype. Vitamin D 76-85 vitamin D receptor Homo sapiens 130-148 9440810-1 1998 The vitamin D receptor (VDR) binds to the vitamin D response element (VDRE) and mediates the effects of the biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], on gene expression. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 9586948-1 1998 The biological active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), mediates most of its actions through the intracellular vitamin D receptor (VDR). Vitamin D 30-39 vitamin D receptor Homo sapiens 136-154 9586948-1 1998 The biological active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), mediates most of its actions through the intracellular vitamin D receptor (VDR). Vitamin D 30-39 vitamin D receptor Homo sapiens 156-159 9586948-2 1998 VDR binds to vitamin D responsive elements (VDREs) in the promoter region of responsive genes and regulates transcription. Vitamin D 13-22 vitamin D receptor Homo sapiens 0-3 9495519-1 1998 Mutations in the vitamin D receptor (VDR) gene have been shown to cause hereditary vitamin D-resistant rickets (HVDRR). Vitamin D 17-26 vitamin D receptor Homo sapiens 37-40 9597143-8 1998 The active form of vitamin D has immunomodulatory effects, and allelic variants of the vitamin D receptor appear to be associated with differential susceptibility to several infectious diseases. Vitamin D 19-28 vitamin D receptor Homo sapiens 87-105 9792954-14 1998 These results indicate that 1,25(OH)2D3 upregulated PTH/PTHrP receptor expression at both mRNA and protein levels in a manner consistent with VDR/RXR heterodimers transactivating the PTH/PTHrP receptor gene by binding a vitamin D response element in the PTH/PTHrP gene. Vitamin D 220-229 vitamin D receptor Homo sapiens 142-145 9440810-1 1998 The vitamin D receptor (VDR) binds to the vitamin D response element (VDRE) and mediates the effects of the biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], on gene expression. Vitamin D 42-51 vitamin D receptor Homo sapiens 4-22 9440810-1 1998 The vitamin D receptor (VDR) binds to the vitamin D response element (VDRE) and mediates the effects of the biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], on gene expression. Vitamin D 42-51 vitamin D receptor Homo sapiens 24-27 9379138-4 1997 In hereditary hypocalcemic vitamin D-resistant rickets (HVDRR), natural mutations in human VDR that confer patients with tissue insensitivity to 1,25(OH)2D3 are particularly instructive in revealing VDR structure function relationships. Vitamin D 27-36 vitamin D receptor Homo sapiens 57-60 9431991-5 1997 However, only those metabolites which were able to transactivate a classical vitamin D response element had the ability to repress IL-8 promoter activation, suggesting that this repression is mediated via vitamin D receptor (VDR). Vitamin D 77-86 vitamin D receptor Homo sapiens 205-223 9431991-5 1997 However, only those metabolites which were able to transactivate a classical vitamin D response element had the ability to repress IL-8 promoter activation, suggesting that this repression is mediated via vitamin D receptor (VDR). Vitamin D 77-86 vitamin D receptor Homo sapiens 225-228 9284761-1 1997 Hereditary vitamin D resistant rickets has been associated with a number of mutations within the DNA and ligand binding domains of vitamin D receptors (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 131-150 9284761-1 1997 Hereditary vitamin D resistant rickets has been associated with a number of mutations within the DNA and ligand binding domains of vitamin D receptors (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 152-155 9379138-4 1997 In hereditary hypocalcemic vitamin D-resistant rickets (HVDRR), natural mutations in human VDR that confer patients with tissue insensitivity to 1,25(OH)2D3 are particularly instructive in revealing VDR structure function relationships. Vitamin D 27-36 vitamin D receptor Homo sapiens 91-94 9379138-14 1997 The above events, including bridging by coactivators to the TATA binding protein and associated factors, may position VDR such that it is able to attract TFIIB and the balance of the RNA polymerase II transcription machinery, culminating in repeated transcriptional initiation of VDRE-containing, vitamin D target genes. Vitamin D 297-306 vitamin D receptor Homo sapiens 118-121 9258754-0 1997 The effect of vitamin D supplementation on the bone mineral density of the femoral neck is associated with vitamin D receptor genotype. Vitamin D 14-23 vitamin D receptor Homo sapiens 107-125 9815816-0 1997 Three synthetic vitamin D analogues induce prostate-specific acid phosphatase and prostate-specific antigen while inhibiting the growth of human prostate cancer cells in a vitamin D receptor-dependent fashion. Vitamin D 16-25 vitamin D receptor Homo sapiens 172-190 9265628-6 1997 Gel mobility shift analyses of the VDR DBD with several vitamin D response elements (VDREs) in the absence of accessory proteins such as retinoic acid receptor, showed that VDR DBD was able to form a protein/VDRE DNA structural complex. Vitamin D 56-65 vitamin D receptor Homo sapiens 35-38 9265628-6 1997 Gel mobility shift analyses of the VDR DBD with several vitamin D response elements (VDREs) in the absence of accessory proteins such as retinoic acid receptor, showed that VDR DBD was able to form a protein/VDRE DNA structural complex. Vitamin D 56-65 vitamin D receptor Homo sapiens 85-88 9258754-10 1997 The VDR genotype-dependent effect of vitamin D supplementation in these elderly subjects suggest a functional involvement of VDR gene variants in determining BMD. Vitamin D 37-46 vitamin D receptor Homo sapiens 4-7 9258754-10 1997 The VDR genotype-dependent effect of vitamin D supplementation in these elderly subjects suggest a functional involvement of VDR gene variants in determining BMD. Vitamin D 37-46 vitamin D receptor Homo sapiens 125-128 9204985-8 1997 These co-operative effects may occur as a consequence of molecular events which involve the transcription by vitamin D receptors (VDR) of genes required for the responsiveness of immature cells to factors such as GM-CSF, and place these and other related vitamin D analogues as potential therapeutic agents in the treatment of leukaemia. Vitamin D 109-118 vitamin D receptor Homo sapiens 130-133 9263679-1 1997 Vitamin D acts on the genome via its active metabolite, calcitriol, which is bound to its nuclear receptor (vitamin D receptor) and a DNA response element. Vitamin D 0-9 vitamin D receptor Homo sapiens 108-126 9169350-6 1997 The extent of vitamin D-dependent transcriptional activation of a reporter construct under the control of a vitamin D response element in transfected HeLa cells was approximately 1.7-fold greater for the m type VDR than for the M type protein. Vitamin D 14-23 vitamin D receptor Homo sapiens 211-214 9200691-1 1997 1alpha,25-Dihydroxyvitamin D3, the vitamin D hormone, manifests its diverse biological properties by specifically binding to the vitamin D sterol-binding pockets of vitamin D-binding protein (DBP) and vitamin D receptor. Vitamin D 19-28 vitamin D receptor Homo sapiens 201-219 9210418-9 1997 Vitamin D responsiveness of the NaPi-3 promoter was also detected in COS-7 cells co-transfected with a human vitamin D receptor expression vector. Vitamin D 0-9 vitamin D receptor Homo sapiens 109-127 9169350-6 1997 The extent of vitamin D-dependent transcriptional activation of a reporter construct under the control of a vitamin D response element in transfected HeLa cells was approximately 1.7-fold greater for the m type VDR than for the M type protein. Vitamin D 108-117 vitamin D receptor Homo sapiens 211-214 9121440-2 1997 The receptors for 9-cis retinoic acid and 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], RXR and VDR, respectively, as members of this superfamily, form a heterodimeric complex and bind cooperatively to vitamin D responsive elements (VDREs) to activate or repress the transcription of a multitude of genes which regulate a variety of physiological functions. Vitamin D 56-65 vitamin D receptor Homo sapiens 90-93 9058382-0 1997 Analysis of vitamin D analog-induced heterodimerization of vitamin D receptor with retinoid X receptor using the yeast two-hybrid system. Vitamin D 12-21 vitamin D receptor Homo sapiens 59-77 9165580-2 1997 Vitamin D analogues exert its effect by interacting with the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 61-79 9165580-2 1997 Vitamin D analogues exert its effect by interacting with the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 81-84 9165580-11 1997 Our study shows that TCC cells possess the VDR receptor which may make them capable to respond to stimulation with vitamin D, but functional studies of vitamin D"s effect on TCC cells in vitro are necessary before the efficacy of treatment with vitamin D analogues in TCC can be evaluated in patients. Vitamin D 115-124 vitamin D receptor Homo sapiens 43-46 9165580-11 1997 Our study shows that TCC cells possess the VDR receptor which may make them capable to respond to stimulation with vitamin D, but functional studies of vitamin D"s effect on TCC cells in vitro are necessary before the efficacy of treatment with vitamin D analogues in TCC can be evaluated in patients. Vitamin D 152-161 vitamin D receptor Homo sapiens 43-46 9165580-11 1997 Our study shows that TCC cells possess the VDR receptor which may make them capable to respond to stimulation with vitamin D, but functional studies of vitamin D"s effect on TCC cells in vitro are necessary before the efficacy of treatment with vitamin D analogues in TCC can be evaluated in patients. Vitamin D 152-161 vitamin D receptor Homo sapiens 43-46 9099905-0 1997 The noncalcemic vitamin D analogues EB1089 and 22-oxacalcitriol interact with the vitamin D receptor and suppress parathyroid hormone-related peptide gene expression. Vitamin D 16-25 vitamin D receptor Homo sapiens 82-100 9058382-5 1997 We used the yeast two-hybrid system to evaluate a series of six vitamin D analogs for their ability to induce VDR-RXR heterodimerization. Vitamin D 64-73 vitamin D receptor Homo sapiens 110-113 9013769-2 1997 However, the functional relevance of the VDR-TFIIB interaction in vitamin D-mediated transcription is not well understood. Vitamin D 66-75 vitamin D receptor Homo sapiens 41-44 9191975-1 1997 We previously reported that 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] activates the human osteocalcin gene (hOC) through vitamin D receptor (VDR) and vitamin D responsive element (VDRE) in the same manner as 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2 D3] [17]. Vitamin D 44-53 vitamin D receptor Homo sapiens 122-140 9191975-1 1997 We previously reported that 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] activates the human osteocalcin gene (hOC) through vitamin D receptor (VDR) and vitamin D responsive element (VDRE) in the same manner as 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2 D3] [17]. Vitamin D 44-53 vitamin D receptor Homo sapiens 142-145 9013769-5 1997 This N-terminal, VDR-interactive domain functioned as a selective, dominant-negative inhibitor of vitamin D-mediated transcription. Vitamin D 98-107 vitamin D receptor Homo sapiens 17-20 9013769-9 1997 Mechanistically, these data establish a functional role for the N terminus of TFIIB in VDR-mediated transcription, and they allude to a role for unliganded VDR in targeting TFIIB to the promoter regions of vitamin D-responsive target genes. Vitamin D 206-215 vitamin D receptor Homo sapiens 87-90 9013769-9 1997 Mechanistically, these data establish a functional role for the N terminus of TFIIB in VDR-mediated transcription, and they allude to a role for unliganded VDR in targeting TFIIB to the promoter regions of vitamin D-responsive target genes. Vitamin D 206-215 vitamin D receptor Homo sapiens 156-159 8841046-10 1996 Analysis of VDR alleles may prove useful in selecting the vitamin D therapy for osteopenia before treatment. Vitamin D 58-67 vitamin D receptor Homo sapiens 12-15 9005998-0 1997 Hereditary vitamin D resistant rickets caused by a novel mutation in the vitamin D receptor that results in decreased affinity for hormone and cellular hyporesponsiveness. Vitamin D 11-20 vitamin D receptor Homo sapiens 73-91 9005998-1 1997 Mutations in the vitamin D receptor (VDR) result in target organ resistance to 1alpha,25-dihydroxyvitamin D [1,25(OH)2D3], the active form of vitamin D, and cause hereditary 1,25-dihydroxyvitamin D resistant rickets (HVDRR). Vitamin D 17-26 vitamin D receptor Homo sapiens 37-40 9010343-1 1996 The nature of the DNA binding interactions of the human vitamin D receptor (hVDR) with the murine osteopontin vitamin D response element (mOP VDRE) was examined. Vitamin D 56-65 vitamin D receptor Homo sapiens 76-80 9010343-12 1996 From these results we infer that homodimers of the hVDR which respond with enhanced DNA binding to particular vitamin D response elements when exposed to 1,25-(OH)2D3 are possible. Vitamin D 110-119 vitamin D receptor Homo sapiens 51-55 8990171-9 1997 Our results suggest that YY1 regulates vitamin D enhancement of osteocalcin gene transcription in vivo by interfering with the interactions of the VDR with both the VDRE and TFIIB. Vitamin D 39-48 vitamin D receptor Homo sapiens 147-150 8961271-2 1996 Two novel point mutations (I314S and R391C) identified in the hormone-binding domain of the human vitamin D receptor (VDR) from patients with hereditary hypocalcemic vitamin D-resistant rickets confer the receptor with sharply reduced 1,25-(OH)2D3-dependent transactivation. Vitamin D 98-107 vitamin D receptor Homo sapiens 118-121 9159226-0 1996 New mechanisms of regulation of the genomic actions of vitamin D in bone cells: interaction of the vitamin D receptor with non-classical response elements and with the multifunctional protein, calreticulin. Vitamin D 55-64 vitamin D receptor Homo sapiens 99-117 9159226-2 1996 The vitamin D receptor (VDR) forms heterodimers with retinoid X receptors (RXRs) and the dimer then interacts with its cognate binding site, termed vitamin D response element (VDRE), to affect the transcription of target genes. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 8709103-1 1996 Two proteins play important roles in the expression of vitamin D function: the specific nuclear receptor protein (vitamin D receptor, VDR) and the transport protein (vitamin D binding protein, DBP). Vitamin D 55-64 vitamin D receptor Homo sapiens 114-132 8678897-2 1996 One such analog is the vitamin D2 metabolite, 1 alpha,24(S)-dihydroxyvitamin D2, which binds strongly to the vitamin D receptor and induces vitamin D-dependent gene expression in vitro. Vitamin D 23-32 vitamin D receptor Homo sapiens 109-127 8709103-1 1996 Two proteins play important roles in the expression of vitamin D function: the specific nuclear receptor protein (vitamin D receptor, VDR) and the transport protein (vitamin D binding protein, DBP). Vitamin D 55-64 vitamin D receptor Homo sapiens 134-137 8681462-1 1996 The physiologically active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D3 (calcitriol), induces gap junctional intercellular communication in human skin fibroblasts 161BR at a concentration of 10(-7) M. In human skin fibroblasts, FIB5, devoid of a functional nuclear vitamin D receptor (VDR), there is no effect on gap junctional intercellular communication. Vitamin D 41-50 vitamin D receptor Homo sapiens 275-293 8687373-1 1996 The biologically active metabolite of vitamin D (cholecalciferol), i.e. 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], is a secosteroid hormone whose mode of action involves stereospecific interaction with an intracellular receptor protein (vitamin D receptor; VDR). Vitamin D 38-47 vitamin D receptor Homo sapiens 234-252 8687373-1 1996 The biologically active metabolite of vitamin D (cholecalciferol), i.e. 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], is a secosteroid hormone whose mode of action involves stereospecific interaction with an intracellular receptor protein (vitamin D receptor; VDR). Vitamin D 38-47 vitamin D receptor Homo sapiens 254-257 8687373-6 1996 The VDR binds to vitamin D-responsive elements (VDREs) in the 5" flanking region of target genes. Vitamin D 17-26 vitamin D receptor Homo sapiens 4-7 8681462-0 1996 Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear vitamin D receptor. Vitamin D 59-68 vitamin D receptor Homo sapiens 246-264 8681462-0 1996 Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear vitamin D receptor. Vitamin D 182-191 vitamin D receptor Homo sapiens 246-264 8681462-1 1996 The physiologically active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D3 (calcitriol), induces gap junctional intercellular communication in human skin fibroblasts 161BR at a concentration of 10(-7) M. In human skin fibroblasts, FIB5, devoid of a functional nuclear vitamin D receptor (VDR), there is no effect on gap junctional intercellular communication. Vitamin D 41-50 vitamin D receptor Homo sapiens 295-298 8650247-5 1996 Responses to vitamin D treatment may also be predicted by vitamin D receptor allelic analysis, though the currently proposed allelic patterns are yet far from being widely accepted. Vitamin D 13-22 vitamin D receptor Homo sapiens 58-76 8761938-8 1996 In addition, the full-length VDR fusion protein was shown by gel shift analysis to bind weakly to the human osteocalcin gene vitamin D response element, an interaction greatly facilitated by addition of RXR alpha. Vitamin D 125-134 vitamin D receptor Homo sapiens 29-32 8752659-1 1996 The biologic effects of the vitamin D hormone 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are believed to be mediated by an intracellular vitamin D receptor, which after ligand binding acts as a transcription factor modulating expression of a variety of genes. Vitamin D 28-37 vitamin D receptor Homo sapiens 133-151 8752663-8 1996 The inhibition of collagen gel contraction by 1,25-D3 is supposed to be mediated by the vitamin D receptor because a functional vitamin D receptor is required, and vitamin D metabolites with low affinity to the vitamin D receptor were inactive. Vitamin D 88-97 vitamin D receptor Homo sapiens 128-146 8752663-8 1996 The inhibition of collagen gel contraction by 1,25-D3 is supposed to be mediated by the vitamin D receptor because a functional vitamin D receptor is required, and vitamin D metabolites with low affinity to the vitamin D receptor were inactive. Vitamin D 88-97 vitamin D receptor Homo sapiens 128-146 8650247-6 1996 The outlook for vitamin D treatment for osteoporosis may require insight into vitamin D receptor, not only for vitamin D"s given form, but also for a possible future form designed to intervene at the genomic level. Vitamin D 16-25 vitamin D receptor Homo sapiens 78-96 8726384-1 1996 The effects of the active metabolite of vitamin D, 1,25 dihydroxyvitamin D3 (1,25D), are mediated via the vitamin D receptor (VDR). Vitamin D 40-49 vitamin D receptor Homo sapiens 106-124 8622969-4 1996 Replacement of Ser-208 with glycine or alanine indicates that phosphorylation of hVDR at Ser-208 is not obligatory for 1,25(OH)2D3 action, but coexpression of wild-type hVDR and CK-11 elicits a dose-dependent enhancement of 1,25(OH)2D3-stimulated transcription of a vitamin D responsive element reporter construct. Vitamin D 266-275 vitamin D receptor Homo sapiens 81-85 8651937-9 1996 In gel shift assays, the binding of vitamin D receptor to the composite AP-1 plus vitamin-D responsive promoter region of the human osteocalcin gene after EB 1089 treatment was stronger and longer-lasting than after calcitriol treatment. Vitamin D 82-91 vitamin D receptor Homo sapiens 36-54 8726384-1 1996 The effects of the active metabolite of vitamin D, 1,25 dihydroxyvitamin D3 (1,25D), are mediated via the vitamin D receptor (VDR). Vitamin D 40-49 vitamin D receptor Homo sapiens 126-129 9156521-1 1996 The receptor for the active metabolite of vitamin D, 1,25(OH)(2)D(3), known as the vitamin D receptor (VDR), belongs to the steroid hormone nuclear receptor superfamily. Vitamin D 42-51 vitamin D receptor Homo sapiens 83-101 9156521-1 1996 The receptor for the active metabolite of vitamin D, 1,25(OH)(2)D(3), known as the vitamin D receptor (VDR), belongs to the steroid hormone nuclear receptor superfamily. Vitamin D 42-51 vitamin D receptor Homo sapiens 103-106 8622645-6 1996 Although VDR can bind as a homodimer to the osteopontin gene vitamin D response element, we find that a RXR-VDR heterodimer must be the transactivating species from the element in vivo, since RXR enhances and 9-cis RA and other RXR-specific ligands attenuate this induction. Vitamin D 61-70 vitamin D receptor Homo sapiens 9-12 9627686-7 1996 Because RXR heterodimerizes with either RARs or VDR, it functions as a key protein in the overall retinoid or vitamin D response of a given biological system. Vitamin D 110-119 vitamin D receptor Homo sapiens 48-51 9627691-0 1996 The anti-proliferative and differentiation-inducing effects of vitamin D analogs are not determined by the binding affinity for the vitamin D receptor alone. Vitamin D 63-72 vitamin D receptor Homo sapiens 132-150 8593831-7 1996 In addition, vitamin D-resistant cell nuclear extract contained a protein(s) which was bound specifically to the VDRE and was capable of completely inhibiting VDR-RXR-VDRE complex formation; these effects were not demonstrated with nuclear extract from the wild type cell line or with the post-nuclear extract of the vitamin D-resistant cell line. Vitamin D 13-22 vitamin D receptor Homo sapiens 113-116 8833658-0 1996 Vitamin D receptor binding to the negative human parathyroid hormone vitamin D response element does not require the retinoid x receptor. Vitamin D 69-78 vitamin D receptor Homo sapiens 0-18 8593831-7 1996 In addition, vitamin D-resistant cell nuclear extract contained a protein(s) which was bound specifically to the VDRE and was capable of completely inhibiting VDR-RXR-VDRE complex formation; these effects were not demonstrated with nuclear extract from the wild type cell line or with the post-nuclear extract of the vitamin D-resistant cell line. Vitamin D 317-326 vitamin D receptor Homo sapiens 113-116 8593831-8 1996 We conclude that a VDRE-binding protein(s), distinct from IDBP and present in nuclear extract of cells from a prototypical vitamin D-resistant NWP, is capable of inhibiting normal VDR-RXR heterodimer binding to the VDRE. Vitamin D 123-132 vitamin D receptor Homo sapiens 19-22 8566748-1 1996 The hormonal form of vitamin D, 1,25-dihydroxyvitamin D3, acting through its cognate nuclear receptor (vitamin D3 receptor, VDR) will induce myeloid leukemic cell lines to terminally differentiate into monocytes/macrophages. Vitamin D 21-30 vitamin D receptor Homo sapiens 103-122 8566748-1 1996 The hormonal form of vitamin D, 1,25-dihydroxyvitamin D3, acting through its cognate nuclear receptor (vitamin D3 receptor, VDR) will induce myeloid leukemic cell lines to terminally differentiate into monocytes/macrophages. Vitamin D 21-30 vitamin D receptor Homo sapiens 124-127 8566748-5 1996 Furthermore, we show that p21 is transcriptionally induced by 1,25-dihydroxyvitamin D3 in a VDR-dependent, but not p53-dependent, manner, and we identify a functional vitamin D response element in the p21 promoter. Vitamin D 76-85 vitamin D receptor Homo sapiens 92-95 8614417-9 1995 These results suggest that vitamin D analogs do indeed confer biological effects by acting directly and differentially at the level of VDR, and that specific vitamin D analogs can act on distinct receptor functions. Vitamin D 27-36 vitamin D receptor Homo sapiens 135-138 8858258-1 1996 In addition to a role in calcium and phosphate homeostasis other vitamin D receptor (VDR) mediated effects have been discovered during the past few years for the biologically active metabolite of vitamin D, 1,25(OH)2D3. Vitamin D 65-74 vitamin D receptor Homo sapiens 85-88 7489414-9 1995 As the b allele has been linked to decreased transcriptional activity or messenger RNA stability, reduced VDR expression may impede regulatory actions of vitamin D and may contribute to parathyroid tumorigenesis in these patients. Vitamin D 154-163 vitamin D receptor Homo sapiens 106-109 8650307-7 1996 Advances in our understanding of the vitamin D mechanism of action can clearly be expected from physical studies of cloned and expressed vitamin D receptor and its subdomains, elucidation of the transcription factors in vitamin D-modulated transcription of target genes, elucidation of the role of phosphorylation in the transcription process, and the identification of important genes that are regulated in the specific target tissues responsive to vitamin D. Vitamin D 37-46 vitamin D receptor Homo sapiens 137-155 7491109-4 1995 Initial screening of these mutants indicated that all were significantly impaired in their ability to activate transcription from a vitamin D-responsive reporter construct when expressed in transfected VDR-deficient COS-7 cells. Vitamin D 132-141 vitamin D receptor Homo sapiens 202-205 21597875-3 1995 The affinity of vitamin D analogs for vitamin D receptor relative to 125(OH)(2)-vitamin D-3 was determined with a hydroxyapatite-based competitive binding assay. Vitamin D 16-25 vitamin D receptor Homo sapiens 38-56 21597875-6 1995 Competitive binding of the vitamin D analogs to vitamin D receptor ranged from 51% to 72% that of 1,25(OH)(2)-vitamin D-3, suggesting a receptor-mediated response. Vitamin D 27-36 vitamin D receptor Homo sapiens 48-66 8577633-2 1995 The effects of the biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25 (OH)2D3), are mediated by binding to a specific intracellular vitamin D receptor, which is present in most tissues including the skin where it regulates the growth of epidermal cells. Vitamin D 47-56 vitamin D receptor Homo sapiens 151-169 7558419-5 1995 Although the antiproliferative effect of the vitamin-D sterols requires high-affinity binding to the cytoplasmic vitamin-D receptor (VDR), vitamin-D sterols have no effect on VDR mRNA levels in Caco-2 cells. Vitamin D 45-54 vitamin D receptor Homo sapiens 113-131 7558419-5 1995 Although the antiproliferative effect of the vitamin-D sterols requires high-affinity binding to the cytoplasmic vitamin-D receptor (VDR), vitamin-D sterols have no effect on VDR mRNA levels in Caco-2 cells. Vitamin D 113-122 vitamin D receptor Homo sapiens 133-136 7558419-7 1995 This suggests that VDR mRNA abundance could nevertheless be important for vitamin-D-related c-myc-independent growth control in Caco-2 cells. Vitamin D 74-83 vitamin D receptor Homo sapiens 19-22 7673427-11 1995 These data indicate that the VDR alleles are associated with differences in the vitamin D endocrine system and may have important implications in relation to the pathophysiology of osteoporosis. Vitamin D 80-89 vitamin D receptor Homo sapiens 29-32 7575575-3 1995 The T-box mutant hVDR displayed attenuated vitamin D responsive element (VDRE) binding in the presence of RXR and was severely compromised in transcriptional activation. Vitamin D 43-52 vitamin D receptor Homo sapiens 17-21 7876247-1 1995 The vitamin D receptor (VDR) heterodimerizes with retinoid X receptors (RXR) on many vitamin D-responsive promoter elements, suggesting that this complex is the active factor in vitamin D-mediated transcription. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 8579895-1 1995 The nuclear vitamin D receptor (VDR) binds the 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]hormone with high affinity and elicits its actions to regulate gene expression in target cells by binding to vitamin D-responsive elements (VDREs). Vitamin D 12-21 vitamin D receptor Homo sapiens 32-35 8579895-8 1995 Recent data reveal that after binding RXR, a subsequent target for VDR in the vitamin D signal transduction cascade is basal transcription factor IIB (TFIIB). Vitamin D 78-87 vitamin D receptor Homo sapiens 67-70 7552094-1 1995 The genomic action of calcitriol is mediated through the interaction of the calcitriol receptor (VDR) with the vitamin D response elements of the target genes. Vitamin D 111-120 vitamin D receptor Homo sapiens 97-100 7626514-1 1995 The nuclear vitamin D receptor (VDR) binds the 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) hormone with high affinity and elicits its actions to stimulate gene expression in target cells by binding to the vitamin D-responsive element (VDRE). Vitamin D 12-21 vitamin D receptor Homo sapiens 32-35 7626514-4 1995 The expressed hVDR displays strict dependence on the family of retinoid X receptors (RXRs) for binding to the vitamin D-responsive element (VDRE) in the rat osteocalcin gene. Vitamin D 110-119 vitamin D receptor Homo sapiens 14-18 7876247-1 1995 The vitamin D receptor (VDR) heterodimerizes with retinoid X receptors (RXR) on many vitamin D-responsive promoter elements, suggesting that this complex is the active factor in vitamin D-mediated transcription. Vitamin D 85-94 vitamin D receptor Homo sapiens 4-22 7876247-1 1995 The vitamin D receptor (VDR) heterodimerizes with retinoid X receptors (RXR) on many vitamin D-responsive promoter elements, suggesting that this complex is the active factor in vitamin D-mediated transcription. Vitamin D 85-94 vitamin D receptor Homo sapiens 24-27 7899080-1 1995 The vitamin D receptor mediates the signal of 1 alpha, 25-dihydroxyvitamin D3 by binding to vitamin D responsive elements in DNA as a homodimer or as a heterodimer composed of one vitamin D receptor subunit and one retinoid X receptor subunit. Vitamin D 4-13 vitamin D receptor Homo sapiens 180-198 7828346-1 1994 OBJECTIVE: Hereditary vitamin D resistant rickets (HVDRR) has been shown to be due to mutations in the gene encoding the vitamin D receptor (VDR). Vitamin D 22-31 vitamin D receptor Homo sapiens 121-139 7986828-1 1994 The vitamin D receptor (VDR) is a nuclear transcription factor which binds to the vitamin D response element (VDRE) of the human osteocalcin gene and regulates its expression. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 7626415-1 1995 The basic features on the vitamin D endocrine system, synthesis of the main metabolite 1,25-dihydroxyvitamin D3 (1,25) and its genomic action mediated via the vitamin D receptor (VDR), are reviewed. Vitamin D 26-35 vitamin D receptor Homo sapiens 159-177 7626415-1 1995 The basic features on the vitamin D endocrine system, synthesis of the main metabolite 1,25-dihydroxyvitamin D3 (1,25) and its genomic action mediated via the vitamin D receptor (VDR), are reviewed. Vitamin D 26-35 vitamin D receptor Homo sapiens 179-182 7626415-4 1995 Then, the basis of the systemic theory of vitamin D action on teeth (clinical and experimental data and the dissimilar distribution of VDR and of potential vitamin D-dependent proteins in dental cells) are exposed. Vitamin D 42-51 vitamin D receptor Homo sapiens 135-138 7872065-0 1994 Activation of the human osteocalcin gene by 24R,25-dihydroxyvitamin D3 occurs through the vitamin D receptor and the vitamin D-responsive element. Vitamin D 60-69 vitamin D receptor Homo sapiens 90-108 7828346-1 1994 OBJECTIVE: Hereditary vitamin D resistant rickets (HVDRR) has been shown to be due to mutations in the gene encoding the vitamin D receptor (VDR). Vitamin D 22-31 vitamin D receptor Homo sapiens 52-55 7917316-1 1994 An expanded role for vitamin D (1 alpha,25-(OH)2D3) in mammalian systems has been suggested by recent evidence that its receptor (vitamin D receptor [VDR]) is present not only in classical target organs, but in a variety of normal tissues and organs, tumor tissues, and cancer cell lines. Vitamin D 21-30 vitamin D receptor Homo sapiens 130-148 7917316-1 1994 An expanded role for vitamin D (1 alpha,25-(OH)2D3) in mammalian systems has been suggested by recent evidence that its receptor (vitamin D receptor [VDR]) is present not only in classical target organs, but in a variety of normal tissues and organs, tumor tissues, and cancer cell lines. Vitamin D 21-30 vitamin D receptor Homo sapiens 150-153 8089197-4 1994 Formation of both complexes is Vitamin D dependent and they contain the Vitamin D receptor as well as an RXR related protein. Vitamin D 31-40 vitamin D receptor Homo sapiens 72-90 8076631-1 1994 The binding of transcription factor AP-1 and vitamin D receptor (VDR) to the composite AP-1 plus vitamin-D-responsive promoter region (AP-1 + VDRE) of the human osteocalcin gene was characterized in osteocalcin-producing (MG-63) and non-producing (U2-Os, SaOs-2) human osteosarcoma cell lines. Vitamin D 97-106 vitamin D receptor Homo sapiens 45-63 8076631-1 1994 The binding of transcription factor AP-1 and vitamin D receptor (VDR) to the composite AP-1 plus vitamin-D-responsive promoter region (AP-1 + VDRE) of the human osteocalcin gene was characterized in osteocalcin-producing (MG-63) and non-producing (U2-Os, SaOs-2) human osteosarcoma cell lines. Vitamin D 97-106 vitamin D receptor Homo sapiens 65-68 8089197-8 1994 Our findings suggest variations in protein/protein and protein/DNA interactions of the VDR and RXR related complexes V1 and V2 at the osteocalcin Vitamin D responsive element that reflect unique properties of the osteosarcoma and normal diploid osteoblast phenotype. Vitamin D 146-155 vitamin D receptor Homo sapiens 87-90 8015545-4 1994 However, we have previously shown that a closely related, but distinct, element (AGTTCA; essentially the mouse osteopontin [Spp-1] vitamin D response element) acts as a high affinity target for purified hVDR in the absence of RXR. Vitamin D 131-140 vitamin D receptor Homo sapiens 203-207 8034312-1 1994 The recently described retinoid X receptors (RXRs) respond to the novel retinoid 9-cis-retinoic acid and also serve as heterodimeric partners for the vitamin D, thyroid hormone, and retinoic acid receptors (VDR, TR, and RAR, respectively). Vitamin D 150-159 vitamin D receptor Homo sapiens 207-210 8160797-8 1994 In the human kidney, the VDR is present in cells where vitamin D-inducible proteins are found; conversely it is absent from cells where vitamin D-dependent proteins are not present. Vitamin D 55-64 vitamin D receptor Homo sapiens 25-28 8160797-8 1994 In the human kidney, the VDR is present in cells where vitamin D-inducible proteins are found; conversely it is absent from cells where vitamin D-dependent proteins are not present. Vitamin D 136-145 vitamin D receptor Homo sapiens 25-28 8015545-7 1994 We find that the purified receptor selects a heptameric sequence resembling a half-site of the osteopontin vitamin D response element, consistent with osteopontin-like sequences acting as high affinity targets for hVDR in the absence of RXR. Vitamin D 107-116 vitamin D receptor Homo sapiens 214-218 8170472-1 1994 The human vitamin D receptor (hVDR) requires another nuclear protein(s), designated receptor auxiliary factor (RAF), for optimal binding to the vitamin D-responsive element (VDRE). Vitamin D 10-19 vitamin D receptor Homo sapiens 30-34 8177979-11 1994 Vitamin D-regulated factors that are involved in vitamin D-dependent active Ca transport and are present in both renal DT and intestinal epithelial cells include VDR, CaBP-D9k/28k and the PMCA. Vitamin D 0-9 vitamin D receptor Homo sapiens 162-165 8106467-3 1994 When an expression vector for the vitamin D receptor (VDR) (pSVL-VDR) was introduced together with the reporter plasmid, there was a significant ligand-dependent amplification of the vitamin D-dependent inhibition. Vitamin D 34-43 vitamin D receptor Homo sapiens 54-57 8106467-3 1994 When an expression vector for the vitamin D receptor (VDR) (pSVL-VDR) was introduced together with the reporter plasmid, there was a significant ligand-dependent amplification of the vitamin D-dependent inhibition. Vitamin D 34-43 vitamin D receptor Homo sapiens 65-68 8106467-8 1994 Both the SV40 promoter and a conventional vitamin D response element linked to a truncated SV40 promoter were activated by the liganded vitamin D receptor, whereas the Rous sarcoma virus promoter was unaffected. Vitamin D 42-51 vitamin D receptor Homo sapiens 136-154 8267583-4 1993 Moreover, since rat liver nuclear extract contains retinoid X receptors and possibly other auxiliary factors capable of forming heterodimers with hVDR that in turn associate with vitamin D responsive elements, we hypothesize that like DNA binding, 1,25(OH)2D3 binding to hVDR requires the cooperation of a co-receptor or some uncharacterized receptor activating/stabilizing factor. Vitamin D 179-188 vitamin D receptor Homo sapiens 146-150 1337119-5 1992 VDR complexes recognize vitamin D responsive element on DNA, two tandemly repeated hexanucleotide sequences separated by three base pairs. Vitamin D 24-33 vitamin D receptor Homo sapiens 0-3 8394351-10 1993 In combination with all-trans-retinoic acid, however, vitamin D enhances VDR-RAR heterodimer-mediated gene expression. Vitamin D 54-63 vitamin D receptor Homo sapiens 73-76 8392065-10 1993 Mutation of serine 51 to glycine (S51G) or to aspartic acid (S51D), as well as altering the basic residues flanking serine 51, abolished the interaction of hVDR with the vitamin D-responsive element (VDRE) as monitored by gel mobility shift analysis. Vitamin D 170-179 vitamin D receptor Homo sapiens 156-160 8392085-1 1993 We have identified and characterized two mutations in the hormone binding domain of the vitamin D receptor (VDR) in patients with hereditary vitamin D-resistant rickets. Vitamin D 88-97 vitamin D receptor Homo sapiens 108-111 8395017-1 1993 The vitamin D receptor (VDR) binds the vitamin D-responsive element (VDRE) as a heterodimer with an unidentified receptor auxiliary factor (RAF) present in mammalian cell nuclear extracts. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 8382345-3 1993 We have identified two classes of vitamin D response elements that are activated either by the vitamin D receptor (VDR) alone or by heterodimers of VDR and the retinoid-X receptor-alpha (RXR-alpha). Vitamin D 34-43 vitamin D receptor Homo sapiens 95-113 8382345-3 1993 We have identified two classes of vitamin D response elements that are activated either by the vitamin D receptor (VDR) alone or by heterodimers of VDR and the retinoid-X receptor-alpha (RXR-alpha). Vitamin D 34-43 vitamin D receptor Homo sapiens 115-118 8382345-3 1993 We have identified two classes of vitamin D response elements that are activated either by the vitamin D receptor (VDR) alone or by heterodimers of VDR and the retinoid-X receptor-alpha (RXR-alpha). Vitamin D 34-43 vitamin D receptor Homo sapiens 148-151 8382345-4 1993 The motif GGGTGA arranged as a direct repeat with a spacing of six nucleotides or as a palindrome without spacing, or as an inverted palindrome with a 12-nucleotide spacing, confers vitamin D inducibility mediated by VDR alone. Vitamin D 182-191 vitamin D receptor Homo sapiens 217-220 1336301-1 1992 We have localized the locus for the vitamin D receptor (VDR) responsible for hypocalcemic vitamin D-resistant rickets (HVDRR), close to the pseudovitamin D-deficient rickets (PDDR) locus, another disorder related to impaired vitamin D metabolism. Vitamin D 36-45 vitamin D receptor Homo sapiens 56-59 1336301-1 1992 We have localized the locus for the vitamin D receptor (VDR) responsible for hypocalcemic vitamin D-resistant rickets (HVDRR), close to the pseudovitamin D-deficient rickets (PDDR) locus, another disorder related to impaired vitamin D metabolism. Vitamin D 90-99 vitamin D receptor Homo sapiens 36-54 1336301-1 1992 We have localized the locus for the vitamin D receptor (VDR) responsible for hypocalcemic vitamin D-resistant rickets (HVDRR), close to the pseudovitamin D-deficient rickets (PDDR) locus, another disorder related to impaired vitamin D metabolism. Vitamin D 90-99 vitamin D receptor Homo sapiens 56-59 1337987-10 1992 Taken together, the study demonstrates a vitamin D-induced inhibitory effect of LPS-driven monokine production, which is most likely a vitamin D-receptor mediated phenomenon exerted at a post-transcriptional, presecretory level. Vitamin D 41-50 vitamin D receptor Homo sapiens 135-153 1312760-1 1992 The mechanisms by which glucocorticoids (GC) inhibit some actions of vitamin D [1,25-(OH)2D3] are not well understood, but there is growing evidence that GC alter vitamin D receptor (VDR) number. Vitamin D 69-78 vitamin D receptor Homo sapiens 183-186 1353882-2 1992 Its synthesis is induced by calcitriol, the active hormonal form of vitamin D, through the vitamin D receptor and a specific vitamin D-responsive element in the osteocalcin gene promoter. Vitamin D 68-77 vitamin D receptor Homo sapiens 91-109 1665675-5 1991 Future studies with regard to the mechanism of vitamin D action must be aimed at gaining additional insight into the nature of VDREs, acquiring further detail about the interaction of the VDR with these elements, identifying factors that facilitate VDR DNA binding, and determining the biochemical mechanism by which the binding of receptor to these elements leads to modulation of common transcriptional machinery. Vitamin D 47-56 vitamin D receptor Homo sapiens 127-130 1660470-3 1991 In this report, we examine the nature of specific VDR DNA binding utilizing the vitamin D-responsive element derived from the human osteocalcin promoter. Vitamin D 80-89 vitamin D receptor Homo sapiens 50-53 1655763-6 1991 Recombinant hVDR generated a specific protein-DNA complex with a duplex oligomer containing a vitamin D-responsive element (VDRE) in gel mobility shift assays. Vitamin D 94-103 vitamin D receptor Homo sapiens 12-16 1665675-5 1991 Future studies with regard to the mechanism of vitamin D action must be aimed at gaining additional insight into the nature of VDREs, acquiring further detail about the interaction of the VDR with these elements, identifying factors that facilitate VDR DNA binding, and determining the biochemical mechanism by which the binding of receptor to these elements leads to modulation of common transcriptional machinery. Vitamin D 47-56 vitamin D receptor Homo sapiens 188-191 33803480-4 2021 Both the vitamin D active metabolite and synthetic analog regulated the growth of not only estrogen receptor-positive cells (T47D and MCF-7, in vitro and in vivo), but also hormone-independent cancer cells such as SKBR-3 (HER-2-positive) and MDA-MB-231 (triple-negative), despite their relatively low VDR expression. Vitamin D 9-18 vitamin D receptor Homo sapiens 301-304 1652893-1 1991 Vitamin D-dependent rickets type II is a hereditary disease resulting from a defective vitamin D receptor. Vitamin D 0-9 vitamin D receptor Homo sapiens 87-105 2174892-6 1990 Binding, however, required the presence of a mammalian cell protein factor that also enhances vitamin D response element interaction by mammalian cell-derived VDR. Vitamin D 94-103 vitamin D receptor Homo sapiens 159-162 2171704-3 1990 Since most of the actions of vitamin D are mediated by its receptors (VDR), abnormalities of VDR have been postulated in XLH. Vitamin D 29-38 vitamin D receptor Homo sapiens 70-73 2171704-3 1990 Since most of the actions of vitamin D are mediated by its receptors (VDR), abnormalities of VDR have been postulated in XLH. Vitamin D 29-38 vitamin D receptor Homo sapiens 93-96 2171704-9 1990 These results indicate that a decreased concentration of VDR secondary to persistent hypophosphatemia is one of the causes of vitamin D resistance in XLH. Vitamin D 126-135 vitamin D receptor Homo sapiens 57-60 2168795-2 1990 The results showed that vitamin D deficiency rickets (VDR) were still present in some infants when vitamin D was sufficient, because of deficiency of 1,25-dihydroxyvitamin D (1,25-(OH)2D3). Vitamin D 24-33 vitamin D receptor Homo sapiens 54-57 2168795-2 1990 The results showed that vitamin D deficiency rickets (VDR) were still present in some infants when vitamin D was sufficient, because of deficiency of 1,25-dihydroxyvitamin D (1,25-(OH)2D3). Vitamin D 99-108 vitamin D receptor Homo sapiens 54-57 33801744-1 2021 Vitamin D deficiency has adverse effects on renal allograft outcomes, and polymorphisms of genes encoding vitamin D-binding protein (VDBP) and vitamin D receptor (VDR) are defined to play a role in these conditions. Vitamin D 0-9 vitamin D receptor Homo sapiens 143-161 33801744-1 2021 Vitamin D deficiency has adverse effects on renal allograft outcomes, and polymorphisms of genes encoding vitamin D-binding protein (VDBP) and vitamin D receptor (VDR) are defined to play a role in these conditions. Vitamin D 0-9 vitamin D receptor Homo sapiens 163-166 1846564-3 1991 We used human osteosarcoma cells (MG-63) and measured hVDR and GR mRNA levels after androgen, estrogen, glucocorticoid, progesterone, thyroid hormone, vitamin A and vitamin D treatments. Vitamin D 165-174 vitamin D receptor Homo sapiens 54-65 33761087-4 2021 In this study, we evaluated the mRNA expression of VDR and PDIA3 involved in vitamin D signaling in cell lines representing different stages of PCa (PNT2, P4E6, LNCaP, DU145 and PC3). Vitamin D 77-86 vitamin D receptor Homo sapiens 51-54 33806559-3 2021 VDR gene polymorphism can influence individual predisposition to OP and response to vitamin D supplementation. Vitamin D 84-93 vitamin D receptor Homo sapiens 0-3 34727512-2 2022 Vitamin D replete (VDR) status may prevent significant postparathyroidectomy hypocalcaemia; however, reports from previous studies are conflicting. Vitamin D 0-9 vitamin D receptor Homo sapiens 19-22 12694466-3 2003 Vitamin D acts via vitamin D receptor (VDR), and an association of genetic polymorphisms of the VDR gene has been reported. Vitamin D 0-9 vitamin D receptor Homo sapiens 19-37 12694466-3 2003 Vitamin D acts via vitamin D receptor (VDR), and an association of genetic polymorphisms of the VDR gene has been reported. Vitamin D 0-9 vitamin D receptor Homo sapiens 39-42 12694466-3 2003 Vitamin D acts via vitamin D receptor (VDR), and an association of genetic polymorphisms of the VDR gene has been reported. Vitamin D 0-9 vitamin D receptor Homo sapiens 96-99 34864062-9 2022 Moreover, it has been demonstrated that altered gene expression of VDR and 1,25D3-membrane-associated rapid response steroid-binding (1,25D3-MARRS) receptor influences the role of vitamin D within neurons and allows them to be more prone to degeneration. Vitamin D 180-189 vitamin D receptor Homo sapiens 67-81 34727512-8 2022 Following vitamin D therapy there were 148 (77.9%) VDR and 42 (22.1%) VDNR. Vitamin D 10-19 vitamin D receptor Homo sapiens 51-54 33813457-1 2021 OBJECTIVE: The aim: The objective of the study was to investigate the polymorphism of the vitamin D receptor (VDR) BsmI gene in children with growth hormone deficiency and the level of their vitamin D supply. Vitamin D 90-99 vitamin D receptor Homo sapiens 110-113 34886758-7 2021 The immune function of vitamin D is explained in part by the presence of its receptor (VDR) and its activating enzyme 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1) in immune cells. Vitamin D 23-32 vitamin D receptor Homo sapiens 87-90 34977255-1 2021 Vitamin D is an important hormone involved in various physiologic processes, and its activity is linked to binding with vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 120-138 34977255-1 2021 Vitamin D is an important hormone involved in various physiologic processes, and its activity is linked to binding with vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 140-143 34977255-2 2021 Genetic polymorphisms in the VDR gene could modulate the expression or function of the receptor and, consequently, alter the effects of vitamin D. Vitamin D 136-145 vitamin D receptor Homo sapiens 29-32 34977255-3 2021 Variants in VDR gene have been associated with susceptibility to many illnesses sensitive to vitamin D administration and to autoimmune disorders, but no data are available regarding autoimmune connective tissue diseases in Italian population. Vitamin D 93-102 vitamin D receptor Homo sapiens 12-15 34919268-3 2022 This study aimed to evaluate the association between the VDR gene polymorphism at Fok I, Taq I, Bsm I, and Apa I genotypes and the prognosis of COVID-19 in respect to vitamin D deficiency. Vitamin D 167-176 vitamin D receptor Homo sapiens 57-60 34917354-2 2022 Vitamin D receptor (VDR) can play a tumor suppressor role by helping the precise function of vitamin D in cells such as modulation TGF-beta signaling pathway. Vitamin D 93-102 vitamin D receptor Homo sapiens 0-18 34743945-4 2021 Vitamin D interaction with the vitamin D receptor (VDR), which has transcriptional imparts and is displayed on a variety of cell types, including those of the immune system, appears to be accountable for the immune-modulating effects. Vitamin D 0-9 vitamin D receptor Homo sapiens 31-49 34743945-4 2021 Vitamin D interaction with the vitamin D receptor (VDR), which has transcriptional imparts and is displayed on a variety of cell types, including those of the immune system, appears to be accountable for the immune-modulating effects. Vitamin D 0-9 vitamin D receptor Homo sapiens 51-54 34710370-7 2021 In silico results identified the presence of vitamin D response element (VDRE) sequence on PRMT1 suggesting that VDR could regulate PRMT1 gene expression. Vitamin D 45-54 vitamin D receptor Homo sapiens 113-116 34917354-2 2022 Vitamin D receptor (VDR) can play a tumor suppressor role by helping the precise function of vitamin D in cells such as modulation TGF-beta signaling pathway. Vitamin D 93-102 vitamin D receptor Homo sapiens 20-23 34950829-3 2021 The expression of the vitamin D receptor by different cell types in the lung and the fact that those cells respond to vitamin D or can locally produce vitamin D indicate that the lung represents a target for vitamin D actions. Vitamin D 118-127 vitamin D receptor Homo sapiens 22-40 34725922-2 2021 However, whether vitamin D deficiency would result in some impacts on the vitamin D binding receptor (VDR) remains to be characterized in AD. Vitamin D 17-26 vitamin D receptor Homo sapiens 74-100 34725922-2 2021 However, whether vitamin D deficiency would result in some impacts on the vitamin D binding receptor (VDR) remains to be characterized in AD. Vitamin D 17-26 vitamin D receptor Homo sapiens 102-105 34925313-3 2021 Ten SNPs in vitamin D metabolic pathway genes (CYP2R1, CYP24A1, VDR, CYP27B1) were genotyped in 477 RA patients and 496 controls by improved multiple ligase detection reaction (iMLDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 64-67 34343413-6 2021 RESULTS: We noticed that levels of vitamin D are extensively studied in atopy by many research groups, however, polymorphisms of vitamin D receptor gene and their link with levels of vitamin D lack comprehensive data. Vitamin D 183-192 vitamin D receptor Homo sapiens 129-147 34884710-8 2021 Furthermore, the effect of vitamin D on expression of IL-33 and ST2 was VDR-dependent. Vitamin D 27-36 vitamin D receptor Homo sapiens 72-75 34944566-6 2021 The review presents the molecular genetic mechanisms of the effect of vitamin D on adipose tissue resident T lymphocytes and the characteristics of vitamin D receptor expression, and analyzes the phenotypic and functional characteristics of potentially pathogenic T lymphocytes in relation to the development of obesity and its associated complications. Vitamin D 70-79 vitamin D receptor Homo sapiens 148-166 34950829-3 2021 The expression of the vitamin D receptor by different cell types in the lung and the fact that those cells respond to vitamin D or can locally produce vitamin D indicate that the lung represents a target for vitamin D actions. Vitamin D 208-217 vitamin D receptor Homo sapiens 22-40 34732414-2 2021 Vitamin D signaling is mediated by vitamin D receptor (VDR) activated by 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) and is also important in intestinal functions, such as calcium absorption and epithelial barrier maintenance. Vitamin D 0-9 vitamin D receptor Homo sapiens 35-53 34851599-3 2021 In order to exert its functions, vitamin D has to be hydroxylated (via CYP27A1 and CYP27B1 hydroxylases), which is followed by its interaction with the vitamin D receptor (VDR) or retinoic acid-related orphan receptors alpha or gamma (RORalpha and RORgamma). Vitamin D 33-42 vitamin D receptor Homo sapiens 152-170 34851599-3 2021 In order to exert its functions, vitamin D has to be hydroxylated (via CYP27A1 and CYP27B1 hydroxylases), which is followed by its interaction with the vitamin D receptor (VDR) or retinoic acid-related orphan receptors alpha or gamma (RORalpha and RORgamma). Vitamin D 33-42 vitamin D receptor Homo sapiens 172-175 34727991-3 2021 This study will aim to investigate the possible effects of individual polymorphisms in vitamin D receptor (VDR) as well as effects of VDR haplotypes on response to vitamin D supplementation in breast cancer survivors. Vitamin D 164-173 vitamin D receptor Homo sapiens 134-137 34727991-11 2021 If responses to vitamin D supplementation could be modified by VDR SNPs, determining the distribution of VDR polymorphisms in both breast cancer survivors and healthy populations will provide a new insight into the vitamin D requirements of individuals to prevent cancer and its related mortality based on their genotypes. Vitamin D 16-25 vitamin D receptor Homo sapiens 63-66 34727991-11 2021 If responses to vitamin D supplementation could be modified by VDR SNPs, determining the distribution of VDR polymorphisms in both breast cancer survivors and healthy populations will provide a new insight into the vitamin D requirements of individuals to prevent cancer and its related mortality based on their genotypes. Vitamin D 16-25 vitamin D receptor Homo sapiens 105-108 34727991-11 2021 If responses to vitamin D supplementation could be modified by VDR SNPs, determining the distribution of VDR polymorphisms in both breast cancer survivors and healthy populations will provide a new insight into the vitamin D requirements of individuals to prevent cancer and its related mortality based on their genotypes. Vitamin D 215-224 vitamin D receptor Homo sapiens 105-108 34732414-2 2021 Vitamin D signaling is mediated by vitamin D receptor (VDR) activated by 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) and is also important in intestinal functions, such as calcium absorption and epithelial barrier maintenance. Vitamin D 0-9 vitamin D receptor Homo sapiens 55-58 34502510-3 2021 The present study was aimed at investigating-through high-throughput gene and protein analysis-the response of human disc cells to vitamin D, depending on the VDR FokI variants. Vitamin D 131-140 vitamin D receptor Homo sapiens 159-162 34486787-4 2021 Here, it is aimed to investigate the effect of vitamin D-related polymorphisms (VDBP and VDR) and cholesterol-related variants of ApoE on Turkish MS patients. Vitamin D 47-56 vitamin D receptor Homo sapiens 89-92 34835929-4 2021 RECENT FINDINGS: various cells (i.e., neurons, astrocytes, and microglia) within the central nervous system (CNS) express vitamin D receptors (VDR). Vitamin D 122-131 vitamin D receptor Homo sapiens 143-146 34304574-1 2021 BACKGROUND: the biological activity of vitamin D depends on the activity of its receptor or VDR. Vitamin D 39-48 vitamin D receptor Homo sapiens 92-95 34304574-4 2021 Secondly, it was to verify if the status of some metabolic factors (oxidative stress, inflammation, lipid profile, and glycemia) in the serum, and gender-adjusted vitamin D levels are independent factors with an influence on the VDR methylation profile. Vitamin D 163-172 vitamin D receptor Homo sapiens 229-232 34304574-9 2021 CONCLUSION: we conclude that the methylation profile of the VDR gene is not influenced by the different BsmI polymorphism genotypes, and that serum vitamin D and serum markers of oxidative stress and inflammation can modulate this profile. Vitamin D 148-157 vitamin D receptor Homo sapiens 60-63 34562448-2 2021 This antiviral role of vitamin D is widely attributed to Vitamin D Receptor (VDR)/Retinoid X Receptor (RXR)-mediated regulation of host immunomodulatory genes through Vitamin D Response Elements (VDREs) in their promoters. Vitamin D 23-32 vitamin D receptor Homo sapiens 57-75 34562448-2 2021 This antiviral role of vitamin D is widely attributed to Vitamin D Receptor (VDR)/Retinoid X Receptor (RXR)-mediated regulation of host immunomodulatory genes through Vitamin D Response Elements (VDREs) in their promoters. Vitamin D 23-32 vitamin D receptor Homo sapiens 77-80 34562448-2 2021 This antiviral role of vitamin D is widely attributed to Vitamin D Receptor (VDR)/Retinoid X Receptor (RXR)-mediated regulation of host immunomodulatory genes through Vitamin D Response Elements (VDREs) in their promoters. Vitamin D 167-176 vitamin D receptor Homo sapiens 57-75 34562448-2 2021 This antiviral role of vitamin D is widely attributed to Vitamin D Receptor (VDR)/Retinoid X Receptor (RXR)-mediated regulation of host immunomodulatory genes through Vitamin D Response Elements (VDREs) in their promoters. Vitamin D 167-176 vitamin D receptor Homo sapiens 77-80 34562448-11 2021 Our findings (a) identify VDR as a novel regulator of HBV-core promoter activity, (b) explain at least in part the correlation of vitamin D levels to HBV activity in clinical studies, (c) have implications on the potential use of vitamin D along with anti-HBV therapies, and (d) lay the groundwork for studies on vitamin D-mediated regulation of viruses through VDREs in virus promoters. Vitamin D 313-322 vitamin D receptor Homo sapiens 26-29 34578994-2 2021 This study aimed to assess a relationship between the VDR genotypes, plasma concentrations of vitamin D metabolites, and the occurrence of cardiovascular and metabolic disorders. Vitamin D 94-103 vitamin D receptor Homo sapiens 54-57 34578986-9 2021 Variations in GC, CYP2R1, VDR, and CYP24A1 genes were reported most frequently, whereby especially SNPs in the GC (rs2282679, rs4588, rs1155563, rs7041) and CYP2R1 genes (rs10741657, rs10766197, rs2060793) were confirmed to be associated with vitamin D level in more than 50% of the respective studies. Vitamin D 243-252 vitamin D receptor Homo sapiens 26-29 34617343-2 2021 It has also been reported that vitamin D deficiency may play a role in this, possibly because of the multi-gene regulatory function of the vitamin D receptor. Vitamin D 31-40 vitamin D receptor Homo sapiens 139-157 34551710-11 2021 VDR genotype modified the association between vitamin D status and the following PMSx: increased appetite (interaction p = 0.027), fatigue (interaction p = 0.016), and nausea (interaction p = 0.039). Vitamin D 46-55 vitamin D receptor Homo sapiens 0-3 34584434-2 2021 Therefore, the relationship between the pathogenesis of type 1 diabetes and the genetic variants of Vitamin D receptor, which is involved in the activity of Vitamin D, was studied extensively in different populations. Vitamin D 157-166 vitamin D receptor Homo sapiens 100-118 34365149-9 2021 NDEVs results will need to be validated in ampler cohort but we can speculate that, if at neuronal level the amounts of Vitamin D and of VDR are comparable, than the bioavailability of vitamin D and the efficacy of the vitamin D/VDR axis is differentially modulated in PD by VDR SNPs. Vitamin D 120-129 vitamin D receptor Homo sapiens 275-278 34365149-9 2021 NDEVs results will need to be validated in ampler cohort but we can speculate that, if at