PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30287151-5 2019 Mechanistic studies reveal that pathways relevant to inflammation participate in the pathogenesis of DN, however, consumption of vitamin D-related products negatively regulates inflammatory response at multiple levels, indicated by inhibiting macrophage infiltration, nuclear factor-kappa B (NF-kappaB) activation, and production of such inflammatory mediators as transforming growth factor-beta(TGF-beta), monocyte chemoattractant protein 1(MCP-1), and regulated upon activation normal T cell expressed and secreted protein(RANTES). Vitamin D 129-138 C-C motif chemokine ligand 2 Homo sapiens 407-441 33107041-12 2021 Therefore, the mRNA levels of MCP-1 and IL-8 in hPDLCs were significantly decreased through the vitamin D pathway. Vitamin D 96-105 C-C motif chemokine ligand 2 Homo sapiens 30-35 31924826-9 2020 Supplementation of 25-vitamin D was able to reduce the expression of TRL4, cathelicidin, and MCP-1 in the uremic environment. Vitamin D 19-31 C-C motif chemokine ligand 2 Homo sapiens 93-98 33596158-0 2021 l-Cysteine Stimulates the Effect of Vitamin D on Inhibition of Oxidative Stress, IL-8, and MCP-1 Secretion in High Glucose Treated Monocytes. Vitamin D 36-45 C-C motif chemokine ligand 2 Homo sapiens 91-96 33596158-3 2021 This study examined the hypothesis that supplementation with vitamin D, in combination with l-cysteine (LC), is better at reducing oxidative stress and thereby, more effective, at inhibiting the secretion of the pro-inflammatory cytokines, Interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in U937 monocytes exposed to high glucose concentrations. Vitamin D 61-70 C-C motif chemokine ligand 2 Homo sapiens 265-299 33596158-3 2021 This study examined the hypothesis that supplementation with vitamin D, in combination with l-cysteine (LC), is better at reducing oxidative stress and thereby, more effective, at inhibiting the secretion of the pro-inflammatory cytokines, Interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in U937 monocytes exposed to high glucose concentrations. Vitamin D 61-70 C-C motif chemokine ligand 2 Homo sapiens 301-306 30287151-5 2019 Mechanistic studies reveal that pathways relevant to inflammation participate in the pathogenesis of DN, however, consumption of vitamin D-related products negatively regulates inflammatory response at multiple levels, indicated by inhibiting macrophage infiltration, nuclear factor-kappa B (NF-kappaB) activation, and production of such inflammatory mediators as transforming growth factor-beta(TGF-beta), monocyte chemoattractant protein 1(MCP-1), and regulated upon activation normal T cell expressed and secreted protein(RANTES). Vitamin D 129-138 C-C motif chemokine ligand 2 Homo sapiens 442-447 29520786-9 2018 IL-8 and monocyte chemotactic protein-1 mRNA expression could be suppressed by the vitamin D pathway. Vitamin D 83-92 C-C motif chemokine ligand 2 Homo sapiens 9-39 31425951-0 2019 Effects of vitamin D supplementation on circulatory YKL-40 and MCP-1 biomarkers associated with vascular diabetic complications: A randomized, placebo-controlled, double-blind clinical trial. Vitamin D 11-20 C-C motif chemokine ligand 2 Homo sapiens 63-68 31425951-5 2019 Therefore, this study was designed to investigate effects of vitamin D supplementation on serum levels of YKL-40 and MCP-1 involved in the development of diabetic complications. Vitamin D 61-70 C-C motif chemokine ligand 2 Homo sapiens 117-122 31425951-12 2019 CONCLUSIONS: Daily vitamin D supplementation effectively reduced circulatory YKL-40 and MCP-1 levels in patients with type-2 diabetes and vitamin D deficiency. Vitamin D 19-28 C-C motif chemokine ligand 2 Homo sapiens 88-93 31425951-12 2019 CONCLUSIONS: Daily vitamin D supplementation effectively reduced circulatory YKL-40 and MCP-1 levels in patients with type-2 diabetes and