PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33107041-13 2021 CONCLUSION: The vitamin D pathway from vitamin D3 to hCAP-18/LL-37 exists in hPDLCs, and CYP27A1 might be involved in periodontal immune defense. Vitamin D 16-25 cathelicidin antimicrobial peptide Homo sapiens 53-60 33107041-13 2021 CONCLUSION: The vitamin D pathway from vitamin D3 to hCAP-18/LL-37 exists in hPDLCs, and CYP27A1 might be involved in periodontal immune defense. Vitamin D 16-25 cathelicidin antimicrobial peptide Homo sapiens 61-66 32673820-6 2020 RESULTS: The hBD-2 and LL-37 levels were higher in periodontitis compared to gingivitis patients within Vitamin D sufficient and deficient groups. Vitamin D 104-113 cathelicidin antimicrobial peptide Homo sapiens 23-28 32867053-3 2020 Serum vitamin D concentration influences the expression of airway surface liquid (ASL) antimicrobial peptides such as LL-37. Vitamin D 6-15 cathelicidin antimicrobial peptide Homo sapiens 118-123 32867053-13 2020 Supplementation of vitamin D during winter-spring restores ASL antimicrobial activity by increasing the expression of antimicrobial peptides including LL-37. Vitamin D 19-28 cathelicidin antimicrobial peptide Homo sapiens 151-156 32671009-0 2020 Vitamin D Deficiency and Air Pollution Exacerbate COVID-19 Through Suppression of Antiviral Peptide LL37. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 100-104 32213352-2 2020 One mediator of vitamin D-dependent immune regulation and antimicrobial defense is the cathelicidin antimicrobial peptide (LL-37), encoded by the cathelicidin-related antimicrobial peptide (CRAMP) gene. Vitamin D 16-25 cathelicidin antimicrobial peptide Homo sapiens 87-121 32213352-2 2020 One mediator of vitamin D-dependent immune regulation and antimicrobial defense is the cathelicidin antimicrobial peptide (LL-37), encoded by the cathelicidin-related antimicrobial peptide (CRAMP) gene. Vitamin D 16-25 cathelicidin antimicrobial peptide Homo sapiens 123-128 32213352-2 2020 One mediator of vitamin D-dependent immune regulation and antimicrobial defense is the cathelicidin antimicrobial peptide (LL-37), encoded by the cathelicidin-related antimicrobial peptide (CRAMP) gene. Vitamin D 16-25 cathelicidin antimicrobial peptide Homo sapiens 146-188 32213352-2 2020 One mediator of vitamin D-dependent immune regulation and antimicrobial defense is the cathelicidin antimicrobial peptide (LL-37), encoded by the cathelicidin-related antimicrobial peptide (CRAMP) gene. Vitamin D 16-25 cathelicidin antimicrobial peptide Homo sapiens 190-195 32213352-8 2020 Increased VDR and decreased CRAMP expression are consistent with previously reported associations between vitamin D deficiency, immune dysregulation, and suicidal behavior, and should lead to future studies uncovering novel interactive targets for suicide prevention. Vitamin D 106-115 cathelicidin antimicrobial peptide Homo sapiens 28-33 32671009-7 2020 Vitamin D stimulates transcription of cathelicidin which is cleaved to generate LL37. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 80-84 32237947-0 2022 Intralesional Injection of Vitamin D in Verruca Vulgaris Increases Cathelicidin (LL37) Expression; Therapeutic and Immunohistochemical Study. Vitamin D 27-36 cathelicidin antimicrobial peptide Homo sapiens 81-85 32237947-1 2022 Introduction: Despite the promising results of intralesional vitamin D in verruca treatment; its precise mechanism of action is not fully understood.Aim of the work: To investigate immunohistochemical expression of cathelicidin (LL 37) before and after injection of vitamin D in verruca vulgaris and to clarify its possible role in pathogenesis of verruca.Patients and methods: This study included 20 patients with multiple verrucae vulgaris. Vitamin D 61-70 cathelicidin antimicrobial peptide Homo sapiens 229-234 32237947-5 2022 Significant increase in LL37 intensity of expression was observed after intralesional injection of vitamin D3 (p = 0.003) and in verrucae showing complete clinical response (p = 0.022).Conclusions: Intralesional injection of vitamin D is effective and safe treatment for verruca vulgaris and causes increase in LL37 expression. Vitamin D 99-108 cathelicidin antimicrobial peptide Homo sapiens 24-28 31783153-1 2020 In humans and other primates, 1,25(OH)2vitamin D3 regulates the expression of the cathelicidin antimicrobial peptide (CAMP) gene via toll-like receptor (TLR) signaling that activates the vitamin D pathway. Vitamin D 39-48 cathelicidin antimicrobial peptide Homo sapiens 82-116 31783153-1 2020 In humans and other primates, 1,25(OH)2vitamin D3 regulates the expression of the cathelicidin antimicrobial peptide (CAMP) gene via toll-like receptor (TLR) signaling that activates the vitamin D pathway. Vitamin D 39-48 cathelicidin antimicrobial peptide Homo sapiens 118-122 29338758-12 2018 Vitamin D status at 6 years of age was unrelated to enamel defects but was positively associated with saliva LL37 levels. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 109-113 31642155-5 2020 Vitamin D downstream signalling has also been checked in placenta (VDR, CYP27B1, Cathelicidin LL37) along with expression of inflammatory markers (S100A8, HMGB1, TLR2, pNF-kappaB) using Western blotting and immunohistochemistry. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 94-98 33092508-14 2020 While human LL-37 can be induced by vitamin D, vitamin A induces the expression of resistin-like molecule alpha (RELMalpha) in mice. Vitamin D 36-45 cathelicidin antimicrobial peptide Homo sapiens 12-17 31824492-3 2019 Vitamin D driven, Cathelicidin-type antimicrobial peptides (CAMP) play an important role in the elimination of invading microorganisms. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 18-58 31824492-3 2019 Vitamin D driven, Cathelicidin-type antimicrobial peptides (CAMP) play an important role in the elimination of invading microorganisms. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 60-64 31824492-6 2019 Activating the CAMP pathway using Vitamin D in hMDM1 resulted in a cathelicidin-mediated-Leishmania restriction. Vitamin D 34-43 cathelicidin antimicrobial peptide Homo sapiens 15-19 31245047-10 2019 In multivariable models, controlling for age, sex, SE, smoking and vitamin D deficiency, LL37 level (top quartile) associated with anti-CCP seropositivity (OR 22; 95% CI 4 to 104). Vitamin D 67-76 cathelicidin antimicrobial peptide Homo sapiens 89-93 30811465-1 2019 INTRODUCTION: Cathelicidin (also known as LL-37 in humans) is an antimicrobial peptide secreted by epithelial and immune cells and regulated by vitamin D. Vitamin D 144-153 cathelicidin antimicrobial peptide Homo sapiens 42-47 30216432-9 2019 In addition, simvastatin increased transcription of the vitamin D-activating enzyme CYP27B1 which, in turn, may activate LL-37/hCAP-18 production. Vitamin D 56-65 cathelicidin antimicrobial peptide Homo sapiens 121-126 30216432-9 2019 In addition, simvastatin increased transcription of the vitamin D-activating enzyme CYP27B1 which, in turn, may activate LL-37/hCAP-18 production. Vitamin D 56-65 cathelicidin antimicrobial peptide Homo sapiens 127-134 29520786-1 2018 BACKGROUND: The vitamin D pathway, from toll-like receptor activation to human cationic antimicrobial protein (hCAP-18/LL-37) generation, has been identified in monocytes and keratinocytes. Vitamin D 16-25 cathelicidin antimicrobial peptide Homo sapiens 111-118 29520786-1 2018 BACKGROUND: The vitamin D pathway, from toll-like receptor activation to human cationic antimicrobial protein (hCAP-18/LL-37) generation, has been identified in monocytes and keratinocytes. Vitamin D 16-25 cathelicidin antimicrobial peptide Homo sapiens 119-124 31330899-7 2019 Subgroup-analyses of vitamin D insufficient subjects demonstrated a significant increase of LL-37 in the treatment group (p = 0.02), whereas treatment failed to significantly impact LL-37-levels in multiple regression analysis. Vitamin D 21-30 cathelicidin antimicrobial peptide Homo sapiens 92-97 29338758-14 2018 Vitamin D status at 6 years of age was unrelated to enamel defects but was positively associated with LL37 expression. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 102-106 27357804-1 2016 The biologically active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25D3), has been reported to positively regulate the human cathelicidin anti-microbial peptide (CAMP) gene coding for LL-37, but the mechanisms are not completely understood. Vitamin D 32-41 cathelicidin antimicrobial peptide Homo sapiens 171-175 27663530-2 2017 The expression of LL-37 is controlled by various factors, including vitamin D. Vitamin D 68-77 cathelicidin antimicrobial peptide Homo sapiens 18-23 27663530-3 2017 Thus, any disturbances in vitamin D level may influence LL-37 production and, possibly, affect wound healing. Vitamin D 26-35 cathelicidin antimicrobial peptide Homo sapiens 56-61 27663530-4 2017 Since deficiency of vitamin D was identified as a common problem in the population, this proof of concept study aimed to verify the relationship between serum levels of LL-37, vitamin D, and healing rate of venous leg ulcers. Vitamin D 20-29 cathelicidin antimicrobial peptide Homo sapiens 169-174 28231019-1 2017 Vitamin D is a regulator of host defense against infections and induces expression of the antimicrobial peptide hCAP18/LL-37. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 112-118 28231019-8 2017 We found that TNF-alpha/IL-1beta treatment reduced vitamin D-induced expression of hCAP18/LL-37 and killing of nontypeable H. influenzae. Vitamin D 51-60 cathelicidin antimicrobial peptide Homo sapiens 83-89 27696351-10 2017 Vitamin D deficiency was most prevalent at Poundbury Camp (CPR 18.8%), vitamin C deficiency was identified more frequently in rural settlements (CPR 5.9%). Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 53-57 28111615-3 2016 Although data on the efficacy of vitamin D supplementation on Mycobacterium tuberculosis (Mtb) clearance is uncertain from randomized controlled trials (RCTs), vitamin D enhances the expression of the anti-microbial peptide human cathelicidin (hCAP18) in cultured macrophages in vitro. Vitamin D 160-169 cathelicidin antimicrobial peptide Homo sapiens 244-250 28662432-2 2017 Vitamin D-regulated cationic antimicrobial peptide cathelicidin (hCAP-18/LL-37) has microbicidal and immunomodulatory role against cutaneous infections, but its role in PKDL remains elusive. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 65-72 28662432-2 2017 Vitamin D-regulated cationic antimicrobial peptide cathelicidin (hCAP-18/LL-37) has microbicidal and immunomodulatory role against cutaneous infections, but its role in PKDL remains elusive. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 73-78 28012697-4 2017 The expression of LL-37 can be regulated by various endogenous factors including the active form of vitamin D (25(OH)D3). Vitamin D 100-109 cathelicidin antimicrobial peptide Homo sapiens 18-23 27357804-1 2016 The biologically active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25D3), has been reported to positively regulate the human cathelicidin anti-microbial peptide (CAMP) gene coding for LL-37, but the mechanisms are not completely understood. Vitamin D 32-41 cathelicidin antimicrobial peptide Homo sapiens 193-198 27488327-10 2016 The mean fold change in hCAP18 gene expression in Vitamin D group was significantly higher than placebo group. Vitamin D 50-59 cathelicidin antimicrobial peptide Homo sapiens 24-30 27795667-2 2016 In the pulmonary system, vitamin D regulates the function of antimicrobial peptides, especially cathelicidin/LL-37. Vitamin D 25-34 cathelicidin antimicrobial peptide Homo sapiens 109-114 27392908-1 2016 BACKGROUND: Vitamin D and vitamin D dependent antimicrobial peptides such as Cathelicidin (LL-37) and beta-defensin 2 have an important role in innate and adaptative immunity, but their role in pleural effusions has not been studied before. Vitamin D 12-21 cathelicidin antimicrobial peptide Homo sapiens 91-96 27392908-1 2016 BACKGROUND: Vitamin D and vitamin D dependent antimicrobial peptides such as Cathelicidin (LL-37) and beta-defensin 2 have an important role in innate and adaptative immunity, but their role in pleural effusions has not been studied before. Vitamin D 26-35 cathelicidin antimicrobial peptide Homo sapiens 91-96 27488327-12 2016 CONCLUSION: Decreases in ESR and hs-CRP levels and increase in LL37 gene expression support the hypothesis that Vitamin D supplementation may have a beneficial role in UC patients. Vitamin D 112-121 cathelicidin antimicrobial peptide Homo sapiens 63-67 26058412-8 2016 However, vitamin D could reverse the inhibition of both VDR and LL-37 [1.5-fold increase (P = 0.001) and 2000-fold increase (P < 0.001) respectively]. Vitamin D 9-18 cathelicidin antimicrobial peptide Homo sapiens 64-69 26304030-3 2016 CAMP gene expression is regulated by vitamin D-dependent (VDR) and vitamin D-independent (C/EBPalpha) transcription factors. Vitamin D 37-46 cathelicidin antimicrobial peptide Homo sapiens 0-4 26304030-5 2016 Historically, the Celts may have overcome this geographical disadvantage of deficient CAMP production during the winter through an as-yet undefined acquired mutation that activates the alternative vitamin D-independent CAMP promoter C/EBPalpha. Vitamin D 197-206 cathelicidin antimicrobial peptide Homo sapiens 86-90 26304030-5 2016 Historically, the Celts may have overcome this geographical disadvantage of deficient CAMP production during the winter through an as-yet undefined acquired mutation that activates the alternative vitamin D-independent CAMP promoter C/EBPalpha. Vitamin D 197-206 cathelicidin antimicrobial peptide Homo sapiens 219-223 26585423-0 2016 Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 80-85 26585423-4 2016 RV and LL-37 levels were measured in bronchoalveolar lavage (BAL) of CF children infected with RV.Vitamin D reduced RV16 load in a dose-dependent manner in CF cells (10(-7 )M, p<0.01). Vitamin D 98-107 cathelicidin antimicrobial peptide Homo sapiens 7-12 26585423-7 2016 Vitamin D increased the expression of the antimicrobial peptide LL-37 up to 17.4-fold (p<0.05). Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 64-69 26585423-9 2016 An inverse correlation between viral load and LL-37 levels in CF BAL (r=-0.48, p<0.05) was observed.RV replication in primary CF bronchial cells was reduced by vitamin D through the induction of LL-37. Vitamin D 163-172 cathelicidin antimicrobial peptide Homo sapiens 46-51 26585423-9 2016 An inverse correlation between viral load and LL-37 levels in CF BAL (r=-0.48, p<0.05) was observed.RV replication in primary CF bronchial cells was reduced by vitamin D through the induction of LL-37. Vitamin D 163-172 cathelicidin antimicrobial peptide Homo sapiens 198-203 26058412-0 2016 Enhanced LL-37 expression following vitamin D supplementation in patients with cirrhosis and spontaneous bacterial peritonitis. Vitamin D 36-45 cathelicidin antimicrobial peptide Homo sapiens 9-14 26058412-2 2016 This study aimed to determine the role of the vitamin D-LL-37 pathway in the pathogenesis and treatment in patients with cirrhosis and SBP. Vitamin D 46-55 cathelicidin antimicrobial peptide Homo sapiens 56-61 26058412-9 2016 The effect of the incubation time following vitamin D supplementation was significant for LL-37 expression, with a peak expression found at 36 h (P < 0.001). Vitamin D 44-53 cathelicidin antimicrobial peptide Homo sapiens 90-95 26058412-10 2016 CONCLUSIONS: When vitamin D levels were low, bacteria inhibited VDR and LL-37 responses in peritoneal macrophages as a mechanism to evade antibacterial defence. Vitamin D 18-27 cathelicidin antimicrobial peptide Homo sapiens 72-77 26058412-11 2016 Vitamin D supplementation could up-regulate peritoneal macrophage VDR and LL-37 expressions, which resulted in an enhanced immunological defence against SBP in patients with cirrhosis and ascites. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 74-79 25092518-9 2015 Expression of CAMP increased significantly from baseline after 52 weeks of vitamin D-supplementation. Vitamin D 75-84 cathelicidin antimicrobial peptide Homo sapiens 14-18 26375724-16 2015 However, LL-37 expression is vitamin D dependent, and inadequate serum levels (< 30 ng/mL) were present in 72% of those tested. Vitamin D 29-38 cathelicidin antimicrobial peptide Homo sapiens 9-14 26641549-8 2015 RESULTS: When treated with inactive vitamin D metabolites, HCEC produced active 1,25D3, leading to enhanced expression of the antimicrobial peptide, LL-37, dependent on VDR. Vitamin D 36-45 cathelicidin antimicrobial peptide Homo sapiens 149-154 26294193-2 2015 Vitamin D-mediated induction of the host defence peptide LL-37 is known to enhance control of pathogens such as Mycobacterium tuberculosis. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 57-62 25092518-10 2015 At this time point, TLR2/1L-induced CAMP was positively associated with percent change from baseline in 25OHD (p=0.029 overall and 0.002 within vitamin D-supplemented only). Vitamin D 144-153 cathelicidin antimicrobial peptide Homo sapiens 36-40 25078430-5 2015 A C/EBP binding site was identified at -627/-619 within the CAMP promoter, adjacent to the vitamin D response element (VDRE; -615/-600). Vitamin D 91-100 cathelicidin antimicrobial peptide Homo sapiens 60-64 25973241-6 2015 The objective of the present study was to explore the relationship between LL-37 plasma levels, vitamin D status and exacerbation risk in patients with COPD. Vitamin D 96-105 cathelicidin antimicrobial peptide Homo sapiens 75-80 25673925-0 2015 Vitamin D Status and Its Association with the SCORAD Score and Serum LL-37 Level in Korean Adults and Children with Atopic Dermatitis. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 69-74 25510482-0 2015 Pulmonary tuberculosis patients with a vitamin D deficiency demonstrate low local expression of the antimicrobial peptide LL-37 but enhanced FoxP3+ regulatory T cells and IgG-secreting cells. Vitamin D 39-48 cathelicidin antimicrobial peptide Homo sapiens 122-127 25510482-2 2015 We demonstrate that pulmonary TB patients with a vitamin D deficiency had significantly reduced local levels of the vitamin D-inducible antimicrobial peptide LL-37 in granulomatous lesions compared to distal parenchyma from the infected lung. Vitamin D 49-58 cathelicidin antimicrobial peptide Homo sapiens 158-163 25510482-2 2015 We demonstrate that pulmonary TB patients with a vitamin D deficiency had significantly reduced local levels of the vitamin D-inducible antimicrobial peptide LL-37 in granulomatous lesions compared to distal parenchyma from the infected lung. Vitamin D 116-125 cathelicidin antimicrobial peptide Homo sapiens 158-163 25089537-9 2014 However, stimulated intracellular LL-37 expression (ratio of stimulated:unstimulated MDM) was significantly reduced in the vitamin D group v. placebo (P=0 02). Vitamin D 123-132 cathelicidin antimicrobial peptide Homo sapiens 34-39 25549329-9 2014 Adjustment for PD cell CD14/CD45 expression using a mixed linear statistical model also revealed increased expression of CAMP (mRNA in PD cells and protein in effluent) in vitamin D-supplemented patients. Vitamin D 172-181 cathelicidin antimicrobial peptide Homo sapiens 121-125 26218841-1 2015 LL-37 is a human antimicrobial peptide (AMP) of the cathelicidin family with multiple activities including a mediator of vitamin D-induced autophagy in human macrophages, resulting in intracellular killing of Mycobacterium tuberculosis (Mtb). Vitamin D 121-130 cathelicidin antimicrobial peptide Homo sapiens 0-5 24798231-0 2014 LL-37 concentrations and the relationship to vitamin D, immune status, and inflammation in HIV-infected children and young adults. Vitamin D 45-54 cathelicidin antimicrobial peptide Homo sapiens 0-5 24798231-1 2014 Antimicrobial peptide LL-37 is produced in response to active vitamin D to exert immunomodulatory effects and inhibits HIV replication in vitro. Vitamin D 62-71 cathelicidin antimicrobial peptide Homo sapiens 22-27 24798231-11 2014 These findings suggest that HIV and/or HIV-related variables may alter the expected positive relationship between vitamin D and LL-37 and should be further investigated. Vitamin D 114-123 cathelicidin antimicrobial peptide Homo sapiens 128-133 24821067-0 2014 Plasma LL-37 correlates with vitamin D and is reduced in human immunodeficiency virus-1 infected individuals not receiving antiretroviral therapy. Vitamin D 29-38 cathelicidin antimicrobial peptide Homo sapiens 7-12 24821067-1 2014 Low levels of the vitamin D-regulated antimicrobial peptide cathelicidin (LL-37) may negatively impact the immune status of human immunodeficiency virus-1 (HIV-1) infected individuals (HIV+). Vitamin D 18-27 cathelicidin antimicrobial peptide Homo sapiens 74-79 24821067-2 2014 We compared plasma LL-37 levels in healthy controls (HIV-) and HIV+ individuals on or off antiretroviral therapies (ARTs) (ART+ and ART-, respectively), and evaluated the relationship between vitamin D and LL-37 levels. Vitamin D 192-201 cathelicidin antimicrobial peptide Homo sapiens 19-24 24039193-0 2014 Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids. Vitamin D 85-94 cathelicidin antimicrobial peptide Homo sapiens 31-65 22330698-7 2012 In multivariate regression models a significant positive correlation between serum vitamin D levels and the expression of vitamin D-regulated targets, cytochrome P450, family 24, subfamily a (cyp24a) expression by PBMCs (P = .0084, pediatric asthma group only) and serum LL-37 levels (P = .0006 in the pediatric group but P = .0067 in the adult asthma group), was found. Vitamin D 83-92 cathelicidin antimicrobial peptide Homo sapiens 271-276 25008764-1 2014 The recent discovery that vitamin D regulates expression of the cathelicidin antimicrobial peptide gene has generated renewed interest in using vitamin D to fight infectious diseases. Vitamin D 26-35 cathelicidin antimicrobial peptide Homo sapiens 64-98 25008764-1 2014 The recent discovery that vitamin D regulates expression of the cathelicidin antimicrobial peptide gene has generated renewed interest in using vitamin D to fight infectious diseases. Vitamin D 144-153 cathelicidin antimicrobial peptide Homo sapiens 64-98 24377473-2 2014 It has been shown that vitamin D is a major regulator of the expression of human antimicrobial peptide cathelicidin LL-37, which has a critical role in inflammatory cascade in psoriasis. Vitamin D 23-32 cathelicidin antimicrobial peptide Homo sapiens 116-121 23095332-1 2012 BACKGROUND: Transcription of the cathelicidin antimicrobial peptide (CAMP) gene is induced by binding of the bioactive form of vitamin D, 1,25-dihydroxyvitamin D, to the vitamin D receptor. Vitamin D 127-136 cathelicidin antimicrobial peptide Homo sapiens 33-67 23095332-1 2012 BACKGROUND: Transcription of the cathelicidin antimicrobial peptide (CAMP) gene is induced by binding of the bioactive form of vitamin D, 1,25-dihydroxyvitamin D, to the vitamin D receptor. Vitamin D 127-136 cathelicidin antimicrobial peptide Homo sapiens 69-73 23095332-3 2012 We hypothesized that serum vitamin D levels may modulate the circulating levels of hCAP18. Vitamin D 27-36 cathelicidin antimicrobial peptide Homo sapiens 83-89 23095332-8 2012 CONCLUSIONS: We conclude that plasma hCAP18 levels correlate with serum 25(OH)D levels in subjects with concentrations of 25(OH)D <= 32 ng/ml as opposed to those with concentrations > 32 ng/ml and that vitamin D status may regulate systemic levels of hCAP18/LL-37. Vitamin D 208-217 cathelicidin antimicrobial peptide Homo sapiens 37-43 22695798-9 2012 Gene and protein expression of hCAP-18 (p < 0.05) showed an increase in sebocytes treated with vitamin D. Vitamin D 98-107 cathelicidin antimicrobial peptide Homo sapiens 31-38 22695798-10 2012 Gene expression of hCAP-18 by treatment with vitamin D was blocked in sebocytes treated with VDR siRNA. Vitamin D 45-54 cathelicidin antimicrobial peptide Homo sapiens 19-26 22695798-11 2012 In conclusion, treatment with vitamin D resulted in increased expression of LL-37 through the vitamin D receptor of cultured sebocytes. Vitamin D 30-39 cathelicidin antimicrobial peptide Homo sapiens 76-81 22701042-6 2012 The discovery of LL-37-inducing components, such as butyrate and vitamin D(3), has opened new avenues to prevent or treat infections. Vitamin D 65-74 cathelicidin antimicrobial peptide Homo sapiens 17-22 22701042-7 2012 Butyrate and vitamin D(3) are potent inducers of LL-37 but in addition, have many other effects on host immunity. Vitamin D 13-22 cathelicidin antimicrobial peptide Homo sapiens 49-54 23330289-1 2012 UNLABELLED: The serum level of the human cathelicidin-LL37, an immunomodulatory vitamin D-induced peptide was less studied in viral hepatitis. Vitamin D 80-89 cathelicidin antimicrobial peptide Homo sapiens 54-58 23330289-9 2012 The Pearson correlation between the vitamin D status and LL37 level was weak. Vitamin D 36-45 cathelicidin antimicrobial peptide Homo sapiens 57-61 23045480-0 2012 Interleukin 13 exposure enhances vitamin D-mediated expression of the human cathelicidin antimicrobial peptide 18/LL-37 in bronchial epithelial cells. Vitamin D 33-42 cathelicidin antimicrobial peptide Homo sapiens 114-119 23045480-2 2012 Regulating expression of antimicrobial peptides, such as the human cathelicidin antimicrobial peptide 18 (hCAP18)/LL-37, by vitamin D in bronchial epithelial cells requires local conversion of 25(OH)-vitamin D(3) (25D(3)) into its bioactive metabolite, 1,25(OH)(2)-vitamin D(3) (1,25D(3)), by CYP27B1. Vitamin D 124-133 cathelicidin antimicrobial peptide Homo sapiens 106-112 23045480-2 2012 Regulating expression of antimicrobial peptides, such as the human cathelicidin antimicrobial peptide 18 (hCAP18)/LL-37, by vitamin D in bronchial epithelial cells requires local conversion of 25(OH)-vitamin D(3) (25D(3)) into its bioactive metabolite, 1,25(OH)(2)-vitamin D(3) (1,25D(3)), by CYP27B1. Vitamin D 124-133 cathelicidin antimicrobial peptide Homo sapiens 114-119 23045480-10 2012 In conclusion, we demonstrate that IL-13 induces vitamin D-dependent hCAP18/LL-37 expression, most likely by increasing CYP27B1. Vitamin D 49-58 cathelicidin antimicrobial peptide Homo sapiens 69-75 23045480-10 2012 In conclusion, we demonstrate that IL-13 induces vitamin D-dependent hCAP18/LL-37 expression, most likely by increasing CYP27B1. Vitamin D 49-58 cathelicidin antimicrobial peptide Homo sapiens 76-81 22330698-7 2012 In multivariate regression models a significant positive correlation between serum vitamin D levels and the expression of vitamin D-regulated targets, cytochrome P450, family 24, subfamily a (cyp24a) expression by PBMCs (P = .0084, pediatric asthma group only) and serum LL-37 levels (P = .0006 in the pediatric group but P = .0067 in the adult asthma group), was found. Vitamin D 122-131 cathelicidin antimicrobial peptide Homo sapiens 271-276 22292037-6 2012 The iSS model was optimized to 25OHD/1,25(OH)(2)D-mediated in vitro dose-responsive induction of the vitamin D target gene cathelicidin (CAMP) in human monocytes. Vitamin D 101-110 cathelicidin antimicrobial peptide Homo sapiens 137-141 22393183-9 2012 Improved vitamin D status can result in enhanced macrophage synthesis of 1,25-dihydroxyvitamin D, which increases the synthesis of the antimicrobial peptide cathelicidin (LL-37). Vitamin D 9-18 cathelicidin antimicrobial peptide Homo sapiens 171-176 22292037-10 2012 Finally, the iSS model was used to compare the efficiency of endogenously synthesized versus exogenously added 1,25(OH)(2)D. Data strongly support the endogenous model as the most viable mode for CAMP induction by vitamin D in vivo. Vitamin D 214-223 cathelicidin antimicrobial peptide Homo sapiens 196-200 21422187-2 2011 In myeloid and airway epithelial cells, the active form of vitamin D(3) [1,25(OH)(2)D(3)] increases the expression and antibacterial activity of LL-37. Vitamin D 59-68 cathelicidin antimicrobial peptide Homo sapiens 145-150 19878298-0 2010 Topical treatment with the vitamin D analogue calcipotriol enhances the upregulation of the antimicrobial protein hCAP18/LL-37 during wounding in human skin in vivo. Vitamin D 27-36 cathelicidin