neuronal level the amounts of Vitamin D and of VDR are comparable, than the bioavailability of vitamin D and the efficacy of the vitamin D/VDR axis is differentially modulated in PD by VDR SNPs. Vitamin D 185-194 vitamin D receptor Homo sapiens 275-278 34463798-1 2022 OBJECTIVES: To explore the association between genetic polymorphisms in vitamin D receptor (VDR), vitamin D serum levels, and variability in dental age. Vitamin D 98-107 vitamin D receptor Homo sapiens 72-90 34261187-2 2021 Vitamin D through binding to vitamin D receptor (VDR) exerts its function and affects gene transcription in target tissues. Vitamin D 0-9 vitamin D receptor Homo sapiens 29-47 34261187-2 2021 Vitamin D through binding to vitamin D receptor (VDR) exerts its function and affects gene transcription in target tissues. Vitamin D 0-9 vitamin D receptor Homo sapiens 49-52 34578782-12 2021 The children in our study had a favorable VDR gene genotype, however the effect of VDR gene promoter activity might not be revealed due to very low vitamin D and calcium intake to stimulate intestinal calcium absorption which in turn affects HAZ. Vitamin D 148-157 vitamin D receptor Homo sapiens 83-86 34621381-0 2021 25-OH Vitamin D blood serum linkage with VDR gene polymorphism (rs2228570) in thyroid pathology patients in the West-Ukrainian population. Vitamin D 6-15 vitamin D receptor Homo sapiens 41-44 34408754-9 2021 Finally, we identified a vitamin D response element (VDRE) in the il22 promoter and demonstrate that 1,25(OH)2D3-VDR directly inhibits IL-22 production via this repressive VDRE. Vitamin D 25-34 vitamin D receptor Homo sapiens 113-116 34298730-6 2021 We provide evidence from both clinical studies as well as molecular studies of metabolic targets, including vitamin D receptor and activating enzymes exerting an effect on PTC tissue, which indicate that vitamin D may play a significant prognostic role in PTC. Vitamin D 204-213 vitamin D receptor Homo sapiens 108-126 34421816-1 2021 Background: It has been demonstrated that vitamin D receptor (VDR), a key gene in the metabolism of vitamin D (VD), may affect the development of Non-alcoholic fatty liver disease (NAFLD) by regulating VD level and its biological effects. Vitamin D 100-109 vitamin D receptor Homo sapiens 42-60 34421816-1 2021 Background: It has been demonstrated that vitamin D receptor (VDR), a key gene in the metabolism of vitamin D (VD), may affect the development of Non-alcoholic fatty liver disease (NAFLD) by regulating VD level and its biological effects. Vitamin D 100-109 vitamin D receptor Homo sapiens 62-65 34621381-4 2021 The study"s objective was to investigate the association between VDR gene polymorphism (rs2228570) with blood serum levels of 25-OH vitamin D in patients with thyroid pathology from western Ukraine. Vitamin D 132-141 vitamin D receptor Homo sapiens 65-68 34166428-3 2021 Vitamin D regulates immune responses through the vitamin D receptor on CD4 cells. Vitamin D 0-9 vitamin D receptor Homo sapiens 49-67 34206371-3 2021 The nuclear vitamin D receptor (VDR) is crucial for the phenotypic effects of vitamin D hydroxyderivatives. Vitamin D 78-87 vitamin D receptor Homo sapiens 12-30 34206371-3 2021 The nuclear vitamin D receptor (VDR) is crucial for the phenotypic effects of vitamin D hydroxyderivatives. Vitamin D 78-87 vitamin D receptor Homo sapiens 32-35 34206371-8 2021 These results indicate that expression of VDR is important for the inhibition of melanoma growth induced by activated forms of vitamin D. Vitamin D 127-136 vitamin D receptor Homo sapiens 42-45 34208603-4 2021 Therefore, this study aimed to evaluate the association of VDR polymorphisms with susceptibility to psoriasis, effectiveness of NB-UVB phototherapy and concentration of proinflammatory cytokines and vitamin D amongst the Polish population. Vitamin D 199-208 vitamin D receptor Homo sapiens 59-62 34208589-8 2021 It should also be underlined that many types of cancer cells present alterations in vitamin D metabolism and action as a result of Vitamin D Receptor (VDR) and CYP27B1 expression dysregulation. Vitamin D 84-93 vitamin D receptor Homo sapiens 131-149 34208589-8 2021 It should also be underlined that many types of cancer cells present alterations in vitamin D metabolism and action as a result of Vitamin D Receptor (VDR) and CYP27B1 expression dysregulation. Vitamin D 84-93 vitamin D receptor Homo sapiens 151-154 34072725-6 2021 Recent advances in demonstrating the important functions of vitamin D/vitamin D receptor (VDR) signaling in the regulation of stromal reprogramming, the microbiome, and immune response and the emergence of checkpoint immunotherapy provide opportunities for using vitamin D or its analogues as an adjunct for pancreatic cancer intervention. Vitamin D 263-272 vitamin D receptor Homo sapiens 90-93 34245553-5 2021 METHODS: In this study, four common VDR polymorphisms and associations with vitamin D deficiency in the Turkish Cypriot population between ages 18-40 and working in office conditions was studied by PCR- RFLP analysis. Vitamin D 76-85 vitamin D receptor Homo sapiens 36-39 34245553-7 2021 CONCLUSION: Together with the effect of rs2228570 C>T variant in the VDR gene, it is thought that the lifestyle changes in the Turkish Cypriot population might have caused the increased frequency of vitamin D deficiency in the young professionals. Vitamin D 199-208 vitamin D receptor Homo sapiens 69-72 34093587-1 2021 The active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), mediates its immunomodulatory effects by binding to the vitamin D receptor (VDR). Vitamin D 19-28 vitamin D receptor Homo sapiens 126-144 34113565-4 2021 Vitamin D elucidates its biological responses by binding the vitamin D receptor; thus, promoting skeletal mineralization, and maintain calcium homeostasis. Vitamin D 0-9 vitamin D receptor Homo sapiens 61-79 34093587-1 2021 The active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), mediates its immunomodulatory effects by binding to the vitamin D receptor (VDR). Vitamin D 19-28 vitamin D receptor Homo sapiens 146-149 34066482-3 2021 Moreover, the active form of vitamin D, i.e., 1,25-dihydroxyvitamin D, exerts various effects via its interaction with the vitamin D receptor on the innate and adaptive immune system, which could be relevant in the onset of tumors. Vitamin D 29-38 vitamin D receptor Homo sapiens 123-141 34069442-5 2021 Activation of VDR with vitamin D (VitD), either calcitriol or its synthetic analog EB1089, sensitized MCF-7-derived, antiestrogen-resistant LCC9 human breast cancer cells to TAM, and attenuated increased UPR and pro-survival autophagy. Vitamin D 23-32 vitamin D receptor Homo sapiens 14-17 34066482-6 2021 Changes in the vitamin D receptor often contribute to the occurrence and progress of deficiencies, which can be overcome by supplementation with vitamin D or analogues. Vitamin D 145-154 vitamin D receptor Homo sapiens 15-33 34251342-2 2021 It has been established that vitamin D deficiency is one of DKD risk factors, which may be related to vitamin D receptor (VDR) polymorphisms. Vitamin D 29-38 vitamin D receptor Homo sapiens 102-120 34091780-3 2021 This ligand (vitamin D) and receptors (VDR-RXR) complex together triggers downstream DNA damage response in the cell and thus counters cancer in blood. Vitamin D 13-22 vitamin D receptor Homo sapiens 39-42 34091780-10 2021 Also, the mRNA expression of VDR showed a positive and non-significant relationship with vitamin D levels and RXR expression (p > 0.05). Vitamin D 89-98 vitamin D receptor Homo sapiens 29-32 34251342-2 2021 It has been established that vitamin D deficiency is one of DKD risk factors, which may be related to vitamin D receptor (VDR) polymorphisms. Vitamin D 29-38 vitamin D receptor Homo sapiens 122-125 34937516-1 2021 OBJECTIVE: To study the relationship between vitamin D deficiency, VDR gene polymorphism rs10735810 (A > G), and a missed abortion in the first trimester of gestation; to determine the predictors of its risk. Vitamin D 45-54 vitamin D receptor Homo sapiens 67-70 34139712-0 2021 Association of Vitamin D Receptor Gene Polymorphisms with Serum Vitamin D Levels in a Greek Rural Population (Velestino Study). Vitamin D 64-73 vitamin D receptor Homo sapiens 15-33 34139712-1 2021 BACKGROUND/AIM: An alarming increase in vitamin D deficiency even in sunny regions highlights the need for a better understanding of the genetic background of the vitamin D endocrine system and the molecular mechanisms of gene polymorphisms of the vitamin D receptor (VDR). Vitamin D 40-49 vitamin D receptor Homo sapiens 248-266 34139712-1 2021 BACKGROUND/AIM: An alarming increase in vitamin D deficiency even in sunny regions highlights the need for a better understanding of the genetic background of the vitamin D endocrine system and the molecular mechanisms of gene polymorphisms of the vitamin D receptor (VDR). Vitamin D 40-49 vitamin D receptor Homo sapiens 268-271 34139712-6 2021 CONCLUSIONS: Our findings reveal a cumulative effect of specific VDR gene polymorphisms that may regulate vitamin D concentrations explaining, in part, the paradox of vitamin D deficiency in sunny regions, with important implications for precision medicine. Vitamin D 106-115 vitamin D receptor Homo sapiens 65-68 34139712-6 2021 CONCLUSIONS: Our findings reveal a cumulative effect of specific VDR gene polymorphisms that may regulate vitamin D concentrations explaining, in part, the paradox of vitamin D deficiency in sunny regions, with important implications for precision medicine. Vitamin D 167-176 vitamin D receptor Homo sapiens 65-68 35501225-3 2022 AIM OF THE STUDY: To evaluate the relationship between VDR gene polymorphisms FokI and BsmI with BCF and vitamin D status in a population of non-obese Mexican adults. Vitamin D 105-114 vitamin D receptor Homo sapiens 55-58 34291138-11 2021 Thus, monitoring the methylation status of specific VDR promoter region might help stratify the high-risk individuals who could potentially benefit from vitamin D dietary supplementation. Vitamin D 153-162 vitamin D receptor Homo sapiens 52-55 35595176-3 2022 The mechanisms that underpin the link between low 25(OH)D3 and sarcopenia are yet to be fully understood but several lines of evidence have highlighted the importance of both genomic and non-genomic effects of active vitamin D (1,25-dihydroxyvitamin D (1,25(OH)2D3)) and its nuclear vitamin D receptor (VDR), in skeletal muscle functioning. Vitamin D 217-226 vitamin D receptor Homo sapiens 283-301 35595176-3 2022 The mechanisms that underpin the link between low 25(OH)D3 and sarcopenia are yet to be fully understood but several lines of evidence have highlighted the importance of both genomic and non-genomic effects of active vitamin D (1,25-dihydroxyvitamin D (1,25(OH)2D3)) and its nuclear vitamin D receptor (VDR), in skeletal muscle functioning. Vitamin D 217-226 vitamin D receptor Homo sapiens 303-306 35468986-1 2022 The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D), and its analogues signal through the nuclear vitamin D receptor (VDR), a ligand-regulated transcription factor, and have been extensively investigated as anticancer agents. Vitamin D 19-28 vitamin D receptor Homo sapiens 108-126 35131190-0 2022 Vitamin D status in Dupuytren"s disease: Association with clinical status and vitamin D receptor expression. Vitamin D 0-9 vitamin D receptor Homo sapiens 78-96 35131190-11 2022 Moreover, a positive correlation was found between vitamin D levels and expression of VDR in pathologic fascia in patients undergoing fasciectomy for contracture. Vitamin D 51-60 vitamin D receptor Homo sapiens 86-89 35131190-13 2022 Expression of VDR was lower in the vitamin D deficient group. Vitamin D 35-44 vitamin D receptor Homo sapiens 14-17 35131190-15 2022 The potential role of vitamin D and its interaction with VDR and the TGF-beta1 signaling pathway in the pathogenesis of DD needs to be explored further. Vitamin D 22-31 vitamin D receptor Homo sapiens 57-60 35631254-2 2022 This has been demonstrated by studies showing that vitamin D deficiency is associated with pancreatitis and its anti-inflammatory and anti-fibrotic effects by binding with the vitamin D receptor (VDR). Vitamin D 51-60 vitamin D receptor Homo sapiens 176-194 35631254-2 2022 This has been demonstrated by studies showing that vitamin D deficiency is associated with pancreatitis and its anti-inflammatory and anti-fibrotic effects by binding with the vitamin D receptor (VDR). Vitamin D 51-60 vitamin D receptor Homo sapiens 196-199 35631254-4 2022 In this narrative review, we discuss the recent advances in our understanding of the molecular mechanisms involved in vitamin D/VDR signaling in pancreatic cells; the evidence from observational studies and clinical trials that demonstrate the connection among vitamin D, pancreatitis and pancreatitis-related complications; and the route of administration of vitamin D supplementation in clinical practice. Vitamin D 118-127 vitamin D receptor Homo sapiens 128-131 35631254-4 2022 In this narrative review, we discuss the recent advances in our understanding of the molecular mechanisms involved in vitamin D/VDR signaling in pancreatic cells; the evidence from observational studies and clinical trials that demonstrate the connection among vitamin D, pancreatitis and pancreatitis-related complications; and the route of administration of vitamin D supplementation in clinical practice. Vitamin D 261-270 vitamin D receptor Homo sapiens 128-131 35510872-1 2022 Vitamin D (VD) exerts a wide variety of actions via gene regulation mediated by the nuclear vitamin D receptor (VDR) under physiological and pathological settings. Vitamin D 0-9 vitamin D receptor Homo sapiens 92-110 35510872-1 2022 Vitamin D (VD) exerts a wide variety of actions via gene regulation mediated by the nuclear vitamin D receptor (VDR) under physiological and pathological settings. Vitamin D 0-9 vitamin D receptor Homo sapiens 112-115 35166042-4 2022 METHODS: The expression of vitamin D pathway components CYP27B1, CYP24A1, and VDR was examined in brains obtained from PD patients (Braak stage 6; n = 9) and control subjects (n = 4). Vitamin D 27-36 vitamin D receptor Homo sapiens 78-81 35401802-3 2022 However, only a limited number of studies have described the key role of vitamin D receptor (VDR) in the regulation of the functions of vitamin D and the potential effect of single nucleotide polymorphisms (SNPs) of the VDR gene. Vitamin D 136-145 vitamin D receptor Homo sapiens 73-91 35401802-3 2022 However, only a limited number of studies have described the key role of vitamin D receptor (VDR) in the regulation of the functions of vitamin D and the potential effect of single nucleotide polymorphisms (SNPs) of the VDR gene. Vitamin D 136-145 vitamin D receptor Homo sapiens 93-96 35401803-3 2022 Vitamin D and its subsequent pathway plays a key role in skin metabolism and homeostasis, with alterations in the level of vitamin D receptor (VDR) seen within pathological scars. Vitamin D 0-9 vitamin D receptor Homo sapiens 123-141 35401803-3 2022 Vitamin D and its subsequent pathway plays a key role in skin metabolism and homeostasis, with alterations in the level of vitamin D receptor (VDR) seen within pathological scars. Vitamin D 0-9 vitamin D receptor Homo sapiens 143-146 35339636-9 2022 Vitamin D inhibited mesenchymal transition in MCs and suppressed thrombospondin-1 expression via vitamin D receptor/Smad3 competition, contributing to the marked reduction in peritoneal dissemination in vivo. Vitamin D 0-9 vitamin D receptor Homo sapiens 97-115 35625724-2 2022 Through the VDR, vitamin D exerts different functions that influence immune responses, as previously shown in different preclinical models. Vitamin D 17-26 vitamin D receptor Homo sapiens 12-15 35468986-1 2022 The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D), and its analogues signal through the nuclear vitamin D receptor (VDR), a ligand-regulated transcription factor, and have been extensively investigated as anticancer agents. Vitamin D 19-28 vitamin D receptor Homo sapiens 128-131 35196255-2 2022 Key components of the vitamin D system, notably the vitamin D receptor (VDR) and the vitamin D activating enzyme (1alpha-hydroxylase), are present in a wide array of tissues, notably macrophages, dendritic cells and T lymphocytes (T cells) from the immune system. Vitamin D 22-31 vitamin D receptor Homo sapiens 52-70 35245207-2 2022 It is believed that many of the hormonal effects of vitamin D involve a 1,25-dihydroxyvitamin D3-vitamin D receptor (VDR)-mediated transcriptional mechanism involving binding to the cellular chromatin and regulating hundreds of genes in many tissues. Vitamin D 52-61 vitamin D receptor Homo sapiens 94-115 35245207-2 2022 It is believed that many of the hormonal effects of vitamin D involve a 1,25-dihydroxyvitamin D3-vitamin D receptor (VDR)-mediated transcriptional mechanism involving binding to the cellular chromatin and regulating hundreds of genes in many tissues. Vitamin D 52-61 vitamin D receptor Homo sapiens 117-120 35462022-9 2022 Vitamin D supplementation is recommended from the onset as a transcription factor to improve VDR and CAMP gene expression in leprosy patients. Vitamin D 0-9 vitamin D receptor Homo sapiens 93-96 35517045-3 2022 Vitamin D receptor (VDR) is responsible for the initiation of vitamin D signaling cascade. Vitamin D 62-71 vitamin D receptor Homo sapiens 0-18 35517045-3 2022 Vitamin D receptor (VDR) is responsible for the initiation of vitamin D signaling cascade. Vitamin D 62-71 vitamin D receptor Homo sapiens 20-23 35517045-9 2022 We believe that the reported study may support personalized approach to PD treatment, especially in terms of monitoring vitamin D level and vitamin D supplementation in patients with high risk VDR genotypes. Vitamin D 140-149 vitamin D receptor Homo sapiens 193-196 35456315-1 2022 Vitamin D analogs (VDAs) may directly inhibit the growth of normal and malignant (derived from acute lymphoblastic leukemia (ALL)) B cells, as both types of cells express vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 171-189 35456315-1 2022 Vitamin D analogs (VDAs) may directly inhibit the growth of normal and malignant (derived from acute lymphoblastic leukemia (ALL)) B cells, as both types of cells express vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 191-194 35196255-2 2022 Key components of the vitamin D system, notably the vitamin D receptor (VDR) and the vitamin D activating enzyme (1alpha-hydroxylase), are present in a wide array of tissues, notably macrophages, dendritic cells and T lymphocytes (T cells) from the immune system. Vitamin D 22-31 vitamin D receptor Homo sapiens 72-75 35318513-2 2022 Vitamin D in skin, through its receptors (VDR), regulates cell growth, differentiation, immune response and exerts both stimulatory and protective effects on melanocytes. Vitamin D 0-9 vitamin D receptor Homo sapiens 42-45 35405966-1 2022 The vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 is the natural, high-affinity ligand of the transcription factor vitamin D receptor (VDR). Vitamin D 4-13 vitamin D receptor Homo sapiens 120-138 35406694-1 2022 Vitamin D receptor (VDR) executes most of the biological functions of vitamin D. Vitamin D 70-79 vitamin D receptor Homo sapiens 0-18 35406694-1 2022 Vitamin D receptor (VDR) executes most of the biological functions of vitamin D. Vitamin D 70-79 vitamin D receptor Homo sapiens 20-23 35405966-1 2022 The vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 is the natural, high-affinity ligand of the transcription factor vitamin D receptor (VDR). Vitamin D 4-13 vitamin D receptor Homo sapiens 140-143 35318513-3 2022 The gene sequence encoding VDR has polymorphic forms such as ApaI and TaqI that may affect vitamin D actions. Vitamin D 91-100 vitamin D receptor Homo sapiens 27-30 35405966-3 2022 Thus, the epigenome and transcriptome of VDR-expressing cells is directly affected by vitamin D. Vitamin D 86-95 vitamin D receptor Homo sapiens 41-44 35308505-3 2022 The impact of vitamin D receptor (VDR) and adrenergic receptors (ADRs) genetic variants on vitamin D levels and weight loss diet outcomes was also investigated. Vitamin D 91-100 vitamin D receptor Homo sapiens 14-32 35308505-13 2022 Also, the results of the present study indicate that VDR and ADRs genetic polymorphisms seem to influence vitamin D supplementation response and obesity markers. Vitamin D 106-115 vitamin D receptor Homo sapiens 53-56 35318258-9 2022 1alpha,25(OH)2D3, the active form of vitamin D, promotes the nuclear translocation of VDR, which binds to the promoter region of Pdcd1, Tim3, and Tigit genes and inhibits their expression. Vitamin D 37-46 vitamin D receptor Homo sapiens 86-89 35001797-2 2022 Vitamin D exerts its effect through vitamin receptor (VDR), and various single nucleotide polymorphisms have been reported to affects the expression and structure of the VDR. Vitamin D 0-9 vitamin D receptor Homo sapiens 54-57 35001797-2 2022 Vitamin D exerts its effect through vitamin receptor (VDR), and various single nucleotide polymorphisms have been reported to affects the expression and structure of the VDR. Vitamin D 0-9 vitamin D receptor Homo sapiens 170-173 35001797-5 2022 Genetic variants in the VDR (FokI, TaqI, BsmI, and ApaI) were genotyped by TaqMan assay.Results: Reduced serum Vitamin D level was observed in subjects with sepsis compared to healthy controls (p <= 0.0001). Vitamin D 111-120 vitamin D receptor Homo sapiens 24-27 35204769-6 2022 This study aimed to evaluate the vitamin D contribution in the expression of VDR and CYP27B1, involved in the conversion of an inactive to an active form of vitamin D in the infected macrophages using M. tuberculosis as an infection model. Vitamin D 33-42 vitamin D receptor Homo sapiens 77-80 35267984-3 2022 This study aimed to evaluate the association of four variants in the VDR gene (rs7975232, rs1544410, rs731236, and rs2228570) with T1DM risk and vitamin D levels within a population from North Region, Brazil, as well as the influence of genomic ancestry on T1DM. Vitamin D 145-154 vitamin D receptor Homo sapiens 69-72 35204769-6 2022 This study aimed to evaluate the vitamin D contribution in the expression of VDR and CYP27B1, involved in the conversion of an inactive to an active form of vitamin D in the infected macrophages using M. tuberculosis as an infection model. Vitamin D 157-166 vitamin D receptor Homo sapiens 77-80 35204769-7 2022 The expression of LL37 and the nucleus translocation of VDR were evaluated as the readout of the response of vitamin D and determined if those processes are affected by glucose concentrations. Vitamin D 109-118 vitamin D receptor Homo sapiens 56-59 35204769-9 2022 The vitamin D-dependent induction of LL37 and the expression of VDR and CYP27B1 genes were analyzed by qPCR, and VDR translocation was analyzed in nuclear protein extracts by ELISA. Vitamin D 4-13 vitamin D receptor Homo sapiens 64-67 35204769-9 2022 The vitamin D-dependent induction of LL37 and the expression of VDR and CYP27B1 genes were analyzed by qPCR, and VDR translocation was analyzed in nuclear protein extracts by ELISA. Vitamin D 4-13 vitamin D receptor Homo sapiens 113-116 34779388-2 2022 We compared the association of BP in diabetic patients with either total vitamin D - the standard way of analyzing the vitamin D status - or free vitamin D, because only free vitamin D passes the cell membrane and interacts with the nuclear vitamin D receptor (VDR). Vitamin D 175-184 vitamin D receptor Homo sapiens 241-259 34779388-2 2022 We compared the association of BP in diabetic patients with either total vitamin D - the standard way of analyzing the vitamin D status - or free vitamin D, because only free vitamin D passes the cell membrane and interacts with the nuclear vitamin D receptor (VDR). Vitamin D 175-184 vitamin D receptor Homo sapiens 261-264 35092374-1 2022 BACKGROUND: The vitamin D receptor (VDR) is responsible for mediating the effects of vitamin D through regulation of other gene transcriptions. Vitamin D 85-94 vitamin D receptor Homo sapiens 16-34 35057541-0 2022 Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis. Vitamin D 67-76 vitamin D receptor Homo sapiens 0-18 35057541-0 2022 Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis. Vitamin D 67-76 vitamin D receptor Homo sapiens 20-23 35057541-2 2022 VDR is regulated by genetic and environmental factors and it is hypothesised that the response to vitamin D supplementation could be modulated by genetic variants in the VDR gene. Vitamin D 98-107 vitamin D receptor Homo sapiens 0-3 35057541-2 2022 VDR is regulated by genetic and environmental factors and it is hypothesised that the response to vitamin D supplementation could be modulated by genetic variants in the VDR gene. Vitamin D 98-107 vitamin D receptor Homo sapiens 170-173 35053549-0 2022 Polymorphism of VDR Gene and the Sensitivity of Human Leukemia and Lymphoma Cells to Active Forms of Vitamin D. Vitamin D 101-110 vitamin D receptor Homo sapiens 16-19 34979905-1 2022 BACKGROUND: Calcitriol (an active metabolite of vitamin D) modulates the expression of hundreds of human genes by activation of the vitamin D nuclear receptor (VDR). Vitamin D 48-57 vitamin D receptor Homo sapiens 132-158 34979905-1 2022 BACKGROUND: Calcitriol (an active metabolite of vitamin D) modulates the expression of hundreds of human genes by activation of the vitamin D nuclear receptor (VDR). Vitamin D 48-57 vitamin D receptor Homo sapiens 160-163 34935629-2 2022 It exerts its biological functions by binding to the vitamin D receptor (VDR), a transcription factor that regulates gene expression in vitamin D-target tissues such as intestine, kidney and bone. Vitamin D 136-145 vitamin D receptor Homo sapiens 53-71 34935629-2 2022 It exerts its biological functions by binding to the vitamin D receptor (VDR), a transcription factor that regulates gene expression in vitamin D-target tissues such as intestine, kidney and bone. Vitamin D 136-145 vitamin D receptor Homo sapiens 73-76 35045292-3 2022 In this study, we report the occurrence of vitamin D-specific DNA demethylation and transcriptional activation at VDR binding sites associated with the acquisition of tolerogenesis in vitro. Vitamin D 43-52 vitamin D receptor Homo sapiens 114-117 35057465-5 2022 Transcription of the human AMP genes beta-defensin 2/defensin-beta4 (HBD2/DEFB4) and cathelicidin antimicrobial peptide (CAMP) is stimulated by the VDR bound to promoter-proximal vitamin D response elements. Vitamin D 179-188 vitamin D receptor Homo sapiens 148-151 35092374-1 2022 BACKGROUND: The vitamin D receptor (VDR) is responsible for mediating the effects of vitamin D through regulation of other gene transcriptions. Vitamin D 85-94 vitamin D receptor Homo sapiens 36-39 35379049-1 2022 Objective: This study aimed to evaluate the association between vitamin D receptor (an essential component in the vitamin D signaling pathway) and serum vitamin D as well as its clinical significance in papillary thyroid cancer. Vitamin D 114-123 vitamin D receptor Homo sapiens 64-82 34995987-3 2022 RESULTS: 83% of the subjects had vitamin D deficiency further associated with VDR gene polymorphism (P 0.000). Vitamin D 33-42 vitamin D receptor Homo sapiens 78-81 35379049-1 2022 Objective: This study aimed to evaluate the association between vitamin D receptor (an essential component in the vitamin D signaling pathway) and serum vitamin D as well as its clinical significance in papillary thyroid cancer. Vitamin D 153-162 vitamin D receptor Homo sapiens 64-82 35379049-10 2022 Low vitamin D receptor expression in papillary thyroid cancer was shown to positively correlate with low serum vitamin D level and disease aggressiveness. Vitamin D 111-120 vitamin D receptor Homo sapiens 4-22 2542376-7 1989 These data provide evidence for the presence of a vitamin D microendocrine system in endothelial cells, consisting of the VDR and a 1 alpha-hydroxylase enzyme capable of producing 1,25(OH)2D3. Vitamin D 50-59 vitamin D receptor Homo sapiens 122-125 2553800-1 1989 We developed an immunohistochemical method for visualization of vitamin D (VDR) and estrogen receptors (ER) in cryostat sections, using monoclonal antibodies (MAb) to the vitamin D receptor and estrogen receptor, respectively. Vitamin D 64-73 vitamin D receptor Homo sapiens 75-78 31291127-2 2021 The activated form of vitamin D (1 alpha,25-dihydroxyvitamin D) binds to vitamin D receptor which regulates genes that control cell proliferation, differentiation and apoptosis. Vitamin D 22-31 vitamin D receptor Homo sapiens 73-91 2537329-12 1989 In summary, this vitamin D-dependent rickets, type II, kindred has a defect in the DNA-binding domain of VDR. Vitamin D 17-26 vitamin D receptor Homo sapiens 105-108 6321190-1 1984 Direct measurements of parathyroid activity are available in only small numbers of children with vitamin D deficiency rickets (VDR). Vitamin D 97-106 vitamin D receptor Homo sapiens 127-130 31446814-4 2021 The vitamin D receptor (VDR) is a crucial mediator of the pleiotropic cellular effects of vitamin D. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 33453076-2 2021 This study aimed to investigate the effect of vitamin D supplementation by maternal and offspring vitamin D receptor (VDR) genotype and GC genotype, encoding vitamin D binding protein (VDBP), in two RCTs. Vitamin D 46-55 vitamin D receptor Homo sapiens 98-116 34045549-15 2021 The finding of anti-inflammatory property by vitamin D through promotion of VDR/miR-26b-5p expression provides significant evidence that downregulation of vitamin D/VDR signaling could contribute to increased inflammatory response in preeclampsia. Vitamin D 45-54 vitamin D receptor Homo sapiens 76-79 34045549-15 2021 The finding of anti-inflammatory property by vitamin D through promotion of VDR/miR-26b-5p expression provides significant evidence that downregulation of vitamin D/VDR signaling could contribute to increased inflammatory response in preeclampsia. Vitamin D 45-54 vitamin D receptor Homo sapiens 165-168 34045549-15 2021 The finding of anti-inflammatory property by vitamin D through promotion of VDR/miR-26b-5p expression provides significant evidence that downregulation of vitamin D/VDR signaling could contribute to increased inflammatory response in preeclampsia. Vitamin D 155-164 vitamin D receptor Homo sapiens 76-79 34045549-15 2021 The finding of anti-inflammatory property by vitamin D through promotion of VDR/miR-26b-5p expression provides significant evidence that downregulation of vitamin D/VDR signaling could contribute to increased inflammatory response in preeclampsia. Vitamin D 155-164 vitamin D receptor Homo sapiens 165-168 33759562-7 2021 Collectively, these data suggest that vitamin D/VDR signaling relieves colitis development in animal models, at least in part, by suppressing HIF-1alpha expression in colonic epithelial cells. Vitamin D 38-47 vitamin D receptor Homo sapiens 48-51 33853023-1 2021 The hypercalcemic effects of the hormone 1alpha,25-dihydroxyvitamin D3 (calcitriol) and most of known vitamin D metabolites and analogs call for the development of non secosteroidal vitamin D receptor (VDR) ligands as new selective and noncalcemic agonists for treatment of hyperproliferative diseases. Vitamin D 60-69 vitamin D receptor Homo sapiens 182-200 32627088-1 2021 BACKGROUND: Vitamin D has anticarcinogenic properties and acts through vitamin D receptor (VDR) to carry out its functions. Vitamin D 12-21 vitamin D receptor Homo sapiens 71-89 32627088-1 2021 BACKGROUND: Vitamin D has anticarcinogenic properties and acts through vitamin D receptor (VDR) to carry out its functions. Vitamin D 12-21 vitamin D receptor Homo sapiens 91-94 34003583-1 2022 Vitamin D is used to reduce cancer risk and improve the outcome of cancer patients, but the vitamin D receptor (VDR; also known as the calcitriol receptor) pathway needs to be functionally intact to ensure the biological effects of circulating calcitriol, the active form of vitamin D. Vitamin D 92-101 vitamin D receptor Homo sapiens 112-115 34015387-0 2021 Vitamin D status in Hashimoto"s thyroiditis and its association with vitamin D receptor genetic variants. Vitamin D 0-9 vitamin D receptor Homo sapiens 69-87 34015387-13 2021 Moreover, patients with FokI AA genotype have statistically higher levels of 25-OH-vitamin D3 suggesting VDR dysfunction even in patients expressing normal level of vitamin D. Vitamin D 83-92 vitamin D receptor Homo sapiens 105-108 34054418-5 2021 The signaling of 1,25-dihydroxyvitamin D3, the active form of vitamin D, through vitamin D receptor (VDR) induces the expression of the gene of tryptophan hydroxylase 2 (TPH2), influences the expression of serotonin reuptake transporter (SERT) as well as the levels of monoamine oxidase-A (MAO-A), the enzyme responsible for serotonin catabolism. Vitamin D 31-40 vitamin D receptor Homo sapiens 81-99 34054418-5 2021 The signaling of 1,25-dihydroxyvitamin D3, the active form of vitamin D, through vitamin D receptor (VDR) induces the expression of the gene of tryptophan hydroxylase 2 (TPH2), influences the expression of serotonin reuptake transporter (SERT) as well as the levels of monoamine oxidase-A (MAO-A), the enzyme responsible for serotonin catabolism. Vitamin D 31-40 vitamin D receptor Homo sapiens 101-104 33453076-2 2021 This study aimed to investigate the effect of vitamin D supplementation by maternal and offspring vitamin D receptor (VDR) genotype and GC genotype, encoding vitamin D binding protein (VDBP), in two RCTs. Vitamin D 46-55 vitamin D receptor Homo sapiens 118-121 33453076-8 2021 CONCLUSIONS: We found that the effect of high-dose vitamin D supplementation during pregnancy on offspring risk of persistent wheeze was significantly influenced by VDR genotype in the COPSAC2010 RCT, but not VDAART, which may be due to population differences. Vitamin D 51-60 vitamin D receptor Homo sapiens 165-168 33823058-0 2021 Exercise acutely increases vitamin D receptor (VDR) expression in T-lymphocytes in vitamin D deficient men, independent of age. Vitamin D 27-36 vitamin D receptor Homo sapiens 47-50 33935807-9 2021 Additionally, VDR knockdown results in decreased mitochondrial oxidative capacity and ATP production, suggesting that vitamin D is crucial for mitochondrial oxidative phosphorylation capacity; an important driver of muscle regeneration. Vitamin D 118-127 vitamin D receptor Homo sapiens 14-17 33863283-2 2021 As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Vitamin D 3-12 vitamin D receptor Homo sapiens 59-77 33863283-2 2021 As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Vitamin D 3-12 vitamin D receptor Homo sapiens 79-82 33863283-2 2021 As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Vitamin D 3-12 vitamin D receptor Homo sapiens 85-88 33863283-2 2021 As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Vitamin D 3-12 vitamin D receptor Homo sapiens 85-88 33863283-2 2021 As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Vitamin D 59-68 vitamin D receptor Homo sapiens 79-82 33863283-2 2021 As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Vitamin D 59-68 vitamin D receptor Homo sapiens 85-88 33863283-2 2021 As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Vitamin D 59-68 vitamin D receptor Homo sapiens 85-88 33836827-11 2021 Our findings showed that the expression of VDR, ERbeta, GLUT4, and FABP4 were upregulated through differentiation with the highest concentrations in 0.1 nM vitamin D plus BPA group for VDR, ERbeta, and GLUT4. Vitamin D 156-165 vitamin D receptor Homo sapiens 43-46 33836827-11 2021 Our findings showed that the expression of VDR, ERbeta, GLUT4, and FABP4 were upregulated through differentiation with the highest concentrations in 0.1 nM vitamin D plus BPA group for VDR, ERbeta, and GLUT4. Vitamin D 156-165 vitamin D receptor Homo sapiens 185-188 33897704-5 2021 Its etiology is based on the one hand on polymorphisms within genes affecting the vitamin D system, causing susceptibility towards developing low vitamin D responsiveness and autoimmune diseases; on the other hand it is based on a blockade of vitamin D receptor signaling, e.g. through pathogen infections. Vitamin D 82-91 vitamin D receptor Homo sapiens 243-261 33823058-4 2021 Moderate intensity cycling exercise increases vitamin D receptor expression in vitamin D deficient men, independent of age, presenting a strategy to combat the vitamin D epidemic. Vitamin D 79-88 vitamin D receptor Homo sapiens 46-64 33917614-2 2021 Single nucleotide polymorphisms (SNPs) of vitamin D receptor (VDR) and vitamin D binding protein (GC gene) may interfere with vitamin D activity. Vitamin D 42-51 vitamin D receptor Homo sapiens 62-65 33823058-5 2021 ABSTRACT: Vitamin D plays a key role in the modulation of the immune system, mediated through the intracellular vitamin D receptor (VDR). Vitamin D 10-19 vitamin D receptor Homo sapiens 112-130 33823058-5 2021 ABSTRACT: Vitamin D plays a key role in the modulation of the immune system, mediated through the intracellular vitamin D receptor (VDR). Vitamin D 10-19 vitamin D receptor Homo sapiens 132-135 33712053-4 2021 RESULTS: Our results showed that vitamin D receptor (VDR), as a mediator of most actions of 1,25-dihydroxyvitamin D3, glucose trasporter-4 (GLUT4),and fatty acid binding protein-4 (FABP4) was expressed in vitamin D-treated hASCs. Vitamin D 33-42 vitamin D receptor Homo sapiens 53-56 33172802-3 2021 The study aimed to analyze the relationship between ApaI and FokI polymorphisms of the VDR gene, serum vitamin D concentration, and BMD in patients with IBD. Vitamin D 103-112 vitamin D receptor Homo sapiens 87-90 33753848-0 2021 A hierarchical regulatory network analysis of the vitamin D induced transcriptome reveals novel regulators and complete VDR dependency in monocytes. Vitamin D 50-59 vitamin D receptor Homo sapiens 120-123 33753848-8 2021 In conclusion, a directional network containing 47 partly novel primary VDR target transcription factors describes secondary responses in a highly complex vitamin D signaling cascade. Vitamin D 155-164 vitamin D receptor Homo sapiens 72-75 33735953-1 2021 OBJECTIVES: To evaluate the association of VDR polymorphisms (FokI, TaqI and ApaI) with vitamin D levels and glycemic status in type 2 diabetes patients from Southern India. Vitamin D 88-97 vitamin D receptor Homo sapiens 43-46 33866723-1 2021 OBJECTIVE: To evaluate the vitamin D receptor (VDR) gene polymorphisms and vitamin D levels in inactive hepatitis B virus (HBV) carriers. Vitamin D 27-36 vitamin D receptor Homo sapiens 47-50 33730772-1 2021 OBJECTIVES: To evaluate the association of VDR polymorphisms (FokI, TaqI and ApaI) with vitamin D levels and glycemic status in type 2 diabetes patients from Southern India. Vitamin D 88-97 vitamin D receptor Homo sapiens 43-46 33535006-15 2021 1,25-Vit D3 modulates fibroblast vitamin D enzymes through both the VDR and Pdia3 pathways in a species-dependent manner. Vitamin D 33-42 vitamin D receptor Homo sapiens 68-71 33438017-1 2021 We summarize here lessons learned from studies on skeletal and extra-skeletal functions of vitamin D in hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR) patients with a mutant, nonfunctioning vitamin D receptor (VDR). Vitamin D 91-100 vitamin D receptor Homo sapiens 204-222 33438017-1 2021 We summarize here lessons learned from studies on skeletal and extra-skeletal functions of vitamin D in hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR) patients with a mutant, nonfunctioning vitamin D receptor (VDR). Vitamin D 91-100 vitamin D receptor Homo sapiens 159-162 33438017-15 2021 HVDRR patients provide a unique opportunity to study the role of the VDR and the role of vitamin D in various human systems. Vitamin D 89-98 vitamin D receptor Homo sapiens 1-4 33418104-1 2021 The specific binding of active vitamin-D to the vitamin-D receptor (VDR) is closely related to the onset of immunological diseases. Vitamin D 31-40 vitamin D receptor Homo sapiens 48-66 33418104-1 2021 The specific binding of active vitamin-D to the vitamin-D receptor (VDR) is closely related to the onset of immunological diseases. Vitamin D 31-40 vitamin D receptor Homo sapiens 68-71 32648639-3 2021 Vitamin D has stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells. Vitamin D 0-9 vitamin D receptor Homo sapiens 93-111 33002425-1 2021 BACKGROUND: Vitamin D is a steroid hormone that exerts its actions through ligation of the vitamin D receptor (VDR), a transcription factor of the nuclear receptor family. Vitamin D 12-21 vitamin D receptor Homo sapiens 91-109 33002425-1 2021 BACKGROUND: Vitamin D is a steroid hormone that exerts its actions through ligation of the vitamin D receptor (VDR), a transcription factor of the nuclear receptor family. Vitamin D 12-21 vitamin D receptor Homo sapiens 111-114 32648639-3 2021 Vitamin D has stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells. Vitamin D 0-9 vitamin D receptor Homo sapiens 113-116 33578813-1 2021 Skeletal muscle cells, albeit classified as vitamin D receptor (VDR)-poor cells, are finely controlled by vitamin D through genomic and non-genomic mechanisms. Vitamin D 44-53 vitamin D receptor Homo sapiens 64-67 33664952-2 2021 Vitamin D is a key mediator in inflammatory and infectious diseases, which VDR mediates its biological effect. Vitamin D 0-9 vitamin D receptor Homo sapiens 75-78 33664952-11 2021 Conclusions: Strong negative correlation between VDR and HMGB1 in different immunodeficiency statuses suggesting an important role of vitamin D in inflammation control in HIV infection. Vitamin D 134-143 vitamin D receptor Homo sapiens 49-52 32715368-1 2021 INTRODUCTION: Vitamin D works by binding to vitamin D receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 44-62 32715368-1 2021 INTRODUCTION: Vitamin D works by binding to vitamin D receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 64-67 33624437-0 2021 Vitamin D Inhibits Adipokine Production and Inflammatory Signaling Through the Vitamin D Receptor in Human Adipocytes. Vitamin D 0-9 vitamin D receptor Homo sapiens 79-97 33624437-4 2021 Using RNA interference, we examined whether the vitamin D receptor (VDR) mediated vitamin D actions on adipokine expression and inflammatory signaling pathways in human adipocytes. Vitamin D 48-57 vitamin D receptor Homo sapiens 68-71 33624437-11 2021 CONCLUSION: Vitamin D acts through VDR to inhibit inflammatory pathways and adipokine expression in human adipocytes. Vitamin D 12-21 vitamin D receptor Homo sapiens 35-38 33485603-11 2021 CONCLUSION: Our results suggest that FokI and TaqI polymorphisms of VDR are associated with MS risk and TaqI polymorphism is associated with Vitamin D levels in MS patients. Vitamin D 141-150 vitamin D receptor Homo sapiens 68-71 33183376-6 2021 The cerebral vitamin D status depends upon the functionality of genetic variants of Vitamin D Receptor (VDR) and other involved genes. Vitamin D 13-22 vitamin D receptor Homo sapiens 84-102 33183376-6 2021 The cerebral vitamin D status depends upon the functionality of genetic variants of Vitamin D Receptor (VDR) and other involved genes. Vitamin D 13-22 vitamin D receptor Homo sapiens 104-107 33044390-2 2021 Mutations in the vitamin D receptor (VDR) gene can substantially affect serum vitamin D levels or alter its functionality, and can consequently increase susceptibility to developing MS. Vitamin D 17-26 vitamin D receptor Homo sapiens 37-40 33259938-9 2021 These data suggested that vitamin D/VDR could alleviate cisplatin-induced acute renal injury partly by inhibiting NF-kappaB-mediated NLRP3/Caspase-1/GSDMD pyroptosis. Vitamin D 26-35 vitamin D receptor Homo sapiens 36-39 32287103-3 2021 The pleiotropic effects of vitamin D are exerted via vitamin D receptor (VDR) and its genetic alterations could influence its functions. Vitamin D 27-36 vitamin D receptor Homo sapiens 53-71 33469344-1 2021 Purpose: To investigate the association between vitamin D receptor (VDR) gene polymorphisms and vitamin D deficiency, overweightness/obesity, and metabolic syndrome (MetS) in a cohort of Han children residing in Hangzhou, China. Vitamin D 48-57 vitamin D receptor Homo sapiens 68-71 33397237-9 2021 Of note, the DHA has higher binding interactions to the mutated VDR (PDB id: 3VT7) when compared to the standard Vitamin-D. Vitamin D 113-122 vitamin D receptor Homo sapiens 64-67 32503403-9 2021 CONCLUSION: Since vitamin D is capable of regulating the immune homeostasis and decreasing the autoimmune process through its receptor (VDR), it is regarded as a potential target for RA. Vitamin D 18-27 vitamin D receptor Homo sapiens 136-139 33452895-1 2021 We investigated the effect of vitamin D supplementation on the expression of muscle vitamin D receptor (VDR) and cross-sectional area (CSA) in patients with a distal radius fracture (DRF). Vitamin D 30-39 vitamin D receptor Homo sapiens 84-102 33452895-1 2021 We investigated the effect of vitamin D supplementation on the expression of muscle vitamin D receptor (VDR) and cross-sectional area (CSA) in patients with a distal radius fracture (DRF). Vitamin D 30-39 vitamin D receptor Homo sapiens 104-107 33452895-2 2021 Significant increases in VDR expression and CSA were observed, especially in vitamin D-deficient patients. Vitamin D 77-86 vitamin D receptor Homo sapiens 25-28 33452895-4 2021 We evaluated the change in VDR expression and CSA in the forearm muscles following vitamin D supplementation in patients with a DRF. Vitamin D 83-92 vitamin D receptor Homo sapiens 27-30 33452895-11 2021 Significant increases in VDR expression and CSA were observed in vitamin D-deficient patients [25(OH)D] < 20 ng/mL, but not in vitamin D-non-deficient patients. Vitamin D 65-74 vitamin D receptor Homo sapiens 25-28 33452895-13 2021 CONCLUSION: Vitamin D supplementation may increase muscle VDR expression and CSA in patients with a DRF, especially in vitamin D-deficient patients. Vitamin D 12-21 vitamin D receptor Homo sapiens 58-61 33452895-14 2021 The increase in CSA without an increase in VDR expression in some patients indicates that the effect of vitamin D supplementation on muscle mass could be mediated by indirect effect of serum vitamin D restoration and by VDR. Vitamin D 104-113 vitamin D receptor Homo sapiens 220-223 33436077-2 2021 The active form of vitamin D, i.e., 1,25-dihydroxyvitamin D, through the interaction with vitamin D receptor, exerts different activities on the innate and adaptive immune system, among which suppression of inflammation and promotion of tolerogenic responses. Vitamin D 19-28 vitamin D receptor Homo sapiens 90-108 33405236-3 2021 Over the last decades, extensive research has been focused on the identification of the biochemical and molecular pathways that mediate vitamin D-VDR cellular and genomic actions through which vitamin D regulates the expression of target genes and modulates the progression of liver diseases. Vitamin D 136-145 vitamin D receptor Homo sapiens 146-149 33405236-3 2021 Over the last decades, extensive research has been focused on the identification of the biochemical and molecular pathways that mediate vitamin D-VDR cellular and genomic actions through which vitamin D regulates the expression of target genes and modulates the progression of liver diseases. Vitamin D 193-202 vitamin D receptor Homo sapiens 146-149 32474936-6 2021 The bioactivity of vitamin D in hPDLCs was assessed based on the gene expression levels of vitamin D receptor (VDR) regulated genes osteocalcin and osteopontin. Vitamin D 19-28 vitamin D receptor Homo sapiens 91-109 32474936-6 2021 The bioactivity of vitamin D in hPDLCs was assessed based on the gene expression levels of vitamin D receptor (VDR) regulated genes osteocalcin and osteopontin. Vitamin D 19-28 vitamin D receptor Homo sapiens 111-114 32287103-3 2021 The pleiotropic effects of vitamin D are exerted via vitamin D receptor (VDR) and its genetic alterations could influence its functions. Vitamin D 27-36 vitamin D receptor Homo sapiens 73-76 33446057-1 2021 Vitamin D (VDR)-mediated signaling contributes to the cell signaling pathways that affect cancer development. Vitamin D 0-9 vitamin D receptor Homo sapiens 11-14 33376592-2 2020 Because vitamin D plays an important role in bone metabolism and immune system modulation, the aim of this study was to evaluate the influence of polymorphisms in vitamin D receptor genes (VDR) in the development of SpA. Vitamin D 8-17 vitamin D receptor Homo sapiens 163-181 33402842-13 2020 Conclusion: In the aggregate, these data suggest that interferons have a regulatory influence on vitamin D status that can contribute to VDR signaling in PBMCs. Vitamin D 97-106 vitamin D receptor Homo sapiens 137-140 33348854-2 2020 Vitamin D is a potent immunonutrient that through its main metabolite calcitriol, regulates the immunomodulation of macrophages, dendritic cells, T and B lymphocytes, which express the vitamin D receptor (VDR), and they produce and respond to calcitriol. Vitamin D 0-9 vitamin D receptor Homo sapiens 185-203 33348854-2 2020 Vitamin D is a potent immunonutrient that through its main metabolite calcitriol, regulates the immunomodulation of macrophages, dendritic cells, T and B lymphocytes, which express the vitamin D receptor (VDR), and they produce and respond to calcitriol. Vitamin D 0-9 vitamin D receptor Homo sapiens 205-208 33633942-0 2021 Vitamin D receptor gene ApaI and FokI polymorphisms and its association with inflammation and oxidative stress in vitamin D sufficient Caucasian Spanish children. Vitamin D 114-123 vitamin D receptor Homo sapiens 0-18 33633942-6 2021 The focus of this study was to explore associations between VDR single nucleotide polymorphisms (SNPs) and markers of inflammation and oxidative stress in vitamin D sufficient children. Vitamin D 155-164 vitamin D receptor Homo sapiens 60-63 33396382-12 2020 To move forward, we need well-designed therapeutic studies to examine whether enhanced vitamin D will restore functions of VDR and microbiome in inhibiting chronic inflammation. Vitamin D 87-96 vitamin D receptor Homo sapiens 123-126 33273558-1 2020 The vitamin D receptor (VDR), coded by the VDR gene, plays a pivotal role in executing cellular functions when bound by the active form of vitamin D. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 33365026-8 2020 Expression of IL-23A and vitamin D pathway genes VDR and CYP27B1 varied by HLA genotype and was lower in healthy individuals with high-risk HLA (p = 0.0025; p = 0.04), while healthy controls with low-risk HLA showed a stronger IL-10 and CD14 expression (p = 0.01; p = 0.03). Vitamin D 25-34 vitamin D receptor Homo sapiens 49-52 33273558-1 2020 The vitamin D receptor (VDR), coded by the VDR gene, plays a pivotal role in executing cellular functions when bound by the active form of vitamin D. Vitamin D 4-13 vitamin D receptor Homo sapiens 43-46 32771696-13 2020 The VDR is a viable target of muscle maintenance through testable Vitamin D molecules, as active molecules and analogs. Vitamin D 66-75 vitamin D receptor Homo sapiens 4-7 33004198-3 2020 RESULTS: Twelve studies in total, including 130,676 and 476 subjects, were analysed for the association between serum vitamin D levels and VDR polymorphisms with glaucoma, respectively. Vitamin D 118-127 vitamin D receptor Homo sapiens 139-142 33004198-7 2020 In addition, the vitamin D signalling cascade may be a contributing factor in developing glaucoma, which is supported by the evidence that b allele carriers of VDR BsmI exhibited an increase in the risk of glaucoma. Vitamin D 17-26 vitamin D receptor Homo sapiens 160-163 33259013-4 2020 Cytochrome enzymes CYP27B1 and CYP24A1 that perform the final conversion of the circulating form of vitamin D, 25-hydroxyvitamin D (25-OHD) to the active VDR ligand, 1a,25-dihydroxyvitamin D and the catabolism of it to inactive 24,25-dihydroxyvitamin D, respectively, are also expressed in breast cancer tissues. Vitamin D 100-109 vitamin D receptor Homo sapiens 154-157 33045433-0 2020 Insulin Sensitizing Effects of Vitamin D Repletion Mediated by Adipocyte Vitamin D Receptor: Studies in humans and mice. Vitamin D 31-40 vitamin D receptor Homo sapiens 73-91 33282119-4 2020 Vitamin D receptor is expressed in adipose tissues and vitamin D regulates multiple aspects of adipose biology including adipogenesis as well as metabolic and endocrine function of adipose tissues that can contribute to the high risk of metabolic diseases in vitamin D insufficiency. Vitamin D 259-268 vitamin D receptor Homo sapiens 0-18 33330279-14 2020 Conclusion: Exogenous factors (time of year, place of residence, and prophylactic administration of cholecalciferol), as well as endogenous factors (age and sex), play a determining role in the development of vitamin D deficiency and insufficiency; in contrast to genetic factors-polymorphic variants of the genes of xenobiotic phase 1 enzymes (CYP2C9, CYP2C19, CYP2D6, and CYP3A4) and the VDR gene-which do not play such role. Vitamin D 209-218 vitamin D receptor Homo sapiens 390-393 32583376-0 2020 Influence of Stress on the Vitamin D-Vitamin D Receptor System, Macrophages, and the Local Inflammatory Milieu in Endometriosis. Vitamin D 27-36 vitamin D receptor Homo sapiens 37-55 32583376-11 2020 Macrophage infiltration correlated with vesicle area (p < 0.05), and peritoneal vitamin D levels correlated with vesicle VDR expression (r = 0.81, p < 0.01). Vitamin D 80-89 vitamin D receptor Homo sapiens 121-124 33294462-2 2020 Vitamin D levels in DN patients are very low due to the decrease in the synthesis and activity of 1-alpha hydroxylase in the proximal tubule cells and decrease in the vitamin D receptor abundance. Vitamin D 0-9 vitamin D receptor Homo sapiens 167-185 33255834-2 2020 Vitamin D, partly mediated through the vitamin D receptor (VDR), has potential therapeutic applications in skin cancer. Vitamin D 0-9 vitamin D receptor Homo sapiens 39-57 33255834-2 2020 Vitamin D, partly mediated through the vitamin D receptor (VDR), has potential therapeutic applications in skin cancer. Vitamin D 0-9 vitamin D receptor Homo sapiens 59-62 33202670-6 2020 Vitamin D and its receptor vitamin D receptor (VDR) exert a critical role in infections due to their remarkable impact on both innate and adaptive immune responses and on the suppression of the inflammatory process. Vitamin D 0-9 vitamin D receptor Homo sapiens 27-45 33227893-1 2020 Vitamin D and its derivatives, acting via the vitamin D receptor (VDR) and retinoic acid-related orphan receptors gamma and alpha (RORgamma and RORalpha), show anticancer properties. Vitamin D 0-9 vitamin D receptor Homo sapiens 46-64 33227893-1 2020 Vitamin D and its derivatives, acting via the vitamin D receptor (VDR) and retinoic acid-related orphan receptors gamma and alpha (RORgamma and RORalpha), show anticancer properties. Vitamin D 0-9 vitamin D receptor Homo sapiens 66-69 33211721-7 2020 We found that human arteries express a functionally active vitamin D system, including the VDR, 1alpha-hydroxylase and 24-hydroxylase (24-OHase) components and these were dysregulated in CKD arteries. Vitamin D 59-68 vitamin D receptor Homo sapiens 91-94 33202670-6 2020 Vitamin D and its receptor vitamin D receptor (VDR) exert a critical role in infections due to their remarkable impact on both innate and adaptive immune responses and on the suppression of the inflammatory process. Vitamin D 0-9 vitamin D receptor Homo sapiens 47-50 33186385-2 2020 Vitamin D action takes place through vitamin D receptor (VDR) activation. Vitamin D 0-9 vitamin D receptor Homo sapiens 37-55 33216035-3 2021 Vitamin D deficit and polymorphisms of the vitamin D receptor (VDR) gene are associated with high prevalence of mild cognitive impairment (MCI) and AD. Vitamin D 0-9 vitamin D receptor Homo sapiens 43-61 33216035-3 2021 Vitamin D deficit and polymorphisms of the vitamin D receptor (VDR) gene are associated with high prevalence of mild cognitive impairment (MCI) and AD. Vitamin D 0-9 vitamin D receptor Homo sapiens 63-66 33216035-11 2021 CONCLUSION: We propose that the response to vitamin D treatment will depend on VDR polymorphisms, being more efficient in carriers of protective alleles of Apa I polymorphism. Vitamin D 44-53 vitamin D receptor Homo sapiens 79-82 33186385-2 2020 Vitamin D action takes place through vitamin D receptor (VDR) activation. Vitamin D 0-9 vitamin D receptor Homo sapiens 57-60 33186385-11 2020 CONCLUSIONS: Despite being preliminary, these findings suggest that genotyping of pregnant women for VDR polymorphisms may be useful for a tailored vitamin D supplementation strategy. Vitamin D 148-157 vitamin D receptor Homo sapiens 101-104 33165606-11 2021 Higher vitamin D levels in those in endoscopic remission compared with lower levels in those with active inflammation suggests that the impact of VDR gene SNP on disease activity may be overcome with replacement therapy. Vitamin D 7-16 vitamin D receptor Homo sapiens 146-149 32942038-3 2020 Vitamin D is a pleiotropic hormone that executes its actions on cells through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 82-100 32942038-3 2020 Vitamin D is a pleiotropic hormone that executes its actions on cells through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 102-105 32942038-7 2020 Further, intestinal VDR expression is inversely correlated with the severity of inflammation in patients with IBD, which might compromise the positive effects of vitamin D signaling in patients with flaring disease. Vitamin D 162-171 vitamin D receptor Homo sapiens 20-23 33131491-2 2020 We hypothesized that vitamin D intake should refer to vitamin D receptor (VDR) expression. Vitamin D 21-30 vitamin D receptor Homo sapiens 74-77 33131491-15 2020 It is expected that a more individualized vitamin D intake and a more accurate prognosis assessment can be recommended for BC patients based on the VDR expression. Vitamin D 42-51 vitamin D receptor Homo sapiens 148-151 33131491-2 2020 We hypothesized that vitamin D intake should refer to vitamin D receptor (VDR) expression. Vitamin D 21-30 vitamin D receptor Homo sapiens 54-72 33132636-2 2020 Vitamin D receptor (VDR) is proposed as a druggable target for NASH due to the discovery of vitamin D deficiency in NASH patients. Vitamin D 92-101 vitamin D receptor Homo sapiens 0-18 33000217-0 2020 Vitamin D receptor knockdown attenuates the antiproliferative, pro-apoptotic and anti-invasive effect of vitamin D by activating the Wnt/beta-catenin signaling pathway in papillary thyroid cancer. Vitamin D 105-114 vitamin D receptor Homo sapiens 0-18 33000217-3 2020 Therefore, the present study aimed to determine the role of the VDR and its association with Wnt/beta-catenin signaling in vitamin D-treated PTC cells. Vitamin D 123-132 vitamin D receptor Homo sapiens 64-67 33000217-11 2020 In conclusion, the present study revealed that VDR-KD attenuated the antiproliferative, pro-apoptotic and anti-invasive effects of vitamin D in PTC by activating the Wnt/beta-catenin signaling pathway. Vitamin D 131-140 vitamin D receptor Homo sapiens 47-50 33037402-5 2020 Differential methylation of Vitamin D Receptor binding sites and MS risk genes was assessed from this and using pyrosequencing for the vitamin D regulated MS risk gene ZMIZ1. Vitamin D 135-144 vitamin D receptor Homo sapiens 28-46 33067526-5 2020 Vitamin D