vitamin D deficiency. Vitamin D 138-147 C-C motif chemokine ligand 2 Homo sapiens 88-93 31425951-13 2019 Vitamin D might contribute in reducing diabetic complications via modulating YKL-40 and MCP-1 signaling pathways. Vitamin D 0-9 C-C motif chemokine ligand 2 Homo sapiens 88-93 30246883-7 2019 RESULTS: Vitamin D supplementation resulted in significant increase of serum 25OHD level (P < 0.001), and significant decrease in PTH (P < 0.001), MCP-1 (P < 0.05), IL-1beta (P < 0.05) and TLR-4 (P < 0.05); compared to the baseline values in vitamin D group. Vitamin D 9-18 C-C motif chemokine ligand 2 Homo sapiens 147-152 30246883-10 2019 CONCLUSIONS: Improvement in vitamin D status in obese subjects with vitamin D deficiency in combination with weight loss diet resulted in weight, fat mass and MCP-1 decrease. Vitamin D 28-37 C-C motif chemokine ligand 2 Homo sapiens 159-164 30246883-10 2019 CONCLUSIONS: Improvement in vitamin D status in obese subjects with vitamin D deficiency in combination with weight loss diet resulted in weight, fat mass and MCP-1 decrease. Vitamin D 68-77 C-C motif chemokine ligand 2 Homo sapiens 159-164 30362842-9 2018 At 15 ng/mL cut-off value, vitamin D was negatively correlated with MCP-1 (p = .0006). Vitamin D 27-36 C-C motif chemokine ligand 2 Homo sapiens 68-73 28765037-0 2018 Vitamin D effects on monocytes" CCL-2, IL6 and CD14 transcription in Addison"s disease and HLA susceptibility. Vitamin D 0-9 C-C motif chemokine ligand 2 Homo sapiens 32-37 28765037-8 2018 We found a downregulation of CCL-2 after vitamin D treatment in IL1beta-stimulated monocytes both from AD patients and HC (AD p<0.001; HC p<0.0001). Vitamin D 41-50 C-C motif chemokine ligand 2 Homo sapiens 29-34 30362842-11 2018 MCP-1 was a risk factor for vitamin D deficiency (p < .0001). Vitamin D 28-37 C-C motif chemokine ligand 2 Homo sapiens 0-5 23770363-0 2013 Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes. Vitamin D 0-9 C-C motif chemokine ligand 2 Homo sapiens 116-121 24007780-5 2013 Following vitamin D loading at 3 months, the relationships between some of the cytokines changed (TNF-alpha and MCP-1: r=0.38, p=0.017, IL-1beta and IL-17: r=0.3, p=0.06). Vitamin D 10-19 C-C motif chemokine ligand 2 Homo sapiens 112-117 24184699-4 2014 In this study we analyzed the role of 1,25(OH)2D3, the bioactive vitamin D metabolite, in the regulation of CCL2 expression by dendritic cells (DC) obtained from healthy donors and relapsing-remitting MS patients. Vitamin D 65-74 C-C motif chemokine ligand 2 Homo sapiens 108-112 24184871-5 2014 Adding 25(OH)D3 to monocytes cultured in vitamin D-deficient serum or media decreased monocyte adhesion to fibronectin and migration stimulated by monocyte chemotactic protein 1 (MCP-1). Vitamin D 41-50 C-C motif chemokine ligand 2 Homo sapiens 147-177 24184871-5 2014 Adding 25(OH)D3 to monocytes cultured in vitamin D-deficient serum or media decreased monocyte adhesion to fibronectin and migration stimulated by monocyte chemotactic protein 1 (MCP-1). Vitamin D 41-50 C-C motif chemokine ligand 2 Homo sapiens 179-184 23361158-11 2013 In vitro results confirm an MCP-1-lowering effect of vitamin D. Vitamin D 53-62 C-C motif chemokine ligand 2 Homo sapiens 28-33 23012315-4 2013 In the presence of LPS, vitamin D caused dose-dependent decreases in the messenger RNA expression of MCP-1, IL-1beta, IL-13, TNF-alpha, TLR-4, and TLR-5, the contractile-associated proteins connexin 43, the oxytocin receptor, and the prostaglandin receptor but caused increases in IL-10 and TLR-10 in UtSM cells. Vitamin D 24-33 C-C motif chemokine ligand 2 Homo sapiens 101-106 23012315-6 2013 Vitamin D also attenuated IL-1beta-induced MCP-1, IL-6, connexin 43, cyclooxygenase (COX)-2, and prostaglandin receptor expression. Vitamin D 0-9 C-C motif chemokine ligand 2 Homo sapiens 43-48 23012315-7 2013 Western analysis showed that vitamin D decreased