antimicrobial peptide Homo sapiens 114-120 21242105-6 2011 Though vitamin D"s anti-viral mechanism has not been fully established, it may be linked to vitamin D"s ability to up-regulate the anti-microbial peptides LL-37 and human beta defensin 2. Vitamin D 7-16 cathelicidin antimicrobial peptide Homo sapiens 155-160 21242105-6 2011 Though vitamin D"s anti-viral mechanism has not been fully established, it may be linked to vitamin D"s ability to up-regulate the anti-microbial peptides LL-37 and human beta defensin 2. Vitamin D 92-101 cathelicidin antimicrobial peptide Homo sapiens 155-160 20610636-3 2010 Laboratory studies provided a mechanism for this link on the basis of findings that vitamin D metabolites regulate the expression of cathelicidin (LL-37), which is an endogenous antimicrobial peptide with activity against Mycobacterium tuberculosis. Vitamin D 84-93 cathelicidin antimicrobial peptide Homo sapiens 147-152 20302931-0 2010 Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: past, present and future. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 27-61 20302931-8 2010 This review covers what we have learned in the past few years about the expression and function of CAMP under physiological and pathophysiological conditions, and addresses the potential future applications of vitamin D analogues to therapeutic regulation of CAMP expression. Vitamin D 210-219 cathelicidin antimicrobial peptide Homo sapiens 259-263 20890434-4 2010 Human beta defensin 2 (HBD2) and cathelicidin (LL-37) expressions in the PP skin were higher in serum vitamin D sufficient (VDS) groups than serum vitamin D deficient (VDD) groups. Vitamin D 102-111 cathelicidin antimicrobial peptide Homo sapiens 47-52 20890434-4 2010 Human beta defensin 2 (HBD2) and cathelicidin (LL-37) expressions in the PP skin were higher in serum vitamin D sufficient (VDS) groups than serum vitamin D deficient (VDD) groups. Vitamin D 147-156 cathelicidin antimicrobial peptide Homo sapiens 47-52 19645825-8 2010 Notably, the mechanism to upregulate hCAP18 following vitamin D treatment was functional in lesional as well as in non-lesional AD indicating that the CAMP gene is normally regulated in this respect. Vitamin D 54-63 cathelicidin antimicrobial peptide Homo sapiens 37-43 19645825-8 2010 Notably, the mechanism to upregulate hCAP18 following vitamin D treatment was functional in lesional as well as in non-lesional AD indicating that the CAMP gene is normally regulated in this respect. Vitamin D 54-63 cathelicidin antimicrobial peptide Homo sapiens 151-155 19645825-9 2010 In addition, cultured primary keratinocytes from non-lesional skin of psoriasis, AD and healthy skin, upregulated hCAP18mRNA following treatment with vitamin D. Vitamin D 150-159 cathelicidin antimicrobial peptide Homo sapiens 114-120 19878298-0 2010 Topical treatment with the vitamin D analogue calcipotriol enhances the upregulation of the antimicrobial protein hCAP18/LL-37 during wounding in human skin in vivo. Vitamin D 27-36 cathelicidin antimicrobial peptide Homo sapiens 121-126 19878298-7 2010 Vitamin D(3) and its analogue calcipotriol were recently found to directly induce transcription of the hCAP18 gene via functional vitamin D responsive elements in the hCAP18 gene promoter. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 103-109 19878298-7 2010 Vitamin D(3) and its analogue calcipotriol were recently found to directly induce transcription of the hCAP18 gene via functional vitamin D responsive elements in the hCAP18 gene promoter. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 167-173 19878298-7 2010 Vitamin D(3) and its analogue calcipotriol were recently found to directly induce transcription of the hCAP18 gene via functional vitamin D responsive elements in the hCAP18 gene promoter. Vitamin D 130-139 cathelicidin antimicrobial peptide Homo sapiens 103-109 19878298-7 2010 Vitamin D(3) and its analogue calcipotriol were recently found to directly induce transcription of the hCAP18 gene via functional vitamin D responsive elements in the hCAP18 gene promoter. Vitamin D 130-139 cathelicidin antimicrobial peptide Homo sapiens 167-173 19878298-10 2010 In the present study, we demonstrate that the upregulation of hCAP18/LL-37 following acute skin injury is further enhanced, at both hCAP18 mRNA and protein levels, after topical treatment with the vitamin D(3) analogue calcipotriol. Vitamin D 197-206 cathelicidin antimicrobial peptide Homo sapiens 62-68 19878298-10 2010 In the present study, we demonstrate that the upregulation of hCAP18/LL-37 following acute skin injury is further enhanced, at both hCAP18 mRNA and protein levels, after topical treatment with the vitamin D(3) analogue calcipotriol. Vitamin D 197-206 cathelicidin antimicrobial peptide Homo sapiens 69-74 19878298-10 2010 In the present study, we demonstrate that the upregulation of hCAP18/LL-37 following acute skin injury is further enhanced, at both hCAP18 mRNA and protein levels, after topical treatment with the vitamin D(3) analogue calcipotriol. Vitamin D 197-206 cathelicidin antimicrobial peptide Homo sapiens 132-138 19299728-1 2009 The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)(2)D) enhances innate immunity by inducing the cathelicidin antimicrobial peptide (hCAP). Vitamin D 19-28 cathelicidin antimicrobial peptide Homo sapiens 110-144 20592793-6 2009 Vitamin D upregulates production of human cathelicidin, LL-37, which has both antimicrobial and antiendotoxin activities. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 56-61 20049649-5 2010 Cellular production of LL-37 is affected by multiple factors, including bacterial products, host cytokines, availability of oxygen, and sun exposure through the activation of CAP-18 gene expression by vitamin D(3). Vitamin D 201-210 cathelicidin antimicrobial peptide Homo sapiens 23-28 20049649-5 2010 Cellular production of LL-37 is affected by multiple factors, including bacterial products, host cytokines, availability of oxygen, and sun exposure through the activation of CAP-18 gene expression by vitamin D(3). Vitamin D 201-210 cathelicidin antimicrobial peptide Homo sapiens 175-181 19943126-8 2009 Oral intake of 1alpha hydroxy vitamin D(3) (1alpha(OH)D(3)) in rickets patients for 4 weeks significantly increased hCAP18 expression in neutrophils compared to age-matched healthy controls without 1alpha(OH)D(3), indicating the potential of vitamin D(3) as a regulator of the innate immune response of neonates. Vitamin D 30-39 cathelicidin antimicrobial peptide Homo sapiens 116-122 19607716-3 2009 An ancient primate-specific Alu short interspersed element (SINE) put the human CAMP gene under the regulation of the vitamin D pathway by providing a perfect vitamin D receptor binding element (VDRE) in its promoter. Vitamin D 118-127 cathelicidin antimicrobial peptide Homo sapiens 80-84 19607716-13 2009 Evolutionary selection to place the primate CAMP gene under regulation of the vitamin D pathway potentiates the innate immune response and may counter the anti-inflammatory properties of vitamin D. Vitamin D 78-87 cathelicidin antimicrobial peptide Homo sapiens 44-48 19607716-13 2009 Evolutionary selection to place the primate CAMP gene under regulation of the vitamin D pathway potentiates the innate immune response and may counter the anti-inflammatory properties of vitamin D. Vitamin D 187-196 cathelicidin antimicrobial peptide Homo sapiens 44-48 19389235-2 2009 Recent evidence suggests that vitamin D may enhance the innate immune response by induction of cathelicidin (LL-37), an endogenous antimicrobial peptide produced by macrophages and neutrophils. Vitamin D 30-39 cathelicidin antimicrobial peptide Homo sapiens 109-114 19389235-3 2009 Thus, the relationship between vitamin D status and LL-37 production may be of importance for host immunity, but little data is available on this subject, especially in the setting of human sepsis syndrome and other critical illness. Vitamin D 31-40 cathelicidin antimicrobial peptide Homo sapiens 52-57 19389235-10 2009 It also establishes a positive association between vitamin D status and plasma LL-37, which suggests that systemic LL-37 levels may be regulated by vitamin D status. Vitamin D 51-60 cathelicidin antimicrobial peptide Homo sapiens 79-84 19389235-10 2009 It also establishes a positive association between vitamin D status and plasma LL-37, which suggests that systemic LL-37 levels may be regulated by vitamin D status. Vitamin D 51-60 cathelicidin antimicrobial peptide Homo sapiens 115-120 19389235-10 2009 It also establishes a positive association between vitamin D status and plasma LL-37, which suggests that systemic LL-37 levels may be regulated by vitamin D status. Vitamin D 148-157 cathelicidin antimicrobial peptide Homo sapiens 79-84 19389235-10 2009 It also establishes a positive association between vitamin D status and plasma LL-37, which suggests that systemic LL-37 levels may be regulated by vitamin D status. Vitamin D 148-157 cathelicidin antimicrobial peptide Homo sapiens 115-120 19063829-2 2009 Emerging evidence indicates that vitamin D-mediated innate immunity, particularly through enhanced expression of the human cathelicidin antimicrobial peptide (hCAP-18), is important in host defenses against respiratory tract pathogens. Vitamin D 33-42 cathelicidin antimicrobial peptide Homo sapiens 123-157 19005165-1 2009 The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)(2)D), is a potent inducer of the antimicrobial protein cathelicidin, CAMP (LL37). Vitamin D 19-28 cathelicidin antimicrobial peptide Homo sapiens 133-137 19005165-5 2009 Also consistent with macrophages, induction of trophoblastic CAMP was enhanced via intracrine conversion of 25OHD to 1,25(OH)(2)D. However, in contrast to macrophages, induction of CAMP by vitamin D in trophoblasts was not enhanced by costimulation with Toll-like receptor ligands, such as lipopolysaccharide. Vitamin D 189-198 cathelicidin antimicrobial peptide Homo sapiens 61-65 19005165-5 2009 Also consistent with macrophages, induction of trophoblastic CAMP was enhanced via intracrine conversion of 25OHD to 1,25(OH)(2)D. However, in contrast to macrophages, induction of CAMP by vitamin D in trophoblasts was not enhanced by costimulation with Toll-like receptor ligands, such as lipopolysaccharide. Vitamin D 189-198 cathelicidin antimicrobial peptide Homo sapiens 181-185 19133797-1 2009 BACKGROUND: Human cathelicidin antimicrobial protein (hCAP18) is an antimicrobial and immunomodulatory peptide that has pleiotropic effects and is transcriptionally regulated by vitamin D. Vitamin D 178-187 cathelicidin antimicrobial peptide Homo sapiens 54-60 19133797-2 2009 Because the administration of vitamin D analogues has been linked to decreased mortality among patients with end-stage renal disease, we hypothesized that low hCAP18 levels would identify those who are at increased risk of death attributable to infection while undergoing hemodialysis. Vitamin D 30-39 cathelicidin antimicrobial peptide Homo sapiens 159-165 19133797-8 2009 CONCLUSIONS: In individuals initiating chronic hemodialysis, low baseline levels of hCAP18, a vitamin D-regulated antimicrobial protein, are independently associated with an increased risk of death attributable to infection. Vitamin D 94-103 cathelicidin antimicrobial