receptor (VDR) mediates a great majority of vitamin D biological activities; specific polymorphisms of the VDR gene have been associated with different biologic responses to vitamin D. Vitamin D 54-63 vitamin D receptor Homo sapiens 0-18 33067526-5 2020 Vitamin D receptor (VDR) mediates a great majority of vitamin D biological activities; specific polymorphisms of the VDR gene have been associated with different biologic responses to vitamin D. Vitamin D 54-63 vitamin D receptor Homo sapiens 20-23 33067526-5 2020 Vitamin D receptor (VDR) mediates a great majority of vitamin D biological activities; specific polymorphisms of the VDR gene have been associated with different biologic responses to vitamin D. Vitamin D 54-63 vitamin D receptor Homo sapiens 117-120 33067526-5 2020 Vitamin D receptor (VDR) mediates a great majority of vitamin D biological activities; specific polymorphisms of the VDR gene have been associated with different biologic responses to vitamin D. Vitamin D 184-193 vitamin D receptor Homo sapiens 0-18 33067526-5 2020 Vitamin D receptor (VDR) mediates a great majority of vitamin D biological activities; specific polymorphisms of the VDR gene have been associated with different biologic responses to vitamin D. Vitamin D 184-193 vitamin D receptor Homo sapiens 20-23 33067526-5 2020 Vitamin D receptor (VDR) mediates a great majority of vitamin D biological activities; specific polymorphisms of the VDR gene have been associated with different biologic responses to vitamin D. Vitamin D 184-193 vitamin D receptor Homo sapiens 117-120 33132636-2 2020 Vitamin D receptor (VDR) is proposed as a druggable target for NASH due to the discovery of vitamin D deficiency in NASH patients. Vitamin D 92-101 vitamin D receptor Homo sapiens 20-23 33132636-4 2020 It is known that VDR can interact with other ligands such as bile acids in addition to vitamin D, and its expression can be induced by fatty acids, and insulin. Vitamin D 87-96 vitamin D receptor Homo sapiens 17-20 32900990-7 2020 Chromatin immunoprecipitation (ChIP) and assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) analyses showed that VDR transcriptionally repressed SRY-box 2 (SOX2) by binding to the vitamin D response elements in the promoter of SOX2, impairing tumor growth and drug resistance. Vitamin D 215-224 vitamin D receptor Homo sapiens 148-151 33133014-2 2020 The biologically active form of vitamin D, calcitriol, exerts anticancer effects in many cell types, both alone and in combination with chemotherapy drugs, through binding to vitamin D receptor (VDR); however, the role of calcitriol in MPM is still unknown. Vitamin D 32-41 vitamin D receptor Homo sapiens 175-193 33133014-2 2020 The biologically active form of vitamin D, calcitriol, exerts anticancer effects in many cell types, both alone and in combination with chemotherapy drugs, through binding to vitamin D receptor (VDR); however, the role of calcitriol in MPM is still unknown. Vitamin D 32-41 vitamin D receptor Homo sapiens 195-198 32846212-8 2020 Moreover, the neuroprotective effects of vitamin D and dehydroepiandrosterone (DHEA) are mediated through the binding to vitamin D receptor (VDR) and several intracellular and membrane receptors, respectively. Vitamin D 41-50 vitamin D receptor Homo sapiens 141-144 33070539-6 2020 Finally, we hypothesize that endothelial dysfunction relevant to vitamin D deficiency results from decreased binding of the vitamin D receptor with its ligand on the vascular endothelium and that it may be immune-mediated via increased interferon 1 alpha. Vitamin D 65-74 vitamin D receptor Homo sapiens 124-142 33029399-0 2020 Association of Vitamin D with the TaqI Polymorphism of the VDR Gene in Older Women Attending the Basic Health Unit of the Federal District, DF (Brazil). Vitamin D 15-24 vitamin D receptor Homo sapiens 59-62 33029399-4 2020 The VDR gene TaqI polymorphism may modify the vitamin D metabolic pathway by altering the interaction between the vitamin D receptor and the active circulating vitamin D. Vitamin D 46-55 vitamin D receptor Homo sapiens 4-7 33029399-4 2020 The VDR gene TaqI polymorphism may modify the vitamin D metabolic pathway by altering the interaction between the vitamin D receptor and the active circulating vitamin D. Vitamin D 46-55 vitamin D receptor Homo sapiens 114-132 33029399-4 2020 The VDR gene TaqI polymorphism may modify the vitamin D metabolic pathway by altering the interaction between the vitamin D receptor and the active circulating vitamin D. Vitamin D 114-123 vitamin D receptor Homo sapiens 4-7 33029399-5 2020 Therefore, this study aimed to investigate the association between serum vitamin D and biochemical and genetic factors, considering the TaqI polymorphism of the VDR gene, in an elderly population of the Federal District. Vitamin D 73-82 vitamin D receptor Homo sapiens 161-164 32846212-8 2020 Moreover, the neuroprotective effects of vitamin D and dehydroepiandrosterone (DHEA) are mediated through the binding to vitamin D receptor (VDR) and several intracellular and membrane receptors, respectively. Vitamin D 41-50 vitamin D receptor Homo sapiens 121-139 32952100-9 2021 H-scores for VDR, Claudin-2 and E-cadherin were significantly lower in patients with vitamin D deficiency compared to patients with normal vitamin D level. Vitamin D 85-94 vitamin D receptor Homo sapiens 13-16 32952100-10 2021 There were positive correlations between 25-OH vitamin D level and H-scores for VDR, E-cadherin and Claudin-2 in patient group. Vitamin D 47-56 vitamin D receptor Homo sapiens 80-83 32952100-13 2021 Furthermore, deficiency of vitamin D was related to decreased expression of VDR and epithelial barrier proteins E-cadherin and Claudin-2. Vitamin D 27-36 vitamin D receptor Homo sapiens 76-79 32900990-9 2020 These findings reveal a new mechanism by which acidosis could affect the stemness of CRC cells by regulating the expression of SOX2 and show that abnormal VDR expression leads to ineffective activation of vitamin D signaling, resulting in a lack of efficacy of vitamin D in antineoplastic process. Vitamin D 205-214 vitamin D receptor Homo sapiens 155-158 32900990-9 2020 These findings reveal a new mechanism by which acidosis could affect the stemness of CRC cells by regulating the expression of SOX2 and show that abnormal VDR expression leads to ineffective activation of vitamin D signaling, resulting in a lack of efficacy of vitamin D in antineoplastic process. Vitamin D 261-270 vitamin D receptor Homo sapiens 155-158 32899460-2 2020 The depletion of vitamin D seems to play a role in the fragilization of old persons, and genetic polymorphisms of the vitamin D receptor (VDR) gene seem to be involved in regulating the vitamin D pathway. Vitamin D 118-127 vitamin D receptor Homo sapiens 138-141 32911795-2 2020 Recently, new and interesting aspects of vitamin D metabolism has been elucidated, namely the special role of the skin, the metabolic control of liver hydroxylase CYP2R1, the specificity of 1alpha-hydroxylase in different tissues and cell types and the genomic, non-genomic and epigenomic effects of vitamin D receptor, which will be addressed in the present review. Vitamin D 41-50 vitamin D receptor Homo sapiens 300-318 32379895-2 2020 The action of calcitriol, the active metabolite of vitamin D, is mediated by the vitamin D receptor (VDR) that is present in most tissues. Vitamin D 51-60 vitamin D receptor Homo sapiens 81-99 32899880-3 2020 However, the observation of seasonal changes in blood pressure and the subsequent identification of vitamin D receptor (VDR) and 1alpha-hydroxylase in cardiomyocytes, as well as endothelial and vascular smooth muscle cells, implicated a role of vitamin D in the cardiovascular system. Vitamin D 100-109 vitamin D receptor Homo sapiens 120-123 32986367-1 2020 BACKGROUND: Vitamin D inhibits cell proliferation via the vitamin D receptor (VDR), which may affect breast cancer risk. Vitamin D 12-21 vitamin D receptor Homo sapiens 58-76 32986367-1 2020 BACKGROUND: Vitamin D inhibits cell proliferation via the vitamin D receptor (VDR), which may affect breast cancer risk. Vitamin D 12-21 vitamin D receptor Homo sapiens 78-81 31232112-9 2020 CONCLUSION: It is known that active vitamin D inhibits the growth of cancer cells by binding to vitamin D receptor with regulation of genes responsible for cell proliferation. Vitamin D 36-45 vitamin D receptor Homo sapiens 96-114 32379895-2 2020 The action of calcitriol, the active metabolite of vitamin D, is mediated by the vitamin D receptor (VDR) that is present in most tissues. Vitamin D 51-60 vitamin D receptor Homo sapiens 101-104 32379895-13 2020 New vitamin D treatment studies that examine CRC should take in account confounding factors such as obesity or VDR genotypes. Vitamin D 4-13 vitamin D receptor Homo sapiens 111-114 32654294-1 2020 The genomic actions of the vitamin D are mediated via its biologically most potent metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ) and the transcription factor vitamin D receptor (VDR). Vitamin D 27-36 vitamin D receptor Homo sapiens 169-187 32654294-1 2020 The genomic actions of the vitamin D are mediated via its biologically most potent metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ) and the transcription factor vitamin D receptor (VDR). Vitamin D 27-36 vitamin D receptor Homo sapiens 189-192 32654294-7 2020 Furthermore, also VDR seems to play a role in membrane-based responses to vitamin D. Vitamin D 74-83 vitamin D receptor Homo sapiens 18-21 32939414-11 2020 Conclusion: Our review shows significant associations with VDR polymorphisms - Apa1, Bsm1, Fok 1, Taq 1, polymorphisms of Vitamin D metabolic genes - CYP27A1, CYP 2R1, CYP 24A1, GC and genes related to Vitamin D response element (VDRE) in children with asthma. Vitamin D 122-131 vitamin D receptor Homo sapiens 59-62 32939414-11 2020 Conclusion: Our review shows significant associations with VDR polymorphisms - Apa1, Bsm1, Fok 1, Taq 1, polymorphisms of Vitamin D metabolic genes - CYP27A1, CYP 2R1, CYP 24A1, GC and genes related to Vitamin D response element (VDRE) in children with asthma. Vitamin D 202-211 vitamin D receptor Homo sapiens 59-62 32880832-3 2020 Vitamin D is able to modulate a very specific immune response against MTB infection, and its action relies on vitamin D receptor (VDR) binding. Vitamin D 0-9 vitamin D receptor Homo sapiens 110-128 32592616-3 2020 The role of vitamin D is mediated by vitamin D receptors (VDR) in target cells. Vitamin D 12-21 vitamin D receptor Homo sapiens 37-56 32592616-3 2020 The role of vitamin D is mediated by vitamin D receptors (VDR) in target cells. Vitamin D 12-21 vitamin D receptor Homo sapiens 58-61 32880832-3 2020 Vitamin D is able to modulate a very specific immune response against MTB infection, and its action relies on vitamin D receptor (VDR) binding. Vitamin D 0-9 vitamin D receptor Homo sapiens 130-133 32880832-4 2020 Altered VDR forms may compromise vitamin D pathway and proper immune response after MTB infection. Vitamin D 33-42 vitamin D receptor Homo sapiens 8-11 32627899-4 2020 Vitamin D deficient (VitD-Def) subjects (25(OH)D3 level < 26 ng/mL) expressed significant downregulation of vitamin D receptor (VDR) on monocytes as compared to controls (P < .0001), and VDR expression was well-associated with serum 25(OH)D3 levels. Vitamin D 0-9 vitamin D receptor Homo sapiens 108-126 32847384-0 2022 Methylation Status of VDR Gene and its Association with Vitamin D Status and VDR Gene Expression in Pediatric Tuberculosis Disease. Vitamin D 56-65 vitamin D receptor Homo sapiens 22-25 32847384-2 2022 Therefore, we aimed to study the effect of vitamin D receptor (VDR) gene methylation on plasma vitamin D level and the expression of the VDR gene in children with active-TB disease. Vitamin D 43-52 vitamin D receptor Homo sapiens 63-66 32847384-6 2022 The VDR hypermethylation is significantly associated with reduced vitamin D level and decreased expression level of VDR gene. Vitamin D 66-75 vitamin D receptor Homo sapiens 4-7 32628073-10 2020 Our findings suggest that 25OHD-Gluc, a vitamin D metabolite found in bile, induces VDR-mediated responses in the colon by crossing the apical membrane of the colon epithelium. Vitamin D 40-49 vitamin D receptor Homo sapiens 84-87 32467291-7 2020 Ingenuity pathway analysis was performed to identify upstream regulators and downstream signaling pathway genes differentially regulated by vitamin D, including TP63 and vitamin D receptor (VDR) mediated canonical pathways in particular. Vitamin D 140-149 vitamin D receptor Homo sapiens 170-188 32467291-7 2020 Ingenuity pathway analysis was performed to identify upstream regulators and downstream signaling pathway genes differentially regulated by vitamin D, including TP63 and vitamin D receptor (VDR) mediated canonical pathways in particular. Vitamin D 140-149 vitamin D receptor Homo sapiens 190-193 32952510-1 2020 Background: Polymorphisms in the gene encoding the vitamin D receptor (VDR) affect the protective role of vitamin D against many types of cancers, including colorectal cancer (CRC). Vitamin D 51-60 vitamin D receptor Homo sapiens 71-74 32867112-9 2020 RESULTS: Rs731236 (VDR gene) and rs7116978 (CYP2R1 gene) showed a significant association with vitamin D status. Vitamin D 95-104 vitamin D receptor Homo sapiens 19-22 32627899-4 2020 Vitamin D deficient (VitD-Def) subjects (25(OH)D3 level < 26 ng/mL) expressed significant downregulation of vitamin D receptor (VDR) on monocytes as compared to controls (P < .0001), and VDR expression was well-associated with serum 25(OH)D3 levels. Vitamin D 0-9 vitamin D receptor Homo sapiens 128-131 32627899-4 2020 Vitamin D deficient (VitD-Def) subjects (25(OH)D3 level < 26 ng/mL) expressed significant downregulation of vitamin D receptor (VDR) on monocytes as compared to controls (P < .0001), and VDR expression was well-associated with serum 25(OH)D3 levels. Vitamin D 0-9 vitamin D receptor Homo sapiens 187-190 32834827-10 2020 The allele C of rs9279 on VDR, was negatively associated with asthma risk (OR = 0.66; 95% CI 0.45-0.97), vitamin D insufficiency (OR = 0.78; 95% CI 0.70-0.96) and higher VDR expression. Vitamin D 105-114 vitamin D receptor Homo sapiens 26-29 32686744-0 2020 The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial. Vitamin D 14-23 vitamin D receptor Homo sapiens 43-46 32686744-4 2020 The objective of this randomised controlled study is to examine the effect of vitamin D supplementation on body composition and the expression of the vitamin D receptor (VDR) mRNA. Vitamin D 78-87 vitamin D receptor Homo sapiens 170-173 33583806-7 2020 For the setting off and regulation of particular genes, calcitriol-VDR-RXR complex attach to definite DNA fragments called as vitamin D response elements (VDREs). Vitamin D 126-135 vitamin D receptor Homo sapiens 67-70 32251673-6 2020 Vitamin D promoted primary human ATII cells proliferation through the PI3K/AKT signaling pathway and activation of vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 115-133 32251673-6 2020 Vitamin D promoted primary human ATII cells proliferation through the PI3K/AKT signaling pathway and activation of vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 135-138 32251673-7 2020 Moreover, vitamin D inhibited EMT in response to TGF-beta, which was vitamin D receptor dependent. Vitamin D 10-19 vitamin D receptor Homo sapiens 69-87 32361296-4 2020 Herein, we present the synthesis of vitamin D compounds, designed on the basis of molecular modeling and docking experiments to the vitamin D receptor, and characterized by the presence of significantly different two side chains attached to C-20. Vitamin D 36-45 vitamin D receptor Homo sapiens 132-150 32361296-9 2020 The target vitamin D compounds, displaying significant affinity for a vitamin D receptor, were assessed in vitro for their anti-proliferative activities towards several cell lines. Vitamin D 11-20 vitamin D receptor Homo sapiens 70-88 32670515-3 2020 Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia. Vitamin D 6-15 vitamin D receptor Homo sapiens 93-111 32670515-3 2020 Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia. Vitamin D 6-15 vitamin D receptor Homo sapiens 113-116 32670515-3 2020 Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia. Vitamin D 68-77 vitamin D receptor Homo sapiens 93-111 32670515-3 2020 Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia. Vitamin D 68-77 vitamin D receptor Homo sapiens 113-116 32560347-2 2020 Vitamin D deficiency has been largely associated with various types of solid and non-solid human cancers, and the almost ubiquitous expression of vitamin D receptor (VDR) has always led to suppose a crucial role of vitamin D in cancer. Vitamin D 146-155 vitamin D receptor Homo sapiens 166-169 32464532-11 2020 CONCLUSIONS: Our results suggest that GC-rs4588 is associated with lower serum 25(OH)D concentration in both Malaysian CWE and healthy children, while VDR-rs7975232A is associated with lower risk of vitamin D deficiency in Malaysian CWE of Malay ethnicity. Vitamin D 199-208 vitamin D receptor Homo sapiens 151-154 32545801-2 2020 The active form of vitamin D (1,25(OH)2D3), which acts via its nuclear hormone receptor, vitamin D receptor (VDR), has been implicated in the treatment of Abeta pathology, and is thus considered as a neuroprotective agent. Vitamin D 19-28 vitamin D receptor Homo sapiens 89-107 32626760-1 2020 Vitamin D and its cognate intracellular nuclear receptor, namely, vitamin D receptor (VDR), are involved in the regulation of a variety of body metabolic processes, immune function, and oncogenesis. Vitamin D 0-9 vitamin D receptor Homo sapiens 66-84 32626760-1 2020 Vitamin D and its cognate intracellular nuclear receptor, namely, vitamin D receptor (VDR), are involved in the regulation of a variety of body metabolic processes, immune function, and oncogenesis. Vitamin D 0-9 vitamin D receptor Homo sapiens 86-89 32545801-2 2020 The active form of vitamin D (1,25(OH)2D3), which acts via its nuclear hormone receptor, vitamin D receptor (VDR), has been implicated in the treatment of Abeta pathology, and is thus considered as a neuroprotective agent. Vitamin D 19-28 vitamin D receptor Homo sapiens 109-112 32534577-0 2020 Genetic variants of VDR and CYP2R1 affect BMI independently of serum vitamin D concentrations. Vitamin D 69-78 vitamin D receptor Homo sapiens 20-23 32493333-4 2020 However, little is known about local vitamin D metabolism in the airways and studies examining expression of the vitamin D receptor (VDR), the activating enzyme (CYP27B1) and inactivating enzyme (CYP24A1) of vitamin D in lung tissue of COPD patients are lacking. Vitamin D 113-122 vitamin D receptor Homo sapiens 133-136 32534577-5 2020 We selected 23 target SNPs in five genes that encode key proteins of vitamin D metabolism (NADSYN1, GC, CYP24A1, CYP2R1, VDR). Vitamin D 69-78 vitamin D receptor Homo sapiens 121-124 32462983-2 2021 Vitamin D receptor (VDR) is a part of the nuclear receptor family exerts vitamin D activation to maintain calcium/phosphorous homeostasis and bone metabolism. Vitamin D 73-82 vitamin D receptor Homo sapiens 0-18 32462983-2 2021 Vitamin D receptor (VDR) is a part of the nuclear receptor family exerts vitamin D activation to maintain calcium/phosphorous homeostasis and bone metabolism. Vitamin D 73-82 vitamin D receptor Homo sapiens 20-23 32462983-3 2021 The reduction of VDR activity leads to vitamin D deficiency. Vitamin D 39-48 vitamin D receptor Homo sapiens 17-20 31868234-2 2020 Binding of the active vitamin D metabolite, 1,25-dihydroxy vitamin D3 (1,25(OH)2 D3 ) to the vitamin D receptor (VDR) induces conformational changes in its C-terminal domain enabling competency for interaction with physiologically relevant coactivators, including SRC-1. Vitamin D 22-31 vitamin D receptor Homo sapiens 93-111 30221569-2 2020 Vitamin D receptor (VDR) acts as a transcription factor and regulates a number of vitamin D-responsive genes, including those involved in the immune system. Vitamin D 82-91 vitamin D receptor Homo sapiens 0-18 30221569-2 2020 Vitamin D receptor (VDR) acts as a transcription factor and regulates a number of vitamin D-responsive genes, including those involved in the immune system. Vitamin D 82-91 vitamin D receptor Homo sapiens 20-23 30221569-3 2020 Recent finding that VDR is expressed in reproductive tissues suggests a possible importance of vitamin D in pregnancy. Vitamin D 95-104 vitamin D receptor Homo sapiens 20-23 30221569-10 2020 By changing the expression and the activity of VDR gene, which leads to the change in expression of vitamin D-responsive genes, these polymorphisms and haplotypes could possibly have an effect on immune system in the female reproductive tract. Vitamin D 100-109 vitamin D receptor Homo sapiens 47-50 30789807-0 2020 Association Between Bat Vitamin D Receptor 3" Haplotypes and Vitamin D Levels at Baseline and a Lower Response After Increased Vitamin D Supplementation and Exposure to Sunlight. Vitamin D 61-70 vitamin D receptor Homo sapiens 24-42 30789807-1 2020 Objective: The aim of this study was to evaluate the relationship between vitamin D levels at baseline and after 12 weeks of supplementation/exposure to sunlight and VDR genotypes (BsmI, TaqI and ApaI) and haplotypes in a homogeneous population of postmenopausal women. Vitamin D 74-83 vitamin D receptor Homo sapiens 166-169 31868234-2 2020 Binding of the active vitamin D metabolite, 1,25-dihydroxy vitamin D3 (1,25(OH)2 D3 ) to the vitamin D receptor (VDR) induces conformational changes in its C-terminal domain enabling competency for interaction with physiologically relevant coactivators, including SRC-1. Vitamin D 22-31 vitamin D receptor Homo sapiens 113-116 32278787-7 2020 The best affinity score (-11.0 kcal/mol) was obtained for flucythrinate with the nuclear receptor for vitamin D (VDR). Vitamin D 102-111 vitamin D receptor Homo sapiens 113-116 32213352-8 2020 Increased VDR and decreased CRAMP expression are consistent with previously reported associations between vitamin D deficiency, immune dysregulation, and suicidal behavior, and should lead to future studies uncovering novel interactive targets for suicide prevention. Vitamin D 106-115 vitamin D receptor Homo sapiens 10-13 32194242-2 2020 Vitamin D can impact the function of virtually every cell in the gut by binding to its intracellular receptor (VDR) and subsequently transcribing relevant genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 111-114 32536905-1 2020 Vitamin D is a fat-soluble secosteroid that exerts its effects by binding to the vitamin D receptor (VDR), through which it directly and indirectly modulates the expression of hundreds to thousands of genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 81-99 31959263-10 2020 However, VDR polymorphisms modified associations between vitamin D and some cardiometabolic markers in children. Vitamin D 57-66 vitamin D receptor Homo sapiens 9-12 31959263-11 2020 This warrants further investigation of the role of VDR in the relationship between vitamin D-status and cardiometabolic risk. Vitamin D 83-92 vitamin D receptor Homo sapiens 51-54 32485310-2 2022 The biologically most active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) is a high affinity ligand of the transcription factor vitamin D receptor (VDR). Vitamin D 29-38 vitamin D receptor Homo sapiens 148-166 32485310-2 2022 The biologically most active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) is a high affinity ligand of the transcription factor vitamin D receptor (VDR). Vitamin D 29-38 vitamin D receptor Homo sapiens 168-171 32471257-2 2020 Vitamin D mediates its action through the binding of the vitamin D receptor (VDR), and polymorphisms of the VDR might explain these inverse associations. Vitamin D 0-9 vitamin D receptor Homo sapiens 57-75 32471257-2 2020 Vitamin D mediates its action through the binding of the vitamin D receptor (VDR), and polymorphisms of the VDR might explain these inverse associations. Vitamin D 0-9 vitamin D receptor Homo sapiens 77-80 32471257-2 2020 Vitamin D mediates its action through the binding of the vitamin D receptor (VDR), and polymorphisms of the VDR might explain these inverse associations. Vitamin D 0-9 vitamin D receptor Homo sapiens 108-111 32536905-1 2020 Vitamin D is a fat-soluble secosteroid that exerts its effects by binding to the vitamin D receptor (VDR), through which it directly and indirectly modulates the expression of hundreds to thousands of genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 101-104 32083397-2 2020 Vitamin D binds to the vitamin D Receptor (VDR); the biological activity of the ensuing complex depends on VDR FokI, BsmI, ApaI, and TaqI gene polymorphisms. Vitamin D 0-9 vitamin D receptor Homo sapiens 23-41 31961707-0 2020 TGF-beta1 promotes vitamin D-induced prostaglandin E2 synthesis by upregulating vitamin D receptor expression in human granulosa-lutein cells. Vitamin D 19-28 vitamin D receptor Homo sapiens 80-98 31961707-1 2020 There is increasing evidence showing the importance of vitamin D (Vit D) and its nuclear receptor, the Vit D receptor (VDR), in female reproductive health. Vitamin D 55-64 vitamin D receptor Homo sapiens 103-117 31961707-1 2020 There is increasing evidence showing the importance of vitamin D (Vit D) and its nuclear receptor, the Vit D receptor (VDR), in female reproductive health. Vitamin D 55-64 vitamin D receptor Homo sapiens 119-122 31961707-7 2020 Our findings indicate that TGF-beta1 upregulates the expression of VDR, which promotes Vit D-induced COX-2 expression and subsequent PGE2 production by activating the SMAD3 and ERK1/2 signaling pathways in hGL cells. Vitamin D 87-92 vitamin D receptor Homo sapiens 67-70 32083397-2 2020 Vitamin D binds to the vitamin D Receptor (VDR); the biological activity of the ensuing complex depends on VDR FokI, BsmI, ApaI, and TaqI gene polymorphisms. Vitamin D 0-9 vitamin D receptor Homo sapiens 43-46 32083397-2 2020 Vitamin D binds to the vitamin D Receptor (VDR); the biological activity of the ensuing complex depends on VDR FokI, BsmI, ApaI, and TaqI gene polymorphisms. Vitamin D 0-9 vitamin D receptor Homo sapiens 107-110 31870913-3 2020 The aim of this study was to evaluate the effect of maternal and neonatal VDR polymorphisms (ApaI, TaqI, BsmI, FokI, Tru9I) on maternal and neonatal vitamin D status. Vitamin D 149-158 vitamin D receptor Homo sapiens 74-77 32229699-1 2020 The transcription factor vitamin D receptor (VDR) is the exclusive nuclear target of the biologically active form of vitamin D (1,25(OH)2D3). Vitamin D 25-34 vitamin D receptor Homo sapiens 45-48 32229699-3 2020 Machine learning and statistical analysis as well as a comparison with the re-analyzed B cell VDR cistrome indicated a subgroup of 339 highly conserved persistent VDR sites that were suited best for describing vitamin D-triggered gene regulatory scenarios. Vitamin D 210-219 vitamin D receptor Homo sapiens 94-97 32229699-3 2020 Machine learning and statistical analysis as well as a comparison with the re-analyzed B cell VDR cistrome indicated a subgroup of 339 highly conserved persistent VDR sites that were suited best for describing vitamin D-triggered gene regulatory scenarios. Vitamin D 210-219 vitamin D receptor Homo sapiens 163-166 32229699-6 2020 The number of persistent and transient VDR sites was found to be the main discriminator for sorting these TADs into five classes carrying vitamin D target genes involved in distinct biological processes. Vitamin D 138-147 vitamin D receptor Homo sapiens 39-42 32229699-7 2020 In conclusion, specific regulation of biological processes by vitamin D depends on differences in time-dependent VDR binding. Vitamin D 62-71 vitamin D receptor Homo sapiens 113-116 32004705-2 2020 Vitamin D (1,25(OH)2D) is an important mediator of skeletal homeostasis that mediates its effect by binding to vitamin D receptor (VDR), a steroid family receptor and modulates various downstream pathways. Vitamin D 0-9 vitamin D receptor Homo sapiens 111-129 32353972-3 2020 The first hint of the significant role of vitamin D on the immune system was made by the discovery of the presence of the vitamin D receptor on almost all cells of the immune system. Vitamin D 42-51 vitamin D receptor Homo sapiens 122-140 32004705-2 2020 Vitamin D (1,25(OH)2D) is an important mediator of skeletal homeostasis that mediates its effect by binding to vitamin D receptor (VDR), a steroid family receptor and modulates various downstream pathways. Vitamin D 0-9 vitamin D receptor Homo sapiens 131-134 32004706-8 2020 In vitro, rhFGF23 countered vitamin D-stimulated osteoblast differentiation of hMSCs by reducing the vitamin D receptor, CYP27B1/1alpha-hydroxylase, biosynthesis of 1alpha,25(OH)2D3, and signaling through BMP-7. Vitamin D 28-37 vitamin D receptor Homo sapiens 101-119 32049653-0 2020 Hereditary vitamin D-resistant rickets: a report of four cases with two novel variants in the VDR gene and successful use of intermittent intravenous calcium via a peripheral route. Vitamin D 11-20 vitamin D receptor Homo sapiens 94-97 32049653-1 2020 Background Hereditary vitamin D-resistant rickets (HVDRR) is caused by vitamin D receptor (VDR) defects. Vitamin D 22-31 vitamin D receptor Homo sapiens 71-89 32049653-1 2020 Background Hereditary vitamin D-resistant rickets (HVDRR) is caused by vitamin D receptor (VDR) defects. Vitamin D 22-31 vitamin D receptor Homo sapiens 52-55 32067036-2 2020 Vitamin D receptor is widely distributed in male and female reproductive systems, suggesting that vitamin D is essential for fertility. Vitamin D 98-107 vitamin D receptor Homo sapiens 0-18 32349265-2 2020 At the molecular level, the hormonal form of vitamin D signals through the nuclear vitamin D receptor (VDR), a ligand-regulated transcription factor. Vitamin D 45-54 vitamin D receptor Homo sapiens 83-101 32349265-2 2020 At the molecular level, the hormonal form of vitamin D signals through the nuclear vitamin D receptor (VDR), a ligand-regulated transcription factor. Vitamin D 45-54 vitamin D receptor Homo sapiens 103-106 33029248-1 2020 Context: Vitamin D is a steroid hormone that acts by binding to the vitamin D receptor (VDR) found in many tissues. Vitamin D 9-18 vitamin D receptor Homo sapiens 68-86 33029248-1 2020 Context: Vitamin D is a steroid hormone that acts by binding to the vitamin D receptor (VDR) found in many tissues. Vitamin D 9-18 vitamin D receptor Homo sapiens 88-91 31210464-3 2020 Indeed, Vitamin D, through its receptor (VDR), decreases keratinocyte proliferation, improve their differentiation and modulate both cutaneous innate (antimicrobial activity and antigen presentation)and adaptative immunity (T and B lymphocyte function). Vitamin D 8-17 vitamin D receptor Homo sapiens 41-44 31686401-1 2020 PURPOSE: Turner syndrome (TS) patients display considerable immune misregulation, and it is hypothesized that Vitamin D (VTD) activity may fluctuate according to Vitamin D receptor (VDR) polymorphisms and/or expression profile. Vitamin D 110-119 vitamin D receptor Homo sapiens 162-180 31686401-1 2020 PURPOSE: Turner syndrome (TS) patients display considerable immune misregulation, and it is hypothesized that Vitamin D (VTD) activity may fluctuate according to Vitamin D receptor (VDR) polymorphisms and/or expression profile. Vitamin D 110-119 vitamin D receptor Homo sapiens 182-185 31686401-1 2020 PURPOSE: Turner syndrome (TS) patients display considerable immune misregulation, and it is hypothesized that Vitamin D (VTD) activity may fluctuate according to Vitamin D receptor (VDR) polymorphisms and/or expression profile. Vitamin D 121-124 vitamin D receptor Homo sapiens 162-180 31686401-1 2020 PURPOSE: Turner syndrome (TS) patients display considerable immune misregulation, and it is hypothesized that Vitamin D (VTD) activity may fluctuate according to Vitamin D receptor (VDR) polymorphisms and/or expression profile. Vitamin D 121-124 vitamin D receptor Homo sapiens 182-185 32489362-4 2020 Meanwhile, the vitamin D levels in patients with chronic spontaneous urticaria were also detected and the effects of VDR gene polymorphism on vitamin D levels were detected. Vitamin D 142-151 vitamin D receptor Homo sapiens 117-120 31809868-13 2020 In addition, leptin downregulated CYP24A1 and upregulated CYP27B1, CYP27A1 and VDR, which play vital roles in vitamin D metabolism. Vitamin D 110-119 vitamin D receptor Homo sapiens 79-82 32029884-8 2020 We then discuss the epidermis and hair follicle, to provide a non-skeletal example of a tissue that expresses VDR that not only makes vitamin D but also can metabolize it to its hormonally active form. Vitamin D 134-143 vitamin D receptor Homo sapiens 110-113 32489362-8 2020 However, the effect of VDR gene polymorphism on vitamin D levels was not found in patients of CSU. Vitamin D 48-57 vitamin D receptor Homo sapiens 23-26 32208427-12 2020 Stress fracture risk in RM recruits is impacted by the interaction of VDR genotype with vitamin D status. Vitamin D 88-97 vitamin D receptor Homo sapiens 70-73 32213983-5 2020 They were rapidly induced (4-6 h) upon VDR activation by 10 nM VitD or 100 microM lithocholic acid (LCA). Vitamin D 63-67 vitamin D receptor Homo sapiens 39-42 32213983-3 2020 We developed an adenoviral vector for human VDR and performed transcriptomic and metabolomic analyses of cultured human hepatocytes upon VDR activation by vitamin D (VitD). Vitamin D 155-164 vitamin D receptor Homo sapiens 137-140 32174704-2 2020 As Vitamin D metabolism and its receptor activity are important factors in human native immune system against some microorganisms, we hypothesized that VDR gene polymorphisms and concentration of Vitamin D might have effect on incidence of cutaneous leishmaniasis. Vitamin D 3-12 vitamin D receptor Homo sapiens 152-155 31984787-5 2020 Vitamin D receptor (VDR) was found to be highly expressed at the distal region of small intestine, where the vitamin D signaling promotes innate immunity, including the expression of alpha-defensins by Paneth cells, and maintains the intestinal tight junctions. Vitamin D 109-118 vitamin D receptor Homo sapiens 0-18 31984787-5 2020 Vitamin D receptor (VDR) was found to be highly expressed at the distal region of small intestine, where the vitamin D signaling promotes innate immunity, including the expression of alpha-defensins by Paneth cells, and maintains the intestinal tight junctions. Vitamin D 109-118 vitamin D receptor Homo sapiens 20-23 31377232-2 2020 Vitamin D endocrinology started when some 550 million years ago first species developed a vitamin D receptor (VDR) that binds with high affinity the vitamin D metabolite 1alpha,25-dihydroxyvitamin D3. Vitamin D 0-9 vitamin D receptor Homo sapiens 90-108 31377232-2 2020 Vitamin D endocrinology started when some 550 million years ago first species developed a vitamin D receptor (VDR) that binds with high affinity the vitamin D metabolite 1alpha,25-dihydroxyvitamin D3. Vitamin D 0-9 vitamin D receptor Homo sapiens 110-113 31377232-2 2020 Vitamin D endocrinology started when some 550 million years ago first species developed a vitamin D receptor (VDR) that binds with high affinity the vitamin D metabolite 1alpha,25-dihydroxyvitamin D3. Vitamin D 90-99 vitamin D receptor Homo sapiens 110-113 32183826-2 2020 This study was designed to assess how expression of the endometrial vitamin D receptor (VDR) and CYP27B1, a vitamin D metabolizing enzyme, change during the menstrual cycle in women of reproductive age. Vitamin D 68-77 vitamin D receptor Homo sapiens 88-91 32183826-9 2020 In addition, serum vitamin D levels were positively correlated with VDR and HOXA10 protein levels in the endometrium. Vitamin D 19-28 vitamin D receptor Homo sapiens 68-71 31940245-2 2020 The biological actions of vitamin D are carried out via the binding of 1a,25-dihydroxyvitamin D3 (1a,25(OH)2D3) to the vitamin D receptor (VDR). Vitamin D 26-35 vitamin D receptor Homo sapiens 119-137 31940245-2 2020 The biological actions of vitamin D are carried out via the binding of 1a,25-dihydroxyvitamin D3 (1a,25(OH)2D3) to the vitamin D receptor (VDR). Vitamin D 26-35 vitamin D receptor Homo sapiens 139-142 31940245-10 2020 In summary, we highlight a direct role for the VDR in regulating skeletal muscle mitochondrial respiration in vitro, providing a potential mechanism as to how vitamin D deficiency might impact upon skeletal muscle oxidative capacity. Vitamin D 159-168 vitamin D receptor Homo sapiens 47-50 31587178-3 2020 The active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3) acts as an anti-proliferative agent in human cancer by inhibiting the Wnt/beta-catenin pathway through the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 188-206 31587178-3 2020 The active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3) acts as an anti-proliferative agent in human cancer by inhibiting the Wnt/beta-catenin pathway through the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 208-211 32056782-1 2020 INTRODUCTION: Vitamin D catabolizing enzymes, along with vitamin D receptor (VDR) and vitamin D binding protein (DBP) are expressed in the decidua and placenta during pregnancy and capable of synthesizing active vitamin D. Vitamin D 14-23 vitamin D receptor Homo sapiens 77-80 32056782-1 2020 INTRODUCTION: Vitamin D catabolizing enzymes, along with vitamin D receptor (VDR) and vitamin D binding protein (DBP) are expressed in the decidua and placenta during pregnancy and capable of synthesizing active vitamin D. Vitamin D 57-66 vitamin D receptor Homo sapiens 77-80 32127758-3 2020 It is not yet clear whether the level of vitamin D and its receptor, vitamin D receptor (VDR), in the blood are helpful factors in the diagnosis of CRC. Vitamin D 41-50 vitamin D receptor Homo sapiens 89-92 32042037-2 2020 A case-control study was conducted to study the influence of vitamin D status and genotpye for 24 SNPs in four genes in the vitamin D pathway (VDR, DBP, CYP27B1, CYP24A1) on PCOS. Vitamin D 124-133 vitamin D receptor Homo sapiens 143-146 31926093-1 2020 Background Hereditary vitamin D resistant rickets (HVDRR) is a bone disorder characterized by a phenotype of rickets with onset at early stage of life with elevated alkaline phosphatase, hypocalcemia, hypophosphatemia, hyperparathyroidism and elevated levels of 1,25-dihydroxyvitamin D (calcitriol) as a consequence of the resistance of the vitamin D receptor (VDR). Vitamin D 22-31 vitamin D receptor Homo sapiens 341-359 31926093-1 2020 Background Hereditary vitamin D resistant rickets (HVDRR) is a bone disorder characterized by a phenotype of rickets with onset at early stage of life with elevated alkaline phosphatase, hypocalcemia, hypophosphatemia, hyperparathyroidism and elevated levels of 1,25-dihydroxyvitamin D (calcitriol) as a consequence of the resistance of the vitamin D receptor (VDR). Vitamin D 22-31 vitamin D receptor Homo sapiens 52-55 32049468-4 2020 In addition to the well-known role of vitamin D in calcium and phosphate homeostasis, the hormonally active vitamin D metabolite, 1,25-dihydroxyvitamin D3 (calcitriol), exerts potent effects on cellular differentiation and regulation of immune responses via binding to the vitamin D receptor present in most cells of the immune system. Vitamin D 108-117 vitamin D receptor Homo sapiens 273-291 32918214-6 2020 It seems probable that other factors such as ethnicity, phenotype, 25(OH)D plasma levels, and UV radiation exposure play a role as confounding factors and introduce heterogeneity.To conclude, there is some indication that VDR polymorphisms may modulate the risk of some cancer sites and in future studies VDR genetic variation should be integrated also with assessment of vitamin D status and stratified by ethnicity. Vitamin D 372-381 vitamin D receptor Homo sapiens 222-225 32051922-2 2020 It is widely recognized that the vitamin D receptor (VDR) and the enzymes that metabolize vitamin D are found in many cells, not just those involved with calcium and phosphate homeostasis. Vitamin D 33-42 vitamin D receptor Homo sapiens 53-56 31642155-5 2020 Vitamin D downstream signalling has also been checked in placenta (VDR, CYP27B1, Cathelicidin LL37) along with expression of inflammatory markers (S100A8, HMGB1, TLR2, pNF-kappaB) using Western blotting and immunohistochemistry. Vitamin D 0-9 vitamin D receptor Homo sapiens 67-70 32918226-2 2020 The active form of vitamin D, vitamin D3 or calcitriol, binds to the ligand-activated transcription factor vitamin D receptor (VDR) for genomic and non-genomic effects. Vitamin D 19-28 vitamin D receptor Homo sapiens 107-125 31942011-8 2020 In sum, our results show that vitamin D/VDR signaling induces miR-27a/b in oral lichen planus. Vitamin D 30-39 vitamin D receptor Homo sapiens 40-43 32918224-5 2020 These cells not only produce vitamin D but contain the enzymatic machinery to metabolize vitamin D to its active metabolite, 1,25(OH)2D, and express the receptor for this metabolite, the vitamin D receptor (VDR). Vitamin D 29-38 vitamin D receptor Homo sapiens 187-205 32918226-2 2020 The active form of vitamin D, vitamin D3 or calcitriol, binds to the ligand-activated transcription factor vitamin D receptor (VDR) for genomic and non-genomic effects. Vitamin D 19-28 vitamin D receptor Homo sapiens 127-130 32918224-5 2020 These cells not only produce vitamin D but contain the enzymatic machinery to metabolize vitamin D to its active metabolite, 1,25(OH)2D, and express the receptor for this metabolite, the vitamin D receptor (VDR). Vitamin D 29-38 vitamin D receptor Homo sapiens 207-210 32918224-5 2020 These cells not only produce vitamin D but contain the enzymatic machinery to metabolize vitamin D to its active metabolite, 1,25(OH)2D, and express the receptor for this metabolite, the vitamin D receptor (VDR). Vitamin D 89-98 vitamin D receptor Homo sapiens 187-205 32918224-5 2020 These cells not only produce vitamin D but contain the enzymatic machinery to metabolize vitamin D to its active metabolite, 1,25(OH)2D, and express the receptor for this metabolite, the vitamin D receptor (VDR). Vitamin D 89-98 vitamin D receptor Homo sapiens 207-210 31557081-0 2020 NOVEL VDR MUTATIONS IN PATIENTS WITH VITAMIN D-DEPENDENT RICKETS TYPE 2A: A MILD DISEASE PHENOTYPE CAUSED BY A NOVEL CANONICAL SPLICE-SITE MUTATION. Vitamin D 37-46 vitamin D receptor Homo sapiens 6-9 31312865-1 2020 This special issue article will focus on morphologic and functional roles of vitamin D in muscle, from strength to contraction to development and ageing and will characterise the controversy of VDR"s expression in skeletal muscle, central to our understanding of vitamin D"s effects on this tissue. Vitamin D 263-272 vitamin D receptor Homo sapiens 194-197 31006279-2 2020 The actions of the active form of vitamin D are mediated via the vitamin D receptor (VDR), which is expressed in numerous organs including placenta. Vitamin D 34-43 vitamin D receptor Homo sapiens 65-83 31006279-2 2020 The actions of the active form of vitamin D are mediated via the vitamin D receptor (VDR), which is expressed in numerous organs including placenta. Vitamin D 34-43 vitamin D receptor Homo sapiens 85-88 31972611-4 2020 We investigated the expression of miR-346 and its 2 target genes, the receptor of vitamin D (VDR), and the tumor necrosis factor-alpha (TNF-alpha), which are known to modulate carcinogenesis. Vitamin D 82-91 vitamin D receptor Homo sapiens 93-96 32504501-4 2020 PURPOSE OF REVIEW: This review summarizes the latest studies carried out to evaluate the primary mechanisms underlying the neuroprotective effect of vitamin D and its receptors (VDR) in the central nervous system. Vitamin D 149-158 vitamin D receptor Homo sapiens 178-181 31557081-1 2020 Objective: Vitamin D-dependent rickets type 2A (VDDR2A) is a rare autosomal recessive disorder caused by mutations in the vitamin D receptor gene (VDR), leading to end-organ resistance to 1,25-dihydroxyvitamin D3 (1,25[OH]2D3). Vitamin D 11-20 vitamin D receptor Homo sapiens 122-140 31557081-1 2020 Objective: Vitamin D-dependent rickets type 2A (VDDR2A) is a rare autosomal recessive disorder caused by mutations in the vitamin D receptor gene (VDR), leading to end-organ resistance to 1,25-dihydroxyvitamin D3 (1,25[OH]2D3). Vitamin D 11-20 vitamin D receptor Homo sapiens 147-150 32368685-1 2019 Introduction: The biological actions of vitamin D are mediated through vitamin D receptor (VDR). Vitamin D 40-49 vitamin D receptor Homo sapiens 71-89 31792684-3 2020 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the hormonally active form of vitamin D, is responsible for the biological actions of vitamin D which are mediated by the vitamin D receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 162-180 31792684-3 2020 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the hormonally active form of vitamin D, is responsible for the biological actions of vitamin D which are mediated by the vitamin D receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 182-185 31792684-3 2020 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the hormonally active form of vitamin D, is responsible for the biological actions of vitamin D which are mediated by the vitamin D receptor (VDR). Vitamin D 70-79 vitamin D receptor Homo sapiens 162-180 31792684-3 2020 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the hormonally active form of vitamin D, is responsible for the biological actions of vitamin D which are mediated by the vitamin D receptor (VDR). Vitamin D 70-79 vitamin D receptor Homo sapiens 182-185 31593305-13 2020 Several studies show that 1,25-dihydroxyvitamin D3 and vitamin D analogs (synthetic vitamin D-like compounds) suppress proliferation and migration in human VDR-expressing glioma cell lines. Vitamin D 40-49 vitamin D receptor Homo sapiens 156-159 31593305-13 2020 Several studies show that 1,25-dihydroxyvitamin D3 and vitamin D analogs (synthetic vitamin D-like compounds) suppress proliferation and migration in human VDR-expressing glioma cell lines. Vitamin D 55-64 vitamin D receptor Homo sapiens 156-159 32219739-8 2020 Another important dimension to be considered in the study of vitamin D and muscle fiber metabolism is associated with different expressions of the vitamin D receptor, which differs in muscle tissue, depending on age, gender, and pathology. Vitamin D 61-70 vitamin D receptor Homo sapiens 147-165 31892349-0 2019 Association between vitamin D plasma concentrations and VDR gene variants and the risk of premature birth. Vitamin D 20-29 vitamin D receptor Homo sapiens 56-59 31892349-2 2019 The effects of vitamin D are mediated by its receptor, which is encoded by the VDR gene. Vitamin D 15-24 vitamin D receptor Homo sapiens 79-82 31892349-13 2019 CONCLUSIONS: VDR variants contribute to variations in vitamin D concentrations and the increased risk of prematurity. Vitamin D 54-63 vitamin D receptor Homo sapiens 13-16 32289634-2 2020 The aim of this study was to determine whether 28 single nucleotide polymorphisms (SNPs) in six key vitamin D pathway genes (GC, DHCR7, CYP2 R1, CYP24 A1, CYP27 B1, VDR) were associated with differences in response to supplementation. Vitamin D 100-109 vitamin D receptor Homo sapiens 165-168 32368685-1 2019 Introduction: The biological actions of vitamin D are mediated through vitamin D receptor (VDR). Vitamin D 40-49 vitamin D receptor Homo sapiens 91-94 31618573-2 2019 In the present study, we dissect the complex biological activity of vitamin D by designing synthetic vitamin D3 analogs specific for VDR or SREBP pathway, i.e., a VDR activator that lacks SREBP inhibitory activity, or an SREBP inhibitor devoid of VDR activity. Vitamin D 68-77 vitamin D receptor Homo sapiens 133-136 31618573-2 2019 In the present study, we dissect the complex biological activity of vitamin D by designing synthetic vitamin D3 analogs specific for VDR or SREBP pathway, i.e., a VDR activator that lacks SREBP inhibitory activity, or an SREBP inhibitor devoid of VDR activity. Vitamin D 68-77 vitamin D receptor Homo sapiens 163-166 31618573-2 2019 In the present study, we dissect the complex biological activity of vitamin D by designing synthetic vitamin D3 analogs specific for VDR or SREBP pathway, i.e., a VDR activator that lacks SREBP inhibitory activity, or an SREBP inhibitor devoid of VDR activity. Vitamin D 68-77 vitamin D receptor Homo sapiens 163-166 31292859-3 2019 Recent evidence suggests vitamin D has a critical role in maintaining heart health through activation of the vitamin D receptor expressed in cardiomyocytes, and vitamin D deficiency may be implicated in the pathophysiology of HFrEF through activation of the renin-angiotensin system, impaired calcium handling, exaggerated inflammation, secondary hyperparathyroidism, pro-fibrotic properties, and proatherogenic potential. Vitamin D 25-34 vitamin D receptor Homo sapiens 109-127 31833904-13 2019 CONCLUSIONS: Vitamin D supplementation had no beneficial effect on anti-TB treatment, but it reduced the time to sputum culture conversion in participants with tt genotype of the TaqI vitamin D receptor gene polymorphism and improved the MDR TB sputum culture conversion rate. Vitamin D 13-22 vitamin D receptor Homo sapiens 184-202 31866999-8 2019 In addition, vitamin D negatively regulates the NLRP3 inflammasome via VDR signaling to effectively inhibit IL-1beta secretion. Vitamin D 13-22 vitamin D receptor Homo sapiens 71-74 31731733-9 2019 Moreover, the studies for an adopted vitamin D supplementation due to breast cancer focality type must be enlarged to fully comprehend the remarkable and interesting role played by the vitamin D receptor. Vitamin D 37-46 vitamin D receptor Homo sapiens 185-203 31690667-3 2019 As patients with melanoma commonly avoid sun exposure, and consequent vitamin D deficiency might worsen outcomes, we interrogated 703 primary melanoma transcriptomes to understand the role of vitamin D-VDR signaling and replicated the findings in The Cancer Genome Atlas metastases. Vitamin D 192-201 vitamin D receptor Homo sapiens 202-205 31690667-8 2019 Vitamin D deficiency (<25 nmol/L ~ 10 ng/mL) shortened survival in primary melanoma in a VDR-dependent manner. Vitamin D 0-9 vitamin D receptor Homo sapiens 89-92 31690667-9 2019 In vitro functional validation studies showed that elevated vitamin D-VDR signaling inhibited Wnt/beta-catenin signaling genes. Vitamin D 60-69 vitamin D receptor Homo sapiens 70-73 31589177-6 2019 Genetic and experimental evidence suggests that vitamin D and the vitamin D receptor (VDR) may influence the gut microbiome in health and disease. Vitamin D 66-75 vitamin D receptor Homo sapiens 86-89 31725784-5 2019 The mineral absorption pathway genes, HMOX1 and VDR are involved in iron metabolism and response to vitamin D, respectively. Vitamin D 100-109 vitamin D receptor Homo sapiens 48-51 31651513-16 2019 VD may regulate the formation and differentiation of adipocytes through the VDR and PPARgamma pathways and participate in the occurrence of GDM. Vitamin D 0-2 vitamin D receptor Homo sapiens 76-79 31867158-6 2019 Activated VDR forms a heterodimer with retinoid X receptor alpha (RXRalpha), recruits co-activators, translocates to the cell nucleus, binds to the specific vitamin D responsive elements (VDRE), and activates the gene transcription. Vitamin D 157-166 vitamin D receptor Homo sapiens 10-13 31640823-1 2020 Studies show that vitamin D (vit-D) (25(OH)D); the bioactive metabolite (1,25(OH)2D3) and vit-D receptors (VDR: vit-D receptor; PDIA3: Protein-Disulphide-Isomerase, family A member 3) are expressed throughout the brain, particularly in regions pivotal to learning and memory. Vitamin D 18-27 vitamin D receptor Homo sapiens 107-110 31719947-6 2019 Logistic regression analyses were performed to detect an association between allergic asthma status and the interaction of the VDR SNP and serum vitamin D concentration in the case-control samples. Vitamin D 145-154 vitamin D receptor Homo sapiens 127-130 31640823-1 2020 Studies show that vitamin D (vit-D) (25(OH)D); the bioactive metabolite (1,25(OH)2D3) and vit-D receptors (VDR: vit-D receptor; PDIA3: Protein-Disulphide-Isomerase, family A member 3) are expressed throughout the brain, particularly in regions pivotal to learning and memory. Vitamin D 90-95 vitamin D receptor Homo sapiens 107-110 31115927-1 2019 Vitamin D (Vit D) increases calcium absorption in the intestine after binding to the Vit D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 85-99 31640823-1 2020 Studies show that vitamin D (vit-D) (25(OH)D); the bioactive metabolite (1,25(OH)2D3) and vit-D receptors (VDR: vit-D receptor; PDIA3: Protein-Disulphide-Isomerase, family A member 3) are expressed throughout the brain, particularly in regions pivotal to learning and memory. Vitamin D 90-95 vitamin D receptor Homo sapiens 107-110 31636627-1 2019 Vitamin D, together with its nuclear receptor (VDR), plays an important role in modulating the immune response, decreasing the inflammatory process. Vitamin D 0-9 vitamin D receptor Homo sapiens 47-50 31415247-2 2019 In patients with thrombotic state and vitamin D deficiency, vitamin D analogs and vitamin D receptor activators have been determined as adjunctive anticoagulant treatment in previous studies. Vitamin D 38-47 vitamin D receptor Homo sapiens 82-100 31649297-0 2019 Association of Fok1 VDR polymorphism with Vitamin D and its associated molecules in pulmonary tuberculosis patients and their household contacts. Vitamin D 42-51 vitamin D receptor Homo sapiens 20-23 31115927-1 2019 Vitamin D (Vit D) increases calcium absorption in the intestine after binding to the Vit D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 101-104 31278171-1 2019 INTRODUCTION: Vitamin D is best known for its role in bone health; however, the discovery of the vitamin D receptor and the expression of the gene encoding the vitamin D 1alpha-hydroxylase (CYP27B1) enzyme in a wide variety of tissues including immune cells and respiratory epithelium has led to the discovery of potential roles for vitamin D in the prevention of acute wheeze. Vitamin D 14-23 vitamin D receptor Homo sapiens 97-115 31255688-14 2019 Higher levels of Vitamin D along with VDR and iNOS expression in household contacts as compared to active TB patients suggest vitamin D might have a protective role against TB plausibly decreasing disease susceptibility. Vitamin D 126-135 vitamin D receptor Homo sapiens 38-41 31359379-8 2019 Our findings for the first time indicated that there is a strong association between vitamin D deficiency, lipid profile and the VDR rs1544410G>A and rs7T41>G VDBP genes polymorphisms. Vitamin D 85-94 vitamin D receptor Homo sapiens 129-132 31326626-0 2019 Differential response of lung cancer cell lines to vitamin D derivatives depending on EGFR, KRAS, p53 mutation status and VDR polymorphism. Vitamin D 51-60 vitamin D receptor Homo sapiens 122-125 31326626-5 2019 The goal of our study was to establish if cells differing in EGFR, KRAS, p53 mutation status and VDR polymorphism were sensitive to antiproliferative activity of selected vitamin D derivatives (VDDs). Vitamin D 171-180 vitamin D receptor Homo sapiens 97-100 31559105-4 2019 In the past few years a large body of evidence has been assembled that attributes an important role in hepatic aberrant fat accumulation, inflammation and fibrosis, to the vitamin D/vitamin D receptor (VD/VDR) axis, showing a strong association between hypovitaminosis D and the diagnosis of NAFLD. Vitamin D 172-181 vitamin D receptor Homo sapiens 205-208 31559105-4 2019 In the past few years a large body of evidence has been assembled that attributes an important role in hepatic aberrant fat accumulation, inflammation and fibrosis, to the vitamin D/vitamin D receptor (VD/VDR) axis, showing a strong association between hypovitaminosis D and the diagnosis of NAFLD. Vitamin D 182-191 vitamin D receptor Homo sapiens 205-208 31583252-5 2019 Multiplex TaqMan genotyping was used to determine the distribution of eight candidate SNPs in genes of DHCR7, CYP2R1, CYP27B1, CYP24A1, and VDR, which are key genes in the vitamin D metabolic pathway, in diabetic patients. Vitamin D 172-181 vitamin D receptor Homo sapiens 140-143 31508781-14 2019 Studies investigating the roles of vitamin D and LL-37 in the immune response and their associations with VDR polymorphisms and disease susceptibility are necessary. Vitamin D 35-44 vitamin D receptor Homo sapiens 106-109 31701079-9 2019 Our results suggest an upregulation of the VDR-1,25(OH)2D complex bioavailability in GDM-d placentas, possibly reflecting a compensatory mechanism aiming to ensure that vitamin D can exert its genomic and nongenomic effects in the target cells of the placental-fetal unit. Vitamin D 169-178 vitamin D receptor Homo sapiens 43-46 31126722-9 2019 AD and/or psychosis-related genes were enriched in the list of genes most perturbed by vitamin D, specifically genes involved in the regulation of calcium signaling downstream of the vitamin D receptor. Vitamin D 87-96 vitamin D receptor Homo sapiens 183-201 31272909-2 2019 It is suggested that antitumour effect of vitamin D depends on vitamin D-receptor (VDR) expression. Vitamin D 42-51 vitamin D receptor Homo sapiens 63-81 31272909-2 2019 It is suggested that antitumour effect of vitamin D depends on vitamin D-receptor (VDR) expression. Vitamin D 42-51 vitamin D receptor Homo sapiens 83-86 30887870-4 2019 Our aim was to identify the association of specific single nucleotide variants in the PTPN22, VDR, KL, and CYP27B1 genes and vitamin D-metabolism, heart malformation, renal malformation, thyroiditis, and low-BMD in 61 Mexican TS-patients. Vitamin D 125-134 vitamin D receptor Homo sapiens 94-97 31261027-10 2019 However, Overexpression of VDR and vitamin D treatment could induce the cell survival and alleviate the FoxO1-induced cell apoptosis, furthermore, vitamin D treatment or silencing of FoxO1 gene could reverse the ROS-induced cell apoptosis. Vitamin D 147-156 vitamin D receptor Homo sapiens 27-30 30887870-8 2019 In addition, we identified gene-gene interactions between variants in genes KL, CYP27B1 and VDR related to vitamin D-metabolism and low-BMD in TS-patients. Vitamin D 107-116 vitamin D receptor Homo sapiens 92-95 31591986-1 2019 BACKGROUND: The proposed role of Vitamin D Receptor (VDR) in various cancers underscores the importance of vitamin D compounds as a novel therapeutic agent in the prevention of occurrence and progression of cancer. Vitamin D 107-116 vitamin D receptor Homo sapiens 33-51 30321335-2 2019 Vitamin D is the precursor of 25-hydroxyvitamin D and other metabolites, including 1,25(OH)2D, the ligand for the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 114-132 31591986-1 2019 BACKGROUND: The proposed role of Vitamin D Receptor (VDR) in various cancers underscores the importance of vitamin D compounds as a novel therapeutic agent in the prevention of occurrence and progression of cancer. Vitamin D 107-116 vitamin D receptor Homo sapiens 53-56 31455010-0 2019 Investigating the Role of VDR and Megalin in Semi-Selectivity of Side-Chain Modified 19-nor Analogs of Vitamin D. Vitamin D 103-112 vitamin D receptor Homo sapiens 26-29 31300316-1 2019 Lithocholic acid (2) was identified as the second endogenous ligand of vitamin D receptor (VDR), though its binding affinity to VDR and its vitamin D activity are very weak compared to those of the active