MCP-1, TLR-4, and connexin 43 in the presence of LPS and decreased connexin 43 in the presence of IL-1beta. Vitamin D 29-38 C-C motif chemokine ligand 2 Homo sapiens 49-54 23361158-12 2013 Future studies should determine if vitamin D-mediated reductions in MCP-1 concentrations reflect improved clinical outcomes. Vitamin D 35-44 C-C motif chemokine ligand 2 Homo sapiens 68-73 35498406-0 2022 Vitamin D Reduces Thyroid Cancer Cells Migration Independently From the Modulation of CCL2 and CXCL8 Chemokines Secretion. Vitamin D 0-9 C-C motif chemokine ligand 2 Homo sapiens 86-90 22800603-5 2012 In HCs, vitamin D(3) significantly suppressed the MCP-1 mRNA expression of CFA stimulated cells (p=0.0027), while no such effect was observed in PTB patients. Vitamin D 8-17 C-C motif chemokine ligand 2 Homo sapiens 50-55 22993666-0 2012 Relationship between vitamin D and IL-23, IL-17 and macrophage chemoattractant protein-1 as markers of fibrosis in hepatitis C virus Egyptians. Vitamin D 21-30 C-C motif chemokine ligand 2 Homo sapiens 52-88 22993666-1 2012 AIM: To assess vitamin D in hepatitis C patients and its relationship to interleukin (IL)-23, IL-17, and macrophage chemoattractant protein-1 (MCP-1). Vitamin D 15-24 C-C motif chemokine ligand 2 Homo sapiens 105-141 22993666-1 2012 AIM: To assess vitamin D in hepatitis C patients and its relationship to interleukin (IL)-23, IL-17, and macrophage chemoattractant protein-1 (MCP-1). Vitamin D 15-24 C-C motif chemokine ligand 2 Homo sapiens 143-148 22993666-20 2012 IL-23, IL-17, and MCP-1 were markedly increased in HCV-infected patients in comparison to controls.A significant negative correlation between vitamin D and IL-17 and -23 and MCP-1 was detected. Vitamin D 142-151 C-C motif chemokine ligand 2 Homo sapiens 174-179 35403296-9 2022 After vitamin D supplementation for 90 days, T2DM patients had a 2-fold increase of GSH levels, from 2.72 +- 0.84 to 5.76 +- 3.19 mumol/ml, the concentration of MCP-1 decreased from 51.11 +- 20.86 to 25.42 +- 13.06 pg/ml, and IL-8 also decreased from 38.21 +- 21.76 to 16.05 +- 8.99 pg/ml. Vitamin D 6-15 C-C motif chemokine ligand 2 Homo sapiens 161-166 35403296-10 2022 In conclusion, our study demonstrated that vitamin D could regulate the production of GSH, thereby reducing the serum levels of MCP-1 and IL-8, alleviating oxidative stress and inflammation, providing evidence of the necessity and feasibility of adjuvant vitamin D treatment among patients with T2DM. Vitamin D 43-52 C-C motif chemokine ligand 2 Homo sapiens 128-133 22028071-10 2012 Both types of vitamin D contributed to a decrease in five out of seven markers of innate immunity, significantly more pronounced with HyD for eotaxin, IL-12, MCP-1, and MIP-1 beta. Vitamin D 14-23 C-C motif chemokine ligand 2 Homo sapiens 158-163 35498406-5 2022 The aim of the present study was to investigate if vitamin D could modulate both thyroid cancer cell migration and their ability to secrete CCL2 and CXCL8. Vitamin D 51-60 C-C motif chemokine ligand 2 Homo sapiens 140-144 35498406-9 2022 Vitamin D differently modulated the secretion of CCL2 and CXCL8, by significantly inhibiting the secretion of CCL2 in both thyroid cancer cell lines and inhibiting the secretion of CXCL8 only in TPC-1 (ANOVAs p < 0.05). Vitamin D 0-9 C-C motif chemokine ligand 2 Homo sapiens 49-53 35498406-9 2022 Vitamin D differently modulated the secretion of CCL2 and CXCL8, by significantly inhibiting the secretion of CCL2 in both thyroid cancer cell lines and inhibiting the secretion of CXCL8 only in TPC-1 (ANOVAs p < 0.05). Vitamin D 0-9 C-C motif chemokine ligand 2 Homo sapiens 110-114 35498406-11 2022 Future studies specifically designed at clarifying the pathways involved in the different inhibitory effects of vitamin D on CCL2 and CXCL8 in thyroid cancer cells appear worthwhile. Vitamin D 112-121 C-C motif chemokine ligand 2 Homo sapiens 125-129