peptide Homo sapiens 84-90 19063829-2 2009 Emerging evidence indicates that vitamin D-mediated innate immunity, particularly through enhanced expression of the human cathelicidin antimicrobial peptide (hCAP-18), is important in host defenses against respiratory tract pathogens. Vitamin D 33-42 cathelicidin antimicrobial peptide Homo sapiens 159-166 15985530-5 2005 The induction occurred via a consensus vitamin D response element (VDRE) in the CAMP promoter that was bound by the vitamin D receptor (VDR). Vitamin D 39-48 cathelicidin antimicrobial peptide Homo sapiens 80-84 15322146-4 2004 The promoters of the human cathelicidin antimicrobial peptide (camp) and defensin beta2 (defB2) genes contain consensus vitamin D response elements that mediate 1,25(OH)(2)D(3)-dependent gene expression. Vitamin D 120-129 cathelicidin antimicrobial peptide Homo sapiens 27-61 15854055-0 2005 Vitamin D induces the antimicrobial protein hCAP18 in human skin. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 44-50 34401915-7 2022 Vitamin D correlation with LL-37 in healthy contacts was R2=0.7 (95% CI 0.566 to 0.944), p<0.0001. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 27-32 34836309-0 2021 Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1. Vitamin D 20-29 cathelicidin antimicrobial peptide Homo sapiens 167-171 34836309-9 2021 The correlation analysis of specific serum biomarkers with 25OHD indicated that the vitamin D action in COVID-19 might involve regulation of INOS1, IL1B, IFNg, cathelicidin-LL37, and ICAM1. Vitamin D 84-93 cathelicidin antimicrobial peptide Homo sapiens 173-177 35512569-0 2022 Vitamin D-induced LL-37 modulates innate immune responses of human primary macrophages during DENV-2 infection. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 18-23 34333809-8 2022 As Vitamin D is known to upregulate the expression of LL-37, the vitamin is a candidate preventive molecule. Vitamin D 3-12 cathelicidin antimicrobial peptide Homo sapiens 54-59 34420582-7 2021 In addition, an antimicrobial peptide, LL-37, which is known to be partly regulated by vitamin D, was also reported to exhibit an anti-HCV effect by disrupting infectious viral particles directly. Vitamin D 87-96 cathelicidin antimicrobial peptide Homo sapiens 39-44 35512569-7 2022 Finally, we demonstrate that low endogenous levels and limited production of LL-37 in MDMs in response to DENV-2 infection can be increased by differentiating MDMs in the presence of Vitamin D (VitD3). Vitamin D 183-192 cathelicidin antimicrobial peptide Homo sapiens 77-82 35057465-5 2022 Transcription of the human AMP genes beta-defensin 2/defensin-beta4 (HBD2/DEFB4) and cathelicidin antimicrobial peptide (CAMP) is stimulated by the VDR bound to promoter-proximal vitamin D response elements. Vitamin D 179-188 cathelicidin antimicrobial peptide Homo sapiens 121-125 35462022-9 2022 Vitamin D supplementation is recommended from the onset as a transcription factor to improve VDR and CAMP gene expression in leprosy patients. Vitamin D 0-9 cathelicidin antimicrobial peptide Homo sapiens 101-105 35057465-5 2022 Transcription of the human AMP genes beta-defensin 2/defensin-beta4 (HBD2/DEFB4) and cathelicidin antimicrobial peptide (CAMP) is stimulated by the VDR bound to promoter-proximal vitamin D response elements. Vitamin D 179-188 cathelicidin antimicrobial peptide Homo sapiens 85-119 35634307-6 2022 The bioactive form of vitamin D and a number of other compounds induce LL-37 expression and one might predict its upregulation, could reduce the prevalence of severe COVID-19. Vitamin D 22-31 cathelicidin antimicrobial peptide Homo sapiens 71-76 35444957-3 2022 This study examines the role of vitamin D deficiency in the regulation of Cathelicidin Antimicrobial Peptide (CAMP) in CD-like macrophages. Vitamin D 32-41 cathelicidin antimicrobial peptide Homo sapiens 110-114 35444957-14 2022 Altogether, the data indicate that MAP infection and burden is significant in CD by disrupting the conversion of calcifediol to calcitriol and downregulation of CAMP expression leading to vitamin D deficiency. Vitamin D 188-197 cathelicidin antimicrobial peptide Homo sapiens 161-165 35204769-0 2022 High Vitamin D Concentrations Restore the Ability to Express LL37 by M. tuberculosis-Infected Human Macrophages. Vitamin D 5-14 cathelicidin antimicrobial peptide Homo sapiens 61-65 35204769-7 2022 The expression of LL37 and the nucleus translocation of VDR were evaluated as the readout of the response of vitamin D and determined if those processes are affected by glucose concentrations. Vitamin D 109-118 cathelicidin antimicrobial peptide Homo sapiens 18-22 35204769-9 2022 The vitamin D-dependent induction of LL37 and the expression of VDR and CYP27B1 genes were analyzed by qPCR, and VDR translocation was analyzed in nuclear protein extracts by ELISA. Vitamin D 4-13 cathelicidin antimicrobial peptide Homo sapiens 37-41 35204769-11 2022 After evaluating two concentrations of vitamin D, 1 nM or 1 muM, the high concentration (1 muM) was necessary to restore the induction of LL37 expression in M. tuberculosis-infected macrophages. Vitamin D 39-48 cathelicidin antimicrobial peptide Homo sapiens 138-142 35204769-12 2022 High concentrations of the inactive form of vitamin D restore the infected macrophages" ability to express LL37 regardless of the glucose concentration. Vitamin D 44-53 cathelicidin antimicrobial peptide Homo sapiens 107-111 34985728-3 2022 The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)D), has been shown to induce the CAMP gene expression through promoter activation. Vitamin D 19-28 cathelicidin antimicrobial peptide Homo sapiens 96-100