metabolite of vitamin D3, 1alpha,25-dihydroxyvitamin D3 (1). Vitamin D 71-80 vitamin D receptor Homo sapiens 91-94 31395070-10 2019 CONCLUSIONS: Findings of this study showed that genetic variation in the VDR gene was associated with changes in cardio-metabolic parameters in breast cancer survivors, supplemented with vitamin D3, results could provide a novel insight into better understanding of which subset of individuals benefit most from normalization of vitamin D status. Vitamin D 187-196 vitamin D receptor Homo sapiens 73-76 31534963-0 2019 Relationship between Serum Vitamin D and Calcium Levels and Vitamin D Receptor Gene Polymorphisms in Colorectal Cancer. Vitamin D 27-36 vitamin D receptor Homo sapiens 60-78 31534963-2 2019 The biological action of vitamin D and its metabolites is mediated by the transcription factor vitamin D receptor (VDR). Vitamin D 25-34 vitamin D receptor Homo sapiens 95-113 31534963-2 2019 The biological action of vitamin D and its metabolites is mediated by the transcription factor vitamin D receptor (VDR). Vitamin D 25-34 vitamin D receptor Homo sapiens 115-118 31534963-4 2019 The aim of the current study was to assess the relationship between serum vitamin D metabolite and calcium levels with VDR polymorphisms in normal and colorectal cancer (CRC) patients. Vitamin D 74-83 vitamin D receptor Homo sapiens 119-122 31534963-7 2019 Results: The homozygous genotype (aa) of the ApaI VDR polymorphism (rs7975232) was found to correlate with total serum vitamin D levels of CRC patients, while the heterozygous (Tt) TaqI VDR polymorphism (rs731236) was associated with serum calcium levels. Vitamin D 119-128 vitamin D receptor Homo sapiens 50-53 30916559-5 2019 The nearly 150 crystal structures of VDR"s ligand-binding domain with various vitamin D compounds allow a detailed molecular understanding of their action. Vitamin D 78-87 vitamin D receptor Homo sapiens 37-40 31043390-0 2019 Vitamin D Modifies the Incidence of Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation Depending on the Vitamin D Receptor (VDR) Polymorphisms. Vitamin D 0-9 vitamin D receptor Homo sapiens 122-140 31043390-0 2019 Vitamin D Modifies the Incidence of Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation Depending on the Vitamin D Receptor (VDR) Polymorphisms. Vitamin D 0-9 vitamin D receptor Homo sapiens 142-145 30321335-2 2019 Vitamin D is the precursor of 25-hydroxyvitamin D and other metabolites, including 1,25(OH)2D, the ligand for the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 134-137 31358030-3 2019 Vitamin D exerts its functions through the vitamin D receptor (VDR), and the aim of the current study was to investigate if the expression of VDR in invasive breast tumors is associated with breast cancer prognosis. Vitamin D 0-9 vitamin D receptor Homo sapiens 43-61 31252402-6 2019 RNA-sequencing revealed a Vitamin D dose-response gene signature enriched with a higher number of VDR-responsive elements (VDREs) per gene. Vitamin D 26-35 vitamin D receptor Homo sapiens 98-101 31358030-3 2019 Vitamin D exerts its functions through the vitamin D receptor (VDR), and the aim of the current study was to investigate if the expression of VDR in invasive breast tumors is associated with breast cancer prognosis. Vitamin D 0-9 vitamin D receptor Homo sapiens 63-66 31358030-3 2019 Vitamin D exerts its functions through the vitamin D receptor (VDR), and the aim of the current study was to investigate if the expression of VDR in invasive breast tumors is associated with breast cancer prognosis. Vitamin D 0-9 vitamin D receptor Homo sapiens 142-145 31070844-1 2019 OBJECTIVES: This study evaluated the associations between single-nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) gene, maternal vitamin D concentration, and gestational outcomes. Vitamin D 104-113 vitamin D receptor Homo sapiens 124-127 30929318-4 2019 OBJECTIVES: The aim of this study was to investigate the association of the TaqI polymorphism (rs731236, c.1056T >C) in the VDR gene with serum vitamin D concentration and bone mineral density (BMD) in patients with IBD. Vitamin D 147-156 vitamin D receptor Homo sapiens 127-130 31070844-9 2019 CONCLUSIONS: The VDR gene is an important genetic predictor of a higher concentration of vitamin D during gestation, low birth weight, and decreasing duration of gestation. Vitamin D 89-98 vitamin D receptor Homo sapiens 17-20 31029431-14 2019 CONCLUSION(S): The VDR is expressed throughout the organs of reproduction, suggesting a role for vitamin D in reproduction. Vitamin D 97-106 vitamin D receptor Homo sapiens 19-22 31344716-1 2019 OBJECTIVE: To evaluate the relationship between vitamin D receptor (VDR) gene polymorphism (FokI [rs10735810]) and serum vitamin D concentration in gestational diabetes mellitus (GDM). Vitamin D 49-58 vitamin D receptor Homo sapiens 69-72 31134092-5 2019 The exact association between Vitamin D deficiency and chronic disease conditions remains unclear; however, studies have focused on the mechanism of Vitamin D regulation by assessing the role of the Vitamin D associated genes/proteins such as VDR (Vitamin D receptor), VDBP (Vitamin D Binding protein), CYP27B1 as these are integral parts of the Vitamin D signaling pathway. Vitamin D 149-158 vitamin D receptor Homo sapiens 243-246 30308088-4 2019 In the process we explore the mechanisms postulated to explain the action of these vitamin D analogues including action through the vitamin D receptor, action through other receptors e.g. FAM57B2 and dual action on transcriptional processes. Vitamin D 83-92 vitamin D receptor Homo sapiens 132-150 30923017-11 2019 In conclusion, we suggest that both VDR and CaSR might be useful as molecular markers for predicting treatment outcomes and identifying the CRC patient subgroups who might benefit from 5-FU-based chemotherapy combined with vitamin D analog. Vitamin D 223-232 vitamin D receptor Homo sapiens 36-39 30977086-0 2019 Strong association between VDR FokI (rs2228570) gene variant and serum vitamin D levels in Turkish Cypriots. Vitamin D 71-80 vitamin D receptor Homo sapiens 27-30 30977086-5 2019 In this study the four most common VDR polymorphisms (rs1544410 (BsmI), rs731236 (TaqI), rs7975232 (ApaI) and rs2228570 (FokI)) are investigated in a cohort of Turkish Cypriots and aimed to detect any possible links between low serum vitamin D levels and these variants. Vitamin D 234-243 vitamin D receptor Homo sapiens 35-38 31134092-5 2019 The exact association between Vitamin D deficiency and chronic disease conditions remains unclear; however, studies have focused on the mechanism of Vitamin D regulation by assessing the role of the Vitamin D associated genes/proteins such as VDR (Vitamin D receptor), VDBP (Vitamin D Binding protein), CYP27B1 as these are integral parts of the Vitamin D signaling pathway. Vitamin D 149-158 vitamin D receptor Homo sapiens 243-246 31134092-5 2019 The exact association between Vitamin D deficiency and chronic disease conditions remains unclear; however, studies have focused on the mechanism of Vitamin D regulation by assessing the role of the Vitamin D associated genes/proteins such as VDR (Vitamin D receptor), VDBP (Vitamin D Binding protein), CYP27B1 as these are integral parts of the Vitamin D signaling pathway. Vitamin D 149-158 vitamin D receptor Homo sapiens 243-246 31141481-1 2019 Background Vitamin D resistant rickets (HVDRR), is a rare autosomal recessive disorder caused by vitamin D receptor (VDR) gene mutations. Vitamin D 11-20 vitamin D receptor Homo sapiens 97-115 31141481-1 2019 Background Vitamin D resistant rickets (HVDRR), is a rare autosomal recessive disorder caused by vitamin D receptor (VDR) gene mutations. Vitamin D 11-20 vitamin D receptor Homo sapiens 41-44 30903715-10 2019 In vitro analysis showed that adding different concentrations of active vitamin D increased the Treg/Th17 ratio, also the mRNA levels of the vitamin D receptor and the metabolic enzyme CYP24A1 increased significantly. Vitamin D 72-81 vitamin D receptor Homo sapiens 141-159 31028080-6 2019 Analysis of the VDR cistrome in RWPE1 prostate epithelial cells revealed vitamin D-mediated regulation of multiple cancer-relevant pathways. Vitamin D 73-82 vitamin D receptor Homo sapiens 16-19 30905091-1 2019 BACKGROUND: Vitamin D, a hormone that acts through the nuclear vitamin D receptor (VDR), upregulates antitumorigenic microRNA in prostate epithelium. Vitamin D 12-21 vitamin D receptor Homo sapiens 63-81 30905091-1 2019 BACKGROUND: Vitamin D, a hormone that acts through the nuclear vitamin D receptor (VDR), upregulates antitumorigenic microRNA in prostate epithelium. Vitamin D 12-21 vitamin D receptor Homo sapiens 83-86 30905091-5 2019 VDR chromatin immunoprecipitation-sequencing was performed to identify vitamin D genomic targets in primary prostate epithelial cells. Vitamin D 71-80 vitamin D receptor Homo sapiens 0-3 31134092-6 2019 VDR is known to regulate the expression of more than 200 genes across a wide array of tissues in the human body and may play a role in controlling the Vitamin D levels. Vitamin D 151-160 vitamin D receptor Homo sapiens 0-3 31134092-7 2019 Moreover, reduced Vitamin D level and downregulation of VDR have been linked to gut dysbiosis, highlighting an intriguing role for the gut microbiome in the Vitamin D metabolism. Vitamin D 157-166 vitamin D receptor Homo sapiens 56-59 31134092-5 2019 The exact association between Vitamin D deficiency and chronic disease conditions remains unclear; however, studies have focused on the mechanism of Vitamin D regulation by assessing the role of the Vitamin D associated genes/proteins such as VDR (Vitamin D receptor), VDBP (Vitamin D Binding protein), CYP27B1 as these are integral parts of the Vitamin D signaling pathway. Vitamin D 149-158 vitamin D receptor Homo sapiens 243-246 30730049-2 2019 The vitamin D receptor (VDR) has a crucial role in the pathogenesis of this disease because it mediates the functions of vitamin D in the immune system. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 31205465-0 2019 Arsenic Trioxide in Synergy with Vitamin D Rescues the Defective VDR-PPAR-gamma Functional Module of Autophagy in Rheumatoid Arthritis. Vitamin D 33-42 vitamin D receptor Homo sapiens 65-68 31039170-1 2019 BACKGROUND: Vitamin D may play a role in skeletal muscle because of the discovery of VDR in skeletal muscle. Vitamin D 12-21 vitamin D receptor Homo sapiens 85-88 31001917-2 2019 We sought to examine associations between genetic variants in VDR and additional genes from vitamin D biosynthesis and pathway targets (EGFR, UGT1A, UGT2A1/2, UGT2B, CYP3A4/5, CYP2R1, CYP27B1, CYP24A1, CYP11A1, and GC). Vitamin D 92-101 vitamin D receptor Homo sapiens 62-65 30714636-4 2019 Vitamin D exerts its effect through vitamin D receptor and variants in vitamin D receptor (VDR) gene are shown to affect vitamin D signaling. Vitamin D 0-9 vitamin D receptor Homo sapiens 36-54 30714636-4 2019 Vitamin D exerts its effect through vitamin D receptor and variants in vitamin D receptor (VDR) gene are shown to affect vitamin D signaling. Vitamin D 0-9 vitamin D receptor Homo sapiens 71-89 30714636-4 2019 Vitamin D exerts its effect through vitamin D receptor and variants in vitamin D receptor (VDR) gene are shown to affect vitamin D signaling. Vitamin D 0-9 vitamin D receptor Homo sapiens 91-94 30714636-12 2019 In addition, combined analysis of vitamin D levels and VDR mutants revealed association of vitamin D deficiencies and VDR mutants with chronic heart failure. Vitamin D 91-100 vitamin D receptor Homo sapiens 55-58 30714636-12 2019 In addition, combined analysis of vitamin D levels and VDR mutants revealed association of vitamin D deficiencies and VDR mutants with chronic heart failure. Vitamin D 91-100 vitamin D receptor Homo sapiens 118-121 30944611-4 2019 The biologically active form of vitamin D/1,25-dihydroxyvitamin D3 acts by binding to a intranuclear receptor; vitamin D receptor (VDR). Vitamin D 32-41 vitamin D receptor Homo sapiens 111-129 30944611-4 2019 The biologically active form of vitamin D/1,25-dihydroxyvitamin D3 acts by binding to a intranuclear receptor; vitamin D receptor (VDR). Vitamin D 32-41 vitamin D receptor Homo sapiens 131-134 30890957-1 2019 The molecular basis of vitamin D signaling implies that the metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) of the secosteroid vitamin D3 activates the transcription factor vitamin D receptor (VDR), which in turn modulates the expression of hundreds of primary vitamin D target genes. Vitamin D 23-32 vitamin D receptor Homo sapiens 180-198 30718230-5 2019 Interfering VDR signals, such as low vitamin D diet and VDR deficiency in donor cells as well as macrophage depletion prevented myelofibrosis in this model. Vitamin D 37-46 vitamin D receptor Homo sapiens 12-15 30975133-1 2019 BACKGROUND: Evidence shows that low serum vitamin D concentrations account for an increased risk of obesity by inducing vitamin D receptor (VDR) hypofunction. Vitamin D 42-51 vitamin D receptor Homo sapiens 120-138 30975133-1 2019 BACKGROUND: Evidence shows that low serum vitamin D concentrations account for an increased risk of obesity by inducing vitamin D receptor (VDR) hypofunction. Vitamin D 42-51 vitamin D receptor Homo sapiens 140-143 30890957-3 2019 Moreover, the nearly ubiquitous expression of VDR enabled vitamin D to acquire additional physiological functions, such as the support of the innate immune system in its defense against microbes. Vitamin D 58-67 vitamin D receptor Homo sapiens 46-49 31035488-1 2019 BACKGROUND: Epidemiological studies have suggested a survival benefit for hemodialysis patients on paricalcitol or calcitriol, but nutritional vitamin D supplementation of patients already on vitamin D receptor (VDR) activators is controversial. Vitamin D 143-152 vitamin D receptor Homo sapiens 192-210 30959822-1 2019 The vitamin D receptor (VDR) mediates vitamin D actions beyond bone health. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 30959822-8 2019 Cell proliferation assays corroborated this conjectured oppositional basal VDR activity, indicating that precise 1,25D dosage in target tissues might be essential for modulating vitamin D actions in human health. Vitamin D 178-187 vitamin D receptor Homo sapiens 75-78 30969078-2 2019 In our study we aimed to investigate the correlations among urothelial type bladder cancer polymorphisms, ApaI, BsmI, FokI, and TaqI, prevalently observed in the vitamin D receptor (VDR) gene and plasma vitamin D levels in a Turkish population. Vitamin D 162-171 vitamin D receptor Homo sapiens 182-185 30830277-2 2019 It focuses on several aspects related to cellular and molecular physiology such as VDR as the trigger point of vitamin D action, oxidative stress as a consequence of vitamin D deficiency. Vitamin D 111-120 vitamin D receptor Homo sapiens 83-86 30830277-10 2019 CONCLUSION: Based on the current knowledge we propose that vitamin D deficiency results from the loss of VDR function and it could be partly responsible for the development of neurodegenerative diseases in human beings. Vitamin D 59-68 vitamin D receptor Homo sapiens 105-108 31259360-1 2019 Vitamin D exerts an immuno-modulatory activity on several immune system cells through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 90-108 31259360-1 2019 Vitamin D exerts an immuno-modulatory activity on several immune system cells through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 110-113 30721418-1 2019 There is a significant association exists between vitamin D deficiencies, low respiratory tract infections, and certain types of VDR gene polymorphism. Vitamin D 50-59 vitamin D receptor Homo sapiens 129-132 30721418-2 2019 Various studies are being conducted to prove any such link between the different clinical conditions due to disturbed vitamin D regulation and VDR gene polymorphisms. Vitamin D 118-127 vitamin D receptor Homo sapiens 143-146 30529188-3 2019 Another important aspect to be considered in the study of vitamin D and muscle fiber metabolism is related to different expression of vitamin D receptor (VDR), which varies in muscle tissue depending on age, sex, and pathology. Vitamin D 58-67 vitamin D receptor Homo sapiens 134-152 30529188-3 2019 Another important aspect to be considered in the study of vitamin D and muscle fiber metabolism is related to different expression of vitamin D receptor (VDR), which varies in muscle tissue depending on age, sex, and pathology. Vitamin D 58-67 vitamin D receptor Homo sapiens 154-157 30659895-8 2019 RESULTS: VitD administration prevented bleomycin-induced lung fibrosis, as assessed by reductions in hydroxyproline levels, mRNA levels of col1a1, col3a1 and a-SMA (1.4-, 3.1-, 2.25-, 2.5-fold, respectively) and Masson Trichrome staining compared to the untreated group and these changes were associated with restoration of the bleomycin-induced downregulation of vitamin D-receptor (Vdr) mRNA levels. Vitamin D 9-13 vitamin D receptor Homo sapiens 364-382 30659895-8 2019 RESULTS: VitD administration prevented bleomycin-induced lung fibrosis, as assessed by reductions in hydroxyproline levels, mRNA levels of col1a1, col3a1 and a-SMA (1.4-, 3.1-, 2.25-, 2.5-fold, respectively) and Masson Trichrome staining compared to the untreated group and these changes were associated with restoration of the bleomycin-induced downregulation of vitamin D-receptor (Vdr) mRNA levels. Vitamin D 9-13 vitamin D receptor Homo sapiens 384-387 30976148-1 2019 Purpose: To assess age related manifestations of the femur and tibia in patients with vitamin D-resistant rickets (VDR) and explore causes for recurrent deformity using imaging modalities. Vitamin D 86-95 vitamin D receptor Homo sapiens 115-118 30941131-0 2019 The Association Between Vitamin D and Multiple Sclerosis Risk: 1,25(OH)2D3 Induces Super-Enhancers Bound by VDR. Vitamin D 24-33 vitamin D receptor Homo sapiens 108-111 31011579-2 2019 Biologically active form 1, 25(OH)2D3 of vitamin D can only exert its action after binding its definite vitamin D receptor encoded by VDR gene. Vitamin D 41-50 vitamin D receptor Homo sapiens 104-122 31011579-2 2019 Biologically active form 1, 25(OH)2D3 of vitamin D can only exert its action after binding its definite vitamin D receptor encoded by VDR gene. Vitamin D 41-50 vitamin D receptor Homo sapiens 134-137 31011579-13 2019 In conclusion, serum vitamin D level may be normal among arthritis patients but polymorphism on VDR gene restricts vitamin D to perform its anti-inflammatory function by altering the 1, 25(OH)2 D3 binding sites. Vitamin D 21-30 vitamin D receptor Homo sapiens 96-99 31011579-13 2019 In conclusion, serum vitamin D level may be normal among arthritis patients but polymorphism on VDR gene restricts vitamin D to perform its anti-inflammatory function by altering the 1, 25(OH)2 D3 binding sites. Vitamin D 115-124 vitamin D receptor Homo sapiens 96-99 30845908-3 2019 Vitamin D has been shown to exert its effects via a nuclear vitamin D receptor (VDR) and therefore, VDR gene may be considered a candidate for T1DM susceptibility. Vitamin D 0-9 vitamin D receptor Homo sapiens 60-78 30845908-3 2019 Vitamin D has been shown to exert its effects via a nuclear vitamin D receptor (VDR) and therefore, VDR gene may be considered a candidate for T1DM susceptibility. Vitamin D 0-9 vitamin D receptor Homo sapiens 80-83 30845908-3 2019 Vitamin D has been shown to exert its effects via a nuclear vitamin D receptor (VDR) and therefore, VDR gene may be considered a candidate for T1DM susceptibility. Vitamin D 0-9 vitamin D receptor Homo sapiens 100-103 30890957-1 2019 The molecular basis of vitamin D signaling implies that the metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) of the secosteroid vitamin D3 activates the transcription factor vitamin D receptor (VDR), which in turn modulates the expression of hundreds of primary vitamin D target genes. Vitamin D 23-32 vitamin D receptor Homo sapiens 200-203 30890957-1 2019 The molecular basis of vitamin D signaling implies that the metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) of the secosteroid vitamin D3 activates the transcription factor vitamin D receptor (VDR), which in turn modulates the expression of hundreds of primary vitamin D target genes. Vitamin D 90-99 vitamin D receptor Homo sapiens 180-198 30890957-1 2019 The molecular basis of vitamin D signaling implies that the metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) of the secosteroid vitamin D3 activates the transcription factor vitamin D receptor (VDR), which in turn modulates the expression of hundreds of primary vitamin D target genes. Vitamin D 90-99 vitamin D receptor Homo sapiens 200-203 30890957-2 2019 Since the evolutionary role of nuclear receptors, such as VDR, was the regulation of cellular metabolism, the control of calcium metabolism became the primary function of vitamin D and its receptor. Vitamin D 171-180 vitamin D receptor Homo sapiens 58-61 30465855-2 2019 Here we report a novel mechanism of action of TGF-beta that promotes the counteracting activity of vitamin D; in two models of human epithelial-mesenchymal EMT transition we demonstrated for the first time that TGF-beta strongly induced the expression of vitamin D receptor (VDR) and that 1,25(OH)2D3 was able to contrast the TGF-beta-driven EMT transition by transcriptional modulation. Vitamin D 99-108 vitamin D receptor Homo sapiens 255-273 30832722-3 2019 This study was designed to examine the effects on vitamin D supplementation on serum levels of vitamin D receptor (VDR), fibrogenic factors, and fibrogenic microRNAs (MiR) in NAFLD patients. Vitamin D 50-59 vitamin D receptor Homo sapiens 95-113 30832722-3 2019 This study was designed to examine the effects on vitamin D supplementation on serum levels of vitamin D receptor (VDR), fibrogenic factors, and fibrogenic microRNAs (MiR) in NAFLD patients. Vitamin D 50-59 vitamin D receptor Homo sapiens 115-118 30832722-9 2019 DISCUSSION: This is the first randomized controlled trial that will determine the effect of vitamin D supplementation on serum levels of VDR, fibrogenic factors, and fibrogenic MiRs in NAFLD patients. Vitamin D 92-101 vitamin D receptor Homo sapiens 137-140 30984586-1 2019 Background: Vitamin D has stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells. Vitamin D 12-21 vitamin D receptor Homo sapiens 105-123 30984586-1 2019 Background: Vitamin D has stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells. Vitamin D 12-21 vitamin D receptor Homo sapiens 125-128 30984586-13 2019 Conclusion: The single nucleotide gene polymorphisms of various VDR genes as found in the cases might lead to vitamin D deficiency, due to VDR dysfunction, which in turn could increase the susceptibility to develop vitiligo. Vitamin D 110-119 vitamin D receptor Homo sapiens 64-67 30983779-1 2019 Background: Vitamin D, an important hormone required by the body, exerts its biological effects through Vitamin D receptors (VDRs) present on target cells. Vitamin D 12-21 vitamin D receptor Homo sapiens 104-123 30983779-15 2019 Conclusions: The study determined Vitamin D Receptors (VDR) in PDL tissue after supplementation of Vitamin D. Vitamin D 34-43 vitamin D receptor Homo sapiens 55-58 30465855-2 2019 Here we report a novel mechanism of action of TGF-beta that promotes the counteracting activity of vitamin D; in two models of human epithelial-mesenchymal EMT transition we demonstrated for the first time that TGF-beta strongly induced the expression of vitamin D receptor (VDR) and that 1,25(OH)2D3 was able to contrast the TGF-beta-driven EMT transition by transcriptional modulation. Vitamin D 99-108 vitamin D receptor Homo sapiens 275-278 30399574-2 2019 Vitamin D executes its functions by interacting with the vitamin D receptor (VDR), both in healthy and diseased individuals, including oral cancer. Vitamin D 0-9 vitamin D receptor Homo sapiens 57-75 30606768-10 2019 Collectively, these data show that the VDR and FBW7 are mutual cofactors, and provide a mechanistic basis for the cancer-preventive actions of vitamin D. Vitamin D 143-152 vitamin D receptor Homo sapiens 39-42 30606768-11 2019 IMPLICATIONS: The key findings show that the VDR and the E3 ligase FBW7 regulate each other"s functions in transcriptional regulation and control of protein turnover, respectively, and provide a molecular basis for cancer-preventive actions of vitamin D.Visual Overview: http://mcr.aacrjournals.org/content/17/3/709/F1.large.jpg. Vitamin D 244-253 vitamin D receptor Homo sapiens 45-48 30287151-3 2019 Vitamin D exerts its pharmacological effects primarily via vitamin D receptor, whose activation inhibits the renin-angiotensin system, a key culprit for DN under hyperglycemia. Vitamin D 0-9 vitamin D receptor Homo sapiens 59-77 30278216-2 2019 Since these physiological actions caused by active vitamin D are triggered by the specific interaction between the vitamin D receptor (VDR) and active vitamin D, many types of compounds have been developed as potent ligands against VDR. Vitamin D 51-60 vitamin D receptor Homo sapiens 115-133 30278216-2 2019 Since these physiological actions caused by active vitamin D are triggered by the specific interaction between the vitamin D receptor (VDR) and active vitamin D, many types of compounds have been developed as potent ligands against VDR. Vitamin D 51-60 vitamin D receptor Homo sapiens 135-138 30278216-2 2019 Since these physiological actions caused by active vitamin D are triggered by the specific interaction between the vitamin D receptor (VDR) and active vitamin D, many types of compounds have been developed as potent ligands against VDR. Vitamin D 51-60 vitamin D receptor Homo sapiens 232-235 30278216-2 2019 Since these physiological actions caused by active vitamin D are triggered by the specific interaction between the vitamin D receptor (VDR) and active vitamin D, many types of compounds have been developed as potent ligands against VDR. Vitamin D 115-124 vitamin D receptor Homo sapiens 135-138 30278216-2 2019 Since these physiological actions caused by active vitamin D are triggered by the specific interaction between the vitamin D receptor (VDR) and active vitamin D, many types of compounds have been developed as potent ligands against VDR. Vitamin D 115-124 vitamin D receptor Homo sapiens 232-235 30678432-2 2019 Vitamin D has been hypothesized to lower the risk of breast cancer via the nuclearvitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 102-105 30399574-2 2019 Vitamin D executes its functions by interacting with the vitamin D receptor (VDR), both in healthy and diseased individuals, including oral cancer. Vitamin D 0-9 vitamin D receptor Homo sapiens 77-80 31257315-1 2019 To develop potent ligands for the vitamin D receptor (VDR), we designed and synthesized a series of vitamin D analogues with and without 22-alkyl substituents. Vitamin D 34-43 vitamin D receptor Homo sapiens 54-57 30551386-5 2019 In regard to its effect on liver fibrosis, vitamin D possesses an anti-fibrotic effect on hepatic stellate cells via vitamin D receptor-mediated specific signal transduction pathways, which in turn inhibit expression of pro-fibrogenic genes. Vitamin D 43-52 vitamin D receptor Homo sapiens 117-135 31333100-3 2019 Recent research has been focusing on the role of vitamin D in the pathogenesis of endometriosis, basing on the evidence of the presence of vitamin D receptor and the enzymes required for vitamin D synthesis in the ectopic endometrium. Vitamin D 49-58 vitamin D receptor Homo sapiens 139-157 31298160-5 2019 Via activating the VDR, vitamin D has direct effects on the epigenome and the expression of more than 1000 genes in most human tissues and cell types. Vitamin D 24-33 vitamin D receptor Homo sapiens 19-22 30963970-10 2019 CONCLUSION: The presence of the TT allele of the SNP rs2228570 of the VDR gene and the SNP rs731236 of the CC genotype was associated with the presence of osteopenia and decreased bone mineral density alongside malfunctions of vitamin D. Vitamin D 227-236 vitamin D receptor Homo sapiens 70-73 31389312-3 2019 Since the vitamin D receptor (VDR) is widely distributed in vascular endothelial cells, vascular smooth muscle cells and cardiomyocytes, the role of vitamin D and VDR in hypertension has received extensive attention. Vitamin D 10-19 vitamin D receptor Homo sapiens 30-33 31333100-7 2019 RESULTS: The relationship between endometriosis and Vitamin D has been analyzed through the evaluation of vitamin D serum level, the polymorphism of vitamin D receptor and the role of vitamin D-binding protein in patient with endometriosis. Vitamin D 52-61 vitamin D receptor Homo sapiens 149-167 31298160-6 2019 CONCLUSIONS: The pleiotropic action of vitamin D in health and disease prevention is explained through complex gene regulatory events of the transcription factor VDR. Vitamin D 39-48 vitamin D receptor Homo sapiens 162-165 30395535-4 2018 The biological activity of vitamin D occurs via two pathways: non-genomic and genomic responses, both of which involve binding of 1,25-dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D binding to the vitamin D receptor (VDR). Vitamin D 27-36 vitamin D receptor Homo sapiens 218-236 31532316-9 2019 Immune histochemical examination showed homogenous distribution of vitamin D and VDR expression in syncytiotrophoblasts, cytotrophoblasts and chorion villus stroma.Vitamin D expression relative area was 10,3% which is statistically different from the induced abortion group - 15,4% (p<0,01). Vitamin D 164-173 vitamin D receptor Homo sapiens 81-84 31532316-13 2019 Also in missed abortion group, positively significant correlation has been determined between the level of vitamin D in blood and VDR relative area expression (r = 0,412). Vitamin D 107-116 vitamin D receptor Homo sapiens 130-133 29981368-2 2019 Many mechanistic studies show that the active vitamin D metabolite (1alpha,25-dihydroxyvitamin D3 or calcitriol) inhibits proliferation and promotes epithelial differentiation of human colon carcinoma cell lines that express vitamin D receptor (VDR) via the regulation of a high number of genes. Vitamin D 46-55 vitamin D receptor Homo sapiens 225-243 29981368-2 2019 Many mechanistic studies show that the active vitamin D metabolite (1alpha,25-dihydroxyvitamin D3 or calcitriol) inhibits proliferation and promotes epithelial differentiation of human colon carcinoma cell lines that express vitamin D receptor (VDR) via the regulation of a high number of genes. Vitamin D 46-55 vitamin D receptor Homo sapiens 245-248 30092343-3 2018 Vitamin D activity is mediated by its receptor (VDR), which acts as a transcription factor modulating the expression of genes triggering the response against viruses. Vitamin D 0-9 vitamin D receptor Homo sapiens 48-51 30314996-0 2018 Vitamin D-induced vitamin D receptor expression induces tamoxifen sensitivity in MCF-7 stem cells via suppression of Wnt/beta-catenin signaling. Vitamin D 0-9 vitamin D receptor Homo sapiens 18-36 30314996-9 2018 Vitamin D enhanced VDR expression and induced DNA damage. Vitamin D 0-9 vitamin D receptor Homo sapiens 19-22 30314996-16 2018 Vitamin D-induced VDR expression increased the sensitivity of MCF-7 stem cells to tamoxifen by inhibiting Wnt/beta-catenin signaling. Vitamin D 0-9 vitamin D receptor Homo sapiens 18-21 30248338-3 2018 The authors transduced human hepatocyte-derived cells with an adenoviral vector encoding human VDR and found that angiopoietin-like protein 8 (ANGPTL8) expression was increased upon VDR activation by vitamin D or lithocholic acid. Vitamin D 200-209 vitamin D receptor Homo sapiens 95-98 30248338-3 2018 The authors transduced human hepatocyte-derived cells with an adenoviral vector encoding human VDR and found that angiopoietin-like protein 8 (ANGPTL8) expression was increased upon VDR activation by vitamin D or lithocholic acid. Vitamin D 200-209 vitamin D receptor Homo sapiens 182-185 31235092-3 2019 Vitamin D acts against IR by its anti-inflammatory and regulation of insulin secretion as pancreatic beta cells express vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 120-138 31235092-3 2019 Vitamin D acts against IR by its anti-inflammatory and regulation of insulin secretion as pancreatic beta cells express vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 140-143 30137362-3 2019 Furthermore, vitamin D receptor (VDR) and vitamin D-metabolizing enzymes [cytochrome 450 (CYP)] expression in adipose tissue (AT) might affect AT insulin sensitivity. Vitamin D 13-22 vitamin D receptor Homo sapiens 33-36 30044963-0 2019 Machine learning approaches infer vitamin D signaling: Critical impact of vitamin D receptor binding within topologically associated domains. Vitamin D 34-43 vitamin D receptor Homo sapiens 74-92 30044963-8 2019 The relative amounts of these VDR categories in TADs showed to be the main discriminator for sorting the latter into five classes carrying vitamin D target genes involved in distinct biological processes. Vitamin D 139-148 vitamin D receptor Homo sapiens 30-33 30044963-9 2019 In conclusion, via the application of machine learning methods we identified the spatio-temporal VDR binding pattern in TADs as the most critical attribute for specific regulation of vitamin D target genes and the segregation of vitamin D"s physiologic function. Vitamin D 183-192 vitamin D receptor Homo sapiens 97-100 30044963-9 2019 In conclusion, via the application of machine learning methods we identified the spatio-temporal VDR binding pattern in TADs as the most critical attribute for specific regulation of vitamin D target genes and the segregation of vitamin D"s physiologic function. Vitamin D 229-238 vitamin D receptor Homo sapiens 97-100 30671219-3 2019 Vitamin D receptors (VDR) genetic variants may be related to vitamin D status and BMD. Vitamin D 61-70 vitamin D receptor Homo sapiens 0-19 30671219-3 2019 Vitamin D receptors (VDR) genetic variants may be related to vitamin D status and BMD. Vitamin D 61-70 vitamin D receptor Homo sapiens 21-24 30671219-4 2019 Objectives: To evaluate the effect of VDR genetic variants on vitamin D levels and BMD in betaTM Egyptian patients supplemented with vitamin D. Vitamin D 62-71 vitamin D receptor Homo sapiens 38-41 30671219-4 2019 Objectives: To evaluate the effect of VDR genetic variants on vitamin D levels and BMD in betaTM Egyptian patients supplemented with vitamin D. Vitamin D 133-142 vitamin D receptor Homo sapiens 38-41 30358420-0 2019 Modulation of VDR and Cell Cycle-Related Proteins by Vitamin D in Normal Pancreatic Cells and Poorly Differentiated Metastatic Pancreatic Cancer Cells. Vitamin D 53-62 vitamin D receptor Homo sapiens 14-17 30358420-6 2019 A further increase in 1,25-dihydroxyvitamin D3 concentration above the physiological range significantly downregulated the expression of VDR, indicating that VDR is modulated by VDR levels to maintain normal functioning during dramatic variations in vitamin D concentration. Vitamin D 36-45 vitamin D receptor Homo sapiens 137-140 30358420-6 2019 A further increase in 1,25-dihydroxyvitamin D3 concentration above the physiological range significantly downregulated the expression of VDR, indicating that VDR is modulated by VDR levels to maintain normal functioning during dramatic variations in vitamin D concentration. Vitamin D 36-45 vitamin D receptor Homo sapiens 158-161 30358420-6 2019 A further increase in 1,25-dihydroxyvitamin D3 concentration above the physiological range significantly downregulated the expression of VDR, indicating that VDR is modulated by VDR levels to maintain normal functioning during dramatic variations in vitamin D concentration. Vitamin D 36-45 vitamin D receptor Homo sapiens 158-161 30562127-3 2019 We report here original findings on the ways in which vitamin D receptor (VDR) gene polymorphic variation (FokI, BsmI, ApaI, and TaqI polymorphisms) impacts serum vitamin D concentration and, additionally, susceptibility to OSAS. Vitamin D 54-63 vitamin D receptor Homo sapiens 74-77 30562127-7 2019 VDR FokI polymorphism explained 14.5% of vitamin D serum concentration variability. Vitamin D 41-50 vitamin D receptor Homo sapiens 0-3 30648951-1 2018 2alpha-modification on the vitamin D skeleton with a 2alpha-(omega-hydroxyalkyl) or 2alpha-(omega-hydroxyalkoxy) group improves vitamin D receptor (VDR) binding affinity, lengthens the half-life in target cells because of increased resistance to CYP24A1 metabolism, and enhances biological activity. Vitamin D 27-36 vitamin D receptor Homo sapiens 128-146 30648951-1 2018 2alpha-modification on the vitamin D skeleton with a 2alpha-(omega-hydroxyalkyl) or 2alpha-(omega-hydroxyalkoxy) group improves vitamin D receptor (VDR) binding affinity, lengthens the half-life in target cells because of increased resistance to CYP24A1 metabolism, and enhances biological activity. Vitamin D 27-36 vitamin D receptor Homo sapiens 148-151 30395535-4 2018 The biological activity of vitamin D occurs via two pathways: non-genomic and genomic responses, both of which involve binding of 1,25-dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D binding to the vitamin D receptor (VDR). Vitamin D 27-36 vitamin D receptor Homo sapiens 238-241 30395535-4 2018 The biological activity of vitamin D occurs via two pathways: non-genomic and genomic responses, both of which involve binding of 1,25-dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D binding to the vitamin D receptor (VDR). Vitamin D 144-153 vitamin D receptor Homo sapiens 218-236 30395535-4 2018 The biological activity of vitamin D occurs via two pathways: non-genomic and genomic responses, both of which involve binding of 1,25-dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D binding to the vitamin D receptor (VDR). Vitamin D 144-153 vitamin D receptor Homo sapiens 238-241 30555790-1 2019 Background: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been linked to type 2 diabetes mellitus (T2DM) and its metabolic parameters, however there are conflicting results therefore we aimed to evaluate VDR gene polymorphisms (Fok1, Bsm1 and Taq1) and vitamin D status in Egyptian patients with T2DM and to detect the associations of these polymorphisms to their metabolic parameters and glycemic control. Vitamin D 12-21 vitamin D receptor Homo sapiens 232-235 29972092-3 2018 Among these, vitamin D and hence its receptor (VDR) gene polymorphisms have gained much interest; however, the results are still controversial. Vitamin D 13-22 vitamin D receptor Homo sapiens 47-50 30555790-1 2019 Background: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been linked to type 2 diabetes mellitus (T2DM) and its metabolic parameters, however there are conflicting results therefore we aimed to evaluate VDR gene polymorphisms (Fok1, Bsm1 and Taq1) and vitamin D status in Egyptian patients with T2DM and to detect the associations of these polymorphisms to their metabolic parameters and glycemic control. Vitamin D 37-46 vitamin D receptor Homo sapiens 57-60 30555790-1 2019 Background: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been linked to type 2 diabetes mellitus (T2DM) and its metabolic parameters, however there are conflicting results therefore we aimed to evaluate VDR gene polymorphisms (Fok1, Bsm1 and Taq1) and vitamin D status in Egyptian patients with T2DM and to detect the associations of these polymorphisms to their metabolic parameters and glycemic control. Vitamin D 37-46 vitamin D receptor Homo sapiens 232-235 30268505-7 2018 Additionally, the binding affinity of the vitamin D analogs for the wild-type and the rickets-associated mutant R274L of VDR was evaluated. Vitamin D 42-51 vitamin D receptor Homo sapiens 121-124 30555810-2 2018 Homozygous or heterozygous mutations in the vitamin D receptor (VDR) gene leading to complete or partial target organ resistance to the action of 1alpha, 25-dihydroxyvitamin D3 (the active form of vitamin D) are responsible for HVDRR. Vitamin D 44-53 vitamin D receptor Homo sapiens 64-67 30408071-8 2018 Maternal vitamin D deficiency was found in all pathological pregnancies combined with significantly reduced staining levels of placental VDR in IUGR. Vitamin D 9-18 vitamin D receptor Homo sapiens 137-140 30484666-1 2018 Resistance to vitamin D has been known for decades as vitamin D resistant rickets, caused by mutations of the gene encoding for vitamin D receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 128-146 30484666-1 2018 Resistance to vitamin D has been known for decades as vitamin D resistant rickets, caused by mutations of the gene encoding for vitamin D receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 148-151 30484666-1 2018 Resistance to vitamin D has been known for decades as vitamin D resistant rickets, caused by mutations of the gene encoding for vitamin D receptor (VDR). Vitamin D 54-63 vitamin D receptor Homo sapiens 128-146 30484666-1 2018 Resistance to vitamin D has been known for decades as vitamin D resistant rickets, caused by mutations of the gene encoding for vitamin D receptor (VDR). Vitamin D 54-63 vitamin D receptor Homo sapiens 148-151 30481178-3 2018 Vitamin D has been shown to control several host immunomodulating properties through VDR gene. Vitamin D 0-9 vitamin D receptor Homo sapiens 85-88 30400332-5 2018 Two key observations validate this important non-classical action of vitamin D: first, vitamin D receptor (VDR) is expressed by the majority of immune cells, including B and T lymphocytes, monocytes, macrophages, and dendritic cells; second, there is an active vitamin D metabolism by immune cells that is able to locally convert 25(OH)D3 into 1,25(OH)2D3, its active form. Vitamin D 69-78 vitamin D receptor Homo sapiens 87-105 30400332-5 2018 Two key observations validate this important non-classical action of vitamin D: first, vitamin D receptor (VDR) is expressed by the majority of immune cells, including B and T lymphocytes, monocytes, macrophages, and dendritic cells; second, there is an active vitamin D metabolism by immune cells that is able to locally convert 25(OH)D3 into 1,25(OH)2D3, its active form. Vitamin D 69-78 vitamin D receptor Homo sapiens 107-110 30400332-5 2018 Two key observations validate this important non-classical action of vitamin D: first, vitamin D receptor (VDR) is expressed by the majority of immune cells, including B and T lymphocytes, monocytes, macrophages, and dendritic cells; second, there is an active vitamin D metabolism by immune cells that is able to locally convert 25(OH)D3 into 1,25(OH)2D3, its active form. Vitamin D 87-96 vitamin D receptor Homo sapiens 107-110 30257386-0 2018 Astemizole promotes the anti-tumor effect of vitamin D through inhibiting miR-125a-5p-meidated regulation of VDR in HCC. Vitamin D 45-54 vitamin D receptor Homo sapiens 109-112 30257386-7 2018 Downregulation of VDR significantly inhibited the synergistic effect of Vitamin D and astemizole on HCC cell viability, proliferation, apoptosis, migration and invasion. Vitamin D 72-81 vitamin D receptor Homo sapiens 18-21 30257386-13 2018 We identified that inhibition of miR-125a-5p and subsequent upregulation of VDR was involved in astemizole-induced enhancement of the anti-tumor effect of Vitamin D in HCC. Vitamin D 155-164 vitamin D receptor Homo sapiens 76-79 30326825-13 2018 CONCLUSIONS: These findings indicate that VDR expression is downregulated in HBV-transfected cells, thereby preventing vitamin D from inhibiting transcription and translation of HBV in vitro. Vitamin D 119-128 vitamin D receptor Homo sapiens 42-45 28696084-2 2018 BACKGROUND: The presence of the vitamin D receptor (VDR) has been recently demonstrated in human muscle supporting the theory of a role of vitamin D in the proliferation and differentiation of muscle cells. Vitamin D 32-41 vitamin D receptor Homo sapiens 52-55 30326825-7 2018 Vitamin D signaling pathway activation was evaluated by measuring the expression levels of VDR, CYP24A1, Tumor necrosis factor alpha (TNFalpha) and cathelicidin (CAMP) by qRT-PCR. Vitamin D 0-9 vitamin D receptor Homo sapiens 91-94 30349256-2 2018 Through interaction with its receptor (VDR) and the related enzymes (CYP27B1, CYP24A1), vitamin D modulates neurodevelopment, neuroprotection, and immunomodulation. Vitamin D 88-97 vitamin D receptor Homo sapiens 39-42 30234384-3 2018 Vitamin D, a secosteroid hormone, interacts with its nuclear receptor vitamin D receptor (VDR) to regulate crucial biological processes, such as bone metabolism and immune function modulation. Vitamin D 0-9 vitamin D receptor Homo sapiens 70-88 30234384-3 2018 Vitamin D, a secosteroid hormone, interacts with its nuclear receptor vitamin D receptor (VDR) to regulate crucial biological processes, such as bone metabolism and immune function modulation. Vitamin D 0-9 vitamin D receptor Homo sapiens 90-93 30319189-3 2018 Therefore the present study was aimed to investigate the pattern of allelic variants of VDR gene polymorphism (FokI and BsmI), its influence on vitamin D levels and bone mineral density (BMD) in North Indian postmenopausal women with osteoporosis for possible genetic association. Vitamin D 144-153 vitamin D receptor Homo sapiens 88-91 29885880-9 2018 CONCLUSION: Calcipotriol induces local structure rearrangements in VDR that could possibly translate into a superior clinical potential to execute important non-classical vitamin D effects such as inhibition of HCV replication. Vitamin D 171-180 vitamin D receptor Homo sapiens 67-70 30364037-1 2018 The biologically active form of vitamin D, 1,25 dihydroxyvitamin D (1,25(OH)2D) and its receptor, the vitamin D receptor (VDR), play roles in maintaining oral immunity and the integrity of the periodontium. Vitamin D 32-41 vitamin D receptor Homo sapiens 102-120 30364037-1 2018 The biologically active form of vitamin D, 1,25 dihydroxyvitamin D (1,25(OH)2D) and its receptor, the vitamin D receptor (VDR), play roles in maintaining oral immunity and the integrity of the periodontium. Vitamin D 32-41 vitamin D receptor Homo sapiens 122-125 30208925-7 2018 The methylation of the promoter regions of key genes in the vitamin D metabolic pathway (CYP24A1, CYP27A1, CYP27B1, CYP2R1, and VDR) was detected using the Illumina MiSeq platform. Vitamin D 60-69 vitamin D receptor Homo sapiens 128-131 29885880-5 2018 RESULTS: The structurally related vitamin D analogs calcipotriol and tacalcitiol, but not calcitriol itself, suppressed HCV replication in a VDR-dependent manner. Vitamin D 34-43 vitamin D receptor Homo sapiens 141-144 31729346-1 2018 Background Vitamin D deficiency is commonly identified in beta thalassemia major patients, related to iron accumulation.Vitamin D mediates its action upon binding to vitamin D receptor (VDR), a classical nuclear receptor. Vitamin D 11-20 vitamin D receptor Homo sapiens 166-184 31729346-1 2018 Background Vitamin D deficiency is commonly identified in beta thalassemia major patients, related to iron accumulation.Vitamin D mediates its action upon binding to vitamin D receptor (VDR), a classical nuclear receptor. Vitamin D 11-20 vitamin D receptor Homo sapiens 186-189 31729346-1 2018 Background Vitamin D deficiency is commonly identified in beta thalassemia major patients, related to iron accumulation.Vitamin D mediates its action upon binding to vitamin D receptor (VDR), a classical nuclear receptor. Vitamin D 120-129 vitamin D receptor Homo sapiens 166-184 31729346-1 2018 Background Vitamin D deficiency is commonly identified in beta thalassemia major patients, related to iron accumulation.Vitamin D mediates its action upon binding to vitamin D receptor (VDR), a classical nuclear receptor. Vitamin D 120-129 vitamin D receptor Homo sapiens 186-189 29857077-3 2018 The VDR gene was found to regulate the immunomodulatory effects of vitamin D and it enhances the innate immunity system. Vitamin D 67-76 vitamin D receptor Homo sapiens 4-7 30150596-0 2018 Association between Vitamin D Deficiency and Single Nucleotide Polymorphisms in the Vitamin D Receptor and GC Genes and Analysis of Their Distribution in Mexican Postmenopausal Women. Vitamin D 20-29 vitamin D receptor Homo sapiens 84-102 30205552-1 2018 Vitamin D is a steroid-like hormone which acts by binding to vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 61-79 30205552-1 2018 Vitamin D is a steroid-like hormone which acts by binding to vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 81-84 29702263-5 2018 The purpose of this study was to examine the effects of vitamin D metabolites (VDM) on the expression of estrogen receptors (ERs), VDR, and 1OHase mRNA, and to evaluate the inhibitory effect of low doses of sorafenib in combination with cDtboc and VDM on cell proliferation in cultured human papillary thyroid carcinoma (PTC). Vitamin D 56-65 vitamin D receptor Homo sapiens 131-134 30200275-0 2018 Antiproliferative Activity of Non-Calcemic Vitamin D Analogs on Human Melanoma Lines in Relation to VDR and PDIA3 Receptors. Vitamin D 43-52 vitamin D receptor Homo sapiens 100-103 30200275-7 2018 On the other hand, the expression of VDR and its splicing variants and other vitamin D related genes (RXR, PDIA3, CYP3A4, CYP2R1, CYP27B1, CYP24A1 and CYP11A1) was detected in WM98 and A375 melanomas with the transcript levels being modulated by vitamin D analogs. Vitamin D 246-255 vitamin D receptor Homo sapiens 37-40 30410834-3 2018 Due to the close association of vitamin D with the brain, it has been found that in the pathophysiology of several neuropsychiatric disorders vitamin D receptor (VDR) polymorphism plays a significant role. Vitamin D 32-41 vitamin D receptor Homo sapiens 142-160 30410834-3 2018 Due to the close association of vitamin D with the brain, it has been found that in the pathophysiology of several neuropsychiatric disorders vitamin D receptor (VDR) polymorphism plays a significant role. Vitamin D 32-41 vitamin D receptor Homo sapiens 162-165 29949513-2 2018 The circulating active form of vitamin D, 1,25-dihydroxyvitamin D, binds to the vitamin D receptor (VDR), which heterodimerizes with the retinoid X receptor to regulate the expression of target genes. Vitamin D 31-40 vitamin D receptor Homo sapiens 80-98 29949513-2 2018 The circulating active form of vitamin D, 1,25-dihydroxyvitamin D, binds to the vitamin D receptor (VDR), which heterodimerizes with the retinoid X receptor to regulate the expression of target genes. Vitamin D 31-40 vitamin D receptor Homo sapiens 100-103 29949513-3 2018 Inactivating mutations in the VDR gene cause hereditary vitamin D-resistant rickets (HVDRR), a rare disorder characterized by an early onset of rickets, growth retardation, skeletal deformities, hypocalcemia, hypophosphatemia and secondary hyperparathyroidism, and in some cases alopecia. Vitamin D 56-65 vitamin D receptor Homo sapiens 30-33 30150667-1 2018 Based on an inverse association between vitamin D levels and the risks of colorectal diseases, a functional start codon polymorphism in the vitamin D receptor (VDR) gene is speculated to affect the risks for these diseases. Vitamin D 40-49 vitamin D receptor Homo sapiens 140-158 30150667-1 2018 Based on an inverse association between vitamin D levels and the risks of colorectal diseases, a functional start codon polymorphism in the vitamin D receptor (VDR) gene is speculated to affect the risks for these diseases. Vitamin D 40-49 vitamin D receptor Homo sapiens 160-163 30150419-4 2018 However, several active metabolites of vitamin D can exert both direct action, mainly via vitamin D3 receptor trans-activation and indirect actions on several other tissues by an endocrine, autocrine and paracrine manners. Vitamin D 39-48 vitamin D receptor Homo sapiens 90-109 30138371-3 2018 Therefore, we wanted to search for differences in expression of genes involved in the vitamin D receptor (VDR) activation pathway and genes that are known to alter upon vitamin D stimulation, in the aortic adventitia of CAD patients with and without RA. Vitamin D 86-95 vitamin D receptor Homo sapiens 106-109 31194013-2 2019 We construct this case-control study to investigate the association between maternal serum vitamin D level & VDR gene Fok1 polymorphism and risk of congenital heart defects (CHD) in offspring. Vitamin D 91-100 vitamin D receptor Homo sapiens 113-116 30142216-4 2018 Therefore, we investigated the relationship between vitamin D levels and brain phenotypes in psychotic disorders, and assessed possible interactions with genetic variants in vitamin D receptor (VDR) and other genetic variants that play a role in vitamin D levels in the body. Vitamin D 174-183 vitamin D receptor Homo sapiens 194-197 29987250-0 2018 Vitamin D"s Effect on the Proliferation and Inflammation of Human Intervertebral Disc Cells in Relation to the Functional Vitamin D Receptor Gene FokI Polymorphism. Vitamin D 0-9 vitamin D receptor Homo sapiens 122-140 30110122-6 2018 The discovery of vitamin D receptor (VDR) presence outside the skeletal system allowed to conclude, that vitamin D is responsible not only for mineral economy, but also for immunological processes, respiratory status, intestial microflora and cystic fibrosis - related diabetes (CFRD) course. Vitamin D 17-26 vitamin D receptor Homo sapiens 37-40 30103977-1 2018 Vitamin D receptor (VDR) and its ligand Vitamin D, play a crucial role in regulating multiple pathways for maintaining vascular health. Vitamin D 0-9 vitamin D receptor Homo sapiens 20-23 30107003-6 2018 The vitamin D receptor gene (VDR) was selected, and the interactions of genetic variation in VDR with circulating vitamin D levels and gemcitabine treatment were evaluated. Vitamin D 4-13 vitamin D receptor Homo sapiens 29-32 29533153-3 2018 Vitamin D receptor enzymes that metabolize vitamin D are expressed in both central and peripheral reproductive organs. Vitamin D 43-52 vitamin D receptor Homo sapiens 0-18 30202762-1 2018 Objectives: To investigate if vitamin D receptor (VDR) gene polymorphisms and circulating vitamin D levels are associated with pelvic floor disorders (PFDs). Vitamin D 30-39 vitamin D receptor Homo sapiens 50-53 30202762-8 2018 Taken together, our observations suggest that vitamin D levels could be associated with PFDs and that 2 polymorphisms (i.e., ApaI and BsmI) in the VDR gene may contribute to an increased prevalence of PFDs in women with insufficient levels of vitamin D. Vitamin D 46-55 vitamin D receptor Homo sapiens 147-150 30202762-8 2018 Taken together, our observations suggest that vitamin D levels could be associated with PFDs and that 2 polymorphisms (i.e., ApaI and BsmI) in the VDR gene may contribute to an increased prevalence of PFDs in women with insufficient levels of vitamin D. Vitamin D 243-252 vitamin D receptor Homo sapiens 147-150 29936834-1 2018 We designed and synthesized vitamin D analogues with an electrophile as covalent modifiers for the vitamin D receptor (VDR). Vitamin D 28-37 vitamin D receptor Homo sapiens 99-117 29936834-1 2018 We designed and synthesized vitamin D analogues with an electrophile as covalent modifiers for the vitamin D receptor (VDR). Vitamin D 28-37 vitamin D receptor Homo sapiens 119-122 29936834-2 2018 Novel vitamin D analogues 1-4 have an electrophilic enone group at the side chain for conjugate addition to His301 or His393 in the VDR. Vitamin D 6-15 vitamin D receptor Homo sapiens 132-135 29936834-9 2018 We successfully synthesized vitamin D analogues that form a covalent bond with VDR-LBD. Vitamin D 28-37 vitamin D receptor Homo sapiens 79-82 29575677-1 2018 The active form of vitamin D (1alpha,25-dihydroxyvitamin D) acts as a steroid hormone and binds to the vitamin D receptor. Vitamin D 19-28 vitamin D receptor Homo sapiens 103-121 30018005-0 2018 The impact of the vitamin D-modulated epigenome on VDR target gene regulation. Vitamin D 18-27 vitamin D receptor Homo sapiens 51-54 30018005-1 2018 The micronutrient vitamin D significantly modulates the human epigenome via enhancing genome-wide the rate of accessible chromatin and vitamin D receptor (VDR) binding. Vitamin D 18-27 vitamin D receptor Homo sapiens 135-153 30018005-1 2018 The micronutrient vitamin D significantly modulates the human epigenome via enhancing genome-wide the rate of accessible chromatin and vitamin D receptor (VDR) binding. Vitamin D 18-27 vitamin D receptor Homo sapiens 155-158 29977597-1 2018 Vitamin D, a fat-soluble prohormone, has wide-ranging roles in the regulation of many physiological processes through their interactions with the vitamin D receptors (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 146-165 29476020-8 2018 In presence of vitamin D receptor (VDR), DBP promoted cell aggression (invasion and doubling time) via activation of the insulin-like growth factor-1/insulin-like growth factor-binding protein-2/Akt axis, and induced suppression of vitamin D-responsive genes. Vitamin D 15-24 vitamin D receptor Homo sapiens 35-38 30066819-1 2018 OBJECTIVE: To verify the relationship between polymorphisms of the vitamin D receptor gene (VDR), clinical findings, and serum vitamin D (VD) levels in asthmatics. Vitamin D 67-76 vitamin D receptor Homo sapiens 92-95 29977597-1 2018 Vitamin D, a fat-soluble prohormone, has wide-ranging roles in the regulation of many physiological processes through their interactions with the vitamin D receptors (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 167-170 29899561-2 2018 In this study, we found that at a physiological concentration, 25(OH)D3 (25D3), the precursor of 1,25D3 and an inactive form of vitamin D because of its much weaker binding activity to the vitamin D receptor (VDR) compared with 1,25D3, had a gene expression profile similar to that of 1,25D3 in prostate cancer LNCaP cells. Vitamin D 128-137 vitamin D receptor Homo sapiens 189-207 29922235-1 2018 Vitamin D receptor (VDR) is one of the main mediators of vitamin D biological activity. Vitamin D 57-66 vitamin D receptor Homo sapiens 0-18 29874855-1 2018 Vitamin D receptor (VDR) mediates many genomic and non-genomic effects of vitamin D. Vitamin D 74-83 vitamin D receptor Homo sapiens 0-18 29788141-1 2018 Background: Vitamin D signaling modulates inflammation through the vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 67-85 29788141-1 2018 Background: Vitamin D signaling modulates inflammation through the vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 87-90 29922235-1 2018 Vitamin D receptor (VDR) is one of the main mediators of vitamin D biological activity. Vitamin D 57-66 vitamin D receptor Homo sapiens 20-23 29874855-1 2018 Vitamin D receptor (VDR) mediates many genomic and non-genomic effects of vitamin D. Vitamin D 74-83 vitamin D receptor Homo sapiens 20-23 29130299-2 2018 A nuclear receptor (VDR) mediates vitamin D actions in a lot of organs like bowel, bone, kidney, breast, gonads, pancreas, brain, cardiovascular and immune systems. Vitamin D 34-43 vitamin D receptor Homo sapiens 20-23 29767851-7 2018 Lower 25-OHD levels were also associated with increased expression of CYP3A4, and with decreased expression of GC (also termed DBP) and VDR, three genes involved in vitamin D metabolism. Vitamin D 165-174 vitamin D receptor Homo sapiens 136-139 29726119-7 2018 Additionally, genotyping of 296 SNPs in the same subjects resulted in findings that 27 SNPs, predominantly in CYP24A1 and VDR genes, were significantly associated with lung cancer status, affected mRNA expression, and modulated vitamin D levels. Vitamin D 228-237 vitamin D receptor Homo sapiens 122-125 29452294-3 2018 We evaluated the impact of polymorphisms in genes (CYP27B1, CYP24A1, VDBP and VDR) related to vitamin D pathway on sofosbuvir and GS-331007 plasma levels in HCV mono-infected patients at one month of treatment. Vitamin D 94-103 vitamin D receptor Homo sapiens 78-81 29778131-2 2018 Vitamin D receptor (VDR) is a member of the steroid receptor family that mediates the effects of vitamin D by regulating transcription of multiple cellular genes. Vitamin D 97-106 vitamin D receptor Homo sapiens 0-18 29778131-2 2018 Vitamin D receptor (VDR) is a member of the steroid receptor family that mediates the effects of vitamin D by regulating transcription of multiple cellular genes. Vitamin D 97-106 vitamin D receptor Homo sapiens 20-23 29778131-9 2018 CONCLUSIONS: VDR is an important receptor in the pathogenesis of UC, and optimizing vitamin D levels could have a therapeutic role in UC. Vitamin D 84-93 vitamin D receptor Homo sapiens 13-16 29795187-1 2018 Epidemiological studies have confirmed associations of the vitamin D receptor (VDR) and vitamin D-related gene polymorphisms with adiposity and other metabolic disturbances. Vitamin D 59-68 vitamin D receptor Homo sapiens 79-82 29875733-3 2018 The model describes, how VDR"s spatio-temporal binding profile provides key insight into the pleiotropic action of vitamin D. Vitamin D 115-124 vitamin D receptor Homo sapiens 25-28 29790402-1 2018 AIM: Vitamin D (VD) influences genetic expression through its receptor (VDR). Vitamin D 5-14 vitamin D receptor Homo sapiens 72-75 29080365-2 2018 Narrow-band UVB (NB-UVB) treatment of vitiligo might act through its effects on vitamin D and its receptor.This study is the first to elucidate NB-UVB effects on immunohistochemical vitamin D receptor (VDR) expression in generalized vitiligo and correlate it with serum vitamin D and repigmentation response. Vitamin D 80-89 vitamin D receptor Homo sapiens 182-200 29951549-2 2018 1,25(OH)2D, the biologically active form of vitamin D, exerts most of its functions through the almost universally distributed nuclear vitamin D receptor (VDR). Vitamin D 44-53 vitamin D receptor Homo sapiens 135-153 29951549-2 2018 1,25(OH)2D, the biologically active form of vitamin D, exerts most of its functions through the almost universally distributed nuclear vitamin D receptor (VDR). Vitamin D 44-53 vitamin D receptor Homo sapiens 155-158 29951549-4 2018 In turn, VDR/RXR binds to DNA sequences termed vitamin D response elements in target genes, regulating gene transcription. Vitamin D 47-56 vitamin D receptor Homo sapiens 9-12 29176261-3 2018 But their exact relationship with clinical patients is still elusive, which inspired us to explore the potential association of vitamin D receptor (VDR) expression on circulating EPCs and serum vitamin D levels among patients with coronary artery disease (CAD). Vitamin D 128-137 vitamin D receptor Homo sapiens 148-151 29432829-3 2018 With respect to cancer, the genomic actions of vitamin D are mediated through binding to the Vitamin D Receptor (VDR), which allows it to modulate the expression of genes in a cell-and tissue-specific manner. Vitamin D 47-56 vitamin D receptor Homo sapiens 93-111 29432829-3 2018 With respect to cancer, the genomic actions of vitamin D are mediated through binding to the Vitamin D Receptor (VDR), which allows it to modulate the expression of genes in a cell-and tissue-specific manner. Vitamin D 47-56 vitamin D receptor Homo sapiens 113-116 29652161-1 2018 A convergent synthesis of side-chain locked vitamin D analogs 3 and 4, which bind strongly in silico to the vitamin D receptor (VDR), is described. Vitamin D 44-53 vitamin D receptor Homo sapiens 108-126 29652161-1 2018 A convergent synthesis of side-chain locked vitamin D analogs 3 and 4, which bind strongly in silico to the vitamin D receptor (VDR), is described. Vitamin D 44-53 vitamin D receptor Homo sapiens 128-131 29461981-1 2018 Genetic forms of vitamin D-dependent rickets (VDDRs) are due to mutations impairing activation of vitamin D or decreasing vitamin D receptor responsiveness. Vitamin D 17-26 vitamin D receptor Homo sapiens 122-140 29080365-2 2018 Narrow-band UVB (NB-UVB) treatment of vitiligo might act through its effects on vitamin D and its receptor.This study is the first to elucidate NB-UVB effects on immunohistochemical vitamin D receptor (VDR) expression in generalized vitiligo and correlate it with serum vitamin D and repigmentation response. Vitamin D 182-191 vitamin D receptor Homo sapiens 202-205 29281615-9 2018 The vitamin D/VDR pathway protects against intestinal injury of NEC partly through suppressing the expression of TLR4. Vitamin D 4-13 vitamin D receptor Homo sapiens 14-17 29657326-3 2018 Vitamin D, as a prohormone, undergoes two-step metabolism in liver and kidney to produce a biologically active metabolite, calcitriol, which binds to the vitamin D receptor (VDR) for the regulation of expression of diverse genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 154-172 29669566-3 2018 Vitamin D acts in tissues through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 38-56 29669566-3 2018 Vitamin D acts in tissues through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 58-61 29657326-3 2018 Vitamin D, as a prohormone, undergoes two-step metabolism in liver and kidney to produce a biologically active metabolite, calcitriol, which binds to the vitamin D receptor (VDR) for the regulation of expression of diverse genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 174-177 28994020-3 2018 Multiple factors are linked to vitamin D status, such as Fitzpatrick skin type, sex, body mass index, physical activity, alcohol intake, and vitamin D receptor polymorphisms. Vitamin D 31-40 vitamin D receptor Homo sapiens 141-159 29782293-0 2018 Mycosis Fungoides and Vitamin D Status: Analyses of Serum 25-Hydroxyvitamin D Levels and Single Nucleotide Polymorphisms in the Vitamin D Receptor Gene. Vitamin D 22-31 vitamin D receptor Homo sapiens 128-146 29458003-0 2018 FGF 23, PTH and vitamin D status in end stage renal disease patients affected by VDR FokI and BsmI variants. Vitamin D 16-25 vitamin D receptor Homo sapiens 81-84 29433089-2 2018 These physiological actions caused by vitamin D are triggered by the specific binding of vitamin D to its receptor (VDR). Vitamin D 38-47 vitamin D receptor Homo sapiens 116-119 29435763-1 2018 Vitamin D, synthesized in the skin or absorbed from the diet, undergoes multi-step enzymatic conversion to its active form, 1,25-dihydroxy vitamin D [1,25(OH)2D], followed by interaction with the vitamin D receptor (VDR), to modulate target gene expression. Vitamin D 0-9 vitamin D receptor Homo sapiens 196-214 29435763-1 2018 Vitamin D, synthesized in the skin or absorbed from the diet, undergoes multi-step enzymatic conversion to its active form, 1,25-dihydroxy vitamin D [1,25(OH)2D], followed by interaction with the vitamin D receptor (VDR), to modulate target gene expression. Vitamin D 0-9 vitamin D receptor Homo sapiens 216-219 29435763-9 2018 These actions demonstrate the critical role of vitamin D in regulating skeletal homeostasis both indirectly and directly via the 1,25(OH)2D/VDR system. Vitamin D 47-56 vitamin D receptor Homo sapiens 140-143 29549592-5 2018 In the present study, we evaluated vitamin D serum concentration as well as expression of vitamin D receptor (VDR) gene and genes encoding for vitamin D activating enzyme 1-alpha-hydroxylase (CYP27B1) and deactivating enzyme 24-hyroxylase (CYP24A1) in epileptic patients compared with healthy individuals. Vitamin D 90-99 vitamin D receptor Homo sapiens 110-113 29593729-8 2018 The development of new genetic tools using next-generation sequencing: e.g., chromatin immunoprecipitation sequencing (ChIP-seq) and the accompanying rapid progress of epigenomics has made it possible to recognize that the association between vitamin D and MS could be based on the extensive and characteristic genomic binding of the vitamin D receptor (VDR). Vitamin D 243-252 vitamin D receptor Homo sapiens 334-352 29593729-8 2018 The development of new genetic tools using next-generation sequencing: e.g., chromatin immunoprecipitation sequencing (ChIP-seq) and the accompanying rapid progress of epigenomics has made it possible to recognize that the association between vitamin D and MS could be based on the extensive and characteristic genomic binding of the vitamin D receptor (VDR). Vitamin D 243-252 vitamin D receptor Homo sapiens 354-357 29456680-11 2018 The results showed that children with bronchial asthma are often accompanied by different degrees of changes in VDR gene polymorphism, which is negatively correlated with the severity of asthma, so vitamin D should be strengthened to ameliorate the prognosis of children. Vitamin D 198-207 vitamin D receptor Homo sapiens 112-115 29433089-2 2018 These physiological actions caused by vitamin D are triggered by the specific binding of vitamin D to its receptor (VDR). Vitamin D 89-98 vitamin D receptor Homo sapiens 116-119 29433089-3 2018 Here we investigated the specific interactions and binding affinities between VDR and vitamin D derivatives, using ab initio fragment molecular orbital (FMO) calculations. Vitamin D 86-95 vitamin D receptor Homo sapiens 78-81 28602960-3 2018 Mutations in human VDR (hVDR) cause hereditary vitamin D resistant rickets, a genetic syndrome characterized by hypocalcemia, hyperparathyroidism and rickets resulting from dysregulation of mineral homeostasis. Vitamin D 47-56 vitamin D receptor Homo sapiens 19-22 29561429-3 2018 Deficiency of vitamin D and decreased levels of its receptor were observed in HCV and HCV-HCC patients.The perturbation in vitamin D/VDR axis, which modulates both of autophagy and apoptosis in HCV infection, may point out to its involvement and implication in the pathogenesis of HCV infection and the development of HCV-related HCC. Vitamin D 14-23 vitamin D receptor Homo sapiens 133-136 28870774-2 2018 VDR is the nuclear receptor for the biologically most active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3). Vitamin D 61-70 vitamin D receptor Homo sapiens 0-3 28870774-8 2018 In total, VDR sites with GABPA co-localization may control some 450 vitamin D target genes. Vitamin D 68-77 vitamin D receptor Homo sapiens 10-13 29018141-8 2018 The chromatin immunoprecipitation results suggested that C-Ret is directly regulated by vitamin D via VDR. Vitamin D 88-97 vitamin D receptor Homo sapiens 102-105 29506625-0 2018 VDBP, VDR Mutations and Other Factors Related With Vitamin D Metabolism May Be Associated With Type 1 Diabetes Mellitus. Vitamin D 51-60 vitamin D receptor Homo sapiens 6-9 29506625-3 2018 Therefore in this study it was aimed to investigate the associations between T1DM, vitamin D binding protein (VDBP) and vitamin D receptor (VDR) gene mutations which are related with vitamin D metabolism. Vitamin D 83-92 vitamin D receptor Homo sapiens 120-138 29506625-3 2018 Therefore in this study it was aimed to investigate the associations between T1DM, vitamin D binding protein (VDBP) and vitamin D receptor (VDR) gene mutations which are related with vitamin D metabolism. Vitamin D 83-92 vitamin D receptor Homo sapiens 140-143 29506625-10 2018 When the relation between the risk factors and mutations were investigated, it was found that VDBP, free vitamin D and bioactive vitamin D were significantly associated with rs7041 mutation in VDBP whereas HDL was significantly associated with rs2228570 mutation in VDR. Vitamin D 129-138 vitamin D receptor Homo sapiens 266-269 29467039-2 2018 The vitamin D plays a key role in regulation of calcium homeostasis and bone mineralization, exerting its biological activities by binding to a high-affinity receptor (VDR). Vitamin D 4-13 vitamin D receptor Homo sapiens 168-171 29287957-3 2018 VDR antagonists and partial agonists have been developed based on the secosteroid scaffold of vitamin D. Vitamin D 94-103 vitamin D receptor Homo sapiens 0-3 28710021-4 2018 Here we review our recent findings in this area, including our data revealing that reduction of the expression of the vitamin D receptor (Vdr) within BCa cells accelerates primary tumor growth and enables the development of metastases, demonstrating a tumor autonomous effect of vitamin D signaling to suppress BCa metastases. Vitamin D 118-127 vitamin D receptor Homo sapiens 138-141 29415666-2 2018 Therefore, the aim of this study was to examine the influence of vitamin D receptor (VDR) polymorphisms on secondary hyperparathyroidism and its association with vitamin D levels in black and white South African study participants. Vitamin D 65-74 vitamin D receptor Homo sapiens 85-88 29128634-3 2018 Vitamin D plays an important role in immune response modulation and its action occurs through the vitamin D receptor (VDR), which recently has been described as overexpressed in human placenta during the pregnancy. Vitamin D 0-9 vitamin D receptor Homo sapiens 98-116 29128634-3 2018 Vitamin D plays an important role in immune response modulation and its action occurs through the vitamin D receptor (VDR), which recently has been described as overexpressed in human placenta during the pregnancy. Vitamin D 0-9 vitamin D receptor Homo sapiens 118-121 29018141-6 2018 Overexpression of VDR in SH-SY5Y in the absence of ligand (mimicking in vivo developmental vitamin D deficiency) also suppressed C-Ret mRNA levels. Vitamin D 91-100 vitamin D receptor Homo sapiens 18-21 29233860-4 2018 Vitamin D receptor (VDR) expression is common to multiple immune cell types, and thus, pathway analysis of gene expression using data from multiple related models provides an inclusive perspective on the immunomodulatory impact of vitamin D. Vitamin D 231-240 vitamin D receptor Homo sapiens 0-18 29230954-4 2018 Vitamin D exerts its effect through vitamin D receptors (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 57-60 31038028-11 2018 Current evidence suggests that vitamin D supplementation in conjunction with standard of care (e.g. chemotherapy, radiation therapy) may confer clinical benefits such as a decrease in serum PSA levels and VDR expression but further research is required to ascertain these results. Vitamin D 31-40 vitamin D receptor Homo sapiens 205-208 29416220-2 2018 Vitamin D shows its effects on the immune system with the vitamin D receptor (VDR) in the nucleus. Vitamin D 0-9 vitamin D receptor Homo sapiens 58-76 29510848-3 2018 The groups were formed according to BTMD data, ethnic affiliation and according to content of vitamin D and gene polymorphism of vitamin D (VDR). Vitamin D 129-138 vitamin D receptor Homo sapiens 140-143 29416220-2 2018 Vitamin D shows its effects on the immune system with the vitamin D receptor (VDR) in the nucleus. Vitamin D 0-9 vitamin D receptor Homo sapiens 78-81 29416220-3 2018 Single nucleotide polymorphisms (SNPs) in the VDR gene can lead to alterations in vitamin D functions and metabolism.Taq I, Apa I, Fok I and Bsm I polymorphisms and MS associations have been investigated in many studies. Vitamin D 82-91 vitamin D receptor Homo sapiens 46-49 29032145-1 2018 Vitamin D has been established as a key factor in the development of obesity through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 89-107 30143987-4 2018 As VDR and the enzyme 1-alpha-hydroxylase are expressed in most immune cells, vitamin D modulates the phagocytic activity of macrophages and natural killer cells. Vitamin D 78-87 vitamin D receptor Homo sapiens 3-6 29032145-1 2018 Vitamin D has been established as a key factor in the development of obesity through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 109-112 29258108-0 2018 Vitamin D Status and Resting Metabolic Rate May Modify through Expression of Vitamin D Receptor and Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene in Overweight and Obese Adults. Vitamin D 0-9 vitamin D receptor Homo sapiens 77-95 29258108-3 2018 The aim of this study is to investigate the relationship between vitamin D effects on RMR in connection with the vitamin D receptor (VDR) and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha) gene expression. Vitamin D 65-74 vitamin D receptor Homo sapiens 113-131 29258108-3 2018 The aim of this study is to investigate the relationship between vitamin D effects on RMR in connection with the vitamin D receptor (VDR) and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha) gene expression. Vitamin D 65-74 vitamin D receptor Homo sapiens 133-136 29258108-10 2018 Linear regression analysis used to show the mediatory role of VDR and PGC-1alpha on the RMR/kg body weight and vitamin D status relationship. Vitamin D 111-120 vitamin D receptor Homo sapiens 62-65 29258108-11 2018 Our results showed that VDR had a mediatory effect on the relationship between RMR/kg body weight and vitamin D status (beta = 0.38, 95% CI -0.48 to 1.60; beta = -1.24, 95% CI -5.36 to 1.70). Vitamin D 102-111 vitamin D receptor Homo sapiens 24-27 30269113-3 2018 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3[1,25(OH)2D3], is a potent VDR ligand, and contributes to the maintenance of calcium homeostasis by enhancing intestinal calcium absorption, renal calcium reabsorption and bone resorption. Vitamin D 19-28 vitamin D receptor Homo sapiens 86-89 29874993-2 2018 Currently, several Vitamin D analogues have been synthesized and tested against VDR (Vitamin D Receptor). Vitamin D 19-28 vitamin D receptor Homo sapiens 80-83 29874993-10 2018 Furthermore, the hydroxyl group in the side chain of vitamin D analogues played an important role in the VDR antagonistic activity. Vitamin D 53-62 vitamin D receptor Homo sapiens 105-108 28876961-16 2018 CONCLUSIONS: As a consequence of the presence of VDR and 1alpha-hydroxylase in different parts of the eye, vitamin D replacement improves tear hyperosmolarity that is considered to be induced by ocular surface inflammation. Vitamin D 107-116 vitamin D receptor Homo sapiens 49-52 29183090-9 2018 In conclusion, low vitamin D status was in virtually healthy subjects associated with decreased insulin sensitivity, namely in those with GG genotype of rs2228570 VDR polymorphism. Vitamin D 19-28 vitamin D receptor Homo sapiens 163-166 30039758-2 2018 The active form of vitamin D, 25-hydroxyvitamin D, binds to vitamin D receptor (VDR) controlling the synthesis of many different proteins. Vitamin D 19-28 vitamin D receptor Homo sapiens 60-78 30039758-2 2018 The active form of vitamin D, 25-hydroxyvitamin D, binds to vitamin D receptor (VDR) controlling the synthesis of many different proteins. Vitamin D 19-28 vitamin D receptor Homo sapiens 80-83 30039758-4 2018 METHODS: We presented a comprehensive review of the evidence on the role of genetic polymorphisms, especially those of VDR, in vitamin D-related disorders including their clinical implications. Vitamin D 127-136 vitamin D receptor Homo sapiens 119-122 29143122-11 2018 Monitoring oxidative stress and VDR protein content might be useful for future studies on the mechanism(s) of vitamin D action in muscle. Vitamin D 110-119 vitamin D receptor Homo sapiens 32-35 30938651-1 2018 Hereditary vitamin D-resistant rickets (HVDRR) is a rare genetic disorder caused by mutations at the level of the vitamin D receptor ( VDR) gene. Vitamin D 11-20 vitamin D receptor Homo sapiens 114-132 30938651-1 2018 Hereditary vitamin D-resistant rickets (HVDRR) is a rare genetic disorder caused by mutations at the level of the vitamin D receptor ( VDR) gene. Vitamin D 11-20 vitamin D receptor Homo sapiens 41-44 30938651-6 2018 Treatment success depended on the position of the mutation within the VDR protein: children with the p.R391S mutation had a favorable outcome but maintained alopecia totalis, while 1 child with the p.H397P mutation and normal hair had no response to very high doses of vitamin D. Vitamin D 269-278 vitamin D receptor Homo sapiens 70-73 29067566-7 2018 At its optimal values (>30 ng/ml), vitamin D requires vitamin A for the binding to the vitamin D receptor and exert its anti-inflammatory action. Vitamin D 38-47 vitamin D receptor Homo sapiens 90-108 30300431-1 2018 Vitamin D activity is controlled by its receptor (VDR) located in many cells of the body. Vitamin D 0-9 vitamin D receptor Homo sapiens 50-53 28922293-4 2017 Data obtained in experimental models of cancer cachexia show that the administration of vitamin D to tumor-bearing animals is not able to prevent or delay both muscle wasting and adipose tissue depletion, despite increased expression of muscle vitamin D receptor. Vitamin D 88-97 vitamin D receptor Homo sapiens 244-262 28830874-8 2017 In gene-based tests, only VDR showed strong evidence of interaction (P = 0.04).Conclusions: SNPs in vitamin D-related genes may modify the association between serum 25(OH)D and breast cancer.Impact: This work strengthens the evidence for protective effects of vitamin D. Cancer Epidemiol Biomarkers Prev; 26(12); 1761-71. Vitamin D 100-109 vitamin D receptor Homo sapiens 26-29 29176823-9 2017 This suggested complex might also include VDR, which greatly contributes to Ca+2 hemostasis with its ligand vitamin D. Vitamin D 108-117 vitamin D receptor Homo sapiens 42-45 29220424-3 2017 Twelve SNPs involved in the vitamin D mechanistic pathways were studied [biosynthetic: rs4646536, rs10877012, rs3829251, rs1790349; activation: rs2060793, rs1993116; vitamin D-binding protein (VBP)/group-specific component (GC): rs4588, rs7041, rs2282679, rs1155563; and vitamin D receptor: rs1544410, rs10735810]. Vitamin D 28-37 vitamin D receptor Homo sapiens 271-289 28905271-1 2017 BACKGROUND: 2-Methylene-19-nor-(20S)-1alpha,25-dihydroxyvitamin D3 (DP001 or 2MD) is a novel, potent 1alpha-hydroxylated vitamin D analog that binds to the vitamin D receptor and suppresses parathyroid hormone synthesis and secretion with potential for an improved safety profile compared to existing active vitamin D analogs. Vitamin D 56-65 vitamin D receptor Homo sapiens 156-174 28905271-1 2017 BACKGROUND: 2-Methylene-19-nor-(20S)-1alpha,25-dihydroxyvitamin D3 (DP001 or 2MD) is a novel, potent 1alpha-hydroxylated vitamin D analog that binds to the vitamin D receptor and suppresses parathyroid hormone synthesis and secretion with potential for an improved safety profile compared to existing active vitamin D analogs. Vitamin D 121-130 vitamin D receptor Homo sapiens 156-174 29278636-2 2017 The genetic activity of vitamin D is determined through vitamin D receptors (VDR), a member of stero-thyreoidal family of nuclear receptors, which with vitamin D form a cell nucleus complex responsible for the chemo preventive and antitumor effect. Vitamin D 24-33 vitamin D receptor Homo sapiens 56-75 29278636-2 2017 The genetic activity of vitamin D is determined through vitamin D receptors (VDR), a member of stero-thyreoidal family of nuclear receptors, which with vitamin D form a cell nucleus complex responsible for the chemo preventive and antitumor effect. Vitamin D 24-33 vitamin D receptor Homo sapiens 77-80 29278636-2 2017 The genetic activity of vitamin D is determined through vitamin D receptors (VDR), a member of stero-thyreoidal family of nuclear receptors, which with vitamin D form a cell nucleus complex responsible for the chemo preventive and antitumor effect. Vitamin D 56-65 vitamin D receptor Homo sapiens 77-80 29127362-0 2017 Functional Analysis of VDR Gene Mutation R343H in A Child with Vitamin D-Resistant Rickets with Alopecia. Vitamin D 63-72 vitamin D receptor Homo sapiens 23-26 29209434-6 2017 The studies presented in this review suggest that whether vitamin D may have beneficial effects in disease course or not, may be dependent on factors such as ethnicity, gender, diet, vitamin D receptor (VDR) polymorphisms and sunlight exposure. Vitamin D 58-67 vitamin D receptor Homo sapiens 183-201 29209434-6 2017 The studies presented in this review suggest that whether vitamin D may have beneficial effects in disease course or not, may be dependent on factors such as ethnicity, gender, diet, vitamin D receptor (VDR) polymorphisms and sunlight exposure. Vitamin D 58-67 vitamin D receptor Homo sapiens 203-206 29127362-1 2017 The functional study of different mutations on vitamin D receptor (VDR) gene causing hereditary vitamin D-resistant rickets (HVDRR) remains limited. Vitamin D 47-56 vitamin D receptor Homo sapiens 67-70 28778755-7 2017 The activities of vitamin D are dependent on the vitamin D receptor (VDR), a member of the steroid nuclear receptor superfamily. Vitamin D 18-27 vitamin D receptor Homo sapiens 49-67 28778755-7 2017 The activities of vitamin D are dependent on the vitamin D receptor (VDR), a member of the steroid nuclear receptor superfamily. Vitamin D 18-27 vitamin D receptor Homo sapiens 69-72 28388281-1 2017 AIM: Vitamin D acts through the binding to the vitamin D receptor (VDR). Vitamin D 5-14 vitamin D receptor Homo sapiens 47-65 28388281-1 2017 AIM: Vitamin D acts through the binding to the vitamin D receptor (VDR). Vitamin D 5-14 vitamin D receptor Homo sapiens 67-70 28669880-7 2017 Biological actions of Vitamin D are mediated via its nuclear hormone receptor vitamin D receptor (VDR) and is found to regulate many genes. Vitamin D 22-31 vitamin D receptor Homo sapiens 78-96 28669880-7 2017 Biological actions of Vitamin D are mediated via its nuclear hormone receptor vitamin D receptor (VDR) and is found to regulate many genes. Vitamin D 22-31 vitamin D receptor Homo sapiens 98-101 28703134-1 2017 Vitamin D deficiency is prevalent in liver disease and vitamin D has been shown to decrease hepatic fibrosis through an anti-TGFbeta-1/SMAD3 effect mediated by the vitamin D receptor. Vitamin D 0-9 vitamin D receptor Homo sapiens 164-182 28407346-1 2017 Vitamin D and single nucleotide polymorphisms (SNPs) in vitamin D receptor (VDR) gene are potentially involved in the pathogenesis of bronchial asthma (BA); however, precise mechanisms by which vitamin D reduces the inflammation and the role of VDR SNPs in BA are not completely understood. Vitamin D 0-9 vitamin D receptor Homo sapiens 76-79 28407346-1 2017 Vitamin D and single nucleotide polymorphisms (SNPs) in vitamin D receptor (VDR) gene are potentially involved in the pathogenesis of bronchial asthma (BA); however, precise mechanisms by which vitamin D reduces the inflammation and the role of VDR SNPs in BA are not completely understood. Vitamin D 56-65 vitamin D receptor Homo sapiens 76-79 28407346-1 2017 Vitamin D and single nucleotide polymorphisms (SNPs) in vitamin D receptor (VDR) gene are potentially involved in the pathogenesis of bronchial asthma (BA); however, precise mechanisms by which vitamin D reduces the inflammation and the role of VDR SNPs in BA are not completely understood. Vitamin D 56-65 vitamin D receptor Homo sapiens 245-248 28703134-1 2017 Vitamin D deficiency is prevalent in liver disease and vitamin D has been shown to decrease hepatic fibrosis through an anti-TGFbeta-1/SMAD3 effect mediated by the vitamin D receptor. Vitamin D 55-64 vitamin D receptor Homo sapiens 164-182 29313597-3 2017 Since the antitumor actions of vitamin D are mediated primarily through the nuclear vitamin D receptor (VDR), the aim of the present study was to investigate vitamin D status in patients with pterygium and in control subjects, and VDR immunohistochemical expression in samples of pterygium and normal conjunctiva in order to evaluate a possible role of vitamin D pathway in the pathogenesis of the disease. Vitamin D 31-40 vitamin D receptor Homo sapiens 104-107 28665452-1 2017 BACKGROUND: The metabolism of vitamin D is complex, its receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 can influence vitamin D serum levels. Vitamin D 30-39 vitamin D receptor Homo sapiens 66-69 28665452-1 2017 BACKGROUND: The metabolism of vitamin D is complex, its receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 can influence vitamin D serum levels. Vitamin D 139-148 vitamin D receptor Homo sapiens 66-69 28665452-2 2017 The aim of this study was to investigate the relationship of the polymorphisms of VDR (ApaI and BsmI), CYP27B1 and CYP24A1 with serum vitamin D levels in both forms, 25(OH)D3 (circulating form) and 1,25(OH)2D3 (active form), in colorectal cancer (CRC) patients. Vitamin D 134-143 vitamin D receptor Homo sapiens 82-85 29313597-3 2017 Since the antitumor actions of vitamin D are mediated primarily through the nuclear vitamin D receptor (VDR), the aim of the present study was to investigate vitamin D status in patients with pterygium and in control subjects, and VDR immunohistochemical expression in samples of pterygium and normal conjunctiva in order to evaluate a possible role of vitamin D pathway in the pathogenesis of the disease. Vitamin D 84-93 vitamin D receptor Homo sapiens 104-107 29313597-3 2017 Since the antitumor actions of vitamin D are mediated primarily through the nuclear vitamin D receptor (VDR), the aim of the present study was to investigate vitamin D status in patients with pterygium and in control subjects, and VDR immunohistochemical expression in samples of pterygium and normal conjunctiva in order to evaluate a possible role of vitamin D pathway in the pathogenesis of the disease. Vitamin D 84-93 vitamin D receptor Homo sapiens 104-107 28330721-1 2017 Vitamin D is hydroxylated in the liver and kidneys to its active form, which can bind to the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 93-111 28976989-1 2017 BACKGROUND: Vitamin D associates with the plasma concentration of the endogenous inhibitor of the nitric oxide system asymmetric dimethyl arginine (ADMA) and cross-sectional studies in CKD patients treated with the vitamin D receptor activator paricalcitol show that plasma ADMA is substantially less than in those not receiving this drug. Vitamin D 12-21 vitamin D receptor Homo sapiens 215-233 28836398-11 2017 Although the individuals taking part in this study had normal levels of vitamin D, the increase in VDR expression levels may perhaps be a response to a defect in vitamin D processing. Vitamin D 162-171 vitamin D receptor Homo sapiens 99-102 28836398-13 2017 Of course, further studies are required to identify the mechanism of action of vitamin D by analyzing genes involved in its signaling pathway, particularly VDR and CYP24A1. Vitamin D 79-88 vitamin D receptor Homo sapiens 156-159 29062180-11 2017 VDR gene polymorphism was found to be associated with MFI cases as compared to controls and the serum level of vitamin D was also decreased in MFI cases than in controls (p value < 0.05). Vitamin D 111-120 vitamin D receptor Homo sapiens 0-3 27693422-0 2017 Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORalpha and RORgamma. Vitamin D 35-44 vitamin D receptor Homo sapiens 93-96 27693422-1 2017 The classical pathway of vitamin D activation follows the sequence D3 25(OH)D3 1,25(OH)2D3 with the final product acting on the receptor for vitamin D (VDR). Vitamin D 25-34 vitamin D receptor Homo sapiens 152-155 27693422-1 2017 The classical pathway of vitamin D activation follows the sequence D3 25(OH)D3 1,25(OH)2D3 with the final product acting on the receptor for vitamin D (VDR). Vitamin D 141-150 vitamin D receptor Homo sapiens 152-155 28954197-0 2017 Vitamin D Analogues with a p-Hydroxyphenyl Group at the C25 Position: Crystal Structure of Vitamin D Receptor Ligand-Binding Domain Complexed with the Ligand Explains the Mechanism Underlying Full Antagonistic Action. Vitamin D 0-9 vitamin D receptor Homo sapiens 91-109 28330721-1 2017 Vitamin D is hydroxylated in the liver and kidneys to its active form, which can bind to the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 113-116 27693422-13 2017 We suggest that the identification of large number of endogenously produced alternative hydroxy-metabolites of D3 that are biologically active, and of possible alternative receptors, may offer an explanation for the pleiotropic and diverse activities of vitamin D, previously assigned solely to 1,25(OH)2D3 and VDR. Vitamin D 254-263 vitamin D receptor Homo sapiens 311-314 27693423-2 2017 In recent years the spectrum of vitamin D target organs has expanded and a reproductive role is supported by the presence of the vitamin D receptor (VDR) and the vitamin D metabolizing enzymes in the gonads, reproductive tract, and human spermatozoa. Vitamin D 32-41 vitamin D receptor Homo sapiens 129-147 28843271-11 2017 Vitamin D stimulated the proliferation of the vaginal epithelium by activating p-RhoA and Erzin through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 108-126 27693423-2 2017 In recent years the spectrum of vitamin D target organs has expanded and a reproductive role is supported by the presence of the vitamin D receptor (VDR) and the vitamin D metabolizing enzymes in the gonads, reproductive tract, and human spermatozoa. Vitamin D 32-41 vitamin D receptor Homo sapiens 149-152 27693423-2 2017 In recent years the spectrum of vitamin D target organs has expanded and a reproductive role is supported by the presence of the vitamin D receptor (VDR) and the vitamin D metabolizing enzymes in the gonads, reproductive tract, and human spermatozoa. Vitamin D 129-138 vitamin D receptor Homo sapiens 149-152 27693423-8 2017 The VDR is ubiquitously expressed and activated vitamin D is a regulator of insulin, aromatase, and osteocalcin. Vitamin D 48-57 vitamin D receptor Homo sapiens 4-7 29034815-3 2017 Furthermore, there has been observed a relationship between serum vitamin D and testosterone concentrations in an elderly Caucasian population carrying the vitamin D receptor FokI gene polymorphism. Vitamin D 66-75 vitamin D receptor Homo sapiens 156-174 29022486-7 2017 However, further studies focusing on the vitamin D receptor variants and haplotypes effects on vitamin D and vitamin D receptor concentrations, activities, and functionalities are needed. Vitamin D 41-50 vitamin D receptor Homo sapiens 109-127 28843271-11 2017 Vitamin D stimulated the proliferation of the vaginal epithelium by activating p-RhoA and Erzin through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 128-131 28843271-12 2017 The results suggest that vitamin D positively regulates cell-to-cell junction by increasing the VDR/p-RhoA/p-Ezrin pathway. Vitamin D 25-34 vitamin D receptor Homo sapiens 96-99 28739397-1 2017 BACKGROUND: Data concerning the association of serum levels of vitamin D and metalloproteinases and vitamin D receptor gene polymorphism with coronary artery disease (CAD) is not fully demonstrated. Vitamin D 63-72 vitamin D receptor Homo sapiens 100-118 28579120-4 2017 Vitamin D signalling occurs via the vitamin D receptor (VDR), a zinc-finger protein in the nuclear receptor superfamily. Vitamin D 0-9 vitamin D receptor Homo sapiens 36-54 28579120-4 2017 Vitamin D signalling occurs via the vitamin D receptor (VDR), a zinc-finger protein in the nuclear receptor superfamily. Vitamin D 0-9 vitamin D receptor Homo sapiens 56-59 28579120-6 2017 The transcriptional activity of vitamin D occurs via the nuclear VDR. Vitamin D 32-41 vitamin D receptor Homo sapiens 65-68 28579120-8 2017 The VDR is present in the developing and adult brain where it mediates the effects of vitamin D on brain development and function. Vitamin D 86-95 vitamin D receptor Homo sapiens 4-7 28602863-5 2017 Vitamin D receptor number decreases with aging in several organs involved in calcium metabolism and 1alpha-hydroxylase activity decreases mainly due to a decrease in renal function reducing vitamin D activation. Vitamin D 190-199 vitamin D receptor Homo sapiens 0-18 28902929-9 2017 These results indicated that vitamin D concentrations in the decidua are associated with inflammatory cytokine production, suggesting that vitamin D and VDR may play a role in the etiology of RSA. Vitamin D 29-38 vitamin D receptor Homo sapiens 153-156 28257826-2 2017 Its synthesis and its metabolites, their transport and elimination as well as action on transcriptional regulation involves the harmonic cooperation of diverse proteins with vitamin D binding capacities such as vitamin D binding protein (DBP), cytochrome P450 enzymes or the nuclear vitamin receptor (VDR). Vitamin D 174-183 vitamin D receptor Homo sapiens 301-304 28257826-6 2017 Additionally, we will describe, the implications of the VDR mutants associated with hereditary vitamin D-resistant rickets (HVDRR) that display impaired function. Vitamin D 95-104 vitamin D receptor Homo sapiens 56-59 28315703-1 2017 The molecular endocrinology of vitamin D is based on the facts that i) its metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the high affinity ligand of the nuclear receptor vitamin D receptor (VDR) and ii) the transcription factor VDR is the unique target of 1,25(OH)2D3 in the nucleus. Vitamin D 31-40 vitamin D receptor Homo sapiens 202-205 28315703-1 2017 The molecular endocrinology of vitamin D is based on the facts that i) its metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the high affinity ligand of the nuclear receptor vitamin D receptor (VDR) and ii) the transcription factor VDR is the unique target of 1,25(OH)2D3 in the nucleus. Vitamin D 31-40 vitamin D receptor Homo sapiens 240-243 28315703-3 2017 Vitamin D has via VDR a direct effect on the expression of several hundred primary target genes implying numerous effects on the epigenome. Vitamin D 0-9 vitamin D receptor Homo sapiens 18-21 28342856-2 2017 The effects of vitamin D are mediated by the vitamin D receptor, which is expressed together with the vitamin D metabolizing enzymes in the reproductive tissues. Vitamin D 15-24 vitamin D receptor Homo sapiens 45-63 28526240-4 2017 Recent findings convincingly support the concept of a new function of the VDR as a tumor suppressor in skin, with key components of the vitamin D endocrine system, including VDR, CYP24A1, CYP27A1, and CYP27B1 being strongly expressed in non-melanoma skin cancer (NMSC). Vitamin D 136-145 vitamin D receptor Homo sapiens 74-77 28891930-4 2017 The effects of vitamin D and interaction with the VDR may be influenced by polymorphism in the VDR gene. Vitamin D 15-24 vitamin D receptor Homo sapiens 95-98 28578001-1 2017 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], acts as a ligand for the vitamin D receptor (VDR), and regulates various physiological processes, including calcium and bone metabolism, cellular growth and differentiation, immunity and cardiovascular function. Vitamin D 19-28 vitamin D receptor Homo sapiens 100-118 28944088-2 2017 The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D, 1,25-dihydroxy-vitamin D [1,25(OH)2D] are mediated through binding to the vitamin D receptor (VDR). Vitamin D 83-92 vitamin D receptor Homo sapiens 168-186 28944088-2 2017 The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D, 1,25-dihydroxy-vitamin D [1,25(OH)2D] are mediated through binding to the vitamin D receptor (VDR). Vitamin D 83-92 vitamin D receptor Homo sapiens 188-191 28944088-5 2017 These growth-retarding effects of VDR knockdown occur in the presence and absence of vitamin D and are independent of whether cells were grown in bone or soft tissues. Vitamin D 85-94 vitamin D receptor Homo sapiens 34-37 28710799-4 2017 Vitamin D plays an important role in glucose homeostasis and insulin secretion through transcriptional mechanisms mediated by its receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 140-143 28710799-7 2017 The aim of this study was to evaluate the effect of hyperglycemia on VDR OGlcNAcylation and its effects on vitamin D-mediated transcription. Vitamin D 107-116 vitamin D receptor Homo sapiens 69-72 28712921-1 2017 The transcription factor vitamin D receptor (VDR) is the exclusive nuclear target of the biologically active form of vitamin D (1,25(OH)2D3). Vitamin D 25-34 vitamin D receptor Homo sapiens 45-48 28712921-4 2017 Machine learning and statistical analysis as well as a comparison with the re-analyzed B cell VDR cistrome indicated a subgroup of 339 highly conserved persistent VDR sites that were suited best for describing vitamin D-triggered gene regulatory scenarios. Vitamin D 210-219 vitamin D receptor Homo sapiens 94-97 28712921-4 2017 Machine learning and statistical analysis as well as a comparison with the re-analyzed B cell VDR cistrome indicated a subgroup of 339 highly conserved persistent VDR sites that were suited best for describing vitamin D-triggered gene regulatory scenarios. Vitamin D 210-219 vitamin D receptor Homo sapiens 163-166 28712921-7 2017 The number of persistent and transient VDR sites was found to be the main discriminator for sorting these TADs into five classes carrying vitamin D target genes involved in distinct biological processes. Vitamin D 138-147 vitamin D receptor Homo sapiens 39-42 28712921-8 2017 In conclusion, specific regulation of biological processes by vitamin D depends on differences in time-dependent VDR binding. Vitamin D 62-71 vitamin D receptor Homo sapiens 113-116 28578001-1 2017 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], acts as a ligand for the vitamin D receptor (VDR), and regulates various physiological processes, including calcium and bone metabolism, cellular growth and differentiation, immunity and cardiovascular function. Vitamin D 19-28 vitamin D receptor Homo sapiens 120-123 28636886-1 2017 The hormonal metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), binds to the vitamin D receptor (VDR) and promotes heterodimerization of VDR with a retinoid-X-receptor (RXR) to genomically regulate diverse cellular processes. Vitamin D 27-36 vitamin D receptor Homo sapiens 85-103 28578001-4 2017 Our prior study has demonstrated that 1,25(OH)2D3 induces TRPV6 mRNA expression at lower concentrations than for induction of CYP24A1, a VDR target gene involved in vitamin D inactivation, in intestinal SW480 cells, suggesting an additional mechanism for vitamin D signaling on TRPV6 induction. Vitamin D 165-174 vitamin D receptor Homo sapiens 137-140 28636886-1 2017 The hormonal metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), binds to the vitamin D receptor (VDR) and promotes heterodimerization of VDR with a retinoid-X-receptor (RXR) to genomically regulate diverse cellular processes. Vitamin D 27-36 vitamin D receptor Homo sapiens 105-108 28636886-1 2017 The hormonal metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), binds to the vitamin D receptor (VDR) and promotes heterodimerization of VDR with a retinoid-X-receptor (RXR) to genomically regulate diverse cellular processes. Vitamin D 27-36 vitamin D receptor Homo sapiens 145-148 28835228-2 2017 In the present study we assess whether vitamin D supplementation, in the follow-up period after diagnosis and surgical resection of the primary tumor, has a protective effect on relapse of cutaneous malignant melanoma and whether this protective effect correlates with vitamin D levels in serum and Vitamin D Receptor immunoreactivity in the primary tumor. Vitamin D 39-48 vitamin D receptor Homo sapiens 299-317 28686349-1 2017 BACKGROUND: Previous studies have demonstrated that vitamin D affects T-cell function and maturation via the vitamin D receptor. Vitamin D 52-61 vitamin D receptor Homo sapiens 109-127 28070798-5 2017 Moreover, the expression of the vitamin D receptor (VDR) in these cells suggests a local action of vitamin D in the immune response. Vitamin D 32-41 vitamin D receptor Homo sapiens 52-55 28830368-1 2017 BACKGROUND: There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population. Vitamin D 68-77 vitamin D receptor Homo sapiens 203-206 28231625-1 2017 OBJECTIVE: To explore the protective function of vitamin D (VD)/vitamin D receptor (VDR) on the development of oral lichen planus (OLP) and elaborate the underling mechanism of it. Vitamin D 49-58 vitamin D receptor Homo sapiens 84-87 30258921-0 2017 Association of vitamin D receptor gene polymorphism (VDR) with vitamin D deficiency, metabolic and inflammatory markers in Egyptian obese women. Vitamin D 15-24 vitamin D receptor Homo sapiens 53-56 28601283-3 2017 The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3, has been shown to exert its immune modulatory properties through its nuclear receptor (VDR) namely by inhibiting the proliferation of Th cells. Vitamin D 32-41 vitamin D receptor Homo sapiens 156-159 28830368-1 2017 BACKGROUND: There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population. Vitamin D 68-77 vitamin D receptor Homo sapiens 208-226 28811597-2 2017 Thus, we studied the metabolic effects of a 12-month vitamin D supplementation in T2DM patients according to VDR polymorphisms. Vitamin D 53-62 vitamin D receptor Homo sapiens 109-112 28811597-10 2017 In conclusion, improvements in metabolic profile due to vitamin D supplementation is influenced by VDR polymorphisms, specifically for carriers of Taq-I GG and Bsm-I TT genotypes. Vitamin D 56-65 vitamin D receptor Homo sapiens 99-102 28811844-2 2017 Here, we demonstrate that LSD1 regulates vitamin D receptor (VDR) activity and is a mediator of 1,25(OH)2-D3 (vitamin D) action in prostate cancer (PCa). Vitamin D 41-50 vitamin D receptor Homo sapiens 61-64 28739681-1 2017 BACKGROUND: Vitamin D mediates its action via vitamin D receptor (VDR) and is involved in a wide variety of biological processes including regulation of cell proliferation and differentiation in normal tissue and apoptosis, and cell adhesion in tumor cells. Vitamin D 12-21 vitamin D receptor Homo sapiens 46-64 28739681-1 2017 BACKGROUND: Vitamin D mediates its action via vitamin D receptor (VDR) and is involved in a wide variety of biological processes including regulation of cell proliferation and differentiation in normal tissue and apoptosis, and cell adhesion in tumor cells. Vitamin D 12-21 vitamin D receptor Homo sapiens 66-69 28739681-2 2017 The study of genetic variations in VDR may elucidate the association of vitamin D levels, its metabolism, and VDR polymorphism with various diseases and cancer. Vitamin D 72-81 vitamin D receptor Homo sapiens 35-38 28955691-2 2017 Vitamin D has relevance to muscle and immune function, hypertension, diabetes mellitus, cancer, and pregnancy because vitamin D receptors (VDR) are present in many non-skeletal tissues. Vitamin D 0-9 vitamin D receptor Homo sapiens 118-137 28955691-2 2017 Vitamin D has relevance to muscle and immune function, hypertension, diabetes mellitus, cancer, and pregnancy because vitamin D receptors (VDR) are present in many non-skeletal tissues. Vitamin D 0-9 vitamin D receptor Homo sapiens 139-142 28955691-3 2017 Vitamin D acts on target tissues via the binding of its active form to VDR. Vitamin D 0-9 vitamin D receptor Homo sapiens 71-74 28786260-0 2017 Vitamin D and Autoimmune Diseases: Is Vitamin D Receptor (VDR) Polymorphism the Culprit? Vitamin D 0-9 vitamin D receptor Homo sapiens 38-56 28576565-0 2017 The expression of VDR mRNA but not NF-kappaB surprisingly decreased after vitamin D treatment in multiple sclerosis patients. Vitamin D 74-83 vitamin D receptor Homo sapiens 18-21 28576565-1 2017 BACKGROUND AND PURPOSE: The aim of this study was to investigate the expression levels of vitamin D receptor (VDR) and NF-kappaB mRNAs in vitamin D (VD) supplemented multiple sclerosis (MS) patients. Vitamin D 90-99 vitamin D receptor Homo sapiens 110-113 31149190-2 2017 Vitamin D action is mediated through vitamin D receptor (VDR), which acts as a transcription factor. Vitamin D 0-9 vitamin D receptor Homo sapiens 37-55 31149190-2 2017 Vitamin D action is mediated through vitamin D receptor (VDR), which acts as a transcription factor. Vitamin D 0-9 vitamin D receptor Homo sapiens 57-60 31149190-14 2017 Conclusion: The results provide new insights of Cdx-2 polymorphism is involved in vitamin D deficiency, highlighting the important role of epigenetic modification of vitamin D receptor and male infertility along with the genetic context. Vitamin D 82-91 vitamin D receptor Homo sapiens 166-184 28786260-0 2017 Vitamin D and Autoimmune Diseases: Is Vitamin D Receptor (VDR) Polymorphism the Culprit? Vitamin D 0-9 vitamin D receptor Homo sapiens 58-61 28367941-1 2017 Vitamin D-dependent rickets type 2A (VDDR2A) is a rare inherited disorder with decreased tissue responsiveness to 1,25-dihydroxyvitamin D [1,25(OH)2D], caused by loss of function mutations in the vitamin D receptor (VDR) gene. Vitamin D 0-9 vitamin D receptor Homo sapiens 196-214 28242261-2 2017 These physiological actions caused by vitamin D are triggered by the specific interaction between vitamin D receptor (VDR) and vitamin D. Vitamin D 38-47 vitamin D receptor Homo sapiens 98-116 28242261-2 2017 These physiological actions caused by vitamin D are triggered by the specific interaction between vitamin D receptor (VDR) and vitamin D. Vitamin D 38-47 vitamin D receptor Homo sapiens 118-121 28242261-2 2017 These physiological actions caused by vitamin D are triggered by the specific interaction between vitamin D receptor (VDR) and vitamin D. Vitamin D 98-107 vitamin D receptor Homo sapiens 118-121 28242261-3 2017 In the present study, we investigated the interactions between VDR and vitamin D derivatives using ab initio molecular simulation, in order to elucidate the reason for the significant difference in their effects on VDR activity. Vitamin D 71-80 vitamin D receptor Homo sapiens 63-66 28242261-3 2017 In the present study, we investigated the interactions between VDR and vitamin D derivatives using ab initio molecular simulation, in order to elucidate the reason for the significant difference in their effects on VDR activity. Vitamin D 71-80 vitamin D receptor Homo sapiens 215-218 28242261-5 2017 This finding will be helpful for proposing new vitamin D derivatives as a potent modulator or inhibitor against VDR. Vitamin D 47-56 vitamin D receptor Homo sapiens 112-115 28367941-1 2017 Vitamin D-dependent rickets type 2A (VDDR2A) is a rare inherited disorder with decreased tissue responsiveness to 1,25-dihydroxyvitamin D [1,25(OH)2D], caused by loss of function mutations in the vitamin D receptor (VDR) gene. Vitamin D 0-9 vitamin D receptor Homo sapiens 216-219 28617856-0 2017 The associations between VDR BsmI polymorphisms and risk of vitamin D deficiency, obesity and insulin resistance in adolescents residing in a tropical country. Vitamin D 60-69 vitamin D receptor Homo sapiens 25-28 28465245-8 2017 High levels of VDR in human gastric cancer tissues and cancer cell lines implicated that vitamin D could display more potent pharmacological action against malignant cells. Vitamin D 89-98 vitamin D receptor Homo sapiens 15-18 28617856-16 2017 CONCLUSION: VDR BsmI polymorphism was significantly associated with vitamin D deficiency and insulin resistance, but not with obesity in this population. Vitamin D 68-77 vitamin D receptor Homo sapiens 12-15 28617856-2 2017 The rs1544410 or BsmI single nucleotide polymorphism (SNP) in the intronic region of the VDR gene has been previously associated with vitamin D levels, obesity and insulin resistance. Vitamin D 134-143 vitamin D receptor Homo sapiens 89-92 28335003-3 2017 We investigated whether variation in binding of a transcription factor, the vitamin D receptor (VDR), whose activating ligand vitamin D has been proposed as a modifiable factor in multiple disorders, could explain any of these associations. Vitamin D 76-85 vitamin D receptor Homo sapiens 96-99 28335003-11 2017 Replicated VDR-BVs associated with these disorders could represent causal disease risk alleles whose effect may be modifiable by vitamin D levels. Vitamin D 129-138 vitamin D receptor Homo sapiens 11-14 28243735-2 2017 Mechanistic insights have given an explanation on how vitamin D exerts antineoplastic functions, which are mainly conducted via the canonical vitamin D receptor (VDR)-vitamin D response elements (VDRE) pathway. Vitamin D 54-63 vitamin D receptor Homo sapiens 142-160 28243735-2 2017 Mechanistic insights have given an explanation on how vitamin D exerts antineoplastic functions, which are mainly conducted via the canonical vitamin D receptor (VDR)-vitamin D response elements (VDRE) pathway. Vitamin D 54-63 vitamin D receptor Homo sapiens 162-165 28243735-2 2017 Mechanistic insights have given an explanation on how vitamin D exerts antineoplastic functions, which are mainly conducted via the canonical vitamin D receptor (VDR)-vitamin D response elements (VDRE) pathway. Vitamin D 142-151 vitamin D receptor Homo sapiens 162-165 29088772-1 2017 Vitamin D is an important modulator of cellular proliferation through the vitamin D receptor (VDR) that binds to DNA in the regulatory sequences of target genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 74-92 28615947-4 2017 Another important player in regulating mineral metabolism is vitamin D receptor (VDR), which is under the influence of vitamin D and influences the intestinal absorption of calcium and phosphate, PTH gene expression, and bone calcium mobilization. Vitamin D 61-70 vitamin D receptor Homo sapiens 81-84 28615947-6 2017 Current therapeutic approaches consist of 1) phosphate intake control by diet or phosphate binders, 2) vitamin D by VDR activation, and 3) calcimimetic agents that activate CaSR. Vitamin D 103-112 vitamin D receptor Homo sapiens 116-119 29088772-1 2017 Vitamin D is an important modulator of cellular proliferation through the vitamin D receptor (VDR) that binds to DNA in the regulatory sequences of target genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 94-97 28460457-2 2017 Vitamin D inhibits breast cancer growth through activation of the vitamin D receptor (VDR) and via classical nuclear signaling pathways. Vitamin D 0-9 vitamin D receptor Homo sapiens 66-84 28385183-3 2017 Due the important immune-modulating properties of Vitamin D, Vitamin D receptor (VDR) gene polymorphisms - which interfere with the actions of Vitamin D- could be related to increased risk of MS. METHODS: We studied 120 patients fulfilling the McDonald criteria for MS (81 females and 39 males) and 180 healthy unrelated controls, nested in a case-Control study, and were recruited from the National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez in Mexico City. Vitamin D 50-59 vitamin D receptor Homo sapiens 81-84 28385183-3 2017 Due the important immune-modulating properties of Vitamin D, Vitamin D receptor (VDR) gene polymorphisms - which interfere with the actions of Vitamin D- could be related to increased risk of MS. METHODS: We studied 120 patients fulfilling the McDonald criteria for MS (81 females and 39 males) and 180 healthy unrelated controls, nested in a case-Control study, and were recruited from the National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez in Mexico City. Vitamin D 61-70 vitamin D receptor Homo sapiens 81-84 28431765-4 2017 The immune-modulating effects appear to be mediated by vitamin D interaction with the vitamin D receptor (VDR) that has transcriptional effects and is expressed on various cell types, especially those of the immune system. Vitamin D 55-64 vitamin D receptor Homo sapiens 86-104 28431765-4 2017 The immune-modulating effects appear to be mediated by vitamin D interaction with the vitamin D receptor (VDR) that has transcriptional effects and is expressed on various cell types, especially those of the immune system. Vitamin D 55-64 vitamin D receptor Homo sapiens 106-109 28177523-2 2017 The vitamin D endocrine system regulates transcriptional programs involved in inflammation, cell growth and differentiation through the binding of vitamin D receptor (VDR) to specific VDR elements. Vitamin D 4-13 vitamin D receptor Homo sapiens 147-165 28177523-2 2017 The vitamin D endocrine system regulates transcriptional programs involved in inflammation, cell growth and differentiation through the binding of vitamin D receptor (VDR) to specific VDR elements. Vitamin D 4-13 vitamin D receptor Homo sapiens 167-170 28177523-2 2017 The vitamin D endocrine system regulates transcriptional programs involved in inflammation, cell growth and differentiation through the binding of vitamin D receptor (VDR) to specific VDR elements. Vitamin D 4-13 vitamin D receptor Homo sapiens 184-187 27584938-3 2017 We review the data that vitamin D, a pleiotropic hormone, is essential for Lgr5 stem cell functions by signaling through the vitamin D receptor. Vitamin D 24-33 vitamin D receptor Homo sapiens 125-143 27978548-2 2017 Objective: To investigate whether common variants in 7 vitamin D and calcium pathway genes (VDR, GC, DHCR7, CYP2R1, CYP27B1, CYP24A1, and CASR) modify the effects of vitamin D3 or calcium supplementation on colorectal adenoma recurrence. Vitamin D 55-64 vitamin D receptor Homo sapiens 92-95 28290237-16 2017 However, other data and the lack of trial evidence suggest that low vitamin D status is more likely the result of autoimmune disease processes that include vitamin D receptor dysfunction. Vitamin D 68-77 vitamin D receptor Homo sapiens 156-174 28206978-3 2017 Vitamin D not only maintains calcium and bone homeostasis, but also mostly inhibits tumor genesis, invasion, and metastasis through activation of vitamin D receptor. Vitamin D 0-9 vitamin D receptor Homo sapiens 146-164 28009432-1 2017 INTRODUCTION: Vitamin D receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 involved in the production and inactivation of vitamin D can influence vitamin D and the susceptibility to colorectal cancer (CRC). Vitamin D 140-149 vitamin D receptor Homo sapiens 14-32 28009432-1 2017 INTRODUCTION: Vitamin D receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 involved in the production and inactivation of vitamin D can influence vitamin D and the susceptibility to colorectal cancer (CRC). Vitamin D 140-149 vitamin D receptor Homo sapiens 34-37 28009432-1 2017 INTRODUCTION: Vitamin D receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 involved in the production and inactivation of vitamin D can influence vitamin D and the susceptibility to colorectal cancer (CRC). Vitamin D 164-173 vitamin D receptor Homo sapiens 14-32 28009432-1 2017 INTRODUCTION: Vitamin D receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 involved in the production and inactivation of vitamin D can influence vitamin D and the susceptibility to colorectal cancer (CRC). Vitamin D 164-173 vitamin D receptor Homo sapiens 34-37 31084485-3 2017 The aim of this study is to explore the associations between vitamin D (FOKI) receptor gene polymorphism (VDR) and vitamin D deficiency (VDD) and chronic musculoskeletal pain. Vitamin D 61-70 vitamin D receptor Homo sapiens 106-109 28425954-6 2017 We find a majority of association studies confirming a predisposing role for vitamin D receptor (VDR) polymorphisms and those of the vitamin D metabolism, particularly the CYP27B1 gene encoding the main enzyme for vitamin D activation. Vitamin D 77-86 vitamin D receptor Homo sapiens 97-100 28460457-2 2017 Vitamin D inhibits breast cancer growth through activation of the vitamin D receptor (VDR) and via classical nuclear signaling pathways. Vitamin D 0-9 vitamin D receptor Homo sapiens 86-89 28460457-10 2017 This new mechanism of VDR action in breast cancer cells contrasts the known anti-proliferative nuclear actions of the VDR-vitamin D ligand complex. Vitamin D 122-131 vitamin D receptor Homo sapiens 22-25 28460457-10 2017 This new mechanism of VDR action in breast cancer cells contrasts the known anti-proliferative nuclear actions of the VDR-vitamin D ligand complex. Vitamin D 122-131 vitamin D receptor Homo sapiens 118-121 28232093-0 2017 Epigenomic PU.1-VDR crosstalk modulates vitamin D signaling. Vitamin D 40-49 vitamin D receptor Homo sapiens 16-19 28301319-1 2017 BACKGROUND: Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disorder caused by mutations in the vitamin D receptor (VDR) gene. Vitamin D 23-32 vitamin D receptor Homo sapiens 121-139 28325259-2 2017 Following binding of the active form of vitamin D, i.e., 1,25(OH)2D3 (also known as calcitriol) and interaction with co-activators and co-repressors, VDR regulates the expression of several different genes. Vitamin D 40-49 vitamin D receptor Homo sapiens 150-153 28325259-3 2017 Although relatively little work has been carried out on VDR in human cancers, several epidemiological studies suggest that low circulating levels of vitamin D are associated with both an increased risk of developing specific cancer types and poor outcome in patients with specific diagnosed cancers. Vitamin D 149-158 vitamin D receptor Homo sapiens 56-59 28301319-1 2017 BACKGROUND: Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disorder caused by mutations in the vitamin D receptor (VDR) gene. Vitamin D 23-32 vitamin D receptor Homo sapiens 53-56 28296915-6 2017 Thirteen SNPs derived from vitamin D cascade-related genes, including DHCR7 (rs12785878), CYP27B1 (rs10877012), CYP2R1 (rs2060793, rs12794714), GC (rs4588, rs7041, rs222020, rs2282679), and VDR (FokI, BsmI, Tru9I, ApaI, TaqI), were genotyped. Vitamin D 27-36 vitamin D receptor Homo sapiens 190-193 28355272-3 2017 In order to identify potential mechanisms underlying vitamin D effects in MS, we profiled epigenetic changes in vitamin D receptor (VDR) gene to identify genomic regulatory elements relevant to MS pathogenesis. Vitamin D 53-62 vitamin D receptor Homo sapiens 112-130 28355272-3 2017 In order to identify potential mechanisms underlying vitamin D effects in MS, we profiled epigenetic changes in vitamin D receptor (VDR) gene to identify genomic regulatory elements relevant to MS pathogenesis. Vitamin D 53-62 vitamin D receptor Homo sapiens 132-135 28325820-1 2017 Vitamin D receptor represses basal autophagy in breast tissue, which is derepressed by vitamin D, slowing cancer progression. Vitamin D 87-96 vitamin D receptor Homo sapiens 0-18 27043843-1 2017 Vitamin D deficiency and/or reduced function, as per certain polymorphisms of the vitamin D receptor (VDR) gene, have been related to several autoimmune disorders. Vitamin D 0-9 vitamin D receptor Homo sapiens 82-100 28068558-1 2017 This study aimed to discover genetic variants in the entire 101 kB vitamin D receptor (VDR) gene for vitamin D deficiency in a group of postmenopausal Filipino women using targeted next generation sequencing (TNGS) approach in a case-control study design. Vitamin D 67-76 vitamin D receptor Homo sapiens 87-90 28068558-9 2017 These findings show the power of TNGS in identifying sequence variations in a very large gene and the surprising results obtained in this study greatly expand the catalog of known VDR sequence variants that may represent an important clue in the emergence of vitamin D deficiency. Vitamin D 259-268 vitamin D receptor Homo sapiens 180-183 27864003-0 2017 Novel screening system for high-affinity ligand of heredity vitamin D-resistant rickets-associated vitamin D receptor mutant R274L using bioluminescent sensor. Vitamin D 60-69 vitamin D receptor Homo sapiens 99-117 27864003-1 2017 Hereditary vitamin D-resistant rickets (HVDRR) is caused by mutations in the vitamin D receptor (VDR) gene. Vitamin D 11-20 vitamin D receptor Homo sapiens 77-95 27864003-1 2017 Hereditary vitamin D-resistant rickets (HVDRR) is caused by mutations in the vitamin D receptor (VDR) gene. Vitamin D 11-20 vitamin D receptor Homo sapiens 41-44 27864003-7 2017 Of the 33 vitamin D analogs, 5 showed much higher affinities for the mutant VDR (R274L) than 1alpha,25(OH)2D3, and 2alpha-[2-(tetrazol-2-yl)ethyl]-1alpha,25-(OH)2D3 showed the highest affinity. Vitamin D 10-19 vitamin D receptor Homo sapiens 76-79 28242709-4 2017 Activation of the VDR by vitamin D induces autophagy and an autophagic transcriptional signature in BC cells that correlates with increased survival in patients; strikingly, this signature is present in the normal mammary gland and is progressively lost in patients with metastatic BC. Vitamin D 25-34 vitamin D receptor Homo sapiens 18-21 27977320-1 2017 Context: The vitamin D receptor (VDR) and enzymes involved in activation (CYP2R1, CYP27B1) and inactivation (CYP24A1) of vitamin D are expressed in ovary, testes, and spermatozoa. Vitamin D 13-22 vitamin D receptor Homo sapiens 33-36 27043843-1 2017 Vitamin D deficiency and/or reduced function, as per certain polymorphisms of the vitamin D receptor (VDR) gene, have been related to several autoimmune disorders. Vitamin D 0-9 vitamin D receptor Homo sapiens 102-105 28163705-3 2016 In the context of autoimmune diseases, this is illustrated by correlations of vitamin D status and genetic polymorphisms in the vitamin D receptor with the incidence and severity of the disease. Vitamin D 78-87 vitamin D receptor Homo sapiens 128-146 28031008-4 2017 RESULTS: Genetic vitamin D receptor (VDR) polymorphisms and other VDR biology regulation are involved in predisposition to gastrointestinal cancers and might allow tailored strategies for managing those individuals especially at risk, e.g. through vitamin D supplementation. Vitamin D 17-26 vitamin D receptor Homo sapiens 37-40 27407090-2 2017 Vitamin D receptor (VDR) is central for vitamin D-mediated transcription regulation. Vitamin D 40-49 vitamin D receptor Homo sapiens 0-18 27407090-2 2017 Vitamin D receptor (VDR) is central for vitamin D-mediated transcription regulation. Vitamin D 40-49 vitamin D receptor Homo sapiens 20-23 27407090-10 2017 The present findings of VDR expression are consistent with our previous results of circulating vitamin D biomarkers, which provide two converging lines of evidence supporting the putative benefits of vitamin D against aggressive breast cancer. Vitamin D 200-209 vitamin D receptor Homo sapiens 24-27 27855629-2 2017 Through its nuclear receptor, VDR, vitamin D controls gene expression through genetic and epigenetic mechanisms. Vitamin D 35-44 vitamin D receptor Homo sapiens 30-33 27856242-2 2017 Vitamin D signaling through vitamin D receptor (VDR) exerts anti-proliferative and anti-inflammatory actions. Vitamin D 0-9 vitamin D receptor Homo sapiens 28-46 27856242-2 2017 Vitamin D signaling through vitamin D receptor (VDR) exerts anti-proliferative and anti-inflammatory actions. Vitamin D 0-9 vitamin D receptor Homo sapiens 48-51 29074824-2 2017 Vitamin D endocrine system is required for bone and mineral homeostasis through the active form of vitamin D[1alpha,25(OH)2D3]transported to the target organs, where the vitamin D receptor(VDR)is present. Vitamin D 0-9 vitamin D receptor Homo sapiens 170-188 29074824-2 2017 Vitamin D endocrine system is required for bone and mineral homeostasis through the active form of vitamin D[1alpha,25(OH)2D3]transported to the target organs, where the vitamin D receptor(VDR)is present. Vitamin D 0-9 vitamin D receptor Homo sapiens 189-192 29074824-2 2017 Vitamin D endocrine system is required for bone and mineral homeostasis through the active form of vitamin D[1alpha,25(OH)2D3]transported to the target organs, where the vitamin D receptor(VDR)is present. Vitamin D 99-108 vitamin D receptor Homo sapiens 170-188 29074824-2 2017 Vitamin D endocrine system is required for bone and mineral homeostasis through the active form of vitamin D[1alpha,25(OH)2D3]transported to the target organs, where the vitamin D receptor(VDR)is present. Vitamin D 99-108 vitamin D receptor Homo sapiens 189-192 29074824-3 2017 The biological significance of 1alpha,25(OH)2D3-VDR signalling is regarded not only in classical target of vitamin D involved in calcium and phosphate homeostasis, such as intestine, bone, kidney and parathyroid glands, but also in many other non-classical target cells of vitamin D including skin keratinocytes, pancreatic beta cells, cardiomyocytes, T-lymphocytes, bone marrow macrophages, among others. Vitamin D 107-116 vitamin D receptor Homo sapiens 48-51 29074824-3 2017 The biological significance of 1alpha,25(OH)2D3-VDR signalling is regarded not only in classical target of vitamin D involved in calcium and phosphate homeostasis, such as intestine, bone, kidney and parathyroid glands, but also in many other non-classical target cells of vitamin D including skin keratinocytes, pancreatic beta cells, cardiomyocytes, T-lymphocytes, bone marrow macrophages, among others. Vitamin D 273-282 vitamin D receptor Homo sapiens 48-51 29074824-4 2017 Although 1alpha,25(OH)2D3-VDR signalling in classical target organs of vitamin D has been extensively studied, its precise function in these target organs still needs further investigation. Vitamin D 71-80 vitamin D receptor Homo sapiens 26-29 29074825-6 2017 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3[1,25(OH)2D3], acts as a physiological VDR ligand, and regulates various physiological processes, including calcium and bone metabolism, cellular growth and differentiation, immunity, and cardiovascular function. Vitamin D 19-28 vitamin D receptor Homo sapiens 98-101 28787727-5 2017 Using candidate gene approach, obesity- (insulin-like growth factor 2 (IGF2), proopiomelanocortin (POMC)) and vitamin D metabolism-related genes (1-alfa-hydroxylase (CYP27B1), VDR) regulated by DNA methylation were selected. Vitamin D 110-119 vitamin D receptor Homo sapiens 176-179 27320333-5 2017 Conversely, RXR is able to form "nonpermissive" heterodimers with vitamin D receptor (VDR), thyroid receptor (TR) and retinoic acid receptor (RAR), which function only in the presence of vitamin D, T3 and retinoic acid, respectively. Vitamin D 66-75 vitamin D receptor Homo sapiens 86-89 29264978-3 2017 Among the hypotheses of menstrual dysfunction with vitamin D deficiency, neurohumoral regulation of the hypothalamic-pituitary-ovarian system is considered to be essential due to the localization of vitamin D receptors (VDR), unlike other vitamins, in the nuclei of various tissues and organs. Vitamin D 51-60 vitamin D receptor Homo sapiens 199-218 29333433-1 2017 Background: The vitamin D receptor (VDR) gene regulates insulin secretion from the pancreas and acts as a mediator of the immune response through vitamin D. Vitamin D 16-25 vitamin D receptor Homo sapiens 36-39 29333433-2 2017 Polymorphism in VDR causes alterations in the functioning of vitamin D, leading to type 1 diabetes (T1D) predisposition. Vitamin D 61-70 vitamin D receptor Homo sapiens 16-19 27922682-1 2017 Active vitamin D has several antitumor effects, including prodifferentiative, antiproliferative and proapoptotic functions in a number of tissues via its binding to vitamin D receptor. Vitamin D 7-16 vitamin D receptor Homo sapiens 165-183 27927849-4 2017 This is mainly due to the fact that gonadal function may be altered by vitamin D deficiency, as observed by the expression of vitamin D receptor mRNA in human ovaries, mixed ovarian cell cultures and granulosa cell cultures. Vitamin D 71-80 vitamin D receptor Homo sapiens 126-144 28013309-1 2017 BACKGROUND: Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disorder characterized by the early onset of rickets and is caused by mutations in the vitamin D receptor (VDR) gene. Vitamin D 23-32 vitamin D receptor Homo sapiens 172-190 28013309-1 2017 BACKGROUND: Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disorder characterized by the early onset of rickets and is caused by mutations in the vitamin D receptor (VDR) gene. Vitamin D 23-32 vitamin D receptor Homo sapiens 53-56 28978869-2 2017 We investigated their possible association with vitamin D receptor (VDR) FOK1 polymorphisms (rs10735810) and dietary parameters such as calcium and vitamin D intake. Vitamin D 48-57 vitamin D receptor Homo sapiens 68-71 28058015-8 2016 RESULTS: The active form of vitamin D, 1,25D3, showed enhanced VDR-mediated Atg16L1 mRNA expression, membranous Atg16L1 protein expression leading to enhanced autophagic LC3II protein expression and LC3 punctae in Salmonella-infected Caco-2 cells which was counteracted by Atg16L1 and VDR siRNA, but Atg16L1 mediated suppression of IL-1beta expression. Vitamin D 28-37 vitamin D receptor Homo sapiens 63-66 28058015-8 2016 RESULTS: The active form of vitamin D, 1,25D3, showed enhanced VDR-mediated Atg16L1 mRNA expression, membranous Atg16L1 protein expression leading to enhanced autophagic LC3II protein expression and LC3 punctae in Salmonella-infected Caco-2 cells which was counteracted by Atg16L1 and VDR siRNA, but Atg16L1 mediated suppression of IL-1beta expression. Vitamin D 28-37 vitamin D receptor Homo sapiens 285-288 30695614-0 2017 [The study of the association between rs2228570 polymorphism of VDR gene and vitamin D blood serum concentration in the inhabitants of the Russian Arctic]. Vitamin D 77-86 vitamin D receptor Homo sapiens 64-67 30695614-2 2017 The aim of this study was to evaluate the possible association between VDR FokI polymorphism and vitamin D sufficiency in the population of the Yamal-Nenets Autonomous District of the Russian Federation. Vitamin D 97-106 vitamin D receptor Homo sapiens 71-74 30695614-12 2017 Thus, the association between C allele presence of rs2228570 polymorphism of VDR gene and a deficiency of vitamin D (reduced levels of 25 (OH)D in blood serum) has been revealed. Vitamin D 106-115 vitamin D receptor Homo sapiens 77-80 27161894-13 2016 CONCLUSIONS: Restoration of vitamin D status of patients undergoing dialysis promoted upregulation of CYP27B1 and VDR expression in monocytes and a decrease in circulating inflammatory markers. Vitamin D 28-37 vitamin D receptor Homo sapiens 114-117 29634094-1 2016 The pleiotropism of vitamin D is due to the presence of vitamin D receptor in the cells of nearly all tissues and organs within the human body, including the CNS. Vitamin D 20-29 vitamin D receptor Homo sapiens 56-74 27902451-3 2016 Furthermore, in recent years it has been discovered that the vitamin D receptor (VDR) is widely distributed in many organs and tissues where vitamin D can perform other actions that include the modulation of the immune response, insulin secretion, anti-proliferative effect on cells of vascular smooth muscle, modulation of the renin-angiotensin-aldosterone system and regulates cell growth in several organs. Vitamin D 61-70 vitamin D receptor Homo sapiens 81-84 27420410-0 2016 Evaluation of the correlation between serum levels of vitamin D and vitamin D receptor gene polymorphisms in an Egyptian population. Vitamin D 54-63 vitamin D receptor Homo sapiens 68-86 27895321-4 2016 The purpose of this study was to assess the relation between levels of vitamin D receptor (VDR) gene expression and serum vitamin D with NP. Vitamin D 71-80 vitamin D receptor Homo sapiens 91-94 29634094-12 2016 Vitamin D is worth consideration since by inducing the expression of VDR gene it leads, among others, to the silencing of the transcription of the gene encoding the AOAPP and thus inhibits its cleavage into peptides that form amyloid deposits. Vitamin D 0-9 vitamin D receptor Homo sapiens 69-72 27569350-6 2016 A self-organizing map approach subdivided the vitamin D-sensitive CTCF sites into seven classes that can be distinguished by participation in DNA loop formation, binding to open chromatin, carrying binding motifs for CTCF or its relative BORIS, overlap with transcription start site (TSS) regions and binding of VDR. Vitamin D 46-55 vitamin D receptor Homo sapiens 312-315 27454349-6 2016 Expert opinion: There is an increasing appreciation of the impact of vitamin D and its receptor VDR not only in bone biology, but also for metabolic diseases, immunological disorders, and cancer. Vitamin D 69-78 vitamin D receptor Homo sapiens 96-99 27393303-0 2016 Nonspecific binding of a frequently used vitamin D receptor (VDR) antibody: important implications for vitamin D research in human health. Vitamin D 41-50 vitamin D receptor Homo sapiens 61-64 27716192-0 2016 Sequence analysis of four vitamin D family genes (VDR, CYP24A1, CYP27B1 and CYP2R1) in Vogt-Koyanagi-Harada (VKH) patients: identification of a potentially pathogenic variant in CYP2R1. Vitamin D 26-35 vitamin D receptor Homo sapiens 50-53 26686945-3 2016 We therefore conducted a literature review to identify reports of statistically significant associations between single nucleotide polymorphisms (SNP) in 11 vitamin D pathway genes (DHCR7, CYP2R1, CYP3A4, CYP27A1, DBP, LRP2, CUB, CYP27B1, CYP24A1, VDR and RXRA) and non-bone health outcomes and circulating levels of 25-hydroxyvitamin D (25[OH]D and 1,25-dihydroxyvitamin D (1,25[OH]2D). Vitamin D 157-166 vitamin D receptor Homo sapiens 248-251 27736940-2 2016 Polymorphisms in the gene encoding vitamin D receptor (VDR), which mediates most of the known cellular effects of vitamin D, have been suggested to alter this association. Vitamin D 35-44 vitamin D receptor Homo sapiens 55-58 27535015-3 2016 Polymorphisms in vitamin D receptor (VDR) gene can influence the expression of vitamin D in individuals. Vitamin D 17-26 vitamin D receptor Homo sapiens 37-40 27741157-2 2016 Vitamin D acts by binding to the vitamin D receptor, which is present in a variety of tissues; for this reason it is considered a hormone. Vitamin D 0-9 vitamin D receptor Homo sapiens 33-51 26523676-2 2016 The biologically active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3), serves as a ligand of the nuclear receptor vitamin D receptor (VDR). Vitamin D 32-41 vitamin D receptor Homo sapiens 151-154 26523676-6 2016 Primary and secondary vitamin D target genes being up- and down-regulated were related to changes in the epigenome of THP-1 cells, such as 1,25(OH)2D3-dependent chromatin opening and modulation of the genome-wide association of the transcription factors VDR and CCCTC-binding factor (CTCF) with their respective genomic binding sites. Vitamin D 22-31 vitamin D receptor Homo sapiens 254-257 27803671-3 2016 The active vitamin D metabolite, 1,25-dihydroxyvitamin D3 (1,25D3), bound to its receptor, the vitamin D receptor (VDR) regulates the expression of hundreds of different genes in a cell- and tissue-specific manner. Vitamin D 11-20 vitamin D receptor Homo sapiens 95-113 27803671-3 2016 The active vitamin D metabolite, 1,25-dihydroxyvitamin D3 (1,25D3), bound to its receptor, the vitamin D receptor (VDR) regulates the expression of hundreds of different genes in a cell- and tissue-specific manner. Vitamin D 11-20 vitamin D receptor Homo sapiens 115-118 27222384-7 2016 Vitamin D receptor gene silencing blocked this synergistic effect of vitamin D and TGFbeta1 on both collagen production and myofibroblast differentiation. Vitamin D 69-78 vitamin D receptor Homo sapiens 0-18 27435264-9 2016 In conclusion, MDD inactivates vitamin D signaling via both disruption of VDR-PGC1alpha interaction and sequestration of nuclear VDR attributable to HSP90 overexpression. Vitamin D 31-40 vitamin D receptor Homo sapiens 74-77 27435264-9 2016 In conclusion, MDD inactivates vitamin D signaling via both disruption of VDR-PGC1alpha interaction and sequestration of nuclear VDR attributable to HSP90 overexpression. Vitamin D 31-40 vitamin D receptor Homo sapiens 129-132 26869016-2 2016 The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes. Vitamin D 15-24 vitamin D receptor Homo sapiens 61-79 26869016-2 2016 The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes. Vitamin D 15-24 vitamin D receptor Homo sapiens 81-84 27475231-1 2016 Vitamin D supplementation in humans should be accompanied by calcium administration to avoid bone demineralization through vitamin D receptor signaling. Vitamin D 0-9 vitamin D receptor Homo sapiens 123-141 27450565-3 2016 To directly examine this signaling relationship, in the present study we have over-expressed the vitamin D receptor (VDR) in neuroblastoma SH-SY5Y cells in order to examine the mechanisms by which the active vitamin D hormone, 1,25(OH)2D3, via its receptor VDR, affects DA production and turnover. Vitamin D 97-106 vitamin D receptor Homo sapiens 117-120 27669215-13 2016 In summary, the results suggested that the lower the distribution of vitamin D concentration, the more the genetic variations in CYP24A1, VDR and GC genes may be associated with NSCLC risk. Vitamin D 69-78 vitamin D receptor Homo sapiens 138-141 27703587-2 2016 Vitamin D plays an important role in immune system through Vitamin D Receptors (VDR), which are transcription factors located abundantly in the body. Vitamin D 0-9 vitamin D receptor Homo sapiens 59-78 27703587-2 2016 Vitamin D plays an important role in immune system through Vitamin D Receptors (VDR), which are transcription factors located abundantly in the body. Vitamin D 0-9 vitamin D receptor Homo sapiens 80-83 27595605-1 2016 BACKGROUND: The vitamin D receptor (VDR) mediates the immunological function of vitamin D3, which activates macrophages, and vitamin D deficiency has been linked to tuberculosis risk. Vitamin D 16-25 vitamin D receptor Homo sapiens 36-39 27595605-2 2016 Single nucleotide polymorphisms (SNPs) in VDR may influence the function of vitamin D and susceptibility to tuberculosis. Vitamin D 76-85 vitamin D receptor Homo sapiens 42-45 26869016-2 2016 The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes. Vitamin D 15-24 vitamin D receptor Homo sapiens 174-177 27686292-1 2016 OBJECTIVE: To compare the pattern of Vitamin D receptor (VDR) polymorphisms (Apa I and Fok I) in Type I Diabetes mellitus (T1DM) as cases vs healthy population as control and to investigate the association of VDR polymorphism with vitamin D levels in cases and controls. Vitamin D 231-240 vitamin D receptor Homo sapiens 37-55 27174721-1 2016 BACKGROUND: Vitamin D is a chemopreventive agent that acts against colorectal carcinogenesis in vivo and in vitro through vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 122-140 27174721-1 2016 BACKGROUND: Vitamin D is a chemopreventive agent that acts against colorectal carcinogenesis in vivo and in vitro through vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 142-145 27211082-10 2016 CONCLUSION: Calcium plus vitamin D supplementation during pregnancy interacted with polymorphisms in the VDR gene promoter region affecting postpartum bone loss. Vitamin D 25-34 vitamin D receptor Homo sapiens 105-108 27358421-1 2016 BACKGROUND: The biological actions of vitamin D are mediated through the vitamin D receptor (VDR). Vitamin D 38-47 vitamin D receptor Homo sapiens 73-91 27570856-11 2016 CONCLUSION: The presence of GG allele of the SNP rs2228570 of VDR gene, SNPs rs4588 of GC gene and CYP2R1 rs10741657 gene was associated with vitamin D deficiency. Vitamin D 142-151 vitamin D receptor Homo sapiens 62-65 27530414-5 2016 In this study, we investigated the presence of vitamin D machinery and metabolism in ADMSCs by analyzing the expression levels of vitamin D receptor (VDR), vitamin D metabolizing enzymes (CYP24A1 and CYP27B1) after in vitro stimulation with active vitamin D, calcitriol. Vitamin D 47-56 vitamin D receptor Homo sapiens 130-148 27530414-5 2016 In this study, we investigated the presence of vitamin D machinery and metabolism in ADMSCs by analyzing the expression levels of vitamin D receptor (VDR), vitamin D metabolizing enzymes (CYP24A1 and CYP27B1) after in vitro stimulation with active vitamin D, calcitriol. Vitamin D 47-56 vitamin D receptor Homo sapiens 150-153 28164608-1 2016 BACKGROUND: The actions of Vitamin D in different tissues, including breast tissue, are mediated by vitamin D receptor (VDR). Vitamin D 27-36 vitamin D receptor Homo sapiens 100-118 28164608-1 2016 BACKGROUND: The actions of Vitamin D in different tissues, including breast tissue, are mediated by vitamin D receptor (VDR). Vitamin D 27-36 vitamin D receptor Homo sapiens 120-123 27217488-3 2016 Given the importance of the brain in controlling both glucose levels and body weight, we hypothesized that activation of central VDR links vitamin D to the regulation of glucose and energy homeostasis. Vitamin D 139-148 vitamin D receptor Homo sapiens 129-132 27217488-4 2016 Indeed, we found that small doses of active vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25D3) (calcitriol), into the third ventricle of the brain improved glucose tolerance and markedly increased hepatic insulin sensitivity, an effect that is dependent upon VDR within the paraventricular nucleus of the hypothalamus. Vitamin D 44-53 vitamin D receptor Homo sapiens 258-261 27345382-12 2016 Further investigations of the VDR and its relationship with PD are required to identify the role of vitamin D in the pathogenesis of PD. Vitamin D 100-109 vitamin D receptor Homo sapiens 30-33 27536155-1 2016 INTRODUCTION: Since there is evidence of the action of vitamin D as a modulator of insulin release and atherosclerosis, it may well be that the vitamin D receptor polymorphisms are associated with diabetes and its chronic complications. Vitamin D 55-64 vitamin D receptor Homo sapiens 144-162 28164608-2 2016 Vitamin D has antitumor functions in the body; any changes in VDR expression can therefore affect the anticancer activities of Vitamin D. Vitamin D 127-136 vitamin D receptor Homo sapiens 62-65 27125758-0 2016 Relationship between cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects: Cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects. Vitamin D 46-55 vitamin D receptor Homo sapiens 92-95 27125758-0 2016 Relationship between cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects: Cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects. Vitamin D 169-178 vitamin D receptor Homo sapiens 92-95 27125758-1 2016 This study aimed to evaluate the relationship between the cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects. Vitamin D 83-92 vitamin D receptor Homo sapiens 129-132 27128845-0 2016 Molecular assessment of vitamin D receptor polymorphism as a valid predictor to the response of interferon/ribavirin-based therapy in Egyptian patients with chronic hepatitis C. OBJECTIVE: The aim of this study was to find an association between serum concentration of vitamin D and vitamin D receptor (VDR) polymorphisms to achieve a sustained virological response (SVR). Vitamin D 24-33 vitamin D receptor Homo sapiens 283-301 27128845-0 2016 Molecular assessment of vitamin D receptor polymorphism as a valid predictor to the response of interferon/ribavirin-based therapy in Egyptian patients with chronic hepatitis C. OBJECTIVE: The aim of this study was to find an association between serum concentration of vitamin D and vitamin D receptor (VDR) polymorphisms to achieve a sustained virological response (SVR). Vitamin D 24-33 vitamin D receptor Homo sapiens 303-306 27358421-1 2016 BACKGROUND: The biological actions of vitamin D are mediated through the vitamin D receptor (VDR). Vitamin D 38-47 vitamin D receptor Homo sapiens 93-96 27471592-2 2016 The regulation of transcellular calcium transport by 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3, the active form of vitamin D) has been confirmed in humans and rodents, and regulators, including vitamin D receptor (VDR), calcium binding protein D9k (calbindin-D9k), plasma membrane Ca(2+)-ATPase 1b (PMCA1b), PMAC2b and Orai1, are involved in this process. Vitamin D 67-76 vitamin D receptor Homo sapiens 211-214 27338176-1 2016 OBJECTIVE: Vitamin D acts through vitamin D receptor (VDR) and has promising beneficial effects in the development and progression of multiple sclerosis (MS). Vitamin D 11-20 vitamin D receptor Homo sapiens 34-52 27338176-1 2016 OBJECTIVE: Vitamin D acts through vitamin D receptor (VDR) and has promising beneficial effects in the development and progression of multiple sclerosis (MS). Vitamin D 11-20 vitamin D receptor Homo sapiens 54-57 27785354-3 2016 The functional activity of vitamin D is dependent on the genotype of the vitamin D receptor (VDR) polymorphic genes. Vitamin D 27-36 vitamin D receptor Homo sapiens 73-91 27785354-3 2016 The functional activity of vitamin D is dependent on the genotype of the vitamin D receptor (VDR) polymorphic genes. Vitamin D 27-36 vitamin D receptor Homo sapiens 93-96 27294600-1 2016 To develop strong vitamin D receptor (VDR) antagonists and reveal their antagonistic mechanism, we designed and synthesized vitamin D analogues with bulky side chains based on the "active antagonist" concept in which antagonist prevents helix 12 (H12) folding. Vitamin D 18-27 vitamin D receptor Homo sapiens 38-41 27154546-2 2016 Vitamin D-dependent rickets type II (VDDRII) is a congenital disease caused by inactivating mutations in the VDR The condition is treated with high doses of calcitriol, but the therapeutic effects of other synthetic VD3 analogs have not yet been investigated. Vitamin D 0-9 vitamin D receptor Homo sapiens 109-112 27327272-0 2016 Profiling of Vitamin D Metabolic Intermediates toward VDR Using Novel Stable Gene Reporter Cell Lines IZ-VDRE and IZ-CYP24. Vitamin D 13-22 vitamin D receptor Homo sapiens 54-57 27327272-1 2016 Variety of xenobiotics, including therapeutically used vitamin D analogues or environmental and alimentary endocrine disruptors, may interfere with vitamin D receptor (VDR) signaling, with serious physiological or pathophysiological consequences. Vitamin D 55-64 vitamin D receptor Homo sapiens 148-166 27327272-1 2016 Variety of xenobiotics, including therapeutically used vitamin D analogues or environmental and alimentary endocrine disruptors, may interfere with vitamin D receptor (VDR) signaling, with serious physiological or pathophysiological consequences. Vitamin D 55-64 vitamin D receptor Homo sapiens 168-171 27307163-2 2016 Established vitamin D effects are renal and intestinal resorption of calcium and phosphate for optimal bone mineral density; however, the widespread distribution of the vitamin D receptor (VDR), a member of the nuclear steroid hormone receptor family, provides extensive evidence for additional pleiotropic effects of the vitamin D ligand. Vitamin D 12-21 vitamin D receptor Homo sapiens 169-187 27307163-2 2016 Established vitamin D effects are renal and intestinal resorption of calcium and phosphate for optimal bone mineral density; however, the widespread distribution of the vitamin D receptor (VDR), a member of the nuclear steroid hormone receptor family, provides extensive evidence for additional pleiotropic effects of the vitamin D ligand. Vitamin D 12-21 vitamin D receptor Homo sapiens 189-192 27307163-2 2016 Established vitamin D effects are renal and intestinal resorption of calcium and phosphate for optimal bone mineral density; however, the widespread distribution of the vitamin D receptor (VDR), a member of the nuclear steroid hormone receptor family, provides extensive evidence for additional pleiotropic effects of the vitamin D ligand. Vitamin D 169-178 vitamin D receptor Homo sapiens 189-192 26466946-0 2016 The multiple sclerosis-associated regulatory variant rs10877013 affects expression of CYP27B1 and VDR under inflammatory or vitamin D stimuli. Vitamin D 124-133 vitamin D receptor Homo sapiens 98-101 26466946-5 2016 Finally, CYP24A1 was highly induced by the active form of vitamin D and its expression correlated with the expression of VDR in LCLs but neither the MS-associated variant in the region (rs2248359) nor any other variant located in 1 Mb around CYP24A1 was associated with its expression. Vitamin D 58-67 vitamin D receptor Homo sapiens 121-124 27649525-2 2016 The enzyme that produces the active metabolite of vitamin D and ligand for VDR, namely CYP27B1, likewise is widely expressed in many cells of the body. Vitamin D 50-59 vitamin D receptor Homo sapiens 75-78 27239732-15 2016 The anti-inflammatory potential of VDR activation in vitamin D insufficient patients is highly selective and appears to be mediated by an effect on calcineurin-mediated responses. Vitamin D 53-62 vitamin D receptor Homo sapiens 35-38 27196318-1 2016 PURPOSE: Our previous studies show that human corneal epithelial cells (HCEC) have a functional vitamin D receptor (VDR) and respond to vitamin D by dampening TLR-induced inflammation. Vitamin D 96-105 vitamin D receptor Homo sapiens 116-119 27408766-0 2016 Clinical and genetic findings in a Chinese family with VDR-associated hereditary vitamin D-resistant rickets. Vitamin D 81-90 vitamin D receptor Homo sapiens 55-58 27065588-0 2016 Vitamin D Receptor (VDR) Gene Polymorphisms (FokI, BsmI) and their Relation to Vitamin D Status in Pediatrics betaeta Thalassemia Major. Vitamin D 0-9 vitamin D receptor Homo sapiens 20-23 27065588-3 2016 Expression and activation of the vitamin D receptor (VDR) are necessary for the effects of vitamin D, in which several single nucleotide polymorphisms have been identified especially (FokI, BsmI). Vitamin D 33-42 vitamin D receptor Homo sapiens 53-56 27065588-9 2016 In conclusion, these results suggest that the VDR (FokI, BsmI) gene polymorphisms influence vitamin D status, (Ff,ff), BB genotypes had lower vitamin D levels, so they might influence risk of development of bone diseases in beta thalassemia major. Vitamin D 92-101 vitamin D receptor Homo sapiens 46-49 27065588-9 2016 In conclusion, these results suggest that the VDR (FokI, BsmI) gene polymorphisms influence vitamin D status, (Ff,ff), BB genotypes had lower vitamin D levels, so they might influence risk of development of bone diseases in beta thalassemia major. Vitamin D 142-151 vitamin D receptor Homo sapiens 46-49 27160686-1 2016 BACKGROUND: Single nucleotide polymorphisms (SNPs) in the genes encoding the vitamin D receptor (VDR) and the vitamin D binding protein (DBP) have been reported to modify the influence of vitamin D deficiency on susceptibility to active tuberculosis (TB) in the UK, but this phenomenon has not been investigated in settings with a high TB burden. Vitamin D 77-86 vitamin D receptor Homo sapiens 97-100 27127116-1 2016 BACKGROUND: The vitamin D endocrine system is implicated in skin carcinogenesis and polymorphisms in genes associated with the vitamin D receptor (VDR) gene may alter the risk of keratinocyte cancers (basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)). Vitamin D 16-25 vitamin D receptor Homo sapiens 127-145 27127116-1 2016 BACKGROUND: The vitamin D endocrine system is implicated in skin carcinogenesis and polymorphisms in genes associated with the vitamin D receptor (VDR) gene may alter the risk of keratinocyte cancers (basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)). Vitamin D 16-25 vitamin D receptor Homo sapiens 147-150 27309378-1 2016 BACKGROUND: Vitamin D, causally implicated in bone diseases and human malignancies, exerts its effects through binding to the vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 126-144 27309378-1 2016 BACKGROUND: Vitamin D, causally implicated in bone diseases and human malignancies, exerts its effects through binding to the vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 146-149 27203211-1 2016 The relationship between age, vitamin D status, expression and functionality of the vitamin D receptor (VDR), and key genes in the vitamin D pathway in immune cells is unclear. Vitamin D 84-93 vitamin D receptor Homo sapiens 104-107 27139837-6 2016 Among vitamin D pathway gene polymorphisms, VDR FokI T>C was a factor associated with the presence of MC in the study population (P=0.011): related to C allele carriers (TT vs. TC/CC), we obtained a P-value of 0.003. Vitamin D 6-15 vitamin D receptor Homo sapiens 44-47 26715761-1 2016 The physiological functions of vitamin D are mediated by its metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) activating the transcription factor vitamin D receptor (VDR). Vitamin D 31-40 vitamin D receptor Homo sapiens 152-170 26715761-1 2016 The physiological functions of vitamin D are mediated by its metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) activating the transcription factor vitamin D receptor (VDR). Vitamin D 31-40 vitamin D receptor Homo sapiens 172-175 26991835-2 2016 The basis of the interplay between vitamin D and reproduction lays on the presence of both vitamin D receptor (VDR) and 1alpha-hydroxylase (CYP27B1) enzyme in reproductive organs. Vitamin D 35-44 vitamin D receptor Homo sapiens 91-109 26991835-2 2016 The basis of the interplay between vitamin D and reproduction lays on the presence of both vitamin D receptor (VDR) and 1alpha-hydroxylase (CYP27B1) enzyme in reproductive organs. Vitamin D 35-44 vitamin D receptor Homo sapiens 111-114 27245104-1 2016 In many cells throughout the body, vitamin D is converted into its active form calcitriol and binds to the vitamin D receptor (VDR), which functions as a transcription factor to regulate various biological processes including cellular differentiation and immune response. Vitamin D 35-44 vitamin D receptor Homo sapiens 107-125 27245104-1 2016 In many cells throughout the body, vitamin D is converted into its active form calcitriol and binds to the vitamin D receptor (VDR), which functions as a transcription factor to regulate various biological processes including cellular differentiation and immune response. Vitamin D 35-44 vitamin D receptor Homo sapiens 127-130 27245104-2 2016 Vitamin D-metabolising enzymes (including CYP24A1 and CYP27B1) and VDR play major roles in exerting and regulating the effects of vitamin D. Vitamin D 130-139 vitamin D receptor Homo sapiens 67-70 26152509-2 2016 1alpha,25-Dihydroxyvitamin D3 [1,25(OH)2 D3 ], the biologically active metabolite of vitamin D, is a critical modulator of immune response via binding with vitamin D receptor (VDR). Vitamin D 19-28 vitamin D receptor Homo sapiens 156-174 26152509-2 2016 1alpha,25-Dihydroxyvitamin D3 [1,25(OH)2 D3 ], the biologically active metabolite of vitamin D, is a critical modulator of immune response via binding with vitamin D receptor (VDR). Vitamin D 19-28 vitamin D receptor Homo sapiens 176-179 26152509-10 2016 In conclusion, decreased expression of VDR might contribute to the hyperimmune status of AA and appropriate vitamin D supplementation could partly correct the immune dysfunction by strengthening signal transduction through VDR in patients with AA. Vitamin D 108-117 vitamin D receptor Homo sapiens 223-226 27053850-10 2016 Control and IBD patient serum vitamin D levels correlated positively with VDR expression in normal colon from control and IBD patients (r = 0.38, P < 0.05) and with patient age (r = 0.54, P < 0.01). Vitamin D 30-39 vitamin D receptor Homo sapiens 74-77 26907966-3 2016 The vitamin D receptor (VDR) is expressed in epithelial cells of the normal thyroid gland, as well as in malignant dividing cells, which respond to the active metabolite of vitamin D by decreased proliferative activity in vitro. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 26907966-7 2016 There was a high ExR of VDR between Ca/N thyroid tissue from the same patient (3.06+-2.9), which also exhibited a high Ca/N ExR of ECM1 and/or of TMPRSS4 (>2, P=0.05).The finding that increased VDR expression in human thyroid cancer cells is often linked to increased ECM1 and/or TPMRSS4 expression warrants further investigation into the potential role of vitamin D analogs in thyroid carcinoma. Vitamin D 360-369 vitamin D receptor Homo sapiens 24-27 27052925-1 2016 BACKGROUND AND AIMS: 1alpha,25-dihydroxyvitamin-D3, the biologically active vitamin D, plays a central role in several metabolic pathways through the binding to the vitamin D receptor (VDR). Vitamin D 76-85 vitamin D receptor Homo sapiens 165-183 27052925-1 2016 BACKGROUND AND AIMS: 1alpha,25-dihydroxyvitamin-D3, the biologically active vitamin D, plays a central role in several metabolic pathways through the binding to the vitamin D receptor (VDR). Vitamin D 76-85 vitamin D receptor Homo sapiens 185-188 26631034-3 2016 Data from a case-control study of breast cancer (1037 cases and 1050 controls) were used to assess relationships between 21 polymorphisms in two vitamin D-related genes (GC and VDR) and breast cancer risk. Vitamin D 145-154 vitamin D receptor Homo sapiens 177-180 27053850-11 2016 CONCLUSION: Levels of serum vitamin D correlate positively with colonic VDR expression in visually normal mucosa whereas inflammation correlates negatively with colonic VDR expression in visually diseased mucosa in Puerto Rican patients. Vitamin D 28-37 vitamin D receptor Homo sapiens 72-75 27483726-1 2016 Vitamin D (VitD), a lipid-soluble hormone, is able to regulate the transcription of many genes through vitamin D receptor (vitD receptor-VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 103-121 26747961-2 2016 The biological actions of vitamin D are exerted through a soluble protein, the vitamin D receptor (VDR). Vitamin D 26-35 vitamin D receptor Homo sapiens 79-97 26747961-2 2016 The biological actions of vitamin D are exerted through a soluble protein, the vitamin D receptor (VDR). Vitamin D 26-35 vitamin D receptor Homo sapiens 99-102 26747961-3 2016 VDR is a transcription factor located in the nuclei of target cells that mediates the genomic action of the active form of vitamin D (1,25(OH)2D3). Vitamin D 123-132 vitamin D receptor Homo sapiens 0-3 26747961-5 2016 The presence of VDR in female reproductive tissue suggests that vitamin D is involved in female reproduction. Vitamin D 64-73 vitamin D receptor Homo sapiens 16-19 26513524-1 2016 BACKGROUND AND AIM: The vitamin D receptor (VDR) regulates immune responses and inflammation through binding with 1,25-dihydroxyvitamin D, the active form of vitamin D. Vitamin D 24-33 vitamin D receptor Homo sapiens 44-47 26694996-0 2016 Increase of circulating cholesterol in vitamin D deficiency is linked to reduced vitamin D receptor activity via the Insig-2/SREBP-2 pathway. Vitamin D 39-48 vitamin D receptor Homo sapiens 81-99 26694996-6 2016 Under vitamin D deficiency, the transcriptional activity of vitamin D receptor (VDR) was decreased, leading to the downregulation of insulin-induced gene-2 (Insig-2) expression and thus its inhibitory role on sterol regulatory element-binding protein 2 activation; 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression was accordingly increased. Vitamin D 6-15 vitamin D receptor Homo sapiens 60-78 26694996-6 2016 Under vitamin D deficiency, the transcriptional activity of vitamin D receptor (VDR) was decreased, leading to the downregulation of insulin-induced gene-2 (Insig-2) expression and thus its inhibitory role on sterol regulatory element-binding protein 2 activation; 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression was accordingly increased. Vitamin D 6-15 vitamin D receptor Homo sapiens 80-83 26694996-7 2016 Vitamin D3 was protective against vitamin D deficiency-induced cholesterol increase by maintaining the transcriptional activity of VDR and Insig-2 expression. Vitamin D 34-43 vitamin D receptor Homo sapiens 131-134 26694996-8 2016 CONCLUSION: Vitamin D deficiency is associated with the increase of circulating cholesterol in the people of northern China by enhancing hepatic cholesterol biosynthesis, which was linked to the reduction of transcriptional activity of VDR. Vitamin D 12-21 vitamin D receptor Homo sapiens 236-239 27064335-5 2016 It is assumed that vitamin D deficiency and genetic predisposition, for example, polymorphisms of vitamin D receptor, have a great significance. Vitamin D 19-28 vitamin D receptor Homo sapiens 98-116 27483726-1 2016 Vitamin D (VitD), a lipid-soluble hormone, is able to regulate the transcription of many genes through vitamin D receptor (vitD receptor-VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 137-140 27186331-3 2016 Vitamin-D action is mediated by the vitamin-D receptor. Vitamin D 0-9 vitamin D receptor Homo sapiens 36-54 27114922-1 2016 INTRODUCTION: We studied the frequencies of the 3" and 5"-end vitamin D receptor (VDR) gene polymorphisms and their correlation with bone mineral density (BMD) in Egyptian pediatric acute lymphoblastic leukemia (ALL) patients receiving calcium and vitamin D supplements. Vitamin D 62-71 vitamin D receptor Homo sapiens 82-85 27114922-2 2016 The purpose of this study is to find out the relation between VDR polymorphism and the response to vitamin D intake in pediatric ALL cases who receive corticosteroid therapy which predispose to osteoporosis. Vitamin D 99-108 vitamin D receptor Homo sapiens 62-65 25738688-13 2016 The VDR genotype might become more relevant when clustered in a specific haplotype, associated with other SNPs of genes involved in vitamin D metabolism, or for specific tumors and/or patient characteristics. Vitamin D 132-141 vitamin D receptor Homo sapiens 4-7 26423691-9 2016 In addition, the finding that the VDR polymorphism TaqI was associated with myopathy may indicate a causal relationship between vitamin D function and myopathy, but larger studies are needed before firm conclusions can be drawn. Vitamin D 128-137 vitamin D receptor Homo sapiens 34-37 26774929-8 2016 For the first time, we showed that calcitroic acid, the assumed inactive final metabolite of vitamin D, was able to activate VDR-mediated transcription to a higher magnitude than bile acid LCA. Vitamin D 93-102 vitamin D receptor Homo sapiens 125-128 28808527-4 2016 The present ligand is the first secosteroidal analog with the carborane unit that efficiently binds to VDR and functions as an agonist with 1,25D-like potency in transcriptional assay on vitamin D target genes. Vitamin D 187-196 vitamin D receptor Homo sapiens 103-106 26446365-1 2016 Vitamin D has been considered as an immune modulator, and exerted the effect through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 89-107 26446365-1 2016 Vitamin D has been considered as an immune modulator, and exerted the effect through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 109-112 26479950-1 2016 The discovery of vitamin D receptor (VDR) expression in immune cells has opened up a new area of research into immunoregulation by vitamin D, a niche that is distinct from its classical role in skeletal health. Vitamin D 17-26 vitamin D receptor Homo sapiens 37-40 26911666-8 2016 CONCLUSION: Vitamin D related (VDR rs2228570 and CYP2R1 rs10741657) and IL28B rs12979860 genes polymorphisms accurately assure SVR in naive CHC G4 patients treated with low cost standard therapy. Vitamin D 12-21 vitamin D receptor Homo sapiens 31-34 26304030-3 2016 CAMP gene expression is regulated by vitamin D-dependent (VDR) and vitamin D-independent (C/EBPalpha) transcription factors. Vitamin D 37-46 vitamin D receptor Homo sapiens 58-61 25727561-1 2016 Vitamin D is a steroid hormone, which in active form binds to the vitamin D receptor. Vitamin D 0-9 vitamin D receptor Homo sapiens 66-84 26678915-5 2016 Both vitamin D receptor (VDR) and 25-hydroxyvitamin D3 1-alpha-hydroxylase (CYP27B1) are expressed in several types of immune cells (i.e. antigen presenting cells, T and B cells), and thus, they are able to synthetize the bioactive form of vitamin D that modulates both the innate and adaptive immune system. Vitamin D 5-14 vitamin D receptor Homo sapiens 25-28 27195054-9 2016 In conclusion, the inflammatory cytokine TNF increases the response of keratinocytes to calcitriol through upregulation of its receptor VDR, which in turn is subject to negative feedback by the hormone accelerating the return of the keratinocyte vitamin D system to its basal activity. Vitamin D 246-255 vitamin D receptor Homo sapiens 136-139 26654942-9 2016 Studies employing VDR siRNA, CYP27B1 zinc finger nucleases, and pharmacologic inhibitors of the vitamin D pathway indicate that 25D3 regulates gene expression in a VDR-dependent manner but does not strictly require 1alphaOHase-mediated conversion of 25D3 to 1,25D3. Vitamin D 96-105 vitamin D receptor Homo sapiens 164-167 26646255-9 2016 Vitamin-D and estradiol 17-beta upregulated VDR expression. Vitamin D 0-9 vitamin D receptor Homo sapiens 44-47 26646255-12 2016 Female sex steroids and vitamin-D promoted tendon-derived cell proliferation via estrogen receptor alpha and VDR, not estrogen receptor beta. Vitamin D 24-33 vitamin D receptor Homo sapiens 109-112 26827954-2 2016 This activity is commonly attributed to direct binding of 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3, calcitriol], the hormonally active form of vitamin D, to the vitamin D receptor (VDR). Vitamin D 77-86 vitamin D receptor Homo sapiens 168-186 26853300-2 2016 Immune cells express the vitamin D receptor, including antigen presenting cells, T cells and B cells, and these cells are all capable of synthesizing the biologically active vitamin D metabolite, 1, 25 hydroxy vitamin D.There has been growing interest in the benefits of supplementing vitamin D as studies report vitamin D insufficiency (circulating 25(OH)D < 50 nmol/L) in more than half of all athletes and military personnel tested during the winter, when skin sunlight UVB is negligible. Vitamin D 174-183 vitamin D receptor Homo sapiens 25-43 26853300-2 2016 Immune cells express the vitamin D receptor, including antigen presenting cells, T cells and B cells, and these cells are all capable of synthesizing the biologically active vitamin D metabolite, 1, 25 hydroxy vitamin D.There has been growing interest in the benefits of supplementing vitamin D as studies report vitamin D insufficiency (circulating 25(OH)D < 50 nmol/L) in more than half of all athletes and military personnel tested during the winter, when skin sunlight UVB is negligible. Vitamin D 174-183 vitamin D receptor Homo sapiens 25-43 26943610-5 2016 VDR is often co-localized with its metabolizing enzymes, suggesting the importance of tissue specific modulation of active vitamin D levels. Vitamin D 123-132 vitamin D receptor Homo sapiens 0-3 26058412-8 2016 However, vitamin D could reverse the inhibition of both VDR and LL-37 [1.5-fold increase (P = 0.001) and 2000-fold increase (P < 0.001) respectively]. Vitamin D 9-18 vitamin D receptor Homo sapiens 56-59 26058412-10 2016 CONCLUSIONS: When vitamin D levels were low, bacteria inhibited VDR and LL-37 responses in peritoneal macrophages as a mechanism to evade antibacterial defence. Vitamin D 18-27 vitamin D receptor Homo sapiens 64-67 26058412-11 2016 Vitamin D supplementation could up-regulate peritoneal macrophage VDR and LL-37 expressions, which resulted in an enhanced immunological defence against SBP in patients with cirrhosis and ascites. Vitamin D 0-9 vitamin D receptor Homo sapiens 66-69 26681795-6 2016 Although the identification of mechanisms mediating VDR-regulated transcription has been one focus of recent research in the field, other topics of fundamental importance include the identification and functional significance of proteins involved in the metabolism of vitamin D. Vitamin D 268-277 vitamin D receptor Homo sapiens 52-55 26366751-4 2016 Vitamin D receptor activation using a vitamin D responsive element-mediated cytochrome P450 3A4 reporter gene assay was investigated in Caco-2 cells transfected with human vitamin D receptor. Vitamin D 38-47 vitamin D receptor Homo sapiens 0-18 26827947-3 2016 Current studies are now refocused on the vitamin D hormone"s action at the genome, where VDR together with other transcription factors coordinates the recruitment of chromatin active coregulatory complexes that participate directly in the modification of gene output. Vitamin D 41-50 vitamin D receptor Homo sapiens 89-92 26827947-8 2016 These studies advance our understanding of not only vitamin D action but also of the complex and dynamic role played by the genome itself as a major determinant of VDR activity. Vitamin D 52-61 vitamin D receptor Homo sapiens 164-167 26827949-8 2016 Additionally, we describe the crystal structures of VDR mutants associated with hereditary vitamin D-resistant rickets that display impaired ligand-binding function. Vitamin D 91-100 vitamin D receptor Homo sapiens 52-55 26827953-1 2016 1,25-Dihydroxyvitamin D3 (1,25D) is the renal metabolite of vitamin D that signals through binding to the nuclear vitamin D receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 114-132 26827953-1 2016 1,25-Dihydroxyvitamin D3 (1,25D) is the renal metabolite of vitamin D that signals through binding to the nuclear vitamin D receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 134-137 27958635-1 2016 OBJECTIVES: Vitamin D receptor (VDR) is expressed in the placenta and tissues related to the immune system occurrence of various variants of VDR may modify the effects of vitamin D on pregnancy. Vitamin D 171-180 vitamin D receptor Homo sapiens 12-30 27958635-1 2016 OBJECTIVES: Vitamin D receptor (VDR) is expressed in the placenta and tissues related to the immune system occurrence of various variants of VDR may modify the effects of vitamin D on pregnancy. Vitamin D 171-180 vitamin D receptor Homo sapiens 32-35 27958635-1 2016 OBJECTIVES: Vitamin D receptor (VDR) is expressed in the placenta and tissues related to the immune system occurrence of various variants of VDR may modify the effects of vitamin D on pregnancy. Vitamin D 171-180 vitamin D receptor Homo sapiens 141-144 26686848-3 2016 Recent studies have demonstrated that vitamin D, through its receptor (VDR), is able to regulate the immune balance and suppress the autoimmunity process, being a potential target in autoimmune diseases. Vitamin D 38-47 vitamin D receptor Homo sapiens 71-74 26904920-1 2016 Vitamin D receptor (VDR) gene polymorphisms may influence risk for adenomatous polyps (AP), a benign precursor to colon cancer, via modulation of vitamin D sensitive pathways, including cell proliferation and differentiation. Vitamin D 146-155 vitamin D receptor Homo sapiens 0-18 26904920-1 2016 Vitamin D receptor (VDR) gene polymorphisms may influence risk for adenomatous polyps (AP), a benign precursor to colon cancer, via modulation of vitamin D sensitive pathways, including cell proliferation and differentiation. Vitamin D 146-155 vitamin D receptor Homo sapiens 20-23 26827954-2 2016 This activity is commonly attributed to direct binding of 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3, calcitriol], the hormonally active form of vitamin D, to the vitamin D receptor (VDR). Vitamin D 77-86 vitamin D receptor Homo sapiens 188-191 26827954-3 2016 More recently, calcitriol and VDR have been shown to control the expression of genes associated with cellular proliferation and differentiation in a wide variety of cells, suggesting more extensive biological activities for the vitamin D system. Vitamin D 228-237 vitamin D receptor Homo sapiens 30-33 26827958-5 2016 Biological effects of vitamin D are mediated by altered expression of a gene network regulated by the vitamin D receptor (VDR), which is a multidomain, ligand-inducible transcription factor similar to AR and other nuclear receptors. Vitamin D 22-31 vitamin D receptor Homo sapiens 102-120 26827958-5 2016 Biological effects of vitamin D are mediated by altered expression of a gene network regulated by the vitamin D receptor (VDR), which is a multidomain, ligand-inducible transcription factor similar to AR and other nuclear receptors. Vitamin D 22-31 vitamin D receptor Homo sapiens 122-125 26441239-9 2015 Introduction of transgenes for either mouse or human VDR also normalized vitamin D metabolism in VDR null mice, whereas this metabolic pattern was unaffected by a transgene encoding a ligand binding-deficient mutant (L233S) human VDR. Vitamin D 73-82 vitamin D receptor Homo sapiens 53-56 26644513-5 2015 Using pharmacological and knockdown approaches we show that RXR-VDR signaling induces OPC differentiation and that VDR agonist vitamin D enhances OPC differentiation. Vitamin D 127-136 vitamin D receptor Homo sapiens 115-118 27141540-1 2015 BACKGROUND: Vitamin D and insulin play an important role in susceptibility to polycystic ovary syndrome (PCOS), and therefore vitamin D receptor (VDR), parathyroid hormone (PTH), and insulin receptor (INSR) gene variants might be involved in the pathogenesis of PCOS. Vitamin D 12-21 vitamin D receptor Homo sapiens 126-144 26476188-4 2015 Analysis of 24 vitamin D analogs, bearing similar molecular structures complexed with Vitamin D Receptor enabled the design of new agonists forming all advantageous interaction to the receptor, coded TB1, TB2, TB3 and TB4. Vitamin D 15-24 vitamin D receptor Homo sapiens 86-104 26641549-8 2015 RESULTS: When treated with inactive vitamin D metabolites, HCEC produced active 1,25D3, leading to enhanced expression of the antimicrobial peptide, LL-37, dependent on VDR. Vitamin D 36-45 vitamin D receptor Homo sapiens 169-172 26346470-0 2015 Vitamin D receptor Cdx-2-dependent response of central obesity to vitamin D intake in the subjects with type 2 diabetes: a randomised clinical trial. Vitamin D 66-75 vitamin D receptor Homo sapiens 0-18 26346470-1 2015 This study aimed to investigate the effects of daily intake of vitamin D-fortified yogurt drink (doogh) on central obesity indicators in subjects with type 2 diabetes (T2D) and the possible modulation of this effect by vitamin D receptor (VDR) Cdx-2 genotypes. Vitamin D 63-72 vitamin D receptor Homo sapiens 219-237 26346470-1 2015 This study aimed to investigate the effects of daily intake of vitamin D-fortified yogurt drink (doogh) on central obesity indicators in subjects with type 2 diabetes (T2D) and the possible modulation of this effect by vitamin D receptor (VDR) Cdx-2 genotypes. Vitamin D 63-72 vitamin D receptor Homo sapiens 239-242 26346470-7 2015 Daily intake of vitamin D-FD for 12 weeks improved the central obesity indices in T2D subjects, and the improvement was more pronounced in the carriers of the AA genotype of VDR-Cdx-2. Vitamin D 16-25 vitamin D receptor Homo sapiens 174-177 26501255-12 2015 We also suggest that vitamin D-based therapies may represent an adjuvant strategy in treatment for bladder cancers expressing VDR. Vitamin D 21-30 vitamin D receptor Homo sapiens 126-129 26517870-1 2015 BACKGROUND: Vitamin D is postulated to decrease the risk of breast cancer by inhibiting cell proliferation via the vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 115-133 26517870-1 2015 BACKGROUND: Vitamin D is postulated to decrease the risk of breast cancer by inhibiting cell proliferation via the vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 135-138 26355700-1 2015 Active forms of vitamin D regulate the expression of multiple genes that play essential roles in calcium and phosphate homeostasis, cell differentiation, and the immune system via the vitamin D receptor (VDR). Vitamin D 16-25 vitamin D receptor Homo sapiens 184-202 26355700-1 2015 Active forms of vitamin D regulate the expression of multiple genes that play essential roles in calcium and phosphate homeostasis, cell differentiation, and the immune system via the vitamin D receptor (VDR). Vitamin D 16-25 vitamin D receptor Homo sapiens 204-207 26355700-7 2015 Our results on chimeric luciferases containing the LBDs of mutant VDRs derived from patients with vitamin D-dependent type II rickets indicated that our system could detect a conformational change of the LBD of the VDR likely based on a positional change of the helix 12, which occurs upon ligand binding. Vitamin D 98-107 vitamin D receptor Homo sapiens 66-69 26540116-6 2015 VDR variant FokI associated with higher vitamin D levels in both groups. Vitamin D 40-49 vitamin D receptor Homo sapiens 0-3 26677265-3 2015 Vitamin D has stimulatory effects on melanocytes and acts through its nuclear Vitamin D receptor (VDR) on target cells. Vitamin D 0-9 vitamin D receptor Homo sapiens 78-96 26677265-3 2015 Vitamin D has stimulatory effects on melanocytes and acts through its nuclear Vitamin D receptor (VDR) on target cells. Vitamin D 0-9 vitamin D receptor Homo sapiens 98-101 26422470-1 2015 Hereditary 1, 25-dihydroxyvitamin D-resistant rickets (HVDRR), a rare recessive disease, is caused by mutation in the VDR gene encoding the vitamin D receptor leading to the resistance to vitamin D. Vitamin D 26-35 vitamin D receptor Homo sapiens 140-158 26224799-2 2015 Variants in the vitamin D receptor (VDR) gene have the potential to modify associations between vitamin D intake and colorectal cancer. Vitamin D 16-25 vitamin D receptor Homo sapiens 36-39 26010336-1 2015 Even in cells that are resistant to the differentiating effects of vitamin D, the activated vitamin D receptor (VDR) can downregulate the mitochondrial respiratory chain and sustain cell growth through enhancing the activity of biosynthetic pathways. Vitamin D 67-76 vitamin D receptor Homo sapiens 92-110 26010336-1 2015 Even in cells that are resistant to the differentiating effects of vitamin D, the activated vitamin D receptor (VDR) can downregulate the mitochondrial respiratory chain and sustain cell growth through enhancing the activity of biosynthetic pathways. Vitamin D 67-76 vitamin D receptor Homo sapiens 112-115 26722516-0 2015 Alterations in vitamin D signaling pathway in gastric cancer progression: a study of vitamin D receptor expression in human normal, premalignant, and malignant gastric tissue. Vitamin D 15-24 vitamin D receptor Homo sapiens 85-103 25878189-5 2015 The VDR gene is additionally examined as a factor in the evolutionary selection of skin depigmentation at higher latitudes to allow vitamin D synthesis. Vitamin D 132-141 vitamin D receptor Homo sapiens 4-7 26448018-1 2015 To investigate whether single nucleotide polymorphisms (SNPs) within 4 representative genes (VDR, GC, CYP2R1, and CYP24A1) encoding the core proteins involved in vitamin D production, degradation, and ligand-dependent signaling pathway are associated with gestational diabetes mellitus (GDM) in a Chinese population. Vitamin D 162-171 vitamin D receptor Homo sapiens 93-96 26904855-3 2015 Vitamin D metabolic enzymes synthesize and degrade active vitamin D3 and its metabolic intermediates, and active vitamin D3 exerts its biological effects through binding to vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 173-191 26904855-3 2015 Vitamin D metabolic enzymes synthesize and degrade active vitamin D3 and its metabolic intermediates, and active vitamin D3 exerts its biological effects through binding to vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 193-196 26422470-1 2015 Hereditary 1, 25-dihydroxyvitamin D-resistant rickets (HVDRR), a rare recessive disease, is caused by mutation in the VDR gene encoding the vitamin D receptor leading to the resistance to vitamin D. Vitamin D 26-35 vitamin D receptor Homo sapiens 56-59 26504744-3 2015 Recent studies connected the gene encoding for vitamin D (VDR) to the genetic control of bone mass and other diseases. Vitamin D 47-56 vitamin D receptor Homo sapiens 58-61 26210580-2 2015 Its genomic actions are mediated via the active form of vitamin D, 1,25(OH)2D3, binding to the vitamin D receptor (VDR). Vitamin D 56-65 vitamin D receptor Homo sapiens 95-113 26210580-2 2015 Its genomic actions are mediated via the active form of vitamin D, 1,25(OH)2D3, binding to the vitamin D receptor (VDR). Vitamin D 56-65 vitamin D receptor Homo sapiens 115-118 26184408-2 2015 By binding the active vitamin D hormone to the vitamin D receptor (VDR), it acts as a nuclear transcription factor (Bouillon et al., Endocr Rev 29(6):726-776, 2008). Vitamin D 22-31 vitamin D receptor Homo sapiens 47-65 26184408-2 2015 By binding the active vitamin D hormone to the vitamin D receptor (VDR), it acts as a nuclear transcription factor (Bouillon et al., Endocr Rev 29(6):726-776, 2008). Vitamin D 22-31 vitamin D receptor Homo sapiens 67-70 26346690-1 2015 BACKGROUND: Polymorphisms in the vitamin D receptor (VDR) gene have been studied in immune-related disorders either as independent contributors or in combination with vitamin D concentration. Vitamin D 33-42 vitamin D receptor Homo sapiens 53-56 25931412-5 2015 Active vitamin D analogs, capable of binding the vitamin D receptor evoking vitamin D-related biological effects, are mandatorily employed in hypoparathyroidism and kidney failure with impaired 1alpha-hydroxylation. Vitamin D 7-16 vitamin D receptor Homo sapiens 49-67 25641222-8 2015 Vitamin D analogues may provide a therapeutic choice for patients with high VDR expression in tumours but a low vitamin D level in the circulation. Vitamin D 0-9 vitamin D receptor Homo sapiens 76-79 26458343-1 2015 BACKGROUND & OBJECTIVES: The Vitamin-D receptor (VDR) regulates vitamin D levels and calcium metabolism in the body and these are known to be associated with endocrine dysfunctions, insulin resistance and type-2 diabetes in polycystic ovarian syndrome (PCOS). Vitamin D 68-77 vitamin D receptor Homo sapiens 33-51 26458343-1 2015 BACKGROUND & OBJECTIVES: The Vitamin-D receptor (VDR) regulates vitamin D levels and calcium metabolism in the body and these are known to be associated with endocrine dysfunctions, insulin resistance and type-2 diabetes in polycystic ovarian syndrome (PCOS). Vitamin D 68-77 vitamin D receptor Homo sapiens 53-56 26184408-3 2015 The discovery that almost all tissues and cells in the body express the VDR and that several tissues possess the enzymatic capability to convert 25-hydroxyvitamin D (25(OH)-D3; cholecalciferol) to the active form, suggests that vitamin D fulfills various extra-osseous functions (Bouillon et al., Endocr Rev 29(6):726-776, 2008; Holick, N Engl J Med 357(3):266-281, 2007). Vitamin D 155-164 vitamin D receptor Homo sapiens 72-75 25804799-2 2015 The mechanism of vitamin D action is mediated by the vitamin D receptor (VDR). Vitamin D 17-26 vitamin D receptor Homo sapiens 53-71 26347716-3 2015 On that account, active vitamin D, the ligand of VDR, is used as an adjuvant therapy to control infection, slow down progression of chronic kidney diseases, and cancer chemotherapy. Vitamin D 24-33 vitamin D receptor Homo sapiens 49-52 26025591-8 2015 The presence of vitamin D receptor (VDR) and the enzyme responsible for conversion of the 25(OH)D in its active metabolite 25(OH)2D3 in extra renal tissue shows the involvement of vitamin D in other diseases like cancer, diabetes, multiple sclerosis etc. Vitamin D 16-25 vitamin D receptor Homo sapiens 36-39 25517289-1 2015 OBJECTIVE: To examine the vitamin D status, SNP of the vitamin D receptor gene (VDR) and the effects of vitamin D supplementation on parathyroid hormone and insulin secretion in adult males with obesity or normal weight in a subtropical Chinese city. Vitamin D 55-64 vitamin D receptor Homo sapiens 80-83 26288665-4 2015 Sophisticated experimental techniques have allowed detection of the vitamin D receptor (VDR) on skeletal muscle and cerebellar tissue, which if validated in further large studies, could confirm the mechanism of vitamin D in these associations. Vitamin D 68-77 vitamin D receptor Homo sapiens 88-91 25804799-2 2015 The mechanism of vitamin D action is mediated by the vitamin D receptor (VDR). Vitamin D 17-26 vitamin D receptor Homo sapiens 73-76 25707738-4 2015 The aim of this study was to establish a flow cytometry protocol, including nuclear and cytoplasmic VDR expression, and to investigate the effects of vitamin D treatment on T cell VDR expression in CD patients. Vitamin D 150-159 vitamin D receptor Homo sapiens 180-183 25837735-6 2015 From this holistic viewpoint, we offer new insights into an old debate: whether vitamin D"s effects in the musculoskeletal system are direct via local VDR signals or indirect via its systemic effects in calcium and phosphate homeostasis. Vitamin D 80-89 vitamin D receptor Homo sapiens 151-154 26217190-10 2015 The immuno-modulatory properties of vitamin D receptor (VDR) suggest that vitamin D is an attractive and plausible candidate in spite of controversial findings. Vitamin D 36-45 vitamin D receptor Homo sapiens 56-59 26180726-9 2015 The physiologically active form of vitamin D, 1,25(OH)2D3, inhibits the proliferation of keloid fibroblasts, and correlations between vitamin D receptor polymorphisms, such as the TaqI CC genotype, and keloid formation have been reported. Vitamin D 35-44 vitamin D receptor Homo sapiens 134-152 25707738-2 2015 Vitamin D has immune modulatory effects on T cells through the nuclear vitamin D receptor (VDR) in vitro. Vitamin D 0-9 vitamin D receptor Homo sapiens 71-89 25707738-12 2015 This VDR up-regulation was inhibited with 30% by vitamin D treatment compared to placebo in CD patients (P = 0027). Vitamin D 49-58 vitamin D receptor Homo sapiens 5-8 25707738-2 2015 Vitamin D has immune modulatory effects on T cells through the nuclear vitamin D receptor (VDR) in vitro. Vitamin D 0-9 vitamin D receptor Homo sapiens 91-94 25707738-15 2015 Vitamin D treatment in CD patients reduces T cell receptor-mediated VDR up-regulation. Vitamin D 0-9 vitamin D receptor Homo sapiens 68-71 26119311-4 2015 The VDR functions in a largely 1alpha,25 (OH) (2)D(3)-controlled manner by interacting directly with vitamin D response elements located within regulatory regions that are linked to cell-specific target genes. Vitamin D 101-110 vitamin D receptor Homo sapiens 4-7 26252259-2 2015 Vitamin D functions are not limited to the regulation of bone; it plays many pleiotropic effects due to ubiquitous distribution of VDR (Vitamin D Receptor). Vitamin D 0-9 vitamin D receptor Homo sapiens 131-134 26252259-2 2015 Vitamin D functions are not limited to the regulation of bone; it plays many pleiotropic effects due to ubiquitous distribution of VDR (Vitamin D Receptor). Vitamin D 0-9 vitamin D receptor Homo sapiens 136-154 26403394-5 2015 Vitamin D binds its receptor VDR, resulting in transcription of a number of genes playing a role in inhibition of MAPK. Vitamin D 0-9 vitamin D receptor Homo sapiens 29-32 25716068-3 2015 The placenta as an important source of vitamin D regulates its metabolism through the vitamin D receptor (VDR), but the mechanism by which VDR regulates trophoblast function is poorly understood. Vitamin D 39-48 vitamin D receptor Homo sapiens 86-104 25716068-3 2015 The placenta as an important source of vitamin D regulates its metabolism through the vitamin D receptor (VDR), but the mechanism by which VDR regulates trophoblast function is poorly understood. Vitamin D 39-48 vitamin D receptor Homo sapiens 106-109 25510525-1 2015 Vitamin D is associated with skeletal muscle physiology and function and may play a role in intramuscular inflammation, possibly via the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 137-155 25661837-2 2015 One such environmental factor is vitamin D, a vital hormone that plays a specific function in the immune system homeostasis, acting through a nuclear receptor (VDR) expressed in all immune cells. Vitamin D 33-42 vitamin D receptor Homo sapiens 160-163 26105695-1 2015 Vitamin D is a potential protective agent against cancer, and its activity is mediated mainly by vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 97-115 26105695-1 2015 Vitamin D is a potential protective agent against cancer, and its activity is mediated mainly by vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 117-120 25510525-1 2015 Vitamin D is associated with skeletal muscle physiology and function and may play a role in intramuscular inflammation, possibly via the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 157-160 25536521-1 2015 The 1,25-dihydroxyvitamin D3 (1,25D) hormone is derived from vitamin D generated in skin or obtained from the diet, and binds to and activates the vitamin D receptor (VDR) in target tissues including kidney, colon/small intestine, and bone/muscle. Vitamin D 18-27 vitamin D receptor Homo sapiens 147-165 25536521-1 2015 The 1,25-dihydroxyvitamin D3 (1,25D) hormone is derived from vitamin D generated in skin or obtained from the diet, and binds to and activates the vitamin D receptor (VDR) in target tissues including kidney, colon/small intestine, and bone/muscle. Vitamin D 18-27 vitamin D receptor Homo sapiens 167-170 25536521-10 2015 The results of this study elucidate a possible pathway for crosstalk between two nutritionally derived lipids, vitamin D and resveratrol, both of which converge on VDR signaling. Vitamin D 111-120 vitamin D receptor Homo sapiens 164-167 25809484-2 2015 This study reports modulation of Smad signaling by the specific binding of the VDR along with its heterodimeric partner RXR to the negative vitamin D response element on the promoter of Smad7, which leads to Smad7 gene repression. Vitamin D 140-149 vitamin D receptor Homo sapiens 79-82 26155287-1 2015 PURPOSE: According to previous studies, vitamin D exhibits protective effects against breast cancer via the vitamin D receptor (VDR). Vitamin D 40-49 vitamin D receptor Homo sapiens 108-126 26155287-1 2015 PURPOSE: According to previous studies, vitamin D exhibits protective effects against breast cancer via the vitamin D receptor (VDR). Vitamin D 40-49 vitamin D receptor Homo sapiens 128-131 25708797-1 2015 UNLABELLED: Adding to the debate around vitamin D"s effects on skeletal health, we report the long-term follow-up of two patients with severe vitamin D receptor mutations, who had normal bone mass acquisition and normalization of calcemia around puberty, suggesting that vitamin D might not be essential for skeletal health in adulthood. Vitamin D 40-49 vitamin D receptor Homo sapiens 142-160 25708797-3 2015 Individuals bearing homozygous vitamin D receptor (VDR) defects present with severe hypocalcemic rickets in early infancy due to vitamin D resistance. Vitamin D 31-40 vitamin D receptor Homo sapiens 51-54 25708797-13 2015 The normalization of calcemia and normal bone mass acquisition despite a permanently dysfunctional VDR suggest that vitamin D might not be essential for skeletal health in adulthood. Vitamin D 116-125 vitamin D receptor Homo sapiens 99-102 25377645-2 2015 As the specific receptor of vitamin D, VDR plays an important role in regulating immune system by combining with vitamin D. Vitamin D 28-37 vitamin D receptor Homo sapiens 39-42 25377645-2 2015 As the specific receptor of vitamin D, VDR plays an important role in regulating immune system by combining with vitamin D. Vitamin D 113-122 vitamin D receptor Homo sapiens 39-42 26106480-1 2015 We studied the roles of vitamin D and its receptor, VDR, in the progression of leprosy. Vitamin D 24-33 vitamin D receptor Homo sapiens 52-55 25873367-1 2015 One variable that may affect the ability of vitamin D to reduce colon cancer risk is the expression of its high-affinity receptor, VDR. Vitamin D 44-53 vitamin D receptor Homo sapiens 131-134 25873367-11 2015 Determining the mechanisms of VDR regulation in colon neoplasms may significantly enhance our ability to use vitamin D as a cancer prevention agent. Vitamin D 109-118 vitamin D receptor Homo sapiens 30-33 25910066-15 2015 This VDR haplotype could be useful in identifying individuals who benefit most from vitamin D chemoprevention. Vitamin D 84-93 vitamin D receptor Homo sapiens 5-8 25447737-1 2015 The active form of vitamin D (1alpha,25-dihydroxyvitamin D, 1,25(OH)2D) exerts its genomic effects via binding to a nuclear high-affinity vitamin D receptor (VDR). Vitamin D 19-28 vitamin D receptor Homo sapiens 138-156 25881523-2 2015 In recent years, the discovery of vitamin D-metabolizing enzymes and vitamin D receptor (VDR) in the lungs and various cells of the immune system has led to numerous studies conducted to evaluate its role in respiratory functions and, in particular, upper respiratory tract infections (URTIs). Vitamin D 34-43 vitamin D receptor Homo sapiens 89-92 25849303-1 2015 Vitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 66-84 25849303-1 2015 Vitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 86-89 25849303-3 2015 VDR is a critical component of the vitamin D pathway and different common single nucleotide polymorphisms have been identified. Vitamin D 35-44 vitamin D receptor Homo sapiens 0-3 25849303-8 2015 Vitamin D treatment efficacy was found to be strongly dependent on the Cdx2 VDR status in ER-negative breast cancer cell lines tested. Vitamin D 0-9 vitamin D receptor Homo sapiens 76-79 25849303-10 2015 Our results may suggest a potential effect of Cdx2 VDR polymorphism on the efficacy of vitamin D treatment in aggressive breast cancer cells (estrogen receptor negative). Vitamin D 87-96 vitamin D receptor Homo sapiens 51-54 25448744-12 2015 Of importance in the observation is that several regulatory effects are deranged in the presence of hyperglycemia, particularly the PTH- and vitamin D-dependent up regulation of VDR and 1OHase in these cells. Vitamin D 141-150 vitamin D receptor Homo sapiens 178-181 25447737-1 2015 The active form of vitamin D (1alpha,25-dihydroxyvitamin D, 1,25(OH)2D) exerts its genomic effects via binding to a nuclear high-affinity vitamin D receptor (VDR). Vitamin D 19-28 vitamin D receptor Homo sapiens 158-161 25576905-0 2015 VDR FokI polymorphism is associated with a reduced T-helper cell population under vitamin D stimulation in type 1 diabetes patients. Vitamin D 82-91 vitamin D receptor Homo sapiens 0-3 25447737-2 2015 Recent deep sequencing analysis of VDR binding locations across the complete genome has significantly expanded our understanding of the actions of vitamin D and VDR on gene transcription. Vitamin D 147-156 vitamin D receptor Homo sapiens 35-38 25576905-2 2015 Additionally, the immune system regulator vitamin D, exerts its modulatory effects through the vitamin D receptor (VDR) expressed in Th cells. Vitamin D 42-51 vitamin D receptor Homo sapiens 95-113 25576905-2 2015 Additionally, the immune system regulator vitamin D, exerts its modulatory effects through the vitamin D receptor (VDR) expressed in Th cells. Vitamin D 42-51 vitamin D receptor Homo sapiens 115-118 25447737-9 2015 hnRNPC, has been shown to be involved in the VDR transcriptional complex as a vitamin D-response element-binding protein (VDRE-BP), and may act as a coupling factor linking VDR-directed gene transcription with RNA splicing. Vitamin D 78-87 vitamin D receptor Homo sapiens 45-48 25447737-9 2015 hnRNPC, has been shown to be involved in the VDR transcriptional complex as a vitamin D-response element-binding protein (VDRE-BP), and may act as a coupling factor linking VDR-directed gene transcription with RNA splicing. Vitamin D 78-87 vitamin D receptor Homo sapiens 122-125 25603468-7 2015 Consistently, colonic epithelial VDR levels are markedly reduced in patients with inflammatory bowel diseases or in experimental colitis models, whereas vitamin D analog therapy that ameliorates colitis up-regulates epithelial VDR. Vitamin D 153-162 vitamin D receptor Homo sapiens 227-230 25376135-3 2015 Since vitamin D acts through the vitamin D receptor (VDR), association of single nucleotide polymorphisms (SNPs) in the VDR gene might account for variations in the MS risk within populations. Vitamin D 6-15 vitamin D receptor Homo sapiens 33-51 25376135-3 2015 Since vitamin D acts through the vitamin D receptor (VDR), association of single nucleotide polymorphisms (SNPs) in the VDR gene might account for variations in the MS risk within populations. Vitamin D 6-15 vitamin D receptor Homo sapiens 53-56 25376135-3 2015 Since vitamin D acts through the vitamin D receptor (VDR), association of single nucleotide polymorphisms (SNPs) in the VDR gene might account for variations in the MS risk within populations. Vitamin D 6-15 vitamin D receptor Homo sapiens 120-123 25799011-3 2015 We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma. Vitamin D 15-24 vitamin D receptor Homo sapiens 59-62 25595352-0 2015 Association between vitamin D concentration and levels of sex hormones in an elderly Polish population with different genotypes of VDR polymorphisms (rs10735810, rs1544410, rs7975232, rs731236). Vitamin D 20-29 vitamin D receptor Homo sapiens 131-134 25595352-2 2015 The aim of this study was to determine whether there is an association of vitamin D concentration vs the level of sex hormones in elderly Polish individuals with different genotypes of the vitamin D receptor (VDR) gene. Vitamin D 74-83 vitamin D receptor Homo sapiens 189-207 25595352-2 2015 The aim of this study was to determine whether there is an association of vitamin D concentration vs the level of sex hormones in elderly Polish individuals with different genotypes of the vitamin D receptor (VDR) gene. Vitamin D 74-83 vitamin D receptor Homo sapiens 209-212 25595352-6 2015 CONCLUSION: In elderly selected Polish population with different genotypes of VDR polymorphisms, a statistically significant relationship between vitamin D concentration vs testosterone level was observed. Vitamin D 146-155 vitamin D receptor Homo sapiens 78-81 25560187-1 2015 The vitamin D receptor (VDR) is a mediator for the cellular effects of vitamin D and interacts with other cell signaling pathways that influence cancer development. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 25716805-2 2015 Most of vitamin D actions mediate expression of target genes regulated by nuclear vitamin D receptor (VDR). Vitamin D 8-17 vitamin D receptor Homo sapiens 82-100 25482012-1 2015 The vitamin D metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the high affinity ligand of the transcription factor vitamin D receptor (VDR) and therefore a direct regulator of transcription. Vitamin D 4-13 vitamin D receptor Homo sapiens 120-138 25482012-1 2015 The vitamin D metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the high affinity ligand of the transcription factor vitamin D receptor (VDR) and therefore a direct regulator of transcription. Vitamin D 4-13 vitamin D receptor Homo sapiens 140-143 25479835-10 2015 These findings suggest treatment with vitamin D compounds results in sustained increases in VDR in human skeletal muscle. Vitamin D 38-47 vitamin D receptor Homo sapiens 92-95 25716805-2 2015 Most of vitamin D actions mediate expression of target genes regulated by nuclear vitamin D receptor (VDR). Vitamin D 8-17 vitamin D receptor Homo sapiens 102-105 25716814-3 2015 The active form of vitamin D, 1alpha, 25-dihydroxyvitamin D3 [1,25 (OH) 2D3], regulates numerous physiological and pharmacological processes, including bone and calcium homeostasis, cellular growth and differentiation, immunity, and cardiovascular function, through binding to the vitamin D receptor (VDR), a member of the nuclear receptor superfamily. Vitamin D 19-28 vitamin D receptor Homo sapiens 281-299 25716814-3 2015 The active form of vitamin D, 1alpha, 25-dihydroxyvitamin D3 [1,25 (OH) 2D3], regulates numerous physiological and pharmacological processes, including bone and calcium homeostasis, cellular growth and differentiation, immunity, and cardiovascular function, through binding to the vitamin D receptor (VDR), a member of the nuclear receptor superfamily. Vitamin D 19-28 vitamin D receptor Homo sapiens 301-304 25716810-4 2015 Besides such a classical role, vitamin D is known to exert multiple extra-skeletal actions through CYP27B1 and vitamin D receptor (VDR) that is expressed in a wide variety of extra-renal tissues and cell types. Vitamin D 31-40 vitamin D receptor Homo sapiens 111-129 25716810-4 2015 Besides such a classical role, vitamin D is known to exert multiple extra-skeletal actions through CYP27B1 and vitamin D receptor (VDR) that is expressed in a wide variety of extra-renal tissues and cell types. Vitamin D 31-40 vitamin D receptor Homo sapiens 131-134 25716811-3 2015 Active form of vitamin D binds to nuclear or non-nuclear vitamin D receptor (VDR) and regulates the proliferation and differentiation of myoblasts through its genomic or non-genomic actions. Vitamin D 15-24 vitamin D receptor Homo sapiens 57-75 25716811-3 2015 Active form of vitamin D binds to nuclear or non-nuclear vitamin D receptor (VDR) and regulates the proliferation and differentiation of myoblasts through its genomic or non-genomic actions. Vitamin D 15-24 vitamin D receptor Homo sapiens 77-80 25028176-11 2015 This could be due to low maternal vitamin D levels in patients with GDM because in vitro low calcitriol doses upregulate VDR in trophoblast cells. Vitamin D 34-43 vitamin D receptor Homo sapiens 121-124 25499229-2 2015 Pleiotropic actions of vitamin D and its analogs are mediated by vitamin D receptor (VDR). Vitamin D 23-32 vitamin D receptor Homo sapiens 65-83 25499229-2 2015 Pleiotropic actions of vitamin D and its analogs are mediated by vitamin D receptor (VDR). Vitamin D 23-32 vitamin D receptor Homo sapiens 85-88 25499229-4 2015 The FokI and BsmI polymorphisms of the VDR gene are regarded as strong markers of disturbed vitamin D signaling pathway. Vitamin D 92-101 vitamin D receptor Homo sapiens 39-42 25662556-10 2015 Apoptosis induction of VDR+ cells in oral precancerous lesions and OSCC by natural vitamin D or synthetic vitamin D compounds could be useful for chemoprevention. Vitamin D 83-92 vitamin D receptor Homo sapiens 23-26 25662556-10 2015 Apoptosis induction of VDR+ cells in oral precancerous lesions and OSCC by natural vitamin D or synthetic vitamin D compounds could be useful for chemoprevention. Vitamin D 106-115 vitamin D receptor Homo sapiens 23-26 25887475-1 2015 BACKGROUND: The vitamin D receptor (VDR) mediates the major cellular activities of vitamin D and regulates various signaling pathways implicated in cancer development and progression. Vitamin D 16-25 vitamin D receptor Homo sapiens 36-39 25730037-1 2015 The vitamin D (1,25-dihydroxyvitamin D3) receptor (VDR) gene encodes a protein that functions in the transcriptional regulation of vitamin D-responsive genes and plays a role in innate immunity and adaptive immune responses. Vitamin D 4-13 vitamin D receptor Homo sapiens 51-54 25667505-9 2015 First results suggest that both the number of genome-wide VDR binding sites and the expression of VDR target genes correlate with vitamin D status of the studied human individuals. Vitamin D 130-139 vitamin D receptor Homo sapiens 58-61 25667505-9 2015 First results suggest that both the number of genome-wide VDR binding sites and the expression of VDR target genes correlate with vitamin D status of the studied human individuals. Vitamin D 130-139 vitamin D receptor Homo sapiens 98-101 24803230-2 2015 Vitamin D has several immunomodulatory effects through vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 55-73 24803230-2 2015 Vitamin D has several immunomodulatory effects through vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 75-78 26319903-3 2015 VDR is a crucial mediator for the cellular effects of vitamin D and conflicting data have been reported for most malignancies. Vitamin D 54-63 vitamin D receptor Homo sapiens 0-3 25407646-5 2015 Vitamin D mediates its effect through binding to vitamin D receptor (VDR), which is harbored on many human immune cells, and in this way is able to modulate immune cells activity, triggering both innate and adaptive immune responses. Vitamin D 0-9 vitamin D receptor Homo sapiens 49-67 25407646-5 2015 Vitamin D mediates its effect through binding to vitamin D receptor (VDR), which is harbored on many human immune cells, and in this way is able to modulate immune cells activity, triggering both innate and adaptive immune responses. Vitamin D 0-9 vitamin D receptor Homo sapiens 69-72 25407646-6 2015 As VDR gene polymorphisms were found to associate with AITD, the evidence links vitamin D deficiency to AITD either through gene polymorphism or by environmental factors (lack of dietary uptake and sun exposure). Vitamin D 80-89 vitamin D receptor Homo sapiens 3-6 26078251-2 2015 Vitamin D receptor (VDR) is an intracellular hormone receptor that specifically binds to the biologically active form of vitamin D, 1-alpha, 25- dihydroxyvitamin D3 [1, 25(OH)2D], and mediates its effects. Vitamin D 121-130 vitamin D receptor Homo sapiens 0-18 26078251-2 2015 Vitamin D receptor (VDR) is an intracellular hormone receptor that specifically binds to the biologically active form of vitamin D, 1-alpha, 25- dihydroxyvitamin D3 [1, 25(OH)2D], and mediates its effects. Vitamin D 121-130 vitamin D receptor Homo sapiens 20-23 25773805-1 2015 Much interest has been drawn to possible associations between vitamin D receptor (VDR) gene polymorphisms and colorectal cancer risk in conjunction with potentially protective effects of calcium and vitamin D. Vitamin D 62-71 vitamin D receptor Homo sapiens 82-85 26000293-8 2015 There is a growing body of evidence concerning the therapeutic role of vitamin D/synthetic vitamin D receptor agonists in clinical and experimental models of inflammatory bowel disease far beyond the role of calcium homeostasis and bone metabolism. Vitamin D 71-80 vitamin D receptor Homo sapiens 91-109 25773805-0 2015 Associations between vitamin D receptor (VDR) gene polymorphisms and colorectal cancer risk and effect modifications of dietary calcium and vitamin D in a Japanese population. Vitamin D 21-30 vitamin D receptor Homo sapiens 41-44 26000306-2 2015 However, the ubiquitary nature of vitamin D receptor (VDR) suggests potential for widespread effects, which has led to new research exploring the effects of vitamin D on a variety of tissues, especially in the skeletal muscle. Vitamin D 34-43 vitamin D receptor Homo sapiens 54-57 26000306-3 2015 In vitro studies have shown that the active form of vitamin D, calcitriol, acts in myocytes through genomic effects involving VDR activation in the cell nucleus to drive cellular differentiation and proliferation. Vitamin D 52-61 vitamin D receptor Homo sapiens 126-129 25483861-0 2015 Double point modified analogs of vitamin d as potent activators of vitamin D receptor. Vitamin D 33-42 vitamin D receptor Homo sapiens 67-85 25685788-2 2015 Since the function of vitamin D receptor (VDR) represents the effect of vitamin D on the body and genetic variations in VDR gene may affect its function, we aim to highlight the association of two VDR gene polymorphisms with MS susceptibility. Vitamin D 22-31 vitamin D receptor Homo sapiens 42-45 26402335-2 2015 Although many VDR ligands have been developed and shown to activate VDR in vitro and in vivo, including vitamin D derivatives and non-secosteroidal compounds, a principal adverse effect of hypercalcemia has limited their clinical application. Vitamin D 104-113 vitamin D receptor Homo sapiens 14-17 26325349-2 2015 Of significance, many immune cells are able to synthesize a biologically active form of vitamin D from circulating 25-hydroxyvitamin D with subsequent intracrine actions, and the vitamin D receptor is broadly distributed. Vitamin D 88-97 vitamin D receptor Homo sapiens 179-197 26402335-3 2015 AREAS COVERED: We summarize recent patent activity regarding VDR ligands, including vitamin D derivatives, non-secosteroidal compounds and tissue-selective prodrugs, alongside their therapeutic applications. Vitamin D 84-93 vitamin D receptor Homo sapiens 61-64 25573344-1 2015 BACKGROUND: Hereditary vitamin D-resistant rickets (HVDRR) is a rare genetic disorder caused by mutations in the vitamin D receptor (VDR) gene, which result in end-organ resistance to 1,25-(OH)2D3. Vitamin D 23-32 vitamin D receptor Homo sapiens 113-131 25573344-1 2015 BACKGROUND: Hereditary vitamin D-resistant rickets (HVDRR) is a rare genetic disorder caused by mutations in the vitamin D receptor (VDR) gene, which result in end-organ resistance to 1,25-(OH)2D3. Vitamin D 23-32 vitamin D receptor Homo sapiens 53-56 25268393-1 2015 BACKGROUND/AIMS: Low 25-hydroxyvitamin D serum levels have been associated with the severity of liver fibrosis in genotype 1 chronic hepatitis C patients (G1CHC), and experimental evidence suggested a hepatoprotective role of vitamin D via interaction with hepatic vitamin D receptor (VDR). Vitamin D 31-40 vitamin D receptor Homo sapiens 265-283 25268393-1 2015 BACKGROUND/AIMS: Low 25-hydroxyvitamin D serum levels have been associated with the severity of liver fibrosis in genotype 1 chronic hepatitis C patients (G1CHC), and experimental evidence suggested a hepatoprotective role of vitamin D via interaction with hepatic vitamin D receptor (VDR). Vitamin D 31-40 vitamin D receptor Homo sapiens 285-288 25985946-4 2015 Vitamin D signals through the vitamin D receptor (VDR), a specific zinc-finger nuclear receptor. Vitamin D 0-9 vitamin D receptor Homo sapiens 30-48 25985946-4 2015 Vitamin D signals through the vitamin D receptor (VDR), a specific zinc-finger nuclear receptor. Vitamin D 0-9 vitamin D receptor Homo sapiens 50-53 25985949-5 2015 The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD). Vitamin D 146-155 vitamin D receptor Homo sapiens 276-279 25985946-5 2015 The functions of vitamin D are characterized as genomic, mediated through the VDR transcriptional effects inside the cell nucleus, and non-genomic, when the VDR induces rapid signaling, situated on the cell membrane and/or cytoplasm. Vitamin D 17-26 vitamin D receptor Homo sapiens 78-81 25985949-5 2015 The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD). Vitamin D 146-155 vitamin D receptor Homo sapiens 276-279 25985946-5 2015 The functions of vitamin D are characterized as genomic, mediated through the VDR transcriptional effects inside the cell nucleus, and non-genomic, when the VDR induces rapid signaling, situated on the cell membrane and/or cytoplasm. Vitamin D 17-26 vitamin D receptor Homo sapiens 157-160 25985949-5 2015 The vitamin D pathway is under the control of a set of polymorphic genes that code for key enzymes which regulate the synthesis and metabolism of vitamin D (i.e. CYP27A1, GC, CYP27B1 and CYP24A1) and of genes that encode for downstream mediators of vitamin D signalling (i.e. VDR, RXR, PPAR, NCOA and SMAD). Vitamin D 4-13 vitamin D receptor Homo sapiens 276-279 25664062-4 2014 Vitamin D exerts its action via the nuclear vitamin D receptor (VDR), which shows an extensive polymorphism. Vitamin D 0-9 vitamin D receptor Homo sapiens 44-62 25378147-2 2015 Furthermore, vitamin D production and supplementation have been shown to exert protective effects via an unknown signaling mechanism involving the vitamin D receptor (VDR) in several diseases and cancer types, including skin cancer. Vitamin D 13-22 vitamin D receptor Homo sapiens 147-165 25378147-2 2015 Furthermore, vitamin D production and supplementation have been shown to exert protective effects via an unknown signaling mechanism involving the vitamin D receptor (VDR) in several diseases and cancer types, including skin cancer. Vitamin D 13-22 vitamin D receptor Homo sapiens 167-170 25541958-1 2014 BACKGROUND: Polymorphisms of genes encoding components of the vitamin D pathway including vitamin D receptor (VDR) and vitamin D binding protein (DBP) have been widely investigated because of the complex role played by vitamin D in cancer tumorogenesis. Vitamin D 62-71 vitamin D receptor Homo sapiens 90-108 25541958-1 2014 BACKGROUND: Polymorphisms of genes encoding components of the vitamin D pathway including vitamin D receptor (VDR) and vitamin D binding protein (DBP) have been widely investigated because of the complex role played by vitamin D in cancer tumorogenesis. Vitamin D 62-71 vitamin D receptor Homo sapiens 110-113 25541958-1 2014 BACKGROUND: Polymorphisms of genes encoding components of the vitamin D pathway including vitamin D receptor (VDR) and vitamin D binding protein (DBP) have been widely investigated because of the complex role played by vitamin D in cancer tumorogenesis. Vitamin D 90-99 vitamin D receptor Homo sapiens 110-113 25611831-4 2015 The biologic actions of both vitamin D and its synthetic analogues are mediated by binding to the same VDR, acting on different genes. Vitamin D 29-38 vitamin D receptor Homo sapiens 103-106 25611831-8 2015 Moreover, it considers that, in addition to selective/non selective activation of VDR for the prevention and treatment of SHPT, VDR could be activated in dialysis patients by native vitamin D or even low paricalcitol doses, independently of PTH levels, as some cohort studies and a recent metaanalysis have found an association between treatment with active vitamin D and decreased mortality in patients with CKD. Vitamin D 182-191 vitamin D receptor Homo sapiens 128-131 25611831-8 2015 Moreover, it considers that, in addition to selective/non selective activation of VDR for the prevention and treatment of SHPT, VDR could be activated in dialysis patients by native vitamin D or even low paricalcitol doses, independently of PTH levels, as some cohort studies and a recent metaanalysis have found an association between treatment with active vitamin D and decreased mortality in patients with CKD. Vitamin D 358-367 vitamin D receptor Homo sapiens 128-131 25546457-9 2014 Accordingly, treatment of HaCaT cells with vitamin D downregulated both subunits, suggesting that VDR may inhibit the respiratory chain and redirect TCA intermediates toward biosynthesis, thus contributing to the metabolic switch that is typical of cancer cells. Vitamin D 43-52 vitamin D receptor Homo sapiens 98-101 25664062-4 2014 Vitamin D exerts its action via the nuclear vitamin D receptor (VDR), which shows an extensive polymorphism. Vitamin D 0-9 vitamin D receptor Homo sapiens 64-67 25355154-3 2014 Although major targets of vitamin D action are skeletal system and mineral metabolism, vitamin D receptor is ubiquitously expressed in many tissues. Vitamin D 26-35 vitamin D receptor Homo sapiens 87-105 25460500-8 2014 Furthermore, we show that in the presence of ligand, BRCA1 associates with vitamin D receptor (VDR) and the complex co-occupies vitamin D responsive elements (VDRE) at the CDKN1A (p21waf1) promoter and enhances acetylation of histone H3 and H4 at these sites. Vitamin D 75-84 vitamin D receptor Homo sapiens 95-98 25195132-1 2014 The protective effect of vitamin D against several cancers including colorectal cancer is modulated by the vitamin D receptor (VDR) and its ligand, the active form of vitamin D. Vitamin D 25-34 vitamin D receptor Homo sapiens 107-125 25195132-1 2014 The protective effect of vitamin D against several cancers including colorectal cancer is modulated by the vitamin D receptor (VDR) and its ligand, the active form of vitamin D. Vitamin D 25-34 vitamin D receptor Homo sapiens 127-130 25195132-1 2014 The protective effect of vitamin D against several cancers including colorectal cancer is modulated by the vitamin D receptor (VDR) and its ligand, the active form of vitamin D. Vitamin D 107-116 vitamin D receptor Homo sapiens 127-130 24688000-7 2014 Third, among 24 candidate genes across vitamin D pathway, associations with BP traits that meet gene-wide significance level were found for NCOA3 (rs2235734), RXRA (rs875444), DHCR7 (rs1790370), VDR (rs2544037), and NCOR2 (rs1243733, rs1147289) in the WGHS and NCOR1, TP53BP1, and TYRP1 in the ICBP. Vitamin D 39-48 vitamin D receptor Homo sapiens 195-198 25414832-5 2014 In particular, genetic determinants innate to host intrinsic metabolic pathways such as highly polymorphic cytochromes P450s responsible for the metabolic activation of vitamin D are expressed in many organs, including the thyroid gland and can impact vitamin D interaction with its nuclear receptor (VDR) in thyroid tissue. Vitamin D 169-178 vitamin D receptor Homo sapiens 301-304 25414832-5 2014 In particular, genetic determinants innate to host intrinsic metabolic pathways such as highly polymorphic cytochromes P450s responsible for the metabolic activation of vitamin D are expressed in many organs, including the thyroid gland and can impact vitamin D interaction with its nuclear receptor (VDR) in thyroid tissue. Vitamin D 252-261 vitamin D receptor Homo sapiens 301-304 25137505-1 2014 PURPOSE OF REVIEW: To highlight recently published data about the vitamin D status of athletes, and effect of vitamin D supplementation on muscle strength and performance in the athletic population.The vitamin D receptor exists in skeletal muscle, and muscle weakness has been reported in individuals who are severely deficient [25(OH)D <25 nmol/l]. Vitamin D 66-75 vitamin D receptor Homo sapiens 202-220 25137505-1 2014 PURPOSE OF REVIEW: To highlight recently published data about the vitamin D status of athletes, and effect of vitamin D supplementation on muscle strength and performance in the athletic population.The vitamin D receptor exists in skeletal muscle, and muscle weakness has been reported in individuals who are severely deficient [25(OH)D <25 nmol/l]. Vitamin D 110-119 vitamin D receptor Homo sapiens 202-220 25059118-2 2014 Vitamin D exerts its biological effects through its interaction with the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 73-91 25059118-2 2014 Vitamin D exerts its biological effects through its interaction with the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 93-96 25771722-1 2014 The VDR gene is an important regulator of the vitamin D pathway, and the role of some of its polymorphisms on cancer risk was previously investigated. Vitamin D 46-55 vitamin D receptor Homo sapiens 4-7 24239508-1 2014 The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), suppresses the proliferation while promoting the differentiation of keratinocytes through the vitamin D receptor (VDR). Vitamin D 25-34 vitamin D receptor Homo sapiens 170-188 25353337-10 2014 VDR ApaI aa genotype was positively associated with well-controlled asthma according to GINA and C-ACT questionnaire and negatively associated with decreased limitation in daily activities in asthmatic children, further supporting the importance of Vitamin D pathway in asthma. Vitamin D 249-258 vitamin D receptor Homo sapiens 0-3 29159099-5 2014 The vitamin D metabolite, 1,25-dihydroxyvitamin D3, has been demonstrated to markedly reduce cellular proliferation especially of malignant cells that have a vitamin D receptor. Vitamin D 4-13 vitamin D receptor Homo sapiens 158-176 24937537-9 2014 RESULTS: Microarrays depicted 63 genes significantly regulated by 1,25(OH)2D3, including genes related to male androgen and vitamin D metabolism, mainly triggered by the vitamin D receptor/retinoid X receptor activation. Vitamin D 124-133 vitamin D receptor Homo sapiens 170-188 23911725-3 2014 Classically, transcriptional regulation by the VDR, similar to other nuclear receptors, has been characterized by its capacity to recognize high affinity cognate vitamin D response elements (VDREs), located in the regulatory regions of target genes. Vitamin D 162-171 vitamin D receptor Homo sapiens 47-50 24239508-1 2014 The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), suppresses the proliferation while promoting the differentiation of keratinocytes through the vitamin D receptor (VDR). Vitamin D 25-34 vitamin D receptor Homo sapiens 190-193 24239508-11 2014 These genes possess vitamin D response elements (VDRE) adjacent to TCF/beta-catenin response elements and are regulated by both VDR and beta-catenin signaling. Vitamin D 20-29 vitamin D receptor Homo sapiens 49-52 24975273-6 2014 CONCLUSION: We present a new approach to predict vitamin D target genes based on conserved genomic VDR-binding sites. Vitamin D 49-58 vitamin D receptor Homo sapiens 99-102 24859502-1 2014 OBJECTIVE: To study the vitamin D receptor (VDR) gene in five Egyptian patients with severe rickets and the clinical features of hereditary vitamin D-resistant rickets, including hypocalcemia, hypophosphatemia, total alopecia, and elevated serum levels of 1,25-dihydroxyvitamin D. Vitamin D 24-33 vitamin D receptor Homo sapiens 44-47 25194407-2 2014 The aim of present study was to evaluate the relationship between vitamin D receptor (VDR) gene FokI and ApaI polymorphisms with serum levels of fetuin-A, vitamin D, and intact PTH in hemodialysis patients. Vitamin D 66-75 vitamin D receptor Homo sapiens 86-89 25194407-10 2014 CONCLUSIONS: Our study shows that increased serum level of PTH and decreased fetuin-A and vitamin D levels may increase susceptibility of atherosclerosis in patients with hemodialysis through VDR gene FokI and ApaI polymorphisms. Vitamin D 90-99 vitamin D receptor Homo sapiens 192-195 24926821-3 2014 The level of the active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25D), is controlled in part by VDR-dependent induction of cytochrome P450, family 24, subfamily 1, polypeptide1 (CYP24A1), which metabolizes 1,25D to an inactive form. Vitamin D 38-47 vitamin D receptor Homo sapiens 113-116 25065871-1 2014 Vitamin D acts through vitamin D receptor, expressed in a variety of human tissues, including cancer tissues of various origins. Vitamin D 0-9 vitamin D receptor Homo sapiens 23-41 24742873-10 2014 Stratification according to study characteristics showed that publication year, age, gender, estimated vitamin D levels and latitude moderated significantly association between VDR polymorphisms and T1D disease. Vitamin D 103-112 vitamin D receptor Homo sapiens 177-180 25002714-12 2014 We observed interactions between 25-OHD level and VDR genotype, suggesting a causal relationship between vitamin D and survival. Vitamin D 105-114 vitamin D receptor Homo sapiens 50-53 25285313-6 2014 The vitamin D response element was significantly enriched in this system, indicating a direct regulation of this gene interaction network through the vitamin D receptor. Vitamin D 4-13 vitamin D receptor Homo sapiens 150-168 25016144-0 2014 Vitamin D supplementation promotes macrophages" anti-mycobacterial activity in type 2 diabetes mellitus patients with low vitamin D receptor expression. Vitamin D 0-9 vitamin D receptor Homo sapiens 122-140 25016144-5 2014 When Monocytes Derived Macrophages (MDM) from DM2 patients with low VDR expression were supplemented with vitamin D, MDMs eliminate efficiently M. tuberculosis. Vitamin D 106-115 vitamin D receptor Homo sapiens 68-71 24325596-1 2014 BACKGROUND: Vitamin D, certain single nucleotide polymorphisms (SNPs) in the vitamin D-receptor (VDR) gene and vitamin D metabolism genes have been associated with type 1 diabetes (T1D). Vitamin D 12-21 vitamin D receptor Homo sapiens 77-95 24325596-1 2014 BACKGROUND: Vitamin D, certain single nucleotide polymorphisms (SNPs) in the vitamin D-receptor (VDR) gene and vitamin D metabolism genes have been associated with type 1 diabetes (T1D). Vitamin D 12-21 vitamin D receptor Homo sapiens 97-100 24325596-1 2014 BACKGROUND: Vitamin D, certain single nucleotide polymorphisms (SNPs) in the vitamin D-receptor (VDR) gene and vitamin D metabolism genes have been associated with type 1 diabetes (T1D). Vitamin D 77-86 vitamin D receptor Homo sapiens 97-100 24920642-2 2014 We hypothesized that vitamin D was associated with a lower risk of colorectal cancer with high-level vitamin D receptor (VDR) expression, but not with risk of tumor with low-level VDR expression. Vitamin D 21-30 vitamin D receptor Homo sapiens 101-119 24920642-2 2014 We hypothesized that vitamin D was associated with a lower risk of colorectal cancer with high-level vitamin D receptor (VDR) expression, but not with risk of tumor with low-level VDR expression. Vitamin D 21-30 vitamin D receptor Homo sapiens 121-124 24920642-8 2014 CONCLUSIONS: A higher predicted vitamin D score was significantly associated with a lower colorectal cancer risk, regardless of VDR status and other molecular features examined. Vitamin D 32-41 vitamin D receptor Homo sapiens 128-131 24854954-1 2014 Vitamin D(3) belongs to the few nutritional compounds that has, via the binding of its metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) to the transcription factor vitamin D receptor (VDR), a direct effect on gene regulation. Vitamin D 0-9 vitamin D receptor Homo sapiens 176-194 24854954-1 2014 Vitamin D(3) belongs to the few nutritional compounds that has, via the binding of its metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) to the transcription factor vitamin D receptor (VDR), a direct effect on gene regulation. Vitamin D 0-9 vitamin D receptor Homo sapiens 196-199 24894441-0 2014 Significance of vitamin d receptor gene polymorphisms for risk of hepatocellular carcinoma in chronic hepatitis C. BACKGROUND/AIMS: Biological and epidemiological data suggest that vitamin D levels may influence cancer development. Vitamin D 181-190 vitamin D receptor Homo sapiens 16-34 24887145-10 2014 Effects of VDR or VEGF blockade were partially prevented by vitamin D. Vitamin D 60-69 vitamin D receptor Homo sapiens 11-14 24768180-3 2014 To assess for association between polymorphisms of vitamin-D pathway genes CYP27B1, vitamin-D binding protein (VDBP) and VDR with HIV-1 infection, disease progression to acquired immunodeficiency syndrome (AIDS) was analysed according to CDC93 criteria in a cohort of 185 HIV-1 seroprevalent patients belonging to the injection drug users. Vitamin D 51-60 vitamin D receptor Homo sapiens 121-124 24899504-7 2014 PPARgamma agonists reversed the antiadipogenic and the antimicrobial effects of VDR, indicating a link between VDR and PPARgamma signaling in regulating both vitamin D functions. Vitamin D 158-167 vitamin D receptor Homo sapiens 80-83 24899504-7 2014 PPARgamma agonists reversed the antiadipogenic and the antimicrobial effects of VDR, indicating a link between VDR and PPARgamma signaling in regulating both vitamin D functions. Vitamin D 158-167 vitamin D receptor Homo sapiens 111-114 24917549-1 2014 Hereditary vitamin D-resistant rickets (HVDRR) is a rare autosomal recessive disorder caused by mutations in the vitamin D receptor (VDR) gene. Vitamin D 11-20 vitamin D receptor Homo sapiens 113-131 24917549-1 2014 Hereditary vitamin D-resistant rickets (HVDRR) is a rare autosomal recessive disorder caused by mutations in the vitamin D receptor (VDR) gene. Vitamin D 11-20 vitamin D receptor Homo sapiens 41-44 24939880-7 2014 The downregulation of LCN2 expression was blunted when vitamin D receptor (VDR) was knocked down, implicating that the in vivo Lcn2 downregulation is a direct consequence of vitamin D supplementation Our results support the prevailing concept that vitamin D status is negatively associated with cancer incidence and mortality and suggest LCN2 may be a potential target against ICC. Vitamin D 55-64 vitamin D receptor Homo sapiens 75-78 24939880-7 2014 The downregulation of LCN2 expression was blunted when vitamin D receptor (VDR) was knocked down, implicating that the in vivo Lcn2 downregulation is a direct consequence of vitamin D supplementation Our results support the prevailing concept that vitamin D status is negatively associated with cancer incidence and mortality and suggest LCN2 may be a potential target against ICC. Vitamin D 174-183 vitamin D receptor Homo sapiens 55-73 24939880-7 2014 The downregulation of LCN2 expression was blunted when vitamin D receptor (VDR) was knocked down, implicating that the in vivo Lcn2 downregulation is a direct consequence of vitamin D supplementation Our results support the prevailing concept that vitamin D status is negatively associated with cancer incidence and mortality and suggest LCN2 may be a potential target against ICC. Vitamin D 174-183 vitamin D receptor Homo sapiens 75-78 24638155-2 2014 The aim of the current study was to investigate the association of VDR gene polymorphisms with melanoma risk, clinicopathological characteristics, and vitamin D levels. Vitamin D 151-160 vitamin D receptor Homo sapiens 67-70 24693968-4 2014 Individual transgenic mouse strains selectively expressed BAC-derived mouse or human VDR proteins in appropriate vitamin D target tissues, thereby recapitulating the tissue-specific expression of endogenous mouse VDR. Vitamin D 113-122 vitamin D receptor Homo sapiens 85-88 24654573-3 2014 The retiferol, disubstituted at C-13, was bound to the ligand-binding domain (LBD) of vitamin D receptor (VDR) just like the vitamin D hormone [1,25-(OH)2D3]. Vitamin D 86-95 vitamin D receptor Homo sapiens 106-109 24654573-7 2014 EXPERT OPINION: Docking experiments and molecular modeling have shown that positioning of vitamin D analog at the LBD of VDR is not disturbed by deletion of a large portion of the vitamin D, exactly as hypothesized. Vitamin D 90-99 vitamin D receptor Homo sapiens 121-124 24665943-11 2014 Some vitamin D however remains in the skin and is activated to interact with its vitamin D receptor to control cell proliferation using a variety of strategies including interacting with long non-coding RNAs to reduce risk of photocarcinogenesis. Vitamin D 5-14 vitamin D receptor Homo sapiens 81-99 24702903-9 2014 CONCLUSION: This study may support a future platform for the study of vitamin D during pregnancy and treatment of selective target populations with vitamin D and/or VDR "tissue-specific therapeutic intervention" for prevention of PTB. Vitamin D 70-79 vitamin D receptor Homo sapiens 165-168 24680778-0 2014 Association of VDR-gene variants with factors related to the metabolic syndrome, type 2 diabetes and vitamin D deficiency. Vitamin D 101-110 vitamin D receptor Homo sapiens 15-18 24680778-2 2014 This study was conducted to assess the association between vitamin D receptor (VDR) polymorphisms and genetic susceptibility to components of the metabolic syndrome, type 2 diabetes mellitus (T2DM), and vitamin D deficiency in the Saudi Arabian population. Vitamin D 59-68 vitamin D receptor Homo sapiens 79-82 24607320-2 2014 Vitamin D induces its genomic effects through its nuclear receptor the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 71-89 24607320-2 2014 Vitamin D induces its genomic effects through its nuclear receptor the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 91-94 24557774-2 2014 A number of studies have sought to define an association for disease with sequence variation in the VDR gene, encoding the ligand-activated nuclear hormone receptor for vitamin D. Vitamin D 169-178 vitamin D receptor Homo sapiens 100-103 24810167-1 2014 Alterations in vitamin D homeostasis, mainly involving its nuclear receptor (VDR), could have a role in the pathophysiology of the spine. Vitamin D 15-24 vitamin D receptor Homo sapiens 77-80 24773565-0 2014 Combination of triple bond and adamantane ring on the vitamin D side chain produced partial agonists for vitamin D receptor. Vitamin D 54-63 vitamin D receptor Homo sapiens 105-123 24773565-3 2014 To develop tissue-selective VDR modulators, we have designed vitamin D analogues with an adamantane ring at the side chain terminal, which would interfere with helix 12, the activation function 2, and modulate the VDR potency. Vitamin D 61-70 vitamin D receptor Homo sapiens 28-31 24773565-3 2014 To develop tissue-selective VDR modulators, we have designed vitamin D analogues with an adamantane ring at the side chain terminal, which would interfere with helix 12, the activation function 2, and modulate the VDR potency. Vitamin D 61-70 vitamin D receptor Homo sapiens 214-217 24860512-4 2014 Recent molecular studies have identified an extensive synergistic crosstalk between the vitamin D- and androgen-mediated mRNA and miRNA expression, adding an additional layer of post-transcriptional regulation to the known VDR- and AR-regulated gene activation. Vitamin D 88-97 vitamin D receptor Homo sapiens 223-226 24790904-2 2014 Recent research on the various molecular activities of the vitamin D system, including the nuclear vitamin D receptor and other receptors for 1,25-dihydroxyvitamin D and vitamin D metabolism, provides evidence that the vitamin D system carries out biological activities across a wide range of tissues similar to other nuclear receptor hormones. Vitamin D 59-68 vitamin D receptor Homo sapiens 99-117 24792400-0 2014 Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells. Vitamin D 0-9 vitamin D receptor Homo sapiens 27-45 24790904-7 2014 The three major bone cell types, which are osteoblasts, osteocytes and osteoclasts, can all respond to vitamin D via the classical nuclear vitamin D receptor and metabolize 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D to activate the vitamin D receptor and modulate gene expression. Vitamin D 103-112 vitamin D receptor Homo sapiens 139-157 24790904-7 2014 The three major bone cell types, which are osteoblasts, osteocytes and osteoclasts, can all respond to vitamin D via the classical nuclear vitamin D receptor and metabolize 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D to activate the vitamin D receptor and modulate gene expression. Vitamin D 103-112 vitamin D receptor Homo sapiens 236-254 24571812-1 2014 AIM: Vitamin D performs its actions through the vitamin D receptor (VDR), which acts as a transcriptional factor. Vitamin D 5-14 vitamin D receptor Homo sapiens 48-66 24558197-0 2014 Placental vitamin D receptor (VDR) expression is related to neonatal vitamin D status, placental calcium transfer, and fetal bone length in pregnant adolescents. Vitamin D 10-19 vitamin D receptor Homo sapiens 30-33 24558197-9 2014 The fetus may regulate placental VDR expression given the significant associations with neonatal vitamin D metabolites. Vitamin D 97-106 vitamin D receptor Homo sapiens 33-36 24510435-1 2014 BACKGROUND: Vitamin D plays a role in cancer tumorogenesis and acts through the vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 80-98 24510435-1 2014 BACKGROUND: Vitamin D plays a role in cancer tumorogenesis and acts through the vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 100-103 24571812-1 2014 AIM: Vitamin D performs its actions through the vitamin D receptor (VDR), which acts as a transcriptional factor. Vitamin D 5-14 vitamin D receptor Homo sapiens 68-71 24154811-4 2014 Accumulating evidence now suggests that in addition to maintaining skeletal integrity, vitamin D also plays an integral role in regulating the general immune response, a function employed via its genomic actions on the vitamin D receptor (VDR). Vitamin D 87-96 vitamin D receptor Homo sapiens 219-237 24154811-4 2014 Accumulating evidence now suggests that in addition to maintaining skeletal integrity, vitamin D also plays an integral role in regulating the general immune response, a function employed via its genomic actions on the vitamin D receptor (VDR). Vitamin D 87-96 vitamin D receptor Homo sapiens 239-242 24154811-5 2014 The VDR is expressed in all immune cells and both directly and indirectly targeted by the bioactive form of vitamin D, 1,25-Dihydroxyvitamin D (1,25[OH]2D). Vitamin D 108-117 vitamin D receptor Homo sapiens 4-7 24508736-3 2014 We hypothesize that vitamin D acts on myocytes via the VDR, and we examine proposed effects on myocyte proliferation, differentiation, growth, and inflammation. Vitamin D 20-29 vitamin D receptor Homo sapiens 55-58 24408013-1 2014 The vitamin D receptor (VDR) can influence cancer susceptibility through binding to vitamin D. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 24795646-3 2014 The description of increased vitamin D receptor (VDR) and 1alpha-hydroxylase (CYP27B1) expression in macrophages following a pathogen challenge, has underlined the importance of intracrine vitamin D as key mediator of innate immune function. Vitamin D 29-38 vitamin D receptor Homo sapiens 49-52 24808866-7 2014 Firstly, critical genes in the vitamin D signaling system, such as those coding for vitamin D receptor (VDR) and the enzymes 25-hydroxylase (CYP2R1), 1alpha-hydroxylase (CYP27B1), and 24-hydroxylase (CYP24A1) have large CpG islands in their promoter regions and therefore can be silenced by DNA methylation. Vitamin D 31-40 vitamin D receptor Homo sapiens 84-102 24808866-7 2014 Firstly, critical genes in the vitamin D signaling system, such as those coding for vitamin D receptor (VDR) and the enzymes 25-hydroxylase (CYP2R1), 1alpha-hydroxylase (CYP27B1), and 24-hydroxylase (CYP24A1) have large CpG islands in their promoter regions and therefore can be silenced by DNA methylation. Vitamin D 31-40 vitamin D receptor Homo sapiens 104-107 24808867-10 2014 In conclusion, a genome-wide (over)view on the genomic locations of VDR provides a broader basis for addressing vitamin D"s role in health and disease. Vitamin D 112-121 vitamin D receptor Homo sapiens 68-71 24851888-14 2014 Using Logistic regression analysis, it was found that mutant genotype (GA/AA) of VDR (Bsm I) played an independently protective role in UC (OR = 0.328, P = 0.028) while mutant genotype (TC/CC) of VDR (Fok I) and vitamin D deficiency (<50.0 nmol/L) had an interaction in UC (OR = 2.070, P = 0.006). Vitamin D 212-221 vitamin D receptor Homo sapiens 81-84 23681781-0 2014 Stable expression of human VDR in murine VDR-null cells recapitulates vitamin D mediated anti-cancer signaling. Vitamin D 70-79 vitamin D receptor Homo sapiens 27-30 24736069-11 2014 Treatment with TSA increased H3K4me2 and H3K9ac and simultaneously decreased H3K9me2 at the CYP24A1 promoter and treatment with 5-Aza and/or TSA increased the recruitment of vitamin D receptor (VDR) to vitamin D response elements (VDRE) of the CYP24A1 promoter. Vitamin D 174-183 vitamin D receptor Homo sapiens 194-197 23681781-5 2014 KO cells expressing hVDR with the G46D point mutation, which abrogates VDR binding to DR3 response elements, exhibited partial growth inhibition in response to 1,25D and synthetic vitamin D analogs, providing proof of principle that VDR signaling through alternative genomic or non-genomic mechanisms contributes to vitamin D mediated growth effects in transformed cells. Vitamin D 180-189 vitamin D receptor Homo sapiens 21-24 23681781-5 2014 KO cells expressing hVDR with the G46D point mutation, which abrogates VDR binding to DR3 response elements, exhibited partial growth inhibition in response to 1,25D and synthetic vitamin D analogs, providing proof of principle that VDR signaling through alternative genomic or non-genomic mechanisms contributes to vitamin D mediated growth effects in transformed cells. Vitamin D 316-325 vitamin D receptor Homo sapiens 21-24 23368852-11 2014 CONCLUSION: The association between vitamin D deficiency and MCC characteristics and outcome, together with detection of the VDR in MCC cells, suggest that vitamin D could influence the biology of MCC. Vitamin D 156-165 vitamin D receptor Homo sapiens 125-128 24529992-6 2014 1,25(OH)2D is the ligand for the vitamin D receptor (VDR), a transcription factor, binding to sites in the DNA called vitamin D response elements (VDREs). Vitamin D 33-42 vitamin D receptor Homo sapiens 53-56 24618509-1 2014 FokI and BsmI polymorphisms of vitamin D receptor (VDR) gene are regarded as reliable markers of disturbed vitamin D signaling pathway. Vitamin D 31-40 vitamin D receptor Homo sapiens 51-54 24318991-2 2014 The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 24818002-1 2014 Heterogeneous loss of function mutations in the vitamin D receptor (VDR) interfere with vitamin D signaling and cause hereditary vitamin D-resistant rickets (HVDRR). Vitamin D 48-57 vitamin D receptor Homo sapiens 68-71 24818002-1 2014 Heterogeneous loss of function mutations in the vitamin D receptor (VDR) interfere with vitamin D signaling and cause hereditary vitamin D-resistant rickets (HVDRR). Vitamin D 88-97 vitamin D receptor Homo sapiens 48-66 24818002-1 2014 Heterogeneous loss of function mutations in the vitamin D receptor (VDR) interfere with vitamin D signaling and cause hereditary vitamin D-resistant rickets (HVDRR). Vitamin D 88-97 vitamin D receptor Homo sapiens 68-71 24419359-2 2014 The spectrum of vitamin D target organs has expanded and the reproductive role of vitamin D is highlighted by expression of the vitamin D receptor (VDR) and enzymes that metabolize vitamin D in testis, male reproductive tract and human spermatozoa. Vitamin D 16-25 vitamin D receptor Homo sapiens 128-146 24269661-1 2014 Primary cultures of human bone and vascular cells respond to vitamin D treatment by modulation of cell proliferation measured by DNA synthesis (DNA) and energy metabolism measured by creatine kinase specific activity (CK) via binding to vitamin D receptors (VDR) which are expressed in these cells. Vitamin D 61-70 vitamin D receptor Homo sapiens 237-256 24269661-1 2014 Primary cultures of human bone and vascular cells respond to vitamin D treatment by modulation of cell proliferation measured by DNA synthesis (DNA) and energy metabolism measured by creatine kinase specific activity (CK) via binding to vitamin D receptors (VDR) which are expressed in these cells. Vitamin D 61-70 vitamin D receptor Homo sapiens 258-261 24269661-2 2014 Vitamin D compounds also modulate the response to estradiol-17beta (E2) and the expression mRNAs of estrogen receptors (ERalpha and ERbeta), VDR, 25-hydroxy vitamin D3 1-alpha hydroxylase (1OHase) and lipoxygenases (12LO and 15LO). Vitamin D 0-9 vitamin D receptor Homo sapiens 141-144 24316428-2 2014 Vitamin D elicits its bioactive actions by binding to its receptor, vitamin D receptor (VDR), on target cells and organs. Vitamin D 0-9 vitamin D receptor Homo sapiens 68-86 24316428-2 2014 Vitamin D elicits its bioactive actions by binding to its receptor, vitamin D receptor (VDR), on target cells and organs. Vitamin D 0-9 vitamin D receptor Homo sapiens 88-91 24419359-2 2014 The spectrum of vitamin D target organs has expanded and the reproductive role of vitamin D is highlighted by expression of the vitamin D receptor (VDR) and enzymes that metabolize vitamin D in testis, male reproductive tract and human spermatozoa. Vitamin D 82-91 vitamin D receptor Homo sapiens 128-146 24419359-2 2014 The spectrum of vitamin D target organs has expanded and the reproductive role of vitamin D is highlighted by expression of the vitamin D receptor (VDR) and enzymes that metabolize vitamin D in testis, male reproductive tract and human spermatozoa. Vitamin D 82-91 vitamin D receptor Homo sapiens 148-151 24419359-2 2014 The spectrum of vitamin D target organs has expanded and the reproductive role of vitamin D is highlighted by expression of the vitamin D receptor (VDR) and enzymes that metabolize vitamin D in testis, male reproductive tract and human spermatozoa. Vitamin D 82-91 vitamin D receptor Homo sapiens 128-146 24419359-2 2014 The spectrum of vitamin D target organs has expanded and the reproductive role of vitamin D is highlighted by expression of the vitamin D receptor (VDR) and enzymes that metabolize vitamin D in testis, male reproductive tract and human spermatozoa. Vitamin D 82-91 vitamin D receptor Homo sapiens 148-151 24419359-5 2014 Expression of VDR and enzymes that metabolize vitamin D in fetal testis indicates a yet unknown role during development, which may be extrapolated from invasive testicular germ cell tumours where 1alpha,25-dihydroxyvitamin D induces a mesodermal differentiation of the pluripotent testicular cancer cells. Vitamin D 46-55 vitamin D receptor Homo sapiens 14-17 24419359-2 2014 The spectrum of vitamin D target organs has expanded and the reproductive role of vitamin D is highlighted by expression of the vitamin D receptor (VDR) and enzymes that metabolize vitamin D in testis, male reproductive tract and human spermatozoa. Vitamin D 16-25 vitamin D receptor Homo sapiens 148-151 24436433-3 2014 The active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D, binds to the vitamin D receptor that regulates numerous genes involved in fundamental processes of potential relevance to cardiovascular disease, including cell proliferation and differentiation, apoptosis, oxidative stress, membrane transport, matrix homeostasis, and cell adhesion. Vitamin D 25-34 vitamin D receptor Homo sapiens 79-97 24370753-2 2014 Vitamin D compounds are known to suppress T-cell activation by binding to vitamin D receptor (VDR); and thus, VDR gene polymorphisms may be related to T-cell-mediated autoimmune diseases. Vitamin D 0-9 vitamin D receptor Homo sapiens 74-92 24370753-2 2014 Vitamin D compounds are known to suppress T-cell activation by binding to vitamin D receptor (VDR); and thus, VDR gene polymorphisms may be related to T-cell-mediated autoimmune diseases. Vitamin D 0-9 vitamin D receptor Homo sapiens 94-97 24370753-2 2014 Vitamin D compounds are known to suppress T-cell activation by binding to vitamin D receptor (VDR); and thus, VDR gene polymorphisms may be related to T-cell-mediated autoimmune diseases. Vitamin D 0-9 vitamin D receptor Homo sapiens 110-113 24370753-3 2014 The aim of this study was to investigate the association between vitamin D status and VDR gene polymorphisms and T1DM. Vitamin D 65-74 vitamin D receptor Homo sapiens 86-89 24586832-3 2014 We report that SENP1 and SENP2 strikingly potentiate ligand-mediated transactivation of VDR and also its heterodimeric partner, retinoid X receptor (RXRalpha) with depletion of cellular SENP1 significantly diminishing the hormonal responsiveness of the endogenous vitamin D target gene CYP24A1. Vitamin D 264-273 vitamin D receptor Homo sapiens 88-91 24586832-5 2014 In support of their function as novel modulators of the vitamin D hormonal pathway we demonstrate that both SENP1 and SENP2 can interact with VDR and reverse its modification with SUMO2. Vitamin D 56-65 vitamin D receptor Homo sapiens 142-145 24586832-7 2014 In combination, our results support a repressor function for SUMOylation of VDR and reveal SENPs as a novel class of VDR/RXR co-regulatory protein that significantly modulate the vitamin D response and which could also have important impact upon the functionality of both RXR-containing homo and heterodimers. Vitamin D 179-188 vitamin D receptor Homo sapiens 76-79 24586832-7 2014 In combination, our results support a repressor function for SUMOylation of VDR and reveal SENPs as a novel class of VDR/RXR co-regulatory protein that significantly modulate the vitamin D response and which could also have important impact upon the functionality of both RXR-containing homo and heterodimers. Vitamin D 179-188 vitamin D receptor Homo sapiens 117-120 24486205-1 2014 1alpha,25-Dihydroxyvitamin D3 [1alpha,25(OH)2D3: 1] is a specific modulator of nuclear vitamin D receptor (VDR), and novel vitamin D analogs are therapeutic candidates for multiple clinical applications. Vitamin D 19-28 vitamin D receptor Homo sapiens 87-105 24486205-1 2014 1alpha,25-Dihydroxyvitamin D3 [1alpha,25(OH)2D3: 1] is a specific modulator of nuclear vitamin D receptor (VDR), and novel vitamin D analogs are therapeutic candidates for multiple clinical applications. Vitamin D 19-28 vitamin D receptor Homo sapiens 107-110 24122604-1 2014 Since the discovery that the enzyme catalyzing the synthesis of the most active natural vitamin D metabolite(calcitriol) and the vitamin D-specific receptor (VDR)were expressed in a wide range of tissues and organs, not only involved in the mineral metabolism (MM), there has been increasing interest on the putative "non classical" roles of vitamin D metabolites, particularly on their possible effects on the cardiovascular (CV) system. Vitamin D 88-97 vitamin D receptor Homo sapiens 158-161 24122604-1 2014 Since the discovery that the enzyme catalyzing the synthesis of the most active natural vitamin D metabolite(calcitriol) and the vitamin D-specific receptor (VDR)were expressed in a wide range of tissues and organs, not only involved in the mineral metabolism (MM), there has been increasing interest on the putative "non classical" roles of vitamin D metabolites, particularly on their possible effects on the cardiovascular (CV) system. Vitamin D 129-138 vitamin D receptor Homo sapiens 158-161 24428861-3 2014 Clinical research suggests that vitamin D treatment can improve compromised human muscular ability and increase muscle size, supported by loss of motor function and muscle mass in animals following VDR knockout, as well as increased muscle protein synthesis and ATP production following vitamin D supplementation. Vitamin D 32-41 vitamin D receptor Homo sapiens 198-201 24219580-9 2014 Vitamin D deficiency and its association with VDR gene polymorphisms may be useful to identify the high-risk group individuals. Vitamin D 0-9 vitamin D receptor Homo sapiens 46-49 24248540-1 2014 The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 24553867-3 2014 Vitamin D is through stimulating vitamin D receptor to form a transcriptional complex with cofactors to modulate approximately 3% gene transcription. Vitamin D 0-9 vitamin D receptor Homo sapiens 33-51 24020384-9 2014 In particular, we highlight the emerging roles of aryl hydrocarbon (AHR), vitamin D (VDR), glucocorticoid (GR) and pregnane X (PXR) receptors in that regulation. Vitamin D 74-83 vitamin D receptor Homo sapiens 85-88 24127289-2 2014 These effects are mediated by the active form of vitamin D, 1,25(OH)2D3, which binds to a cytoplasmic protein called vitamin D receptor (VDR). Vitamin D 49-58 vitamin D receptor Homo sapiens 117-135 24127289-2 2014 These effects are mediated by the active form of vitamin D, 1,25(OH)2D3, which binds to a cytoplasmic protein called vitamin D receptor (VDR). Vitamin D 49-58 vitamin D receptor Homo sapiens 137-140 23869781-9 2014 Based on these results, we conclude that (1) high affinity for VDR, (2) resistance to CYP24A1-dependent catabolism, (3) low affinity for DBP, and (4) low calcemic effect may be required for designing potent vitamin D analogs for cancer treatment. Vitamin D 207-216 vitamin D receptor Homo sapiens 63-66 25566549-6 2014 Secondly, detail description of photoproduction of vitamin D, its subsequent metabolism and interaction with vitamin D receptor VDR, provided mechanistic background for future discoveries. Vitamin D 51-60 vitamin D receptor Homo sapiens 109-127 25566549-6 2014 Secondly, detail description of photoproduction of vitamin D, its subsequent metabolism and interaction with vitamin D receptor VDR, provided mechanistic background for future discoveries. Vitamin D 51-60 vitamin D receptor Homo sapiens 128-131 23941558-5 2014 First, we demonstrated that human fetal lung (HFL)-1 cells express the vitamin D receptor (VDR) and that vitamin D, 25-hydroxyvitamin D [25(OH)D], or 1,25-dihydroxyvitamin D [1,25(OH)2D] induce VDR nuclear translocation and increase VDR-DNA binding activity. Vitamin D 71-80 vitamin D receptor Homo sapiens 91-94 24466411-2 2014 A full vitamin D (refers to vitamin D2 and D3) endocrine system, characterized by a specific VDR (vitamin D receptor, member of the nuclear receptor family), specific vitamin D metabolizing CYP450 enzymes regulated by calciotropic hormones and a dedicated plasma transport-protein is only found in vertebrates. Vitamin D 7-16 vitamin D receptor Homo sapiens 93-96 24466411-2 2014 A full vitamin D (refers to vitamin D2 and D3) endocrine system, characterized by a specific VDR (vitamin D receptor, member of the nuclear receptor family), specific vitamin D metabolizing CYP450 enzymes regulated by calciotropic hormones and a dedicated plasma transport-protein is only found in vertebrates. Vitamin D 7-16 vitamin D receptor Homo sapiens 98-116 24466411-3 2014 In the earliest vertebrates (lamprey), vitamin D metabolism and VDR may well have originated from a duplication of a common PRX/VDR ancestor gene as part of a xenobiotic detoxification pathway. Vitamin D 39-48 vitamin D receptor Homo sapiens 128-131 25207361-2 2014 The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 25207368-17 2014 Interestingly, increasing evidence now demonstrates an important function of the vitamin D endocrine system (VDES) for prevention of BCC, SCC and melanoma, identifying the vitamin D receptor as a tumor suppressor in the skin. Vitamin D 81-90 vitamin D receptor Homo sapiens 172-190 25207372-2 2014 The major cell in the epidermis, the keratinocyte, not only produces vitamin D but contains the enzymatic machinery to metabolize vitamin D to its active metabolite, 1,25(OH)2D, and expresses the receptor for this metabolite, the vitamin D receptor (VDR), allowing the cell to respond to the 1,25(OH)2D that it produces. Vitamin D 130-139 vitamin D receptor Homo sapiens 230-248 25207372-2 2014 The major cell in the epidermis, the keratinocyte, not only produces vitamin D but contains the enzymatic machinery to metabolize vitamin D to its active metabolite, 1,25(OH)2D, and expresses the receptor for this metabolite, the vitamin D receptor (VDR), allowing the cell to respond to the 1,25(OH)2D that it produces. Vitamin D 130-139 vitamin D receptor Homo sapiens 250-253 25207372-8 2014 In this chapter we will first discuss recent data regarding potential mechanisms by which vitamin D signaling suppresses tumor formation, then focus on three general mechanisms that mediate tumor suppression by VDR in the skin: inhibition of proliferation and stimulation of differentiation, immune regulation, and stimulation of DNA damage repair (DDR). Vitamin D 90-99 vitamin D receptor Homo sapiens 211-214 25207373-4 2014 In addition to these known responses, there is now sufficient evidence to suggest that the local vitamin D system in skin, which includes local production of the active hormone, 1,25 dihydroxyvitamin D, together with metabolites of over-irradiation products, and vitamin D receptor(s), also provide an adaptive response to UV. Vitamin D 97-106 vitamin D receptor Homo sapiens 263-281 25227839-2 2014 Vitamin D may have an anticancer effect in colorectal cancer mediated by binding of the active form 1,25(OH)2D to the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 118-136 25227839-2 2014 Vitamin D may have an anticancer effect in colorectal cancer mediated by binding of the active form 1,25(OH)2D to the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 138-141 24948018-5 2014 It also uncovered the molecular aspects of vitamin D action, from its nuclear receptor, VDR, to the various target genes of this hormone. Vitamin D 43-52 vitamin D receptor Homo sapiens 88-91 25197630-6 2014 Recent studies suggest that vitamin D receptor (VDR) might be expressed in muscle fibers and vitamin D signaling via VDR plays a role in the regulation of myoblast proliferation and differentiation. Vitamin D 28-37 vitamin D receptor Homo sapiens 48-51 24200978-1 2014 Previous studies have identified several common genetic variants in VDR, GC and CYP2R1 to be associated with circulating levels of 25-hydroxyvitamin D [25(OH)D] and vitamin D deficiency in Western populations. Vitamin D 141-150 vitamin D receptor Homo sapiens 68-71 24597598-4 2014 VDR activators (calcitriol and paricalcitol) are available for the treatment of vitamin D deficiency, which can result from inadequate cutaneous production and/or low dietary intake. Vitamin D 80-89 vitamin D receptor Homo sapiens 0-3 25537068-0 2014 Development of vitamin D analogs modulating the pocket structure of vitamin D receptor. Vitamin D 15-24 vitamin D receptor Homo sapiens 68-86 24438630-7 2014 Mounting evidences from animal and clinical studies have suggested that vitamin D therapy has beneficial effects on the renal systems and the underlying renoprotective mechanisms of the vitamin D receptor-mediated signaling pathways is a hot research topic. Vitamin D 72-81 vitamin D receptor Homo sapiens 186-204 24200978-0 2014 Serum 25(OH)D and vitamin D status in relation to VDR, GC and CYP2R1 variants in Chinese. Vitamin D 18-27 vitamin D receptor Homo sapiens 50-53 24699387-7 2014 These same genes were associated with several late-life phenotypes: VDR-BsmI, TaqI and ApaI determined the relationship between dietary vitamin D and both insulin (P < 0.0001/BB, 0.0007/tt and 0.0173/AA, respectively) and systolic blood pressure (P = 0.0290/Bb, 0.0299/Tt and 0.0412/AA, respectively), making them important early and late in the lifecycle. Vitamin D 136-145 vitamin D receptor Homo sapiens 68-71 25060608-1 2014 BACKGROUND/AIMS: We analyzed the vitamin D receptor (VDR) gene in 2 Greek patients who exhibited the classical features of hereditary vitamin D-resistant rickets (HVDRR) type II, including severe bone deformities and alopecia. Vitamin D 33-42 vitamin D receptor Homo sapiens 53-56 24010964-0 2013 Novel targets of vitamin D activity in bone: action of the vitamin D receptor in osteoblasts, osteocytes and osteoclasts. Vitamin D 17-26 vitamin D receptor Homo sapiens 59-77 23564710-1 2014 The vitamin D signal transduction system involves a series of cytochrome P450-containing sterol hydroxylases to generate and degrade the active hormone, 1alpha,25-dihydroxyvitamin D3, which serves as a ligand for the vitamin D receptor-mediated transcriptional gene expression described in companion articles in this review series. Vitamin D 4-13 vitamin D receptor Homo sapiens 217-235 25969372-0 2014 Vitamin D Receptor Genotype Modulates the Correlation between Vitamin D and Circulating Levels of let-7a/b and Vitamin D Intake in an Elderly Cohort. Vitamin D 62-71 vitamin D receptor Homo sapiens 0-18 25969372-12 2014 CONCLUSIONS: The correlation between vitamin D intake and let-7a/b expression in this cohort varies with VDR genotype. Vitamin D 37-46 vitamin D receptor Homo sapiens 105-108 24246681-1 2014 CONTEXT: Hereditary vitamin D resistant rickets (HVDRR), also known as vitamin D-dependent rickets type II, is an autosomal recessive disorder characterized by the early onset of rickets with hypocalcemia, secondary hyperparathyroidism and hypophosphatemia and is caused by mutations in the vitamin D receptor (VDR) gene. Vitamin D 20-29 vitamin D receptor Homo sapiens 291-309 24246681-1 2014 CONTEXT: Hereditary vitamin D resistant rickets (HVDRR), also known as vitamin D-dependent rickets type II, is an autosomal recessive disorder characterized by the early onset of rickets with hypocalcemia, secondary hyperparathyroidism and hypophosphatemia and is caused by mutations in the vitamin D receptor (VDR) gene. Vitamin D 20-29 vitamin D receptor Homo sapiens 50-53 24246681-1 2014 CONTEXT: Hereditary vitamin D resistant rickets (HVDRR), also known as vitamin D-dependent rickets type II, is an autosomal recessive disorder characterized by the early onset of rickets with hypocalcemia, secondary hyperparathyroidism and hypophosphatemia and is caused by mutations in the vitamin D receptor (VDR) gene. Vitamin D 71-80 vitamin D receptor Homo sapiens 291-309 24246681-1 2014 CONTEXT: Hereditary vitamin D resistant rickets (HVDRR), also known as vitamin D-dependent rickets type II, is an autosomal recessive disorder characterized by the early onset of rickets with hypocalcemia, secondary hyperparathyroidism and hypophosphatemia and is caused by mutations in the vitamin D receptor (VDR) gene. Vitamin D 71-80 vitamin D receptor Homo sapiens 50-53 26168131-4 2014 The vitamin D receptor (VDR) as a steroid hormone superfamily of nuclear receptors is highly expressed in epithelial cells at risk for carcinogenesis, providing a direct molecular link by which vitamin D status impacts on carcinogenesis. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 26168131-5 2014 Because VDR expression is retained in many human tumors, vitamin D status may be an important modulator of cancer progression in persons living with cancer. Vitamin D 57-66 vitamin D receptor Homo sapiens 8-11 24048755-1 2014 Vitamin D receptor (VDR) principally mediates the anticancer activities of vitamin D. Vitamin D 75-84 vitamin D receptor Homo sapiens 0-18 24048755-1 2014 Vitamin D receptor (VDR) principally mediates the anticancer activities of vitamin D. Vitamin D 75-84 vitamin D receptor Homo sapiens 20-23 24105653-9 2014 Hence, we provide mechanistic insight that the FokI VDR polymorphism renders STAT1-mediated antiviral immune reactions to RSV infection non-responsive to vitamin D control, resulting in enhanced immunopathology and exacerbated RSV bronchiolitis. Vitamin D 154-163 vitamin D receptor Homo sapiens 52-55 24284821-8 2014 Our data demonstrate the importance of intact VDR signaling in the preservation of vascular function and may provide a mechanistic explanation for epidemiological data in humans showing that vitamin D insufficiency is associated with hypertension and endothelial dysfunction. Vitamin D 191-200 vitamin D receptor Homo sapiens 46-49 24010964-1 2013 The active form of vitamin D, 1,25-dihydroxyvitamin D3, carries out its diverse range of biological activities by binding to the nuclear vitamin D receptor, present in almost every cell of the body. Vitamin D 19-28 vitamin D receptor Homo sapiens 137-155 24078452-1 2013 The polymorphism of vitamin D receptor (VDR) gene is demonstrated to affect the activity of its encoding protein and the subsequent downstream effects mediated by vitamin D. Vitamin D 20-29 vitamin D receptor Homo sapiens 40-43 24102630-1 2013 Vitamin D acts through binding with vitamin D receptor (VDR) and is responsible for regulating bone metabolism and mineralization; it also suppresses the immune system. Vitamin D 0-9 vitamin D receptor Homo sapiens 36-54 24102630-1 2013 Vitamin D acts through binding with vitamin D receptor (VDR) and is responsible for regulating bone metabolism and mineralization; it also suppresses the immune system. Vitamin D 0-9 vitamin D receptor Homo sapiens 56-59 24067280-3 2013 Current research has been focused on identification of new variants of genes involved in vitamin D pathway, namely in vitamin D receptor and enzymes of vitamin D metabolism. Vitamin D 89-98 vitamin D receptor Homo sapiens 118-136 24108316-11 2013 Further work is needed to determine whether the observed effect of vitamin D on fiber size is mediated by the VDR and to identify which signaling pathways are involved. Vitamin D 67-76 vitamin D receptor Homo sapiens 110-113 24386512-3 2013 In this report, in vitro and in vivo anticancer efficacy, safety, and details of vitamin D receptor (VDR) interactions of PT19c, a novel nonhypercalcemic vitamin D derived anticancer agent, are described. Vitamin D 81-90 vitamin D receptor Homo sapiens 101-104 23945129-2 2013 Currently, several genes have been associated with SLE susceptibility, including vitamin D receptor (VDR), which is a mediator of immune responses through the action of vitamin D. Vitamin D 81-90 vitamin D receptor Homo sapiens 101-104 23500379-0 2013 Relationship between vitamin D receptor gene (VDR) polymorphisms, vitamin D status, osteoarthritis and intervertebral disc degeneration. Vitamin D 21-30 vitamin D receptor Homo sapiens 46-49 23500379-8 2013 In the future, given the role of vitamin D system in the cartilaginous tissue metabolism, it could be interesting to perform functional and tissue specific studies to analyze the interplay between the different VDR variants and its ligand. Vitamin D 33-42 vitamin D receptor Homo sapiens 211-214 23381556-2 2013 Some studies have reported associations between vitamin D pathway genes such as VDR, GC and CYP27B1 with body mass index (BMI) and waist circumference (WC); however, the findings have been inconsistent. Vitamin D 48-57 vitamin D receptor Homo sapiens 80-83 23911750-1 2013 Vitamin D activity requires an adequate vitamin D status as indicated by the serum level of 25-hydroxyvitamin D and appropriate expression of genes coding for vitamin D receptor and 25-hydroxyvitamin D 1alpha-hydroxylase, the enzyme which converts 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D. Vitamin D 0-9 vitamin D receptor Homo sapiens 159-177 24251203-7 2013 The results indicate a potential antidiabetic function of vitamin D on GLUT1, GLUT4, VDR, and IR by improving receptor gene expression suggesting a role for vitamin D in regulation of expression of the glucose transporters in muscle cells. Vitamin D 58-67 vitamin D receptor Homo sapiens 85-88 23945129-3 2013 Polymorphisms in the VDR gene can impair the vitamin D (D3) function role, and since SLE patients show deficient D3 blood levels, it leads to a possible connection to the disease"s onset. Vitamin D 45-54 vitamin D receptor Homo sapiens 21-24 23906633-6 2013 Here we show, using human patient samples from individuals with hereditary vitamin D resistant rickets, that the VDR directly inhibits the expression of uncoupling protein-1 (UCP1), the critical protein for uncoupling fatty acid oxidation in brown fat and burning energy. Vitamin D 75-84 vitamin D receptor Homo sapiens 113-116 23849224-15 2013 Our results also suggest that VDR binding in response to physiological levels of vitamin D occurs predominantly in a VDR motif-independent manner. Vitamin D 81-90 vitamin D receptor Homo sapiens 30-33 24051166-5 2013 Many non-classical effects of vitamin D are suggested by the quasi-ubiquitous presence of the vitamin D receptor and by myriads of studies showing an association between vitamin D deficiency/insufficiency and an increased incidence or a poor prognostic of many diseases. Vitamin D 30-39 vitamin D receptor Homo sapiens 94-112 24084050-8 2013 Two variants: rs731236[A] (VDR) and rs732594[A] (SCUBE3) showed a significant association with serum Vit D levels in CD patients. Vitamin D 101-106 vitamin D receptor Homo sapiens 27-30 23944708-0 2013 Crystal structures of hereditary vitamin D-resistant rickets-associated vitamin D receptor mutants R270L and W282R bound to 1,25-dihydroxyvitamin D3 and synthetic ligands. Vitamin D 33-42 vitamin D receptor Homo sapiens 72-90 23944708-2 2013 Hereditary vitamin D-resistant rickets (HVDRR), an autosomal recessive disease, is caused by mutations in the VDR. Vitamin D 11-20 vitamin D receptor Homo sapiens 41-44 24119849-3 2013 Mounting evidence from animal and clinical studies has shown beneficial effects of vitamin D therapy on the renal and cardiovascular systems, and the underlying renoprotective and cardioprotective mechanisms of vitamin D receptor (VDR)-mediated signaling are under intense investigation. Vitamin D 83-92 vitamin D receptor Homo sapiens 231-234 23232694-4 2013 We studied TFIIH-dependent transactivation by nuclear receptor for vitamin D (VDR) and thyroid in cells from these patients. Vitamin D 67-76 vitamin D receptor Homo sapiens 78-81 23807674-1 2013 The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 23721405-1 2013 Vitamin D receptor is a mediator of immune responses through the action of vitamin D, which is capable of regulate the insulin secretion by the pancreas. Vitamin D 75-84 vitamin D receptor Homo sapiens 0-18 23721405-2 2013 Since polymorphisms in the vitamin D receptor (VDR) gene might modulate vitamin D function, and thus immunologic response, VDR is possibly able to influence the predisposition to type 1 diabetes mellitus (T1DM). Vitamin D 27-36 vitamin D receptor Homo sapiens 47-50 23721405-2 2013 Since polymorphisms in the vitamin D receptor (VDR) gene might modulate vitamin D function, and thus immunologic response, VDR is possibly able to influence the predisposition to type 1 diabetes mellitus (T1DM). Vitamin D 27-36 vitamin D receptor Homo sapiens 123-126 23849224-15 2013 Our results also suggest that VDR binding in response to physiological levels of vitamin D occurs predominantly in a VDR motif-independent manner. Vitamin D 81-90 vitamin D receptor Homo sapiens 117-120 23877860-3 2013 PATIENTS AND METHODS: We studied in a cohort of 91 HIV-infected Italian patients the metabolism of Vitamin D by evaluating the in vitro expression of CYP27B1, CYP24A1 and vitamin D receptor (VDR) by monocytes and macrophages stimulated with the viral envelope protein gp120 or lipopolysaccharide (LPS). Vitamin D 99-108 vitamin D receptor Homo sapiens 171-189 23857228-1 2013 The role of vitamin D in maintaining health appears greater than originally thought, and the concept of the vitamin D axis underlines the complexity of the biological events controlled by biologically active vitamin D (1,25(OH)(2)D3), its two binding proteins that are the vitamin D receptor (VDR) and the vitamin D-binding protein-derived macrophage activating factor (GcMAF). Vitamin D 108-117 vitamin D receptor Homo sapiens 273-291 23857228-1 2013 The role of vitamin D in maintaining health appears greater than originally thought, and the concept of the vitamin D axis underlines the complexity of the biological events controlled by biologically active vitamin D (1,25(OH)(2)D3), its two binding proteins that are the vitamin D receptor (VDR) and the vitamin D-binding protein-derived macrophage activating factor (GcMAF). Vitamin D 108-117 vitamin D receptor Homo sapiens 293-296 23857228-1 2013 The role of vitamin D in maintaining health appears greater than originally thought, and the concept of the vitamin D axis underlines the complexity of the biological events controlled by biologically active vitamin D (1,25(OH)(2)D3), its two binding proteins that are the vitamin D receptor (VDR) and the vitamin D-binding protein-derived macrophage activating factor (GcMAF). Vitamin D 108-117 vitamin D receptor Homo sapiens 273-291 23857228-1 2013 The role of vitamin D in maintaining health appears greater than originally thought, and the concept of the vitamin D axis underlines the complexity of the biological events controlled by biologically active vitamin D (1,25(OH)(2)D3), its two binding proteins that are the vitamin D receptor (VDR) and the vitamin D-binding protein-derived macrophage activating factor (GcMAF). Vitamin D 108-117 vitamin D receptor Homo sapiens 293-296 23857228-5 2013 This allows 1,25(OH)(2)D3 and oleic acid to become sandwiched between the two vitamin D-binding proteins, thus postulating a novel molecular mode of interaction between GcMAF and VDR. Vitamin D 78-87 vitamin D receptor Homo sapiens 179-182 23877860-3 2013 PATIENTS AND METHODS: We studied in a cohort of 91 HIV-infected Italian patients the metabolism of Vitamin D by evaluating the in vitro expression of CYP27B1, CYP24A1 and vitamin D receptor (VDR) by monocytes and macrophages stimulated with the viral envelope protein gp120 or lipopolysaccharide (LPS). Vitamin D 99-108 vitamin D receptor Homo sapiens 191-194 23416104-6 2013 In this research, we demonstrated that some novel vitamin D derivatives (12-MP, 13-MP, 15-MP and 16-LP) have strong transactivation activities in spite of lower affinity for VDR than 1. Vitamin D 50-59 vitamin D receptor Homo sapiens 174-177 23059472-0 2013 Vitamin D less-calcemic analog modulates the expression of estrogen receptors, vitamin D receptor and 1alpha-hydroxylase 25-hydroxy vitamin D in human thyroid cancer cell lines. Vitamin D 0-9 vitamin D receptor Homo sapiens 79-97 23059472-10 2013 This is the first report to describe direct regulation of VDR and 1OHase expression by a vitamin D analog in human thyroid cancer cells. Vitamin D 89-98 vitamin D receptor Homo sapiens 58-61 23401126-2 2013 The ligand-bound vitamin D receptor (VDR), heterodimerized with retinoid X receptor, interacts with vitamin D response elements (VDREs) to regulate gene expression. Vitamin D 17-26 vitamin D receptor Homo sapiens 37-40 23401126-4 2013 OBJECTIVE: To study a protective role of vitamin D in multiple sclerosis (MS), it is important to characterize the global molecular network of VDR target genes (VDRTGs) in immune cells. Vitamin D 41-50 vitamin D receptor Homo sapiens 143-146 23453529-1 2013 BACKGROUND: Vitamin D regulates many biological processes including bone metabolism, innate immune response, and cell proliferation and differentiation by binding to its receptor VDR. Vitamin D 12-21 vitamin D receptor Homo sapiens 179-182 23785369-1 2013 The vitamin D receptor (VDR) is a nuclear, ligand-dependent transcription factor that in complex with hormonally active vitamin D, 1,25(OH)2D3, regulates the expression of more than 900 genes involved in a wide array of physiological functions. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 23246987-1 2013 Recently, we evaluated a novel skeleton in the vitamin D family, 14-epi-1alpha,25(OH)2-19-nortachysterol, and discovered its unique binding configuration in the human vitamin D receptor (VDR) with the C5,6- and C7,8-s-trans triene configuration. Vitamin D 47-56 vitamin D receptor Homo sapiens 167-185 23246987-1 2013 Recently, we evaluated a novel skeleton in the vitamin D family, 14-epi-1alpha,25(OH)2-19-nortachysterol, and discovered its unique binding configuration in the human vitamin D receptor (VDR) with the C5,6- and C7,8-s-trans triene configuration. Vitamin D 47-56 vitamin D receptor Homo sapiens 187-190 23657931-6 2013 Poor vitamin D status affects muscle strength, and vitamin D may participate in protein synthesis through the actions of the vitamin D receptor in muscle tissue. Vitamin D 51-60 vitamin D receptor Homo sapiens 125-143 23142286-2 2013 The active form of vitamin D, 1,25-dihydroxycholecalciferol (1,25(OH)2 D3) is a natural ligand for vitamin D receptor (VDR). Vitamin D 19-28 vitamin D receptor Homo sapiens 99-117 23142286-2 2013 The active form of vitamin D, 1,25-dihydroxycholecalciferol (1,25(OH)2 D3) is a natural ligand for vitamin D receptor (VDR). Vitamin D 19-28 vitamin D receptor Homo sapiens 119-122 23142286-5 2013 The mechanism of vitamin D action is mediated by the nuclear VDR and the signaling cascade for its action is extensively reported. Vitamin D 17-26 vitamin D receptor Homo sapiens 61-64 23142286-7 2013 These include (1) differential effects of vitamin D in maintaining cell proliferation when the cells are under stress but suppressing cell growth when the cells are transformed; (2) functional significance of VDR polymorphism in potential vitamin D responsiveness; (3) regulation of constitutive splicing of vitamin D target gene, CYP24a, by the hormone and its significance; and (4) regulation of microRNA by vitamin D in breast cancer. Vitamin D 239-248 vitamin D receptor Homo sapiens 209-212 23142286-7 2013 These include (1) differential effects of vitamin D in maintaining cell proliferation when the cells are under stress but suppressing cell growth when the cells are transformed; (2) functional significance of VDR polymorphism in potential vitamin D responsiveness; (3) regulation of constitutive splicing of vitamin D target gene, CYP24a, by the hormone and its significance; and (4) regulation of microRNA by vitamin D in breast cancer. Vitamin D 239-248 vitamin D receptor Homo sapiens 209-212 23142286-7 2013 These include (1) differential effects of vitamin D in maintaining cell proliferation when the cells are under stress but suppressing cell growth when the cells are transformed; (2) functional significance of VDR polymorphism in potential vitamin D responsiveness; (3) regulation of constitutive splicing of vitamin D target gene, CYP24a, by the hormone and its significance; and (4) regulation of microRNA by vitamin D in breast cancer. Vitamin D 239-248 vitamin D receptor Homo sapiens 209-212 23826116-1 2013 The vitamin D receptor (VDR) principally mediates the anticancer activities of vitamin D. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 23805323-4 2013 We hypothesized that VDR expression, VDR level and transactivation of target genes, CAMP and CYP24A1, depend on vitamin D, ethnicity and FokI genotype. Vitamin D 112-121 vitamin D receptor Homo sapiens 21-24 23362149-1 2013 When bound to the vitamin D receptor (VDR), the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is a potent regulator of osteoblast transcription. Vitamin D 18-27 vitamin D receptor Homo sapiens 38-41 23169318-3 2013 We systemically evaluated the association of 89 tagging and candidate-based GSVs in six major vitamin D metabolism pathway genes (VDR, GC, CYP24A1, CYP27A1, CYP27B1 and CYP2R1) and the circulating serum vitamin D level with overall survival (OS) and second primary cancer (SPC) in 522 Stages I-II radiation-treated patients with HNC. Vitamin D 94-103 vitamin D receptor Homo sapiens 130-133 23971693-6 2013 Preclinical studies from our laboratory have identified that vitamin D deficiency exacerbates proteinuria and hypertension in experimental PKD, and that this is reversed by treatment with vitamin D receptor agonist. Vitamin D 61-70 vitamin D receptor Homo sapiens 188-206 23682710-2 2013 The possibility of extraskeletal effects of vitamin D was first noted with the discovery of the vitamin D receptor (VDR) in tissues and cells that are not involved in maintaining mineral homeostasis and bone health, including skin, placenta, pancreas, breast, prostate and colon cancer cells, and activated T cells. Vitamin D 44-53 vitamin D receptor Homo sapiens 96-114 23682710-2 2013 The possibility of extraskeletal effects of vitamin D was first noted with the discovery of the vitamin D receptor (VDR) in tissues and cells that are not involved in maintaining mineral homeostasis and bone health, including skin, placenta, pancreas, breast, prostate and colon cancer cells, and activated T cells. Vitamin D 44-53 vitamin D receptor Homo sapiens 116-119 23690102-3 2013 Vitamin D exerts its effect through vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 36-54 23690102-3 2013 Vitamin D exerts its effect through vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 56-59 23160722-0 2013 Vitamin D Receptor Fok-I polymorphism modulates diabetic host response to vitamin D intake: need for a nutrigenetic approach. Vitamin D 74-83 vitamin D receptor Homo sapiens 0-18 23352876-1 2013 AIM: Vitamin D deficiency is associated with coronary artery disease (CAD), and the actions of vitamin D are mediated by binding to a specific nuclear vitamin D receptor (VDR). Vitamin D 5-14 vitamin D receptor Homo sapiens 151-169 23352876-1 2013 AIM: Vitamin D deficiency is associated with coronary artery disease (CAD), and the actions of vitamin D are mediated by binding to a specific nuclear vitamin D receptor (VDR). Vitamin D 5-14 vitamin D receptor Homo sapiens 171-174 23352876-1 2013 AIM: Vitamin D deficiency is associated with coronary artery disease (CAD), and the actions of vitamin D are mediated by binding to a specific nuclear vitamin D receptor (VDR). Vitamin D 95-104 vitamin D receptor Homo sapiens 151-169 23352876-1 2013 AIM: Vitamin D deficiency is associated with coronary artery disease (CAD), and the actions of vitamin D are mediated by binding to a specific nuclear vitamin D receptor (VDR). Vitamin D 95-104 vitamin D receptor Homo sapiens 171-174 23703334-2 2013 Regulation of bone and mineral metabolism is a classic vitamin D effect, but the identification of the vitamin D receptor (VDR) in almost all human cells suggests a role for vitamin D also in extra-skeletal diseases. Vitamin D 103-112 vitamin D receptor Homo sapiens 123-126 23300018-1 2013 Several studies have suggested that the anticancerogenous effects of vitamin D might be modulated by genetic variants in the vitamin D receptor (VDR) gene. Vitamin D 69-78 vitamin D receptor Homo sapiens 125-143 23300018-1 2013 Several studies have suggested that the anticancerogenous effects of vitamin D might be modulated by genetic variants in the vitamin D receptor (VDR) gene. Vitamin D 69-78 vitamin D receptor Homo sapiens 145-148 23311753-3 2013 We hypothesised that bortezomib could influence osteoblastic differentiation via alteration of vitamin D signalling by blocking the proteasomal degradation of the vitamin D receptor (VDR). Vitamin D 95-104 vitamin D receptor Homo sapiens 163-181 23311753-3 2013 We hypothesised that bortezomib could influence osteoblastic differentiation via alteration of vitamin D signalling by blocking the proteasomal degradation of the vitamin D receptor (VDR). Vitamin D 95-104 vitamin D receptor Homo sapiens 183-186 23160722-11 2013 CONCLUSIONS: We concluded that those of VDR ff genotype may be regarded as "low responders" to vitamin D intake in terms of response of circulating 25(OH)D and certain inflammatory biomarkers. Vitamin D 95-104 vitamin D receptor Homo sapiens 40-43 23114382-6 2013 Recent advances in the methodology of large-scale genetic association studies, including coordinated international collaboration, have identified associations of CG, DHCR1, CYP2R1, VDR, and CYP24A1 with serum levels of vitamin D. Vitamin D 219-228 vitamin D receptor Homo sapiens 181-184 23266184-1 2013 From our research of nonsecosteroidal vitamin D(3) derivatives with gamma hydroxy carboxylic acid, we identified compound 6, with two CF(3) groups in the side chain, as a most potent vitamin D receptor (VDR) agonist that shows superagonistic activity in VDRE reporter gene assay, MG-63 osteocalcin production assay and HL-60 cell differentiation assay. Vitamin D 38-47 vitamin D receptor Homo sapiens 183-201 23266184-1 2013 From our research of nonsecosteroidal vitamin D(3) derivatives with gamma hydroxy carboxylic acid, we identified compound 6, with two CF(3) groups in the side chain, as a most potent vitamin D receptor (VDR) agonist that shows superagonistic activity in VDRE reporter gene assay, MG-63 osteocalcin production assay and HL-60 cell differentiation assay. Vitamin D 38-47 vitamin D receptor Homo sapiens 203-206 23277283-2 2013 The effects of vitamin D are mediated via the vitamin D receptor (VDR) which is encoded by VDR gene. Vitamin D 15-24 vitamin D receptor Homo sapiens 46-64 23277283-2 2013 The effects of vitamin D are mediated via the vitamin D receptor (VDR) which is encoded by VDR gene. Vitamin D 15-24 vitamin D receptor Homo sapiens 66-69 23277283-2 2013 The effects of vitamin D are mediated via the vitamin D receptor (VDR) which is encoded by VDR gene. Vitamin D 15-24 vitamin D receptor Homo sapiens 91-94 23020803-5 2013 Since then, the findings that vitamin D receptors (VDR) are present in many body tissues and that vitamin D metabolizing enzymes can be found in various cells outside the kidney, including the intestine, prostate, immune cells, and within the skin itself (reviewed in reference 3), have revolutionized the vitamin D business. Vitamin D 30-39 vitamin D receptor Homo sapiens 51-54 23393347-2 2013 The enzyme 25-hydroxyvitamin D 24-hydroxylase (CYP24A1), which degrades the active form of vitamin D, and the vitamin D receptor (VDR) are both found in breast tissue. Vitamin D 21-30 vitamin D receptor Homo sapiens 110-128 23393347-2 2013 The enzyme 25-hydroxyvitamin D 24-hydroxylase (CYP24A1), which degrades the active form of vitamin D, and the vitamin D receptor (VDR) are both found in breast tissue. Vitamin D 21-30 vitamin D receptor Homo sapiens 130-133 22782502-1 2013 The hormonal metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D(3) (1,25D), initiates biological responses via binding to the vitamin D receptor (VDR). Vitamin D 27-36 vitamin D receptor Homo sapiens 129-147 22782502-1 2013 The hormonal metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D(3) (1,25D), initiates biological responses via binding to the vitamin D receptor (VDR). Vitamin D 27-36 vitamin D receptor Homo sapiens 149-152 22782502-2 2013 When occupied by 1,25D, VDR interacts with the retinoid X receptor (RXR) to form a heterodimer that binds to vitamin D responsive elements in the region of genes directly controlled by 1,25D. Vitamin D 109-118 vitamin D receptor Homo sapiens 24-27 22782502-3 2013 By recruiting complexes of either coactivators or corepressors, ligand-activated VDR-RXR modulates the transcription of genes encoding proteins that promulgate the traditional functions of vitamin D, including signaling intestinal calcium and phosphate absorption to effect skeletal and calcium homeostasis. Vitamin D 189-198 vitamin D receptor Homo sapiens 81-84 22782502-6 2013 Finally, alternative, low-affinity, non-vitamin D VDR ligands, e.g., lithocholic acid, docosahexaenoic acid, and curcumin, have been reported. Vitamin D 40-49 vitamin D receptor Homo sapiens 50-53 23070913-1 2013 Polymorphism of genes encoding components of the vitamin D pathway including vitamin D receptor (VDR) and vitamin D binding protein (VDBP), have been widely explored due to the complex role played by vitamin D in renal transplant outcomes. Vitamin D 49-58 vitamin D receptor Homo sapiens 77-95 23200756-2 2013 Polymorphisms in the VDR gene may alter the actions of vitamin D and then influence the development and the severity of asthma. Vitamin D 55-64 vitamin D receptor Homo sapiens 21-24 23200756-3 2013 AIMS: We aimed at elucidating the genetic association of VDR gene polymorphisms with susceptibility to asthma in Tunisian children and with serum vitamin D levels. Vitamin D 146-155 vitamin D receptor Homo sapiens 57-60 22763025-2 2013 Vitamin D receptor occurs in different tissues, and several cells other than renal cells are able to locally produce active vitamin D, which is responsible for transcriptional control of hundreds of genes related to its pleiotropic effects. Vitamin D 124-133 vitamin D receptor Homo sapiens 0-18 23334593-7 2013 In primary human astrocytes in vitro, the active form of vitamin D, 1,25(OH)(2)D(3), induced upregulation of VDR and CYP24A1. Vitamin D 57-66 vitamin D receptor Homo sapiens 109-112 23334593-9 2013 Increased VDR expression in MS NAWM and inflammatory cytokine-induced amplified expression of VDR and CYP27B1 in chronic active MS lesions suggest increased sensitivity to vitamin D in NAWM and a possible endogenous role for vitamin D metabolism in the suppression of active MS lesions. Vitamin D 172-181 vitamin D receptor Homo sapiens 10-13 23334593-9 2013 Increased VDR expression in MS NAWM and inflammatory cytokine-induced amplified expression of VDR and CYP27B1 in chronic active MS lesions suggest increased sensitivity to vitamin D in NAWM and a possible endogenous role for vitamin D metabolism in the suppression of active MS lesions. Vitamin D 172-181 vitamin D receptor Homo sapiens 94-97 23070913-1 2013 Polymorphism of genes encoding components of the vitamin D pathway including vitamin D receptor (VDR) and vitamin D binding protein (VDBP), have been widely explored due to the complex role played by vitamin D in renal transplant outcomes. Vitamin D 49-58 vitamin D receptor Homo sapiens 97-100 23070913-1 2013 Polymorphism of genes encoding components of the vitamin D pathway including vitamin D receptor (VDR) and vitamin D binding protein (VDBP), have been widely explored due to the complex role played by vitamin D in renal transplant outcomes. Vitamin D 77-86 vitamin D receptor Homo sapiens 97-100 23178257-4 2013 Thus, vitamin D signaling primarily implies the molecular actions of the VDR. Vitamin D 6-15 vitamin D receptor Homo sapiens 73-76 23178257-6 2013 By comparing the actions of the VDR, a relatively well-understood and characterized protein, with those of other transcription factors, we aim to build a realistic positioning of vitamin D signaling in the context of other intracellular signaling systems. Vitamin D 179-188 vitamin D receptor Homo sapiens 32-35 24617042-12 2013 In conclusion, 84.8% of children with type-1 DM have low circulating levels of 25(OH) D. These patients have poor glycemic control (56.06%) than those with sufficient levels of 25(OH) D. Fokl polymorphism of VDR gene is associated with vitamin D deficiency but has no significant role in susceptibility to type-1 diabetes. Vitamin D 236-245 vitamin D receptor Homo sapiens 208-211 23724632-0 2013 Vitamin D status in female students and its relation to calcium metabolism markers, lifestyles, and polymorphism in vitamin D receptor. Vitamin D 0-9 vitamin D receptor Homo sapiens 116-134 23724632-3 2013 The aim of this study was to evaluate the prevalence of vitamin D deficiency and its relation with vitamin D receptor (VDR) gene polymorphism. Vitamin D 56-65 vitamin D receptor Homo sapiens 99-117 23724632-3 2013 The aim of this study was to evaluate the prevalence of vitamin D deficiency and its relation with vitamin D receptor (VDR) gene polymorphism. Vitamin D 56-65 vitamin D receptor Homo sapiens 119-122 23879537-5 2013 The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D) functions as a steroid hormone that, when bound to its nuclear vitamin D receptor, is able to regulate target gene expression. Vitamin D 19-28 vitamin D receptor Homo sapiens 130-148 24494038-5 2013 Main products of CYP11A1-mediated metabolism on vitamin D are non-calcemic and non-toxic at relatively high doses and serve as partial agonists on the vitamin D receptor. Vitamin D 48-57 vitamin D receptor Homo sapiens 151-169 23392891-3 2013 In this study, we test the hypothesis that the TauT gene is regulated by vitamin D(3) (VD(3)) and retinoic acid (RA) via activation of the vitamin D receptor (VDR) and retinoic acid receptor (RXR). Vitamin D 73-82 vitamin D receptor Homo sapiens 139-157 23392891-3 2013 In this study, we test the hypothesis that the TauT gene is regulated by vitamin D(3) (VD(3)) and retinoic acid (RA) via activation of the vitamin D receptor (VDR) and retinoic acid receptor (RXR). Vitamin D 73-82 vitamin D receptor Homo sapiens 159-162 23094920-5 2013 Analytic epidemiologic studies of vitamin D and prostate cancer have focused on polymorphisms in the vitamin D receptor (VDR), on serum vitamin D levels, and on solar exposure. Vitamin D 34-43 vitamin D receptor Homo sapiens 101-119 23094920-5 2013 Analytic epidemiologic studies of vitamin D and prostate cancer have focused on polymorphisms in the vitamin D receptor (VDR), on serum vitamin D levels, and on solar exposure. Vitamin D 34-43 vitamin D receptor Homo sapiens 121-124 23094920-5 2013 Analytic epidemiologic studies of vitamin D and prostate cancer have focused on polymorphisms in the vitamin D receptor (VDR), on serum vitamin D levels, and on solar exposure. Vitamin D 101-110 vitamin D receptor Homo sapiens 121-124 23624519-0 2013 A new mechanism for amyloid-beta induction of iNOS: vitamin D-VDR pathway disruption. Vitamin D 52-61 vitamin D receptor Homo sapiens 62-65 23624519-5 2013 Our silencing experiments suggest that vitamin D regulates iNOS via VDR, not 1,25-MARRS, in cortical neurons. Vitamin D 39-48 vitamin D receptor Homo sapiens 68-71 23624519-7 2013 While our previous work demonstrates that Abeta pathology includes VDR suppression, our present work demonstrates that Abeta induces iNOS and that this effect is mediated via disruption of the vitamin D-VDR pathway. Vitamin D 193-202 vitamin D receptor Homo sapiens 203-206 24099173-7 2013 The effects of EB1089 on SGC-7901 SP cells were blocked by treating cells with vitamin D receceptor (VDR) siRNA or butin (an inhibitor of the mitochondrial apoptosis pathway). Vitamin D 79-88 vitamin D receptor Homo sapiens 101-104 22960018-9 2013 The interaction between VDR and PTPN2 polymorphisms in the risk of progression to T1D offers insight concerning the role of vitamin D in the etiology of T1D. Vitamin D 124-133 vitamin D receptor Homo sapiens 24-27 24081327-1 2013 BACKGROUND/AIMS: Vitamin D regulates gene transcription by binding to the vitamin D receptor (VDR), potentially affecting cardiometabolic disease risk. Vitamin D 17-26 vitamin D receptor Homo sapiens 74-92 24081327-1 2013 BACKGROUND/AIMS: Vitamin D regulates gene transcription by binding to the vitamin D receptor (VDR), potentially affecting cardiometabolic disease risk. Vitamin D 17-26 vitamin D receptor Homo sapiens 94-97 23690671-2 2013 Indeed, vitamin D and analogue molecules, besides the classical actions on bone metabolism, exert several beneficial effects on metabolic homeostasis, heart-cardiovascular, brain, and muscle physiological functions, throughout the interaction with the specific vitamin D receptor (VDR). Vitamin D 8-17 vitamin D receptor Homo sapiens 261-279 23690671-2 2013 Indeed, vitamin D and analogue molecules, besides the classical actions on bone metabolism, exert several beneficial effects on metabolic homeostasis, heart-cardiovascular, brain, and muscle physiological functions, throughout the interaction with the specific vitamin D receptor (VDR). Vitamin D 8-17 vitamin D receptor Homo sapiens 281-284 23554871-1 2013 BACKGROUND: Vitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 78-96 23554871-1 2013 BACKGROUND: Vitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 98-101 23544077-4 2013 Since vitamin D performs its function by binding the receptor encoded by the vitamin D-receptor gene (VDR), most studies have focused on polymorphisms (SNPs) within this gene. Vitamin D 6-15 vitamin D receptor Homo sapiens 77-95 24455835-6 2013 Disturbances of vitamin D target pathway can be genetically conditioned, hence the aim of this paper is to describe the distribution of polymorphic variants of vitamin D-binding protein gene (VDBP), vitamin D receptor gene (VDR) and gene of the calcium-sensing receptor (CaSR) with respect to PTH concentrations in serum and response to cinacalcet treatment in patients with secondary hyperparathyroidism in view of the differences in demographical, clinical and laboratory data of the dialysed patients. Vitamin D 16-25 vitamin D receptor Homo sapiens 199-217 23544077-4 2013 Since vitamin D performs its function by binding the receptor encoded by the vitamin D-receptor gene (VDR), most studies have focused on polymorphisms (SNPs) within this gene. Vitamin D 6-15 vitamin D receptor Homo sapiens 102-105 24455835-6 2013 Disturbances of vitamin D target pathway can be genetically conditioned, hence the aim of this paper is to describe the distribution of polymorphic variants of vitamin D-binding protein gene (VDBP), vitamin D receptor gene (VDR) and gene of the calcium-sensing receptor (CaSR) with respect to PTH concentrations in serum and response to cinacalcet treatment in patients with secondary hyperparathyroidism in view of the differences in demographical, clinical and laboratory data of the dialysed patients. Vitamin D 16-25 vitamin D receptor Homo sapiens 224-227 22610818-7 2012 Herein we demonstrate that although the vitamin D receptor (VDR) is present in both IBC and non-IBC cell lines, the effect of vitamin D treatment is significant only on the IBC cells. Vitamin D 40-49 vitamin D receptor Homo sapiens 60-63 24358453-4 2013 In particular, we note an interesting link between vitamin D/VDR signaling and tissue barriers. Vitamin D 51-60 vitamin D receptor Homo sapiens 61-64 23206285-2 2012 The active form of vitamin D, 1alpha,25(OH(2) )D(3) , targets the wnt/beta-catenin pathway by upregulating key tumor suppressor genes such as E-cadherin, which promotes an epithelial phenotype, but this is only possible when the vitamin D receptor (VDR) is present. Vitamin D 19-28 vitamin D receptor Homo sapiens 229-247 23206285-2 2012 The active form of vitamin D, 1alpha,25(OH(2) )D(3) , targets the wnt/beta-catenin pathway by upregulating key tumor suppressor genes such as E-cadherin, which promotes an epithelial phenotype, but this is only possible when the vitamin D receptor (VDR) is present. Vitamin D 19-28 vitamin D receptor Homo sapiens 249-252 22903070-1 2012 Experimental studies on the molecular regulation of human drug metabolism have revealed that vitamin D up-regulates transcription of several key enzymes, such as CYP3A4, through the vitamin D receptor pathway in intestinal and hepatic cells. Vitamin D 93-102 vitamin D receptor Homo sapiens 182-200